                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
 
<120>  MODIFIED RELAXIN POLYPEPTIDES COMPRISING A PHARMACOKINETIC 
       ENHANCER AND USES THEREOF

<130>  46561.2413

<150>  62/627,411
<151>  2018-02-07

<150>  62/456,161
<151>  2017-02-08

<160>  279

<210>  1
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys Asp Ser Trp Met Glu Glu Val Ile 
            20                  25                  30          


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
        35                  40                  45              


Met Ser Thr Trp Ser 
    50              


<210>  2
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys Ala Ser Trp Met Glu Glu Val Ile 
            20                  25                  30          


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
        35                  40                  45              


Met Ser Thr Trp Ser 
    50              


<210>  3
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val 
1               5                   10                  15      


Arg Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser Arg Arg Glu 
            20                  25                  30          


Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly 
        35                  40                  45              


Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg 
    50                  55                  60                  


Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
65                  70                  75                  80  


Lys Arg Ser Leu Ala Arg Phe Cys 
                85              


<210>  4
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys 
            20                  


<210>  5
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val 
1               5                   10                  15      


Arg Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val 
1               5                   10                  15      


Arg Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
            20                  25                  


<210>  7
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly 
1               5                   10                  15      


Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu 
            20                  25                  30          


Gln Lys Arg 
        35  


<210>  8
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Lys Asn Ile Ala Phe Leu Leu Lys Arg 
1               5                   10      


<210>  9
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ile Glu Gly Gly Arg 
1               5       


<210>  10
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  10
caactctaca gtgcattggc taataaatgt tgccatgttg gttgtaccaa aagatctctt     60

gctagatttt gc                                                         72


<210>  11
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  11
gactcatgga tggaggaagt tattaaatta tgcggccgcg aattagttcg cgcgcagatt     60

gccatttgcg gcatgagcac ctggagc                                         87


<210>  12
<211>  159
<212>  DNA
<213>  Homo sapiens

<400>  12
caactctaca gtgcattggc taataaatgt tgccatgttg gttgtaccaa aagatctctt     60

gctagatttt gcgactcatg gatggaggaa gttattaaat tatgcggccg cgaattagtt    120

cgcgcgcaga ttgccatttg cggcatgagc acctggagc                           159


<210>  13
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  13
atgaaaaaga atatcgcatt tcttcttaaa cgg                                  33


<210>  14
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  14
atgattgaag gtggtcgt                                                   18


<210>  15
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ile Glu Gly Gly Arg Asp Ser Trp Met Glu Glu Val Ile Lys Leu 
1               5                   10                  15      


Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly Met Ser 
            20                  25                  30          


Thr Trp Ser Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu 
        35                  40                  45              


Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu 
    50                  55                  60                  


Gly Ser Leu Gln Lys Arg Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys 
65                  70                  75                  80  


Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
                85                  90                  


<210>  16
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Mutant synthetase derived from Methanococcus jannaschii 
       synthetase

<400>  16

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Val 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Tyr Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu His Gly Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Ile His 
145                 150                 155                 160 


Tyr Glu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  17
<211>  77
<212>  DNA
<213>  Artificial

<220>
<223>  Mutant tRNA derived from Methanococcus jannaschii tRNA

<400>  17
ccggcggtag ttcagcaggg cagaacggcg gactctaaat ccgcatggcg ctggttcaaa     60

tccagcccgc cggacca                                                    77


<210>  18
<211>  77
<212>  DNA
<213>  Methanococcus jannaschii

<400>  18
ccggcggtag ttcagcaggg cagaacggcg gactctaaat ccgcatggcg ctggttcaaa     60

tccggcccgc cggacca                                                    77


<210>  19
<211>  88
<212>  DNA
<213>  Artificial

<220>
<223>  An optimized amber supressor tRNA

<400>  19
cccagggtag ccaagctcgg ccaacggcga cggactctaa atccgttctc gtaggagttc     60

gagggttcga atcccttccc tgggacca                                        88


<210>  20
<211>  89
<212>  DNA
<213>  Artificial

<220>
<223>  An optimized AGGA frameshift supressor tRNA

<400>  20
gcgagggtag ccaagctcgg ccaacggcga cggacttcct aatccgttct cgtaggagtt     60

cgagggttcg aatccctccc ctcgcacca                                       89


<210>  21
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       p-azido-L-phenylalanine

