                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> COMPOSITIONS AND METHODS FOR TREATING DISEASES CHARACTERIZED BY 
      REACTIVE MICROGLIA MEDIATED SYNAPSE LOSS

<130> 167705.010601/PCT

<140> PCT/US2018/014223
<141> 2018-01-18

<150> 62/448,840
<151> 2017-01-20

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Cys Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Ile Glu Gly Phe Asp Tyr Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 2
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Ala 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 3
<211> 189
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210> 4
<211> 863
<212> DNA
<213> Homo sapiens

<400> 4
caaggttcag agtcacccat ctcagcaagc ccagaagtat ctgcaatatc tacgatggcc       60

tcgccctttg ctttactgat ggtcctggtg gtgctcagct gcaagtcaag ctgctctctg      120

ggctgtgatc tccctgagac ccacagcctg gataacagga ggaccttgat gctcctggca      180

caaatgagca gaatctctcc ttcctcctgt ctgatggaca gacatgactt tggatttccc      240

caggaggagt ttgatggcaa ccagttccag aaggctccag ccatctctgt cctccatgag      300

ctgatccagc agatcttcaa cctctttacc acaaaagatt catctgctgc ttgggatgag      360

gacctcctag acaaattctg caccgaactc taccagcagc tgaatgactt ggaagcctgt      420

gtgatgcagg aggagagggt gggagaaact cccctgatga atgcggactc catcttggct      480

gtgaagaaat acttccgaag aatcactctc tatctgacag agaagaaata cagcccttgt      540

gcctgggagg ttgtcagagc agaaatcatg agatccctct ctttatcaac aaacttgcaa      600

gaaagattaa ggaggaagga ataacatctg gtccaacatg aaaacaattc ttattgactc      660

atacaccagg tcacgctttc atgaattctg tcatttcaaa gactctcacc cctgctataa      720

ctatgaccat gctgataaac tgatttatct atttaaatat ttatttaact attcataaga      780

tttaaattat ttttgttcat ataacgtcat gtgcaccttt acactgtggt tagtgtaata      840

aaacatgttc cttatattta ctc                                              863


<210> 5
<211> 187
<212> PRT
<213> Homo sapiens

<400> 5
Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Cys Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Arg Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Val Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Arg Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Arg Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Asp Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Val Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210> 6
<211> 859
<212> DNA
<213> Homo sapiens

<400> 6
ccatacccat ggagaaagga cattctaact gcaacctttc gaagcctttg ctctggcaca       60

acaggtagta ggcgacactg ttcgtgttgt caacatgacc aacaagtgtc tcctccaaat      120

tgctctcctg ttgtgcttct ccactacagc tctttccatg agctacaact tgcttggatt      180

cctacaaaga agcagcaatt ttcagtgtca gaagctcctg tggcaattga atgggaggct      240

tgaatactgc ctcaaggaca ggatgaactt tgacatccct gaggagatta agcagctgca      300

gcagttccag aaggaggacg ccgcattgac catctatgag atgctccaga acatctttgc      360

tattttcaga caagattcat ctagcactgg ctggaatgag actattgttg agaacctcct      420

ggctaatgtc tatcatcaga taaaccatct gaagacagtc ctggaagaaa aactggagaa      480

agaagatttc accaggggaa aactcatgag cagtctgcac ctgaaaagat attatgggag      540

gattctgcat tacctgaagg ccaaggagta cagtcactgt gcctggacca tagtcagagt      600

ggaaatccta aggaactttt acttcattaa cagacttaca ggttacctcc gaaactgaag      660

atctcctagc ctgtgcctct gggactggac aattgcttca agcattcttc aaccagcaga      720

tgctgtttaa gtgactgatg gctaatgtac tgcatatgaa aggacactag aagattttga      780

aatttttatt aaattatgag ttatttttat ttatttaaat tttattttgg aaaataaatt      840

atttttggtg caaaagtca                                                   859


<210> 7
<211> 847
<212> PRT
<213> Homo sapiens

<400> 7
Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210> 8
<211> 3300
<212> DNA
<213> Homo sapiens

