                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  COMBINATION THERAPY FOR THE TREATMENT OF CANCER

<130>  PAT057506-WO-PCT

<150>  US 62/448,460
<151>  2017-01-20

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  162
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IL-15 (with signal peptide)

<400>  1

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  2
<211>  489
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Human IL-15 DNA (with signal peptide)

<400>  2
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210>  3
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IL-15 with GMCSF signal peptide

<400>  3
atgtggctcc agagcctgct actcctgggg acggtggcct gcagcatctc gaactgggtg       60

aacgtgatct cggacctgaa gaagatcgag gacctcatcc agtcgatgca catcgacgcg      120

acgctgtaca cggagtcgga cgtccacccg tcgtgcaagg tcacggcgat gaagtgcttc      180

ctcctggagc tccaagtcat ctcgctcgag tcgggggacg cgtcgatcca cgacacggtg      240

gagaacctga tcatcctggc gaacaactcg ctgtcgtcga acgggaacgt cacggagtcg      300

ggctgcaagg agtgcgagga gctggaggag aagaacatca aggagttcct gcagtcgttc      360

gtgcacatcg tccagatgtt catcaacacg tcgtga                                396


<210>  4
<211>  1847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-15 codon optimized DNA

<400>  4
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacaagaaat gcggatctcg      780

aagccgcacc tgcggtcgat atcgatccag tgctacctgt gcctgctcct gaactcgcac      840

ttcctcacgg aggccggtat acacgtcttc atcctgggct gcttctcggc ggggctgccg      900

aagacggagg cgaactgggt gaacgtgatc tcggacctga agaagatcga ggacctcatc      960

cagtcgatgc acatcgacgc gacgctgtac acggagtcgg acgtccaccc gtcgtgcaag     1020

gtcacggcga tgaagtgctt cctcctggag ctccaagtca tctcgctcga gtcgggggac     1080

gcgtcgatcc acgacacggt ggagaacctg atcatcctgg cgaacaactc gctgtcgtcg     1140

aacgggaacg tcacggagtc gggctgcaag gagtgcgagg agctggagga gaagaacatc     1200

aaggagttcc tgcagtcgtt cgtgcacatc gtccagatgt tcatcaacac gtcgtgaggg     1260

cccggcgcgc cgaattcgcg gatatcggtt aacggatcca gatctgctgt gccttctagt     1320

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     1380

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     1440

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     1500

aggcatgctg gggatgcggt gggctctatg ggtacccagg tgctgaagaa ttgacccggt     1560

tcctcctggg ccagaaagaa gcaggcacat ccccttctct gtgacacacc ctgtccacgc     1620

ccctggttct tagttccagc cccactcata ggacactcat agctcaggag ggctccgcct     1680

tcaatcccac ccgctaaagt acttggagcg gtctctccct ccctcatcag cccaccaaac     1740

caaacctagc ctccaagagt gggaagaaat taaagcaaga taggctatta agtgcagagg     1800

gagagaaaat gcctccaaca tgtgaggaag taatgagaga aatcata                   1847


<210>  5
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15 codon optimized amino acid

<400>  5

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  6
<211>  267
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IL-15Ra with signal peptide

<400>  6

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  7
<211>  200
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  Human soluble IL-15Ra with signal peptide

<400>  7

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly 
        195                 200 


<210>  8
<211>  804
<212>  DNA
<213>  Homo sapiens

<220>  
<223>  Human IL-15Ra with signal peptide DNA

<400>  8
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa      120

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      180

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      300

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      360

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      420

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      480

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      540

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc      600

cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct      660

gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa      720

atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg      780

gaaaactgct ctcaccacct atga                                             804


<210>  9
<211>  600
<212>  DNA
<213>  Homo sapiens

<220>  
<223>  Human soluble IL-15Ra with signal peptide DNA

<400>  9
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa      120

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      180

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      300

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      360

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      420

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      480

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      540

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc      600


<210>  10
<211>  170
<212>  PRT
<213>  Homo sapiens

<220>  
<223>  Human soluble IL-15Ra (PQG termination)

<400>  10

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
                165                 170 


<210>  11
<211>  2140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-15Ra codon optimized DNA

