                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER
      EUREKA THERAPEUTICS, INC.
 
<120> ANTI-KIR3DL1 ANTIBODIES

<130> 115872-0350

<140>
<141>

<150> 62/457,089
<151> 2017-02-09

<160> 66    

<170> PatentIn version 3.5

<210> 1
<211> 319
<212> PRT
<213> Homo sapiens

<400> 1
His Met Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Arg Cys His Tyr Arg His 
            20                  25                  30          


Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ile His Ile Pro 
        35                  40                  45              


Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe Asn Met Ser Pro Val 
    50                  55                  60                  


Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg Gly Ser His Pro His 
65                  70                  75                  80  


Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro Val Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys Trp Ser Asp Ile Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Lys Glu Gly Ile Ser Lys Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Met Met Leu Ala Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Val Thr Gly Pro Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Gly Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Pro Ala Val Arg Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Pro Arg His Leu His 
305                 310                 315                 


<210> 2
<211> 317
<212> PRT
<213> Homo sapiens

<400> 2
His Val Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Arg Cys His Tyr Arg His 
            20                  25                  30          


Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ile His Val Pro 
        35                  40                  45              


Ile Phe His Gly Arg Leu Phe Gln Glu Ser Phe Asn Met Ser Pro Val 
    50                  55                  60                  


Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg Gly Ser His Pro His 
65                  70                  75                  80  


Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro Val Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys Trp Ser Asp Ile Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Lys Glu Gly Ile Ser Lys Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Met Met Leu Ala Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Val Thr Gly Pro Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Arg Gly Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Pro Ala Val Arg Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Pro Arg His 
305                 310                 315         


<210> 3
<211> 317
<212> PRT
<213> Homo sapiens

<400> 3
His Val Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Arg Cys His Tyr Arg His 
            20                  25                  30          


Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ile His Val Pro 
        35                  40                  45              


Ile Phe His Gly Arg Leu Phe Gln Glu Ser Phe Asn Met Ser Pro Val 
    50                  55                  60                  


Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg Gly Ser His Pro His 
65                  70                  75                  80  


Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro Val Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys Trp Ser Asp Ile Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Lys Glu Gly Ile Ser Lys Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Met Met Leu Ala Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Val Thr Gly Pro Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Arg Gly Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Pro Ala Val Arg Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Pro Arg His 
305                 310                 315         


<210> 4
<211> 318
<212> PRT
<213> Homo sapiens

<400> 4
His Val Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Arg Cys His Tyr Arg His 
            20                  25                  30          


Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ile His Val Pro 
        35                  40                  45              


Ile Phe His Gly Arg Leu Phe Gln Glu Ser Phe Asn Met Ser Pro Val 
    50                  55                  60                  


Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg Gly Ser His Pro His 
65                  70                  75                  80  


Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro Val Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys Trp Ser Asp Ile Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Lys Glu Gly Ile Ser Lys Asp Pro Ser 
    130                 135                 140                 


Ser Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Met Met Leu Ala Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Val Thr Gly Pro Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Gly Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Pro Ala Val Arg Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Pro Arg His Leu 
305                 310                 315             


<210> 5
<211> 319
<212> PRT
<213> Homo sapiens

<400> 5
His Val Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Arg Cys His Tyr Arg His 
            20                  25                  30          


Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ile His Val Pro 
        35                  40                  45              


Ile Phe His Gly Arg Leu Phe Gln Glu Ser Phe Asn Met Ser Pro Val 
    50                  55                  60                  


Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg Gly Ser His Pro His 
65                  70                  75                  80  


Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro Val Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys Trp Ser Asp Ile Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Lys Glu Gly Ile Ser Glu Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Pro Met Met Leu Ala Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Val Thr Gly Pro Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Gly Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Pro Ala Val Arg Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Pro Arg His Leu His 
305                 310                 315                 


<210> 6
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asn Thr Leu Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210> 7
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Leu Phe Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210> 8
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asn Phe Met Leu Thr Gln Pro Leu Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Ala Asn Gly Gly Ser Leu Ala Ser Lys 
            20                  25                  30          


Tyr Val Gln Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Asp Asp Asn Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ala Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn 
                85                  90                  95      


Ser Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210> 9
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Leu Arg Tyr Phe Glu Trp Pro Ile Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 10
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Leu Pro Val Leu Thr Gln Pro Pro Ser Ile Ser Gly Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ala Arg Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Val Pro Gly Glu Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Tyr Asp Asp Gln Gln Pro Ser Gly Ile Ser Gly Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210> 11
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Gly Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Trp Gly Cys Gly Ser Thr Thr Cys Tyr Glu Gly Ala Asp 
            100                 105                 110         


