                         SEQUENCE LISTING

<110>  Commonwealth Scientific and Industrial Research 
       Organisation
 
<120>  Nitrogenase

<130>  527134

<150>  AU2017900359
<151>  2017-02-06

<160>  186   

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu Gln Gln Lys Pro 
            20                  25                  


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative sequence

<400>  2

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro 
            20                  25                  30      


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif


<220>
<221>  X
<222>  (1)..(1)
<223>  Any amino acid

<220>
<221>  X
<222>  (3)..(5)
<223>  Any amino acid

<220>
<221>  X
<222>  (8)..(8)
<223>  Any amino acid

<400>  3

Xaa Arg Xaa Xaa Xaa Ser Ser Xaa 
1               5               


<210>  4
<211>  2346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector sequence

<400>  4
ctcctgtggt tggcatgcac atacaaatgg acgaacggat aaaccttttc acgccctttt       60

aaatatccga ttattctaat aaacgctctt ttctcttagg tttacccgcc aatatatcct      120

gtcaaacact gatagtttaa actgaaggcg ggaaacgaca atctgctagt ggatctccca      180

gtcacgacgt tgtaaaacgg gcgccccgcg gaaagctttc gacgaattaa ttccaatccc      240

acaaaaatct gagcttaaca gcacagttgc tcctctcaga gcagaatcgg gtattcaaca      300

ccctcatatc aactactacg ttgtgtataa cggtccacat gccggtatat acgatgactg      360

gggttgtaca aaggcggcaa caaacggcgt tcccggagtt gcacacaaga aatttgccac      420

tattacagag gcaagagcag cagctgacgc gtacacaaca agtcagcaaa cagacaggtt      480

gaacttcatc cccaaaggag aagctcaact caagcccaag agctttgcta aggccctaac      540

aagcccacca aagcaaaaag cccactggct cacgctagga accaaaaggc ccagcagtga      600

tccagcccca aaagagatct cctttgcccc ggagattaca atggacgatt tcctctatct      660

ttacgatcta ggaaggaagt tcgaaggtga aggtgacgac actatgttca ccactgataa      720

tgagaaggtt agcctcttca atttcagaaa gaatgctgac ccacagatgg ttagagaggc      780

ctacgcagca ggtctcatca agacgatcta cccgagtaac aatctccagg agatcaaata      840

ccttcccaag aaggttaaag atgcagtcaa aagattcagg actaattgca tcaagaacac      900

agagaaagac atatttctca agatcagaag tactattcca gtatggacga ttcaaggctt      960

gcttcataaa ccaaggcaag taatagagat tggagtctct aaaaaggtag ttcctactga     1020

atctaaggcc atgcatggag tctaagattc aaatcgagga tctaacagaa ctcgccgtga     1080

agactggcga acagttcata cagagtcttt tacgactcaa tgacaagaag aaaatcttcg     1140

tcaacatggt ggagcacgac actctggtct actccaaaaa tgtcaaagat acagtctcag     1200

aagaccaaag ggctattgag acttttcaac aaaggataat ttcgggaaac ctcctcggat     1260

tccattgccc agctatctgt cacttcatcg aaaggacagt agaaaaggaa ggtggctcct     1320

acaaatgcca tcattgcgat aaaggaaagg ctatcattca agatctctct gccgacagtg     1380

gtcccaaaga tggaccccca cccacgagga gcatcgtgga aaaagaagac gttccaacca     1440

cgtcttcaaa gcaagtggat tgatgtgaca tctccactga cgtaagggat gacgcacaat     1500

cccactatcc ttcgcaagac ccttcctcta tataaggaag ttcatttcat ttggagagga     1560

cacgctcgag taatacgact cactataggg agaccacaac ggtttccctc tagaaataat     1620

tttgtttaac tttaagaagg agatatacca tgggcttgtc actactacgt caatctataa     1680

gatttttcaa gccagccaca agaactttgt gtagctctag atatctgctt gagcaaaaac     1740

ccggcgcgcc ggctgctaac aaagcccgaa aggaagctga gttggctgct gccaccgctg     1800

agcaataact agcataaccc cttggggcct ctaaacgggt cttgaggggt tttttgctgc     1860

ttaagattga atcctgttgc cggtcttgcg atgattatca tataatttct gttgaattac     1920

gttaagcatg taataattaa catgtaatgc atgacgttat ttatgagatg ggtttttatg     1980

attagagtcc cgcaattata catttaatac gcgatagaaa acaaaatata gcgcgcaaac     2040

taggataaat tatcgcgcgc ggtgtcatct atgttactag atccctaggg aagttcctat     2100

tccgaagttc ctattctctg aaaagtatag gaacttcttt gcgtattggg cgctcttggc     2160

ctttttggcc accggtcgta cggttaaaac caccccagta cattaaaaac gtccgcaatg     2220

tgttattaag ttgtctaagc gtcaatttgt ttacaccaca atatatcctg ccaccagcca     2280

gccaacagct ccccgaccgg cagctcggca caaaatcacc actcgataca ggcagcccat     2340

cagtcc                                                                2346


<210>  5
<211>  293
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  5

Met Thr Met Arg Gln Cys Ala Ile Tyr Gly Lys Gly Gly Ile Gly Lys 
1               5                   10                  15      


Ser Thr Thr Thr Gln Asn Leu Val Ala Ala Leu Ala Glu Met Gly Lys 
            20                  25                  30          


Lys Val Met Ile Val Gly Cys Asp Pro Lys Ala Asp Ser Thr Arg Leu 
        35                  40                  45              


Ile Leu His Ala Lys Ala Gln Asn Thr Ile Met Glu Met Ala Ala Glu 
    50                  55                  60                  


Val Gly Ser Val Glu Asp Leu Glu Leu Glu Asp Val Leu Gln Ile Gly 
65                  70                  75                  80  


Tyr Gly Asp Val Arg Cys Ala Glu Ser Gly Gly Pro Glu Pro Gly Val 
                85                  90                  95      


Gly Cys Ala Gly Arg Gly Val Ile Thr Ala Ile Asn Phe Leu Glu Glu 
            100                 105                 110         


Glu Gly Ala Tyr Glu Asp Asp Leu Asp Phe Val Phe Tyr Asp Val Leu 
        115                 120                 125             


Gly Asp Val Val Cys Gly Gly Phe Ala Met Pro Ile Arg Glu Asn Lys 
    130                 135                 140                 


Ala Gln Glu Ile Tyr Ile Val Cys Ser Gly Glu Met Met Ala Met Tyr 
145                 150                 155                 160 


Ala Ala Asn Asn Ile Ser Lys Gly Ile Val Lys Tyr Ala Lys Ser Gly 
                165                 170                 175     


Lys Val Arg Leu Gly Gly Leu Ile Cys Asn Ser Arg Gln Thr Asp Arg 
            180                 185                 190         


Glu Asp Glu Leu Ile Ile Ala Leu Ala Glu Lys Leu Gly Thr Gln Met 
        195                 200                 205             


Ile His Phe Val Pro Arg Asp Asn Ile Val Gln Arg Ala Glu Ile Arg 
    210                 215                 220                 


Arg Met Thr Val Ile Glu Tyr Asp Pro Ala Cys Lys Gln Ala Asn Glu 
225                 230                 235                 240 


Tyr Arg Thr Leu Ala Gln Lys Ile Val Asn Asn Thr Met Lys Val Val 
                245                 250                 255     


Pro Thr Pro Cys Thr Met Asp Glu Leu Glu Ser Leu Leu Met Glu Phe 
            260                 265                 270         


Gly Ile Met Glu Glu Glu Asp Thr Ser Ile Ile Gly Lys Thr Ala Ala 
        275                 280                 285             


Glu Glu Asn Ala Ala 
    290             


<210>  6
<211>  483
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  6

Met Met Thr Asn Ala Thr Gly Glu Arg Asn Leu Ala Leu Ile Gln Glu 
1               5                   10                  15      


Val Leu Glu Val Phe Pro Glu Thr Ala Arg Lys Glu Arg Arg Lys His 
            20                  25                  30          


Met Met Val Ser Asp Pro Lys Met Lys Ser Val Gly Lys Cys Ile Ile 
        35                  40                  45              


Ser Asn Arg Lys Ser Gln Pro Gly Val Met Thr Val Arg Gly Cys Ala 
    50                  55                  60                  


Tyr Ala Gly Ser Lys Gly Val Val Phe Gly Pro Ile Lys Asp Met Ala 
65                  70                  75                  80  


His Ile Ser His Gly Pro Ala Gly Cys Gly Gln Tyr Ser Arg Ala Glu 
                85                  90                  95      


Arg Arg Asn Tyr Tyr Thr Gly Val Ser Gly Val Asp Ser Phe Gly Thr 
            100                 105                 110         


Leu Asn Phe Thr Ser Asp Phe Gln Glu Arg Asp Ile Val Phe Gly Gly 
        115                 120                 125             


Asp Lys Lys Leu Ser Lys Leu Ile Glu Glu Met Glu Leu Leu Phe Pro 
    130                 135                 140                 


Leu Thr Lys Gly Ile Thr Ile Gln Ser Glu Cys Pro Val Gly Leu Ile 
145                 150                 155                 160 


Gly Asp Asp Ile Ser Ala Val Ala Asn Ala Ser Ser Lys Ala Leu Asp 
                165                 170                 175     


Lys Pro Val Ile Pro Val Arg Cys Glu Gly Phe Arg Gly Val Ser Gln 
            180                 185                 190         


Ser Leu Gly His His Ile Ala Asn Asp Val Val Arg Asp Trp Ile Leu 
        195                 200                 205             


Asn Asn Arg Glu Gly Gln Pro Phe Glu Thr Thr Pro Tyr Asp Val Ala 
    210                 215                 220                 


Ile Ile Gly Asp Tyr Asn Ile Gly Gly Asp Ala Trp Ala Ser Arg Ile 
225                 230                 235                 240 


Leu Leu Glu Glu Met Gly Leu Arg Val Val Ala Gln Trp Ser Gly Asp 
                245                 250                 255     


Gly Thr Leu Val Glu Met Glu Asn Thr Pro Phe Val Lys Leu Asn Leu 
            260                 265                 270         


Val His Cys Tyr Arg Ser Met Asn Tyr Ile Ala Arg His Met Glu Glu 
        275                 280                 285             


Lys His Gln Ile Pro Trp Met Glu Tyr Asn Phe Phe Gly Pro Thr Lys 
    290                 295                 300                 


Ile Ala Glu Ser Leu Arg Lys Ile Ala Asp Gln Phe Asp Asp Thr Ile 
305                 310                 315                 320 


Arg Ala Asn Ala Glu Ala Val Ile Ala Arg Tyr Glu Gly Gln Met Ala 
                325                 330                 335     


Ala Ile Ile Ala Lys Tyr Arg Pro Arg Leu Glu Gly Arg Lys Val Leu 
            340                 345                 350         


Leu Tyr Ile Gly Gly Leu Arg Pro Arg His Val Ile Gly Ala Tyr Glu 
        355                 360                 365             


Asp Leu Gly Met Glu Ile Ile Ala Ala Gly Tyr Glu Phe Ala His Asn 
    370                 375                 380                 


Asp Asp Tyr Asp Arg Thr Leu Pro Asp Leu Lys Glu Gly Thr Leu Leu 
385                 390                 395                 400 


Phe Asp Asp Ala Ser Ser Tyr Glu Leu Glu Ala Phe Val Lys Ala Leu 
                405                 410                 415     


Lys Pro Asp Leu Ile Gly Ser Gly Ile Lys Glu Lys Tyr Ile Phe Gln 
            420                 425                 430         


Lys Met Gly Val Pro Phe Arg Gln Met His Ser Trp Asp Tyr Ser Gly 
        435                 440                 445             


Pro Tyr His Gly Tyr Asp Gly Phe Ala Ile Phe Ala Arg Asp Met Asp 
    450                 455                 460                 


Met Thr Leu Asn Asn Pro Ala Trp Asn Glu Leu Thr Ala Pro Trp Leu 
465                 470                 475                 480 


Lys Ser Ala 
            


<210>  7
<211>  520
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  7

Met Ser Gln Thr Ile Asp Lys Ile Asn Ser Cys Tyr Pro Leu Phe Glu 
1               5                   10                  15      


Gln Asp Glu Tyr Gln Glu Leu Phe Arg Asn Lys Arg Gln Leu Glu Glu 
            20                  25                  30          


Ala His Asp Ala Gln Arg Val Gln Glu Val Phe Ala Trp Thr Thr Thr 
        35                  40                  45              


Ala Glu Tyr Glu Ala Leu Asn Phe Arg Arg Glu Ala Leu Thr Val Asp 
    50                  55                  60                  


Pro Ala Lys Ala Cys Gln Pro Leu Gly Ala Val Leu Cys Ser Leu Gly 
65                  70                  75                  80  


Phe Ala Asn Thr Leu Pro Tyr Val His Gly Ser Gln Gly Cys Val Ala 
                85                  90                  95      


Tyr Phe Arg Thr Tyr Phe Asn Arg His Phe Lys Glu Pro Ile Ala Cys 
            100                 105                 110         


Val Ser Asp Ser Met Thr Glu Asp Ala Ala Val Phe Gly Gly Asn Asn 
        115                 120                 125             


Asn Met Asn Leu Gly Leu Gln Asn Ala Ser Ala Leu Tyr Lys Pro Glu 
    130                 135                 140                 


Ile Ile Ala Val Ser Thr Thr Cys Met Ala Glu Val Ile Gly Asp Asp 
145                 150                 155                 160 


Leu Gln Ala Phe Ile Ala Asn Ala Lys Lys Asp Gly Phe Val Asp Ser 
                165                 170                 175     


Ser Ile Ala Val Pro His Ala His Thr Pro Ser Phe Ile Gly Ser His 
            180                 185                 190         


Val Thr Gly Trp Asp Asn Met Phe Glu Gly Phe Ala Lys Thr Phe Thr 
        195                 200                 205             


Ala Asp Tyr Gln Gly Gln Pro Gly Lys Leu Pro Lys Leu Asn Leu Val 
    210                 215                 220                 


Thr Gly Phe Glu Thr Tyr Leu Gly Asn Phe Arg Val Leu Lys Arg Met 
225                 230                 235                 240 


Met Glu Gln Met Ala Val Pro Cys Ser Leu Leu Ser Asp Pro Ser Glu 
                245                 250                 255     


Val Leu Asp Thr Pro Ala Asp Gly His Tyr Arg Met Tyr Ser Gly Gly 
            260                 265                 270         


Thr Thr Gln Gln Glu Met Lys Glu Ala Pro Asp Ala Ile Asp Thr Leu 
        275                 280                 285             


Leu Leu Gln Pro Trp Gln Leu Leu Lys Ser Lys Lys Val Val Gln Glu 
    290                 295                 300                 


Met Trp Asn Gln Pro Ala Thr Glu Val Ala Ile Pro Leu Gly Leu Ala 
305                 310                 315                 320 


Ala Thr Asp Glu Leu Leu Met Thr Val Ser Gln Leu Ser Gly Lys Pro 
                325                 330                 335     


Ile Ala Asp Ala Leu Thr Leu Glu Arg Gly Arg Leu Val Asp Met Met 
            340                 345                 350         


Leu Asp Ser His Thr Trp Leu His Gly Lys Lys Phe Gly Leu Tyr Gly 
        355                 360                 365             


Asp Pro Asp Phe Val Met Gly Leu Thr Arg Phe Leu Leu Glu Leu Gly 
    370                 375                 380                 


Cys Glu Pro Thr Val Ile Leu Ser His Asn Ala Asn Lys Arg Trp Gln 
385                 390                 395                 400 


Lys Ala Met Asn Lys Met Leu Asp Ala Ser Pro Tyr Gly Arg Asp Ser 
                405                 410                 415     


Glu Val Phe Ile Asn Cys Asp Leu Trp His Phe Arg Ser Leu Met Phe 
            420                 425                 430         


Thr Arg Gln Pro Asp Phe Met Ile Gly Asn Ser Tyr Gly Lys Phe Ile 
        435                 440                 445             


Gln Arg Asp Thr Leu Ala Lys Gly Lys Ala Phe Glu Val Pro Leu Ile 
    450                 455                 460                 


Arg Leu Gly Phe Pro Leu Phe Asp Arg His His Leu His Arg Gln Thr 
465                 470                 475                 480 


Thr Trp Gly Tyr Glu Gly Ala Met Asn Ile Val Thr Thr Leu Val Asn 
                485                 490                 495     


Ala Val Leu Glu Lys Leu Asp Ser Asp Thr Ser Gln Leu Gly Lys Thr 
            500                 505                 510         


Asp Tyr Ser Phe Asp Leu Val Arg 
        515                 520 


<210>  8
<211>  220
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  8

Met Ser Asp Asn Asp Thr Leu Phe Trp Arg Met Leu Ala Leu Phe Gln 
1               5                   10                  15      


Ser Leu Pro Asp Leu Gln Pro Ala Gln Ile Val Asp Trp Leu Ala Gln 
            20                  25                  30          


Glu Ser Gly Glu Thr Leu Thr Pro Glu Arg Leu Ala Thr Leu Thr Gln 
        35                  40                  45              


Pro Gln Leu Ala Ala Ser Phe Pro Ser Ala Thr Ala Val Met Ser Pro 
    50                  55                  60                  


Ala Arg Trp Ser Arg Val Met Ala Ser Leu Gln Gly Ala Leu Pro Ala 
65                  70                  75                  80  


His Leu Arg Ile Val Arg Pro Ala Gln Arg Thr Pro Gln Leu Leu Ala 
                85                  90                  95      


Ala Phe Cys Ser Gln Asp Gly Leu Val Ile Asn Gly His Phe Gly Gln 
            100                 105                 110         


Gly Arg Leu Phe Phe Ile Tyr Ala Phe Asp Glu Gln Gly Gly Trp Leu 
        115                 120                 125             


Tyr Asp Leu Arg Arg Tyr Pro Ser Ala Pro His Gln Gln Glu Ala Asn 
    130                 135                 140                 


Glu Val Arg Ala Arg Leu Ile Glu Asp Cys Gln Leu Leu Phe Cys Gln 
145                 150                 155                 160 


Glu Ile Gly Gly Pro Ala Ala Ala Arg Pro Ile Arg His Arg Ile His 
                165                 170                 175     


Pro Met Lys Ala Gln Pro Gly Thr Thr Ile Gln Ala Gln Cys Glu Ala 
            180                 185                 190         


Ile Asn Thr Leu Leu Ala Gly Arg Leu Pro Pro Trp Leu Ala Lys Arg 
        195                 200                 205             


Leu Asn Arg Asp Asn Pro Leu Glu Glu Arg Val Phe 
    210                 215                 220 


<210>  9
<211>  468
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  9

Met Thr Ser Cys Ser Ser Phe Ser Gly Gly Lys Ala Cys Arg Pro Ala 
1               5                   10                  15      


Asp Asp Ser Ala Leu Thr Pro Leu Val Ala Asp Lys Ala Ala Ala His 
            20                  25                  30          


Pro Cys Tyr Ser Arg His Gly His His Arg Phe Ala Arg Met His Leu 
        35                  40                  45              


Pro Val Ala Pro Ala Cys Asn Leu Gln Cys Asn Tyr Cys Asn Arg Lys 
    50                  55                  60                  


Phe Asp Cys Ser Asn Glu Ser Arg Pro Gly Val Ser Ser Thr Leu Leu 
65                  70                  75                  80  


Thr Pro Glu Gln Ala Val Val Lys Val Arg Gln Val Ala Gln Ala Ile 
                85                  90                  95      


Pro Gln Leu Ser Val Val Gly Ile Ala Gly Pro Gly Asp Pro Leu Ala 
            100                 105                 110         


Asn Ile Ala Arg Thr Phe Arg Thr Leu Glu Leu Ile Arg Glu Gln Leu 
        115                 120                 125             


Pro Asp Leu Lys Leu Cys Leu Ser Thr Asn Gly Leu Val Leu Pro Asp 
    130                 135                 140                 


Ala Val Asp Arg Leu Leu Asp Val Gly Val Asp His Val Thr Val Thr 
145                 150                 155                 160 


Ile Asn Thr Leu Asp Ala Glu Ile Ala Ala Gln Ile Tyr Ala Trp Leu 
                165                 170                 175     


Trp Leu Asp Gly Glu Arg Tyr Ser Gly Arg Glu Ala Gly Glu Ile Leu 
            180                 185                 190         


Ile Ala Arg Gln Leu Glu Gly Val Arg Arg Leu Thr Ala Lys Gly Val 
        195                 200                 205             


Leu Val Lys Ile Asn Ser Val Leu Ile Pro Gly Ile Asn Asp Ser Gly 
    210                 215                 220                 


Met Ala Gly Val Ser Arg Ala Leu Arg Ala Ser Gly Ala Phe Ile His 
225                 230                 235                 240 


Asn Ile Met Pro Leu Ile Ala Arg Pro Glu His Gly Thr Val Phe Gly 
                245                 250                 255     


Leu Asn Gly Gln Pro Glu Pro Asp Ala Glu Thr Leu Ala Ala Thr Arg 
            260                 265                 270         


Ser Arg Cys Gly Glu Val Met Pro Gln Met Thr His Cys His Gln Cys 
        275                 280                 285             


Arg Ala Asp Ala Ile Gly Met Leu Gly Glu Asp Arg Ser Gln Gln Phe 
    290                 295                 300                 


Thr Gln Leu Pro Ala Pro Glu Ser Leu Pro Ala Trp Leu Pro Ile Leu 
305                 310                 315                 320 


His Gln Arg Ala Gln Leu His Ala Ser Ile Ala Thr Arg Gly Glu Ser 
                325                 330                 335     


Glu Ala Asp Asp Ala Cys Leu Val Ala Val Ala Ser Ser Arg Gly Asp 
            340                 345                 350         


Val Ile Asp Cys His Phe Gly His Ala Asp Arg Phe Tyr Ile Tyr Ser 
        355                 360                 365             


Leu Ser Ala Ala Gly Met Val Leu Val Asn Glu Arg Phe Thr Pro Lys 
    370                 375                 380                 


Tyr Cys Gln Gly Arg Asp Asp Cys Glu Pro Gln Asp Asn Ala Ala Arg 
385                 390                 395                 400 


Phe Ala Ala Ile Leu Glu Leu Leu Ala Asp Val Lys Ala Val Phe Cys 
                405                 410                 415     


Val Arg Ile Gly His Thr Pro Trp Gln Gln Leu Glu Gln Glu Gly Ile 
            420                 425                 430         


Glu Pro Cys Val Asp Gly Ala Trp Arg Pro Val Ser Glu Val Leu Pro 
        435                 440                 445             


Ala Trp Trp Gln Gln Arg Arg Gly Ser Trp Pro Ala Ala Leu Pro His 
    450                 455                 460                 


Lys Gly Val Ala 
465             


<210>  10
<211>  457
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  10

Met Lys Gly Asn Glu Ile Leu Ala Leu Leu Asp Glu Pro Ala Cys Glu 
1               5                   10                  15      


His Asn His Lys Gln Lys Ser Gly Cys Ser Ala Pro Lys Pro Gly Ala 
            20                  25                  30          


Thr Ala Ala Gly Cys Ala Phe Asp Gly Ala Gln Ile Thr Leu Leu Pro 
        35                  40                  45              


Ile Ala Asp Val Ala His Leu Val His Gly Pro Ile Gly Cys Ala Gly 
    50                  55                  60                  


Ser Ser Trp Asp Asn Arg Gly Ser Ala Ser Ser Gly Pro Thr Leu Asn 
65                  70                  75                  80  


Arg Leu Gly Phe Thr Thr Asp Leu Asn Glu Gln Asp Val Ile Met Gly 
                85                  90                  95      


Arg Gly Glu Arg Arg Leu Phe His Ala Val Arg His Ile Val Thr Arg 
            100                 105                 110         


Tyr His Pro Ala Ala Val Phe Ile Tyr Asn Thr Cys Val Pro Ala Met 
        115                 120                 125             


Glu Gly Asp Asp Leu Glu Ala Val Cys Gln Ala Ala Gln Thr Ala Thr 
    130                 135                 140                 


Gly Val Pro Val Ile Ala Ile Asp Ala Ala Gly Phe Tyr Gly Ser Lys 
145                 150                 155                 160 


Asn Leu Gly Asn Arg Pro Ala Gly Asp Val Met Val Lys Arg Val Ile 
                165                 170                 175     


Gly Gln Arg Glu Pro Ala Pro Trp Pro Glu Ser Thr Leu Phe Ala Pro 
            180                 185                 190         


Glu Gln Arg His Asp Ile Gly Leu Ile Gly Glu Phe Asn Ile Ala Gly 
        195                 200                 205             


Glu Phe Trp His Ile Gln Pro Leu Leu Asp Glu Leu Gly Ile Arg Val 
    210                 215                 220                 


Leu Gly Ser Leu Ser Gly Asp Gly Arg Phe Ala Glu Ile Gln Thr Met 
225                 230                 235                 240 


His Arg Ala Gln Ala Asn Met Leu Val Cys Ser Arg Ala Leu Ile Asn 
                245                 250                 255     


Val Ala Arg Ala Leu Glu Gln Arg Tyr Gly Thr Pro Trp Phe Glu Gly 
            260                 265                 270         


Ser Phe Tyr Gly Ile Arg Ala Thr Ser Asp Ala Leu Arg Gln Leu Ala 
        275                 280                 285             


Ala Leu Leu Gly Asp Asp Asp Leu Arg Gln Arg Thr Glu Ala Leu Ile 
    290                 295                 300                 


Ala Arg Glu Glu Gln Ala Ala Glu Leu Ala Leu Gln Pro Trp Arg Glu 
305                 310                 315                 320 


Gln Leu Arg Gly Arg Lys Ala Leu Leu Tyr Thr Gly Gly Val Lys Ser 
                325                 330                 335     


Trp Ser Val Val Ser Ala Leu Gln Asp Leu Gly Met Thr Val Val Ala 
            340                 345                 350         


Thr Gly Thr Arg Lys Ser Thr Glu Glu Asp Lys Gln Arg Ile Arg Glu 
        355                 360                 365             


Leu Met Gly Glu Glu Ala Val Met Leu Glu Glu Gly Asn Ala Arg Thr 
    370                 375                 380                 


Leu Leu Asp Val Val Tyr Arg Tyr Gln Ala Asp Leu Met Ile Ala Gly 
385                 390                 395                 400 


Gly Arg Asn Met Tyr Thr Ala Tyr Lys Ala Arg Leu Pro Phe Leu Asp 
                405                 410                 415     


Ile Asn Gln Glu Arg Glu His Ala Phe Ala Gly Tyr Gln Gly Ile Val 
            420                 425                 430         


Thr Leu Ala Arg Gln Leu Cys Gln Thr Ile Asn Ser Pro Ile Trp Pro 
        435                 440                 445             


Gln Thr His Ser Arg Ala Pro Trp Arg 
    450                 455         


<210>  11
<211>  461
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  11

Met Ala Asp Ile Phe Arg Thr Asp Lys Pro Leu Ala Val Ser Pro Ile 
1               5                   10                  15      


Lys Thr Gly Gln Pro Leu Gly Ala Ile Leu Ala Ser Leu Gly Ile Glu 
            20                  25                  30          


His Ser Ile Pro Leu Val His Gly Ala Gln Gly Cys Ser Ala Phe Ala 
        35                  40                  45              


Lys Val Phe Phe Ile Gln His Phe His Asp Pro Val Pro Leu Gln Ser 
    50                  55                  60                  


Thr Ala Met Asp Pro Thr Ser Thr Ile Met Gly Ala Asp Gly Asn Ile 
65                  70                  75                  80  


Phe Thr Ala Leu Asp Thr Leu Cys Gln Arg Asn Asn Pro Gln Ala Ile 
                85                  90                  95      


Val Leu Leu Ser Thr Gly Leu Ser Glu Ala Gln Gly Ser Asp Ile Ser 
            100                 105                 110         


Arg Val Val Arg Gln Phe Arg Glu Glu Tyr Pro Arg His Lys Gly Val 
        115                 120                 125             


Ala Ile Leu Thr Val Asn Thr Pro Asp Phe Tyr Gly Ser Met Glu Asn 
    130                 135                 140                 


Gly Phe Ser Ala Val Leu Glu Ser Val Ile Glu Gln Trp Val Pro Pro 
145                 150                 155                 160 


Ala Pro Arg Pro Ala Gln Arg Asn Arg Arg Val Asn Leu Leu Val Ser 
                165                 170                 175     


His Leu Cys Ser Pro Gly Asp Ile Glu Trp Leu Arg Arg Cys Val Glu 
            180                 185                 190         


Ala Phe Gly Leu Gln Pro Ile Ile Leu Pro Asp Leu Ala Gln Ser Met 
        195                 200                 205             


Asp Gly His Leu Ala Gln Gly Asp Phe Ser Pro Leu Thr Gln Gly Gly 
    210                 215                 220                 


Thr Pro Leu Arg Gln Ile Glu Gln Met Gly Gln Ser Leu Cys Ser Phe 
225                 230                 235                 240 


Ala Ile Gly Val Ser Leu His Arg Ala Ser Ser Leu Leu Ala Pro Arg 
                245                 250                 255     


Cys Arg Gly Glu Val Ile Ala Leu Pro His Leu Met Thr Leu Glu Arg 
            260                 265                 270         


Cys Asp Ala Phe Ile His Gln Leu Ala Lys Ile Ser Gly Arg Ala Val 
        275                 280                 285             


Pro Glu Trp Leu Glu Arg Gln Arg Gly Gln Leu Gln Asp Ala Met Ile 
    290                 295                 300                 


Asp Cys His Met Trp Leu Gln Gly Gln Arg Met Ala Ile Ala Ala Glu 
305                 310                 315                 320 


Gly Asp Leu Leu Ala Ala Trp Cys Asp Phe Ala Asn Ser Gln Gly Met 
                325                 330                 335     


Gln Pro Gly Pro Leu Val Ala Pro Thr Gly His Pro Ser Leu Arg Gln 
            340                 345                 350         


