                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  GENE EDITING AND TRANSGENE FREE MUTANT PLANTS

<130>  00015-328WO1

<140>  Not yet assigned
<141>  2018-03-07

<150>  US 62/468,301
<151>  2017-03-07

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer ABP1-U409

<400>  1
cctcatcaca caacaaagtc actc                                              24


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer ABP1-CRP2-GT2

<400>  2
catgaggacc tgcaggtgtt g                                                 21


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer ABP1-2E

<400>  3
ttgccaatcg tgaggaatat tag                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRP2 partial sequence wiht BsaJ1 site

<400>  4
gaaacacatg gaaatttccc tgg                                               23


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRP3 partial sequence with TaqI site

<400>  5
ccaatcgaat ttccaatctt tgc                                               23


<210>  6
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Abp1 wild-type target site

<400>  6
gctgaaacac atggaaattt ccctggg                                           27


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  abp1-c4d mutant

<400>  7
gctgaaacac atggaaattt ggg                                               23


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  abp1-c3d mutant

<400>  8
gctgaaacac atggaaattt tggg                                              24


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  abp1 target sequence

<400>  9
tggaaatttc cctgggaa                                                     18


<210>  10
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  abp1-c8i mutant

<400>  10
tggaatttcc atagcactcc tggaaa                                            26


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  abp1 target sequence

<400>  11
accaatcgaa tttccaatct ttgcc                                             25


<210>  12
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  abp1-c12d mutant

<400>  12
accaatcttt gcc                                                          13


<210>  13
<211>  15444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHDE-335SCas9-mCherry vector


<220>
<221>  CDS
<222>  (505)..(1197)

<220>
<221>  CDS
<222>  (3993)..(8132)

<220>
<221>  CDS
<222>  (9428)..(10222)

<400>  13
gtttacccgc caatatatcc tgtcaaacac tgatagttta aactagtgaa gtgaagcttg       60

gtctcaacta tgagacctaa gctggcacaa ctatatttcc aacatcacta gctaccatca      120

aaagattgac ttctcatctt actcgattga aaccaaatta acatagggtt tttatttaaa      180

taaaagttta accttctttt taaaaaattg ttcatagtgt catgtcagaa caagagctac      240

aaatcacaca tagcatgcat aagcggagct atgatgagtg gtattgtttt gttcgtcact      300

tgtcactctt ttccaacaca taatcccgac aacaacgtaa gagcatctct ctctctccac      360

acacactcat gcatgcatgc attcttacac gtgattgcca tgcaaatctc ctttctcacc      420

tataaataca aaccaaccct tcactacact cttcactcaa accaaaacaa gaaaacatac      480

acaaatagca aaacggtacc aaca atg gat aac atg gcc atc atc aag gag         531
                           Met Asp Asn Met Ala Ile Ile Lys Glu            
                           1               5                              

ttc atg cgc ttc aag gtg cac atg gag ggc tcc gtg aac ggc cac gag        579
Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu           
10                  15                  20                  25            

ttc gag atc gag ggc gag ggc gag ggc cgc ccc tac gag ggc acc cag        627
Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln           
                30                  35                  40                

acc gcc aag ctg aag gtg acc aag ggt ggc ccc ctg ccc ttc gcc tgg        675
Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp           
            45                  50                  55                    

gac atc ctg tcc cct cag ttc atg tac ggc tcc aag gcc tac gtg aag        723
Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys           
        60                  65                  70                        

cac ccc gcc gac atc ccc gac tac ttg aag ctg tcc ttc ccc gag ggc        771
His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly           
    75                  80                  85                            

ttc aag tgg gag cgc gtg atg aac ttc gag gac ggc ggc gtg gtg acc        819
Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr           
90                  95                  100                 105           

gtg acc cag gac tcc tcc ctg cag gac ggc gag ttc atc tac aag gtg        867
Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val           
                110                 115                 120               

aag ctg cgc ggc acc aac ttc ccc tcc gac ggc ccc gta atg cag aag        915
Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys           
            125                 130                 135                   

aag acc atg ggc tgg gag gcc tcc tcc gag cgg atg tac ccc gag gac        963
Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp           
        140                 145                 150                       

ggc gcc ctg aag ggc gag atc aag cag agg ctg aag ctg aag gac ggc       1011
Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly           
    155                 160                 165                           

