                         SEQUENCE LISTING

<110>  Georg-Augsut-Universitaet Goettingen Stiftung oeffentlichen
        Rechts, Universitaetsmedizin
       Georg-August-Universitaet Goettingen Stiftung oeffentlichen
        Rechts, Universitaetsmedizin
 
<120>  Method for re-expression of different hypermethylated genes 
       involved in fibrosis, like hypermethylated RASAL1, and use 
       thereof in threatment of fibrosis as well as kits fo parts for 
       re-expressions of hypermethylated genes including RASAL1 in a 
       subject

<130>  3294-082 PCT-1

<150>  EP17157906.3
<151>  2017-02-24

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  1800
<212>  DNA
<213>  homo sapiens

<400>  1
caggagaggt gacgcgtggc ccacgcctca aaggacaaca atcagaatat caaacacttt       60

ctggacgtgt attaggtact tgtcactgtc ctgagacttt tatcttcatt aactctttta      120

attctttcaa aatcctgtga ctgaaatgca atgtcatcct cactcaacag atgagaaaac      180

caaaccaaag cacagagagg ttgaatggct tacccaagtc cagacagcta ccaaatggca      240

gagccaggat tcgaacccct ggaaggcaaa tcagttactg actgtgagac ctctgccaag      300

ttatttaatc cctctgaacc tcagtttctt tatccataaa ctgcggataa tggggtaaca      360

gtggagtagt gtgtagtgca catctggaga caaaaatgag ctaatcccag taaagcgctt      420

agaacagtgc ctggcaccca tgaagtgttc aaacaactgt agatgacttt ttatcatcgc      480

tgtagtggtt atcttcaagc cttcccctcc cccatctggc cgcggcttcc tcccccgcag      540

tgccagcccg tgacgttaga gcagagtctg ggttctgtgt ttaactggaa actagaacga      600

gatggaaggg gatgttcaag gcccctccct tgactctgaa cggaccccca gggaacatgc      660

gaccctctct ctggcgacgc ctcccaccca ccactaatac ttgctcctgg accggggggc      720

gcggaggttg gagagaggag gcaggtgtct gcatggtagg caaggagggg tgggggcgga      780

gaggtgtgaa tatgttggat gagggacagg cgggggcaca gaccatgtct tttaagccca      840

atgccaactc accaggagcc agcggccacg cccatcagga cgggggcccc tccccacctg      900

gcggtgcacc cttgtctccg ccgcccgtgc gctctggcgc gcatgactgg ggtgccggta      960

gagggcgcgc gagggggccc ggggtcaggt gggggacccc attggaggcg ggattgtggg     1020

gaggtccctg ggccgcccct cccgccccct gcccgcccag cctgcttgtc tggagctcca     1080

gacgcctcgg caagagcccg ctgcgccccc tgcgcgctcc tcctgctcgg agcacggctc     1140

ctacctgtag agtccggacg ggcgctccct ccccgggcac ctacaccttc tcctctttcg     1200

gaaatctccc atccagctac ccgggtctcg gacaggcggc actgggacca cgaggcaggg     1260

agccaggctt gaagcaggtg acatgtagac gtcccctggt ccagcctcgg aacctgagcg     1320

cccttctgcc tggaaagttt gtggctaggc gccatggcca agagcagctc cctgaatgtt     1380

cgcgtggtgg agggccgcgc gctgcctgcc aaggacgtgt gagtactcct cgggcgcttc     1440

tgggtgaggg gcgcgcaagg cctggggtgg ggccgacgtc gccctttccg cgtgccaggg     1500

cgggttggca ggagggcgag gggttcttgt ccaagactgg tcttggggca gttccgcttt     1560

aaaggggcga gaggccgcat gcccatggct gtcccggtgg gaggggggcg cctagagtta     1620

gcagatgccc cgcctcaccc ccgggcaggg gagggggtgt ctttgttccc gggatgtact     1680

aaagggggtc gtccagagct gaagagggga ttagagggcc atattctgtc agatctggga     1740

ggggagaaag cggggggtct cttccttagt ccaggcagat gttggaggtg gctcctccag     1800


<210>  2
<211>  2070
<212>  DNA
<213>  Mus musculus

<400>  2
cagcctttct gaatactccc cagttagtta aaccacagac ttcgagaagg aaggtagctc       60