Leu Pro Val Glu Arg Val Val Pro Gly Asp Leu Glu Asp Leu Gln Thr 
        355                 360                 365             


Leu Leu Cys Ala His Pro Ala Asp Leu Leu Val Ala Asn Ser His Ala 
    370                 375                 380                 


Arg Asp Leu Ala Glu Gln Phe Ala Leu Pro Leu Val Arg Ala Gly Phe 
385                 390                 395                 400 


Pro Leu Phe Asp Lys Leu Gly Glu Phe Arg Arg Val Arg Gln Gly Tyr 
                405                 410                 415     


Ser Gly Met Arg Asp Thr Leu Phe Glu Leu Ala Asn Leu Ile Arg Glu 
            420                 425                 430         


Arg His His His Leu Ala His Tyr Arg Ser Pro Leu Arg Gln Asn Pro 
        435                 440                 445             


Glu Ser Ser Leu Ser Thr Gly Gly Ala Tyr Ala Ala Asp 
    450                 455                 460     


<210>  12
<211>  167
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  12

Met Pro Pro Leu Asp Trp Leu Arg Arg Leu Trp Leu Leu Tyr His Ala 
1               5                   10                  15      


Gly Lys Gly Ser Phe Pro Leu Arg Met Gly Leu Ser Pro Arg Asp Trp 
            20                  25                  30          


Gln Ala Leu Arg Arg Arg Leu Gly Glu Val Glu Thr Pro Leu Asp Gly 
        35                  40                  45              


Glu Thr Leu Thr Arg Arg Arg Leu Met Ala Glu Leu Asn Ala Thr Arg 
    50                  55                  60                  


Glu Glu Glu Arg Gln Gln Leu Gly Ala Trp Leu Ala Gly Trp Met Gln 
65                  70                  75                  80  


Gln Asp Ala Gly Pro Met Ala Gln Ile Ile Ala Glu Val Ser Leu Ala 
                85                  90                  95      


Phe Asn His Leu Trp Gln Asp Leu Gly Leu Ala Ser Arg Ala Glu Leu 
            100                 105                 110         


Arg Leu Leu Met Ser Asp Cys Phe Pro Gln Leu Val Val Met Asn Glu 
        115                 120                 125             


His Asn Met Arg Trp Lys Lys Phe Phe Tyr Arg Gln Arg Cys Leu Leu 
    130                 135                 140                 


Gln Gln Gly Glu Val Ile Cys Arg Ser Pro Ser Cys Asp Glu Cys Trp 
145                 150                 155                 160 


Glu Arg Ser Ala Cys Phe Glu 
                165         


<210>  13
<211>  400
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  13

Met Lys Gln Val Tyr Leu Asp Asn Asn Ala Thr Thr Arg Leu Asp Pro 
1               5                   10                  15      


Met Val Leu Glu Ala Met Met Pro Phe Leu Thr Asp Phe Tyr Gly Asn 
            20                  25                  30          


Pro Ser Ser Ile His Asp Phe Gly Ile Pro Ala Gln Ala Ala Leu Glu 
        35                  40                  45              


Arg Ala His Gln Gln Ala Ala Ala Leu Leu Gly Ala Glu Tyr Pro Ser 
    50                  55                  60                  


Glu Ile Ile Phe Thr Ser Cys Ala Thr Glu Ala Thr Ala Thr Ala Ile 
65                  70                  75                  80  


Ala Ser Ala Ile Ala Leu Leu Pro Glu Arg Arg Glu Ile Ile Thr Ser 
                85                  90                  95      


Val Val Glu His Pro Ala Thr Leu Ala Ala Cys Glu His Met Glu Arg 
            100                 105                 110         


Glu Gly Tyr Arg Ile His Arg Ile Ala Val Asp Gly Glu Gly Ala Leu 
        115                 120                 125             


Asp Met Ala Gln Phe Arg Ala Ala Leu Ser Pro Arg Val Ala Leu Val 
    130                 135                 140                 


Ser Val Met Trp Ala Asn Asn Glu Thr Gly Val Leu Phe Pro Ile Gly 
145                 150                 155                 160 


Glu Met Ala Glu Leu Ala His Glu Gln Gly Ala Leu Phe His Cys Asp 
                165                 170                 175     


Ala Val Gln Val Val Gly Lys Ile Pro Ile Ala Val Gly Gln Thr Arg 
            180                 185                 190         


Ile Asp Met Leu Ser Cys Ser Ala His Lys Phe His Gly Pro Lys Gly 
        195                 200                 205             


Val Gly Cys Leu Tyr Leu Arg Arg Gly Thr Arg Phe Arg Pro Leu Leu 
    210                 215                 220                 


Arg Gly Gly His Gln Glu Tyr Gly Arg Arg Ala Gly Thr Glu Asn Ile 
225                 230                 235                 240 


Cys Gly Ile Val Gly Met Gly Ala Ala Cys Glu Leu Ala Asn Ile His 
                245                 250                 255     


Leu Pro Gly Met Thr His Ile Gly Gln Leu Arg Asn Arg Leu Glu His 
            260                 265                 270         


Arg Leu Leu Ala Ser Val Pro Ser Val Met Val Met Gly Gly Gly Gln 
        275                 280                 285             


Pro Ala Val Pro Gly Thr Val Asn Leu Ala Phe Glu Phe Ile Glu Gly 
    290                 295                 300                 


Glu Ala Ile Leu Leu Leu Leu Asn Gln Ala Gly Ile Ala Ala Ser Ser 
305                 310                 315                 320 


Gly Ser Ala Cys Thr Ser Gly Ser Leu Glu Pro Ser His Val Met Arg 
                325                 330                 335     


Ala Met Asn Ile Pro Tyr Thr Ala Ala His Gly Thr Ile Arg Phe Ser 
            340                 345                 350         


Leu Ser Arg Tyr Thr Arg Glu Lys Glu Ile Asp Tyr Val Val Ala Thr 
        355                 360                 365             


Leu Pro Pro Ile Ile Asp Arg Leu Arg Ala Leu Ser Pro Tyr Trp Gln 
    370                 375                 380                 


Asn Gly Lys Pro Arg Pro Ala Asp Ala Val Phe Thr Pro Val Tyr Gly 
385                 390                 395                 400 


<210>  14
<211>  274
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  14

Met Trp Asn Tyr Ser Glu Lys Val Lys Asp His Phe Phe Asn Pro Arg 
1               5                   10                  15      


Asn Ala Arg Val Val Asp Asn Ala Asn Ala Val Gly Asp Val Gly Ser 
            20                  25                  30          


Leu Ser Cys Gly Asp Ala Leu Arg Leu Met Leu Arg Val Asp Pro Gln 
        35                  40                  45              


Ser Glu Ile Ile Glu Glu Ala Gly Phe Gln Thr Phe Gly Cys Gly Ser 
    50                  55                  60                  


Ala Ile Ala Ser Ser Ser Ala Leu Thr Glu Leu Ile Ile Gly His Thr 
65                  70                  75                  80  


Leu Ala Glu Ala Gly Gln Ile Thr Asn Gln Gln Ile Ala Asp Tyr Leu 
                85                  90                  95      


Asp Gly Leu Pro Pro Glu Lys Met His Cys Ser Val Met Gly Gln Glu 
            100                 105                 110         


Ala Leu Arg Ala Ala Ile Ala Asn Phe Arg Gly Glu Ser Leu Glu Glu 
        115                 120                 125             


Glu His Asp Glu Gly Lys Leu Ile Cys Lys Cys Phe Gly Val Asp Glu 
    130                 135                 140                 


Gly His Ile Arg Arg Ala Val Gln Asn Asn Gly Leu Thr Thr Leu Ala 
145                 150                 155                 160 


Glu Val Ile Asn Tyr Thr Lys Ala Gly Gly Gly Cys Thr Ser Cys His 
                165                 170                 175     


Glu Lys Ile Glu Leu Ala Leu Ala Glu Ile Leu Ala Gln Gln Pro Gln 
            180                 185                 190         


Thr Thr Pro Ala Val Ala Ser Gly Lys Asp Pro His Trp Gln Ser Val 
        195                 200                 205             


Val Asp Thr Ile Ala Glu Leu Arg Pro His Ile Gln Ala Asp Gly Gly 
    210                 215                 220                 


Asp Met Ala Leu Leu Ser Val Thr Asn His Gln Val Thr Val Ser Leu 
225                 230                 235                 240 


Ser Gly Ser Cys Ser Gly Cys Met Met Thr Asp Met Thr Leu Ala Trp 
                245                 250                 255     


Leu Gln Gln Lys Leu Met Glu Arg Thr Gly Cys Tyr Met Glu Val Val 
            260                 265                 270         


Ala Ala 
        


<210>  15
<211>  156
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  15

Met Pro Pro Ile Asn Arg Gln Phe Asp Met Val His Ser Asp Glu Trp 
1               5                   10                  15      


Ser Met Lys Val Ala Phe Ala Ser Ser Asp Tyr Arg His Val Asp Gln 
            20                  25                  30          


His Phe Gly Ala Thr Pro Arg Leu Val Val Tyr Gly Val Lys Ala Asp 
        35                  40                  45              


Arg Val Thr Leu Ile Arg Val Val Asp Phe Ser Val Glu Asn Gly His 
    50                  55                  60                  


Gln Thr Glu Lys Ile Ala Arg Arg Ile His Ala Leu Glu Asp Cys Val 
65                  70                  75                  80  


Thr Leu Phe Cys Val Ala Ile Gly Asp Ala Val Phe Arg Gln Leu Leu 
                85                  90                  95      


Gln Val Gly Val Arg Ala Glu Arg Val Pro Ala Asp Thr Thr Ile Val 
            100                 105                 110         


Gly Leu Leu Gln Glu Ile Gln Leu Tyr Trp Tyr Asp Lys Gly Gln Arg 
        115                 120                 125             


Lys Asn Gln Arg Gln Arg Asp Pro Glu Arg Phe Thr Arg Leu Leu Gln 
    130                 135                 140                 


Glu Gln Glu Trp His Gly Asp Pro Asp Pro Arg Arg 
145                 150                 155     


<210>  16
<211>  176
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  16

Met Ala Asn Ile Gly Ile Phe Phe Gly Thr Asp Thr Gly Lys Thr Arg 
1               5                   10                  15      


Lys Ile Ala Lys Met Ile His Lys Gln Leu Gly Glu Leu Ala Asp Ala 
            20                  25                  30          


Pro Val Asn Ile Asn Arg Thr Thr Leu Asp Asp Phe Met Ala Tyr Pro 
        35                  40                  45              


Val Leu Leu Leu Gly Thr Pro Thr Leu Gly Asp Gly Gln Leu Pro Gly 
    50                  55                  60                  


Leu Glu Ala Gly Cys Glu Ser Glu Ser Trp Ser Glu Phe Ile Ser Gly 
65                  70                  75                  80  


Leu Asp Asp Ala Ser Leu Lys Gly Lys Thr Val Ala Leu Phe Gly Leu 
                85                  90                  95      


Gly Asp Gln Arg Gly Tyr Pro Asp Asn Phe Val Ser Gly Met Arg Pro 
            100                 105                 110         


Leu Phe Asp Ala Leu Ser Ala Arg Gly Ala Gln Met Ile Gly Ser Trp 
        115                 120                 125             


Pro Asn Glu Gly Tyr Glu Phe Ser Ala Ser Ser Ala Leu Glu Gly Asp 
    130                 135                 140                 


Arg Phe Val Gly Leu Val Leu Asp Gln Asp Asn Gln Phe Asp Gln Thr 
145                 150                 155                 160 


Glu Ala Arg Leu Ala Ser Trp Leu Glu Glu Ile Lys Arg Thr Val Leu 
                165                 170                 175     


<210>  17
<211>  148
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  17

Met Arg Pro Lys Phe Thr Phe Ser Glu Glu Val Arg Val Val Arg Ala 
1               5                   10                  15      


Ile Arg Asn Asp Gly Thr Val Ala Gly Phe Ala Pro Gly Ala Leu Leu 
            20                  25                  30          


Val Arg Arg Gly Ser Thr Gly Phe Val Arg Asp Trp Gly Val Phe Leu 
        35                  40                  45              


Gln Asp Gln Ile Ile Tyr Gln Ile His Phe Pro Glu Thr Asp Arg Ile 
    50                  55                  60                  


Ile Gly Cys Arg Glu Gln Glu Leu Ile Pro Ile Thr Gln Pro Trp Leu 
65                  70                  75                  80  


Ala Gly Asn Leu Gln Tyr Arg Asp Ser Val Thr Cys Gln Met Ala Leu 
                85                  90                  95      


Ala Val Asn Gly Asp Val Val Val Ser Ala Gly Gln Arg Gly Arg Val 
            100                 105                 110         


Glu Ala Thr Asp Arg Gly Glu Leu Gly Asp Ser Tyr Thr Val Asp Phe 
        115                 120                 125             


Ser Gly Arg Trp Phe Arg Val Pro Val Gln Ala Ile Ala Leu Ile Glu 
    130                 135                 140                 


Glu Arg Glu Glu 
145             


<210>  18
<211>  1171
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  18

Met Ser Gly Lys Met Lys Thr Met Asp Gly Asn Ala Ala Ala Ala Trp 
1               5                   10                  15      


Ile Ser Tyr Ala Phe Thr Glu Val Ala Ala Ile Tyr Pro Ile Thr Pro 
            20                  25                  30          


Ser Thr Pro Met Ala Glu Asn Val Asp Glu Trp Ala Ala Gln Gly Lys 
        35                  40                  45              


Lys Asn Leu Phe Gly Gln Pro Val Arg Leu Met Glu Met Gln Ser Glu 
    50                  55                  60                  


Ala Gly Ala Ala Gly Ala Val His Gly Ala Leu Gln Ala Gly Ala Leu 
65                  70                  75                  80  


Thr Thr Thr Tyr Thr Ala Ser Gln Gly Leu Leu Leu Met Ile Pro Asn 
                85                  90                  95      


Met Tyr Lys Ile Ala Gly Glu Leu Leu Pro Gly Val Phe His Val Ser 
            100                 105                 110         


Ala Arg Ala Leu Ala Thr Asn Ser Leu Asn Ile Phe Gly Asp His Gln 
        115                 120                 125             


Asp Val Met Ala Val Arg Gln Thr Gly Cys Ala Met Leu Ala Glu Asn 
    130                 135                 140                 


Asn Val Gln Gln Val Met Asp Leu Ser Ala Val Ala His Leu Ala Ala 
145                 150                 155                 160 


Ile Lys Gly Arg Ile Pro Phe Val Asn Phe Phe Asp Gly Phe Arg Thr 
                165                 170                 175     


Ser His Glu Ile Gln Lys Ile Glu Val Leu Glu Tyr Glu Gln Leu Ala 
            180                 185                 190         


Thr Leu Leu Asp Arg Pro Ala Leu Asp Ser Phe Arg Arg Asn Ala Leu 
        195                 200                 205             


His Pro Asp His Pro Val Ile Arg Gly Thr Ala Gln Asn Pro Asp Ile 
    210                 215                 220                 


Tyr Phe Gln Glu Arg Glu Ala Gly Asn Arg Phe Tyr Gln Ala Leu Pro 
225                 230                 235                 240 


Asp Ile Val Glu Ser Tyr Met Thr Gln Ile Ser Ala Leu Thr Gly Arg 
                245                 250                 255     


Glu Tyr His Leu Phe Asn Tyr Thr Gly Ala Ala Asp Ala Glu Arg Val 
            260                 265                 270         


Ile Ile Ala Met Gly Ser Val Cys Asp Thr Val Gln Glu Val Val Asp 
        275                 280                 285             


Thr Leu Asn Ala Ala Gly Glu Lys Val Gly Leu Leu Ser Val His Leu 
    290                 295                 300                 


Phe Arg Pro Phe Ser Leu Ala His Phe Phe Ala Gln Leu Pro Lys Thr 
305                 310                 315                 320 


Val Gln Arg Ile Ala Val Leu Asp Arg Thr Lys Glu Pro Gly Ala Gln 
                325                 330                 335     


Ala Glu Pro Leu Cys Leu Asp Val Lys Asn Ala Phe Tyr His His Asp 
            340                 345                 350         


Asp Ala Pro Leu Ile Val Gly Gly Arg Tyr Ala Leu Gly Gly Lys Asp 
        355                 360                 365             


Val Leu Pro Asn Asp Ile Ala Ala Val Phe Asp Asn Leu Asn Lys Pro 
    370                 375                 380                 


Leu Pro Met Asp Gly Phe Thr Leu Gly Ile Val Asp Asp Val Thr Phe 
385                 390                 395                 400 


Thr Ser Leu Pro Pro Arg Gln Gln Thr Leu Ala Val Ser His Asp Gly 
                405                 410                 415     


Ile Thr Ala Cys Lys Phe Trp Gly Met Gly Ser Asp Gly Thr Val Gly 
            420                 425                 430         


Ala Asn Lys Ser Ala Ile Lys Ile Ile Gly Asp Lys Thr Pro Leu Tyr 
        435                 440                 445             


Ala Gln Ala Tyr Phe Ser Tyr Asp Ser Lys Lys Ser Gly Gly Ile Thr 
    450                 455                 460                 


Val Ser His Leu Arg Phe Gly Asp Arg Pro Ile Asn Ser Pro Tyr Leu 
465                 470                 475                 480 


Ile His Arg Ala Asp Phe Ile Ser Cys Ser Gln Gln Ser Tyr Val Glu 
                485                 490                 495     


Arg Tyr Asp Leu Leu Asp Gly Leu Lys Pro Gly Gly Thr Phe Leu Leu 
            500                 505                 510         


Asn Cys Ser Trp Ser Asp Ala Glu Leu Glu Gln His Leu Pro Val Gly 
        515                 520                 525             


Phe Lys Arg Tyr Leu Ala Arg Glu Asn Ile His Phe Tyr Thr Leu Asn 
    530                 535                 540                 


Ala Val Asp Ile Ala Arg Glu Leu Gly Leu Gly Gly Arg Phe Asn Met 
545                 550                 555                 560 


Leu Met Gln Ala Ala Phe Phe Lys Leu Ala Ala Ile Ile Asp Pro Gln 
                565                 570                 575     


Thr Ala Ala Asp Tyr Leu Lys Gln Ala Val Glu Lys Ser Tyr Gly Ser 
            580                 585                 590         


Lys Gly Ala Ala Val Ile Glu Met Asn Gln Arg Ala Ile Glu Leu Gly 
        595                 600                 605             


Met Ala Ser Leu His Gln Val Thr Ile Pro Ala His Trp Ala Thr Leu 
    610                 615                 620                 


Asp Glu Pro Ala Ala Gln Ala Ser Ala Met Met Pro Asp Phe Ile Arg 
625                 630                 635                 640 


Asp Ile Leu Gln Pro Met Asn Arg Gln Cys Gly Asp Gln Leu Pro Val 
                645                 650                 655     


Ser Ala Phe Val Gly Met Glu Asp Gly Thr Phe Pro Ser Gly Thr Ala 
            660                 665                 670         


Ala Trp Glu Lys Arg Gly Ile Ala Leu Glu Val Pro Val Trp Gln Pro 
        675                 680                 685             


Glu Gly Cys Thr Gln Cys Asn Gln Cys Ala Phe Ile Cys Pro His Ala 
    690                 695                 700                 


Ala Ile Arg Pro Ala Leu Leu Asn Gly Glu Glu His Asp Ala Ala Pro 
705                 710                 715                 720 


Val Gly Leu Leu Ser Lys Pro Ala Gln Gly Ala Lys Glu Tyr His Tyr 
                725                 730                 735     


His Leu Ala Ile Ser Pro Leu Asp Cys Ser Gly Cys Gly Asn Cys Val 
            740                 745                 750         


Asp Ile Cys Pro Ala Arg Gly Lys Ala Leu Lys Met Gln Ser Leu Asp 
        755                 760                 765             


Ser Gln Arg Gln Met Ala Pro Val Trp Asp Tyr Ala Leu Ala Leu Thr 
    770                 775                 780                 


Pro Lys Ser Asn Pro Phe Arg Lys Thr Thr Val Lys Gly Ser Gln Phe 
785                 790                 795                 800 


Glu Thr Pro Leu Leu Glu Phe Ser Gly Ala Cys Ala Gly Cys Gly Glu 
                805                 810                 815     


Thr Pro Tyr Ala Arg Leu Ile Thr Gln Leu Phe Gly Asp Arg Met Leu 
            820                 825                 830         


Ile Ala Asn Ala Thr Gly Cys Ser Ser Ile Trp Gly Ala Ser Ala Pro 
        835                 840                 845             


Ser Ile Pro Tyr Thr Thr Asn His Arg Gly His Gly Pro Ala Trp Ala 
    850                 855                 860                 


Asn Ser Leu Phe Glu Asp Asn Ala Glu Phe Gly Leu Gly Met Met Leu 
865                 870                 875                 880 


Gly Gly Gln Ala Val Arg Gln Gln Ile Ala Asp Asp Met Thr Ala Ala 
                885                 890                 895     


Leu Ala Leu Pro Val Ser Asp Glu Leu Ser Asp Ala Met Arg Gln Trp 
            900                 905                 910         


Leu Ala Lys Gln Asp Glu Gly Glu Gly Thr Arg Glu Arg Ala Asp Arg 
        915                 920                 925             


Leu Ser Glu Arg Leu Ala Ala Glu Lys Glu Gly Val Pro Leu Leu Glu 
    930                 935                 940                 


Gln Leu Trp Gln Asn Arg Asp Tyr Phe Val Arg Arg Ser Gln Trp Ile 
945                 950                 955                 960 


Phe Gly Gly Asp Gly Trp Ala Tyr Asp Ile Gly Phe Gly Gly Leu Asp 
                965                 970                 975     


His Val Leu Ala Ser Gly Glu Asp Val Asn Ile Leu Val Phe Asp Thr 
            980                 985                 990         


Glu Val Tyr Ser Asn Thr Gly Gly  Gln Ser Ser Lys Ser  Thr Pro Val 
        995                 1000                 1005             


Ala Ala  Ile Ala Lys Phe Ala  Ala Gln Gly Lys Arg  Thr Arg Lys 
    1010                 1015                 1020             


Lys Asp  Leu Gly Met Met Ala  Met Ser Tyr Gly Asn  Val Tyr Val 
    1025                 1030                 1035             


Ala Gln  Val Ala Met Gly Ala  Asp Lys Asp Gln Thr  Leu Arg Ala 
    1040                 1045                 1050             


Ile Ala  Glu Ala Glu Ala Trp  Pro Gly Pro Ser Leu  Val Ile Ala 
    1055                 1060                 1065             


Tyr Ala  Ala Cys Ile Asn His  Gly Leu Lys Ala Gly  Met Arg Cys 
    1070                 1075                 1080             


Ser Gln  Arg Glu Ala Lys Arg  Ala Val Glu Ala Gly  Tyr Trp His 
    1085                 1090                 1095             


Leu Trp  Arg Tyr His Pro Gln  Arg Glu Ala Glu Gly  Lys Thr Pro 
    1100                 1105                 1110             


Phe Met  Leu Asp Ser Glu Glu  Pro Glu Glu Ser Phe  Arg Asp Phe 
    1115                 1120                 1125             


Leu Leu  Gly Glu Val Arg Tyr  Ala Ser Leu His Lys  Thr Thr Pro 
    1130                 1135                 1140             


His Leu  Ala Asp Ala Leu Phe  Ser Arg Thr Glu Glu  Asp Ala Arg 
    1145                 1150                 1155             


Ala Arg  Phe Ala Gln Tyr Arg  Arg Leu Ala Gly Glu  Glu 
    1160                 1165                 1170     


<210>  19
<211>  266
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  19

Met Asn Pro Trp Gln Arg Phe Ala Arg Gln Arg Leu Ala Arg Ser Arg 
1               5                   10                  15      


Trp Asn Arg Asp Pro Ala Ala Leu Asp Pro Ala Asp Thr Pro Ala Phe 
            20                  25                  30          


Glu Gln Ala Trp Gln Arg Gln Cys His Met Glu Gln Thr Ile Val Ala 
        35                  40                  45              


Arg Val Pro Glu Gly Asp Ile Pro Ala Ala Leu Leu Glu Asn Ile Ala 
    50                  55                  60                  


Ala Ser Leu Ala Ile Trp Leu Asp Glu Gly Asp Phe Ala Pro Pro Glu 
65                  70                  75                  80  


Arg Ala Ala Ile Val Arg His His Ala Arg Leu Glu Leu Ala Phe Ala 
                85                  90                  95      


Asp Ile Ala Arg Gln Ala Pro Gln Pro Asp Leu Ser Thr Val Gln Ala 
            100                 105                 110         


Trp Tyr Leu Arg His Gln Thr Gln Phe Met Arg Pro Glu Gln Arg Leu 
        115                 120                 125             


Thr Arg His Leu Leu Leu Thr Val Asp Asn Asp Arg Glu Ala Val His 
    130                 135                 140                 


Gln Arg Ile Leu Gly Leu Tyr Arg Gln Ile Asn Ala Ser Arg Asp Ala 
145                 150                 155                 160 


Phe Ala Pro Leu Ala Gln Arg His Ser His Cys Pro Ser Ala Leu Glu 
                165                 170                 175     


Glu Gly Arg Leu Gly Trp Ile Ser Arg Gly Leu Leu Tyr Pro Gln Leu 
            180                 185                 190         


Glu Thr Ala Leu Phe Ser Leu Ala Glu Asn Ala Leu Ser Leu Pro Ile 
        195                 200                 205             


Ala Ser Glu Leu Gly Trp His Leu Leu Trp Cys Glu Ala Ile Arg Pro 
    210                 215                 220                 


Ala Ala Pro Met Glu Pro Gln Gln Ala Leu Glu Ser Ala Arg Asp Tyr 
225                 230                 235                 240 


Leu Trp Gln Gln Ser Gln Gln Arg His Gln Arg Gln Trp Leu Glu Gln 
                245                 250                 255     


Met Ile Ser Arg Gln Pro Gly Leu Cys Gly 
            260                 265     


<210>  20
<211>  381
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  20

Met Glu Arg Val Leu Ile Asn Asp Thr Thr Leu Arg Asp Gly Glu Gln 
1               5                   10                  15      


Ser Pro Gly Val Ala Phe Arg Thr Ser Glu Lys Val Ala Ile Ala Glu 
            20                  25                  30          


Ala Leu Tyr Ala Ala Gly Ile Thr Ala Met Glu Val Gly Thr Pro Ala 
        35                  40                  45              


Met Gly Asp Glu Glu Ile Ala Arg Ile Gln Leu Val Arg Arg Gln Leu 
    50                  55                  60                  


Pro Asp Ala Thr Leu Met Thr Trp Cys Arg Met Asn Ala Leu Glu Ile 
65                  70                  75                  80  


Arg Gln Ser Ala Asp Leu Gly Ile Asp Trp Val Asp Ile Ser Ile Pro 
                85                  90                  95      


Ala Ser Asp Lys Leu Arg Gln Tyr Lys Leu Arg Glu Pro Leu Ala Val 
            100                 105                 110         


Leu Leu Glu Arg Leu Ala Met Phe Ile His Leu Ala His Thr Leu Gly 
        115                 120                 125             


Leu Lys Val Cys Ile Gly Cys Glu Asp Ala Ser Arg Ala Ser Gly Gln 
    130                 135                 140                 


Thr Leu Arg Ala Ile Ala Glu Val Ala Gln Asn Ala Pro Ala Ala Arg 
145                 150                 155                 160 


Leu Arg Tyr Ala Asp Thr Val Gly Leu Leu Asp Pro Phe Thr Thr Ala 
                165                 170                 175     


Ala Gln Ile Ser Ala Leu Arg Asp Val Trp Ser Gly Glu Ile Glu Met 
            180                 185                 190         


His Ala His Asn Asp Leu Gly Met Ala Thr Ala Asn Thr Leu Ala Ala 
        195                 200                 205             


Val Ser Ala Gly Ala Thr Ser Val Asn Thr Thr Val Leu Gly Leu Gly 
    210                 215                 220                 


Glu Arg Ala Gly Asn Ala Ala Ala Trp Lys Pro Ser Ala Leu Gly Leu 
225                 230                 235                 240 


Glu Arg Cys Leu Gly Val Glu Thr Gly Val His Phe Ser Ala Leu Pro 
                245                 250                 255     


Ala Leu Cys Gln Arg Val Ala Glu Ala Ala Gln Arg Ala Ile Asp Pro 
            260                 265                 270         


Gln Gln Pro Leu Val Gly Glu Leu Val Phe Thr His Glu Ser Gly Val 
        275                 280                 285             


His Val Ala Ala Leu Leu Arg Asp Ser Glu Ser Tyr Gln Ser Ile Ala 
    290                 295                 300                 


Pro Ser Leu Met Gly Arg Ser Tyr Arg Leu Val Leu Gly Lys His Ser 
305                 310                 315                 320 


Gly Arg Gln Ala Val Asn Gly Val Phe Asp Gln Met Gly Tyr His Leu 
                325                 330                 335     


Asn Ala Ala Gln Ile Asn Gln Leu Leu Pro Ala Ile Arg Arg Phe Ala 
            340                 345                 350         


Glu Asn Trp Lys Arg Ser Pro Lys Asp Tyr Glu Leu Val Ala Ile Tyr 
        355                 360                 365             


Asp Glu Leu Cys Gly Glu Ser Ala Leu Arg Ala Arg Gly 
    370                 375                 380     


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  21

Ala Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  22

Ala Gly Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
1               5                   10          


<210>  23
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  23

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Thr Met Arg Gln Cys Ala Ile Tyr Gly Lys Gly Gly Ile Gly 
        35                  40                  45              


Lys Ser Thr Thr Thr Gln Asn Leu Val Ala Ala Leu Ala Glu Met Gly 
    50                  55                  60                  


Lys Lys Val Met Ile Val Gly Cys Asp Pro Lys Ala Asp Ser Thr Arg 
65                  70                  75                  80  


Leu Ile Leu His Ala Lys Ala Gln Asn Thr Ile Met Glu Met Ala Ala 
                85                  90                  95      