<400>  11
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacgctagca agaaatggcc      780

ccgaggcggg cgcgaggctg ccggaccctc ggtctcccgg cgctgctact gctcctgctg      840

ctccggccgc cggcgacgcg gggcatcacg tgcccgcccc ccatgtccgt ggagcacgca      900

gacatctggg tcaagagcta cagcttgtac tcccgggagc ggtacatctg caactcgggt      960

ttcaagcgga aggccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat     1020

gtcgcccact ggacgacccc ctcgctcaag tgcatccgcg acccggccct ggttcaccag     1080

cggcccgcgc caccctccac cgtaacgacg gcgggggtga ccccgcagcc ggagagcctc     1140

tccccgtcgg gaaaggagcc cgccgcgtcg tcgcccagct cgaacaacac ggcggccaca     1200

actgcagcga tcgtcccggg ctcccagctg atgccgtcga agtcgccgtc cacgggaacc     1260

acggagatca gcagtcatga gtcctcccac ggcaccccct cgcaaacgac ggccaagaac     1320

tgggaactca cggcgtccgc ctcccaccag ccgccggggg tgtatccgca aggccacagc     1380

gacaccacgg tggcgatctc cacgtccacg gtcctgctgt gtgggctgag cgcggtgtcg     1440

ctcctggcgt gctacctcaa gtcgaggcag actcccccgc tggccagcgt tgagatggag     1500

gccatggagg ctctgccggt gacgtggggg accagcagca gggatgagga cttggagaac     1560

tgctcgcacc acctataatg agaattcgat ccagatctgc tgtgccttct agttgccagc     1620

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg     1680

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc     1740

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg     1800

ctggggatgc ggtgggctct atgggtaccc aggtgctgaa gaattgaccc ggttcctcct     1860

gggccagaaa gaagcaggca catccccttc tctgtgacac accctgtcca cgcccctggt     1920

tcttagttcc agccccactc ataggacact catagctcag gagggctccg ccttcaatcc     1980

cacccgctaa agtacttgga gcggtctctc cctccctcat cagcccacca aaccaaacct     2040

agcctccaag agtgggaaga aattaaagca agataggcta ttaagtgcag agggagagaa     2100

aatgcctcca acatgtgagg aagtaatgag agaaatcata                           2140


<210>  12
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15Ra codon optimized amino acid

<400>  12

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  13
<211>  1971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV IL-15Ra codon optimized DNA

<400>  13
cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc       60

caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      120

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      180

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      240

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      300

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      360

atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      420

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca      480

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg      540

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact      600

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      660

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      720

gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacgctagca agaaatggcc      780

ccgaggcggg cgcgaggctg ccggaccctc ggtctcccgg cgctgctact gctcctgctg      840

ctccggccgc cggcgacgcg gggcatcacg tgcccgcccc ccatgtccgt ggagcacgca      900

gacatctggg tcaagagcta cagcttgtac tcccgggagc ggtacatctg caactcgggt      960

ttcaagcgga aggccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat     1020

gtcgcccact ggacgacccc ctcgctcaag tgcatccgcg acccggccct ggttcaccag     1080

cggcccgcgc caccctccac cgtaacgacg gcgggggtga ccccgcagcc ggagagcctc     1140

tccccgtcgg gaaaggagcc cgccgcgtcg tcgcccagct cgaacaacac ggcggccaca     1200

actgcagcga tcgtcccggg ctcccagctg atgccgtcga agtcgccgtc cacgggaacc     1260

acggagatca gcagtcatga gtcctcccac ggcaccccct cgcaaacgac ggccaagaac     1320

tgggaactca cggcgtccgc ctcccaccag ccgccggggg tgtatccgca aggccacagc     1380

gacaccacgt aatgagaatt cgcggatatc ggttaacgga tccagatctg ctgtgccttc     1440

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc     1500

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg     1560

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa     1620

tagcaggcat gctggggatg cggtgggctc tatgggtacc caggtgctga agaattgacc     1680

cggttcctcc tgggccagaa agaagcaggc acatcccctt ctctgtgaca caccctgtcc     1740

acgcccctgg ttcttagttc cagccccact cataggacac tcatagctca ggagggctcc     1800

gccttcaatc ccacccgcta aagtacttgg agcggtctct ccctccctca tcagcccacc     1860

aaaccaaacc tagcctccaa gagtgggaag aaattaaagc aagataggct attaagtgca     1920

gagggagaga aaatgcctcc aacatgtgag gaagtaatga gagaaatcat a              1971


<210>  14
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMV IL-15Ra codon optimized amino acid