ggc cac tac gac gct gag gtc aag acc acc tac aag gcc aag aag ccc       1059
Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro           
170                 175                 180                 185           

gtg cag ctg ccc ggc gcc tac aac gtc aac atc aag ttg gac atc acc       1107
Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr           
                190                 195                 200               

tcc cac aac gag gac tac acc atc gtg gaa cag tac gaa cgc gcc gag       1155
Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu           
            205                 210                 215                   

ggc cgc cac tcc acc ggc ggc atg gac gag ctg tac aag tga               1197
Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys                       
        220                 225                 230                       

gagctcttgg actcccatgt tggcaaaggc aaccaaacaa acaatgaatg atccgctcct     1257

gcatatgggg cggtttgagt atttcaactg ccatttgggc tgaattgaag acatgctcct     1317

gtcagaaatt ccgtgatctt actcaatatt cagtaatctc ggccaatatc ctaaatgtgc     1377

gtggctttat ctgtctttgt attgtttcat caattcatgt aacgtttgct tttcttatga     1437

attttcaaat aaattatcgt attgagaccg aattctcgtc tagacctaac tgagtaagct     1497

agcttgttcg agtattatgg cattgggaaa actgtttttc ttgtaccatt tgttgtgctt     1557

gtaatttact gtgtttttta ttcggttttc gctatcgaac tgtgaaatgg aaatggatgg     1617

agaagagtta atgaatgata tggtcctttt gttcattctc aaattaatat tatttgtttt     1677

ttctcttatt tgttgtgtgt tgaatttgaa attataagag atatgcaaac attttgtttt     1737

gagtaaaaat gtgtcaaatc gtggcctcta atgaccgaag ttaatatgag gagtaaaaca     1797

ctagatcccc aaacaagctt gaaactgaag gcgggaaacg acaatctgat catgagcgga     1857

gaattaaggg agtcacgtta tgacccccgc cgatgacgcg ggacaagccg ttttacgttt     1917

ggaactgaca gaaccgcaac gttgaaggag ccactcagcc gcgggtttct ggagtttaat     1977

gagctaagca catacgtcag aaaccattat tgcgcgttca aaagtcgcct aaggtcacta     2037

tcagctagca aatatttctt gtcaaaaatg ctccactgac gttccataaa ttcccctcgg     2097

tatccaatta gagtctcata ttcactctca atccaaataa tctgcaccgg atccgctaga     2157

ggatctcgac ctgcaagatc ccggggggca atgagatatg aaaaagcctg aactcaccgc     2217

gacgtctgtc gagaagtttc tgatcgaaaa gttcgacagc gtctccgacc tgatgcagct     2277

ctcggagggc gaagaatctc gtgctttcag cttcgatata ggagggcgtg gatatgtcct     2337

gcgggtaaat agctgcgccg atggtttcta caaagatcgt tatgtttatc ggcactttgc     2397

atcggccgcg ctcccgattc cggaagtgct tgacattggg gaattcagcg agagcctgac     2457

ctattgcatc tcccgccgtg cacagggtgt cacgttgcaa gacctgcctg aaaccgaact     2517

gcccgctgtt ctgcagccgg tcgcggaggc catggatgcg atcgctgcgg ccgatcttag     2577

ccagacgagc gggttcggcc cattcggacc gcaaggaatc ggtcaataca ctacatggcg     2637

tgatttcata tgcgcgattg ctgatcccca tgtgtatcac tggcaaactg tgatggacga     2697

caccgtcagt gcgtccgtcg cgcaggctct cgatgagctg atgctttggg ccgaggactg     2757

ccccgaagtc cggcacctcg tgcacgcgga tttcggctcc aacaatgtcc tgacggacaa     2817

tggccgcata acagcggtca ttgactggag cgaggcgatg ttcggggatt cccaatacga     2877

ggtcgccaac atcttcttct ggaggccgtg gttggcttgt atggagcagc agacgcgcta     2937

cttcgagcgg aggcatccgg agcttgcagg atcgccgcgg ctccgggcgt atatgctccg     2997

cattggtctt gaccaactct atcagagctt ggttgacggc aatttcgatg atgcagcttg     3057

ggcgcagggt cgatgcgacg caatcgtccg atccggagcc gggactgtcg ggcgtacaca     3117

aatcgcccgc agaagcgcgg ccgtctggac cgatggctgt gtagaagtac tcgccgatag     3177

tggaaaccga cgccccagca ctcgtccggg atcttggagg tgatgtaaca tgatcacaag     3237

ctgatccccc gaatttcccc gatcgttcaa acatttggca ataaagtttc ttaagattga     3297

atcctgttgc cggtcttgcg atgattatca tataatttct gttgaattac gttaagcatg     3357

taataattaa catgtaatgc atgacgttat ttatgagatg ggtttttatg attagagtcc     3417

cgcaattata catttaatac gcgatagaaa acaaaatata gcgcgcaaac taggataaat     3477

tatcgcgcgc ggtgtcatct atgttactag atcgggaatt gatcccccct cgacagcttg     3537

catgccagct tgggctgcag gtcgacgcgt caacatggtg gagcacgaca ctctcgtcta     3597

ctccaagaat atcaaagata cagtctcaga agaccaaagg gctattgaga cttttcaaca     3657

aagggtaata tcgggaaacc tcctcggatt ccattgccca gctatctgtc acttcatcaa     3717

aaggacagta gaaaaggaag gtggcaccta caaatgccat cattgcgata aaggaaaggc     3777

tatcgttcaa gatgcctctg ccgacagtgg tcccaaagat ggacccccac ccacgaggag     3837