<400>  21

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Gly 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Thr Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Thr Tyr Tyr 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  22
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       p-benzoyl-L-phenylalanine

<400>  22

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Gly 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Ser Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Thr Ser His 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  23
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       propargyl-phenylalanine

<400>  23

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Pro Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Ala Ile Tyr 
145                 150                 155                 160 


Leu Ala Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile His 
                165                 170                 175     


Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His Asn 
            180                 185                 190         


Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser Lys 
        195                 200                 205             


Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala Lys 
    210                 215                 220                 


Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro Ile 
225                 230                 235                 240 


Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys Arg 
                245                 250                 255     


Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu Leu 
            260                 265                 270         


Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys Asn 
        275                 280                 285             


Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys Arg 
    290                 295                 300                 


Leu 
305 


<210>  24
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       propargyl-phenylalanine

<400>  24

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Pro Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Ile Pro Tyr 
145                 150                 155                 160 


Leu Pro Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile His 
                165                 170                 175     


Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His Asn 
            180                 185                 190         


Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser Lys 
        195                 200                 205             


Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala Lys 
    210                 215                 220                 


Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro Ile 
225                 230                 235                 240 


Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys Arg 
                245                 250                 255     


Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu Leu 
            260                 265                 270         


Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys Asn 
        275                 280                 285             


Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys Arg 
    290                 295                 300                 


Leu 
305 


<210>  25
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       propargyl-phenylalanine

<400>  25

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Lys Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Ala Ile Tyr 
145                 150                 155                 160 


Leu Ala Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile His 
                165                 170                 175     


Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His Asn 
            180                 185                 190         


Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser Lys 
        195                 200                 205             


Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala Lys 
    210                 215                 220                 


Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro Ile 
225                 230                 235                 240 


Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys Arg 
                245                 250                 255     


Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu Leu 
            260                 265                 270         


Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys Asn 
        275                 280                 285             


Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys Arg 
    290                 295                 300                 


Leu 
305 


<210>  26
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  26

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Thr 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Asn Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Leu His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  27
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  27

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Thr 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Ser Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Leu His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  28
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       p-azido-phenylalanine

<400>  28

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Thr Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Val His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  29
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  29

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Thr 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Ser Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Ser His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  30
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-acetyl-phenylalanine

<400>  30

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Cys His 
145                 150                 155                 160 


Tyr Arg Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  31
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of p-acetyl 
       -phenylalanine

<400>  31

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Thr His 
145                 150                 155                 160 


Tyr Arg Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  32
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-acetyl-phenylalanine

<400>  32

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Gly His 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ile Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  33
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  33

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Arg Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Val Ile His 
145                 150                 155                 160 


Tyr Asp Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  34
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  34

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Gly 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Thr Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Thr Tyr Tyr 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     

<210>  35
<211>  24
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Modified relaxin polypeptide A chain

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is a non-naturally encoded amino acid such as 
       para-acetyl-L-phenylalanine

<400>  35

Xaa Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys 
            20                  


<210>  36
<211>  24
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Modified relaxin polypeptide A chain

<400>  36

Asn Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys 
            20                  


<210>  37
<211>  29
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Modified relaxin polypeptide B chain

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa is a non-naturally encoded amino acid such as 
       para-acetyl-L-phenylalanine

<400>  37

Ala Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val 
1               5                   10                  15      


Arg Ala Gln Ile Ala Ile Cys Gly Xaa Ser Thr Trp Ser 
            20                  25                  


<210>  38
<211>  94
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Modified relaxin polypeptide (prepro sequence)

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa is a non-naturally encoded amino acid such as 
       para-acetyl-L-phenylalanine