<400>  14

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
        195                 200                 205 


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal of soluble human IL-15Ra

<400>  15

Pro Gln Gly His Ser Asp Thr Thr 
1               5               


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal of soluble human IL-15Ra

<400>  16

Pro Gln Gly His Ser Asp Thr 
1               5           


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal of soluble human IL-15Ra

<400>  17

Pro Gln Gly His Ser Asp 
1               5       


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal of soluble human IL-15Ra

<400>  18

Pro Gln Gly His Ser 
1               5   


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal of soluble human IL-15Ra

<400>  19

Pro Gln Gly His 
1               


<210>  20
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal of soluble human IL-15Ra

<400>  20

Pro Gln Gly 
1           


<210>  21
<211>  175
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human soluble IL-15Ra 

<400>  21

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15Ra O-glycosylation

<400>  22

Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr 
1               5                   10                  15      


Pro Gln Gly 
            


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15Ra N-glycosylation

<400>  23

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys 
    


<210>  24
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15Ra N-glycosylation

<400>  24

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            20                  25                  30      


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15Ra heterologous protease cleavage site recognized by furin 
       protease. Xaa = any amino acid


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Arg Xaa Xaa Arg 
1               


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15Ra heterologous protease cleavage site. 1,2 Xaa = 
       hydrophobic amino acids

5,6 Xaa = non-acidic amino acids


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Xaa Xaa Pro Arg Xaa Xaa 
1               5       


<210>  27
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sIL-15Ralpha-Fc fusion protein huIL15sRa205-Fc

<400>  27

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Lys Ser 
        195                 200                 205             


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    210                 215                 220                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
225                 230                 235                 240 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                245                 250                 255     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            260                 265                 270         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        275                 280                 285             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    290                 295                 300                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
305                 310                 315                 320 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                325                 330                 335     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            340                 345                 350         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        355                 360                 365             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    370                 375                 380                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
385                 390                 395                 400 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                405                 410                 415     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            420                 425                 430         


Ser Pro Gly Lys 
        435     


<210>  28
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sIL-15Ralpha-Fc fusion protein huIL15sRa200-Fc

<400>  28

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly Pro Lys Ser Cys Asp Lys Thr His 
        195                 200                 205             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    210                 215                 220                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
225                 230                 235                 240 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                245                 250                 255     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            260                 265                 270         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        275                 280                 285             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    290                 295                 300                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
305                 310                 315                 320 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                325                 330                 335     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            340                 345                 350         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        355                 360                 365             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    370                 375                 380                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
385                 390                 395                 400 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                405                 410                 415     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430     


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR1 (Kabat)

<400>  29

Thr Tyr Trp Met His 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR2 (Kabat)

<400>  30

Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR3 (Kabat)

<400>  31

Trp Thr Thr Gly Thr Gly Ala Tyr 
1               5               


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR1 (Chothia)

<400>  32

Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR2 (Chothia)

<400>  33

Tyr Pro Gly Thr Gly Gly 
1               5       


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR3 (Chothia)

<400>  34

Trp Thr Thr Gly Thr Gly Ala Tyr 
1               5               


<210>  35
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B VH

<400>  35

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Thr Thr Gly Thr Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B VH DNA

<400>  36
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaagc ccggcgagtc actgagaatt       60

agctgtaaag gttcaggcta caccttcact acctactgga tgcactgggt ccgccaggct      120

accggtcaag gcctcgagtg gatgggtaat atctaccccg gcaccggcgg ctctaacttc      180

gacgagaagt ttaagaatag agtgactatc accgccgata agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcac taggtggact      300

accggcacag gcgcctactg gggtcaaggc actaccgtga ccgtgtctag c               351


<210>  37
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HC

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Thr Thr Gly Thr Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  38
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HC DNA