catcgtggaa aaagaagacg ttccaaccac gtcttcaaag caagtggatt gatgtgatat     3897

ctccactgac gtaagggatg acgcacaatc ccactatcct tcgcaagacc cttcctctat     3957

ataaggaagt tcatttcatt tggagaggac acgat atg gac aag aag tac tcc        4010
                                       Met Asp Lys Lys Tyr Ser            
                                                       235                

att ggg ctc gat atc ggc aca aac agc gtc ggc tgg gcc gtc att acg       4058
Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr           
            240                 245                 250                   

gac gag tac aag gtg ccg agc aaa aaa ttc aaa gtt ctg ggc aat acc       4106
Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr           
        255                 260                 265                       

gat cgc cac agc ata aag aag aac ctc att ggc gcc ctc ctg ttc gac       4154
Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp           
    270                 275                 280                           

tcc ggg gag acg gcc gaa gcc acg cgg ctc aaa aga aca gca cgg cgc       4202
Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg           
285                 290                 295                 300           

aga tat acc cgc aga aag aat cgg atc tgc tac ctg cag gag atc ttt       4250
Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe           
                305                 310                 315               

agt aat gag atg gct aag gtg gat gac tct ttc ttc cat agg ctg gag       4298
Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu           
            320                 325                 330                   

gag tcc ttt ttg gtg gag gag gat aaa aag cac gag cgc cac cca atc       4346
Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile           
        335                 340                 345                       

ttt ggc aat atc gtg gac gag gtg gcg tac cat gaa aag tac cca acc       4394
Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr           
    350                 355                 360                           

ata tat cat ctg agg aag aag ctt gta gac agt act gat aag gct gac       4442
Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp           
365                 370                 375                 380           

ttg cgg ttg atc tat ctc gcg ctg gcg cat atg atc aaa ttt cgg gga       4490
Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly           
                385                 390                 395               

cac ttc ctc atc gag ggg gac ctg aac cca gac aac agc gat gtc gac       4538
His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp           
            400                 405                 410                   

aaa ctc ttt atc caa ctg gtt cag act tac aat cag ctt ttc gaa gag       4586
Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu           
        415                 420                 425                       

aac ccg atc aac gca tcc gga gtt gac gcc aaa gca atc ctg agc gct       4634
Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala           
    430                 435                 440                           

agg ctg tcc aaa tcc cgg cgg ctc gaa aac ctc atc gca cag ctc cct       4682
Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro           
445                 450                 455                 460           

ggg gag aag aag aac ggc ctg ttt ggt aat ctt atc gcc ctg tca ctc       4730
Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu           
                465                 470                 475               

ggg ctg acc ccc aac ttt aaa tct aac ttc gac ctg gcc gaa gat gcc       4778
Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala           
            480                 485                 490                   

aag ctt caa ctg agc aaa gac acc tac gat gat gat ctc gac aat ctg       4826
Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu           
        495                 500                 505                       

ctg gcc cag atc ggc gac cag tac gca gac ctt ttt ttg gcg gca aag       4874
Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys           
    510                 515                 520                           

