                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Muenchen
 
<120>  Novel IGFR-like 2 receptor and uses thereof

<130>  HEL15880PCT

<150>  EP 17 153 782.2
<151>  2017-01-30

<150>  LU 100143
<151>  2017-03-16

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  3090
<212>  DNA
<213>  human

<400>  1
atgctgttcc gcgcccgggg gccggtacgg ggcaggggct gggggcggcc ggcggaggct       60

ccccgccgcg ggcgctcgcc gccctggagc cccgcctgga tttgctgctg ggcgctcgcc      120

ggctgccagg cggcctgggc tggggacctg ccctcctcct ccagccgccc gcttcctcct      180

tgccaggaga aagattatca ctttgaatat acggaatgtg atagcagtgg ctccaggtgg      240

agagttgcca ttccaaattc tgcagtggac tgctctggcc tgcctgaccc agtgagaggc      300

aaagaatgca ctttctcctg tgcttctgga gagtatctag aaatgaagaa ccaggtatgc      360

agtaagtgtg gtgaaggcac ctattccttg ggcagtggca tcaaatttga tgaatgggat      420

gaattgccgg caggattttc taacatcgca acattcatgg acactgtggt gggcccttct      480

gacagcaggc cagacggctg taacaactct tcttggatcc ctcgtggaaa ctacatagaa      540

tctaatcgtg atgactgcac ggtgtctttg atctatgctg tgcaccttaa gaagtcaggc      600

tatgtcttct ttgagtacca gtatgtcgac aacaacatct tctttgagtt ctttattcaa      660

aatgatcagt gccaggagat ggacaccacc actgacaagt gggtaaaact tacagacaat      720

ggagaatggg gctctcattc tgtaatgctg aaatcaggca caaacatact ctactggaga      780

actacaggca tccttatggg ttctaaggcg gtcaagcctg tgctggtaaa aaatatcaca      840

attgaagggg tggcgtacac atcagaatgt tttccttgca agccaggcac attcagcaac      900

aaaccaggtt cattcaactg ccaggtgtgt cccagaaaca cctattctga gaaaggagcc      960

aaagaatgta taaggtgtaa agacgactct caattttcag aggaaggatc cagtgagtgt     1020

acagagcgcc ctccctgtac cacaaaagac tatttccaga tccatactcc atgtgatgaa     1080

gaaggaaaga cacagataat gtacaagtgg atagagccca aaatctgccg ggaggatctc     1140

acagatgcta ttagattgcc cccttctgga gagaagaagg attgtccgcc ttgcaaccct     1200

ggattttata acaatggatc atcttcttgc catccctgtc ctcctggaac attttcagat     1260

ggaaccaaag aatgtagacc atgtccagca ggaacggagc ctgcacttgg ctttgaatat     1320

aaatggtgga atgtccttcc tggcaacatg aaaacttcct gcttcaatgt tgggaattca     1380

aagtgcgatg gaatgaatgg ttgggaggtg gctggagatc atatccagag tggggctgga     1440

ggttctgaca atgattacct gatcttaaac ttgcatatcc caggatttaa accaccaaca     1500

tctatgactg gagccacggg ttctgaacta ggaagaataa catttgtctt tgagaccctc     1560

tgttcagctg actgtgtttt gtacttcatg gtggatatta atagaaaaag tacaaatgtg     1620

gtagaatcgt ggggtggaac caaagaaaaa caagcttaca cccatatcat cttcaagaat     1680

gcaactttta catttacatg ggcattccag agaactaatc agggtcaaga taatagacgg     1740

ttcatcaatg acatggtgaa gatttattct atcacagcca ctaatgcagt tgatggggtg     1800

gcgtcctcat gccgtgcctg tgccctcggt tctgaacagt cgggttcatc gtgtgtcccc     1860

tgccctccag gccactacat tgagaaagaa accaaccagt gcaaggaatg tccacctgac     1920

acctacctgt ccatacatca ggtctatggc aaagaggctt gtattccatg cgggcctggg     1980

agtaaaaaca atcaggacca ttcggtttgc tatagtgact gctttttcta ccatgaaaaa     2040

gaaaatcaga gtttgcacta tgactttagc aacctcagca gtgtgggctc attaatgaat     2100

ggccccagct tcacctccaa aggaacaaaa tacttccatt tcttcaatat cagtttatgt     2160