<400>  38
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaagc ccggcgagtc actgagaatt       60

agctgtaaag gttcaggcta caccttcact acctactgga tgcactgggt ccgccaggct      120

accggtcaag gcctcgagtg gatgggtaat atctaccccg gcaccggcgg ctctaacttc      180

gacgagaagt ttaagaatag agtgactatc accgccgata agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcac taggtggact      300

accggcacag gcgcctactg gggtcaaggc actaccgtga ccgtgtctag cgctagcact      360

aagggcccgt ccgtgttccc cctggcacct tgtagccgga gcactagcga atccaccgct      420

gccctcggct gcctggtcaa ggattacttc ccggagcccg tgaccgtgtc ctggaacagc      480

ggagccctga cctccggagt gcacaccttc cccgctgtgc tgcagagctc cgggctgtac      540

tcgctgtcgt cggtggtcac ggtgccttca tctagcctgg gtaccaagac ctacacttgc      600

aacgtggacc acaagccttc caacactaag gtggacaagc gcgtcgaatc gaagtacggc      660

ccaccgtgcc cgccttgtcc cgcgccggag ttcctcggcg gtccctcggt ctttctgttc      720

ccaccgaagc ccaaggacac tttgatgatt tcccgcaccc ctgaagtgac atgcgtggtc      780

gtggacgtgt cacaggaaga tccggaggtg cagttcaatt ggtacgtgga tggcgtcgag      840

gtgcacaacg ccaaaaccaa gccgagggag gagcagttca actccactta ccgcgtcgtg      900

tccgtgctga cggtgctgca tcaggactgg ctgaacggga aggagtacaa gtgcaaagtg      960

tccaacaagg gacttcctag ctcaatcgaa aagaccatct cgaaagccaa gggacagccc     1020

cgggaacccc aagtgtatac cctgccaccg agccaggaag aaatgactaa gaaccaagtc     1080

tcattgactt gccttgtgaa gggcttctac ccatcggata tcgccgtgga atgggagtcc     1140

aacggccagc cggaaaacaa ctacaagacc acccctccgg tgctggactc agacggatcc     1200

ttcttcctct actcgcggct gaccgtggat aagagcagat ggcaggaggg aaatgtgttc     1260

agctgttctg tgatgcatga agccctgcac aaccactaca ctcagaagtc cctgtccctc     1320

tccctggga                                                             1329


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   BAP049-Clone-B LCDR1 (Kabat)

<400>  39

Lys Ser Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR2 (Kabat)

<400>  40

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR3 (Kabat)

<400>  41

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR1 (Chothia)

<400>  42

Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe 
1               5                   10              


<210>  43
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR2 (Chothia)

<400>  43

Trp Ala Ser 
1           


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR3 (Chothia)

<400>  44

Asp Tyr Ser Tyr Pro Tyr 
1               5       


<210>  45
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B VL

<400>  45

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  46
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B VL DNA

<400>  46
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg taaagcccct aagctgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tgcagcccga ggatatcgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaag                             339


<210>  47
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LC

<400>  47

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  48
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LC DNA

<400>  48
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg taaagcccct aagctgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tgcagcccga ggatatcgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaagc gtacggtggc cgctcccagc      360

gtgttcatct tcccccccag cgacgagcag ctgaagagcg gcaccgccag cgtggtgtgc      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caacgccctg      480

cagagcggca acagccagga gagcgtcacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcataaggt gtacgcctgc      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaacag gggcgagtgc      660


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR1 (Kabat)

<400>  49

Thr Tyr Trp Met His 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR2 (Kabat)

<400>  50

Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR3 (Kabat)

<400>  51

Trp Thr Thr Gly Thr Gly Ala Tyr 
1               5               


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR1 (Chothia)

<400>  52

Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR2 (Chothia)

<400>  53

Tyr Pro Gly Thr Gly Gly 
1               5       


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR3 (Chothia)

<400>  54

Trp Thr Thr Gly Thr Gly Ala Tyr 
1               5               


<210>  55
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E  VH

<400>  55

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Thr Thr Gly Thr Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  56
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E VH DNA