<400>  38

Met Ile Glu Glu Gly Arg Ala Ser Trp Met Glu Glu Val Ile Lys Leu 
1               5                   10                  15      


Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly Met Ser 
            20                  25                  30          


Thr Trp Ser Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu 
        35                  40                  45              


Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu 
    50                  55                  60                  


Gly Ser Leu Gln Gly Arg Xaa Leu Tyr Ser Ala Leu Ala Asn Lys Cys 
65                  70                  75                  80  


Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
                85                  90                  


<210>  39
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Exemplary insulin leader amino acid sequence

<400>  39

Met Ile Glu Glu Gly Arg
1               5      


<210> 40

<400> 40
000

<210> 41

<400> 41
000

<210> 42

<400> 42
000

<210> 43

<400> 43
000

<210> 44

<400> 44
000

<210> 45

<400> 45
000

<210> 46

<400> 46
000

<210> 47

<400> 47
000

<210> 48

<400> 48
000

<210> 49

<400> 49
000

<210> 50

<400> 50
000

<210>  51
<211>  27
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  PCR Primer

<400>  51
aaatactctg tctggatcgg tggctcc                                           27


<210>  52
<211>  30
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  PCR Primer

<400>  52
cacataggta acgagtcaga gctttggcta                                        30


<210>  53
<211>  22
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  PCR Primer

<400>  53
gctggagtcg atcaactcta gg                                                22


<210>  54
<211>  21
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  PCR Primer

<400>  54
ccaatttcgc tttgccttgt c                                                 21


<210>  55
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Polyhistidine purification tag

<400>  55

His His His His His His Ser Gly Gly 
1               5                   


<210> 56

<400> 56
000

<210> 57

<400> 57
000

<210> 58

<400> 58
000

<210> 59

<400> 59
000

<210> 60

<400> 60
000

<210> 61

<400> 61
000

<210> 62

<400> 62
000

<210> 63

<400> 63
000

<210> 64

<400> 64
000

<210> 65

<400> 65
000

<210> 66

<400> 66
000

<210> 67

<400> 67
000

<210> 68

<400> 68
000

<210> 69

<400> 69
000

<210> 70

<400> 70
000

<210> 71

<400> 71
000

<210> 72

<400> 72
000

<210> 73

<400> 73
000

<210> 74

<400> 74
000

<210> 75

<400> 75
000

<210> 76

<400> 76
000

<210> 77

<400> 77
000

<210> 78

<400> 78
000

<210> 79

<400> 79
000

<210> 80

<400> 80
000

<210> 81

<400> 81
000

<210> 82

<400> 82
000

<210> 83

<400> 83
000

<210> 84

<400> 84
000

<210> 85

<400> 85
000

<210> 86

<400> 86
000

<210> 87

<400> 87
000

<210> 88

<400> 88
000

<210> 89

<400> 89
000

<210> 90

<400> 90
000

<210> 91

<400> 91
000

<210> 92

<400> 92
000

<210> 93

<400> 93
000

<210> 94

<400> 94
000

<210> 95

<400> 95
000

<210> 96

<400> 96
000

<210> 97

<400> 97
000

<210> 98

<400> 98
000

<210> 99

<400> 99
000

<210> 100

<400> 100
000

<210>  101
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  101

Gly Gly Gly Gly Ser Glu 
1               5       


<210>  102
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  102

Asp Arg Asp Asp Arg Asp 
1               5       


<210>  103
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  103

Lys Lys Lys Lys Lys Lys Glu 
1               5           


<210>  104
<211>  13
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 13
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  104

Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
1               5                   10              


<210>  105
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  105

Gly Gly Gly Glu Glu Glu Glu 
1               5           


<210>  106
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  106

Glu Glu Glu Gly Gly Gly Glu 
1               5           


<210>  107
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  107

Lys Lys Lys Gly Gly Gly Glu 
1               5           


<210>  108
<211>  11
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 11
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  108

Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr Glu 
1               5                   10      


<210>  109
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  109

Gly Gly Gly Lys Lys Lys Glu 
1               5           


<210>  110
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 10
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  110

Gly Ser His His His His His Gly Ser Glu 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..4
<223> Sarcosine (N-methyl glycine)

<220>
<221> MOD_RES
<222> 6..9
<223> Sarcosine (N-methyl glycine)

<220>
<221> MOD_RES
<222> 10
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH


<400>  111

Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Glu 
1               5                   10  


<210>  112
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..4
<223> Sarcosine (N-methyl glycine)

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH


<400>  112

Xaa Xaa Xaa Xaa Ser Glu 
1               5       


<210>  113
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..3
<223> Sarcosine (N-methyl glycine)

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH


<400>  113

Xaa Xaa Xaa Glu Glu Glu 
1               5       


<210>  114
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 9
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  114

Lys Lys Ser Gly Gly Ser Gly Gly Glu 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 9
<223> alpha carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  115

Lys Lys Ser Gly Gly Ser Gly Gly Glu 
1               5                   


<210>  116
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 9
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  116

Lys Lys Ser Ala Gly Ser Ala Gly Glu 
1               5                   


<210>  117
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 8
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  117

Lys Ser Gly Gly Ser Gly Gly Glu 
1               5               


<210>  118
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 10
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  118

Lys Lys Lys Ser Gly Gly Ser Gly Gly Glu 
1               5                   10  


<210>  119
<211>  11
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 11
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  119

Lys Lys Ser Gly Gly Ser Gly Gly Glu Glu Glu 
1               5                   10      


<210>  120
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..6
<223> D-amino acid(s)

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  120

Lys Lys Lys Lys Lys Lys Glu 
1               5           


<210>  121
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 9
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  121

Glu Glu Ser Gly Gly Ser Gly Gly Glu 
1               5                   


<210>  122
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  122

Gly Gly Gly Gly Ser Glu 
1               5       


<210>  123
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 9
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  123

Gly Ser Gly Ser Gly Ser Gly Ser Glu 
1               5                   


<210>  124
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  124

Glu Glu Glu Gly Gly Gly Glu 
1               5           


<210>  125
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C17-COOH

<400>  125

Glu Glu Glu Gly Gly Gly Glu 
1               5           


<210>  126
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-CH3

<400>  126

Glu Glu Glu Gly Gly Gly Glu 
1               5           


<210>  127
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-CH3

<400>  127

Glu Glu Glu Gly Gly Gly Glu 
1               5           


<210>  128
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> D-amino acid(s)

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  128

Glu Glu Glu Gly Gly Gly Glu 
1               5           


<210>  129
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  129

Glu Glu Glu Gly Gly Gly Glu 
1               5           


<210>  130
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 8
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  130

Glu Gly Gly Gly Gly Ser Lys Glu 
1               5               


<210>  131
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  131

Glu Glu Glu Glu Glu Glu Glu 
1               5           


<210> 132

<400> 132
000

<210>  133
<211>  20
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 20
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-CH3

<400>  133

Glu Glu Glu Glu Pro Glu Glu Glu Glu Pro Glu Glu Glu Glu Pro Glu 
1               5                   10                  15      


Glu Glu Glu Glu 
            20  


<210>  134
<211>  20
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 20
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-CH3

<400>  134

Glu Glu Glu Glu Pro Glu Glu Glu Glu Pro Glu Glu Glu Glu Pro Glu 
1               5                   10                  15      


Glu Glu Glu Glu 
            20  


<210>  135
<211>  20
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 20
<223> optionally linked to a half-life extending moiety
      such as C14-CH3

<400>  135

Glu Glu Glu Glu Pro Glu Glu Glu Glu Pro Glu Glu Glu Glu Pro Glu 
1               5                   10                  15      


Glu Gly Gly Gly 
            20  


<210>  136
<211>  20
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 20
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-CH3