tgccagcgtc taccctggga caagccttct gttcacatga tcccatttaa aactcgcaaa      120

ggcacaaagc atcttgggaa cggaggaaaa aggaagaaga gctttgcgtg gggggtgtgg      180

aagggcctcc taaaagcctt gccaggagac gtgacattta aggcacacct tgaagaagaa      240

gaacaacaaa aaataccgta tgctctgtgc ctgattaggt gtgtaccact cttctgaggc      300

ccgtgtggga gtatctcatt taattctctc tcaaccctgt aaatgagaca cgtgtcgtgt      360

catgctccct gaacagatga gaaaactaaa ccgaggaaca gagaggttaa gtgactgact      420

catctaagac caggcattac cacatctacc aaatggcagc agagtcagaa ctcaaaccca      480

gaaaggagac ttctggcaag tgtcccccac ctctcaggac cccaatttgt gtgtgtgtgt      540

ttattttggt tttttgtttt gttttgtttt taaatccata gatagagggc tcccatgaca      600

tacagagttg ccgagggctc aaaactgaga taatccccat gaaaggctca agccgtgcct      660

ggaacttggt taagtgttcg aggattgcag atggctctta tcgtgccgcc cgggcggtgt      720

tatctccgcg cctcccctcc ccctgcggcc gcggcttcct cccccgcagt ggcagccggt      780

gacgtgggag cctccgctgg cacactccgg gtttaattgg agacgaagag aagatgcaag      840

gggatgttcg aggtccctcc ctccactcgc atcagacccc cagggagcgt gcgccgcctg      900

ccgcccagag agagtactgt tccgggaccc cgaggctggt gttggggtgg caggtggagg      960

aggtgggaga ggtgtggagg tgctgggttg agggccggca ggagacaccc gggttcttgg     1020

agggttcaaa ataagctcag taacagcctg cagccctgct tgactgctcg cgcctcctcc     1080

accccacccc ttgacccata gcgcctgggg ggtccccggc tgagtgcagt agcctggggt     1140

gccagcaggg ggcgctcgcg taggggttca gggcgggcgg ggcagctgcg gggggcggga     1200

tcgggaggga cctcccgggc ggcagacgcc tggctcagcc tgcccagatc gcagcgcaca     1260

gctacctgta gctctggacg catgtcccct tccgggaccc agcacgcctc cctcctagcc     1320

ctgcatccag cccactcgca ccccagaccc ggacacgtgg gaaccggctg acagcgtgct     1380

tggcccgcag ctgatgacat gtagggtcac ctcctggtcc agcctcagaa cctcggcaga     1440

ctccttgcct ggaaagtttg ggactgtgcg acatggccaa gagcggctcg ctgagtatcc     1500

gcgtggtgga gggacgagca ctgcccgcca aggacgtgtg agtccccggg tgcccactgg     1560

ggtgcgtaga agggttgtgg ggagccctgt ttaggacccg ctgctgggga tccgccctcc     1620

ctattctgtg ggagggggcg cccaggctta gcaggtgcgg caccttgctc cctccacctc     1680

caccccaccc ccgggaagga gggtgtcttt gttctaggat gtccccaagt gggtcttaca     1740

ggacgggtta aaggagctct ggactgggta ctcttagagc ctaggagggg gttgagcgat     1800

cccttcctta gctccagcag gtgttggagg tggggcttct ccgagcgaca gaagaggcta     1860

tccagagacc actaggggta gagcccctga gggctgtgat ccagactgac cccaagattt     1920

ttcatgcctt aggggtggtg tttagatttg cagcgcttca ccaggtggtc ctctaacccg     1980

gaaccccggt tttgtacctg caaacctagg gtggactatc tcagatctcc aagtgatcta     2040

agagacactc gcaggtgcac gtgtgatagg                                      2070


<210>  3
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  3
agtactcaca cgtccttggc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  4
ggcgcgcatg actggggtgc                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  5
aagcccaatg ccaactcacc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  6
atccataaac tgcggataat                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  7
atttggtagc tgtctggact                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  8
accccttgac ccatagcgcc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  9
gagacacccg ggttcttgga                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  10
cgaacactta accaagttcc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  11
catgacatac agagttgccg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  12
taaatgagat actcccacac                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  13
aaggaagaag agctttgcgt                                                   20


<210>  14
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  peptide

<400>  14

Gly Gly Gly Ser Gly 
1               5   


<210>  15
<211>  2376
<212>  PRT
<213>  artificial

<220>
<223>  peptide

<400>  15

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Arg Gly Met Asp Lys Lys 
1               5                   10                  15      