gggcatgagg ggaagaagat ggctctctgt accaacaata taacagactt tacagtaaaa     2220

gaaatagtgg cagggtcaga tgattacaca aatttggtag gggcatttgt atgccagtca     2280

acaattattc cttctgaaag taagggtttc cgagcagcct tatcatcaca atccatcatt     2340

ctggcagata cattcatagg agtcacagtt gaaaccacat tgaaaaatat taatataaaa     2400

gaagatatgt tcccagttcc aacaagccaa ataccagatg tgcatttctt ttataagtct     2460

tctacagcaa caacatcttg tattaatggc cgatcaactg ctgtgaaaat gaggtgtaat     2520

cctactaaat ctggagcagg agtgatttca gtccccagca agtgcccagc aggtacctgt     2580

gatgggtgta cgttctattt cctgtgggag agtgctgaag cttgccctct gtgtacggag     2640

catgacttcc atgagattga gggagcctgc aagagaggat ttcaggaaac cttgtatgtg     2700

tggaatgaac ctaaatggtg cattaaagga atttctttgc ctgagaaaaa gttggcaacc     2760

tgtgaaacgg ttgacttttg gctgaaggtg ggagccggtg tgggagcttt tactgccgtt     2820

ttgctggtgg ctctgacctg ctacttctgg aaaaagaatc aaaaactgga atacaaatat     2880

tccaagttag taatgacgac taactcaaaa gagtgtgaac tcccggctgc agacagttgt     2940

gctatcatgg aaggagaaga taatgaagag gaagttgtat attccaataa acagtcacta     3000

ctaggaaaac tcaaatcttt ggcaaccaag gaaaaagaag accattttga atctgttcaa     3060

ctgaaaacct caagatcccc aaatatatga                                      3090


<210>  2
<211>  1029
<212>  PRT
<213>  human

<400>  2

Met Leu Phe Arg Ala Arg Gly Pro Val Arg Gly Arg Gly Trp Gly Arg 
1               5                   10                  15      


Pro Ala Glu Ala Pro Arg Arg Gly Arg Ser Pro Pro Trp Ser Pro Ala 
            20                  25                  30          


Trp Ile Cys Cys Trp Ala Leu Ala Gly Cys Gln Ala Ala Trp Ala Gly 
        35                  40                  45              


Asp Leu Pro Ser Ser Ser Ser Arg Pro Leu Pro Pro Cys Gln Glu Lys 
    50                  55                  60                  


Asp Tyr His Phe Glu Tyr Thr Glu Cys Asp Ser Ser Gly Ser Arg Trp 
65                  70                  75                  80  


Arg Val Ala Ile Pro Asn Ser Ala Val Asp Cys Ser Gly Leu Pro Asp 
                85                  90                  95      


Pro Val Arg Gly Lys Glu Cys Thr Phe Ser Cys Ala Ser Gly Glu Tyr 
            100                 105                 110         


Leu Glu Met Lys Asn Gln Val Cys Ser Lys Cys Gly Glu Gly Thr Tyr 
        115                 120                 125             


Ser Leu Gly Ser Gly Ile Lys Phe Asp Glu Trp Asp Glu Leu Pro Ala 
    130                 135                 140                 


Gly Phe Ser Asn Ile Ala Thr Phe Met Asp Thr Val Val Gly Pro Ser 
145                 150                 155                 160 


Asp Ser Arg Pro Asp Gly Cys Asn Asn Ser Ser Trp Ile Pro Arg Gly 
                165                 170                 175     


Asn Tyr Ile Glu Ser Asn Arg Asp Asp Cys Thr Val Ser Leu Ile Tyr 
            180                 185                 190         


Ala Val His Leu Lys Lys Ser Gly Tyr Val Phe Phe Glu Tyr Gln Tyr 
        195                 200                 205             


Val Asp Asn Asn Ile Phe Phe Glu Phe Phe Ile Gln Asn Asp Gln Cys 
    210                 215                 220                 


