                         SEQUENCE LISTING

<110>  Ƽ޹˾
 
<120>  ￹MSLNǶϿԭ޹EGFRתܰϸ;

<130>  PIDC1160952P

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  507
<212>  PRT
<213>  Artificial

<220>
<223>  ǶϿԭİ

<400>  1

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Ala Gln Val Gln Leu Val Gln 
            20                  25                  30          


Ser Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys 
        35                  40                  45              


Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser 
65                  70                  75                  80  


Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr 
                85                  90                  95      


Asn Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr 
            100                 105                 110         


Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly 
        115                 120                 125             


Asp Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ser Phe Val 
            260                 265                 270         


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            340                 345                 350         


Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        355                 360                 365             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    370                 375                 380                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
385                 390                 395                 400 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                405                 410                 415     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            420                 425                 430         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        435                 440                 445             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    450                 455                 460                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
465                 470                 475                 480 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                485                 490                 495     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505         


<210>  2
<211>  1524
<212>  DNA
<213>  Artificial

<220>
<223>  ǶϿԭĺĺ

<400>  2
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc ttcgtgccgg tcttcctgcc agcgaagccc    840

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg    900

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    960

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc   1020

ctgtcactgg ttatcaccct ttactgcaac cacaggaaca aacggggcag aaagaaactc   1080

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc   1140

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc   1200

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat   1260

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg   1320

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat   1380

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg   1440

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac   1500

atgcaggccc tgccccctcg ctaa                                          1524


<210>  3
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  ޹EGFRİ

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Arg Lys Val Cys Asn Gly Ile Gly Ile 
            20                  25                  30          


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
        35                  40                  45              


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
    50                  55                  60                  


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
65                  70                  75                  80  


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
                85                  90                  95      


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
            100                 105                 110         


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
        115                 120                 125             


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
    130                 135                 140                 


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
145                 150                 155                 160 


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
                165                 170                 175     


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
            180                 185                 190         


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
        195                 200                 205             


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
    210                 215                 220                 


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
225                 230                 235                 240 


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
                245                 250                 255     


Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys 
            260                 265                 270         


Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly 
        275                 280                 285             


Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly 
    290                 295                 300                 


His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly 
305                 310                 315                 320 


Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
                325                 330                 335     


Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu 
            340                 345                 350         


Gly Ile Gly Leu Phe Met Arg Arg 
        355                 360 


<210>  4
<211>  1083
<212>  DNA
<213>  Artificial

<220>
<223>  ޹EGFRĺӵĺ

<400>  4
atggctctgc ccgtcaccgc tctgctgctg cctctggctc tgctgctgca cgccgcacgc     60