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
            20                  25                  30          


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
        35                  40                  45              


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
    50                  55                  60                  


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
65                  70                  75                  80  


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
                85                  90                  95      


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
            100                 105                 110         


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
        115                 120                 125             


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
    130                 135                 140                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                165                 170                 175     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            180                 185                 190         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        195                 200                 205             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    210                 215                 220                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
225                 230                 235                 240 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                245                 250                 255     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            260                 265                 270         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        275                 280                 285             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    290                 295                 300                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
305                 310                 315                 320 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                325                 330                 335     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            340                 345                 350         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        355                 360                 365             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    370                 375                 380                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
385                 390                 395                 400 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                405                 410                 415     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            420                 425                 430         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        435                 440                 445             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
465                 470                 475                 480 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                485                 490                 495     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            500                 505                 510         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        515                 520                 525             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    530                 535                 540                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
545                 550                 555                 560 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                565                 570                 575     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            580                 585                 590         


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 
    610                 615                 620                 


Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp 
625                 630                 635                 640 


Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp 
                645                 650                 655     


Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 
            660                 665                 670         


Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 
        675                 680                 685             


Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
                725                 730                 735     


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
            740                 745                 750         


Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro 
        755                 760                 765             


Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys 
    770                 775                 780                 


Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile 
785                 790                 795                 800 


Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr 
                805                 810                 815     


Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp 
865                 870                 875                 880 


Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg 
                885                 890                 895     


Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu 
            900                 905                 910         


Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe 
        915                 920                 925             


Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
    930                 935                 940                 


Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys 
945                 950                 955                 960 


Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser 
                965                 970                 975     


Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn 
            980                 985                 990         


Tyr His His Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
        995                 1000                 1005             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1010                 1015                 1020             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1025                 1030                 1035             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1040                 1045                 1050             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1055                 1060                 1065             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1070                 1075                 1080             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1085                 1090                 1095             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1100                 1105                 1110             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1115                 1120                 1125             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1160                 1165                 1170             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1175                 1180                 1185             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1190                 1195                 1200             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1205                 1210                 1215             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1235                 1240                 1245             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1250                 1255                 1260             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1265                 1270                 1275             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1280                 1285                 1290             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1295                 1300                 1305             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1310                 1315                 1320             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1325                 1330                 1335             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1340                 1345                 1350             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1355                 1360                 1365             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Pro Lys Lys 
    1370                 1375                 1380             


Lys Arg  Lys Val Ser Arg Gly  Gly Gly Ser Gly Tyr  Tyr Thr His 
    1385                 1390                 1395             


Leu Gly  Ser Gly Pro Thr Val  Ala Ser Ile Arg Glu  Leu Met Glu 
    1400                 1405                 1410             


Glu Arg  Tyr Gly Glu Lys Gly  Lys Ala Ile Arg Ile  Glu Lys Val 
    1415                 1420                 1425             


Ile Tyr  Thr Gly Lys Glu Gly  Lys Ser Ser Arg Gly  Cys Pro Ile 
    1430                 1435                 1440             


Ala Lys  Trp Val Ile Arg Arg  His Thr Leu Glu Glu  Lys Leu Leu 
    1445                 1450                 1455             


Cys Leu  Val Arg His Arg Ala  Gly His His Cys Gln  Asn Ala Val 
    1460                 1465                 1470             


Ile Val  Ile Leu Ile Leu Ala  Trp Glu Gly Ile Pro  Arg Ser Leu 
    1475                 1480                 1485             


Gly Asp  Thr Leu Tyr Gln Glu  Leu Thr Asp Thr Leu  Arg Lys Tyr 
    1490                 1495                 1500             


Gly Asn  Pro Thr Ser Arg Arg  Cys Gly Leu Asn Asp  Asp Arg Thr 
    1505                 1510                 1515             


Cys Ala  Cys Gln Gly Lys Asp  Pro Asn Thr Cys Gly  Ala Ser Phe 
    1520                 1525                 1530             


Ser Phe  Gly Cys Ser Trp Ser  Met Tyr Phe Asn Gly  Cys Lys Tyr 
    1535                 1540                 1545             


Ala Arg  Ser Lys Thr Pro Arg  Lys Phe Arg Leu Ala  Gly Asp Asn 
    1550                 1555                 1560             