Gln Glu Met Asp Thr Thr Thr Asp Lys Trp Val Lys Leu Thr Asp Asn 
225                 230                 235                 240 


Gly Glu Trp Gly Ser His Ser Val Met Leu Lys Ser Gly Thr Asn Ile 
                245                 250                 255     


Leu Tyr Trp Arg Thr Thr Gly Ile Leu Met Gly Ser Lys Ala Val Lys 
            260                 265                 270         


Pro Val Leu Val Lys Asn Ile Thr Ile Glu Gly Val Ala Tyr Thr Ser 
        275                 280                 285             


Glu Cys Phe Pro Cys Lys Pro Gly Thr Phe Ser Asn Lys Pro Gly Ser 
    290                 295                 300                 


Phe Asn Cys Gln Val Cys Pro Arg Asn Thr Tyr Ser Glu Lys Gly Ala 
305                 310                 315                 320 


Lys Glu Cys Ile Arg Cys Lys Asp Asp Ser Gln Phe Ser Glu Glu Gly 
                325                 330                 335     


Ser Ser Glu Cys Thr Glu Arg Pro Pro Cys Thr Thr Lys Asp Tyr Phe 
            340                 345                 350         


Gln Ile His Thr Pro Cys Asp Glu Glu Gly Lys Thr Gln Ile Met Tyr 
        355                 360                 365             


Lys Trp Ile Glu Pro Lys Ile Cys Arg Glu Asp Leu Thr Asp Ala Ile 
    370                 375                 380                 


Arg Leu Pro Pro Ser Gly Glu Lys Lys Asp Cys Pro Pro Cys Asn Pro 
385                 390                 395                 400 


Gly Phe Tyr Asn Asn Gly Ser Ser Ser Cys His Pro Cys Pro Pro Gly 
                405                 410                 415     


Thr Phe Ser Asp Gly Thr Lys Glu Cys Arg Pro Cys Pro Ala Gly Thr 
            420                 425                 430         


Glu Pro Ala Leu Gly Phe Glu Tyr Lys Trp Trp Asn Val Leu Pro Gly 
        435                 440                 445             


Asn Met Lys Thr Ser Cys Phe Asn Val Gly Asn Ser Lys Cys Asp Gly 
    450                 455                 460                 


Met Asn Gly Trp Glu Val Ala Gly Asp His Ile Gln Ser Gly Ala Gly 
465                 470                 475                 480 


Gly Ser Asp Asn Asp Tyr Leu Ile Leu Asn Leu His Ile Pro Gly Phe 
                485                 490                 495     


Lys Pro Pro Thr Ser Met Thr Gly Ala Thr Gly Ser Glu Leu Gly Arg 
            500                 505                 510         


Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Ala Asp Cys Val Leu Tyr 
        515                 520                 525             


Phe Met Val Asp Ile Asn Arg Lys Ser Thr Asn Val Val Glu Ser Trp 
    530                 535                 540                 


Gly Gly Thr Lys Glu Lys Gln Ala Tyr Thr His Ile Ile Phe Lys Asn 
545                 550                 555                 560 


Ala Thr Phe Thr Phe Thr Trp Ala Phe Gln Arg Thr Asn Gln Gly Gln 
                565                 570                 575     


Asp Asn Arg Arg Phe Ile Asn Asp Met Val Lys Ile Tyr Ser Ile Thr 
            580                 585                 590         


Ala Thr Asn Ala Val Asp Gly Val Ala Ser Ser Cys Arg Ala Cys Ala 
        595                 600                 605             


Leu Gly Ser Glu Gln Ser Gly Ser Ser Cys Val Pro Cys Pro Pro Gly 
    610                 615                 620                 


His Tyr Ile Glu Lys Glu Thr Asn Gln Cys Lys Glu Cys Pro Pro Asp 
625                 630                 635                 640 


Thr Tyr Leu Ser Ile His Gln Val Tyr Gly Lys Glu Ala Cys Ile Pro 
                645                 650                 655     


Cys Gly Pro Gly Ser Lys Asn Asn Gln Asp His Ser Val Cys Tyr Ser 
            660                 665                 670         