<400>  136

Glu Glu Glu Glu Gly Glu Glu Glu Glu Gly Glu Glu Glu Glu Gly Glu 
1               5                   10                  15      


Glu Glu Glu Glu 
            20  


<210>  137
<211>  27
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 27
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  137

Lys Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Pro Lys Gly 
1               5                   10                  15      


Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
            20                  25          


<210>  138
<211>  22
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 22
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  138

Glu Ala Gln Lys Ala Gln Ala Glu Ala Gln Lys Ala Gln Ala Glu Ala 
1               5                   10                  15      


Gln Lys Ala Gln Ala Glu 
            20          


<210>  139
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  139

Gly Gly Gly Gly Ser Glu 
1               5       


<210>  140
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  140

Lys Lys Glu 
1           


<210>  141
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  141

Lys Lys Glu 
1           


<210>  142
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  142

Lys Lys Glu 
1           


<210>  143
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-CH3

<400>  143

Glu Glu Glu Glu Glu Glu Glu 
1               5           


<210>  144
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-CH3

<400>  144

Lys Lys Glu 
1           


<210>  145
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  145

Lys Gly Pro Glu 
1               


<210>  146
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  146

Lys Gly Pro Lys Gly Pro Glu 
1               5           


<210>  147
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  147

Ser Gly Gly Gly Ser Glu 
1               5       


<210>  148
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  148

Lys Gly Gly Gly Ser Glu 
1               5       


<210>  149
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  149

Lys Gly Gly Gly Ser Glu Glu 
1               5           


<210>  150
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  150

Gly Ser Pro Gly Ser Pro Glu 
1               5           


<210>  151
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  151

Gly Gly Gly Gly Pro Glu 
1               5       


<210>  152
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  152

Glu Gly Gly Ser Glu 
1               5   


<210>  153
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  153

Glu Gly Gly Gly Pro Glu 
1               5       


<210>  154
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  154

Lys Gly Pro Gly Ser Glu Glu 
1               5           


<210> 155

<400> 155
000

<210>  156
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  156

Lys Lys Gly Gly Ser Glu 
1               5       


<210>  157
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..4
<223> Sarcosine (N-methyl glycine)

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH


<400>  157

Xaa Xaa Xaa Xaa Ser Glu 
1               5       


<210>  158
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..3
<223> Sarcosine (N-methyl glycine)

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH


<400>  158

Xaa Xaa Xaa Glu Glu Glu 
1               5       


<210>  159
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta


<400>  159

Ala Ala Ala Ala Ala Ser Xaa 
1               5           


<210>  160
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  160

Ala Ala Ala Ala Ser Xaa 
1               5       


<210>  161
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  161

Ala Ala Ala Ser Xaa 
1               5   


<210>  162
<211>  12
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 12
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 12
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  162

Ala Ala Ser Ala Ala Ser Ala Ala Ser Ala Ala Xaa 
1               5                   10          


<210>  163
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 10
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 10
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  163

Ala Ala Ser Ala Ala Ser Ala Ala Ser Xaa 
1               5                   10  


<210>  164
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  164

Ala Ala Ser Ala Ala Ser Xaa 
1               5           


<210>  165
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  165

Ala Ala Ser Ser Ala Xaa 
1               5       


<210>  166
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  166

Ala Ala Ser Xaa 
1               


<210>  167
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  167

Ala Gly Ala Gly Ser Xaa 
1               5       


<210>  168
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  168

Ala Gly Ala Gly Ser Xaa 
1               5       


<210>  169
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  169

Ala Gly Ala Ser Xaa 
1               5   


<210>  170
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  170

Ala Gly Ala Ser Xaa 
1               5   


<210>  171
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  171

Ala Gly Gly Ala Ser Xaa 
1               5       


<210>  172
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  172

Ala Gly Gly Ala Ser Xaa 
1               5       


<210>  173
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  173

Ala Gly Gly Gly Ser Xaa 
1               5       


<210>  174
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  174

Ala Gly Gly Gly Ser Xaa 
1               5       


<210>  175
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH



<400>  175

Ala Ser Xaa 
1           


<210>  176
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MISC_FEATURE
<222> 1..5
<223> joined by beta linkages