Glu Val Gly Ser Val Glu Asp Leu Glu Leu Glu Asp Val Leu Gln Ile 
            100                 105                 110         


Gly Tyr Gly Asp Val Arg Cys Ala Glu Ser Gly Gly Pro Glu Pro Gly 
        115                 120                 125             


Val Gly Cys Ala Gly Arg Gly Val Ile Thr Ala Ile Asn Phe Leu Glu 
    130                 135                 140                 


Glu Glu Gly Ala Tyr Glu Asp Asp Leu Asp Phe Val Phe Tyr Asp Val 
145                 150                 155                 160 


Leu Gly Asp Val Val Cys Gly Gly Phe Ala Met Pro Ile Arg Glu Asn 
                165                 170                 175     


Lys Ala Gln Glu Ile Tyr Ile Val Cys Ser Gly Glu Met Met Ala Met 
            180                 185                 190         


Tyr Ala Ala Asn Asn Ile Ser Lys Gly Ile Val Lys Tyr Ala Lys Ser 
        195                 200                 205             


Gly Lys Val Arg Leu Gly Gly Leu Ile Cys Asn Ser Arg Gln Thr Asp 
    210                 215                 220                 


Arg Glu Asp Glu Leu Ile Ile Ala Leu Ala Glu Lys Leu Gly Thr Gln 
225                 230                 235                 240 


Met Ile His Phe Val Pro Arg Asp Asn Ile Val Gln Arg Ala Glu Ile 
                245                 250                 255     


Arg Arg Met Thr Val Ile Glu Tyr Asp Pro Ala Cys Lys Gln Ala Asn 
            260                 265                 270         


Glu Tyr Arg Thr Leu Ala Gln Lys Ile Val Asn Asn Thr Met Lys Val 
        275                 280                 285             


Val Pro Thr Pro Cys Thr Met Asp Glu Leu Glu Ser Leu Leu Met Glu 
    290                 295                 300                 


Phe Gly Ile Met Glu Glu Glu Asp Thr Ser Ile Ile Gly Lys Thr Ala 
305                 310                 315                 320 


Ala Glu Glu Asn Ala Ala Ala Gly Gly Gly Gly Gly Tyr Pro Tyr Asp 
                325                 330                 335     


Val Pro Asp Tyr Ala Pro Gly 
            340             


<210>  24
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  24

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Thr Asn Ala Thr Gly Glu Arg Asn Leu Ala Leu Ile Gln Glu 
        35                  40                  45              


Val Leu Glu Val Phe Pro Glu Thr Ala Arg Lys Glu Arg Arg Lys His 
    50                  55                  60                  


Met Met Val Ser Asp Pro Lys Met Lys Ser Val Gly Lys Cys Ile Ile 
65                  70                  75                  80  


Ser Asn Arg Lys Ser Gln Pro Gly Val Met Thr Val Arg Gly Cys Ala 
                85                  90                  95      


Tyr Ala Gly Ser Lys Gly Val Val Phe Gly Pro Ile Lys Asp Met Ala 
            100                 105                 110         


His Ile Ser His Gly Pro Ala Gly Cys Gly Gln Tyr Ser Arg Ala Glu 
        115                 120                 125             


Arg Arg Asn Tyr Tyr Thr Gly Val Ser Gly Val Asp Ser Phe Gly Thr 
    130                 135                 140                 


Leu Asn Phe Thr Ser Asp Phe Gln Glu Arg Asp Ile Val Phe Gly Gly 
145                 150                 155                 160 


Asp Lys Lys Leu Ser Lys Leu Ile Glu Glu Met Glu Leu Leu Phe Pro 
                165                 170                 175     


Leu Thr Lys Gly Ile Thr Ile Gln Ser Glu Cys Pro Val Gly Leu Ile 
            180                 185                 190         


Gly Asp Asp Ile Ser Ala Val Ala Asn Ala Ser Ser Lys Ala Leu Asp 
        195                 200                 205             


Lys Pro Val Ile Pro Val Arg Cys Glu Gly Phe Arg Gly Val Ser Gln 
    210                 215                 220                 


Ser Leu Gly His His Ile Ala Asn Asp Val Val Arg Asp Trp Ile Leu 
225                 230                 235                 240 


Asn Asn Arg Glu Gly Gln Pro Phe Glu Thr Thr Pro Tyr Asp Val Ala 
                245                 250                 255     


Ile Ile Gly Asp Tyr Asn Ile Gly Gly Asp Ala Trp Ala Ser Arg Ile 
            260                 265                 270         


Leu Leu Glu Glu Met Gly Leu Arg Val Val Ala Gln Trp Ser Gly Asp 
        275                 280                 285             


Gly Thr Leu Val Glu Met Glu Asn Thr Pro Phe Val Lys Leu Asn Leu 
    290                 295                 300                 


Val His Cys Tyr Arg Ser Met Asn Tyr Ile Ala Arg His Met Glu Glu 
305                 310                 315                 320 


Lys His Gln Ile Pro Trp Met Glu Tyr Asn Phe Phe Gly Pro Thr Lys 
                325                 330                 335     


Ile Ala Glu Ser Leu Arg Lys Ile Ala Asp Gln Phe Asp Asp Thr Ile 
            340                 345                 350         


Arg Ala Asn Ala Glu Ala Val Ile Ala Arg Tyr Glu Gly Gln Met Ala 
        355                 360                 365             


Ala Ile Ile Ala Lys Tyr Arg Pro Arg Leu Glu Gly Arg Lys Val Leu 
    370                 375                 380                 


Leu Tyr Ile Gly Gly Leu Arg Pro Arg His Val Ile Gly Ala Tyr Glu 
385                 390                 395                 400 


Asp Leu Gly Met Glu Ile Ile Ala Ala Gly Tyr Glu Phe Ala His Asn 
                405                 410                 415     


Asp Asp Tyr Asp Arg Thr Leu Pro Asp Leu Lys Glu Gly Thr Leu Leu 
            420                 425                 430         


Phe Asp Asp Ala Ser Ser Tyr Glu Leu Glu Ala Phe Val Lys Ala Leu 
        435                 440                 445             


Lys Pro Asp Leu Ile Gly Ser Gly Ile Lys Glu Lys Tyr Ile Phe Gln 
    450                 455                 460                 


Lys Met Gly Val Pro Phe Arg Gln Met His Ser Trp Asp Tyr Ser Gly 
465                 470                 475                 480 


Pro Tyr His Gly Tyr Asp Gly Phe Ala Ile Phe Ala Arg Asp Met Asp 
                485                 490                 495     


Met Thr Leu Asn Asn Pro Ala Trp Asn Glu Leu Thr Ala Pro Trp Leu 
            500                 505                 510         


Lys Ser Ala Ala Gly Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
        515                 520                 525         


<210>  25
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  25

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Ser Gln Thr Ile Asp Lys Ile Asn Ser Cys Tyr Pro Leu Phe 
        35                  40                  45              


Glu Gln Asp Glu Tyr Gln Glu Leu Phe Arg Asn Lys Arg Gln Leu Glu 
    50                  55                  60                  


Glu Ala His Asp Ala Gln Arg Val Gln Glu Val Phe Ala Trp Thr Thr 
65                  70                  75                  80  


Thr Ala Glu Tyr Glu Ala Leu Asn Phe Arg Arg Glu Ala Leu Thr Val 
                85                  90                  95      


Asp Pro Ala Lys Ala Cys Gln Pro Leu Gly Ala Val Leu Cys Ser Leu 
            100                 105                 110         


Gly Phe Ala Asn Thr Leu Pro Tyr Val His Gly Ser Gln Gly Cys Val 
        115                 120                 125             


Ala Tyr Phe Arg Thr Tyr Phe Asn Arg His Phe Lys Glu Pro Ile Ala 
    130                 135                 140                 


Cys Val Ser Asp Ser Met Thr Glu Asp Ala Ala Val Phe Gly Gly Asn 
145                 150                 155                 160 


Asn Asn Met Asn Leu Gly Leu Gln Asn Ala Ser Ala Leu Tyr Lys Pro 
                165                 170                 175     


Glu Ile Ile Ala Val Ser Thr Thr Cys Met Ala Glu Val Ile Gly Asp 
            180                 185                 190         


Asp Leu Gln Ala Phe Ile Ala Asn Ala Lys Lys Asp Gly Phe Val Asp 
        195                 200                 205             


Ser Ser Ile Ala Val Pro His Ala His Thr Pro Ser Phe Ile Gly Ser 
    210                 215                 220                 


His Val Thr Gly Trp Asp Asn Met Phe Glu Gly Phe Ala Lys Thr Phe 
225                 230                 235                 240 


Thr Ala Asp Tyr Gln Gly Gln Pro Gly Lys Leu Pro Lys Leu Asn Leu 
                245                 250                 255     


Val Thr Gly Phe Glu Thr Tyr Leu Gly Asn Phe Arg Val Leu Lys Arg 
            260                 265                 270         


Met Met Glu Gln Met Ala Val Pro Cys Ser Leu Leu Ser Asp Pro Ser 
        275                 280                 285             


Glu Val Leu Asp Thr Pro Ala Asp Gly His Tyr Arg Met Tyr Ser Gly 
    290                 295                 300                 


Gly Thr Thr Gln Gln Glu Met Lys Glu Ala Pro Asp Ala Ile Asp Thr 
305                 310                 315                 320 


Leu Leu Leu Gln Pro Trp Gln Leu Leu Lys Ser Lys Lys Val Val Gln 
                325                 330                 335     


Glu Met Trp Asn Gln Pro Ala Thr Glu Val Ala Ile Pro Leu Gly Leu 
            340                 345                 350         


Ala Ala Thr Asp Glu Leu Leu Met Thr Val Ser Gln Leu Ser Gly Lys 
        355                 360                 365             


Pro Ile Ala Asp Ala Leu Thr Leu Glu Arg Gly Arg Leu Val Asp Met 
    370                 375                 380                 


Met Leu Asp Ser His Thr Trp Leu His Gly Lys Lys Phe Gly Leu Tyr 
385                 390                 395                 400 


Gly Asp Pro Asp Phe Val Met Gly Leu Thr Arg Phe Leu Leu Glu Leu 
                405                 410                 415     


Gly Cys Glu Pro Thr Val Ile Leu Ser His Asn Ala Asn Lys Arg Trp 
            420                 425                 430         


Gln Lys Ala Met Asn Lys Met Leu Asp Ala Ser Pro Tyr Gly Arg Asp 
        435                 440                 445             


Ser Glu Val Phe Ile Asn Cys Asp Leu Trp His Phe Arg Ser Leu Met 
    450                 455                 460                 


Phe Thr Arg Gln Pro Asp Phe Met Ile Gly Asn Ser Tyr Gly Lys Phe 
465                 470                 475                 480 


Ile Gln Arg Asp Thr Leu Ala Lys Gly Lys Ala Phe Glu Val Pro Leu 
                485                 490                 495     


Ile Arg Leu Gly Phe Pro Leu Phe Asp Arg His His Leu His Arg Gln 
            500                 505                 510         


Thr Thr Trp Gly Tyr Glu Gly Ala Met Asn Ile Val Thr Thr Leu Val 
        515                 520                 525             


Asn Ala Val Leu Glu Lys Leu Asp Ser Asp Thr Ser Gln Leu Gly Lys 
    530                 535                 540                 


Thr Asp Tyr Ser Phe Asp Leu Val Arg Ala Gly Gly Gly Gly Gly Tyr 
545                 550                 555                 560 


Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
                565                 570 


<210>  26
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  26

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Ser Asp Asn Asp Thr Leu Phe Trp Arg Met Leu Ala Leu Phe 
        35                  40                  45              


Gln Ser Leu Pro Asp Leu Gln Pro Ala Gln Ile Val Asp Trp Leu Ala 
    50                  55                  60                  


Gln Glu Ser Gly Glu Thr Leu Thr Pro Glu Arg Leu Ala Thr Leu Thr 
65                  70                  75                  80  


Gln Pro Gln Leu Ala Ala Ser Phe Pro Ser Ala Thr Ala Val Met Ser 
                85                  90                  95      


Pro Ala Arg Trp Ser Arg Val Met Ala Ser Leu Gln Gly Ala Leu Pro 
            100                 105                 110         


Ala His Leu Arg Ile Val Arg Pro Ala Gln Arg Thr Pro Gln Leu Leu 
        115                 120                 125             


Ala Ala Phe Cys Ser Gln Asp Gly Leu Val Ile Asn Gly His Phe Gly 
    130                 135                 140                 


Gln Gly Arg Leu Phe Phe Ile Tyr Ala Phe Asp Glu Gln Gly Gly Trp 
145                 150                 155                 160 


Leu Tyr Asp Leu Arg Arg Tyr Pro Ser Ala Pro His Gln Gln Glu Ala 
                165                 170                 175     


Asn Glu Val Arg Ala Arg Leu Ile Glu Asp Cys Gln Leu Leu Phe Cys 
            180                 185                 190         


Gln Glu Ile Gly Gly Pro Ala Ala Ala Arg Pro Ile Arg His Arg Ile 
        195                 200                 205             


His Pro Met Lys Ala Gln Pro Gly Thr Thr Ile Gln Ala Gln Cys Glu 
    210                 215                 220                 


Ala Ile Asn Thr Leu Leu Ala Gly Arg Leu Pro Pro Trp Leu Ala Lys 
225                 230                 235                 240 


Arg Leu Asn Arg Asp Asn Pro Leu Glu Glu Arg Val Phe Ala Gly Gly 
                245                 250                 255     


Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
            260                 265                 270 


<210>  27
<211>  950
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AscI Fragment

<400>  27
ggcgcgccaa ctatgagaca atgtgctatc tatggaaagg gtggaatcgg aaagtctact       60

actactcaga accttgttgc tgctcttgct gagatgggaa agaaagttat gatcgttgga      120

tgcgatccta aggctgattc tactagactt atcctccatg ctaaggctca gaacaccatt      180

atggaaatgg ctgctgaggt tggatctgtt gaagatcttg agcttgagga tgttctccaa      240

atcggatacg gtgatgttag atgtgctgaa tctggtggac ctgaacctgg tgttggatgt      300

gctggaagag gtgttattac cgctatcaac ttccttgaag aagagggagc ttacgaggat      360

gatctcgatt tcgttttcta cgatgtgctc ggagatgttg tttgtggtgg atttgctatg      420

cctatcagag agaacaaggc tcaagagatc tacatcgttt gctctggtga gatgatggct      480

atgtatgctg ctaacaacat ctctaaggga atcgtgaagt acgctaagtc tggaaaggtt      540

agacttggag gactcatctg taactctaga cagactgata gagaggatga gcttattatc      600

gctttggctg agaagttggg aactcagatg atccatttcg tgccaagaga taacatcgtt      660

cagagagctg agatcagaag gatgactgtt atcgaatacg atcctgcttg caaacaagct      720

aacgagtata gaactctcgc tcagaagatc gttaacaaca ctatgaaggt ggtgcctact      780

ccttgtacta tggatgaact tgagtctctc ctcatggaat ttggaatcat ggaagaagag      840

gatacctcta tcatcggaaa gactgctgct gaagaaaacg ctgctgccgg cggtggaggt      900

ggataccctt acgacgttcc tgattacgct cccgggtgat gaggcgcgcc                 950


<210>  28
<211>  1502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AscI fragment

<400>  28
ggcgcgccaa ctaatgctac tggtgaaaga aacctcgctc tcatccaaga ggttttggaa       60

gtttttcctg agactgctag gaaagaaagg cgtaagcaca tgatggtgtc tgatcctaag      120

atgaagtctg tgggaaagtg catcatctct aacagaaagt ctcagcctgg tgtgatgact      180

gttagaggat gtgcttatgc tggatctaag ggtgttgttt tcggacctat caaggatatg      240

gctcatatct ctcatggacc tgctggatgt ggacaatatt ctagagctga gcgtaggaac      300

tactacactg gtgtttctgg tgtggattct ttcggaactc tcaacttcac ctctgatttc      360

caagagcgtg atatcgtttt cggaggtgat aagaagctct ctaagttgat cgaagagatg      420

gaactcttgt tcccactcac taagggaatc actatccaat ctgagtgccc tgttggactt      480

atcggagatg atatttctgc tgtggctaac gcttcttcta aggctcttga taagcctgtt      540

atccctgtta gatgtgaagg attcagggga gtttctcagt ctcttggaca tcatatcgct      600

aacgatgtgg tgagagattg gatccttaac aacagagagg gacaaccttt cgagactact      660

ccttacgatg ttgctatcat cggagactac aacattggag gtgatgcttg ggcttctaga      720

atccttcttg aagagatggg actcagagtt gttgctcaat ggtctggtga tggtactctt      780

gttgagatgg aaaacacccc tttcgttaag ctcaacctcg ttcattgcta ccgtagcatg      840

aactacattg ctagacacat ggaagagaag caccaaattc cttggatgga gtacaacttc      900

ttcggaccta ctaagatcgc tgagtctctt agaaagatcg ctgatcagtt cgatgatacc      960

atcagagcta atgctgaggc tgttattgct agatacgagg gacaaatggc tgctattatc     1020

gctaagtaca gacctagact cgagggaaga aaggttttgc tttacatcgg aggactcaga     1080

cctagacatg ttattggagc ttacgaggat ctcggaatgg aaattattgc tgctggatac     1140

gagttcgctc acaacgatga ttacgataga actctccctg acctcaaaga gggaactctt     1200

cttttcgatg acgcttcttc atacgagctt gaggcttttg ttaaggctct taagcctgat     1260

ctcatcggat ctggaatcaa agagaagtac atcttccaga agatgggagt tcctttcaga     1320

cagatgcact cttgggatta ttctggacct taccatggat acgacggatt tgctatcttc     1380

gctagggata tggatatgac tctcaacaat cctgcttgga acgaacttac tgctccttgg     1440

cttaagtctg ctgccggcga ctacaaagac gatgatgaca aacccgggtg atgaggcgcg     1500

cc                                                                    1502


<210>  29
<211>  1631
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AscI fragment

<400>  29
ggcgcgccat ctcaaactat tgataagatc aacagctgct acccactctt tgagcaagat       60

gaataccaag agcttttccg taacaagaga cagcttgaag aggctcatga tgctcagaga      120

gttcaagaag ttttcgcttg gactactact gctgaatacg aggctctcaa ctttagaaga      180

gaggctctta ctgttgaccc tgctaaggct tgtcaacctc ttggagctgt tctttgttct      240

cttggattcg ctaacaccct tccttatgtt catggatctc agggatgtgt ggcttacttc      300

agaacctact tcaacaggca cttcaaagaa cctatcgctt gcgttagcga ttctatgact      360

gaagatgctg ctgttttcgg aggtaacaac aacatgaacc ttggacttca gaacgcttct      420

gctctttaca agcctgagat tatcgctgtg tctactactt gcatggctga agttatcgga      480

gatgatctcc aggctttcat tgctaacgct aagaaggatg gattcgtcga ttcttctatc      540

gctgttcctc atgctcacac tccatctttc atcggatctc atgttaccgg atgggataat      600

atgttcgagg gattcgctaa gaccttcact gctgattatc aaggacagcc tggaaagttg      660

cctaagttga atctcgttac cggattcgag acttacctcg gaaacttcag agtgctcaag      720

agaatgatgg aacagatggc tgtgccttgc tctcttcttt ctgatccttc tgaagtgctc      780

gatactcctg ctgatggaca ttataggatg tactctggtg gaactaccca gcaagaaatg      840

aaggaagctc ctgacgctat cgatactctt cttcttcaac cttggcaact cctcaagtct      900

aagaaagttg tgcaagagat gtggaaccag cctgctactg aagttgctat tcctcttgga      960

cttgctgcta ctgatgagct tctcatgact gtttctcagc tttctggaaa gcctatcgct     1020

gatgctctta ctcttgagag aggtagactc gttgatatga tgctcgattc tcatacttgg     1080

ctccacggaa agaagtttgg actttacgga gatcctgact tcgttatggg acttactaga     1140

ttcttgctcg agcttggatg tgagcctact gttatccttt ctcacaacgc taacaagagg     1200

tggcaaaagg ctatgaacaa gatgcttgat gcttctccat acggaaggga ttctgaggtt     1260

ttcatcaact gcgatctctg gcatttccgt tctctcatgt tcactagaca gcctgatttc     1320

atgatcggaa acagctacgg aaagttcatc cagagagata ctctcgctaa gggaaaggct     1380

ttcgaagttc ctcttatcag acttggattc ccactcttcg atagacatca tctccacaga     1440

caaactactt ggggatatga aggtgctatg aacatcgtta ctaccctcgt taacgctgtt     1500

cttgagaagt tggattctga tacttctcag ctcggaaaga ccgattactc tttcgatctc     1560

gtgagagccg gcggtggagg tggataccct tacgacgttc ctgattacgc tcccgggtga     1620

tgaggcgcgc c                                                          1631


<210>  30
<211>  731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AscI fragment

<400>  30
ggcgcgccat ctgataatga tacacttttt tggaggatgc tcgctctttt ccagtctctt       60

cctgatcttc aacctgctca aatcgttgat tggcttgctc aagaatctgg tgagactctt      120

actcctgaga gacttgctac tcttactcaa cctcaactcg ctgcttcttt tccttctgct      180

actgctgtta tgtctcctgc tagatggtct agagttatgg cttctcttca gggtgctctc      240

ccagctcatc ttagaatcgt tagacctgct caaagaactc ctcaacttct tgctgctttc      300

tgttctcagg atggacttgt tatcaacgga catttcggac agggtagact ctttttcatc      360

tacgcttttg atgagcaggg aggatggctt tacgatctta gaagatatcc ttctgctcct      420

catcagcaag aggctaatga agttagagct agacttatcg aggattgcca gcttttgttc      480

tgtcaagaaa ttggaggacc tgctgctgct agacctatta gacatagaat ccaccctatg      540

aaggctcaac ctggaactac tatccaagct caatgtgagg ctatcaacac tcttcttgct      600

ggtagacttc ctccttggct tgctaaaaga ctcaacagag ataacccgct cgaagagagg      660

gttttcgccg gcggtggagg tggataccct tacgacgttc ctgattacgc tcccgggtga      720

tgaggcgcgc c                                                           731


<210>  31
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  31

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Thr Ser Cys Ser Ser Phe Ser Gly Gly Lys Ala Cys Arg Pro 
        35                  40                  45              


Ala Asp Asp Ser Ala Leu Thr Pro Leu Val Ala Asp Lys Ala Ala Ala 
    50                  55                  60                  


His Pro Cys Tyr Ser Arg His Gly His His Arg Phe Ala Arg Met His 
65                  70                  75                  80  


Leu Pro Val Ala Pro Ala Cys Asn Leu Gln Cys Asn Tyr Cys Asn Arg 
                85                  90                  95      


Lys Phe Asp Cys Ser Asn Glu Ser Arg Pro Gly Val Ser Ser Thr Leu 
            100                 105                 110         


Leu Thr Pro Glu Gln Ala Val Val Lys Val Arg Gln Val Ala Gln Ala 
        115                 120                 125             


Ile Pro Gln Leu Ser Val Val Gly Ile Ala Gly Pro Gly Asp Pro Leu 
    130                 135                 140                 


Ala Asn Ile Ala Arg Thr Phe Arg Thr Leu Glu Leu Ile Arg Glu Gln 
145                 150                 155                 160 


Leu Pro Asp Leu Lys Leu Cys Leu Ser Thr Asn Gly Leu Val Leu Pro 
                165                 170                 175     


Asp Ala Val Asp Arg Leu Leu Asp Val Gly Val Asp His Val Thr Val 
            180                 185                 190         


Thr Ile Asn Thr Leu Asp Ala Glu Ile Ala Ala Gln Ile Tyr Ala Trp 
        195                 200                 205             


Leu Trp Leu Asp Gly Glu Arg Tyr Ser Gly Arg Glu Ala Gly Glu Ile 
    210                 215                 220                 


Leu Ile Ala Arg Gln Leu Glu Gly Val Arg Arg Leu Thr Ala Lys Gly 
225                 230                 235                 240 


Val Leu Val Lys Ile Asn Ser Val Leu Ile Pro Gly Ile Asn Asp Ser 
                245                 250                 255     


Gly Met Ala Gly Val Ser Arg Ala Leu Arg Ala Ser Gly Ala Phe Ile 
            260                 265                 270         


His Asn Ile Met Pro Leu Ile Ala Arg Pro Glu His Gly Thr Val Phe 
        275                 280                 285             


Gly Leu Asn Gly Gln Pro Glu Pro Asp Ala Glu Thr Leu Ala Ala Thr 
    290                 295                 300                 


Arg Ser Arg Cys Gly Glu Val Met Pro Gln Met Thr His Cys His Gln 
305                 310                 315                 320 


Cys Arg Ala Asp Ala Ile Gly Met Leu Gly Glu Asp Arg Ser Gln Gln 
                325                 330                 335     


Phe Thr Gln Leu Pro Ala Pro Glu Ser Leu Pro Ala Trp Leu Pro Ile 
            340                 345                 350         


Leu His Gln Arg Ala Gln Leu His Ala Ser Ile Ala Thr Arg Gly Glu 
        355                 360                 365             


Ser Glu Ala Asp Asp Ala Cys Leu Val Ala Val Ala Ser Ser Arg Gly 
    370                 375                 380                 


Asp Val Ile Asp Cys His Phe Gly His Ala Asp Arg Phe Tyr Ile Tyr 
385                 390                 395                 400 


Ser Leu Ser Ala Ala Gly Met Val Leu Val Asn Glu Arg Phe Thr Pro 
                405                 410                 415     


Lys Tyr Cys Gln Gly Arg Asp Asp Cys Glu Pro Gln Asp Asn Ala Ala 
            420                 425                 430         


Arg Phe Ala Ala Ile Leu Glu Leu Leu Ala Asp Val Lys Ala Val Phe 
        435                 440                 445             


Cys Val Arg Ile Gly His Thr Pro Trp Gln Gln Leu Glu Gln Glu Gly 
    450                 455                 460                 


Ile Glu Pro Cys Val Asp Gly Ala Trp Arg Pro Val Ser Glu Val Leu 
465                 470                 475                 480 


Pro Ala Trp Trp Gln Gln Arg Arg Gly Ser Trp Pro Ala Ala Leu Pro 
                485                 490                 495     


His Lys Gly Val Ala Ala Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val 
            500                 505                 510         


Pro Asp Tyr Ala Pro Gly 
        515             


<210>  32
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  32

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Lys Gly Asn Glu Ile Leu Ala Leu Leu Asp Glu Pro Ala Cys 
        35                  40                  45              


Glu His Asn His Lys Gln Lys Ser Gly Cys Ser Ala Pro Lys Pro Gly 
    50                  55                  60                  


Ala Thr Ala Ala Gly Cys Ala Phe Asp Gly Ala Gln Ile Thr Leu Leu 
65                  70                  75                  80  


Pro Ile Ala Asp Val Ala His Leu Val His Gly Pro Ile Gly Cys Ala 
                85                  90                  95      


Gly Ser Ser Trp Asp Asn Arg Gly Ser Ala Ser Ser Gly Pro Thr Leu 
            100                 105                 110         


Asn Arg Leu Gly Phe Thr Thr Asp Leu Asn Glu Gln Asp Val Ile Met 
        115                 120                 125             


Gly Arg Gly Glu Arg Arg Leu Phe His Ala Val Arg His Ile Val Thr 
    130                 135                 140                 


Arg Tyr His Pro Ala Ala Val Phe Ile Tyr Asn Thr Cys Val Pro Ala 
145                 150                 155                 160 


Met Glu Gly Asp Asp Leu Glu Ala Val Cys Gln Ala Ala Gln Thr Ala 
                165                 170                 175     


Thr Gly Val Pro Val Ile Ala Ile Asp Ala Ala Gly Phe Tyr Gly Ser 
            180                 185                 190         


Lys Asn Leu Gly Asn Arg Pro Ala Gly Asp Val Met Val Lys Arg Val 
        195                 200                 205             


Ile Gly Gln Arg Glu Pro Ala Pro Trp Pro Glu Ser Thr Leu Phe Ala 
    210                 215                 220                 


Pro Glu Gln Arg His Asp Ile Gly Leu Ile Gly Glu Phe Asn Ile Ala 
225                 230                 235                 240 


Gly Glu Phe Trp His Ile Gln Pro Leu Leu Asp Glu Leu Gly Ile Arg 
                245                 250                 255     


Val Leu Gly Ser Leu Ser Gly Asp Gly Arg Phe Ala Glu Ile Gln Thr 
            260                 265                 270         


Met His Arg Ala Gln Ala Asn Met Leu Val Cys Ser Arg Ala Leu Ile 
        275                 280                 285             


Asn Val Ala Arg Ala Leu Glu Gln Arg Tyr Gly Thr Pro Trp Phe Glu 
    290                 295                 300                 


Gly Ser Phe Tyr Gly Ile Arg Ala Thr Ser Asp Ala Leu Arg Gln Leu 
305                 310                 315                 320 


Ala Ala Leu Leu Gly Asp Asp Asp Leu Arg Gln Arg Thr Glu Ala Leu 
                325                 330                 335     


Ile Ala Arg Glu Glu Gln Ala Ala Glu Leu Ala Leu Gln Pro Trp Arg 
            340                 345                 350         


Glu Gln Leu Arg Gly Arg Lys Ala Leu Leu Tyr Thr Gly Gly Val Lys 
        355                 360                 365             


Ser Trp Ser Val Val Ser Ala Leu Gln Asp Leu Gly Met Thr Val Val 
    370                 375                 380                 


Ala Thr Gly Thr Arg Lys Ser Thr Glu Glu Asp Lys Gln Arg Ile Arg 
385                 390                 395                 400 


Glu Leu Met Gly Glu Glu Ala Val Met Leu Glu Glu Gly Asn Ala Arg 
                405                 410                 415     


Thr Leu Leu Asp Val Val Tyr Arg Tyr Gln Ala Asp Leu Met Ile Ala 
            420                 425                 430         


Gly Gly Arg Asn Met Tyr Thr Ala Tyr Lys Ala Arg Leu Pro Phe Leu 
        435                 440                 445             