aac ctg tca gac gcc att ctg ctg agt gat att ctg cga gtg aac acg       4922
Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr           
525                 530                 535                 540           

gag atc acc aaa gct ccg ctg agc gct agt atg atc aag cgc tat gat       4970
Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp           
                545                 550                 555               

gag cac cac caa gac ttg act ttg ctg aag gcc ctt gtc aga cag caa       5018
Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln           
            560                 565                 570                   

ctg cct gag aag tac aag gaa att ttc ttc gat cag tct aaa aat ggc       5066
Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly           
        575                 580                 585                       

tac gcc gga tac att gac ggc gga gca agc cag gag gaa ttt tac aaa       5114
Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys           
    590                 595                 600                           

ttt att aag ccc atc ttg gaa aaa atg gac ggc acc gag gag ctg ctg       5162
Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu           
605                 610                 615                 620           

gta aag ctt aac aga gaa gat ctg ttg cgc aaa cag cgc act ttc gac       5210
Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp           
                625                 630                 635               

aat gga agc atc ccc cac cag att cac ctg ggc gaa ctg cac gct atc       5258
Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile           
            640                 645                 650                   

ctc agg cgg caa gag gat ttc tac ccc ttt ttg aaa gat aac agg gaa       5306
Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu           
        655                 660                 665                       

aag att gag aaa atc ctc aca ttt cgg ata ccc tac tat gta ggc ccc       5354
Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro           
    670                 675                 680                           

ctc gcc cgg gga aat tcc aga ttc gcg tgg atg act cgc aaa tca gaa       5402
Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu           
685                 690                 695                 700           

gag acc atc act ccc tgg aac ttc gag gaa gtc gtg gat aag ggg gcc       5450
Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala           
                705                 710                 715               

tct gcc cag tcc ttc atc gaa agg atg act aac ttt gat aaa aat ctg       5498
Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu           
            720                 725                 730                   

cct aac gaa aag gtg ctt cct aaa cac tct ctg ctg tac gag tac ttc       5546
Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe           
        735                 740                 745                       

aca gtt tat aac gag ctc acc aag gtc aaa tac gtc aca gaa ggg atg       5594
Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met           
    750                 755                 760                           

aga aag cca gca ttc ctg tct gga gag cag aag aaa gct atc gtg gac       5642
Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp           
765                 770                 775                 780           

ctc ctc ttc aag acg aac cgg aaa gtt acc gtg aaa cag ctc aaa gaa       5690
Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu           
                785                 790                 795               

gac tat ttc aaa aag att gaa tgt ttc gac tct gtt gaa atc agc gga       5738
Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly           
            800                 805                 810                   

gtg gag gat cgc ttc aac gca tcc ctg gga acg tat cac gat ctc ctg       5786
Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu           
        815                 820                 825                       

aaa atc att aaa gac aag gac ttc ctg gac aat gag gag aac gag gac       5834
Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp           
    830                 835                 840                           

att ctt gag gac att gtc ctc acc ctt acg ttg ttt gaa gat agg gag       5882
Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu           
845                 850                 855                 860           

atg att gaa gaa cgc ttg aaa act tac gct cat ctc ttc gac gac aaa       5930
Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys           
                865                 870                 875               

gtc atg aaa cag ctc aag agg cgc cga tat aca gga tgg ggg cgg ctg       5978
Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu           
            880                 885                 890                   

tca aga aaa ctg atc aat ggg atc cga gac aag cag agt gga aag aca       6026
Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr           
        895                 900                 905                       

atc ctg gat ttt ctt aag tcc gat gga ttt gcc aac cgg aac ttc atg       6074
Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met           
    910                 915                 920                           

cag ttg atc cat gat gac tct ctc acc ttt aag gag gac atc cag aaa       6122
Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys           
925                 930                 935                 940           

gca caa gtt tct ggc cag ggg gac agt ctt cac gag cac atc gct aat       6170
Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn           
                945                 950                 955               

ctt gca ggt agc cca gct atc aaa aag gga ata ctg cag acc gtt aag       6218
Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys           
            960                 965                 970                   

gtc gtg gat gaa ctc gtc aaa gta atg gga agg cat aag ccc gag aat       6266
Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn           
        975                 980                 985                       

atc gtt atc gag atg gcc cga gag aac caa act acc  cag aag gga cag      6314
Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr  Gln Lys Gly Gln          
    990                 995                 1000                          