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210> 12
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Asp Phe Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210> 13
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Gln Leu Trp Leu Asp Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 14
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 
                85                  90                  95      


Arg Val Glu Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210> 15
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Phe His Leu Asp Gly Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 16
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Ala Ala Thr Ile Thr Cys Ala Gly Asp Asn Ile Glu Ser Lys Ser Val 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Thr Val Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Pro Ala Thr Leu Thr Ile Ser Arg Ser Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Arg Arg Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 


<210> 17
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ile Ala Ala Ala Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210> 18
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


His Tyr Pro Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Glu Thr Ser Asn Lys Tyr Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr His Cys Phe Leu Ser Tyr Ser Gly 
                85                  90                  95      


Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210> 19
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210> 21
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Asp Val Ser 
1           


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Ser Ser Tyr Thr Ser Ser Asn Thr Leu Val 
1               5                   10  


<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ala Asp Leu Phe Tyr 
1               5   


<210> 26
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Gly Gly Ser Leu Ala Ser Lys Tyr 
1               5               


<210> 27
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Asp Asp Asn 
1           


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gln Ser Tyr Asp Asn Ser Ser Val Val 
1               5                   


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ile Ser Trp Asn Ser Gly Ser Ile 
1               5               


<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ala Ser Ser Leu Arg Tyr Phe Glu Trp Pro Ile Asp Tyr 
1               5                   10              


<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Arg Ser Asn Ile Gly Asn Asn Ala 
1               5               


<210> 33
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Tyr Asp Asp 
1           


<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Ala Ala Trp Asp Asp Ser Leu Asn Gly 
1               5                   


<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Gly Phe Thr Phe Gly Asp Tyr Gly 
1               5               


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Ile Asn Trp Asn Gly Gly Gly Thr 
1               5               


<210> 37
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Ala Arg Val Trp Gly Cys Gly Ser Thr Thr Cys Tyr Glu Gly Ala Asp 
1               5                   10                  15      


Asp Ala Phe Asp Ile 
            20      


<210> 38
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210> 39
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gly Val Ser 
1           


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Met Gln Gly Thr His Trp Pro Leu Thr 
1               5                   


<210> 41
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210> 43
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Ala Arg Gly Arg Glu Gln Leu Trp Leu Asp Gly Met Asp Val 
1               5                   10                  


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Ser Ser Asn Val Gly Asn Asn Tyr 
1               5               


<210> 45
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Asp Asn Asn 
1           


<210> 46
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gly Thr Trp Asp Asn Ser Leu Arg Val Glu Leu 
1               5                   10      


<210> 47
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Ala Arg Tyr Ser Phe His Leu Asp Gly 
1               5                   


<210> 50
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Asn Ile Glu Ser Lys Ser 
1               5       


<210> 51
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Asp Asp Thr 
1           


<210> 52
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Gln Val Trp Asp Asn Arg Arg Asp His Val Val 
1               5                   10      


<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Ile Ser Ser Ser Ser Ser Tyr Thr 
1               5               


<210> 55
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Ala Arg Glu Gly Ile Ala Ala Ala Asp Ala Phe Asp Ile 
1               5                   10              


<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Thr Gly Ala Val Thr Ser Gly His Tyr 
1               5                   


<210> 57
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Glu Thr Ser 
1           


<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Phe Leu Ser Tyr Ser Gly Thr Val Val 
1               5                   


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210> 60
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Ala Arg Tyr Gly Asp 
1               5   


<210> 62
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Y, F, or G 

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or S 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> T, S, D, or G 

<220>
<221> MOD_RES
<222> (6)..(6)
<223> G, S, or D 

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Y, W, A, or G 

<400> 62
Gly Xaa Xaa Phe Xaa Xaa Tyr Xaa 
1               5               


<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> I or M 

<220>
<221> MOD_RES
<222> (2)..(2)
<223> N, S, or Y 

<220>
<221> MOD_RES
<222> (3)..(3)
<223> P, W, or S 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> N, G, or S 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> S, D, or G 

<220>
<221> MOD_RES
<222> (6)..(6)
<223> G or S 

<220>
<221> MOD_RES
<222> (7)..(7)
<223> G, Y, D, S, or N 

<220>
<221> MOD_RES
<222> (8)..(8)
<223> T or I 

<400> 63
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 65
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Gly Gly Gly Gly Ser 
1               5   


<210> 66
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 66
Gly Gly Gly Gly Ser 
1               5   