Asp Ile Asn Gln Glu Arg Glu His Ala Phe Ala Gly Tyr Gln Gly Ile 
    450                 455                 460                 


Val Thr Leu Ala Arg Gln Leu Cys Gln Thr Ile Asn Ser Pro Ile Trp 
465                 470                 475                 480 


Pro Gln Thr His Ser Arg Ala Pro Trp Arg Ala Gly Gly Gly Gly Gly 
                485                 490                 495     


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
            500                 505         


<210>  33
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  33

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Ala Asp Ile Phe Arg Thr Asp Lys Pro Leu Ala Val Ser Pro 
        35                  40                  45              


Ile Lys Thr Gly Gln Pro Leu Gly Ala Ile Leu Ala Ser Leu Gly Ile 
    50                  55                  60                  


Glu His Ser Ile Pro Leu Val His Gly Ala Gln Gly Cys Ser Ala Phe 
65                  70                  75                  80  


Ala Lys Val Phe Phe Ile Gln His Phe His Asp Pro Val Pro Leu Gln 
                85                  90                  95      


Ser Thr Ala Met Asp Pro Thr Ser Thr Ile Met Gly Ala Asp Gly Asn 
            100                 105                 110         


Ile Phe Thr Ala Leu Asp Thr Leu Cys Gln Arg Asn Asn Pro Gln Ala 
        115                 120                 125             


Ile Val Leu Leu Ser Thr Gly Leu Ser Glu Ala Gln Gly Ser Asp Ile 
    130                 135                 140                 


Ser Arg Val Val Arg Gln Phe Arg Glu Glu Tyr Pro Arg His Lys Gly 
145                 150                 155                 160 


Val Ala Ile Leu Thr Val Asn Thr Pro Asp Phe Tyr Gly Ser Met Glu 
                165                 170                 175     


Asn Gly Phe Ser Ala Val Leu Glu Ser Val Ile Glu Gln Trp Val Pro 
            180                 185                 190         


Pro Ala Pro Arg Pro Ala Gln Arg Asn Arg Arg Val Asn Leu Leu Val 
        195                 200                 205             


Ser His Leu Cys Ser Pro Gly Asp Ile Glu Trp Leu Arg Arg Cys Val 
    210                 215                 220                 


Glu Ala Phe Gly Leu Gln Pro Ile Ile Leu Pro Asp Leu Ala Gln Ser 
225                 230                 235                 240 


Met Asp Gly His Leu Ala Gln Gly Asp Phe Ser Pro Leu Thr Gln Gly 
                245                 250                 255     


Gly Thr Pro Leu Arg Gln Ile Glu Gln Met Gly Gln Ser Leu Cys Ser 
            260                 265                 270         


Phe Ala Ile Gly Val Ser Leu His Arg Ala Ser Ser Leu Leu Ala Pro 
        275                 280                 285             


Arg Cys Arg Gly Glu Val Ile Ala Leu Pro His Leu Met Thr Leu Glu 
    290                 295                 300                 


Arg Cys Asp Ala Phe Ile His Gln Leu Ala Lys Ile Ser Gly Arg Ala 
305                 310                 315                 320 


Val Pro Glu Trp Leu Glu Arg Gln Arg Gly Gln Leu Gln Asp Ala Met 
                325                 330                 335     


Ile Asp Cys His Met Trp Leu Gln Gly Gln Arg Met Ala Ile Ala Ala 
            340                 345                 350         


Glu Gly Asp Leu Leu Ala Ala Trp Cys Asp Phe Ala Asn Ser Gln Gly 
        355                 360                 365             


Met Gln Pro Gly Pro Leu Val Ala Pro Thr Gly His Pro Ser Leu Arg 
    370                 375                 380                 


Gln Leu Pro Val Glu Arg Val Val Pro Gly Asp Leu Glu Asp Leu Gln 
385                 390                 395                 400 


Thr Leu Leu Cys Ala His Pro Ala Asp Leu Leu Val Ala Asn Ser His 
                405                 410                 415     


Ala Arg Asp Leu Ala Glu Gln Phe Ala Leu Pro Leu Val Arg Ala Gly 
            420                 425                 430         


Phe Pro Leu Phe Asp Lys Leu Gly Glu Phe Arg Arg Val Arg Gln Gly 
        435                 440                 445             


Tyr Ser Gly Met Arg Asp Thr Leu Phe Glu Leu Ala Asn Leu Ile Arg 
    450                 455                 460                 


Glu Arg His His His Leu Ala His Tyr Arg Ser Pro Leu Arg Gln Asn 
465                 470                 475                 480 


Pro Glu Ser Ser Leu Ser Thr Gly Gly Ala Tyr Ala Ala Ala Gly Asp 
                485                 490                 495     


Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
            500                 505 


<210>  34
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  34

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Pro Pro Leu Asp Trp Leu Arg Arg Leu Trp Leu Leu Tyr His 
        35                  40                  45              


Ala Gly Lys Gly Ser Phe Pro Leu Arg Met Gly Leu Ser Pro Arg Asp 
    50                  55                  60                  


Trp Gln Ala Leu Arg Arg Arg Leu Gly Glu Val Glu Thr Pro Leu Asp 
65                  70                  75                  80  


Gly Glu Thr Leu Thr Arg Arg Arg Leu Met Ala Glu Leu Asn Ala Thr 
                85                  90                  95      


Arg Glu Glu Glu Arg Gln Gln Leu Gly Ala Trp Leu Ala Gly Trp Met 
            100                 105                 110         


Gln Gln Asp Ala Gly Pro Met Ala Gln Ile Ile Ala Glu Val Ser Leu 
        115                 120                 125             


Ala Phe Asn His Leu Trp Gln Asp Leu Gly Leu Ala Ser Arg Ala Glu 
    130                 135                 140                 


Leu Arg Leu Leu Met Ser Asp Cys Phe Pro Gln Leu Val Val Met Asn 
145                 150                 155                 160 


Glu His Asn Met Arg Trp Lys Lys Phe Phe Tyr Arg Gln Arg Cys Leu 
                165                 170                 175     


Leu Gln Gln Gly Glu Val Ile Cys Arg Ser Pro Ser Cys Asp Glu Cys 
            180                 185                 190         


Trp Glu Arg Ser Ala Cys Phe Glu Ala Gly Gly Gly Gly Gly Tyr Pro 
        195                 200                 205             


Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
    210                 215         


<210>  35
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  35

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Lys Gln Val Tyr Leu Asp Asn Asn Ala Thr Thr Arg Leu Asp 
        35                  40                  45              


Pro Met Val Leu Glu Ala Met Met Pro Phe Leu Thr Asp Phe Tyr Gly 
    50                  55                  60                  


Asn Pro Ser Ser Ile His Asp Phe Gly Ile Pro Ala Gln Ala Ala Leu 
65                  70                  75                  80  


Glu Arg Ala His Gln Gln Ala Ala Ala Leu Leu Gly Ala Glu Tyr Pro 
                85                  90                  95      


Ser Glu Ile Ile Phe Thr Ser Cys Ala Thr Glu Ala Thr Ala Thr Ala 
            100                 105                 110         


Ile Ala Ser Ala Ile Ala Leu Leu Pro Glu Arg Arg Glu Ile Ile Thr 
        115                 120                 125             


Ser Val Val Glu His Pro Ala Thr Leu Ala Ala Cys Glu His Met Glu 
    130                 135                 140                 


Arg Glu Gly Tyr Arg Ile His Arg Ile Ala Val Asp Gly Glu Gly Ala 
145                 150                 155                 160 


Leu Asp Met Ala Gln Phe Arg Ala Ala Leu Ser Pro Arg Val Ala Leu 
                165                 170                 175     


Val Ser Val Met Trp Ala Asn Asn Glu Thr Gly Val Leu Phe Pro Ile 
            180                 185                 190         


Gly Glu Met Ala Glu Leu Ala His Glu Gln Gly Ala Leu Phe His Cys 
        195                 200                 205             


Asp Ala Val Gln Val Val Gly Lys Ile Pro Ile Ala Val Gly Gln Thr 
    210                 215                 220                 


Arg Ile Asp Met Leu Ser Cys Ser Ala His Lys Phe His Gly Pro Lys 
225                 230                 235                 240 


Gly Val Gly Cys Leu Tyr Leu Arg Arg Gly Thr Arg Phe Arg Pro Leu 
                245                 250                 255     


Leu Arg Gly Gly His Gln Glu Tyr Gly Arg Arg Ala Gly Thr Glu Asn 
            260                 265                 270         


Ile Cys Gly Ile Val Gly Met Gly Ala Ala Cys Glu Leu Ala Asn Ile 
        275                 280                 285             


His Leu Pro Gly Met Thr His Ile Gly Gln Leu Arg Asn Arg Leu Glu 
    290                 295                 300                 


His Arg Leu Leu Ala Ser Val Pro Ser Val Met Val Met Gly Gly Gly 
305                 310                 315                 320 


Gln Pro Ala Val Pro Gly Thr Val Asn Leu Ala Phe Glu Phe Ile Glu 
                325                 330                 335     


Gly Glu Ala Ile Leu Leu Leu Leu Asn Gln Ala Gly Ile Ala Ala Ser 
            340                 345                 350         


Ser Gly Ser Ala Cys Thr Ser Gly Ser Leu Glu Pro Ser His Val Met 
        355                 360                 365             


Arg Ala Met Asn Ile Pro Tyr Thr Ala Ala His Gly Thr Ile Arg Phe 
    370                 375                 380                 


Ser Leu Ser Arg Tyr Thr Arg Glu Lys Glu Ile Asp Tyr Val Val Ala 
385                 390                 395                 400 


Thr Leu Pro Pro Ile Ile Asp Arg Leu Arg Ala Leu Ser Pro Tyr Trp 
                405                 410                 415     


Gln Asn Gly Lys Pro Arg Pro Ala Asp Ala Val Phe Thr Pro Val Tyr 
            420                 425                 430         


Gly Ala Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
        435                 440                 445             


Pro Gly 
    450 


<210>  36
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion polypeptide

<400>  36

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Trp Asn Tyr Ser Glu Lys Val Lys Asp His Phe Phe Asn Pro 
        35                  40                  45              


Arg Asn Ala Arg Val Val Asp Asn Ala Asn Ala Val Gly Asp Val Gly 
    50                  55                  60                  


Ser Leu Ser Cys Gly Asp Ala Leu Arg Leu Met Leu Arg Val Asp Pro 
65                  70                  75                  80  


Gln Ser Glu Ile Ile Glu Glu Ala Gly Phe Gln Thr Phe Gly Cys Gly 
                85                  90                  95      


Ser Ala Ile Ala Ser Ser Ser Ala Leu Thr Glu Leu Ile Ile Gly His 
            100                 105                 110         


Thr Leu Ala Glu Ala Gly Gln Ile Thr Asn Gln Gln Ile Ala Asp Tyr 
        115                 120                 125             


Leu Asp Gly Leu Pro Pro Glu Lys Met His Cys Ser Val Met Gly Gln 
    130                 135                 140                 


Glu Ala Leu Arg Ala Ala Ile Ala Asn Phe Arg Gly Glu Ser Leu Glu 
145                 150                 155                 160 


Glu Glu His Asp Glu Gly Lys Leu Ile Cys Lys Cys Phe Gly Val Asp 
                165                 170                 175     


Glu Gly His Ile Arg Arg Ala Val Gln Asn Asn Gly Leu Thr Thr Leu 
            180                 185                 190         


Ala Glu Val Ile Asn Tyr Thr Lys Ala Gly Gly Gly Cys Thr Ser Cys 
        195                 200                 205             


His Glu Lys Ile Glu Leu Ala Leu Ala Glu Ile Leu Ala Gln Gln Pro 
    210                 215                 220                 


Gln Thr Thr Pro Ala Val Ala Ser Gly Lys Asp Pro His Trp Gln Ser 
225                 230                 235                 240 


Val Val Asp Thr Ile Ala Glu Leu Arg Pro His Ile Gln Ala Asp Gly 
                245                 250                 255     


Gly Asp Met Ala Leu Leu Ser Val Thr Asn His Gln Val Thr Val Ser 
            260                 265                 270         


Leu Ser Gly Ser Cys Ser Gly Cys Met Met Thr Asp Met Thr Leu Ala 
        275                 280                 285             


Trp Leu Gln Gln Lys Leu Met Glu Arg Thr Gly Cys Tyr Met Glu Val 
    290                 295                 300                 


Val Ala Ala Ala Gly Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
305                 310                 315                 


<210>  37
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  37

Met Gly Leu Ser Leu Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala 
1               5                   10                  15      


Thr Arg Thr Leu Cys Ser Ser Arg Tyr Leu Leu Glu Gln Lys Pro Gly 
            20                  25                  30          


Ala Pro Pro Pro Ile Asn Arg Gln Phe Asp Met Val His Ser Asp Glu 
        35                  40                  45              


Trp Ser Met Lys Val Ala Phe Ala Ser Ser Asp Tyr Arg His Val Asp 
    50                  55                  60                  


Gln His Phe Gly Ala Thr Pro Arg Leu Val Val Tyr Gly Val Lys Ala 
65                  70                  75                  80  


Asp Arg Val Thr Leu Ile Arg Val Val Asp Phe Ser Val Glu Asn Gly 
                85                  90                  95      


His Gln Thr Glu Lys Ile Ala Arg Arg Ile His Ala Leu Glu Asp Cys 
            100                 105                 110         


Val Thr Leu Phe Cys Val Ala Ile Gly Asp Ala Val Phe Arg Gln Leu 
        115                 120                 125             


Leu Gln Val Gly Val Arg Ala Glu Arg Val Pro Ala Asp Thr Thr Ile 
    130                 135                 140                 


Val Gly Leu Leu Gln Glu Ile Gln Leu Tyr Trp Tyr Asp Lys Gly Gln 
145                 150                 155                 160 


Arg Lys Asn Gln Arg Gln Arg Asp Pro Glu Arg Phe Thr Arg Leu Leu 
                165                 170                 175     


Gln Glu Gln Glu Trp His Gly Asp Pro Asp Pro Arg Arg Ala Gly Asp 
            180                 185                 190         


Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
        195                 200     


<210>  38
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  38

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


<210>  39
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  39

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Arg Pro Ile Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Glu Glu Gly Leu Leu Ala Ala Ala Ala Ala Ala Ala Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


<210>  40
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  40

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Met Ala Asn Ile Gly Ile Phe Phe Gly Thr Asp Thr Gly Lys Thr Arg 
                85                  90                  95      


Lys Ile Ala Lys Met Ile His Lys Gln Leu Gly Glu Leu Ala Asp Ala 
            100                 105                 110         


Pro Val Asn Ile Asn Arg Thr Thr Leu Asp Asp Phe Met Ala Tyr Pro 
        115                 120                 125             


Val Leu Leu Leu Gly Thr Pro Thr Leu Gly Asp Gly Gln Leu Pro Gly 
    130                 135                 140                 


Leu Glu Ala Gly Cys Glu Ser Glu Ser Trp Ser Glu Phe Ile Ser Gly 
145                 150                 155                 160 


Leu Asp Asp Ala Ser Leu Lys Gly Lys Thr Val Ala Leu Phe Gly Leu 
                165                 170                 175     


Gly Asp Gln Arg Gly Tyr Pro Asp Asn Phe Val Ser Gly Met Arg Pro 
            180                 185                 190         


Leu Phe Asp Ala Leu Ser Ala Arg Gly Ala Gln Met Ile Gly Ser Trp 
        195                 200                 205             


Pro Asn Glu Gly Tyr Glu Phe Ser Ala Ser Ser Ala Leu Glu Gly Asp 
    210                 215                 220                 


Arg Phe Val Gly Leu Val Leu Asp Gln Asp Asn Gln Phe Asp Gln Thr 
225                 230                 235                 240 


Glu Ala Arg Leu Ala Ser Trp Leu Glu Glu Ile Lys Arg Thr Val Leu 
                245                 250                 255     


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
            260                 265         


<210>  41
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  41

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Met Arg Pro Lys Phe Thr Phe Ser Glu Glu Val Arg Val Val Arg Ala 
                85                  90                  95      


Ile Arg Asn Asp Gly Thr Val Ala Gly Phe Ala Pro Gly Ala Leu Leu 
            100                 105                 110         


Val Arg Arg Gly Ser Thr Gly Phe Val Arg Asp Trp Gly Val Phe Leu 
        115                 120                 125             


Gln Asp Gln Ile Ile Tyr Gln Ile His Phe Pro Glu Thr Asp Arg Ile 
    130                 135                 140                 


Ile Gly Cys Arg Glu Gln Glu Leu Ile Pro Ile Thr Gln Pro Trp Leu 
145                 150                 155                 160 


Ala Gly Asn Leu Gln Tyr Arg Asp Ser Val Thr Cys Gln Met Ala Leu 
                165                 170                 175     


Ala Val Asn Gly Asp Val Val Val Ser Ala Gly Gln Arg Gly Arg Val 
            180                 185                 190         


Glu Ala Thr Asp Arg Gly Glu Leu Gly Asp Ser Tyr Thr Val Asp Phe 
        195                 200                 205             


Ser Gly Arg Trp Phe Arg Val Pro Val Gln Ala Ile Ala Leu Ile Glu 
    210                 215                 220                 


Glu Arg Glu Glu Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
225                 230                 235             


<210>  42
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  42

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Thr Met Arg Gln Cys Ala Ile Tyr Gly Lys Gly Gly Ile Gly Lys Ser 
                85                  90                  95      


Thr Thr Thr Gln Asn Leu Val Ala Ala Leu Ala Glu Met Gly Lys Lys 
            100                 105                 110         


Val Met Ile Val Gly Cys Asp Pro Lys Ala Asp Ser Thr Arg Leu Ile 
        115                 120                 125             


Leu His Ala Lys Ala Gln Asn Thr Ile Met Glu Met Ala Ala Glu Val 
    130                 135                 140                 


Gly Ser Val Glu Asp Leu Glu Leu Glu Asp Val Leu Gln Ile Gly Tyr 
145                 150                 155                 160 


Gly Asp Val Arg Cys Ala Glu Ser Gly Gly Pro Glu Pro Gly Val Gly 
                165                 170                 175     


Cys Ala Gly Arg Gly Val Ile Thr Ala Ile Asn Phe Leu Glu Glu Glu 
            180                 185                 190         


Gly Ala Tyr Glu Asp Asp Leu Asp Phe Val Phe Tyr Asp Val Leu Gly 
        195                 200                 205             


Asp Val Val Cys Gly Gly Phe Ala Met Pro Ile Arg Glu Asn Lys Ala 
    210                 215                 220                 


Gln Glu Ile Tyr Ile Val Cys Ser Gly Glu Met Met Ala Met Tyr Ala 
225                 230                 235                 240 


Ala Asn Asn Ile Ser Lys Gly Ile Val Lys Tyr Ala Lys Ser Gly Lys 
                245                 250                 255     


Val Arg Leu Gly Gly Leu Ile Cys Asn Ser Arg Gln Thr Asp Arg Glu 
            260                 265                 270         


Asp Glu Leu Ile Ile Ala Leu Ala Glu Lys Leu Gly Thr Gln Met Ile 
        275                 280                 285             


His Phe Val Pro Arg Asp Asn Ile Val Gln Arg Ala Glu Ile Arg Arg 
    290                 295                 300                 


Met Thr Val Ile Glu Tyr Asp Pro Ala Cys Lys Gln Ala Asn Glu Tyr 
305                 310                 315                 320 


Arg Thr Leu Ala Gln Lys Ile Val Asn Asn Thr Met Lys Val Val Pro 
                325                 330                 335     


Thr Pro Cys Thr Met Asp Glu Leu Glu Ser Leu Leu Met Glu Phe Gly 
            340                 345                 350         


Ile Met Glu Glu Glu Asp Thr Ser Ile Ile Gly Lys Thr Ala Ala Glu 
        355                 360                 365             


Glu Asn Ala Ala Ala Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro 
    370                 375                 380                 


Asp Tyr Ala Pro Gly 
385                 


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptide

<400>  43

Ser Ile Ser Thr Gln Val Val Arg 
1               5               


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptide

<400>  44

Ile Ser Thr Gln Val Val Arg 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptide

<400>  45

Ala Val Gln Gly Ala Pro Thr Met Arg 
1               5                   


<210>  46
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  46

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Thr Ser Cys Ser Ser Phe Ser Gly Gly Lys Ala Cys Arg Pro Ala Asp 
                85                  90                  95      


Asp Ser Ala Leu Thr Pro Leu Val Ala Asp Lys Ala Ala Ala His Pro 
            100                 105                 110         


Cys Tyr Ser Arg His Gly His His Arg Phe Ala Arg Met His Leu Pro 
        115                 120                 125             


Val Ala Pro Ala Cys Asn Leu Gln Cys Asn Tyr Cys Asn Arg Lys Phe 
    130                 135                 140                 


Asp Cys Ser Asn Glu Ser Arg Pro Gly Val Ser Ser Thr Leu Leu Thr 
145                 150                 155                 160 


Pro Glu Gln Ala Val Val Lys Val Arg Gln Val Ala Gln Ala Ile Pro 
                165                 170                 175     


Gln Leu Ser Val Val Gly Ile Ala Gly Pro Gly Asp Pro Leu Ala Asn 
            180                 185                 190         


Ile Ala Arg Thr Phe Arg Thr Leu Glu Leu Ile Arg Glu Gln Leu Pro 
        195                 200                 205             


Asp Leu Lys Leu Cys Leu Ser Thr Asn Gly Leu Val Leu Pro Asp Ala 
    210                 215                 220                 


Val Asp Arg Leu Leu Asp Val Gly Val Asp His Val Thr Val Thr Ile 
225                 230                 235                 240 


Asn Thr Leu Asp Ala Glu Ile Ala Ala Gln Ile Tyr Ala Trp Leu Trp 
                245                 250                 255     


Leu Asp Gly Glu Arg Tyr Ser Gly Arg Glu Ala Gly Glu Ile Leu Ile 
            260                 265                 270         


Ala Arg Gln Leu Glu Gly Val Arg Arg Leu Thr Ala Lys Gly Val Leu 
        275                 280                 285             


Val Lys Ile Asn Ser Val Leu Ile Pro Gly Ile Asn Asp Ser Gly Met 
    290                 295                 300                 


Ala Gly Val Ser Arg Ala Leu Arg Ala Ser Gly Ala Phe Ile His Asn 
305                 310                 315                 320 


Ile Met Pro Leu Ile Ala Arg Pro Glu His Gly Thr Val Phe Gly Leu 
                325                 330                 335     


Asn Gly Gln Pro Glu Pro Asp Ala Glu Thr Leu Ala Ala Thr Arg Ser 
            340                 345                 350         


Arg Cys Gly Glu Val Met Pro Gln Met Thr His Cys His Gln Cys Arg 
        355                 360                 365             


Ala Asp Ala Ile Gly Met Leu Gly Glu Asp Arg Ser Gln Gln Phe Thr 
    370                 375                 380                 


Gln Leu Pro Ala Pro Glu Ser Leu Pro Ala Trp Leu Pro Ile Leu His 
385                 390                 395                 400 


Gln Arg Ala Gln Leu His Ala Ser Ile Ala Thr Arg Gly Glu Ser Glu 
                405                 410                 415     


Ala Asp Asp Ala Cys Leu Val Ala Val Ala Ser Ser Arg Gly Asp Val 
            420                 425                 430         


Ile Asp Cys His Phe Gly His Ala Asp Arg Phe Tyr Ile Tyr Ser Leu 
        435                 440                 445             


Ser Ala Ala Gly Met Val Leu Val Asn Glu Arg Phe Thr Pro Lys Tyr 
    450                 455                 460                 


Cys Gln Gly Arg Asp Asp Cys Glu Pro Gln Asp Asn Ala Ala Arg Phe 
465                 470                 475                 480 


Ala Ala Ile Leu Glu Leu Leu Ala Asp Val Lys Ala Val Phe Cys Val 
                485                 490                 495     


Arg Ile Gly His Thr Pro Trp Gln Gln Leu Glu Gln Glu Gly Ile Glu 
            500                 505                 510         


Pro Cys Val Asp Gly Ala Trp Arg Pro Val Ser Glu Val Leu Pro Ala 
        515                 520                 525             


Trp Trp Gln Gln Arg Arg Gly Ser Trp Pro Ala Ala Leu Pro His Lys 
    530                 535                 540                 


Gly Val Ala Ala Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp 
545                 550                 555                 560 


Tyr Ala Pro Gly 
                


<210>  47
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  47

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Thr Asn Ala Thr Gly Glu Arg Asn Leu Ala Leu Ile Gln Glu Val Leu 
                85                  90                  95      


Glu Val Phe Pro Glu Thr Ala Arg Lys Glu Arg Arg Lys His Met Met 
            100                 105                 110         


Val Ser Asp Pro Lys Met Lys Ser Val Gly Lys Cys Ile Ile Ser Asn 
        115                 120                 125             


Arg Lys Ser Gln Pro Gly Val Met Thr Val Arg Gly Cys Ala Tyr Ala 
    130                 135                 140                 


Gly Ser Lys Gly Val Val Phe Gly Pro Ile Lys Asp Met Ala His Ile 
145                 150                 155                 160 


Ser His Gly Pro Ala Gly Cys Gly Gln Tyr Ser Arg Ala Glu Arg Arg 
                165                 170                 175     


Asn Tyr Tyr Thr Gly Val Ser Gly Val Asp Ser Phe Gly Thr Leu Asn 
            180                 185                 190         


Phe Thr Ser Asp Phe Gln Glu Arg Asp Ile Val Phe Gly Gly Asp Lys 
        195                 200                 205             


Lys Leu Ser Lys Leu Ile Glu Glu Met Glu Leu Leu Phe Pro Leu Thr 
    210                 215                 220                 


Lys Gly Ile Thr Ile Gln Ser Glu Cys Pro Val Gly Leu Ile Gly Asp 
225                 230                 235                 240 


Asp Ile Ser Ala Val Ala Asn Ala Ser Ser Lys Ala Leu Asp Lys Pro 
                245                 250                 255     


Val Ile Pro Val Arg Cys Glu Gly Phe Arg Gly Val Ser Gln Ser Leu 
            260                 265                 270         


Gly His His Ile Ala Asn Asp Val Val Arg Asp Trp Ile Leu Asn Asn 
        275                 280                 285             


Arg Glu Gly Gln Pro Phe Glu Thr Thr Pro Tyr Asp Val Ala Ile Ile 
    290                 295                 300                 


Gly Asp Tyr Asn Ile Gly Gly Asp Ala Trp Ala Ser Arg Ile Leu Leu 
305                 310                 315                 320 


Glu Glu Met Gly Leu Arg Val Val Ala Gln Trp Ser Gly Asp Gly Thr 
                325                 330                 335     


Leu Val Glu Met Glu Asn Thr Pro Phe Val Lys Leu Asn Leu Val His 
            340                 345                 350         


Cys Tyr Arg Ser Met Asn Tyr Ile Ala Arg His Met Glu Glu Lys His 
        355                 360                 365             


Gln Ile Pro Trp Met Glu Tyr Asn Phe Phe Gly Pro Thr Lys Ile Ala 
    370                 375                 380                 


Glu Ser Leu Arg Lys Ile Ala Asp Gln Phe Asp Asp Thr Ile Arg Ala 
385                 390                 395                 400 


Asn Ala Glu Ala Val Ile Ala Arg Tyr Glu Gly Gln Met Ala Ala Ile 
                405                 410                 415     


Ile Ala Lys Tyr Arg Pro Arg Leu Glu Gly Arg Lys Val Leu Leu Tyr 
            420                 425                 430         


Ile Gly Gly Leu Arg Pro Arg His Val Ile Gly Ala Tyr Glu Asp Leu 
        435                 440                 445             


Gly Met Glu Ile Ile Ala Ala Gly Tyr Glu Phe Ala His Asn Asp Asp 
    450                 455                 460                 


Tyr Asp Arg Thr Leu Pro Asp Leu Lys Glu Gly Thr Leu Leu Phe Asp 
465                 470                 475                 480 


Asp Ala Ser Ser Tyr Glu Leu Glu Ala Phe Val Lys Ala Leu Lys Pro 
                485                 490                 495     


Asp Leu Ile Gly Ser Gly Ile Lys Glu Lys Tyr Ile Phe Gln Lys Met 
            500                 505                 510         


Gly Val Pro Phe Arg Gln Met His Ser Trp Asp Tyr Ser Gly Pro Tyr 
        515                 520                 525             


His Gly Tyr Asp Gly Phe Ala Ile Phe Ala Arg Asp Met Asp Met Thr 
    530                 535                 540                 


Leu Asn Asn Pro Ala Trp Asn Glu Leu Thr Ala Pro Trp Leu Lys Ser 
545                 550                 555                 560 


Ala Ala Gly Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
                565                 570             


<210>  48
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  48

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Lys Gly Asn Glu Ile Leu Ala Leu Leu Asp Glu Pro Ala Cys Glu His 
                85                  90                  95      


Asn His Lys Gln Lys Ser Gly Cys Ser Ala Pro Lys Pro Gly Ala Thr 
            100                 105                 110         


Ala Ala Gly Cys Ala Phe Asp Gly Ala Gln Ile Thr Leu Leu Pro Ile 
        115                 120                 125             


Ala Asp Val Ala His Leu Val His Gly Pro Ile Gly Cys Ala Gly Ser 
    130                 135                 140                 


Ser Trp Asp Asn Arg Gly Ser Ala Ser Ser Gly Pro Thr Leu Asn Arg 
145                 150                 155                 160 


Leu Gly Phe Thr Thr Asp Leu Asn Glu Gln Asp Val Ile Met Gly Arg 
                165                 170                 175     


Gly Glu Arg Arg Leu Phe His Ala Val Arg His Ile Val Thr Arg Tyr 
            180                 185                 190         


His Pro Ala Ala Val Phe Ile Tyr Asn Thr Cys Val Pro Ala Met Glu 
        195                 200                 205             


Gly Asp Asp Leu Glu Ala Val Cys Gln Ala Ala Gln Thr Ala Thr Gly 
    210                 215                 220                 