aag  aac agt agg gaa agg  atg aag agg att gaa  gag ggt ata aaa        6359
Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys            
1005                 1010                 1015                            

gaa  ctg ggg tcc caa atc  ctt aag gaa cac cca  gtt gaa aac acc        6404
Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr            
1020                 1025                 1030                            

cag  ctt cag aat gag aag  ctc tac ctg tac tac  ctg cag aac ggc        6449
Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly            
1035                 1040                 1045                            

agg  gac atg tac gtg gat  cag gaa ctg gac atc  aat cgg ctc tcc        6494
Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser            
1050                 1055                 1060                            

gac  tac gac gtg gat cat  atc gtg ccc cag tct  ttt ctc aaa gat        6539
Asp  Tyr Asp Val Asp His  Ile Val Pro Gln Ser  Phe Leu Lys Asp            
1065                 1070                 1075                            

gat  tct att gat aat aaa  gtg ttg aca aga tcc  gat aaa aat aga        6584
Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg            
1080                 1085                 1090                            

ggg  aag agt gat aac gtc  ccc tca gaa gaa gtt  gtc aag aaa atg        6629
Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met            
1095                 1100                 1105                            

aaa  aat tat tgg cgg cag  ctg ctg aac gcc aaa  ctg atc aca caa        6674
Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln            
1110                 1115                 1120                            

cgg  aag ttc gat aat ctg  act aag gct gaa cga  ggt ggc ctg tct        6719
Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser            
1125                 1130                 1135                            

gag  ttg gat aaa gcc ggc  ttc atc aaa agg cag  ctt gtt gag aca        6764
Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr            
1140                 1145                 1150                            

cgc  cag atc acc aag cac  gtg gcc caa att ctc  gat tca cgc atg        6809
Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met            
1155                 1160                 1165                            

aac  acc aag tac gat gaa  aat gac aaa ctg att  cga gag gtg aaa        6854
Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys            
1170                 1175                 1180                            

gtt  att act ctg aag tct  aag ctg gtc tca gat  ttc aga aag gac        6899
Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp            
1185                 1190                 1195                            

ttt  cag ttt tat aag gtg  aga gag atc aac aat  tac cac cat gcg        6944
Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala            
1200                 1205                 1210                            

cat  gat gcc tac ctg aat  gca gtg gta ggc act  gca ctt atc aaa        6989
His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys            
1215                 1220                 1225                            

aaa  tat ccc aag ctt gaa  tct gaa ttt gtt tac  gga gac tat aaa        7034
Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys            
1230                 1235                 1240                            

gtg  tac gat gtt agg aaa  atg atc gca aag tct  gag cag gaa ata        7079
Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile            
1245                 1250                 1255                            

ggc  aag gcc acc gct aag  tac ttc ttt tac agc  aat att atg aat        7124
Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn            
1260                 1265                 1270                            

ttt  ttc aag acc gag att  aca ctg gcc aat gga  gag att cgg aag        7169
Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys            
1275                 1280                 1285                            

cga  cca ctt atc gaa aca  aac gga gaa aca gga  gaa atc gtg tgg        7214
Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp            
1290                 1295                 1300                            

gac  aag ggt agg gat ttc  gcg aca gtc cgg aag  gtc ctg tcc atg        7259
Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met            
1305                 1310                 1315                            

ccg  cag gtg aac atc gtt  aaa aag acc gaa gta  cag acc gga ggc        7304
Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly            
1320                 1325                 1330                            

ttc  tcc aag gaa agt atc  ctc ccg aaa agg aac  agc gac aag ctg        7349
Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu            
1335                 1340                 1345                            

atc  gca cgc aaa aaa gat  tgg gac ccc aag aaa  tac ggc gga ttc        7394
Ile  Ala Arg Lys Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe            
1350                 1355                 1360                            

gat  tct cct aca gtc gct  tac agt gta ctg gtt  gtg gcc aaa gtg        7439
Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val            
1365                 1370                 1375                            

gag  aaa ggg aag tct aaa  aaa ctc aaa agc gtc  aag gaa ctg ctg        7484
Glu  Lys Gly Lys Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu            
1380                 1385                 1390                            

ggc  atc aca atc atg gag  cga tca agc ttc gaa  aaa aac ccc atc        7529
Gly  Ile Thr Ile Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile            
1395                 1400                 1405                            

