                         SEQUENCE LISTING

<110>  H. Lee Moffitt Cancer Center and Research Institute, Inc.
 
<120>  TIM3-BINDING CHIMERIC ANTIGEN RECEPTORS

<130>  320803-2140

<150>  US 62/462,059
<151>  2017-02-22

<150>  US 62/592,110
<151>  2017-11-29

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Asn Met Ala Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Ala Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Ser Gln Leu Leu Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  2
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Gly Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  3
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Val 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ala Ala 
            100                 105                 110 


<210>  4
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala 
            100                 105                 110 


<210>  5
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Leu Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala 
            100                 105                 


<210>  6
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Ser Ala Ser Pro Gly Glu Lys Val Thr 
            20                  25                  30          


Met Ser Cys Ser Ala Ser Ser Ser Leu Thr Tyr Met Tyr Trp Phe Gln 
        35                  40                  45              


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Arg Thr Ser Asn 
    50                  55                  60                  


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
65                  70                  75                  80  


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
                85                  90                  95      


Tyr Thr Cys Gln Gln Tyr His Ser Tyr Pro Pro Thr Phe Gly Gly Gly 
            100                 105                 110         


Thr Lys Leu Glu Ile Lys Ala Ala Ala 
        115                 120     


<210>  7
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(31)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (33)..(34)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (45)..(47)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (49)..(51)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (69)..(70)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (90)..(91)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Xaa is any amino acid

<400>  7

Xaa Ile Val Xaa Thr Gln Ser Pro Ala Xaa Xaa Ser Xaa Ser Xaa Gly 
1               5                   10                  15      


Xaa Xaa Val Thr Xaa Xaa Cys Xaa Ala Ser Xaa Ser Xaa Xaa Xaa Tyr 
            20                  25                  30          


Xaa Xaa Trp Tyr Gln Gln Lys Xaa Gly Xaa Ser Pro Xaa Xaa Xaa Ile 
        35                  40                  45              


Xaa Xaa Xaa Ser Xaa Leu Xaa Ser Gly Val Pro Xaa Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Xaa Xaa Tyr Xaa Leu Xaa Ile Xaa Ser Xaa Glu Xaa 
65                  70                  75                  80  


Glu Asp Xaa Ala Xaa Tyr Tyr Cys Gln Xaa Xaa Ser Xaa Pro Xaa Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala 
            100                 105                 


<210>  8
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  9
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
1               5                   10                  15      


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
            20                  25                  30          


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
        35                  40                  45              


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
    50                  55                  60                  


<210>  10
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  11
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  15
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile 
            20                  25                  30          


Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Ser Asn Met Ala Val Ser Trp Ile Arg Gln Pro Ser 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
                85                  90                  95      


Ser Arg Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Ala Ala Asp 
            100                 105                 110         


Thr Ala Thr Tyr Tyr Cys Val Arg Ser Gln Leu Leu Arg Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly Gly Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu 
        195                 200                 205             


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Lys Asp 
    210                 215                 220                 


Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Val Thr Phe Gly Ala Gly Thr 
                245                 250                 255     


Lys Leu Glu Leu Lys Ala Ala Ala 
            260                 


<210>  16
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile 
            20                  25                  30          


Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Ser Asn Met Ala Val Ser Trp Ile Arg Gln Pro Ser 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
                85                  90                  95      


Ser Arg Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Ala Ala Asp 
            100                 105                 110         


Thr Ala Thr Tyr Tyr Cys Val Arg Ser Gln Leu Leu Arg Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser 
        195                 200                 205             


Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp 
    210                 215                 220                 


Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr 
225                 230                 235                 240 


Tyr Cys Gln Asn Gly His Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Ala Ala Ala 
            260                 


<210>  17
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile 
            20                  25                  30          


Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Ser Asn Met Ala Val Ser Trp Ile Arg Gln Pro Ser 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
                85                  90                  95      


Ser Arg Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Ala Ala Asp 
            100                 105                 110         


Thr Ala Thr Tyr Tyr Cys Val Arg Ser Gln Leu Leu Arg Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly Gln Lys Val Thr Ile Thr 
                165                 170                 175     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
            180                 185                 190         


Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr Glu Ile Ser Lys Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Trp Asn Tyr Pro Leu Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Ala Ala Ala 
            260             


<210>  18
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile 
            20                  25                  30          


Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Ser Asn Met Ala Val Ser Trp Ile Arg Gln Pro Ser 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
                85                  90                  95      


Ser Arg Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Ala Ala Asp 
            100                 105                 110         


Thr Ala Thr Tyr Tyr Cys Val Arg Ser Gln Leu Leu Arg Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Ser 
                165                 170                 175     


Cys Ser Ala Ser Ser Ser Leu Thr Tyr Met Tyr Trp Phe Gln Gln Lys 
            180                 185                 190         


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Arg Thr Ser Asn Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Tyr His Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Ala Ala Ala 
            260             


<210>  19
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Phe Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Ala Tyr Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
145                 150                 155                 160 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Ser Cys Ser Ala Ser 
                165                 170                 175     


Ser Ser Leu Thr Tyr Met Tyr Trp Phe Gln Gln Lys Pro Gly Ser Ser 
            180                 185                 190         


Pro Lys Pro Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro 
        195                 200                 205             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    210                 215                 220                 


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr 
225                 230                 235                 240 


His Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Ala Ala Ala 
            


<210>  20
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Phe Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Ala Tyr Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Thr 
145                 150                 155                 160 


Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser 
                165                 170                 175     


Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu 
            180                 185                 190         


Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile 
        195                 200                 205             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser 
    210                 215                 220                 


Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
225                 230                 235                 240 


Gly His Ser Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
                245                 250                 255     


Lys Ala Ala Ala 
            260 


<210>  21
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Phe Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Ala Tyr Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr 
145                 150                 155                 160 


Leu Ser Val Ser Leu Gly Gly Arg Val Thr Ile Thr Cys Lys Ala Ser 
                165                 170                 175     


Asp His Ile Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn 
            180                 185                 190         


Ala Pro Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val 
        195                 200                 205             


Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Lys Asp Tyr Thr Leu Ser 
    210                 215                 220                 


Ile Thr Ser Leu Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
225                 230                 235                 240 


Tyr Trp Ser Thr Pro Val Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
                245                 250                 255     


Lys Ala Ala Ala 
            260 


<210>  22
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn 
65                  70                  75                  80  


Phe Asn Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Ala Tyr Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Ile 
145                 150                 155                 160 


Thr Ala Ala Ser Leu Gly Gln Lys Val Thr Ile Thr Cys Ser Ala Ser 
                165                 170                 175     


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
            180                 185                 190         


Pro Lys Pro Trp Ile Tyr Glu Ile Ser Lys Leu Ala Ser Gly Val Pro 
        195                 200                 205             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    210                 215                 220                 


Ser Ser Met Glu Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Trp 
225                 230                 235                 240 


Asn Tyr Pro Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Ala Ala Ala 
            