Val Pro Val Ile Ala Ile Asp Ala Ala Gly Phe Tyr Gly Ser Lys Asn 
225                 230                 235                 240 


Leu Gly Asn Arg Pro Ala Gly Asp Val Met Val Lys Arg Val Ile Gly 
                245                 250                 255     


Gln Arg Glu Pro Ala Pro Trp Pro Glu Ser Thr Leu Phe Ala Pro Glu 
            260                 265                 270         


Gln Arg His Asp Ile Gly Leu Ile Gly Glu Phe Asn Ile Ala Gly Glu 
        275                 280                 285             


Phe Trp His Ile Gln Pro Leu Leu Asp Glu Leu Gly Ile Arg Val Leu 
    290                 295                 300                 


Gly Ser Leu Ser Gly Asp Gly Arg Phe Ala Glu Ile Gln Thr Met His 
305                 310                 315                 320 


Arg Ala Gln Ala Asn Met Leu Val Cys Ser Arg Ala Leu Ile Asn Val 
                325                 330                 335     


Ala Arg Ala Leu Glu Gln Arg Tyr Gly Thr Pro Trp Phe Glu Gly Ser 
            340                 345                 350         


Phe Tyr Gly Ile Arg Ala Thr Ser Asp Ala Leu Arg Gln Leu Ala Ala 
        355                 360                 365             


Leu Leu Gly Asp Asp Asp Leu Arg Gln Arg Thr Glu Ala Leu Ile Ala 
    370                 375                 380                 


Arg Glu Glu Gln Ala Ala Glu Leu Ala Leu Gln Pro Trp Arg Glu Gln 
385                 390                 395                 400 


Leu Arg Gly Arg Lys Ala Leu Leu Tyr Thr Gly Gly Val Lys Ser Trp 
                405                 410                 415     


Ser Val Val Ser Ala Leu Gln Asp Leu Gly Met Thr Val Val Ala Thr 
            420                 425                 430         


Gly Thr Arg Lys Ser Thr Glu Glu Asp Lys Gln Arg Ile Arg Glu Leu 
        435                 440                 445             


Met Gly Glu Glu Ala Val Met Leu Glu Glu Gly Asn Ala Arg Thr Leu 
    450                 455                 460                 


Leu Asp Val Val Tyr Arg Tyr Gln Ala Asp Leu Met Ile Ala Gly Gly 
465                 470                 475                 480 


Arg Asn Met Tyr Thr Ala Tyr Lys Ala Arg Leu Pro Phe Leu Asp Ile 
                485                 490                 495     


Asn Gln Glu Arg Glu His Ala Phe Ala Gly Tyr Gln Gly Ile Val Thr 
            500                 505                 510         


Leu Ala Arg Gln Leu Cys Gln Thr Ile Asn Ser Pro Ile Trp Pro Gln 
        515                 520                 525             


Thr His Ser Arg Ala Pro Trp Arg Ala Gly Gly Gly Gly Gly Tyr Pro 
    530                 535                 540                 


Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
545                 550             


<210>  49
<211>  1261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  49

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Met Ser Gly Lys Met Lys Thr Met Asp Gly Asn Ala Ala Ala Ala Trp 
                85                  90                  95      


Ile Ser Tyr Ala Phe Thr Glu Val Ala Ala Ile Tyr Pro Ile Thr Pro 
            100                 105                 110         


Ser Thr Pro Met Ala Glu Asn Val Asp Glu Trp Ala Ala Gln Gly Lys 
        115                 120                 125             


Lys Asn Leu Phe Gly Gln Pro Val Arg Leu Met Glu Met Gln Ser Glu 
    130                 135                 140                 


Ala Gly Ala Ala Gly Ala Val His Gly Ala Leu Gln Ala Gly Ala Leu 
145                 150                 155                 160 


Thr Thr Thr Tyr Thr Ala Ser Gln Gly Leu Leu Leu Met Ile Pro Asn 
                165                 170                 175     


Met Tyr Lys Ile Ala Gly Glu Leu Leu Pro Gly Val Phe His Val Ser 
            180                 185                 190         


Ala Arg Ala Leu Ala Thr Asn Ser Leu Asn Ile Phe Gly Asp His Gln 
        195                 200                 205             


Asp Val Met Ala Val Arg Gln Thr Gly Cys Ala Met Leu Ala Glu Asn 
    210                 215                 220                 


Asn Val Gln Gln Val Met Asp Leu Ser Ala Val Ala His Leu Ala Ala 
225                 230                 235                 240 


Ile Lys Gly Arg Ile Pro Phe Val Asn Phe Phe Asp Gly Phe Arg Thr 
                245                 250                 255     


Ser His Glu Ile Gln Lys Ile Glu Val Leu Glu Tyr Glu Gln Leu Ala 
            260                 265                 270         


Thr Leu Leu Asp Arg Pro Ala Leu Asp Ser Phe Arg Arg Asn Ala Leu 
        275                 280                 285             


His Pro Asp His Pro Val Ile Arg Gly Thr Ala Gln Asn Pro Asp Ile 
    290                 295                 300                 


Tyr Phe Gln Glu Arg Glu Ala Gly Asn Arg Phe Tyr Gln Ala Leu Pro 
305                 310                 315                 320 


Asp Ile Val Glu Ser Tyr Met Thr Gln Ile Ser Ala Leu Thr Gly Arg 
                325                 330                 335     


Glu Tyr His Leu Phe Asn Tyr Thr Gly Ala Ala Asp Ala Glu Arg Val 
            340                 345                 350         


Ile Ile Ala Met Gly Ser Val Cys Asp Thr Val Gln Glu Val Val Asp 
        355                 360                 365             


Thr Leu Asn Ala Ala Gly Glu Lys Val Gly Leu Leu Ser Val His Leu 
    370                 375                 380                 


Phe Arg Pro Phe Ser Leu Ala His Phe Phe Ala Gln Leu Pro Lys Thr 
385                 390                 395                 400 


Val Gln Arg Ile Ala Val Leu Asp Arg Thr Lys Glu Pro Gly Ala Gln 
                405                 410                 415     


Ala Glu Pro Leu Cys Leu Asp Val Lys Asn Ala Phe Tyr His His Asp 
            420                 425                 430         


Asp Ala Pro Leu Ile Val Gly Gly Arg Tyr Ala Leu Gly Gly Lys Asp 
        435                 440                 445             


Val Leu Pro Asn Asp Ile Ala Ala Val Phe Asp Asn Leu Asn Lys Pro 
    450                 455                 460                 


Leu Pro Met Asp Gly Phe Thr Leu Gly Ile Val Asp Asp Val Thr Phe 
465                 470                 475                 480 


Thr Ser Leu Pro Pro Arg Gln Gln Thr Leu Ala Val Ser His Asp Gly 
                485                 490                 495     


Ile Thr Ala Cys Lys Phe Trp Gly Met Gly Ser Asp Gly Thr Val Gly 
            500                 505                 510         


Ala Asn Lys Ser Ala Ile Lys Ile Ile Gly Asp Lys Thr Pro Leu Tyr 
        515                 520                 525             


Ala Gln Ala Tyr Phe Ser Tyr Asp Ser Lys Lys Ser Gly Gly Ile Thr 
    530                 535                 540                 


Val Ser His Leu Arg Phe Gly Asp Arg Pro Ile Asn Ser Pro Tyr Leu 
545                 550                 555                 560 


Ile His Arg Ala Asp Phe Ile Ser Cys Ser Gln Gln Ser Tyr Val Glu 
                565                 570                 575     


Arg Tyr Asp Leu Leu Asp Gly Leu Lys Pro Gly Gly Thr Phe Leu Leu 
            580                 585                 590         


Asn Cys Ser Trp Ser Asp Ala Glu Leu Glu Gln His Leu Pro Val Gly 
        595                 600                 605             


Phe Lys Arg Tyr Leu Ala Arg Glu Asn Ile His Phe Tyr Thr Leu Asn 
    610                 615                 620                 


Ala Val Asp Ile Ala Arg Glu Leu Gly Leu Gly Gly Arg Phe Asn Met 
625                 630                 635                 640 


Leu Met Gln Ala Ala Phe Phe Lys Leu Ala Ala Ile Ile Asp Pro Gln 
                645                 650                 655     


Thr Ala Ala Asp Tyr Leu Lys Gln Ala Val Glu Lys Ser Tyr Gly Ser 
            660                 665                 670         


Lys Gly Ala Ala Val Ile Glu Met Asn Gln Arg Ala Ile Glu Leu Gly 
        675                 680                 685             


Met Ala Ser Leu His Gln Val Thr Ile Pro Ala His Trp Ala Thr Leu 
    690                 695                 700                 


Asp Glu Pro Ala Ala Gln Ala Ser Ala Met Met Pro Asp Phe Ile Arg 
705                 710                 715                 720 


Asp Ile Leu Gln Pro Met Asn Arg Gln Cys Gly Asp Gln Leu Pro Val 
                725                 730                 735     


Ser Ala Phe Val Gly Met Glu Asp Gly Thr Phe Pro Ser Gly Thr Ala 
            740                 745                 750         


Ala Trp Glu Lys Arg Gly Ile Ala Leu Glu Val Pro Val Trp Gln Pro 
        755                 760                 765             


Glu Gly Cys Thr Gln Cys Asn Gln Cys Ala Phe Ile Cys Pro His Ala 
    770                 775                 780                 


Ala Ile Arg Pro Ala Leu Leu Asn Gly Glu Glu His Asp Ala Ala Pro 
785                 790                 795                 800 


Val Gly Leu Leu Ser Lys Pro Ala Gln Gly Ala Lys Glu Tyr His Tyr 
                805                 810                 815     


His Leu Ala Ile Ser Pro Leu Asp Cys Ser Gly Cys Gly Asn Cys Val 
            820                 825                 830         


Asp Ile Cys Pro Ala Arg Gly Lys Ala Leu Lys Met Gln Ser Leu Asp 
        835                 840                 845             


Ser Gln Arg Gln Met Ala Pro Val Trp Asp Tyr Ala Leu Ala Leu Thr 
    850                 855                 860                 


Pro Lys Ser Asn Pro Phe Arg Lys Thr Thr Val Lys Gly Ser Gln Phe 
865                 870                 875                 880 


Glu Thr Pro Leu Leu Glu Phe Ser Gly Ala Cys Ala Gly Cys Gly Glu 
                885                 890                 895     


Thr Pro Tyr Ala Arg Leu Ile Thr Gln Leu Phe Gly Asp Arg Met Leu 
            900                 905                 910         


Ile Ala Asn Ala Thr Gly Cys Ser Ser Ile Trp Gly Ala Ser Ala Pro 
        915                 920                 925             


Ser Ile Pro Tyr Thr Thr Asn His Arg Gly His Gly Pro Ala Trp Ala 
    930                 935                 940                 


Asn Ser Leu Phe Glu Asp Asn Ala Glu Phe Gly Leu Gly Met Met Leu 
945                 950                 955                 960 


Gly Gly Gln Ala Val Arg Gln Gln Ile Ala Asp Asp Met Thr Ala Ala 
                965                 970                 975     


Leu Ala Leu Pro Val Ser Asp Glu Leu Ser Asp Ala Met Arg Gln Trp 
            980                 985                 990         


Leu Ala Lys Gln Asp Glu Gly Glu  Gly Thr Arg Glu Arg  Ala Asp Arg 
        995                 1000                 1005             


Leu Ser  Glu Arg Leu Ala Ala  Glu Lys Glu Gly Val  Pro Leu Leu 
    1010                 1015                 1020             


Glu Gln  Leu Trp Gln Asn Arg  Asp Tyr Phe Val Arg  Arg Ser Gln 
    1025                 1030                 1035             


Trp Ile  Phe Gly Gly Asp Gly  Trp Ala Tyr Asp Ile  Gly Phe Gly 
    1040                 1045                 1050             


Gly Leu  Asp His Val Leu Ala  Ser Gly Glu Asp Val  Asn Ile Leu 
    1055                 1060                 1065             


Val Phe  Asp Thr Glu Val Tyr  Ser Asn Thr Gly Gly  Gln Ser Ser 
    1070                 1075                 1080             


Lys Ser  Thr Pro Val Ala Ala  Ile Ala Lys Phe Ala  Ala Gln Gly 
    1085                 1090                 1095             


Lys Arg  Thr Arg Lys Lys Asp  Leu Gly Met Met Ala  Met Ser Tyr 
    1100                 1105                 1110             


Gly Asn  Val Tyr Val Ala Gln  Val Ala Met Gly Ala  Asp Lys Asp 
    1115                 1120                 1125             


Gln Thr  Leu Arg Ala Ile Ala  Glu Ala Glu Ala Trp  Pro Gly Pro 
    1130                 1135                 1140             


Ser Leu  Val Ile Ala Tyr Ala  Ala Cys Ile Asn His  Gly Leu Lys 
    1145                 1150                 1155             


Ala Gly  Met Arg Cys Ser Gln  Arg Glu Ala Lys Arg  Ala Val Glu 
    1160                 1165                 1170             


Ala Gly  Tyr Trp His Leu Trp  Arg Tyr His Pro Gln  Arg Glu Ala 
    1175                 1180                 1185             


Glu Gly  Lys Thr Pro Phe Met  Leu Asp Ser Glu Glu  Pro Glu Glu 
    1190                 1195                 1200             


Ser Phe  Arg Asp Phe Leu Leu  Gly Glu Val Arg Tyr  Ala Ser Leu 
    1205                 1210                 1215             


His Lys  Thr Thr Pro His Leu  Ala Asp Ala Leu Phe  Ser Arg Thr 
    1220                 1225                 1230             


Glu Glu  Asp Ala Arg Ala Arg  Phe Ala Gln Tyr Arg  Arg Leu Ala 
    1235                 1240                 1245             


Gly Glu  Glu Asp Tyr Lys Asp  Asp Asp Asp Lys Pro  Gly 
    1250                 1255                 1260     


<210>  50
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  50

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Ser Gln Thr Ile Asp Lys Ile Asn Ser Cys Tyr Pro Leu Phe Glu Gln 
                85                  90                  95      


Asp Glu Tyr Gln Glu Leu Phe Arg Asn Lys Arg Gln Leu Glu Glu Ala 
            100                 105                 110         


His Asp Ala Gln Arg Val Gln Glu Val Phe Ala Trp Thr Thr Thr Ala 
        115                 120                 125             


Glu Tyr Glu Ala Leu Asn Phe Arg Arg Glu Ala Leu Thr Val Asp Pro 
    130                 135                 140                 


Ala Lys Ala Cys Gln Pro Leu Gly Ala Val Leu Cys Ser Leu Gly Phe 
145                 150                 155                 160 


Ala Asn Thr Leu Pro Tyr Val His Gly Ser Gln Gly Cys Val Ala Tyr 
                165                 170                 175     


Phe Arg Thr Tyr Phe Asn Arg His Phe Lys Glu Pro Ile Ala Cys Val 
            180                 185                 190         


Ser Asp Ser Met Thr Glu Asp Ala Ala Val Phe Gly Gly Asn Asn Asn 
        195                 200                 205             


Met Asn Leu Gly Leu Gln Asn Ala Ser Ala Leu Tyr Lys Pro Glu Ile 
    210                 215                 220                 


Ile Ala Val Ser Thr Thr Cys Met Ala Glu Val Ile Gly Asp Asp Leu 
225                 230                 235                 240 


Gln Ala Phe Ile Ala Asn Ala Lys Lys Asp Gly Phe Val Asp Ser Ser 
                245                 250                 255     


Ile Ala Val Pro His Ala His Thr Pro Ser Phe Ile Gly Ser His Val 
            260                 265                 270         


Thr Gly Trp Asp Asn Met Phe Glu Gly Phe Ala Lys Thr Phe Thr Ala 
        275                 280                 285             


Asp Tyr Gln Gly Gln Pro Gly Lys Leu Pro Lys Leu Asn Leu Val Thr 
    290                 295                 300                 


Gly Phe Glu Thr Tyr Leu Gly Asn Phe Arg Val Leu Lys Arg Met Met 
305                 310                 315                 320 


Glu Gln Met Ala Val Pro Cys Ser Leu Leu Ser Asp Pro Ser Glu Val 
                325                 330                 335     


Leu Asp Thr Pro Ala Asp Gly His Tyr Arg Met Tyr Ser Gly Gly Thr 
            340                 345                 350         


Thr Gln Gln Glu Met Lys Glu Ala Pro Asp Ala Ile Asp Thr Leu Leu 
        355                 360                 365             


Leu Gln Pro Trp Gln Leu Leu Lys Ser Lys Lys Val Val Gln Glu Met 
    370                 375                 380                 


Trp Asn Gln Pro Ala Thr Glu Val Ala Ile Pro Leu Gly Leu Ala Ala 
385                 390                 395                 400 


Thr Asp Glu Leu Leu Met Thr Val Ser Gln Leu Ser Gly Lys Pro Ile 
                405                 410                 415     


Ala Asp Ala Leu Thr Leu Glu Arg Gly Arg Leu Val Asp Met Met Leu 
            420                 425                 430         


Asp Ser His Thr Trp Leu His Gly Lys Lys Phe Gly Leu Tyr Gly Asp 
        435                 440                 445             


Pro Asp Phe Val Met Gly Leu Thr Arg Phe Leu Leu Glu Leu Gly Cys 
    450                 455                 460                 


Glu Pro Thr Val Ile Leu Ser His Asn Ala Asn Lys Arg Trp Gln Lys 
465                 470                 475                 480 


Ala Met Asn Lys Met Leu Asp Ala Ser Pro Tyr Gly Arg Asp Ser Glu 
                485                 490                 495     


Val Phe Ile Asn Cys Asp Leu Trp His Phe Arg Ser Leu Met Phe Thr 
            500                 505                 510         


Arg Gln Pro Asp Phe Met Ile Gly Asn Ser Tyr Gly Lys Phe Ile Gln 
        515                 520                 525             


Arg Asp Thr Leu Ala Lys Gly Lys Ala Phe Glu Val Pro Leu Ile Arg 
    530                 535                 540                 


Leu Gly Phe Pro Leu Phe Asp Arg His His Leu His Arg Gln Thr Thr 
545                 550                 555                 560 


Trp Gly Tyr Glu Gly Ala Met Asn Ile Val Thr Thr Leu Val Asn Ala 
                565                 570                 575     


Val Leu Glu Lys Leu Asp Ser Asp Thr Ser Gln Leu Gly Lys Thr Asp 
            580                 585                 590         


Tyr Ser Phe Asp Leu Val Arg Ala Gly Gly Gly Gly Gly Tyr Pro Tyr 
        595                 600                 605             


Asp Val Pro Asp Tyr Ala Pro Gly 
    610                 615     


<210>  51
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  51

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Met Asn Pro Trp Gln Arg Phe Ala Arg Gln Arg Leu Ala Arg Ser Arg 
                85                  90                  95      


Trp Asn Arg Asp Pro Ala Ala Leu Asp Pro Ala Asp Thr Pro Ala Phe 
            100                 105                 110         


Glu Gln Ala Trp Gln Arg Gln Cys His Met Glu Gln Thr Ile Val Ala 
        115                 120                 125             


Arg Val Pro Glu Gly Asp Ile Pro Ala Ala Leu Leu Glu Asn Ile Ala 
    130                 135                 140                 


Ala Ser Leu Ala Ile Trp Leu Asp Glu Gly Asp Phe Ala Pro Pro Glu 
145                 150                 155                 160 


Arg Ala Ala Ile Val Arg His His Ala Arg Leu Glu Leu Ala Phe Ala 
                165                 170                 175     


Asp Ile Ala Arg Gln Ala Pro Gln Pro Asp Leu Ser Thr Val Gln Ala 
            180                 185                 190         


Trp Tyr Leu Arg His Gln Thr Gln Phe Met Arg Pro Glu Gln Arg Leu 
        195                 200                 205             


Thr Arg His Leu Leu Leu Thr Val Asp Asn Asp Arg Glu Ala Val His 
    210                 215                 220                 


Gln Arg Ile Leu Gly Leu Tyr Arg Gln Ile Asn Ala Ser Arg Asp Ala 
225                 230                 235                 240 


Phe Ala Pro Leu Ala Gln Arg His Ser His Cys Pro Ser Ala Leu Glu 
                245                 250                 255     


Glu Gly Arg Leu Gly Trp Ile Ser Arg Gly Leu Leu Tyr Pro Gln Leu 
            260                 265                 270         


Glu Thr Ala Leu Phe Ser Leu Ala Glu Asn Ala Leu Ser Leu Pro Ile 
        275                 280                 285             


Ala Ser Glu Leu Gly Trp His Leu Leu Trp Cys Glu Ala Ile Arg Pro 
    290                 295                 300                 


Ala Ala Pro Met Glu Pro Gln Gln Ala Leu Glu Ser Ala Arg Asp Tyr 
305                 310                 315                 320 


Leu Trp Gln Gln Ser Gln Gln Arg His Gln Arg Gln Trp Leu Glu Gln 
                325                 330                 335     


Met Ile Ser Arg Gln Pro Gly Leu Cys Gly Tyr Pro Tyr Asp Val Pro 
            340                 345                 350         


Asp Tyr Ala Pro Gly 
        355         


<210>  52
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  52

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Ala Asp Ile Phe Arg Thr Asp Lys Pro Leu Ala Val Ser Pro Ile Lys 
                85                  90                  95      


Thr Gly Gln Pro Leu Gly Ala Ile Leu Ala Ser Leu Gly Ile Glu His 
            100                 105                 110         


Ser Ile Pro Leu Val His Gly Ala Gln Gly Cys Ser Ala Phe Ala Lys 
        115                 120                 125             


Val Phe Phe Ile Gln His Phe His Asp Pro Val Pro Leu Gln Ser Thr 
    130                 135                 140                 


Ala Met Asp Pro Thr Ser Thr Ile Met Gly Ala Asp Gly Asn Ile Phe 
145                 150                 155                 160 


Thr Ala Leu Asp Thr Leu Cys Gln Arg Asn Asn Pro Gln Ala Ile Val 
                165                 170                 175     


Leu Leu Ser Thr Gly Leu Ser Glu Ala Gln Gly Ser Asp Ile Ser Arg 
            180                 185                 190         


Val Val Arg Gln Phe Arg Glu Glu Tyr Pro Arg His Lys Gly Val Ala 
        195                 200                 205             


Ile Leu Thr Val Asn Thr Pro Asp Phe Tyr Gly Ser Met Glu Asn Gly 
    210                 215                 220                 


Phe Ser Ala Val Leu Glu Ser Val Ile Glu Gln Trp Val Pro Pro Ala 
225                 230                 235                 240 


Pro Arg Pro Ala Gln Arg Asn Arg Arg Val Asn Leu Leu Val Ser His 
                245                 250                 255     


Leu Cys Ser Pro Gly Asp Ile Glu Trp Leu Arg Arg Cys Val Glu Ala 
            260                 265                 270         


Phe Gly Leu Gln Pro Ile Ile Leu Pro Asp Leu Ala Gln Ser Met Asp 
        275                 280                 285             


Gly His Leu Ala Gln Gly Asp Phe Ser Pro Leu Thr Gln Gly Gly Thr 
    290                 295                 300                 


Pro Leu Arg Gln Ile Glu Gln Met Gly Gln Ser Leu Cys Ser Phe Ala 
305                 310                 315                 320 


Ile Gly Val Ser Leu His Arg Ala Ser Ser Leu Leu Ala Pro Arg Cys 
                325                 330                 335     


Arg Gly Glu Val Ile Ala Leu Pro His Leu Met Thr Leu Glu Arg Cys 
            340                 345                 350         


Asp Ala Phe Ile His Gln Leu Ala Lys Ile Ser Gly Arg Ala Val Pro 
        355                 360                 365             


Glu Trp Leu Glu Arg Gln Arg Gly Gln Leu Gln Asp Ala Met Ile Asp 
    370                 375                 380                 


Cys His Met Trp Leu Gln Gly Gln Arg Met Ala Ile Ala Ala Glu Gly 
385                 390                 395                 400 


Asp Leu Leu Ala Ala Trp Cys Asp Phe Ala Asn Ser Gln Gly Met Gln 
                405                 410                 415     


Pro Gly Pro Leu Val Ala Pro Thr Gly His Pro Ser Leu Arg Gln Leu 
            420                 425                 430         


Pro Val Glu Arg Val Val Pro Gly Asp Leu Glu Asp Leu Gln Thr Leu 
        435                 440                 445             


Leu Cys Ala His Pro Ala Asp Leu Leu Val Ala Asn Ser His Ala Arg 
    450                 455                 460                 


Asp Leu Ala Glu Gln Phe Ala Leu Pro Leu Val Arg Ala Gly Phe Pro 
465                 470                 475                 480 


Leu Phe Asp Lys Leu Gly Glu Phe Arg Arg Val Arg Gln Gly Tyr Ser 
                485                 490                 495     


Gly Met Arg Asp Thr Leu Phe Glu Leu Ala Asn Leu Ile Arg Glu Arg 
            500                 505                 510         


His His His Leu Ala His Tyr Arg Ser Pro Leu Arg Gln Asn Pro Glu 
        515                 520                 525             


Ser Ser Leu Ser Thr Gly Gly Ala Tyr Ala Ala Ala Gly Asp Tyr Lys 
    530                 535                 540                 


Asp Asp Asp Asp Lys Pro Gly 
545                 550     


<210>  53
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  53

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Pro Pro Leu Asp Trp Leu Arg Arg Leu Trp Leu Leu Tyr His Ala Gly 
                85                  90                  95      


Lys Gly Ser Phe Pro Leu Arg Met Gly Leu Ser Pro Arg Asp Trp Gln 
            100                 105                 110         


Ala Leu Arg Arg Arg Leu Gly Glu Val Glu Thr Pro Leu Asp Gly Glu 
        115                 120                 125             


Thr Leu Thr Arg Arg Arg Leu Met Ala Glu Leu Asn Ala Thr Arg Glu 
    130                 135                 140                 


Glu Glu Arg Gln Gln Leu Gly Ala Trp Leu Ala Gly Trp Met Gln Gln 
145                 150                 155                 160 


Asp Ala Gly Pro Met Ala Gln Ile Ile Ala Glu Val Ser Leu Ala Phe 
                165                 170                 175     


Asn His Leu Trp Gln Asp Leu Gly Leu Ala Ser Arg Ala Glu Leu Arg 
            180                 185                 190         


Leu Leu Met Ser Asp Cys Phe Pro Gln Leu Val Val Met Asn Glu His 
        195                 200                 205             


Asn Met Arg Trp Lys Lys Phe Phe Tyr Arg Gln Arg Cys Leu Leu Gln 
    210                 215                 220                 


Gln Gly Glu Val Ile Cys Arg Ser Pro Ser Cys Asp Glu Cys Trp Glu 
225                 230                 235                 240 


Arg Ser Ala Cys Phe Glu Ala Gly Gly Gly Gly Gly Tyr Pro Tyr Asp 
                245                 250                 255     


Val Pro Asp Tyr Ala Pro Gly 
            260             


<210>  54
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  54

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Lys Gln Val Tyr Leu Asp Asn Asn Ala Thr Thr Arg Leu Asp Pro Met 
                85                  90                  95      


Val Leu Glu Ala Met Met Pro Phe Leu Thr Asp Phe Tyr Gly Asn Pro 
            100                 105                 110         


Ser Ser Ile His Asp Phe Gly Ile Pro Ala Gln Ala Ala Leu Glu Arg 
        115                 120                 125             


Ala His Gln Gln Ala Ala Ala Leu Leu Gly Ala Glu Tyr Pro Ser Glu 
    130                 135                 140                 


Ile Ile Phe Thr Ser Cys Ala Thr Glu Ala Thr Ala Thr Ala Ile Ala 
145                 150                 155                 160 


Ser Ala Ile Ala Leu Leu Pro Glu Arg Arg Glu Ile Ile Thr Ser Val 
                165                 170                 175     


Val Glu His Pro Ala Thr Leu Ala Ala Cys Glu His Met Glu Arg Glu 
            180                 185                 190         


Gly Tyr Arg Ile His Arg Ile Ala Val Asp Gly Glu Gly Ala Leu Asp 
        195                 200                 205             


Met Ala Gln Phe Arg Ala Ala Leu Ser Pro Arg Val Ala Leu Val Ser 
    210                 215                 220                 


Val Met Trp Ala Asn Asn Glu Thr Gly Val Leu Phe Pro Ile Gly Glu 
225                 230                 235                 240 


Met Ala Glu Leu Ala His Glu Gln Gly Ala Leu Phe His Cys Asp Ala 
                245                 250                 255     


Val Gln Val Val Gly Lys Ile Pro Ile Ala Val Gly Gln Thr Arg Ile 
            260                 265                 270         


Asp Met Leu Ser Cys Ser Ala His Lys Phe His Gly Pro Lys Gly Val 
        275                 280                 285             


Gly Cys Leu Tyr Leu Arg Arg Gly Thr Arg Phe Arg Pro Leu Leu Arg 
    290                 295                 300                 


Gly Gly His Gln Glu Tyr Gly Arg Arg Ala Gly Thr Glu Asn Ile Cys 
305                 310                 315                 320 


Gly Ile Val Gly Met Gly Ala Ala Cys Glu Leu Ala Asn Ile His Leu 
                325                 330                 335     


Pro Gly Met Thr His Ile Gly Gln Leu Arg Asn Arg Leu Glu His Arg 
            340                 345                 350         


Leu Leu Ala Ser Val Pro Ser Val Met Val Met Gly Gly Gly Gln Pro 
        355                 360                 365             


Ala Val Pro Gly Thr Val Asn Leu Ala Phe Glu Phe Ile Glu Gly Glu 
    370                 375                 380                 


Ala Ile Leu Leu Leu Leu Asn Gln Ala Gly Ile Ala Ala Ser Ser Gly 
385                 390                 395                 400 


Ser Ala Cys Thr Ser Gly Ser Leu Glu Pro Ser His Val Met Arg Ala 
                405                 410                 415     


Met Asn Ile Pro Tyr Thr Ala Ala His Gly Thr Ile Arg Phe Ser Leu 
            420                 425                 430         