gac  ttt ctc gag gcg aaa  gga tat aaa gag gtc  aaa aaa gac ctc        7574
Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu            
1410                 1415                 1420                            

atc  att aag ctt ccc aag  tac tct ctc ttt gag  ctt gaa aac ggc        7619
Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly            
1425                 1430                 1435                            

cgg  aaa cga atg ctc gct  agt gcg ggc gag ctg  cag aaa ggt aac        7664
Arg  Lys Arg Met Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn            
1440                 1445                 1450                            

gag  ctg gca ctg ccc tct  aaa tac gtt aat ttc  ttg tat ctg gcc        7709
Glu  Leu Ala Leu Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala            
1455                 1460                 1465                            

agc  cac tat gaa aag ctc  aaa ggg tct ccc gaa  gat aat gag cag        7754
Ser  His Tyr Glu Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln            
1470                 1475                 1480                            

aag  cag ctg ttc gtg gaa  caa cac aaa cac tac  ctt gat gag atc        7799
Lys  Gln Leu Phe Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile            
1485                 1490                 1495                            

atc  gag caa ata agc gaa  ttc tcc aaa aga gtg  atc ctc gcc gac        7844
Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp            
1500                 1505                 1510                            

gct  aac ctc gat aag gtg  ctt tct gct tac aat  aag cac agg gat        7889
Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp            
1515                 1520                 1525                            

aag  ccc atc agg gag cag  gca gaa aac att atc  cac ttg ttt act        7934
Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr            
1530                 1535                 1540                            

ctg  acc aac ttg ggc gcg  cct gca gcc ttc aag  tac ttc gac acc        7979
Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr            
1545                 1550                 1555                            

acc  ata gac aga aag cgg  tac acc tct aca aag  gag gtc ctg gac        8024
Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp            
1560                 1565                 1570                            

gcc  aca ctg att cat cag  tca att acg ggg ctc  tat gaa aca aga        8069
Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg            
1575                 1580                 1585                            

atc  gac ctc tct cag ctc  ggt gga gac agc agg  gct gac ccc aag        8114
Ile  Asp Leu Ser Gln Leu  Gly Gly Asp Ser Arg  Ala Asp Pro Lys            
1590                 1595                 1600                            

aag  aag agg aag gtg tga tcgatccagg cctcccagct ttcgtccgta             8162
Lys  Lys Arg Lys Val                                                      
1605                                                                      

tcatcggttt cgacaacgtt cgtcaagttc aatgcatcag tttcattgcc cacacaccag     8222

aatcctacta agtttgagta ttatggcatt ggaaaagctg ttttcttcta tcatttgttc     8282

tgcttgtaat ttactgtgtt ctttcagttt ttgttttcgg acatcaaaat gcaaatggat     8342

ggataagagt taataaatga tatggtcctt ttgttcattc tcaaattatt attatctgtt     8402

gtttttactt taatgggttg aatttaagta agaaaggaac taacagtgtg atattaaggt     8462

gcaatgttag acatataaaa cagtctttca cctctctttg gttatgtctt gaattggttt     8522

gtttcttcac ttatctgtgt aatcaagttt actatgagtc tatgatcaag taattatgca     8582

atcaagttaa gtacagtata ggctttttgt gtcgaggggg taccgagtcg aggaattcac     8642

tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc     8702

ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc     8762

cttcccaaca gttgcgcagc ctgaatggcg ggtaccgagc tcgaattcaa ttcggcgtta     8822

attcagtaca ttaaaaacgt ccgcaatgtg ttattaagtt gtctaagcgt caatttgttt     8882

acaccacaat atatcctgcc accagccagc caacagctcc ccgaccggca gctcggcaca     8942

aaatcaccac tcgatacagg cagcccatca gtccgggacg gcgtcagcgg gagagccgtt     9002

gtaaggcggc agactttgct catgttaccg atgctattcg gaagaacggc aactaagctg     9062

ccgggtttga aacacggatg atctcgcgga gggtagcatg ttgattgtaa cgatgacaga     9122

gcgttgctgc ctgtgatcaa ttcgggcacg aacccagtgg acataagcct cgttcggttc     9182

gtaagctgta atgcaagtag cgtaactgcc gtcacgcaac tggtccagaa ccttgaccga     9242

acgcagcggt ggtaacggcg cagtggcggt tttcatggct tcttgttatg acatgttttt     9302

ttggggtaca gtctatgcct cgggcatcca agcagcaagc gcgttacgcc gtgggtcgat     9362

gtttgatgtt atggagcagc aacgatgtta cgcagcaggg cagtcgccct aaaacaaagt     9422

taaac atc  atg ggg gaa gcg gtg  atc gcc gaa gta tcg  act caa cta      9469
      Ile  Met Gly Glu Ala Val  Ile Ala Glu Val Ser  Thr Gln Leu          
      1610                 1615                 1620                      