Asp Cys Phe Phe Tyr His Glu Lys Glu Asn Gln Ser Leu His Tyr Asp 
        675                 680                 685             


Phe Ser Asn Leu Ser Ser Val Gly Ser Leu Met Asn Gly Pro Ser Phe 
    690                 695                 700                 


Thr Ser Lys Gly Thr Lys Tyr Phe His Phe Phe Asn Ile Ser Leu Cys 
705                 710                 715                 720 


Gly His Glu Gly Lys Lys Met Ala Leu Cys Thr Asn Asn Ile Thr Asp 
                725                 730                 735     


Phe Thr Val Lys Glu Ile Val Ala Gly Ser Asp Asp Tyr Thr Asn Leu 
            740                 745                 750         


Val Gly Ala Phe Val Cys Gln Ser Thr Ile Ile Pro Ser Glu Ser Lys 
        755                 760                 765             


Gly Phe Arg Ala Ala Leu Ser Ser Gln Ser Ile Ile Leu Ala Asp Thr 
    770                 775                 780                 


Phe Ile Gly Val Thr Val Glu Thr Thr Leu Lys Asn Ile Asn Ile Lys 
785                 790                 795                 800 


Glu Asp Met Phe Pro Val Pro Thr Ser Gln Ile Pro Asp Val His Phe 
                805                 810                 815     


Phe Tyr Lys Ser Ser Thr Ala Thr Thr Ser Cys Ile Asn Gly Arg Ser 
            820                 825                 830         


Thr Ala Val Lys Met Arg Cys Asn Pro Thr Lys Ser Gly Ala Gly Val 
        835                 840                 845             


Ile Ser Val Pro Ser Lys Cys Pro Ala Gly Thr Cys Asp Gly Cys Thr 
    850                 855                 860                 


Phe Tyr Phe Leu Trp Glu Ser Ala Glu Ala Cys Pro Leu Cys Thr Glu 
865                 870                 875                 880 


His Asp Phe His Glu Ile Glu Gly Ala Cys Lys Arg Gly Phe Gln Glu 
                885                 890                 895     


Thr Leu Tyr Val Trp Asn Glu Pro Lys Trp Cys Ile Lys Gly Ile Ser 
            900                 905                 910         


Leu Pro Glu Lys Lys Leu Ala Thr Cys Glu Thr Val Asp Phe Trp Leu 
        915                 920                 925             


Lys Val Gly Ala Gly Val Gly Ala Phe Thr Ala Val Leu Leu Val Ala 
    930                 935                 940                 


Leu Thr Cys Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr 
945                 950                 955                 960 


Ser Lys Leu Val Met Thr Thr Asn Ser Lys Glu Cys Glu Leu Pro Ala 
                965                 970                 975     


Ala Asp Ser Cys Ala Ile Met Glu Gly Glu Asp Asn Glu Glu Glu Val 
            980                 985                 990         


Val Tyr Ser Asn Lys Gln Ser Leu  Leu Gly Lys Leu Lys  Ser Leu Ala 
        995                 1000                 1005             


Thr Lys  Glu Lys Glu Asp His  Phe Glu Ser Val Gln  Leu Lys Thr 
    1010                 1015                 1020             


Ser Arg  Ser Pro Asn Ile 
    1025                 


<210>  3
<211>  3042
<212>  DNA
<213>  human

<400>  3
atggctgagc ctgggcacag ccaccatctc tccgccagag tcaggggaag aactgagagg       60