Ser Arg Tyr Thr Arg Glu Lys Glu Ile Asp Tyr Val Val Ala Thr Leu 
        435                 440                 445             


Pro Pro Ile Ile Asp Arg Leu Arg Ala Leu Ser Pro Tyr Trp Gln Asn 
    450                 455                 460                 


Gly Lys Pro Arg Pro Ala Asp Ala Val Phe Thr Pro Val Tyr Gly Ala 
465                 470                 475                 480 


Gly Gly Gly Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
                485                 490                 495     


<210>  55
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  55

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Trp Asn Tyr Ser Glu Lys Val Lys Asp His Phe Phe Asn Pro Arg Asn 
                85                  90                  95      


Ala Arg Val Val Asp Asn Ala Asn Ala Val Gly Asp Val Gly Ser Leu 
            100                 105                 110         


Ser Cys Gly Asp Ala Leu Arg Leu Met Leu Arg Val Asp Pro Gln Ser 
        115                 120                 125             


Glu Ile Ile Glu Glu Ala Gly Phe Gln Thr Phe Gly Cys Gly Ser Ala 
    130                 135                 140                 


Ile Ala Ser Ser Ser Ala Leu Thr Glu Leu Ile Ile Gly His Thr Leu 
145                 150                 155                 160 


Ala Glu Ala Gly Gln Ile Thr Asn Gln Gln Ile Ala Asp Tyr Leu Asp 
                165                 170                 175     


Gly Leu Pro Pro Glu Lys Met His Cys Ser Val Met Gly Gln Glu Ala 
            180                 185                 190         


Leu Arg Ala Ala Ile Ala Asn Phe Arg Gly Glu Ser Leu Glu Glu Glu 
        195                 200                 205             


His Asp Glu Gly Lys Leu Ile Cys Lys Cys Phe Gly Val Asp Glu Gly 
    210                 215                 220                 


His Ile Arg Arg Ala Val Gln Asn Asn Gly Leu Thr Thr Leu Ala Glu 
225                 230                 235                 240 


Val Ile Asn Tyr Thr Lys Ala Gly Gly Gly Cys Thr Ser Cys His Glu 
                245                 250                 255     


Lys Ile Glu Leu Ala Leu Ala Glu Ile Leu Ala Gln Gln Pro Gln Thr 
            260                 265                 270         


Thr Pro Ala Val Ala Ser Gly Lys Asp Pro His Trp Gln Ser Val Val 
        275                 280                 285             


Asp Thr Ile Ala Glu Leu Arg Pro His Ile Gln Ala Asp Gly Gly Asp 
    290                 295                 300                 


Met Ala Leu Leu Ser Val Thr Asn His Gln Val Thr Val Ser Leu Ser 
305                 310                 315                 320 


Gly Ser Cys Ser Gly Cys Met Met Thr Asp Met Thr Leu Ala Trp Leu 
                325                 330                 335     


Gln Gln Lys Leu Met Glu Arg Thr Gly Cys Tyr Met Glu Val Val Ala 
            340                 345                 350         


Ala Ala Gly Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
        355                 360                 365 


<210>  56
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  56

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Met Glu Arg Val Leu Ile Asn Asp Thr Thr Leu Arg Asp Gly Glu Gln 
                85                  90                  95      


Ser Pro Gly Val Ala Phe Arg Thr Ser Glu Lys Val Ala Ile Ala Glu 
            100                 105                 110         


Ala Leu Tyr Ala Ala Gly Ile Thr Ala Met Glu Val Gly Thr Pro Ala 
        115                 120                 125             


Met Gly Asp Glu Glu Ile Ala Arg Ile Gln Leu Val Arg Arg Gln Leu 
    130                 135                 140                 


Pro Asp Ala Thr Leu Met Thr Trp Cys Arg Met Asn Ala Leu Glu Ile 
145                 150                 155                 160 


Arg Gln Ser Ala Asp Leu Gly Ile Asp Trp Val Asp Ile Ser Ile Pro 
                165                 170                 175     


Ala Ser Asp Lys Leu Arg Gln Tyr Lys Leu Arg Glu Pro Leu Ala Val 
            180                 185                 190         


Leu Leu Glu Arg Leu Ala Met Phe Ile His Leu Ala His Thr Leu Gly 
        195                 200                 205             


Leu Lys Val Cys Ile Gly Cys Glu Asp Ala Ser Arg Ala Ser Gly Gln 
    210                 215                 220                 


Thr Leu Arg Ala Ile Ala Glu Val Ala Gln Asn Ala Pro Ala Ala Arg 
225                 230                 235                 240 


Leu Arg Tyr Ala Asp Thr Val Gly Leu Leu Asp Pro Phe Thr Thr Ala 
                245                 250                 255     


Ala Gln Ile Ser Ala Leu Arg Asp Val Trp Ser Gly Glu Ile Glu Met 
            260                 265                 270         


His Ala His Asn Asp Leu Gly Met Ala Thr Ala Asn Thr Leu Ala Ala 
        275                 280                 285             


Val Ser Ala Gly Ala Thr Ser Val Asn Thr Thr Val Leu Gly Leu Gly 
    290                 295                 300                 


Glu Arg Ala Gly Asn Ala Ala Ala Trp Lys Pro Ser Ala Leu Gly Leu 
305                 310                 315                 320 


Glu Arg Cys Leu Gly Val Glu Thr Gly Val His Phe Ser Ala Leu Pro 
                325                 330                 335     


Ala Leu Cys Gln Arg Val Ala Glu Ala Ala Gln Arg Ala Ile Asp Pro 
            340                 345                 350         


Gln Gln Pro Leu Val Gly Glu Leu Val Phe Thr His Glu Ser Gly Val 
        355                 360                 365             


His Val Ala Ala Leu Leu Arg Asp Ser Glu Ser Tyr Gln Ser Ile Ala 
    370                 375                 380                 


Pro Ser Leu Met Gly Arg Ser Tyr Arg Leu Val Leu Gly Lys His Ser 
385                 390                 395                 400 


Gly Arg Gln Ala Val Asn Gly Val Phe Asp Gln Met Gly Tyr His Leu 
                405                 410                 415     


Asn Ala Ala Gln Ile Asn Gln Leu Leu Pro Ala Ile Arg Arg Phe Ala 
            420                 425                 430         


Glu Asn Trp Lys Arg Ser Pro Lys Asp Tyr Glu Leu Val Ala Ile Tyr 
        435                 440                 445             


Asp Glu Leu Cys Gly Glu Ser Ala Leu Arg Ala Arg Gly Asp Tyr Lys 
    450                 455                 460                 


Asp Asp Asp Asp Lys Pro Gly 
465                 470     


<210>  57
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  57

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Pro Pro Ile Asn Arg Gln Phe Asp Met Val His Ser Asp Glu Trp Ser 
                85                  90                  95      


Met Lys Val Ala Phe Ala Ser Ser Asp Tyr Arg His Val Asp Gln His 
            100                 105                 110         


Phe Gly Ala Thr Pro Arg Leu Val Val Tyr Gly Val Lys Ala Asp Arg 
        115                 120                 125             


Val Thr Leu Ile Arg Val Val Asp Phe Ser Val Glu Asn Gly His Gln 
    130                 135                 140                 


Thr Glu Lys Ile Ala Arg Arg Ile His Ala Leu Glu Asp Cys Val Thr 
145                 150                 155                 160 


Leu Phe Cys Val Ala Ile Gly Asp Ala Val Phe Arg Gln Leu Leu Gln 
                165                 170                 175     


Val Gly Val Arg Ala Glu Arg Val Pro Ala Asp Thr Thr Ile Val Gly 
            180                 185                 190         


Leu Leu Gln Glu Ile Gln Leu Tyr Trp Tyr Asp Lys Gly Gln Arg Lys 
        195                 200                 205             


Asn Gln Arg Gln Arg Asp Pro Glu Arg Phe Thr Arg Leu Leu Gln Glu 
    210                 215                 220                 


Gln Glu Trp His Gly Asp Pro Asp Pro Arg Arg Ala Gly Asp Tyr Lys 
225                 230                 235                 240 


Asp Asp Asp Asp Lys Pro Gly 
                245         


<210>  58
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  58

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Ser Asp Asn Asp Thr Leu Phe Trp Arg Met Leu Ala Leu Phe Gln Ser 
                85                  90                  95      


Leu Pro Asp Leu Gln Pro Ala Gln Ile Val Asp Trp Leu Ala Gln Glu 
            100                 105                 110         


Ser Gly Glu Thr Leu Thr Pro Glu Arg Leu Ala Thr Leu Thr Gln Pro 
        115                 120                 125             


Gln Leu Ala Ala Ser Phe Pro Ser Ala Thr Ala Val Met Ser Pro Ala 
    130                 135                 140                 


Arg Trp Ser Arg Val Met Ala Ser Leu Gln Gly Ala Leu Pro Ala His 
145                 150                 155                 160 


Leu Arg Ile Val Arg Pro Ala Gln Arg Thr Pro Gln Leu Leu Ala Ala 
                165                 170                 175     


Phe Cys Ser Gln Asp Gly Leu Val Ile Asn Gly His Phe Gly Gln Gly 
            180                 185                 190         


Arg Leu Phe Phe Ile Tyr Ala Phe Asp Glu Gln Gly Gly Trp Leu Tyr 
        195                 200                 205             


Asp Leu Arg Arg Tyr Pro Ser Ala Pro His Gln Gln Glu Ala Asn Glu 
    210                 215                 220                 


Val Arg Ala Arg Leu Ile Glu Asp Cys Gln Leu Leu Phe Cys Gln Glu 
225                 230                 235                 240 


Ile Gly Gly Pro Ala Ala Ala Arg Pro Ile Arg His Arg Ile His Pro 
                245                 250                 255     


Met Lys Ala Gln Pro Gly Thr Thr Ile Gln Ala Gln Cys Glu Ala Ile 
            260                 265                 270         


Asn Thr Leu Leu Ala Gly Arg Leu Pro Pro Trp Leu Ala Lys Arg Leu 
        275                 280                 285             


Asn Arg Asp Asn Pro Leu Glu Glu Arg Val Phe Ala Gly Gly Gly Gly 
    290                 295                 300                 


Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
305                 310                 315     


<210>  59
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  59

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Thr Asn Ala Thr Gly Glu Arg Asn Leu Ala Leu Ile Gln Glu Val Leu 
                85                  90                  95      


Glu Val Phe Pro Glu Thr Ala Arg Lys Glu Arg Arg Lys His Met Met 
            100                 105                 110         


Val Ser Asp Pro Lys Met Lys Ser Val Gly Lys Cys Ile Ile Ser Asn 
        115                 120                 125             


Arg Lys Ser Gln Pro Gly Val Met Thr Val Arg Gly Cys Ala Tyr Ala 
    130                 135                 140                 


Gly Ser Lys Gly Val Val Phe Gly Pro Ile Lys Asp Met Ala His Ile 
145                 150                 155                 160 


Ser His Gly Pro Ala Gly Cys Gly Gln Tyr Ser Arg Ala Glu Arg Arg 
                165                 170                 175     


Asn Tyr Tyr Thr Gly Val Ser Gly Val Asp Ser Phe Gly Thr Leu Asn 
            180                 185                 190         


Phe Thr Ser Asp Phe Gln Glu Arg Asp Ile Val Phe Gly Gly Asp Lys 
        195                 200                 205             


Lys Leu Ser Lys Leu Ile Glu Glu Met Glu Leu Leu Phe Pro Leu Thr 
    210                 215                 220                 


Lys Gly Ile Thr Ile Gln Ser Glu Cys Pro Val Gly Leu Ile Gly Asp 
225                 230                 235                 240 


Asp Ile Ser Ala Val Ala Asn Ala Ser Ser Lys Ala Leu Asp Lys Pro 
                245                 250                 255     


Val Ile Pro Val Arg Cys Glu Gly Phe Arg Gly Val Ser Gln Ser Leu 
            260                 265                 270         


Gly His His Ile Ala Asn Asp Val Val Arg Asp Trp Ile Leu Asn Asn 
        275                 280                 285             


Arg Glu Gly Gln Pro Phe Glu Thr Thr Pro Tyr Asp Val Ala Ile Ile 
    290                 295                 300                 


Gly Asp Tyr Asn Ile Gly Gly Asp Ala Trp Ala Ser Arg Ile Leu Leu 
305                 310                 315                 320 


Glu Glu Met Gly Leu Arg Val Val Ala Gln Trp Ser Gly Asp Gly Thr 
                325                 330                 335     


Leu Val Glu Met Glu Asn Thr Pro Phe Val Lys Leu Asn Leu Val His 
            340                 345                 350         


Cys Tyr Arg Ser Met Asn Tyr Ile Ala Arg His Met Glu Glu Lys His 
        355                 360                 365             


Gln Ile Pro Trp Met Glu Tyr Asn Phe Phe Gly Pro Thr Lys Ile Ala 
    370                 375                 380                 


Glu Ser Leu Arg Lys Ile Ala Asp Gln Phe Asp Asp Thr Ile Arg Ala 
385                 390                 395                 400 


Asn Ala Glu Ala Val Ile Ala Arg Tyr Glu Gly Gln Met Ala Ala Ile 
                405                 410                 415     


Ile Ala Lys Tyr Arg Pro Arg Leu Glu Gly Arg Lys Val Leu Leu Tyr 
            420                 425                 430         


Ile Gly Gly Leu Arg Pro Arg His Val Ile Gly Ala Tyr Glu Asp Leu 
        435                 440                 445             


Gly Met Glu Ile Ile Ala Ala Gly Tyr Glu Phe Ala His Asn Asp Asp 
    450                 455                 460                 


Tyr Asp Arg Thr Leu Pro Asp Leu Lys Glu Gly Thr Leu Leu Phe Asp 
465                 470                 475                 480 


Asp Ala Ser Ser Tyr Glu Leu Glu Ala Phe Val Lys Ala Leu Lys Pro 
                485                 490                 495     


Asp Leu Ile Gly Ser Gly Ile Lys Glu Lys Tyr Ile Phe Gln Lys Met 
            500                 505                 510         


Gly Val Pro Phe Arg Gln Met His Ser Trp Asp Tyr Ser Gly Pro Tyr 
        515                 520                 525             


His Gly Tyr Asp Gly Phe Ala Ile Phe Ala Arg Asp Met Asp Met Thr 
    530                 535                 540                 


Leu Asn Asn Pro Ala Trp Asn Glu Leu Thr Ala Pro Trp Leu Lys Ser 
545                 550                 555                 560 


Ala Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
                565                 570                 


<210>  60
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  60

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Ser Gln Thr Ile Asp Lys Ile Asn Ser Cys Tyr Pro Leu Phe Glu Gln 
                85                  90                  95      


Asp Glu Tyr Gln Glu Leu Phe Arg Asn Lys Arg Gln Leu Glu Glu Ala 
            100                 105                 110         


His Asp Ala Gln Arg Val Gln Glu Val Phe Ala Trp Thr Thr Thr Ala 
        115                 120                 125             


Glu Tyr Glu Ala Leu Asn Phe Arg Arg Glu Ala Leu Thr Val Asp Pro 
    130                 135                 140                 


Ala Lys Ala Cys Gln Pro Leu Gly Ala Val Leu Cys Ser Leu Gly Phe 
145                 150                 155                 160 


Ala Asn Thr Leu Pro Tyr Val His Gly Ser Gln Gly Cys Val Ala Tyr 
                165                 170                 175     


Phe Arg Thr Tyr Phe Asn Arg His Phe Lys Glu Pro Ile Ala Cys Val 
            180                 185                 190         


Ser Asp Ser Met Thr Glu Asp Ala Ala Val Phe Gly Gly Asn Asn Asn 
        195                 200                 205             


Met Asn Leu Gly Leu Gln Asn Ala Ser Ala Leu Tyr Lys Pro Glu Ile 
    210                 215                 220                 


Ile Ala Val Ser Thr Thr Cys Met Ala Glu Val Ile Gly Asp Asp Leu 
225                 230                 235                 240 


Gln Ala Phe Ile Ala Asn Ala Lys Lys Asp Gly Phe Val Asp Ser Ser 
                245                 250                 255     


Ile Ala Val Pro His Ala His Thr Pro Ser Phe Ile Gly Ser His Val 
            260                 265                 270         


Thr Gly Trp Asp Asn Met Phe Glu Gly Phe Ala Lys Thr Phe Thr Ala 
        275                 280                 285             


Asp Tyr Gln Gly Gln Pro Gly Lys Leu Pro Lys Leu Asn Leu Val Thr 
    290                 295                 300                 


Gly Phe Glu Thr Tyr Leu Gly Asn Phe Arg Val Leu Lys Arg Met Met 
305                 310                 315                 320 


Glu Gln Met Ala Val Pro Cys Ser Leu Leu Ser Asp Pro Ser Glu Val 
                325                 330                 335     


Leu Asp Thr Pro Ala Asp Gly His Tyr Arg Met Tyr Ser Gly Gly Thr 
            340                 345                 350         


Thr Gln Gln Glu Met Lys Glu Ala Pro Asp Ala Ile Asp Thr Leu Leu 
        355                 360                 365             


Leu Gln Pro Trp Gln Leu Leu Lys Ser Lys Lys Val Val Gln Glu Met 
    370                 375                 380                 


Trp Asn Gln Pro Ala Thr Glu Val Ala Ile Pro Leu Gly Leu Ala Ala 
385                 390                 395                 400 


Thr Asp Glu Leu Leu Met Thr Val Ser Gln Leu Ser Gly Lys Pro Ile 
                405                 410                 415     


Ala Asp Ala Leu Thr Leu Glu Arg Gly Arg Leu Val Asp Met Met Leu 
            420                 425                 430         


Asp Ser His Thr Trp Leu His Gly Lys Lys Phe Gly Leu Tyr Gly Asp 
        435                 440                 445             


Pro Asp Phe Val Met Gly Leu Thr Arg Phe Leu Leu Glu Leu Gly Cys 
    450                 455                 460                 


Glu Pro Thr Val Ile Leu Ser His Asn Ala Asn Lys Arg Trp Gln Lys 
465                 470                 475                 480 


Ala Met Asn Lys Met Leu Asp Ala Ser Pro Tyr Gly Arg Asp Ser Glu 
                485                 490                 495     


Val Phe Ile Asn Cys Asp Leu Trp His Phe Arg Ser Leu Met Phe Thr 
            500                 505                 510         


Arg Gln Pro Asp Phe Met Ile Gly Asn Ser Tyr Gly Lys Phe Ile Gln 
        515                 520                 525             


Arg Asp Thr Leu Ala Lys Gly Lys Ala Phe Glu Val Pro Leu Ile Arg 
    530                 535                 540                 


Leu Gly Phe Pro Leu Phe Asp Arg His His Leu His Arg Gln Thr Thr 
545                 550                 555                 560 


Trp Gly Tyr Glu Gly Ala Met Asn Ile Val Thr Thr Leu Val Asn Ala 
                565                 570                 575     


Val Leu Glu Lys Leu Asp Ser Asp Thr Ser Gln Leu Gly Lys Thr Asp 
            580                 585                 590         


Tyr Ser Phe Asp Leu Val Arg 
        595                 


<210>  61
<211>  11
<212>  PRT
<213>  Hypocrea jecorina

<400>  61

Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Arg 
1               5                   10      


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG epitope

<400>  62

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  63
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  63

Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Ala Asp Tyr Lys Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Ala 
            20                  25                  30  


<210>  64
<211>  1110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  64

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Thr Asn Ala Thr Gly Glu Arg Asn Leu Ala Leu Ile Gln Glu Val Leu 
                85                  90                  95      


Glu Val Phe Pro Glu Thr Ala Arg Lys Glu Arg Arg Lys His Met Met 
            100                 105                 110         


Val Ser Asp Pro Lys Met Lys Ser Val Gly Lys Cys Ile Ile Ser Asn 
        115                 120                 125             


Arg Lys Ser Gln Pro Gly Val Met Thr Val Arg Gly Cys Ala Tyr Ala 
    130                 135                 140                 


Gly Ser Lys Gly Val Val Phe Gly Pro Ile Lys Asp Met Ala His Ile 
145                 150                 155                 160 


Ser His Gly Pro Ala Gly Cys Gly Gln Tyr Ser Arg Ala Glu Arg Arg 
                165                 170                 175     


Asn Tyr Tyr Thr Gly Val Ser Gly Val Asp Ser Phe Gly Thr Leu Asn 
            180                 185                 190         


Phe Thr Ser Asp Phe Gln Glu Arg Asp Ile Val Phe Gly Gly Asp Lys 
        195                 200                 205             


Lys Leu Ser Lys Leu Ile Glu Glu Met Glu Leu Leu Phe Pro Leu Thr 
    210                 215                 220                 


Lys Gly Ile Thr Ile Gln Ser Glu Cys Pro Val Gly Leu Ile Gly Asp 
225                 230                 235                 240 


Asp Ile Ser Ala Val Ala Asn Ala Ser Ser Lys Ala Leu Asp Lys Pro 
                245                 250                 255     


Val Ile Pro Val Arg Cys Glu Gly Phe Arg Gly Val Ser Gln Ser Leu 
            260                 265                 270         


Gly His His Ile Ala Asn Asp Val Val Arg Asp Trp Ile Leu Asn Asn 
        275                 280                 285             


Arg Glu Gly Gln Pro Phe Glu Thr Thr Pro Tyr Asp Val Ala Ile Ile 
    290                 295                 300                 


Gly Asp Tyr Asn Ile Gly Gly Asp Ala Trp Ala Ser Arg Ile Leu Leu 
305                 310                 315                 320 


Glu Glu Met Gly Leu Arg Val Val Ala Gln Trp Ser Gly Asp Gly Thr 
                325                 330                 335     


Leu Val Glu Met Glu Asn Thr Pro Phe Val Lys Leu Asn Leu Val His 
            340                 345                 350         


Cys Tyr Arg Ser Met Asn Tyr Ile Ala Arg His Met Glu Glu Lys His 
        355                 360                 365             


Gln Ile Pro Trp Met Glu Tyr Asn Phe Phe Gly Pro Thr Lys Ile Ala 
    370                 375                 380                 


Glu Ser Leu Arg Lys Ile Ala Asp Gln Phe Asp Asp Thr Ile Arg Ala 
385                 390                 395                 400 


Asn Ala Glu Ala Val Ile Ala Arg Tyr Glu Gly Gln Met Ala Ala Ile 
                405                 410                 415     


Ile Ala Lys Tyr Arg Pro Arg Leu Glu Gly Arg Lys Val Leu Leu Tyr 
            420                 425                 430         


Ile Gly Gly Leu Arg Pro Arg His Val Ile Gly Ala Tyr Glu Asp Leu 
        435                 440                 445             


Gly Met Glu Ile Ile Ala Ala Gly Tyr Glu Phe Ala His Asn Asp Asp 
    450                 455                 460                 


Tyr Asp Arg Thr Leu Pro Asp Leu Lys Glu Gly Thr Leu Leu Phe Asp 
465                 470                 475                 480 


Asp Ala Ser Ser Tyr Glu Leu Glu Ala Phe Val Lys Ala Leu Lys Pro 
                485                 490                 495     


Asp Leu Ile Gly Ser Gly Ile Lys Glu Lys Tyr Ile Phe Gln Lys Met 
            500                 505                 510         


Gly Val Pro Phe Arg Gln Met His Ser Trp Asp Tyr Ser Gly Pro Tyr 
        515                 520                 525             


His Gly Tyr Asp Gly Phe Ala Ile Phe Ala Arg Asp Met Asp Met Thr 
    530                 535                 540                 


Leu Asn Asn Pro Ala Trp Asn Glu Leu Thr Ala Pro Trp Leu Lys Ser 
545                 550                 555                 560 


Ala Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Ala Asp Tyr Lys Asp 
                565                 570                 575     


Asp Asp Asp Lys Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Ala Ser 
            580                 585                 590         


Gln Thr Ile Asp Lys Ile Asn Ser Cys Tyr Pro Leu Phe Glu Gln Asp 
        595                 600                 605             


Glu Tyr Gln Glu Leu Phe Arg Asn Lys Arg Gln Leu Glu Glu Ala His 
    610                 615                 620                 


Asp Ala Gln Arg Val Gln Glu Val Phe Ala Trp Thr Thr Thr Ala Glu 
625                 630                 635                 640 


Tyr Glu Ala Leu Asn Phe Arg Arg Glu Ala Leu Thr Val Asp Pro Ala 
                645                 650                 655     


Lys Ala Cys Gln Pro Leu Gly Ala Val Leu Cys Ser Leu Gly Phe Ala 
            660                 665                 670         


Asn Thr Leu Pro Tyr Val His Gly Ser Gln Gly Cys Val Ala Tyr Phe 
        675                 680                 685             


Arg Thr Tyr Phe Asn Arg His Phe Lys Glu Pro Ile Ala Cys Val Ser 
    690                 695                 700                 


Asp Ser Met Thr Glu Asp Ala Ala Val Phe Gly Gly Asn Asn Asn Met 
705                 710                 715                 720 


Asn Leu Gly Leu Gln Asn Ala Ser Ala Leu Tyr Lys Pro Glu Ile Ile 
                725                 730                 735     


Ala Val Ser Thr Thr Cys Met Ala Glu Val Ile Gly Asp Asp Leu Gln 
            740                 745                 750         


Ala Phe Ile Ala Asn Ala Lys Lys Asp Gly Phe Val Asp Ser Ser Ile 
        755                 760                 765             


Ala Val Pro His Ala His Thr Pro Ser Phe Ile Gly Ser His Val Thr 
    770                 775                 780                 


Gly Trp Asp Asn Met Phe Glu Gly Phe Ala Lys Thr Phe Thr Ala Asp 
785                 790                 795                 800 


Tyr Gln Gly Gln Pro Gly Lys Leu Pro Lys Leu Asn Leu Val Thr Gly 
                805                 810                 815     


Phe Glu Thr Tyr Leu Gly Asn Phe Arg Val Leu Lys Arg Met Met Glu 
            820                 825                 830         


Gln Met Ala Val Pro Cys Ser Leu Leu Ser Asp Pro Ser Glu Val Leu 
        835                 840                 845             


Asp Thr Pro Ala Asp Gly His Tyr Arg Met Tyr Ser Gly Gly Thr Thr 
    850                 855                 860                 


Gln Gln Glu Met Lys Glu Ala Pro Asp Ala Ile Asp Thr Leu Leu Leu 
865                 870                 875                 880 


Gln Pro Trp Gln Leu Leu Lys Ser Lys Lys Val Val Gln Glu Met Trp 
                885                 890                 895     


Asn Gln Pro Ala Thr Glu Val Ala Ile Pro Leu Gly Leu Ala Ala Thr 
            900                 905                 910         


Asp Glu Leu Leu Met Thr Val Ser Gln Leu Ser Gly Lys Pro Ile Ala 
        915                 920                 925             


Asp Ala Leu Thr Leu Glu Arg Gly Arg Leu Val Asp Met Met Leu Asp 
    930                 935                 940                 


Ser His Thr Trp Leu His Gly Lys Lys Phe Gly Leu Tyr Gly Asp Pro 
945                 950                 955                 960 


Asp Phe Val Met Gly Leu Thr Arg Phe Leu Leu Glu Leu Gly Cys Glu 
                965                 970                 975     


Pro Thr Val Ile Leu Ser His Asn Ala Asn Lys Arg Trp Gln Lys Ala 
            980                 985                 990         


Met Asn Lys Met Leu Asp Ala Ser  Pro Tyr Gly Arg Asp  Ser Glu Val 
        995                 1000                 1005             


Phe Ile  Asn Cys Asp Leu Trp  His Phe Arg Ser Leu  Met Phe Thr 
    1010                 1015                 1020             


Arg Gln  Pro Asp Phe Met Ile  Gly Asn Ser Tyr Gly  Lys Phe Ile 
    1025                 1030                 1035             


Gln Arg  Asp Thr Leu Ala Lys  Gly Lys Ala Phe Glu  Val Pro Leu 
    1040                 1045                 1050             


Ile Arg  Leu Gly Phe Pro Leu  Phe Asp Arg His His  Leu His Arg 
    1055                 1060                 1065             


Gln Thr  Thr Trp Gly Tyr Glu  Gly Ala Met Asn Ile  Val Thr Thr 
    1070                 1075                 1080             


Leu Val  Asn Ala Val Leu Glu  Lys Leu Asp Ser Asp  Thr Ser Gln 
    1085                 1090                 1095             


Leu Gly  Lys Thr Asp Tyr Ser  Phe Asp Leu Val Arg  
    1100                 1105                 1110 


<210>  65
<211>  1119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  65

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Thr Asn Ala Thr Gly Glu Arg Asn Leu Ala Leu Ile Gln Glu Val Leu 
                85                  90                  95      


Glu Val Phe Pro Glu Thr Ala Arg Lys Glu Arg Arg Lys His Met Met 
            100                 105                 110         


Val Ser Asp Pro Lys Met Lys Ser Val Gly Lys Cys Ile Ile Ser Asn 
        115                 120                 125             


Arg Lys Ser Gln Pro Gly Val Met Thr Val Arg Gly Cys Ala Tyr Ala 
    130                 135                 140                 


Gly Ser Lys Gly Val Val Phe Gly Pro Ile Lys Asp Met Ala His Ile 
145                 150                 155                 160 


Ser His Gly Pro Ala Gly Cys Gly Gln Tyr Ser Arg Ala Glu Arg Arg 
                165                 170                 175     


Asn Tyr Tyr Thr Gly Val Ser Gly Val Asp Ser Phe Gly Thr Leu Asn 
            180                 185                 190         


Phe Thr Ser Asp Phe Gln Glu Arg Asp Ile Val Phe Gly Gly Asp Lys 
        195                 200                 205             


Lys Leu Ser Lys Leu Ile Glu Glu Met Glu Leu Leu Phe Pro Leu Thr 
    210                 215                 220                 


Lys Gly Ile Thr Ile Gln Ser Glu Cys Pro Val Gly Leu Ile Gly Asp 
225                 230                 235                 240 


Asp Ile Ser Ala Val Ala Asn Ala Ser Ser Lys Ala Leu Asp Lys Pro 
                245                 250                 255     