tca gag  gta gtt ggc gtc atc  gag cgc cat ctc gaa  ccg acg ttg        9514
Ser Glu  Val Val Gly Val Ile  Glu Arg His Leu Glu  Pro Thr Leu            
    1625                 1630                 1635                        

ctg gcc  gta cat ttg tac ggc  tcc gca gtg gat ggc  ggc ctg aag        9559
Leu Ala  Val His Leu Tyr Gly  Ser Ala Val Asp Gly  Gly Leu Lys            
    1640                 1645                 1650                        

cca cac  agt gat att gat ttg  ctg gtt acg gtg acc  gta agg ctt        9604
Pro His  Ser Asp Ile Asp Leu  Leu Val Thr Val Thr  Val Arg Leu            
    1655                 1660                 1665                        

gat gaa  aca acg cgg cga gct  ttg atc aac gac ctt  ttg gaa act        9649
Asp Glu  Thr Thr Arg Arg Ala  Leu Ile Asn Asp Leu  Leu Glu Thr            
    1670                 1675                 1680                        

tcg gct  tcc cct gga gag agc  gag att ctc cgc gct  gta gaa gtc        9694
Ser Ala  Ser Pro Gly Glu Ser  Glu Ile Leu Arg Ala  Val Glu Val            
    1685                 1690                 1695                        

acc att  gtt gtg cac gac gac  atc att ccg tgg cgt  tat cca gct        9739
Thr Ile  Val Val His Asp Asp  Ile Ile Pro Trp Arg  Tyr Pro Ala            
    1700                 1705                 1710                        

aag cgc  gaa ctg caa ttt gga  gaa tgg cag cgc aat  gac att ctt        9784
Lys Arg  Glu Leu Gln Phe Gly  Glu Trp Gln Arg Asn  Asp Ile Leu            
    1715                 1720                 1725                        

gca ggt  atc ttc gag cca gcc  acg atc gac att gat  ctg gct atc        9829
Ala Gly  Ile Phe Glu Pro Ala  Thr Ile Asp Ile Asp  Leu Ala Ile            
    1730                 1735                 1740                        

ttg ctg  aca aaa gca aga gaa  cat agc gtt gcc ttg  gta ggt cca        9874
Leu Leu  Thr Lys Ala Arg Glu  His Ser Val Ala Leu  Val Gly Pro            
    1745                 1750                 1755                        

gcg gcg  gag gaa ctc ttt gat  ccg gtt cct gaa cag  gat cta ttt        9919
Ala Ala  Glu Glu Leu Phe Asp  Pro Val Pro Glu Gln  Asp Leu Phe            
    1760                 1765                 1770                        

gag gcg  cta aat gaa acc tta  acg cta tgg aac tcg  ccg ccc gac        9964
Glu Ala  Leu Asn Glu Thr Leu  Thr Leu Trp Asn Ser  Pro Pro Asp            
    1775                 1780                 1785                        

tgg gct  ggc gat gag cga aat  gta gtg ctt acg ttg  tcc cgc att       10009
Trp Ala  Gly Asp Glu Arg Asn  Val Val Leu Thr Leu  Ser Arg Ile            
    1790                 1795                 1800                        

tgg tac  agc gca gta acc ggc  aaa atc gcg ccg aag  gat gtc gct       10054
Trp Tyr  Ser Ala Val Thr Gly  Lys Ile Ala Pro Lys  Asp Val Ala            
    1805                 1810                 1815                        

gcc gac  tgg gca atg gag cgc  ctg ccg gcc cag tat  cag ccc gtc       10099
Ala Asp  Trp Ala Met Glu Arg  Leu Pro Ala Gln Tyr  Gln Pro Val            
    1820                 1825                 1830                        