cgcatacccc ggctgtggcg gctgctgctc tgggctggga ccgccttcca ggtgacccag      120

ggaacgggac cggagcttca tgcctgcaaa gagtctgagt accactatga gtacacggcg      180

tgtgacagca cgggttccag gtggagggtc gccgtgccgc ataccccggg cctgtgcacc      240

agcctgcctg accccatcaa gggcaccgag tgctccttct cctgcaacgc cggggagttt      300

ctggatatga aggaccagtc atgtaagcca tgcgctgagg gccgctactc cctcggcaca      360

ggcattcggt ttgatgagtg ggatgagctg ccccatggct ttgccagcct ctcagccaac      420

atggagctgg atgacagtgc tgctgagtcc accgggaact gtacttcgtc caagtgggtt      480

ccccggggcg actacatcgc ctccaacacg gacgaatgca cagccacact gatgtacgcc      540

gtcaacctga agcaatctgg caccgttaac ttcgaatact actatccaga ctccagcatc      600

atctttgagt ttttcgttca gaatgaccag tgccagccca atgcagatga ctccaggtgg      660

atgaagacca cagagaaagg atgggaattc cacagtgtgg agctaaatcg aggcaataat      720

gtcctctatt ggagaaccac agccttctca gtatggacca aagtacccaa gcctgtgctg      780

gtgagaaaca ttgccataac aggggtggcc tacacttcag aatgcttccc ctgcaaacct      840

ggcacgtatg cagacaagca gggctcctct ttctgcaaac tttgcccagc caactcttat      900

tcaaataaag gagaaacttc ttgccaccag tgtgaccctg acaaatactc agagaaagga      960

tcttcttcct gtaacgtgcg cccagcttgc acagacaaag attatttcta cacacacacg     1020

gcctgcgatg ccaacggaga gacacaactc atgtacaaat gggccaagcc gaaaatctgt     1080

agcgaggacc ttgagggggc agtgaagctg cctgcctctg gtgtgaagac ccactgccca     1140

ccctgcaacc caggcttctt caaaaccaac aacagcacct gccagccctg cccatatggt     1200

tcctactcca atggctcaga ctgtacccgc tgccctgcag ggactgaacc tgctgtggga     1260

tttgaataca aatggtggaa cacgctgccc acaaacatgg aaacgaccgt tctcagtggg     1320

atcaacttcg agtacaaggg catgacaggc tgggaggtgg ctggtgatca catttacaca     1380

gctgctggag cctcagacaa tgacttcatg attctcactc tggttgtgcc aggatttaga     1440

cctccgcagt cggtgatggc agacacagag aataaagagg tggccagaat cacatttgtc     1500

tttgagaccc tctgttctgt gaactgtgag ctctacttca tggtgggtgt gaattctagg     1560

accaacactc ctgtggagac gtggaaaggt tccaaaggca aacagtccta tacctacatc     1620

attgaggaga acactaccac gagcttcacc tgggccttcc agaggaccac ttttcatgag     1680

gcaagcagga agtacaccaa tgacgttgcc aagatctact ccatcaatgt caccaatgtt     1740

atgaatggtg tggcctccta ctgccgtccc tgtgccctag aagcctctga tgtgggctcc     1800

tcctgcacct cttgtcctgc tggttactat attgaccgag attcaggaac ctgccactcc     1860

tgccccacta acacaattct gaaagcccac cagccttatg gtgtccaggc ctgtgtgccc     1920

tgtggtccag ggaccaagaa caacaagatc cactctctgt gctacaacga ttgcaccttc     1980

tcacgcaaca ctccgaccag gactttcaac tacaacttct ccgctttggc aaacactgtc     2040

actcttgctg gagggccaag cttcacttcc aaagggctga aatacttcca tcactttacc     2100

ctcagtctct gtggaaacca gggtaggaaa atgtctgtgt gcaccgacaa tgtcactgac     2160

ctccggattc ctgagggtga gtcagggttc tccaaatcta tcacagccta cgtctgccag     2220

gcagtcatca tccccccaga ggtgacaggc tacaaggccg gggtttcctc acagcctgtc     2280

agccttgctg atcgacttat tggggtgaca acagatatga ctctggatgg aatcacctcc     2340

ccagctgaac ttttccacct ggagtccttg ggaataccgg acgtgatctt cttttatagg     2400

tccaatgatg tgacccagtc ctgcagttct gggagatcaa ccaccatccg cgtcaggtgc     2460

agtccacaga aaactgtccc tggaagtttg ctgctgccag gaacgtgctc ggatgggacc     2520

tgtgatggct gcaacttcca cttcctgtgg gagagcgcgg ctgcttgccc gctctgctca     2580

gtggctgact accatgctat cgtcagcagc tgtgtggctg ggatccagaa gactacttac     2640

gtgtggcgag aacccaagct atgctctggt ggcatttctc tgcctgagca gagagtcacc     2700

atctgcaaaa ccatagattt ctggctgaaa gtgggcatct ctgcaggcac ctgtactgcc     2760

atcctgctca ccgtcttgac ctgctacttt tggaaaaaga atcaaaaact agagtacaag     2820

tactccaagc tggtgatgaa tgctactctc aaggactgtg acctgccagc agctgacagc     2880

tgcgccatca tggaaggcga ggatgtagag gacgacctca tctttaccag caagaagtca     2940