<400>  56
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaagc ccggcgagtc actgagaatt       60

agctgtaaag gttcaggcta caccttcact acctactgga tgcactgggt ccgccaggct      120

accggtcaag gcctcgagtg gatgggtaat atctaccccg gcaccggcgg ctctaacttc      180

gacgagaagt ttaagaatag agtgactatc accgccgata agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcac taggtggact      300

accggcacag gcgcctactg gggtcaaggc actaccgtga ccgtgtctag c               351


<210>  57
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HC

<400>  57

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Thr Gly Gly Ser Asn Phe Asp Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Thr Thr Gly Thr Gly Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  58
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HC DNA

<400>  58
gaggtgcagc tggtgcagtc aggcgccgaa gtgaagaagc ccggcgagtc actgagaatt       60

agctgtaaag gttcaggcta caccttcact acctactgga tgcactgggt ccgccaggct      120

accggtcaag gcctcgagtg gatgggtaat atctaccccg gcaccggcgg ctctaacttc      180

gacgagaagt ttaagaatag agtgactatc accgccgata agtctactag caccgcctat      240

atggaactgt ctagcctgag atcagaggac accgccgtct actactgcac taggtggact      300

accggcacag gcgcctactg gggtcaaggc actaccgtga ccgtgtctag cgctagcact      360

aagggcccgt ccgtgttccc cctggcacct tgtagccgga gcactagcga atccaccgct      420

gccctcggct gcctggtcaa ggattacttc ccggagcccg tgaccgtgtc ctggaacagc      480

ggagccctga cctccggagt gcacaccttc cccgctgtgc tgcagagctc cgggctgtac      540

tcgctgtcgt cggtggtcac ggtgccttca tctagcctgg gtaccaagac ctacacttgc      600

aacgtggacc acaagccttc caacactaag gtggacaagc gcgtcgaatc gaagtacggc      660

ccaccgtgcc cgccttgtcc cgcgccggag ttcctcggcg gtccctcggt ctttctgttc      720

ccaccgaagc ccaaggacac tttgatgatt tcccgcaccc ctgaagtgac atgcgtggtc      780

gtggacgtgt cacaggaaga tccggaggtg cagttcaatt ggtacgtgga tggcgtcgag      840

gtgcacaacg ccaaaaccaa gccgagggag gagcagttca actccactta ccgcgtcgtg      900

tccgtgctga cggtgctgca tcaggactgg ctgaacggga aggagtacaa gtgcaaagtg      960

tccaacaagg gacttcctag ctcaatcgaa aagaccatct cgaaagccaa gggacagccc     1020

cgggaacccc aagtgtatac cctgccaccg agccaggaag aaatgactaa gaaccaagtc     1080

tcattgactt gccttgtgaa gggcttctac ccatcggata tcgccgtgga atgggagtcc     1140

aacggccagc cggaaaacaa ctacaagacc acccctccgg tgctggactc agacggatcc     1200

ttcttcctct actcgcggct gaccgtggat aagagcagat ggcaggaggg aaatgtgttc     1260

agctgttctg tgatgcatga agccctgcac aaccactaca ctcagaagtc cctgtccctc     1320

tccctggga                                                             1329


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR1 (Kabat)

<400>  59

Lys Ser Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR2 (Kabat)

<400>  60

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR3 (Kabat)

<400>  61

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR1 (Chothia)

<400>  62

Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe 
1               5                   10              


<210>  63
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR2 (Chothia)

<400>  63

Trp Ala Ser 
1           


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR3 (Chothia)

<400>  64

Asp Tyr Ser Tyr Pro Tyr 
1               5       


<210>  65
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E VL

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  66
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   BAP049-Clone-E VL DNA

<400>  66
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg tcaagcccct agactgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tggaagccga ggacgccgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaag                             339


<210>  67
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LC

<400>  67

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  68
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LC DNA

<400>  68
gagatcgtcc tgactcagtc acccgctacc ctgagcctga gccctggcga gcgggctaca       60

ctgagctgta aatctagtca gtcactgctg gatagcggta atcagaagaa cttcctgacc      120

tggtatcagc agaagcccgg tcaagcccct agactgctga tctactgggc ctctactaga      180

gaatcaggcg tgccctctag gtttagcggt agcggtagtg gcaccgactt caccttcact      240

atctctagcc tggaagccga ggacgccgct acctactact gtcagaacga ctatagctac      300

ccctacacct tcggtcaagg cactaaggtc gagattaagc gtacggtggc cgctcccagc      360

gtgttcatct tcccccccag cgacgagcag ctgaagagcg gcaccgccag cgtggtgtgc      420

ctgctgaaca acttctaccc ccgggaggcc aaggtgcagt ggaaggtgga caacgccctg      480

cagagcggca acagccagga gagcgtcacc gagcaggaca gcaaggactc cacctacagc      540

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcataaggt gtacgcctgc      600

gaggtgaccc accagggcct gtccagcccc gtgaccaaga gcttcaacag gggcgagtgc      660


<210>  69
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR1 (Kabat)