cctgggagtc gcaaagtctg taatgggatc ggcatcggcg agttcaagga cagcctgtcc    120

atcaacgcca ccaatatcaa gcactttaag aattgcacat ctatcagcgg cgacctgcac    180

atcctgccag tggccttccg gggcgattct tttacccaca caccccctct ggaccctcag    240

gagctggata tcctgaagac cgtgaaggag atcacaggct tcctgctgat ccaggcctgg    300

cctgagaaca gaaccgatct gcacgccttt gagaatctgg agatcatccg gggcagaaca    360

aagcagcacg gccagttctc cctggccgtg gtgtctctga acatcaccag cctgggcctg    420

aggtccctga aggagatctc tgacggcgat gtgatcatct ccggcaacaa gaacctgtgc    480

tacgccaaca caatcaattg gaagaagctg tttggcacct ctggccagaa gacaaagatc    540

atctctaacc ggggcgagaa tagctgcaag gcaaccggac aggtgtgcca cgcactgtgc    600

agcccagagg gatgttgggg cccagagcca cgggactgcg tgagctgtag aaacgtgtcc    660

aggggccgcg agtgcgtgga taagtgtaat ctgctggagg gcgagccaag ggagttcgtg    720

gagaactccg agtgcatcca gtgtcacccc gagtgcctgc ctcaggccat gaacatcacc    780

tgtacaggcc gcggccccga caattgcatc cagtgtgccc actatatcga tggccctcac    840

tgcgtgaaga cctgtccagc cggcgtgatg ggcgagaaca atacactggt gtggaagtac    900

gcagacgcag gacacgtgtg ccacctgtgc caccccaatt gcacctatgg ctgtacagga    960

ccaggcctgg agggatgccc aaccaacggc cctaagatcc caagcatcgc cacaggcatg   1020

gtgggggcac tgctgctgct gctggtggtg gctctgggga ttgggctgtt tatgagaagg   1080

taa                                                                 1083


<210>  5
<211>  3223
<212>  DNA
<213>  Artificial

<220>
<223>  MSLN CAR/tEGFRĺ

<400>  5
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc accactaccc cagcaccgag gccacccacc    840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca    900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc    960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag   1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact   1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa   1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct accagcaggg gcagaaccag   1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga   1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac   1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa   1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac   1440

acctatgacg ctcttcacat gcaggccctg ccgcctcggt aatcctactg cgtcgacact   1500

agtgaattcg aatttaaatc ggatccgcgg ccgcgcccct ctccctcccc cccccctaac   1560

gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc   1620

accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg   1680

agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg   1740

aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc   1800

aggcagcgga accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa   1860

gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa   1920

agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta   1980

ccccattgta tgggatctga tctggggcct cggtgcacat gctttacatg tgtttagtcg   2040

aggttaaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca   2100

cgatgataat atggccacaa ccatggcgtc cggatctaga atggctctgc ccgtcaccgc   2160

tctgctgctg cctctggctc tgctgctgca cgccgcacgc cctgggagtc gcaaagtctg   2220

taatgggatc ggcatcggcg agttcaagga cagcctgtcc atcaacgcca ccaatatcaa   2280

gcactttaag aattgcacat ctatcagcgg cgacctgcac atcctgccag tggccttccg   2340

gggcgattct tttacccaca caccccctct ggaccctcag gagctggata tcctgaagac   2400

cgtgaaggag atcacaggct tcctgctgat ccaggcctgg cctgagaaca gaaccgatct   2460

gcacgccttt gagaatctgg agatcatccg gggcagaaca aagcagcacg gccagttctc   2520

cctggccgtg gtgtctctga acatcaccag cctgggcctg aggtccctga aggagatctc   2580

tgacggcgat gtgatcatct ccggcaacaa gaacctgtgc tacgccaaca caatcaattg   2640

gaagaagctg tttggcacct ctggccagaa gacaaagatc atctctaacc ggggcgagaa   2700

tagctgcaag gcaaccggac aggtgtgcca cgcactgtgc agcccagagg gatgttgggg   2760

cccagagcca cgggactgcg tgagctgtag aaacgtgtcc aggggccgcg agtgcgtgga   2820

taagtgtaat ctgctggagg gcgagccaag ggagttcgtg gagaactccg agtgcatcca   2880

gtgtcacccc gagtgcctgc ctcaggccat gaacatcacc tgtacaggcc gcggccccga   2940

caattgcatc cagtgtgccc actatatcga tggccctcac tgcgtgaaga cctgtccagc   3000

cggcgtgatg ggcgagaaca atacactggt gtggaagtac gcagacgcag gacacgtgtg   3060

ccacctgtgc caccccaatt gcacctatgg ctgtacagga ccaggcctgg agggatgccc   3120

aaccaacggc cctaagatcc caagcatcgc cacaggcatg gtgggggcac tgctgctgct   3180

gctggtggtg gctctgggga ttgggctgtt tatgagaagg taa                     3223


<210>  6
<211>  615
<212>  DNA
<213>  Artificial

<220>
<223>  ڲλĺ

<400>  6
tttaaatcgg atccgcggcc gcgcccctct ccctcccccc cccctaacgt tactggccga     60

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg    120

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg    180

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt    240

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac    300

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca    360

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg    420

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg    480

ggatctgatc tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaaa    540

cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg atgataatat    600

ggccacaacc atggc                                                     615


<210>  7
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  ĵİ

<400>  7

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