ctctttggga agatcaaatc atttacctcc aagaggactc ctgatggatt tgactcagtg     3000

ccgctgaaga catcctcagg aggcctagac atggacctgt ga                        3042


<210>  4
<211>  1013
<212>  PRT
<213>  human

<400>  4

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val 
145                 150                 155                 160 


Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr 
                165                 170                 175     


Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu 
            180                 185                 190         


Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe Val Gln Asn 
        195                 200                 205             


Asp Gln Cys Gln Pro Asn Ala Asp Asp Ser Arg Trp Met Lys Thr Thr 
    210                 215                 220                 


Glu Lys Gly Trp Glu Phe His Ser Val Glu Leu Asn Arg Gly Asn Asn 
225                 230                 235                 240 


Val Leu Tyr Trp Arg Thr Thr Ala Phe Ser Val Trp Thr Lys Val Pro 
                245                 250                 255     


Lys Pro Val Leu Val Arg Asn Ile Ala Ile Thr Gly Val Ala Tyr Thr 
            260                 265                 270         


Ser Glu Cys Phe Pro Cys Lys Pro Gly Thr Tyr Ala Asp Lys Gln Gly 
        275                 280                 285             


Ser Ser Phe Cys Lys Leu Cys Pro Ala Asn Ser Tyr Ser Asn Lys Gly 
    290                 295                 300                 


Glu Thr Ser Cys His Gln Cys Asp Pro Asp Lys Tyr Ser Glu Lys Gly 
305                 310                 315                 320 


Ser Ser Ser Cys Asn Val Arg Pro Ala Cys Thr Asp Lys Asp Tyr Phe 
                325                 330                 335     


Tyr Thr His Thr Ala Cys Asp Ala Asn Gly Glu Thr Gln Leu Met Tyr 
            340                 345                 350         


Lys Trp Ala Lys Pro Lys Ile Cys Ser Glu Asp Leu Glu Gly Ala Val 
        355                 360                 365             


Lys Leu Pro Ala Ser Gly Val Lys Thr His Cys Pro Pro Cys Asn Pro 
    370                 375                 380                 


Gly Phe Phe Lys Thr Asn Asn Ser Thr Cys Gln Pro Cys Pro Tyr Gly 
385                 390                 395                 400 


Ser Tyr Ser Asn Gly Ser Asp Cys Thr Arg Cys Pro Ala Gly Thr Glu 
                405                 410                 415     


Pro Ala Val Gly Phe Glu Tyr Lys Trp Trp Asn Thr Leu Pro Thr Asn 
            420                 425                 430         


Met Glu Thr Thr Val Leu Ser Gly Ile Asn Phe Glu Tyr Lys Gly Met 
        435                 440                 445             


Thr Gly Trp Glu Val Ala Gly Asp His Ile Tyr Thr Ala Ala Gly Ala 
    450                 455                 460                 


Ser Asp Asn Asp Phe Met Ile Leu Thr Leu Val Val Pro Gly Phe Arg 
465                 470                 475                 480 


Pro Pro Gln Ser Val Met Ala Asp Thr Glu Asn Lys Glu Val Ala Arg 
                485                 490                 495     


Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Val Asn Cys Glu Leu Tyr 
            500                 505                 510         


Phe Met Val Gly Val Asn Ser Arg Thr Asn Thr Pro Val Glu Thr Trp 
        515                 520                 525             


Lys Gly Ser Lys Gly Lys Gln Ser Tyr Thr Tyr Ile Ile Glu Glu Asn 
    530                 535                 540                 


Thr Thr Thr Ser Phe Thr Trp Ala Phe Gln Arg Thr Thr Phe His Glu 
545                 550                 555                 560 