Pro Lys  Glu Glu Glu Val Leu  Arg Lys Ser Phe Gln  Asp Leu Ala 
    1565                 1570                 1575             


Thr Glu  Val Ala Pro Leu Tyr  Lys Arg Leu Ala Pro  Gln Ala Tyr 
    1580                 1585                 1590             


Gln Asn  Gln Val Thr Asn Glu  Glu Ile Ala Ile Asp  Cys Arg Leu 
    1595                 1600                 1605             


Gly Leu  Lys Glu Gly Arg Pro  Phe Ala Gly Val Thr  Ala Cys Met 
    1610                 1615                 1620             


Asp Phe  Cys Ala His Ala His  Lys Asp Gln His Asn  Leu Tyr Asn 
    1625                 1630                 1635             


Gly Cys  Thr Val Val Cys Thr  Leu Thr Lys Glu Asp  Asn Arg Cys 
    1640                 1645                 1650             


Val Gly  Lys Ile Pro Glu Asp  Glu Gln Leu His Val  Leu Pro Leu 
    1655                 1660                 1665             


Tyr Lys  Met Ala Asn Thr Asp  Glu Phe Gly Ser Glu  Glu Asn Gln 
    1670                 1675                 1680             


Asn Ala  Lys Val Gly Ser Gly  Ala Ile Gln Val Leu  Thr Ala Phe 
    1685                 1690                 1695             


Pro Arg  Glu Val Arg Arg Leu  Pro Glu Pro Ala Lys  Ser Cys Arg 
    1700                 1705                 1710             


Gln Arg  Gln Leu Glu Ala Arg  Lys Ala Ala Ala Glu  Lys Lys Lys 
    1715                 1720                 1725             


Ile Gln  Lys Glu Lys Leu Ser  Thr Pro Glu Lys Ile  Lys Gln Glu 
    1730                 1735                 1740             


Ala Leu  Glu Leu Ala Gly Ile  Thr Ser Asp Pro Gly  Leu Ser Leu 
    1745                 1750                 1755             


Lys Gly  Gly Leu Ser Gln Gln  Gly Leu Lys Pro Ser  Leu Lys Val 
    1760                 1765                 1770             


Glu Pro  Gln Asn His Phe Ser  Ser Phe Lys Tyr Ser  Gly Asn Ala 
    1775                 1780                 1785             


Val Val  Glu Ser Tyr Ser Val  Leu Gly Asn Cys Arg  Pro Ser Asp 
    1790                 1795                 1800             


Pro Tyr  Ser Met Asn Ser Val  Tyr Ser Tyr His Ser  Tyr Tyr Ala 
    1805                 1810                 1815             


Gln Pro  Ser Leu Thr Ser Val  Asn Gly Phe His Ser  Lys Tyr Ala 
    1820                 1825                 1830             


Leu Pro  Ser Phe Ser Tyr Tyr  Gly Phe Pro Ser Ser  Asn Pro Val 
    1835                 1840                 1845             


Phe Pro  Ser Gln Phe Leu Gly  Pro Gly Ala Trp Gly  His Ser Gly 
    1850                 1855                 1860             


Ser Ser  Gly Ser Phe Glu Lys  Lys Pro Asp Leu His  Ala Leu His 
    1865                 1870                 1875             


Asn Ser  Leu Ser Pro Ala Tyr  Gly Gly Ala Glu Phe  Ala Glu Leu 
    1880                 1885                 1890             


Pro Ser  Gln Ala Val Pro Thr  Asp Ala His His Pro  Thr Pro His 
    1895                 1900                 1905             


His Gln  Gln Pro Ala Tyr Pro  Gly Pro Lys Glu Tyr  Leu Leu Pro 
    1910                 1915                 1920             


Lys Ala  Pro Leu Leu His Ser  Val Ser Arg Asp Pro  Ser Pro Phe 
    1925                 1930                 1935             


Ala Gln  Ser Ser Asn Cys Tyr  Asn Arg Ser Ile Lys  Gln Glu Pro 
    1940                 1945                 1950             


Val Asp  Pro Leu Thr Gln Ala  Glu Pro Val Pro Arg  Asp Ala Gly 
    1955                 1960                 1965             


Lys Met  Gly Lys Thr Pro Leu  Ser Glu Val Ser Gln  Asn Gly Gly 
    1970                 1975                 1980             


Pro Ser  His Leu Trp Gly Gln  Tyr Ser Gly Gly Pro  Ser Met Ser 
    1985                 1990                 1995             