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  176

Ala Ala Ala Ala Ser Xaa 
1               5       


<210>  177
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MISC_FEATURE
<222> 1..4
<223> joined by beta linkages

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  177

Ala Ala Ala Ser Xaa 
1               5   


<210>  178
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MISC_FEATURE
<222> 1..3
<223> joined by beta linkages

<220>
<221> MOD_RES
<222> 4
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  178

Ala Ala Ser Xaa 
1               


<210>  179
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MISC_FEATURE
<222> 1..2
<223> joined by beta linkage

<220>
<221> MOD_RES
<222> 3
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  179

Ala Ser Xaa 
1           


<210>  180
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  180

Glu Gly Gly Glu Gly Gly Xaa 
1               5           


<210>  181
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  181

Glu Gly Gly Glu Gly Pro Xaa 
1               5           


<210>  182
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  182

Glu Gly Pro Glu Gly Pro Xaa 
1               5           


<210>  183
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  183

Gly Gly Ala Ala Ser Xaa 
1               5       


<210>  184
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  184

Gly Gly Ala Ala Ser Xaa 
1               5       


<210>  185
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  185

Gly Gly Ala Ser Xaa 
1               5   


<210>  186
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  186

Gly Gly Ala Ser Xaa 
1               5   


<210>  187
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  187

Gly Gly Gly Ala Ser Xaa 
1               5       


<210>  188
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  188

Gly Gly Gly Ala Ser Xaa 
1               5       


<210>  189
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 8
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 8
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  189

Gly Gly Gly Gly Gly Gly Ser Xaa 
1               5               


<210>  190
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  190

Gly Gly Gly Gly Gly Ser Xaa 
1               5           


<210>  191
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH

<400>  191

Gly Gly Gly Gly Ser 
1               5   


<210>  192
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MISC_FEATURE
<222> 5..6
<223> joined by -PEG2-PEG2- linkage

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  192

Gly Gly Gly Gly Ser Xaa 
1               5       


<210>  193
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as C14-COOH


<400>  193

Gly Gly Gly Gly Ser Xaa 
1               5       


<210>  194
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH 
      having malonic acid tail


<400>  194

Gly Gly Gly Gly Ser Xaa 
1               5       


<210>  195
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH having 
      a succinic acid tail


<400>  195

Gly Gly Gly Gly Ser Xaa 
1               5       


<210>  196
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  196

Gly Gly Gly Gly Ser Xaa 
1               5       


<210>  197
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  197

Gly Gly Gly Gly Ser Xaa 
1               5       


<210>  198
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH

<400>  198

Gly Gly Gly Gly Thr 
1               5   


<210>  199
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  199

Gly Gly Gly Ser Gly Xaa 
1               5       


<210>  200
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  200

Gly Gly Gly Ser Ser Ser Xaa 
1               5           


<210>  201
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  201

Gly Gly Gly Ser Ser Xaa 
1               5       


<210>  202
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  202

Gly Gly Gly Ser Ser Xaa 
1               5       


<210>  203
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  203

Gly Gly Gly Ser Xaa 
1               5   


<210>  204
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 8
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 8
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  204

Gly Gly Gly Thr Thr Thr Thr Xaa 
1               5               


<210>  205
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 9
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 9
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  205

Gly Gly Ser Gly Gly Gly Gly Gly Xaa 
1               5                   


<210>  206
<211>  12
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 12
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 12
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  206

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Xaa 
1               5                   10          


<210>  207
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 10
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 10
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  207