<400> 8
acttctcctt ttgctctcag atgctgccag ggtccctgaa gagggaagac acgcggaaac       60

aggcttgcac ccagacacga caccatgcat ctcctcggcc cctggctcct gctcctggtt      120

ctagaatact tggctttctc tgactcaagt aaatgggttt ttgagcaccc tgaaaccctc      180

tacgcctggg agggggcctg cgtctggatc ccctgcacct acagagccct agatggtgac      240

ctggaaagct tcatcctgtt ccacaatcct gagtataaca agaacacctc gaagtttgat      300

gggacaagac tctatgaaag cacaaaggat gggaaggttc cttctgagca gaaaagggtg      360

caattcctgg gagacaagaa taagaactgc acactgagta tccacccggt gcacctcaat      420

gacagtggtc agctggggct gaggatggag tccaagactg agaaatggat ggaacgaata      480

cacctcaatg tctctgaaag gccttttcca cctcatatcc agctccctcc agaaattcaa      540

gagtcccagg aagtcactct gacctgcttg ctgaatttct cctgctatgg gtatccgatc      600

caattgcagt ggctcctaga gggggttcca atgaggcagg ctgctgtcac ctcgacctcc      660

ttgaccatca agtctgtctt cacccggagc gagctcaagt tctccccaca gtggagtcac      720

catgggaaga ttgtgacctg ccagcttcag gatgcagatg ggaagttcct ctccaatgac      780

acggtgcagc tgaacgtgaa gcacaccccg aagttggaga tcaaggtcac tcccagtgat      840

gccatagtga gggaggggga ctctgtgacc atgacctgcg aggtcagcag cagcaacccg      900

gagtacacga cggtatcctg gctcaaggat gggacctcgc tgaagaagca gaatacattc      960

acgctaaacc tgcgcgaagt gaccaaggac cagagtggga agtactgctg tcaggtctcc     1020

aatgacgtgg gcccgggaag gtcggaagaa gtgttcctgc aagtgcagta tgccccggaa     1080

ccttccacgg ttcagatcct ccactcaccg gctgtggagg gaagtcaagt cgagtttctt     1140

tgcatgtcac tggccaatcc tcttccaaca aattacacgt ggtaccacaa tgggaaagaa     1200

atgcagggaa ggacagagga gaaagtccac atcccaaaga tcctcccctg gcacgctggg     1260

acttattcct gtgtggcaga aaacattctt ggtactggac agaggggccc gggagctgag     1320

ctggatgtcc agtatcctcc caagaaggtg accacagtga ttcaaaaccc catgccgatt     1380

cgagaaggag acacagtgac cctttcctgt aactacaatt ccagtaaccc cagtgttacc     1440

cggtatgaat ggaaacccca tggcgcctgg gaggagccat cgcttggggt gctgaagatc     1500

caaaacgttg gctgggacaa cacaaccatc gcctgcgcag cttgtaatag ttggtgctcg     1560

tgggcctccc ctgtcgccct gaatgtccag tatgcccccc gagacgtgag ggtccggaaa     1620

atcaagcccc tttccgagat tcactctgga aactcggtca gcctccaatg tgacttctca     1680

agcagccacc ccaaagaagt ccagttcttc tgggagaaaa atggcaggct tctggggaaa     1740

gaaagccagc tgaattttga ctccatctcc ccagaagatg ctgggagtta cagctgctgg     1800

gtgaacaact ccataggaca gacagcgtcc aaggcctgga cacttgaagt gctgtatgca     1860

cccaggaggc tgcgtgtgtc catgagcccg ggggaccaag tgatggaggg gaagagtgca     1920

accctgacct gtgagagcga cgccaaccct cccgtctccc actacacctg gtttgactgg     1980

aataaccaaa gcctccccta ccacagccag aagctgagat tggagccggt gaaggtccag     2040

cactcgggtg cctactggtg ccaggggacc aacagtgtgg gcaagggccg ttcgcctctc     2100

agcaccctca ccgtctacta tagcccggag accatcggca ggcgagtggc tgtgggactc     2160

gggtcctgcc tcgccatcct catcctggca atctgtgggc tcaagctcca gcgacgttgg     2220

aagaggacac agagccagca ggggcttcag gagaattcca gcggccagag cttctttgtg     2280

aggaataaaa aggttagaag ggcccccctc tctgaaggcc cccactccct gggatgctac     2340

aatccaatga tggaagatgg cattagctac accaccctgc gctttcccga gatgaacata     2400

ccacgaactg gagatgcaga gtcctcagag atgcagagac ctcccccgga ctgcgatgac     2460

acggtcactt attcagcatt gcacaagcgc caagtgggcg actatgagaa cgtcattcca     2520

gattttccag aagatgaggg gattcattac tcagagctga tccagtttgg ggtcggggag     2580