Ala Ser Arg Lys Tyr Thr Asn Asp Val Ala Lys Ile Tyr Ser Ile Asn 
                565                 570                 575     


Val Thr Asn Val Met Asn Gly Val Ala Ser Tyr Cys Arg Pro Cys Ala 
            580                 585                 590         


Leu Glu Ala Ser Asp Val Gly Ser Ser Cys Thr Ser Cys Pro Ala Gly 
        595                 600                 605             


Tyr Tyr Ile Asp Arg Asp Ser Gly Thr Cys His Ser Cys Pro Thr Asn 
    610                 615                 620                 


Thr Ile Leu Lys Ala His Gln Pro Tyr Gly Val Gln Ala Cys Val Pro 
625                 630                 635                 640 


Cys Gly Pro Gly Thr Lys Asn Asn Lys Ile His Ser Leu Cys Tyr Asn 
                645                 650                 655     


Asp Cys Thr Phe Ser Arg Asn Thr Pro Thr Arg Thr Phe Asn Tyr Asn 
            660                 665                 670         


Phe Ser Ala Leu Ala Asn Thr Val Thr Leu Ala Gly Gly Pro Ser Phe 
        675                 680                 685             


Thr Ser Lys Gly Leu Lys Tyr Phe His His Phe Thr Leu Ser Leu Cys 
    690                 695                 700                 


Gly Asn Gln Gly Arg Lys Met Ser Val Cys Thr Asp Asn Val Thr Asp 
705                 710                 715                 720 


Leu Arg Ile Pro Glu Gly Glu Ser Gly Phe Ser Lys Ser Ile Thr Ala 
                725                 730                 735     


Tyr Val Cys Gln Ala Val Ile Ile Pro Pro Glu Val Thr Gly Tyr Lys 
            740                 745                 750         


Ala Gly Val Ser Ser Gln Pro Val Ser Leu Ala Asp Arg Leu Ile Gly 
        755                 760                 765             


Val Thr Thr Asp Met Thr Leu Asp Gly Ile Thr Ser Pro Ala Glu Leu 
    770                 775                 780                 


Phe His Leu Glu Ser Leu Gly Ile Pro Asp Val Ile Phe Phe Tyr Arg 
785                 790                 795                 800 


Ser Asn Asp Val Thr Gln Ser Cys Ser Ser Gly Arg Ser Thr Thr Ile 
                805                 810                 815     


Arg Val Arg Cys Ser Pro Gln Lys Thr Val Pro Gly Ser Leu Leu Leu 
            820                 825                 830         


Pro Gly Thr Cys Ser Asp Gly Thr Cys Asp Gly Cys Asn Phe His Phe 
        835                 840                 845             


Leu Trp Glu Ser Ala Ala Ala Cys Pro Leu Cys Ser Val Ala Asp Tyr 
    850                 855                 860                 


His Ala Ile Val Ser Ser Cys Val Ala Gly Ile Gln Lys Thr Thr Tyr 
865                 870                 875                 880 


Val Trp Arg Glu Pro Lys Leu Cys Ser Gly Gly Ile Ser Leu Pro Glu 
                885                 890                 895     


Gln Arg Val Thr Ile Cys Lys Thr Ile Asp Phe Trp Leu Lys Val Gly 
            900                 905                 910         


Ile Ser Ala Gly Thr Cys Thr Ala Ile Leu Leu Thr Val Leu Thr Cys 
        915                 920                 925             


Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu 
    930                 935                 940                 


Val Met Asn Ala Thr Leu Lys Asp Cys Asp Leu Pro Ala Ala Asp Ser 
945                 950                 955                 960 


Cys Ala Ile Met Glu Gly Glu Asp Val Glu Asp Asp Leu Ile Phe Thr 
                965                 970                 975     


Ser Lys Lys Ser Leu Phe Gly Lys Ile Lys Ser Phe Thr Ser Lys Arg 
            980                 985                 990         


Thr Pro Asp Gly Phe Asp Ser Val  Pro Leu Lys Thr Ser  Ser Gly Gly 
        995                 1000                 1005             


Leu Asp  Met Asp Leu 
    1010             