<400>  69
acctactgga tgcac                                                        15


<210>  70
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR2 (Kabat)

<400>  70
aatatctacc ccggcaccgg cggctctaac ttcgacgaga agtttaagaa t                51


<210>  71
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR3 (Kabat)

<400>  71
tggactaccg gcacaggcgc ctac                                              24


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B  HCDR1 (Chothia)

<400>  72
ggctacacct tcactaccta c                                                 21


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR2 (Chothia)

<400>  73
taccccggca ccggcggc                                                     18


<210>  74
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HCDR3 (Chothia)

<400>  74
tggactaccg gcacaggcgc ctac                                              24


<210>  75
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR1 (Kabat)

<400>  75
aaatctagtc agtcactgct ggatagcggt aatcagaaga acttcctgac c                51


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR2 (Kabat)

<400>  76
tgggcctcta ctagagaatc a                                                 21


<210>  77
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR3 (Kabat)

<400>  77
cagaacgact atagctaccc ctacacc                                           27


<210>  78
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR1 (Chothia)

<400>  78
agtcagtcac tgctggatag cggtaatcag aagaacttc                              39


<210>  79
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR2 (Chothia)

<400>  79
tgggcctct                                                                9


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B LCDR3(Chothia)

<400>  80
gactatagct acccctac                                                     18


<210>  81
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR1 (Kabat)

<400>  81
acctactgga tgcac                                                        15


<210>  82
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR2 (Kabat)

<400>  82
aatatctacc ccggcaccgg cggctctaac ttcgacgaga agtttaagaa t                51


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR3 (Kabat)

<400>  83
tggactaccg gcacaggcgc ctac                                              24


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR1 (Chothia)

<400>  84
ggctacacct tcactaccta c                                                 21


<210>  85
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR2 (Chothia)

<400>  85
taccccggca ccggcggc                                                     18


<210>  86
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HCDR3 (Chothia)

<400>  86
tggactaccg gcacaggcgc ctac                                              24


<210>  87
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR1 (Kabat)

<400>  87
aaatctagtc agtcactgct ggatagcggt aatcagaaga acttcctgac c                51


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR2 (Kabat)

<400>  88
tgggcctcta ctagagaatc a                                                 21


<210>  89
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR3 (Kabat)

<400>  89
cagaacgact atagctaccc ctacacc                                           27


<210>  90
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR1 (Chothia)

<400>  90
agtcagtcac tgctggatag cggtaatcag aagaacttc                              39


<210>  91
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   BAP049-Clone-E LCDR2 (Chothia)

<400>  91
tgggcctct                                                                9


<210>  92
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LCDR3 (Chothia)

<400>  92
gactatagct acccctac                                                     18


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B/E HC

Combined HCDR1 Kabat/Chothia

<400>  93

Gly Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   10  


<210>  94
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-B HC leader sequence

<400>  94

Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Val Gln Ala 
            


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   BAP049-Clone-B LC Leader sequence

<400>  95

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  96
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E HC leader sequence

<400>  96

Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Val Gln Ala 
            


<210>  97
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP049-Clone-E LC leader sequence

<400>  97

Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  98
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 (S228P) mutant constant region amino acid sequence

<400>  98

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  99
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 (S228P) mutant constant region amino acid sequence lacing 
       C-terminal lysine (K)

<400>  99

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  100
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IgG1 wild type 

<400>  100

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  101
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 (N297A) mutant constant region amino acid sequence

<400>  101

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  102
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 (D265A, P329A) mutant constant region amino acid sequence

<400>  102

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  103
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 (L234A, L235A) mutant constant region amino acid sequence

<400>  103

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  104
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human kappa constant region amino acid sequence 

<400>  104

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