cggcctcagg cacaagaaaa tgtggactat gtgatcctca aacattgaca ctggatgggc     2640

tgcagcagag gcactggggg cagcgggggc cagggaagtc cccgagtttc cccagacacc     2700

gccacatggc ttcctcctgc gcgcatgtgc gcacacacac acacacacgc acacacacac     2760

acacacactc actgcggaga accttgtgcc tggctcagag ccagtctttt tggtgagggt     2820

aaccccaaac ctccaaaact cctgcccctg ttctcttcca ctctccttgc tacccagaaa     2880

tccatctaaa tacctgccct gacatgcaca cctccccctg cccccaccac ggccactggc     2940

catctccacc cccagctgct tgtgtccctc ctgggatctg ctcgtcatca tttttccttc     3000

ccttctccat ctctctggcc ctctacccct gatctgacat ccccactcac gaatattatg     3060

cccagtttct gcctctgagg gaaagcccag aaaaggacag aaacgaagta gaaaggggcc     3120

cagtcctggc ctggcttctc ctttggaagt gaggcattgc acggggagac gtacgtatca     3180

gcggcccctt gactctgggg actccgggtt tgagatggac acactggtgt ggattaacct     3240

gccagggaga cagagctcac aataaaaatg gctcagatgc cacttcaaag aaaaaaaaaa     3300


<210> 9
<211> 557
<212> PRT
<213> Homo sapiens

<400> 9
Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
            260                 265                 270         


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
        275                 280                 285             


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
    290                 295                 300                 


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
                325                 330                 335     


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
            340                 345                 350         


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
        355                 360                 365             


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
    370                 375                 380                 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
385                 390                 395                 400 


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
                405                 410                 415     


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
            420                 425                 430         


Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe 
        435                 440                 445             


Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile 
    450                 455                 460                 


Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
465                 470                 475                 480 


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
                485                 490                 495     


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala 
            500                 505                 510         


Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser 
        515                 520                 525             


Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser 
    530                 535                 540                 


Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val 
545                 550                 555         


<210> 10
<211> 6100
<212> DNA
<213> Homo sapiens

<400> 10
aggcggcgcg tgcgtagagg ggcggtgaga gctaagaggg gcagcgcgtg tgcagagggg       60