Gly Gly Ser Gly Gly Ser Gly Gly Ser Xaa 
1               5                   10  


<210>  208
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  208

Gly Gly Ser Gly Gly Ser Xaa 
1               5           


<210>  209
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  209

Gly Gly Ser Gly Gly Xaa 
1               5       


<210>  210
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  210

Gly Gly Ser Gly Ser Xaa 
1               5       


<210>  211
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  211

Gly Gly Ser Ser Gly Xaa 
1               5       


<210>  212
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  212

Gly Gly Ser Ser Ser Ser Xaa 
1               5           


<210>  213
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  213

Gly Gly Ser Ser Ser Xaa 
1               5       


<210>  214
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  214

Gly Gly Ser Ser Xaa 
1               5   


<210>  215
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  215

Gly Gly Ser Ser Xaa 
1               5   


<210>  216
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  216

Gly Gly Ser Ser Xaa 
1               5   


<210>  217
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  217

Gly Gly Ser Xaa 
1               


<210>  218
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  218

Gly Gly Thr Thr Thr Thr Xaa 
1               5           


<210>  219
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  219

Gly Gly Thr Thr Thr Xaa 
1               5       


<210>  220
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  220

Gly Gly Thr Thr Xaa 
1               5   


<210>  221
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  221

Gly Ser Gly Gly Gly Xaa 
1               5       


<210>  222
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  222

Gly Ser Gly Gly Ser Xaa 
1               5       


<210>  223
<211>  11
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 11
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 11
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  223

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Xaa 
1               5                   10      


<210>  224
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 9
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 9
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  224

Gly Ser Gly Ser Gly Ser Gly Ser Xaa 
1               5                   


<210>  225
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  225

Gly Ser Gly Ser Gly Ser Xaa 
1               5           


<210>  226
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  226

Gly Ser Gly Ser Gly Xaa 
1               5       


<210>  227
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  227

Gly Ser Gly Ser Xaa 
1               5   


<210>  228
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  228

Gly Ser Pro Xaa 
1               


<210>  229
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  229

Gly Ser Ser Ser Ser Xaa 
1               5       


<210>  230
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  230

Gly Ser Ser Ser Xaa 
1               5   


<210>  231
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  231

Gly Ser Ser Xaa 
1               


<210>  232
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  232

Gly Ser Xaa 
1           


<210>  233
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  233

Gly Thr Thr Thr Xaa 
1               5   


<210>  234
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  234

Gly Thr Thr Xaa 
1               


<210>  235
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  235

Lys Gly Gly Gly Ser Xaa 
1               5       


<210>  236
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  236

Lys Gly Gly Lys Gly Gly Xaa 
1               5           


<210>  237
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MISC_FEATURE
<222> 2..3
<223> joined by -PEG2-PEG2- linkage

<220>
<221> MOD_RES
<222> 3
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  237

Lys Lys Xaa 
1           


<210>  238
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH

<400>  238

Lys Lys Ser 
1           


<210>  239
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  239

Lys Lys Ser Xaa 
1               


<210>  240
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH

<400>  240

Lys Lys Thr 
1           


<210>  241
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  241

Lys Lys Thr Xaa 
1               


<210>  242
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a malonic acid tail


<400>  242

Lys Lys Xaa 
1           


<210>  243
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a succinic acid tail


<400>  243

Lys Lys Xaa 
1           


<210>  244
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  244

Lys Lys Xaa 
1           


<210>  245
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  245

Lys Pro Lys Ser Xaa 
1               5   


<210>  246
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 8
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 8
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  246

Lys Ser Gly Gly Gly Ser Lys Xaa 
1               5               


<210>  247
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> (D)-Glu-gamma, Asp-alpha, Asp-beta, (D)-Asp-alpha, 
      or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  247

Lys Ser Gly Lys Ser Gly Xaa 
1               5           


<210>  248
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 7
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  248

Ser Gly Gly Gly Gly Gly Xaa 
1               5           


<210>  249
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  249

Ser Gly Gly Gly Gly Xaa 
1               5       


<210>  250
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  250

Ser Gly Gly Gly Gly Xaa 
1               5       


<210>  251
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  251

Ser Gly Gly Gly Ser Xaa 
1               5       


<210>  252
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 5
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  252