Val Ile Pro Val Arg Cys Glu Gly Phe Arg Gly Val Ser Gln Ser Leu 
            260                 265                 270         


Gly His His Ile Ala Asn Asp Val Val Arg Asp Trp Ile Leu Asn Asn 
        275                 280                 285             


Arg Glu Gly Gln Pro Phe Glu Thr Thr Pro Tyr Asp Val Ala Ile Ile 
    290                 295                 300                 


Gly Asp Tyr Asn Ile Gly Gly Asp Ala Trp Ala Ser Arg Ile Leu Leu 
305                 310                 315                 320 


Glu Glu Met Gly Leu Arg Val Val Ala Gln Trp Ser Gly Asp Gly Thr 
                325                 330                 335     


Leu Val Glu Met Glu Asn Thr Pro Phe Val Lys Leu Asn Leu Val His 
            340                 345                 350         


Cys Tyr Arg Ser Met Asn Tyr Ile Ala Arg His Met Glu Glu Lys His 
        355                 360                 365             


Gln Ile Pro Trp Met Glu Tyr Asn Phe Phe Gly Pro Thr Lys Ile Ala 
    370                 375                 380                 


Glu Ser Leu Arg Lys Ile Ala Asp Gln Phe Asp Asp Thr Ile Arg Ala 
385                 390                 395                 400 


Asn Ala Glu Ala Val Ile Ala Arg Tyr Glu Gly Gln Met Ala Ala Ile 
                405                 410                 415     


Ile Ala Lys Tyr Arg Pro Arg Leu Glu Gly Arg Lys Val Leu Leu Tyr 
            420                 425                 430         


Ile Gly Gly Leu Arg Pro Arg His Val Ile Gly Ala Tyr Glu Asp Leu 
        435                 440                 445             


Gly Met Glu Ile Ile Ala Ala Gly Tyr Glu Phe Ala His Asn Asp Asp 
    450                 455                 460                 


Tyr Asp Arg Thr Leu Pro Asp Leu Lys Glu Gly Thr Leu Leu Phe Asp 
465                 470                 475                 480 


Asp Ala Ser Ser Tyr Glu Leu Glu Ala Phe Val Lys Ala Leu Lys Pro 
                485                 490                 495     


Asp Leu Ile Gly Ser Gly Ile Lys Glu Lys Tyr Ile Phe Gln Lys Met 
            500                 505                 510         


Gly Val Pro Phe Arg Gln Met His Ser Trp Asp Tyr Ser Gly Pro Tyr 
        515                 520                 525             


His Gly Tyr Asp Gly Phe Ala Ile Phe Ala Arg Asp Met Asp Met Thr 
    530                 535                 540                 


Leu Asn Asn Pro Ala Trp Asn Glu Leu Thr Ala Pro Trp Leu Lys Ser 
545                 550                 555                 560 


Ala Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Ala Asp Tyr Lys Asp 
                565                 570                 575     


Asp Asp Asp Lys Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Ala Ser 
            580                 585                 590         


Gln Thr Ile Asp Lys Ile Asn Ser Cys Tyr Pro Leu Phe Glu Gln Asp 
        595                 600                 605             


Glu Tyr Gln Glu Leu Phe Arg Asn Lys Arg Gln Leu Glu Glu Ala His 
    610                 615                 620                 


Asp Ala Gln Arg Val Gln Glu Val Phe Ala Trp Thr Thr Thr Ala Glu 
625                 630                 635                 640 


Tyr Glu Ala Leu Asn Phe Arg Arg Glu Ala Leu Thr Val Asp Pro Ala 
                645                 650                 655     


Lys Ala Cys Gln Pro Leu Gly Ala Val Leu Cys Ser Leu Gly Phe Ala 
            660                 665                 670         


Asn Thr Leu Pro Tyr Val His Gly Ser Gln Gly Cys Val Ala Tyr Phe 
        675                 680                 685             


Arg Thr Tyr Phe Asn Arg His Phe Lys Glu Pro Ile Ala Cys Val Ser 
    690                 695                 700                 


Asp Ser Met Thr Glu Asp Ala Ala Val Phe Gly Gly Asn Asn Asn Met 
705                 710                 715                 720 


Asn Leu Gly Leu Gln Asn Ala Ser Ala Leu Tyr Lys Pro Glu Ile Ile 
                725                 730                 735     


Ala Val Ser Thr Thr Cys Met Ala Glu Val Ile Gly Asp Asp Leu Gln 
            740                 745                 750         


Ala Phe Ile Ala Asn Ala Lys Lys Asp Gly Phe Val Asp Ser Ser Ile 
        755                 760                 765             


Ala Val Pro His Ala His Thr Pro Ser Phe Ile Gly Ser His Val Thr 
    770                 775                 780                 


Gly Trp Asp Asn Met Phe Glu Gly Phe Ala Lys Thr Phe Thr Ala Asp 
785                 790                 795                 800 


Tyr Gln Gly Gln Pro Gly Lys Leu Pro Lys Leu Asn Leu Val Thr Gly 
                805                 810                 815     


Phe Glu Thr Tyr Leu Gly Asn Phe Arg Val Leu Lys Arg Met Met Glu 
            820                 825                 830         


Gln Met Ala Val Pro Cys Ser Leu Leu Ser Asp Pro Ser Glu Val Leu 
        835                 840                 845             


Asp Thr Pro Ala Asp Gly His Tyr Arg Met Tyr Ser Gly Gly Thr Thr 
    850                 855                 860                 


Gln Gln Glu Met Lys Glu Ala Pro Asp Ala Ile Asp Thr Leu Leu Leu 
865                 870                 875                 880 


Gln Pro Trp Gln Leu Leu Lys Ser Lys Lys Val Val Gln Glu Met Trp 
                885                 890                 895     


Asn Gln Pro Ala Thr Glu Val Ala Ile Pro Leu Gly Leu Ala Ala Thr 
            900                 905                 910         


Asp Glu Leu Leu Met Thr Val Ser Gln Leu Ser Gly Lys Pro Ile Ala 
        915                 920                 925             


Asp Ala Leu Thr Leu Glu Arg Gly Arg Leu Val Asp Met Met Leu Asp 
    930                 935                 940                 


Ser His Thr Trp Leu His Gly Lys Lys Phe Gly Leu Tyr Gly Asp Pro 
945                 950                 955                 960 


Asp Phe Val Met Gly Leu Thr Arg Phe Leu Leu Glu Leu Gly Cys Glu 
                965                 970                 975     


Pro Thr Val Ile Leu Ser His Asn Ala Asn Lys Arg Trp Gln Lys Ala 
            980                 985                 990         


Met Asn Lys Met Leu Asp Ala Ser  Pro Tyr Gly Arg Asp  Ser Glu Val 
        995                 1000                 1005             


Phe Ile  Asn Cys Asp Leu Trp  His Phe Arg Ser Leu  Met Phe Thr 
    1010                 1015                 1020             


Arg Gln  Pro Asp Phe Met Ile  Gly Asn Ser Tyr Gly  Lys Phe Ile 
    1025                 1030                 1035             


Gln Arg  Asp Thr Leu Ala Lys  Gly Lys Ala Phe Glu  Val Pro Leu 
    1040                 1045                 1050             


Ile Arg  Leu Gly Phe Pro Leu  Phe Asp Arg His His  Leu His Arg 
    1055                 1060                 1065             


Gln Thr  Thr Trp Gly Tyr Glu  Gly Ala Met Asn Ile  Val Thr Thr 
    1070                 1075                 1080             


Leu Val  Asn Ala Val Leu Glu  Lys Leu Asp Ser Asp  Thr Ser Gln 
    1085                 1090                 1095             


Leu Gly  Lys Thr Asp Tyr Ser  Phe Asp Leu Val Arg  Tyr Pro Tyr 
    1100                 1105                 1110             


Asp Val  Pro Asp Tyr Ala 
    1115                 


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  66

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  67
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  67

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Met Lys Ser Val Lys Asn Ile Gln Lys Ile Thr Lys Ala 
    50                  55                  60                  


Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala Val Gln Gly Ala Pro 
65                  70                  75                  80  


Met Asn Pro Trp Gln Arg Phe Ala Arg Gln Arg Leu Ala Arg Ser Arg 
                85                  90                  95      


Trp Asn Arg Asp Pro Ala Ala Leu Asp Pro Ala Asp Thr Pro Ala Phe 
            100                 105                 110         


Glu Gln Ala Trp Gln Arg Gln Cys His Met Glu Gln Thr Ile Val Ala 
        115                 120                 125             


Arg Val Pro Glu Gly Asp Ile Pro Ala Ala Leu Leu Glu Asn Ile Ala 
    130                 135                 140                 


Ala Ser Leu Ala Ile Trp Leu Asp Glu Gly Asp Phe Ala Pro Pro Glu 
145                 150                 155                 160 


Arg Ala Ala Ile Val Arg His His Ala Arg Leu Glu Leu Ala Phe Ala 
                165                 170                 175     


Asp Ile Ala Arg Gln Ala Pro Gln Pro Asp Leu Ser Thr Val Gln Ala 
            180                 185                 190         


Trp Tyr Leu Arg His Gln Thr Gln Phe Met Arg Pro Glu Gln Arg Leu 
        195                 200                 205             


Thr Arg His Leu Leu Leu Thr Val Asp Asn Asp Arg Glu Ala Val His 
    210                 215                 220                 


Gln Arg Ile Leu Gly Leu Tyr Arg Gln Ile Asn Ala Ser Arg Asp Ala 
225                 230                 235                 240 


Phe Ala Pro Leu Ala Gln Arg His Ser His Cys Pro Ser Ala Leu Glu 
                245                 250                 255     


Glu Gly Arg Leu Gly Trp Ile Ser Arg Gly Leu Leu Tyr Pro Gln Leu 
            260                 265                 270         


Glu Thr Ala Leu Phe Ser Leu Ala Glu Asn Ala Leu Ser Leu Pro Ile 
        275                 280                 285             


Ala Ser Glu Leu Gly Trp His Leu Leu Trp Cys Glu Ala Ile Arg Pro 
    290                 295                 300                 


Ala Ala Pro Met Glu Pro Gln Gln Ala Leu Glu Ser Ala Arg Asp Tyr 
305                 310                 315                 320 


Leu Trp Gln Gln Ser Gln Gln Arg His Gln Arg Gln Trp Leu Glu Gln 
                325                 330                 335     


Met Ile Ser Arg Gln Pro Gly Leu Cys Gly Glu Gln Lys Leu Ile Ser 
            340                 345                 350         


Glu Glu Asp Leu 
        355     


<210>  68
<211>  1723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  68
atggcaatgg ctgttttccg tcgcgaaggg aggcgtctcc tcccttgaat acgccgctcg       60

cccaatcgct gctatccgat ctcctctctc ttctgaccag gaggaaggac ttcttggagt      120

tcgatctatc tcaactcaag tggtgcgtaa ccgcatgaag agtgttaaga acatccaaaa      180

gatcacaaag gcaatgaaga tggttgctgc ttccaagctt agagcagttc aaggcgcgcc      240

aactaatgct actggtgaaa gaaacctcgc tctcatccaa gaggttttgg aagtttttcc      300

tgagactgct aggaaagaaa ggcgtaagca catgatggtg tctgatccta agatgaagtc      360

tgtgggaaag tgcatcatct ctaacagaaa gtctcagcct ggtgtgatga ctgttagagg      420

atgtgcttat gctggatcta agggtgttgt tttcggacct atcaaggata tggctcatat      480

ctctcatgga cctgctggat gtggacaata ttctagagct gagcgtagga actactacac      540

tggtgtttct ggtgtggatt ctttcggaac tctcaacttc acctctgatt tccaagagcg      600

tgatatcgtt ttcggaggtg ataagaagct ctctaagttg atcgaagaga tggaactctt      660

gttcccactc actaagggaa tcactatcca atctgagtgc cctgttggac ttatcggaga      720

tgatatttct gctgtggcta acgcttcttc taaggctctt gataagcctg ttatccctgt      780

tagatgtgaa ggattcaggg gagtttctca gtctcttgga catcatatcg ctaacgatgt      840

ggtgagagat tggatcctta acaacagaga gggacaacct ttcgagacta ctccttacga      900

tgttgctatc atcggagact acaacattgg aggtgatgct tgggcttcta gaatccttct      960

tgaagagatg ggactcagag ttgttgctca atggtctggt gatggtactc ttgttgagat     1020

ggaaaacacc cctttcgtta agctcaacct cgttcattgc taccgtagca tgaactacat     1080

tgctagacac atggaagaga agcaccaaat tccttggatg gagtacaact tcttcggacc     1140

tactaagatc gctgagtctc ttagaaagat cgctgatcag ttcgatgata ccatcagagc     1200

taatgctgag gctgttattg ctagatacga gggacaaatg gctgctatta tcgctaagta     1260

cagacctaga ctcgagggaa gaaaggtttt gctttacatc ggaggactca gacctagaca     1320

tgttattgga gcttacgagg atctcggaat ggaaattatt gctgctggat acgagttcgc     1380

tcacaacgat gattacgata gaactctccc tgacctcaaa gagggaactc ttcttttcga     1440

tgacgcttct tcatacgagc ttgaggcttt tgttaaggct cttaagcctg atctcatcgg     1500

atctggaatc aaagagaagt acatcttcca gaagatggga gttcctttca gacagatgca     1560

ctcttgggat tattctggac cttaccatgg atacgacgga tttgctatct tcgctaggga     1620

tatggatatg actctcaaca atcctgcttg gaacgaactt actgctcctt ggcttaagtc     1680

tgctgccggc tacccttacg acgttcctga ttacgctccc ggg                       1723


<210>  69
<211>  4
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  69

Asp Leu Arg Val 
1               


<210>  70
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  70
atgtcaactc aagtggtgcg taaccgcatg aagagtgtta agaacatcca aaagatcaca       60

aaggcaatga agatggttgc tgcttccaag cttagagcag ttcaaggcgc gccaact         117


<210>  71
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  71

Met Ser Thr Gln Val Val Arg Asn Arg Lys Ser Val Lys Asn Ile Gln 
1               5                   10                  15      


Lys Ile Thr Lys Ala Met Lys Met Val Ala Ala Ser Lys Leu Arg Ala 
            20                  25                  30          


Val Gln Gly Ala Pro Thr Met 
        35                  


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  72
atgatgacta atgctactgg cgaacgtaac ctg                                    33


<210>  73
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  73
ccggctcctc cgctagataa aaatgtga                                          28


<210>  74
<211>  86
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  74

Met Met Glu Trp Phe Tyr Gln Ile Pro Gly Val Asp Glu Leu Arg Ser 
1               5                   10                  15      


Ala Glu Ser Phe Phe Gln Phe Phe Ala Val Pro Tyr Gln Pro Glu Leu 
            20                  25                  30          


Leu Gly Arg Cys Ser Leu Pro Val Leu Ala Thr Phe His Arg Lys Leu 
        35                  40                  45              


Arg Ala Glu Val Pro Leu Gln Asn Arg Leu Glu Asp Asn Asp Arg Ala 
    50                  55                  60                  


Pro Trp Leu Leu Ala Arg Arg Leu Leu Ala Glu Ser Tyr Gln Gln Gln 
65                  70                  75                  80  


Phe Gln Glu Ser Gly Thr 
                85      


<210>  75
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  75

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg 
    50      


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTP scar

<400>  76

Ile Ser Thr Gln Val Val Arg Asn Arg 
1               5                   


<210>  77
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  77

Met Tyr Arg Phe Ala Ser Asn Leu Ala Ser Lys Ala Arg Ile Ala Gln 
1               5                   10                  15      


Asn Ala Arg Gln Val Ser Ser Arg Met Ser Trp Ser Arg Asn Tyr Gly 
            20                  25                  30          


Gly 
    


<210>  78
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  78

Met Tyr Arg Phe Ala Ser Asn Leu Ala Ser Lys Ala Arg Ile Ala Gln 
1               5                   10                  15      


Asn Ala Arg Gln Val Ser Ser Arg Met Ser Trp Ser Arg Asn Tyr 
            20                  25                  30      


<210>  79
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  79

Met Ala Ile Arg Cys Val Ala Ser Arg Lys Thr Leu Ala Gly Leu Lys 
1               5                   10                  15      


Glu Thr Ser Ser Arg Leu Leu Arg Ile Arg Gly Ile Gln Gly Gly 
            20                  25                  30      


<210>  80
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  80

Met Ala Ile Arg Cys Val Ala Ser Arg Lys Thr Leu Ala Gly Leu Lys 
1               5                   10                  15      


Glu Thr Ser Ser Arg Leu Leu Arg Ile Arg Gly Ile Gln Met Ala Ile 
            20                  25                  30          


Arg Cys Val Ala Ser Arg Lys Thr Leu Ala Gly Leu Lys Glu Thr Ser 
        35                  40                  45              


Ser Arg Leu Leu Arg Ile Arg Gly Ile Gln Gly Gly 
    50                  55                  60  


<210>  81
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  81

Met Ala Ile Arg Cys Val Ala Ser Arg Lys Thr Leu Ala Gly Leu Lys 
1               5                   10                  15      


Glu Thr Ser Ser Arg Leu Leu Arg Ile Arg Gly Gly Gly 
            20                  25                  


<210>  82
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  82

Met Ala Ile Arg Cys Val Ala Ser Arg Lys Thr Leu Ala Gly Leu Lys 
1               5                   10                  15      


Glu Thr Ser Ser Arg Leu Leu Arg Ile Arg Gly Met Ala Ile Arg Cys 
            20                  25                  30          


Val Ala Ser Arg Lys Thr Leu Ala Gly Leu Lys Glu Thr Ser Ser Arg 
        35                  40                  45              


Leu Leu Arg Ile Arg Gly Gly Gly 
    50                  55      


<210>  83
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  83

Met Phe Leu Thr Arg Phe Val Gly Arg Arg Phe Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Arg Ser Glu Ser Thr Thr Ala Ala Ala Ala Ala Ser Thr Ile Arg 
            20                  25                  30          


Gly Gly 
        


<210>  84
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  84

Met Ala Ser Thr Arg Val Leu Ala Ser Arg Leu Ala Ser Gln Met Ala 
1               5                   10                  15      


Ala Ser Ala Lys Val Ala Arg Pro Ala Val Arg Val Ala Gln Val Ser 
            20                  25                  30          


Lys Arg Thr Ile Gln Thr Gly Ser Pro Leu Gln Thr Leu Lys Arg Thr 
        35                  40                  45              


Gln Met Thr Ser Ile Val Asn Ala Thr Thr Arg Gln Ala Phe Gln Lys 
    50                  55                  60                  


Arg Ala Tyr Ser Gly Gly 
65                  70  


<210>  85
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  85

Met Ala Met Ala Val Phe Arg Arg Glu Gly Arg Arg Leu Leu Pro Ser 
1               5                   10                  15      


Ile Ala Ala Arg Pro Ile Ala Ala Ile Arg Ser Pro Leu Ser Ser Asp 
            20                  25                  30          


Gln Glu Glu Gly Leu Leu Gly Val Arg Ser Ile Ser Thr Gln Val Val 
        35                  40                  45              


Arg Asn Arg Gly Gly 
    50              


<210>  86
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  86

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu Gln Gln Lys Pro Ser Ala Trp 
            20                  25                  30          


Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly 
    50                  55                  60      


<210>  87
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  87

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu Gln Gln Lys Pro Gly Gly His 
            20                  25                  30          


His His His His His His His His His Gly Gly 
        35                  40              


<210>  88
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Predicted scar

<400>  88

Ile Gln Gly Gly 
1               


<210>  89
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  predicted scar

<400>  89

Ile Gln Gly Gly 
1               


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  predicted scar

<400>  90

Glu Ser Thr Thr Ala Ala Ala Ala Ala Ser Thr Ile Arg Gly Gly 
1               5                   10                  15  


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  predicted scar

<400>  91

Tyr Ser Gly Gly 
1               


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  predicted scar

<400>  92

Ile Ser Thr Gln Val Val Arg Asn Arg Gly Gly 
1               5                   10      


<210>  93
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  predicted scar

<400>  93

Gln Gln Lys Pro Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe 
            20                  25                  30          


Glu Lys Gly Gly 
        35      


<210>  94
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  predicted scar

<400>  94

Lys Pro Gly Gly His His His His His His His His His His Gly Gly 
1               5                   10                  15      


<210>  95
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  95

Met Met Thr Asn Ala Thr Gly Glu Arg Asn Leu Ala Leu Ile Gln Glu 
1               5                   10                  15      


Val Leu Glu Val Phe Pro Glu Thr Ala Arg Lys Glu Arg Arg Lys His 
            20                  25                  30          


Met Met Val Ser Asp Pro Glu Met Glu Ser Val Gly Lys Cys Ile Ile 
        35                  40                  45              


Ser Asn Arg Lys Ser Gln Pro Gly Val Met Thr Val Arg Gly Cys Ala 
    50                  55                  60                  


Tyr Ala Gly Ser Lys Gly Val Val Phe Gly Pro Ile Lys Asp Met Ala 
65                  70                  75                  80  


His Ile Ser His Gly Pro Val Gly Cys Gly Gln Tyr Ser Arg Ala Gly 
                85                  90                  95      


Arg Arg Asn Tyr Tyr Thr Gly Val Ser Gly Val Asp Ser Phe Gly Thr 
            100                 105                 110         


Leu Asn Phe Thr Ser Asp Phe Gln Glu Arg Asp Ile Val Phe Gly Gly 
        115                 120                 125             


Asp Lys Lys Leu Ser Lys Leu Ile Glu Glu Met Glu Leu Leu Phe Pro 
    130                 135                 140                 


Leu Thr Lys Gly Ile Thr Ile Gln Ser Glu Cys Pro Val Gly Leu Ile 
145                 150                 155                 160 


Gly Asp Asp Ile Ser Ala Val Ala Asn Ala Ser Ser Lys Ala Leu Asp 
                165                 170                 175     


Lys Pro Val Ile Pro Val Arg Cys Glu Gly Phe Arg Gly Val Ser Gln 
            180                 185                 190         


Ser Leu Gly His His Ile Ala Asn Asp Val Val Arg Asp Trp Ile Leu 
        195                 200                 205             


Asn Asn Arg Glu Gly Gln Pro Phe Glu Thr Thr Pro Tyr Asp Val Ala 
    210                 215                 220                 


Ile Ile Gly Asp Tyr Asn Ile Gly Gly Asp Ala Trp Ala Ser Arg Ile 
225                 230                 235                 240 


Leu Leu Glu Glu Met Gly Leu Arg Val Val Ala Gln Trp Ser Gly Asp 
                245                 250                 255     


Gly Thr Leu Val Glu Met Glu Asn Thr Pro Phe Val Lys Leu Asn Leu 
            260                 265                 270         


Val His Cys Tyr Arg Ser Met Asn Tyr Ile Ala Arg His Met Glu Glu 
        275                 280                 285             


Lys His Gln Ile Pro Trp Met Glu Tyr Asn Phe Phe Gly Pro Thr Lys 
    290                 295                 300                 


Ile Ala Glu Ser Leu Arg Lys Ile Ala Asp Gln Phe Asp Asp Thr Ile 
305                 310                 315                 320 


Arg Ala Asn Ala Glu Ala Val Ile Ala Arg Tyr Glu Gly Gln Met Ala 
                325                 330                 335     


Ala Ile Ile Ala Lys Tyr Arg Pro Arg Leu Glu Gly Arg Lys Val Leu 
            340                 345                 350         


Leu Tyr Met Gly Gly Leu Arg Pro Arg His Val Ile Gly Ala Tyr Glu 
        355                 360                 365             


Asp Leu Gly Met Glu Ile Ile Ala Ala Gly Tyr Glu Phe Ala His Asn 
    370                 375                 380                 


Asp Asp Tyr Asp Arg Thr Leu Pro Asp Leu Lys Glu Gly Thr Leu Leu 
385                 390                 395                 400 


Phe Asp Asp Ala Ser Ser Tyr Glu Leu Glu Ala Phe Val Lys Ala Leu 
                405                 410                 415     


Lys Pro Asp Leu Ile Gly Ser Gly Ile Lys Glu Lys Tyr Ile Phe Gln 
            420                 425                 430         


Lys Met Gly Val Pro Phe Arg Gln Met His Ser Trp Asp Tyr Ser Gly 
        435                 440                 445             


Pro Tyr His Gly Tyr Asp Gly Phe Ala Ile Phe Ala Arg Asp Met Asp 
    450                 455                 460                 


Met Thr Leu Asn Asn Pro Ala Trp Asn Glu Leu Thr Ala Pro Trp Leu 
465                 470                 475                 480 


Lys Ser Gly Val Arg Pro Arg Ser 
                485             


<210>  96
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  96

Met Lys Gln Val Tyr Leu Asp Asn Asn Ala Thr Thr Arg Leu Asp Pro 
1               5                   10                  15      


Met Val Leu Glu Ala Met Met Pro Phe Leu Thr Asp Phe Tyr Gly Asn 
            20                  25                  30          


Pro Ser Ser Ile His Asp Phe Gly Ile Pro Ala Gln Ala Ala Leu Glu 
        35                  40                  45              


Arg Ala His Gln Gln Ala Ala Ala Leu Leu Gly Ala Glu Tyr Pro Ser 
    50                  55                  60                  


Glu Ile Ile Phe Thr Ser Cys Ala Thr Glu Ala Thr Ala Thr Ala Ile 
65                  70                  75                  80  


Ala Ser Ala Ile Ala Leu Leu Pro Glu Arg Arg Glu Ile Ile Thr Ser 
                85                  90                  95      


Val Val Glu His Pro Ala Thr Leu Ala Ala Cys Glu His Leu Glu Arg 
            100                 105                 110         


Gln Gly Tyr Arg Ile His Arg Ile Ala Val Asp Ser Glu Gly Ala Leu 
        115                 120                 125             


Asp Met Ala Gln Phe Arg Ala Ala Leu Ser Pro Arg Val Ala Leu Val 
    130                 135                 140                 


Ser Val Met Trp Ala Asn Asn Glu Thr Gly Val Leu Phe Pro Ile Gly 
145                 150                 155                 160 


Glu Met Ala Glu Leu Ala His Glu Gln Gly Ala Leu Phe His Cys Asp 
                165                 170                 175     


Ala Val Gln Val Val Gly Lys Ile Pro Ile Ala Val Gly Gln Thr Arg 
            180                 185                 190         


Ile Asp Met Leu Ser Cys Ser Ala His Lys Phe His Gly Pro Lys Gly 
        195                 200                 205             


Val Gly Cys Leu Tyr Leu Arg Arg Gly Thr Arg Phe Arg Pro Leu Leu 
    210                 215                 220                 


Arg Gly Gly His Gln Glu Tyr Gly Arg Arg Ala Gly Thr Glu Asn Ile 
225                 230                 235                 240 


Cys Gly Ile Val Gly Met Gly Ala Ala Cys Glu Leu Ala Asn Ile His 
                245                 250                 255     


Leu Pro Gly Met Thr His Ile Gly Gln Leu Arg Asn Arg Leu Glu His 
            260                 265                 270         


Arg Leu Leu Ala Ser Val Pro Ser Val Met Val Met Gly Gly Gly Gln 
        275                 280                 285             


Pro Arg Val Pro Gly Thr Val Asn Leu Ala Phe Glu Phe Ile Glu Gly 
    290                 295                 300                 


Glu Ala Ile Leu Leu Leu Leu Asn Gln Ala Gly Ile Ala Ala Ser Ser 
305                 310                 315                 320 


Gly Ser Ala Cys Thr Ser Gly Ser Leu Glu Pro Ser His Val Met Arg 
                325                 330                 335     


Ala Met Asn Ile Pro Tyr Thr Ala Ala His Gly Thr Ile Arg Phe Ser 
            340                 345                 350         


Leu Ser Arg Tyr Thr Arg Glu Lys Glu Ile Asp Tyr Val Val Ala Thr 
        355                 360                 365             


Leu Pro Pro Ile Ile Asp Arg Leu Arg Ala Leu Ser Pro Tyr Trp Gln 
    370                 375                 380                 


Asn Gly Lys Pro Arg Pro Ala Asp Ala Val Phe Thr Pro Val Tyr Gly 
385                 390                 395                 400 


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  97

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  98
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  98
tcatcaagcg taatcaggaa catcgtaggg gtaacgaacc agatcgaaag aatagtcgg        59


<210>  99
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  99
aagggcgaat tccagcacac tgg                                               23


<210>  100
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  100
cctgattgta tccgcatctg atgctac                                           27


<210>  101
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  101
aacctgcagg gctaactaac taaccacgga caaaaaacc                              39


<210>  102
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  102
ggtagcatca gatgcggata caatcaggtc atcaagcgta atcaggaaca tcgagg           56


<210>  103
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  103
ccagtgtgct ggaattcgcc cttaacctgc agggctaact aactaaccac g                51


<210>  104
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  104

Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Ala Tyr Pro Tyr Asp Val 
1               5                   10                  15      


Pro Asp Tyr Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Ala 
            20                  25                  30  


<210>  105
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  105
atgatgacta acgctacagg agaa                                              24


<210>  106
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  106
tcatcatcta accaaatcaa aactgtaatc tg                                     32


<210>  107
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  107
ccggctcctc cgctagataa aaatgtgaat ttttgcatgc agcc                        44


<210>  108
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  108
cctgattgta tccgcatctg atgctaccgt ggttga                                 36


<210>  109
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  109
ttctcctgta gcgttagtca tcatccggct cctccgcta                              39


<210>  110
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  110
cagatgcgga tacaatcagg tcatcatcta accaaatcaa aactg                       45


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  111

Met Ser Thr Gln Val Val Arg Asn Arg 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA epitope sequence

<400>  112

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  113
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  113

Thr Ser Ser Gly Gly Thr Ser Thr Gly Gly Ser Thr Thr Thr Thr Ala 
1               5                   10                  15      


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Gly Thr Thr Ser Thr Lys 
            20                  25                  30          


Ala Ser Thr Thr Ser Thr Ser Ser Thr Ser Thr Gly Thr Gly 
        35                  40                  45      