cggtgtgact taggacgggg cgatggcggc tgagaggagc tgcgcgtgcg cgaacatgta      120

actggtggga tctgcggcgg ctcccagatg atggtcgtcc tcctgggcgc gacgacccta      180

gtgctcgtcg ccgtggcgcc atgggtgttg tccgcagccg caggtggaaa aaatctaaaa      240

tctcctcaaa aagtagaggt cgacatcata gatgacaact ttatcctgag gtggaacagg      300

agcgatgagt ctgtcgggaa tgtgactttt tcattcgatt atcaaaaaac tgggatggat      360

aattggataa aattgtctgg gtgtcagaat attactagta ccaaatgcaa cttttcttca      420

ctcaagctga atgtttatga agaaattaaa ttgcgtataa gagcagaaaa agaaaacact      480

tcttcatggt atgaggttga ctcatttaca ccatttcgca aagctcagat tggtcctcca      540

gaagtacatt tagaagctga agataaggca atagtgatac acatctctcc tggaacaaaa      600

gatagtgtta tgtgggcttt ggatggttta agctttacat atagcttagt tatctggaaa      660

aactcttcag gtgtagaaga aaggattgaa aatatttatt ccagacataa aatttataaa      720

ctctcaccag agactactta ttgtctaaaa gttaaagcag cactacttac gtcatggaaa      780

attggtgtct atagtccagt acattgtata aagaccacag ttgaaaatga actacctcca      840

ccagaaaata tagaagtcag tgtccaaaat cagaactatg ttcttaaatg ggattataca      900

tatgcaaaca tgacctttca agttcagtgg ctccacgcct ttttaaaaag gaatcctgga      960

aaccatttgt ataaatggaa acaaatacct gactgtgaaa atgtcaaaac tacccagtgt     1020

gtctttcctc aaaacgtttt ccaaaaagga atttaccttc tccgcgtaca agcatctgat     1080

ggaaataaca catctttttg gtctgaagag ataaagtttg atactgaaat acaagctttc     1140

ctacttcctc cagtctttaa cattagatcc cttagtgatt cattccatat ctatatcggt     1200

gctccaaaac agtctggaaa cacgcctgtg atccaggatt atccactgat ttatgaaatt     1260

attttttggg aaaacacttc aaatgctgag agaaaaatta tcgagaaaaa aactgatgtt     1320

acagttccta atttgaaacc actgactgta tattgtgtga aagccagagc acacaccatg     1380

gatgaaaagc tgaataaaag cagtgttttt agtgacgctg tatgtgagaa aacaaaacca     1440

ggaaatacct ctaaaatttg gcttatagtt ggaatttgta ttgcattatt tgctctcccg     1500

tttgtcattt atgctgcgaa agtcttcttg agatgcatca attatgtctt ctttccatca     1560

cttaaacctt cttccagtat agatgagtat ttctctgaac agccattgaa gaatcttctg     1620

ctttcaactt ctgaggaaca aatcgaaaaa tgtttcataa ttgaaaatat aagcacaatt     1680

gctacagtag aagaaactaa tcaaactgat gaagatcata aaaaatacag ttcccaaact     1740

agccaagatt caggaaatta ttctaatgaa gatgaaagcg aaagtaaaac aagtgaagaa     1800

ctacagcagg actttgtatg accagaaatg aactgtgtca agtataaggt ttttcagcag     1860

gagttacact gggagcctga ggtcctcacc ttcctctcag taactacaga gaggacgttt     1920

ccctgtttag ggaaagaaaa aacatcttca gatcataggt cctaaaaata cgggcaagct     1980

cttaactatt taaaaatgaa attacaggcc cgggcacggt ggctcacacc tgtaatccca     2040

gcactttggg aggctgaggc aggcagatca tgaggtcaag agatcgagac cagcctggcc     2100

aacgtggtga aaccccatct ctactaaaaa tacaaaaatt agccgggtgt ggtggcgcgc     2160

gcctgttgtc ttagctactc aggaggctga ggcaggagaa tcgcttgaaa acaggaggtg     2220

gaggttgcag tgagccgaga tcacgccact gcactccagc ctggtgacag cgtgagactc     2280

tttaaaaaaa gaaattaaaa gagttgagac aaacgtttcc tacattcttt tccatgtgta     2340

aaatcatgaa aaagcctgtc accggacttg cattggatga gatgagtcag accaaaacag     2400

tggccacccg tcttcctcct gtgagcctaa gtgcagccgt gctagctgcg caccgtggct     2460

aaggatgacg tctgtgttcc tgtccatcac tgatgctgct ggctactgca tgtgccacac     2520

ctgtctgttc gccattccta acattctgtt tcattcttcc tcgggagata tttcaaacat     2580

ttggtctttt cttttaacac tgagggtagg cccttaggaa atttatttag gaaagtctga     2640

acacgttatc acttggtttt ctggaaagta gcttacccta gaaaacagct gcaaatgcca     2700

gaaagatgat ccctaaaaat gttgagggac ttctgttcat tcatcccgag aacattggct     2760

tccacatcac agtatctacc cttacatggt ttaggattaa agccaggcaa tcttttacta     2820

tgcattaaga cctctgattc aaaacttatt agaacagtag cttctgctgg aatttgcaat     2880

cactgaagtc atagaaaata ggtaactatc taattagaga aataattgtt gtattttaag     2940

atctgagagt gtgtacaagt tttagtatac atgccatgcc agaagatagt gtatgcaaga     3000

agtcttggga ccagaaaatg gcaatgatag gagactgaca tagaagaaga atgcttccct     3060

aggaaaaagg tcgctggctt tggtgcaaga ggaagaagaa tgttccactg gaagcctgag     3120