Ser Gly Gly Gly Xaa 
1               5   


<210>  253
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 4
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  253

Ser Gly Gly Xaa 
1               


<210>  254
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> Glu-gamma, (D)-Glu-gamma, Asp-alpha, Asp-beta, 
      (D)-Asp-alpha, or (D)-Asp-beta

<220>
<221> MOD_RES
<222> 3
<223> optionally linked to a half-life extending moiety
      such as a fatty acid, such as C13-COOH, C14-COOH, or C15-COOH


<400>  254

Ser Gly Xaa 
1           


<210>  255
<211>  3
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 3
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  255

Gly Ser Glu 
1           


<210>  256
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  256

Gly Gly Ser Glu 
1               


<210>  257
<211>  4
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 4
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  257

Gly Ser Pro Glu 
1               


<210>  258
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  258

Glu Gly Gly Glu Gly Gly Glu 
1               5           


<210>  259
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MISC_FEATURE
<222> 1..2
<223> joined by gamma linkage

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  259

Glu Gly Gly Gly Gly Ser Glu 
1               5           


<210>  260
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  260

Glu Gly Gly Glu Gly Pro Glu 
1               5           


<210>  261
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C14-COOH

<400>  261

Glu Gly Pro Glu Gly Pro Glu 
1               5           


<210>  262
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  262

Lys Gly Gly Gly Ser Glu 
1               5       


<210>  263
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 8
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  263

Lys Ser Gly Gly Gly Ser Lys Glu 
1               5               


<210>  264
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  264

Lys Ser Gly Lys Ser Gly Glu 
1               5           


<210>  265
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  265

Lys Gly Gly Lys Gly Gly Glu 
1               5           


<210>  266
<211>  5
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 5
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  266

Lys Pro Lys Ser Glu 
1               5   


<210>  267
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..6
<223> D-amino acid(s)

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  267

Lys Lys Lys Lys Lys Lys Glu 
1               5           


<210>  268
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..6
<223> 2,3-diaminopropionic acid

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH


<400>  268

Xaa Xaa Xaa Xaa Xaa Xaa Glu 
1               5           


<210>  269
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..6
<223> 6-N-methyllysine

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH


<400>  269

Xaa Xaa Xaa Xaa Xaa Xaa Glu 
1               5           


<210>  270
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 1..3
<223> D-amino acid(s)

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  270

Lys Lys Lys Gly Gly Gly Glu 
1               5           


<210>  271
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C15-COOH

<400>  271

Gly Gly Gly Glu Glu Glu Glu 
1               5           


<210>  272
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C17-COOH

<400>  272

Gly Gly Gly Glu Glu Glu Glu 
1               5           


<210>  273
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  273

Lys Lys Lys Lys Pro Glu 
1               5       


<210>  274
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  274

Lys Lys Lys Lys Lys Lys 
1               5       


<210>  275
<211>  8
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 8
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  275

Lys Ala Gln Lys Ala Gln Ala Glu 
1               5               


<210>  276
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 10
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  276

Lys Lys Lys Lys Pro Lys Lys Lys Lys Glu 
1               5                   10  


<210>  277
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 10
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-COOH

<400>  277

Lys Lys Lys Lys Lys Lys Gly Gly Gly Glu 
1               5                   10  


<210>  278
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 7
<223> D-amino acid(s)

<220>
<221> MOD_RES
<222> 7
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-CH3

<400>  278

Glu Glu Glu Gly Gly Gly Glu 
1               5           


<210>  279
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Synthetic linker

<220>
<221> MOD_RES
<222> 1
<223> optionally linked to side-chain carbonyl group of a
      para-acetyl-phenylalanine residue of a modified relaxin polypeptide

<220>
<221> MOD_RES
<222> 6
<223> gamma carbon optionally linked to a half-life extending moiety
      such as C13-CH3

<400>  279

Gly Gly Gly Gly Ser Glu 
1               5       