<210>  114
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  114
atgaagggaa atgagattct tgctctt                                           27


<210>  115
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  115
tcatcaatca gcagcataag cacc                                              24


<210>  116
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  116
ttgtaataac ctccagtgat gaattgaata                                        30


<210>  117
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  117
ctagagatta atatggagaa attaagcatg                                        30


<210>  118
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  118
aagagcaaga atctcatttc ccttcatttg taataacctc cagtgatgaa ttgatagtg        59


<210>  119
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  119
tagttttcat gcttaatttc tccatattaa tctctagtca tcaatcagca gcataagcac       60

c                                                                       61


<210>  120
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  promoter

<400>  120

Thr Ala Ala Thr Thr Gly Thr Thr Ala Thr Thr Ala Thr Cys Ala Ala 
1               5                   10                  15      


Thr Ala Ala Ala Ala Gly Ala Ala Thr Thr Thr Thr Thr Ala Thr Thr 
            20                  25                  30          


Gly Thr Thr Ala Thr Thr Gly Thr Gly Thr Thr Ala Thr Thr Thr Gly 
        35                  40                  45              


Gly Thr Ala Ala Thr Thr Thr Ala Thr Gly Cys Thr Thr Ala Thr Ala 
    50                  55                  60                  


Ala Gly Thr Ala Ala Thr Thr Cys Thr Ala Thr Gly Ala Thr Thr Ala 
65                  70                  75                  80  


Ala Thr Thr Gly Thr Gly Ala Ala Thr Thr Ala Ala Thr Ala Ala Gly 
                85                  90                  95      


Ala Cys Thr Ala Ala Thr Gly Ala Gly Gly Ala Thr Ala Ala Thr Ala 
            100                 105                 110         


Ala Thr Thr Gly Ala Ala Thr Thr Thr Gly Ala Thr Thr Ala Ala Ala 
        115                 120                 125             


Thr Thr Ala Ala Cys Thr Cys Thr Gly Cys Gly Ala Ala Gly Cys Cys 
    130                 135                 140                 


Ala Thr Ala Thr Gly Thr Cys Thr Thr Thr Cys Ala Cys Gly Thr Gly 
145                 150                 155                 160 


Ala Gly Ala Gly Thr Cys Ala Cys Gly Thr Gly Ala Thr Gly Thr Cys 
                165                 170                 175     


Thr Cys Cys Gly Cys Gly Ala Cys Ala Gly Gly Cys Thr Gly Gly Cys 
            180                 185                 190         


Ala Cys Gly Gly Gly Gly Cys Thr Thr Ala Gly Thr Ala Thr Thr Ala 
        195                 200                 205             


Cys Cys Cys Cys Cys Gly Thr Gly Cys Cys Gly Gly Gly Ala Thr Cys 
    210                 215                 220                 


Ala Gly Ala Gly Ala Cys Ala Thr Thr Thr Gly Ala Cys Thr Ala Ala 
225                 230                 235                 240 


Ala Thr Gly Thr Thr Gly Ala Cys Thr Thr Gly Gly Ala Ala Thr Ala 
                245                 250                 255     


Ala Thr Ala Gly Cys Cys Cys Thr Thr Gly Gly Ala Thr Thr Ala Gly 
            260                 265                 270         


Ala Thr Gly Ala Cys Ala Cys Gly Thr Gly Gly Ala Cys Gly Cys Thr 
        275                 280                 285             


Cys Ala Gly Gly Ala Thr Cys Thr Gly Thr Gly Ala Thr Gly Cys Thr 
    290                 295                 300                 


Ala Gly Thr Gly Ala Ala Gly Cys Gly Cys Thr Thr Ala Ala Gly Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Cys Gly Ala Ala Thr Cys Thr Gly Ala Cys Gly Gly 
                325                 330                 335     


Ala Ala Gly Ala Gly Cys Gly Gly Ala Cys Ala Ala Ala Cys Gly Cys 
            340                 345                 350         


Ala Cys Ala Thr Gly Gly Ala Cys Thr Ala Thr Gly Gly Cys Cys Cys 
        355                 360                 365             


Ala Cys Thr Gly Cys Thr Thr Thr Ala Thr Thr Ala Ala Ala Gly Ala 
    370                 375                 380                 


Ala Gly Thr Gly Ala Ala Thr Gly Ala Cys Ala Gly Cys Thr Gly Thr 
385                 390                 395                 400 


Cys Thr Thr Thr Gly Cys Thr Thr Cys Ala Ala Gly Ala Cys Gly Ala 
                405                 410                 415     


Ala Gly Thr Ala Ala Ala Gly Ala Ala Thr Ala Gly Thr Gly Gly Ala 
            420                 425                 430         


Ala Ala Ala Cys Gly Cys Gly Thr Ala Ala Ala Gly Ala Ala Thr Ala 
        435                 440                 445             


Ala Gly Cys Gly Thr Ala Cys Thr Cys Ala Gly Thr Ala Cys Gly Cys 
    450                 455                 460                 


Thr Thr Cys Gly Thr Gly Gly Cys Thr Thr Thr Ala Thr Ala Ala Ala 
465                 470                 475                 480 


Thr Ala Gly Thr Gly Cys Thr Thr Cys Gly Thr Cys Thr Thr Ala Thr 
                485                 490                 495     


Thr Cys Thr Thr Cys Gly Thr Thr Gly Thr Ala Thr Cys Ala Thr Cys 
            500                 505                 510         


Ala Ala Cys Gly Ala Ala Gly Ala Ala Gly Thr Thr Ala Ala Gly Cys 
        515                 520                 525             


Thr Thr Thr Gly Thr Thr Cys Thr Gly Cys Gly Thr Thr Thr Thr Ala 
    530                 535                 540                 


Ala 
545 


<210>  121
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  promoter

<400>  121

Thr Ala Ala Thr Thr Gly Thr Thr Ala Thr Thr Ala Thr Cys Ala Ala 
1               5                   10                  15      


Thr Ala Ala Ala Ala Gly Ala Ala Thr Thr Thr Thr Thr Ala Thr Thr 
            20                  25                  30          


Gly Thr Thr Ala Thr Thr Gly Thr Gly Thr Thr Ala Thr Thr Thr Gly 
        35                  40                  45              


Gly Thr Ala Ala Thr Thr Thr Ala Thr Gly Cys Thr Thr Ala Thr Ala 
    50                  55                  60                  


Ala Gly Thr Ala Ala Thr Thr Cys Thr Ala Thr Gly Ala Thr Thr Ala 
65                  70                  75                  80  


Ala Thr Thr Gly Thr Gly Ala Ala Thr Thr Ala Ala Thr Ala Ala Gly 
                85                  90                  95      


Ala Cys Thr Ala Ala Thr Gly Ala Gly Gly Ala Thr Ala Ala Thr Ala 
            100                 105                 110         


Ala Thr Thr Gly Ala Ala Thr Thr Thr Gly Ala Thr Thr Ala Ala Ala 
        115                 120                 125             


Thr Thr Ala Ala Cys Thr Cys Thr Gly Cys Gly Ala Ala Gly Cys Cys 
    130                 135                 140                 


Ala Thr Ala Thr Gly Thr Cys Thr Thr Thr Cys Ala Cys Gly Thr Gly 
145                 150                 155                 160 


Ala Gly Ala Gly Thr Cys Ala Cys Gly Thr Gly Ala Thr Gly Thr Cys 
                165                 170                 175     


Thr Cys Cys Gly Cys Gly Ala Cys Ala Gly Gly Cys Thr Gly Gly Cys 
            180                 185                 190         


Ala Cys Gly Gly Gly Gly Cys Thr Thr Ala Gly Thr Ala Thr Thr Ala 
        195                 200                 205             


Cys Cys Cys Cys Cys Gly Thr Gly Cys Cys Gly Gly Gly Ala Thr Cys 
    210                 215                 220                 


Ala Gly Ala Gly Ala Cys Ala Thr Thr Thr Gly Ala Cys Thr Ala Ala 
225                 230                 235                 240 


Ala Thr Gly Thr Thr Gly Ala Cys Thr Thr Gly Gly Ala Ala Thr Ala 
                245                 250                 255     


Ala Thr Ala Gly Cys Cys Cys Thr Thr Gly Gly Ala Thr Thr Ala Gly 
            260                 265                 270         


Ala Thr Gly Ala Cys Ala Cys Gly Thr Gly Gly Ala Cys Gly Cys Thr 
        275                 280                 285             


Cys Ala Gly Gly Ala Thr Cys Thr Gly Thr Gly Ala Thr Gly Cys Thr 
    290                 295                 300                 


Ala Gly Thr Gly Ala Ala Gly Cys Gly Cys Thr Thr Ala Ala Gly Cys 
305                 310                 315                 320 


Thr Gly Ala Ala Cys Gly Ala Ala Thr Cys Thr Gly Ala Cys Gly Gly 
                325                 330                 335     


Ala Ala Gly Ala Gly Cys Gly Gly Ala Cys Ala Ala Ala Cys Gly Cys 
            340                 345                 350         


Ala Cys Ala Thr Gly Gly Ala Cys Thr Ala Thr Gly Gly Cys Cys Cys 
        355                 360                 365             


Ala Cys Thr Gly Cys Thr Thr Thr Ala Thr Thr Ala Ala Ala Gly Ala 
    370                 375                 380                 


Ala Gly Thr Gly Ala Ala Thr Gly Ala Cys Ala Gly Cys Thr Gly Thr 
385                 390                 395                 400 


Cys Thr Thr Thr Gly Cys Thr Thr Cys Ala Ala Gly Ala Cys Gly Ala 
                405                 410                 415     


Ala Gly Thr Ala Ala Ala Gly Ala Ala Thr Ala Gly Thr Gly Gly Ala 
            420                 425                 430         


Ala Ala Ala Cys Gly Cys Gly Thr Ala Ala Ala Gly Ala Ala Thr Ala 
        435                 440                 445             


Ala Gly Cys Gly Thr Ala Cys Thr Cys Ala Gly Thr Ala Cys Gly Cys 
    450                 455                 460                 


Thr Thr Cys Gly Thr Gly Gly Cys Thr Thr Thr Ala Thr Ala Ala Ala 
465                 470                 475                 480 


Thr Ala Gly Thr Gly Cys Thr Thr Cys Gly Thr Cys Thr Thr Ala Thr 
                485                 490                 495     


Thr Cys Thr Thr Cys Gly Thr Thr Gly Thr Ala Thr Cys Ala Thr Cys 
            500                 505                 510         


Ala Ala Cys Gly Ala Ala Gly Ala Ala Gly Thr Thr Ala Ala Gly Cys 
        515                 520                 525             


<210>  122
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  promoter

<400>  122

Thr Ala Ala Thr Thr Ala Ala Thr Ala Gly Thr Ala Ala Thr Thr Ala 
1               5                   10                  15      


Thr Gly Ala Thr Thr Ala Ala Thr Thr Ala Thr Gly Ala Gly Ala Thr 
            20                  25                  30          


Ala Ala Gly Ala Gly Thr Thr Gly Thr Thr Ala Thr Thr Ala Ala Thr 
        35                  40                  45              


Gly Cys Thr Thr Ala Thr Gly Ala Gly Gly Ala Ala Thr Ala Ala Ala 
    50                  55                  60                  


Gly Ala Ala Thr Gly Ala Thr Thr Ala Ala Thr Ala Thr Thr Gly Thr 
65                  70                  75                  80  


Thr Thr Ala Ala Thr Thr Thr Thr Ala Thr Thr Cys Cys Gly Cys Gly 
                85                  90                  95      


Ala Ala Gly Cys Gly Gly Thr Gly Thr Gly Thr Thr Ala Thr Gly Thr 
            100                 105                 110         


Thr Thr Thr Thr Gly Thr Thr Gly Gly Ala Gly Ala Cys Ala Thr Cys 
        115                 120                 125             


Ala Cys Gly Thr Gly Ala Cys Thr Cys Thr Cys Ala Cys Gly Thr Gly 
    130                 135                 140                 


Ala Thr Gly Thr Cys Thr Cys Cys Gly Cys Gly Ala Cys Ala Gly Gly 
145                 150                 155                 160 


Cys Thr Gly Gly Cys Ala Cys Gly Gly Gly Gly Cys Thr Thr Ala Gly 
                165                 170                 175     


Thr Ala Thr Thr Ala Cys Cys Cys Cys Cys Gly Thr Gly Cys Cys Gly 
            180                 185                 190         


Gly Gly Ala Thr Cys Ala Gly Ala Gly Ala Cys Ala Thr Thr Thr Gly 
        195                 200                 205             


Ala Cys Thr Ala Ala Ala Thr Ala Thr Thr Gly Ala Cys Thr Thr Gly 
    210                 215                 220                 


Gly Ala Ala Thr Ala Ala Thr Ala Gly Cys Cys Cys Thr Thr Gly Gly 
225                 230                 235                 240 


Ala Thr Thr Ala Gly Ala Thr Gly Ala Cys Ala Cys Gly Thr Gly Gly 
                245                 250                 255     


Ala Cys Gly Cys Thr Cys Ala Gly Gly Ala Thr Cys Thr Gly Thr Gly 
            260                 265                 270         


Ala Thr Gly Cys Thr Ala Gly Thr Gly Ala Ala Gly Cys Gly Cys Thr 
        275                 280                 285             


Thr Ala Ala Gly Cys Thr Gly Ala Ala Cys Gly Ala Ala Thr Cys Thr 
    290                 295                 300                 


Gly Ala Cys Gly Gly Ala Ala Gly Ala Gly Cys Gly Gly Ala Cys Ala 
305                 310                 315                 320 


Thr Ala Cys Gly Cys Ala Cys Ala Thr Gly Gly Ala Thr Thr Ala Thr 
                325                 330                 335     


Gly Gly Cys Cys Cys Ala Cys Ala Thr Gly Thr Cys Thr Ala Ala Ala 
            340                 345                 350         


Gly Thr Gly Thr Ala Thr Cys Thr Cys Thr Thr Thr Ala Cys Ala Gly 
        355                 360                 365             


Cys Thr Ala Thr Ala Thr Cys Gly Ala Thr Gly Thr Gly Ala Cys Gly 
    370                 375                 380                 


Thr Ala Ala Gly Ala Thr Gly Cys Thr Thr Thr Ala Cys Thr Thr Cys 
385                 390                 395                 400 


Gly Cys Thr Thr Cys Gly Ala Ala Gly Thr Ala Ala Ala Gly Thr Ala 
                405                 410                 415     


Gly Gly Ala Ala Ala Thr Thr Gly Cys Thr Cys Gly Cys Thr Ala Ala 
            420                 425                 430         


Gly Thr Thr Ala Thr Thr Cys Thr Thr Thr Thr Cys Thr Gly Ala Ala 
        435                 440                 445             


Ala Gly Ala Ala Ala Thr Thr Ala Ala Thr Thr Thr Ala Ala Thr Thr 
    450                 455                 460                 


Cys Thr Ala Ala Ala Thr Thr Ala Ala Ala Thr Thr Ala Ala Ala Thr 
465                 470                 475                 480 


Gly Ala Gly Thr Gly Gly Cys Thr Ala Thr Ala Ala Ala Thr Ala Gly 
                485                 490                 495     


Thr Gly Thr Cys Gly Ala Thr Gly Cys Thr Ala Cys Cys Thr Cys Ala 
            500                 505                 510         


Cys Ala Thr Cys Gly Thr Ala Thr Thr Cys Thr Thr Cys Thr Thr Cys 
        515                 520                 525             


Gly Cys Ala Thr Cys Gly Thr Cys Thr Gly Thr Thr Cys Thr Gly Gly 
    530                 535                 540                 


Thr Thr Thr Thr Ala Ala Gly Gly Ala Ala Thr Thr Cys Thr Ala Gly 
545                 550                 555                 560 


Ala Gly Thr Cys Ala Gly Ala Cys Cys 
                565                 


<210>  123
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  promoter

<400>  123
ggaggaattc caatcccaca aaaatctgag cttaacagca cagttgctcc tctcagagca       60

gaatcgggta ttcaacaccc tcatatcaac tactacgttg tgtataacgg tccacatgcc      120

ggtatatacg atgactgggg ttgtacaaag gcggcaacaa acggcgttcc cggagttgca      180

cacaagaaat ttgccactat tacagaggca agagcagcag ctgacgcgta cacaacaagt      240

cagcaaacag acaggttgaa cttcatcccc aaaggagaag ctcaactcaa gcccaagagc      300

tttgctaagg ccctaacaag cccaccaaag caaaaagccc actggctcac gctaggaacc      360

aaaaggccca gcagtgatcc agccccaaaa gagatctcct ttgccccgga gattacaatg      420

gacgatttcc tctatcttta cgatctagga aggaagttcg aaggtgaagg tgacgacact      480

atgttcacca ctgataatga gaaggttagc ctcttcaatt tcagaaagaa tgctgaccca      540

cagatggtta gagaggccta cgcagcaagt ctcatcaaga cgatctaccc gagtaacaat      600

ctccaggaga tcaaatacct tcccaagaag gttaaagatg cagtcaaaag attcaggact      660

aattgcatca agaacacaga gaaagacata tttctcaaga tcagaagtac tattccagta      720

tggacgattc aaggcttgct tcataaacca aggcaagtaa tagagattgg agtctctaaa      780

aaggtagttc ctactgaatc taaggccatg catggagtct aagattcaaa tcgaggatct      840

aacagaactc gccgtcaaga ctggcgaaca gttcatacag agtcttttac gactcaatga      900

caagaagaaa atcttcgtca acatggtgga gcacgacact ctggtctact ccaaaaatgt      960

caaagataca gtctcagaag atcaaagggc tattgagact tttcaacaaa ggataatttc     1020

gggaaacctc ctcggattcc attgcccagc tatctgtcac ttcatcgaaa ggacagtaga     1080

aaaggaaggt ggctcctaca aatgccatca ttgcgataaa ggaaaggcta tcattcaaga     1140

tctctctgcc gacagtggtc ccaaagatgg acccccaccc acgaggagca tcgtggaaaa     1200

agaagaggtt ccaaccacgt ctacaaagca agtggattga tgtgacatct ccactgacgt     1260

aagggatgac gcacaatccc actatccttc gcaagaccct tcctctatat aaggaagttc     1320

atttcatttg gagaggacac gctcgagtat aagagctcat ttttacaaca attaccaaca     1380

acaacaaaca acaaacaaca ttacaattac atttacaatt atcgatac                  1428


<210>  124
<211>  839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  promoter

<400>  124
gtcaacatgg tggagcacga cactctggtc tactccaaaa atgtcaaaga tacagtctca       60

gaagatcaaa gggctattga gacttttcaa caaaggataa tttcgggaaa cctcctcgga      120

ttccattgcc cagctatctg tcacttcatc gaaaggacag tagaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gctatcattc aagatctctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga ggttccaacc      300

acgtctacaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac tctggtctac      360

tccaaaaatg tcaaagatac agtctcagaa gatcaaaggg ctattgagac ttttcaacaa      420

aggataattt cgggaaacct cctcggattc cattgcccag ctatctgtca cttcatcgaa      480

aggacagtag aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggct      540

atcattcaag atctctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagaggt tccaaccacg tctacaaagc aagtggattg atgtgacatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggaca cgctcgagta taagagctca tttttacaac      780

aattaccaac aacaacaaac aacaaacaac attacaatta catttacaat tatcgatac       839


<210>  125
<211>  172
<212>  PRT
<213>  Tombusvirus

<400>  125

Met Glu Arg Ala Ile Gln Gly Asn Asp Ala Arg Glu Gln Ala Asn Ser 
1               5                   10                  15      


Glu Arg Trp Asp Gly Gly Ser Gly Ser Ser Thr Ser Pro Phe Gln Leu 
            20                  25                  30          


Pro Asp Glu Ser Pro Ser Trp Thr Glu Trp Arg Leu His Asn Asp Glu 
        35                  40                  45              


Thr Asn Ser Asn Gln Asp Asn Pro Leu Gly Phe Lys Glu Ser Trp Gly 
    50                  55                  60                  


Phe Gly Lys Val Val Phe Lys Arg Tyr Leu Arg Tyr Glu Arg Thr Glu 
65                  70                  75                  80  


Thr Ser Leu His Arg Val Leu Gly Ser Trp Thr Gly Asp Ser Val Asn 
                85                  90                  95      


Tyr Ala Ala Ser Arg Phe Phe Gly Val Asn Gln Ile Gly Cys Thr Tyr 
            100                 105                 110         


Ser Ile Arg Phe Arg Gly Val Ser Val Thr Ile Ser Gly Gly Ser Arg 
        115                 120                 125             


Thr Leu Gln His Leu Cys Glu Met Ala Ile Arg Ser Lys Gln Glu Leu 
    130                 135                 140                 


Leu Gln Leu Thr Pro Val Glu Val Glu Ser Asn Val Ser Arg Gly Cys 
145                 150                 155                 160 


Pro Glu Gly Val Glu Thr Phe Glu Glu Glu Ser Glu 
                165                 170         


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  126

Leu His Asn Asp Glu Thr Asn Ser Asn Gln Asp Asn Pro Leu Gly Phe 
1               5                   10                  15      


Lys 
    


<210>  127
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  127

Val Leu Gly Ser Trp Thr Gly Asp Ser Val Asn Tyr Ala Ala Ser Arg 
1               5                   10                  15      


<210>  128
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  128

Ile Asn Ser Cys Tyr Pro Leu Phe Glu Gln Asp Glu Tyr Gln Glu Leu 
1               5                   10                  15      


Phe Arg 
        


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  129

Gln Leu Glu Glu Ala His Asp Ala Gln Arg 
1               5                   10  


<210>  130
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  130

Glu Ala Leu Thr Val Asp Pro Ala Lys 
1               5                   


<210>  131
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  131

Thr Phe Thr Ala Asp Tyr Gln Gly Gln Pro Gly Lys 
1               5                   10          


<210>  132
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  132

Leu Pro Lys Leu Asn Leu Val Thr Gly Phe Glu Thr Tyr Leu Gly Asn 
1               5                   10                  15      


Phe Arg 
        


<210>  133
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  133

Met Met Glu Gln Met Ala Val Pro Cys Ser Leu Leu Ser Asp Pro Ser 
1               5                   10                  15      


Glu Val Leu Asp Thr Pro Ala Asp Gly His Tyr Arg 
            20                  25              


<210>  134
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  134

Met Tyr Ser Gly Gly Thr Thr Gln Gln Glu Met Lys 
1               5                   10          


<210>  135
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  135

Glu Ala Pro Asp Ala Ile Asp Thr Leu Leu Leu Gln Pro Trp Gln Leu 
1               5                   10                  15      


Leu Lys 
        


<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  136

Phe Gly Leu Tyr Gly Asp Pro Asp Phe Val Met Gly Leu Thr Arg 
1               5                   10                  15  


<210>  137
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  137

Asp Ser Glu Val Phe Ile Asn Cys Asp Leu Trp His Phe Arg 
1               5                   10                  


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  138

Gln Pro Asp Phe Met Ile Gly Asn Ser Tyr Gly Lys 
1               5                   10          


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  139

Ala Phe Glu Val Pro Leu Ile Arg 
1               5               


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  140

Leu Gly Phe Pro Leu Phe Asp Arg 
1               5               


<210>  141
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  141

Gln Thr Thr Trp Gly Tyr Glu Gly Ala Met Asn Ile Val Thr Thr Leu 
1               5                   10                  15      


Val Asn Ala Val Leu Glu Lys 
            20              


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  142

Leu Asp Ser Asp Thr Ser Gln Leu Gly Lys 
1               5                   10  


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  143

Thr Asp Tyr Ser Phe Asp Leu Val Arg 
1               5                   


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  144

Leu Gly Thr Gln Met Ile His Phe Val Pro Arg 
1               5                   10      


<210>  145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  145

Met Thr Val Ile Glu Tyr Asp Pro Ala Cys Lys 
1               5                   10      


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  146

Val Met Ile Val Gly Cys Asp Pro Lys 
1               5                   


<210>  147
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  147

Cys Ala Glu Ser Gly Gly Pro Glu Pro Gly Val Gly Cys Ala Gly Arg 
1               5                   10                  15      


<210>  148
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  148

Ser Thr Thr Thr Gln Asn Leu Val Ala Ala Leu Ala Glu Met Gly Lys 
1               5                   10                  15      


<210>  149
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  149

Ser Thr Thr Thr Gln Asn Leu Val Ala Ala Leu Ala Glu Met Gly Lys 
1               5                   10                  15      


Lys 
    


<210>  150
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  150

Gln Thr Asp Arg Glu Asp Glu Leu Ile Ile Ala Leu Ala Glu Lys 
1               5                   10                  15  


<210>  151
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  151

Ala Gln Glu Ile Tyr Ile Val Cys Ser Gly Glu Met Met Ala Met Tyr 
1               5                   10                  15      


Ala Ala Asn Asn Ile Ser Lys 
            20              


<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  152

Ala Val Gln Gly Ala Pro Thr Met Arg 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  153

Leu Gly Gly Leu Ile Cys Asn Ser Arg 
1               5                   


<210>  154
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  154

Ala Gln Asn Thr Ile Met Glu Met Ala Ala Glu Val Gly Ser Val Glu 
1               5                   10                  15      


Asp Leu Glu Leu Glu Asp Val Leu Gln Ile Gly Tyr Gly Asp Val Arg 
            20                  25                  30          


<210>  155
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  155

Leu Cys Leu Ser Thr Asn Gly Leu Val Leu Pro Asp Ala Val Asp Arg 
1               5                   10                  15      


<210>  156
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  156

Phe Ala Ala Ile Leu Glu Leu Leu Ala Asp Val Lys 
1               5                   10          


<210>  157
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  157

Gly Glu Ser Glu Ala Asp Asp Ala Cys Leu Val Ala Val Ala Ser Ser 
1               5                   10                  15      


Arg 
    


<210>  158
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  158

Ala Val Gln Gly Ala Pro Thr Ser Cys Ser Ser Phe Ser Gly Gly Lys 
1               5                   10                  15      


<210>  159
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  159

Ile Asn Ser Val Leu Ile Pro Gly Ile Asn Asp Ser Gly Met Ala Gly 
1               5                   10                  15      


Val Ser Arg 
            


<210>  160
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  160

Gln Val Ala Gln Ala Ile Pro Gln Leu Ser Val Val Gly Ile Ala Gly 
1               5                   10                  15      


Pro Gly Asp Pro Leu Ala Asn Ile Ala Arg 
            20                  25      


<210>  161
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  161

Ile Ala Gly Glu Leu Leu Pro Gly Val Phe His Val Ser Ala Arg 
1               5                   10                  15  


<210>  162
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  162

Gly Thr Ala Gln Asn Pro Asp Ile Tyr Phe Gln Glu Arg 
1               5                   10              


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  163

Ile Pro Phe Val Asn Phe Phe Asp Gly Phe Arg 
1               5                   10      


<210>  164
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  164

Ile Glu Val Leu Glu Tyr Glu Gln Leu Ala Thr Leu Leu Asp Arg Pro 
1               5                   10                  15      


Ala Leu Asp Ser Phe Arg 
            20          


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  165

Ser Gly Gly Ile Thr Val Ser His Leu Arg 
1               5                   10  


<210>  166
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  166

Glu Lys Glu Ile Asp Tyr Val Val Ala Thr Leu Pro Pro Ile Ile Asp 
1               5                   10                  15      


Arg 
    


<210>  167
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  167

Glu Ile Asp Tyr Val Val Ala Thr Leu Pro Pro Ile Ile Asp Arg 
1               5                   10                  15  


<210>  168
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  168

Ile Ala Val Asp Gly Glu Gly Ala Leu Asp Met Ala Gln Phe Arg 
1               5                   10                  15  


<210>  169
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  169

Glu Ile Ile Thr Ser Val Val Glu His Pro Ala Thr Leu Ala Ala Cys 
1               5                   10                  15      


Glu His Met Glu Arg 
            20      


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  170

Ile Asp Met Leu Ser Cys Ser Ala His Lys 
1               5                   10  


<210>  171
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  171

Ala Met Asn Ile Pro Tyr Thr Ala Ala His Gly Thr Ile Arg 
1               5                   10                  


<210>  172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  172

Gln Val Tyr Leu Asp Asn Asn Ala Thr Thr Arg 
1               5                   10      


<210>  173
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  173

Ile Pro Ile Ala Val Gly Gln Thr Arg 
1               5                   


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  174

Gly Val Gly Cys Leu Tyr Leu Arg 
1               5               


<210>  175
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  175

Val Pro Ala Asp Thr Thr Ile Val Gly Leu Leu Gln Glu Ile Gln Leu 
1               5                   10                  15      


Tyr Trp Tyr Asp Lys 
            20      


<210>  176
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  176

Gln Phe Asp Met Val His Ser Asp Glu Trp Ser Met Lys 
1               5                   10              


<210>  177
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  177

Val Val Asp Phe Ser Val Glu Asn Gly His Gln Thr Glu Lys 
1               5                   10                  


<210>  178
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  178

Arg Ala Gly Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
1               5                   10              


<210>  179
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  179

Ala Arg Gly Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gly 
1               5                   10              


<210>  180
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  180

His Val Asp Gln His Phe Gly Ala Thr Pro Arg 
1               5                   10      


<210>  181
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  181

Val Ala Phe Ala Ser Ser Asp Tyr Arg 
1               5                   


<210>  182
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  182

Leu Leu Gln Glu Gln Glu Trp His Gly Asp Pro Asp Pro Arg 
1               5                   10                  


<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  183

Leu Ala Ser Trp Leu Glu Glu Ile Lys Arg 
1               5                   10  


<210>  184
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  184

Val Leu Gly Ser Trp Thr Gly Asp Ser Val Asn Tyr Ala Ala Ser Arg 
1               5                   10                  15      


<210>  185
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  185

Gln Leu Gly Glu Leu Ala Asp Ala Pro Val Asn Ile Asn Arg 
1               5                   10                  


<210>  186
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  186

Phe Val Gly Leu Val Leu Asp Gln Asp Asn Gln Phe Asp Gln Thr Glu 
1               5                   10                  15      


Ala Arg 
        