cacctaatca gctctcagtg atcaacccac tcttgttatg ggtggtctct gtcactttga     3180

atgccaggct ggcttctcgt ctagcagtat tcagataccc cttctgctca gcctgcttgg     3240

cgttaaaata caaatcattg aactgagggg gaaaaatgta actaggaaga aaaacccaat     3300

ttaagaaatt acataatgct ttccaaaggc acctacaact tagttttaaa ttacttgcta     3360

ctggggatta cccatggata tccttaatag gcaggaagtc tgggaattct ggtggcctct     3420

agggcagtgt tctcacagca ccgttccgac agggaccagt gaaagaaaag agacaaagtt     3480

agaacgtgct ggggagcggc catttctaag gccagtctgg tttaagtagt catttctgct     3540

gaaaaaacag atgatcctgg tggaagaaaa ggttgaaggc agctgccctc gggagggctg     3600

tgatgctcgg cacatcctgc ctggcacata cacgtgtctg caggccacac cgtgcatgtc     3660

cccagacctg ccgcctggct tctggagtgc ttcaagcaga gcatggtggg tcattgagga     3720

gacccaggaa tctcatctga gaacccactc tctgccggag aaccccatgg tgacacattt     3780

tcatctttct gaccagaggc tgtttttttt tttttttgag acagtctcat tctgttgccc     3840

aggctggagt gcagtggctt gatctcggct cactgcaacc tcgcctcccg ggttcaagca     3900

attctctgcc gcagcctcca gagtagctgg gataacaggt gcccaccacc acaccccact     3960

aatttttgta tttgtatttt tagtagagat ggggtttcac catgttggtc aggctggtct     4020

tggactcctg acctcatgct ccacccgctt cggcctccca aagttctggg attacaggtg     4080

tgagccaccg tgcacggccg gcctgacctt tggaaaagcc ttgtcacttt ggacgtttgc     4140

gtctttgaag aggcgatggg agcatatcat gactgcctgc caccattgct tttcagacta     4200

ccacaactca atcatgctgt ccaggacttc tggccctgtg ttcaccactg ggaaaacgta     4260

cttcagactg gatagcctaa aaaggagcaa tgcccttgta ggatgtggag aagggaaaat     4320

acggacatta acattaaaag acaccagtga aattgttagg tctctaggaa gttggagcac     4380

aaggcttcac gctttaagac catctgtggt tttcagtgaa caagcgctga gcaccagcag     4440

cagaaaacaa caacaaaaaa acacctcgtt tttaccttgt cttctagaca tgaaaaggca     4500

gttgcattcc actctgcatt atgttctaca tgttgcttta tcagtatatg cttagctgta     4560

agtgacaagt attttttctg aacagaagtt tacttagaaa taccatgcac ttgggggtac     4620

caattaaccg cctgaaaatt agcatattga tagttcttag agagaccaga tataatctaa     4680

gaatttatat gaaagatttg tatcattaga gccagaaata attttatatt aatatataat     4740

acagattaac attatatata atatgtacct gtgtcacttc tgacatgagc ctgtaaacat     4800

atattcatat atgtacctgc acatgtaccc acctgatgta ggtcttattc ctttagtatg     4860

gacttaaagt acttattcat ataccttgta actaaaaatt agaacagctc cctagaattg     4920

tgaactttta agagtctgac tagaaatttg caacttataa aaaagttact tttaaaaata     4980

taagttaggg ctaggcacag tggctcatgc ctataatctc agcacttttg ggaggccaag     5040

acaggaggat cacttcaggc caggagttca agatcaacca acctgggtaa catggccaga     5100

ccccatctct atttatatat atatatataa aacttagagt ttttatcttc ccctaaaaga     5160

ggccgtgata tttgcagcag cctcaaattg ctcttaaggg gtttaggtgt gcagaagctt     5220

tcctttccct acccagtaac catgtgacta ctaacgtggt atattgattt attttgtttg     5280

ctgtctgtct cccctgcccc actgctggaa cagaggctcc aagaaaacag ggaccttatt     5340

attcattact gcatccccag taatgaaagt acttagaaaa taattattga atgaatgaaa     5400

tctaaactgt gaacctgagg gtgtttgtgg cagtgtttgt tttactgaat tgtagaagga     5460

cataaccgtg ttttcagtgt ttctatggaa caaacttgta cattttattt cacttgtgtt     5520

ttgtcttaaa ccctactgct ggaaacaatt ttatgtaata agcaatgggc ccaaaagtct     5580

aggagttttt ttgtacttag tgaatttgta tgcaacagag atgctgcagc tgatgccttt     5640

aaaaggtatt catcatggaa gagctgaggc ctgtgcttgg tgttccagag cccagggttg     5700

agcatcctga aggagccact gcagccgtca ctgtccccag agcctgtgga gatagagcct     5760

gtttgctgct ttttcttccc gctcttaaga catggctgga gctcagtctt cattgaatga     5820

agtttgctgt ggtattgcat agccttgctt tcttgaacta aactgtttgc ccttcacaag     5880

tagttcttct ttcaggatta gttcgttcca aggaggctct tcagtctcac agataagtag     5940

atctctcctg ctgtctggac acatttcact cggaaattga atacaatttg tattcaggct     6000

gggaacctga acacacactt gtgtttttaa gcttcccttt tttacagtgg acaaggacac     6060

aaataataaa taaatcatcc ctaatgccca aagaaaaaaa                           6100


