                               SEQUENCE LISTING

<110> HARPOON THERAPEUTICS, INC.
 
<120> TARGETED CHECKPOINT INHIBITORS AND METHODS OF USE

<130> 47517-714.601

<140> PCT/US2018/020185
<141> 2018-02-28

<150> 62/464,982
<151> 2017-02-28

<160> 51    

<170> PatentIn version 3.5

<210> 1
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 1
Lys Arg Ala Leu Gly Leu Pro Gly 
1               5               


<210> 2
<211> 40
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 2
Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu 
1               5                   10                  15      


Arg Pro Leu Ala Leu Trp Arg Ser Asp Arg Asp Arg Asp Arg Asp Arg 
            20                  25                  30          


Asp Arg Asp Arg Asp Arg Asp Arg 
        35                  40  


<210> 3
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Ser or Thr

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ser or Thr

<400> 3
Pro Arg Xaa Xaa Xaa 
1               5   


<210> 4
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 4
Leu Glu Ala Thr Ala 
1               5   


<210> 5
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 5
Gly Gly Ala Ala Asn Leu Val Arg Gly Gly 
1               5                   10  


<210> 6
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 6
Ser Gly Arg Ile Gly Phe Leu Arg Thr Ala 
1               5                   10  


<210> 7
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 7
Pro Leu Gly Leu Ala Gly 
1               5       


<210> 8
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 8
Pro Leu Gly Leu Ala Xaa 
1               5       


<210> 9
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 9
Pro Leu Gly Cys Ala Gly 
1               5       


<210> 10
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 10
Glu Ser Pro Ala Tyr Tyr Thr Ala 
1               5               


<210> 11
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 11
Arg Leu Gln Leu Lys Leu 
1               5       


<210> 12
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 12
Arg Leu Gln Leu Lys Ala Cys 
1               5           


<210> 13
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Cit

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Hof

<400> 13
Glu Pro Xaa Gly Xaa Tyr Leu 
1               5           


<210> 14
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 14
Ser Gly Arg Ser Ala 
1               5   


<210> 15
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 15
Asp Ala Phe Lys 
1               


<210> 16
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 16
Gly Gly Gly Arg Arg 
1               5   


<210> 17
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 17
Gly Phe Leu Gly 
1               


<210> 18
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 18
Ala Leu Ala Leu 
1               


<210> 19
<211> 2
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 19
Phe Lys 
1       


<210> 20
<211> 3
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 20
Asn Leu Leu 
1           


<210> 21
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 21
Pro Ile Cys Phe Phe 
1               5   


<210> 22
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 22
Gly Gly Pro Arg Gly Leu Pro Gly 
1               5               


<210> 23
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 23
His Ser Ser Lys Leu Gln 
1               5       


<210> 24
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 24
His Ser Ser Lys Leu Gln Leu 
1               5           


<210> 25
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 25
His Ser Ser Lys Leu Gln Glu Asp Ala 
1               5                   


<210> 26
<211> 10
<212> PRT
<213> Herpes Simplex Virus

<400> 26
Leu Val Leu Ala Ser Ser Ser Phe Gly Tyr 
1               5                   10  


<210> 27
<211> 10
<212> PRT
<213> Human immunodeficiency virus

<400> 27
Gly Val Ser Gln Asn Tyr Pro Ile Val Gly 
1               5                   10  


<210> 28
<211> 10
<212> PRT
<213> Cytomegalovirus

<400> 28
Gly Val Val Gln Ala Ser Cys Arg Leu Ala 
1               5                   10  


<210> 29
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Pip

<400> 29
Phe Xaa Arg Ser 
1               


<210> 30
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 30
Asp Pro Arg Ser Phe Leu 
1               5       


<210> 31
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 31
Pro Pro Arg Ser Phe Leu 
1               5       


<210> 32
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 32
Asp Glu Val Asp 
1               


<210> 33
<211> 5
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 33
Asp Glu Val Asp Pro 
1               5   


<210> 34
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 34
Lys Gly Ser Gly Asp Val Glu Gly 
1               5               


<210> 35
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 35
Gly Trp Glu His Asp Gly 
1               5       


<210> 36
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 36
Glu Asp Asp Asp Asp Lys Ala 
1               5           


<210> 37
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 37
Lys Gln Glu Gln Asn Pro Gly Ser Thr 
1               5                   


<210> 38
<211> 6
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 38
Gly Lys Ala Phe Arg Arg 
1               5       


<210> 39
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 39
Asp Ala Phe Lys 
1               


<210> 40
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 40
Asp Val Leu Lys 
1               


<210> 41
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 41
Asp Ala Phe Lys 
1               


<210> 42
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Protease cleavage domain sequence

<400> 42
Ala Leu Leu Leu Ala Leu Leu 
1               5           


<210> 43
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(20)
<223> This sequence may encompass 1-10 'Gly Ser' 
      repeating units

<400> 43
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210> 44
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(30)
<223> This sequence may encompass 1-10 'Gly Gly Ser' 
      repeating units

<400> 44
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  25                  30  


<210> 45
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(40)
<223> This sequence may encompass 1-10 'Gly Gly Gly Ser' 
      repeating units

<400> 45
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40  


<210> 46
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(40)
<223> This sequence may encompass 1-10 'Gly Gly Ser Gly' 
      repeating units

<400> 46
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly 
        35                  40  


<210> 47
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(50)
<223> This sequence may encompass 1-10 'Gly Gly Ser Gly Gly' 
      repeating units

<400> 47
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly 
    50  


<210> 48
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(50)
<223> This sequence may encompass 1-10 'Gly Gly Gly Gly Ser' 
      repeating units

<400> 48
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210> 49
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 51
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 51
His His His His His His 
1               5       