Pro Lys  Arg Thr Asn Gly Val  Gly Gly Ser Trp Gly  Val Phe Ser 
    2000                 2005                 2010             


Ser Gly  Glu Ser Pro Ala Ile  Val Pro Asp Lys Leu  Ser Ser Phe 
    2015                 2020                 2025             


Gly Ala  Ser Cys Leu Ala Pro  Ser His Phe Thr Asp  Gly Gln Trp 
    2030                 2035                 2040             


Gly Leu  Phe Pro Gly Glu Gly  Gln Gln Ala Ala Ser  His Ser Gly 
    2045                 2050                 2055             


Gly Arg  Leu Arg Gly Lys Pro  Trp Ser Pro Cys Lys  Phe Gly Asn 
    2060                 2065                 2070             


Ser Thr  Ser Ala Leu Ala Gly  Pro Ser Leu Thr Glu  Lys Pro Trp 
    2075                 2080                 2085             


Ala Leu  Gly Ala Gly Asp Phe  Asn Ser Ala Leu Lys  Gly Ser Pro 
    2090                 2095                 2100             


Gly Phe  Gln Asp Lys Leu Trp  Asn Pro Met Lys Gly  Glu Glu Gly 
    2105                 2110                 2115             


Arg Ile  Pro Ala Ala Gly Ala  Ser Gln Leu Asp Arg  Ala Trp Gln 
    2120                 2125                 2130             


Ser Phe  Gly Leu Pro Leu Gly  Ser Ser Glu Lys Leu  Phe Gly Ala 
    2135                 2140                 2145             


Leu Lys  Ser Glu Glu Lys Leu  Trp Asp Pro Phe Ser  Leu Glu Glu 
    2150                 2155                 2160             


Gly Pro  Ala Glu Glu Pro Pro  Ser Lys Gly Ala Val  Lys Glu Glu 
    2165                 2170                 2175             


Lys Gly  Gly Gly Gly Ala Glu  Glu Glu Glu Glu Glu  Leu Trp Ser 
    2180                 2185                 2190             


Asp Ser  Glu His Asn Phe Leu  Asp Glu Asn Ile Gly  Gly Val Ala 
    2195                 2200                 2205             


Val Ala  Pro Ala His Gly Ser  Ile Leu Ile Glu Cys  Ala Arg Arg 
    2210                 2215                 2220             


Glu Leu  His Ala Thr Thr Pro  Leu Lys Lys Pro Asn  Arg Cys His 
    2225                 2230                 2235             


Pro Thr  Arg Ile Ser Leu Val  Phe Tyr Gln His Lys  Asn Leu Asn 
    2240                 2245                 2250             


Gln Pro  Asn His Gly Leu Ala  Leu Trp Glu Ala Lys  Met Lys Gln 
    2255                 2260                 2265             


Leu Ala  Glu Arg Ala Arg Ala  Arg Gln Glu Glu Ala  Ala Arg Leu 
    2270                 2275                 2280             


Gly Leu  Gly Gln Gln Glu Ala  Lys Leu Tyr Gly Lys  Lys Arg Lys 
    2285                 2290                 2295             


Trp Gly  Gly Thr Val Val Ala  Glu Pro Gln Gln Lys  Glu Lys Lys 
    2300                 2305                 2310             


Gly Val  Val Pro Thr Arg Gln  Ala Leu Ala Val Pro  Thr Asp Ser 
    2315                 2320                 2325             


Ala Val  Thr Val Ser Ser Tyr  Ala Tyr Thr Lys Val  Thr Gly Pro 
    2330                 2335                 2340             


Tyr Ser  Arg Trp Ile Thr Arg  Pro Leu Glu Gln Lys  Leu Ile Ser 
    2345                 2350                 2355             


Glu Glu  Asp Leu Ala Ala Asn  Asp Ile Leu Asp Tyr  Lys Asp Asp 
    2360                 2365                 2370             


Asp Asp  Lys 
    2375     


<210>  16
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  16
actttttatc atcgctgtag                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  17
cgcccgactc cctcccagat                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  18
gccagaggcg cccaggaacc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  19
ctccccgacg aagccgctcc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  20
tcgcaggtaa ttattgccag                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  21
ctccctgagc tggctgcagc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  22
tgtgctctct ctgggcaccc                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  23
cccccgtgcc aggccggagt                                                   20