ata ctt  gaa gct aga cag gct  tat ctt gga caa gaa  gaa gat cgc       10144
Ile Leu  Glu Ala Arg Gln Ala  Tyr Leu Gly Gln Glu  Glu Asp Arg            
    1835                 1840                 1845                        

ttg gcc  tcg cgc gca gat cag  ttg gaa gaa ttt gtc  cac tac gtg       10189
Leu Ala  Ser Arg Ala Asp Gln  Leu Glu Glu Phe Val  His Tyr Val            
    1850                 1855                 1860                        

aaa ggc  gag atc acc aag gta  gtc ggc aaa taa tgtctagcta             10232
Lys Gly  Glu Ile Thr Lys Val  Val Gly Lys                                 
    1865                 1870                                             

gaaattcgtt caagccgacg ccgcttcgcc ggcgttaact caagcgatta gatgcactaa    10292

gcacataatt gctcacagcc aaactatcag gtcaagtctg cttttattat ttttaagcgt    10352

gcataataag ccctacacaa attgggagat atatcatgca tgaccaaaat cccttaacgt    10412

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat    10472

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg    10532

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga    10592

gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac    10652

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt    10712

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag    10772

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc    10832

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag    10892

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca    10952

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt    11012

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc    11072

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc    11132

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc    11192

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgcct gatgcggtat    11252

tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct cagtacaatc    11312

tgctctgatg ccgcatagtt aagccagtat acactccgct atcgctacgt gactgggtca    11372

tggctgcgcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc    11432

cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt    11492

caccgtcatc accgaaacgc gcgaggcagg gtgccttgat gtgggcgccg gcggtcgagt    11552

ggcgacggcg cggcttgtcc gcgccctggt agattgcctg gccgtaggcc agccattttt    11612

gagcggccag cggccgcgat aggccgacgc gaagcggcgg ggcgtaggga gcgcagcgac    11672

cgaagggtag gcgctttttg cagctcttcg gctgtgcgct ggccagacag ttatgcacag    11732

gccaggcggg ttttaagagt tttaataagt tttaaagagt tttaggcgga aaaatcgcct    11792

tttttctctt ttatatcagt cacttacatg tgtgaccggt tcccaatgta cggctttggg    11852

ttcccaatgt acgggttccg gttcccaatg tacggctttg ggttcccaat gtacgtgcta    11912

tccacaggaa agagaccttt tcgacctttt tcccctgcta gggcaatttg ccctagcatc    11972

tgctccgtac attaggaacc ggcggatgct tcgccctcga tcaggttgcg gtagcgcatg    12032

actaggatcg ggccagcctg ccccgcctcc tccttcaaat cgtactccgg caggtcattt    12092

gacccgatca gcttgcgcac ggtgaaacag aacttcttga actctccggc gctgccactg    12152

cgttcgtaga tcgtcttgaa caaccatctg gcttctgcct tgcctgcggc gcggcgtgcc    12212

aggcggtaga gaaaacggcc gatgccggga tcgatcaaaa agtaatcggg gtgaaccgtc    12272

agcacgtccg ggttcttgcc ttctgtgatc tcgcggtaca tccaatcagc tagctcgatc    12332

tcgatgtact ccggccgccc ggtttcgctc tttacgatct tgtagcggct aatcaaggct    12392

tcaccctcgg ataccgtcac caggcggccg ttcttggcct tcttcgtacg ctgcatggca    12452

acgtgcgtgg tgtttaaccg aatgcaggtt tctaccaggt cgtctttctg ctttccgcca    12512

tcggctcgcc ggcagaactt gagtacgtcc gcaacgtgtg gacggaacac gcggccgggc    12572

ttgtctccct tcccttcccg gtatcggttc atggattcgg ttagatggga aaccgccatc    12632

agtaccaggt cgtaatccca cacactggcc atgccggccg gccctgcgga aacctctacg    12692

tgcccgtctg gaagctcgta gcggatcacc tcgccagctc gtcggtcacg cttcgacaga    12752

cggaaaacgg ccacgtccat gatgctgcga ctatcgcggg tgcccacgtc atagagcatc    12812

ggaacgaaaa aatctggttg ctcgtcgccc ttgggcggct tcctaatcga cggcgcaccg    12872

gctgccggcg gttgccggga ttctttgcgg attcgatcag cggccgcttg ccacgattca    12932

ccggggcgtg cttctgcctc gatgcgttgc cgctgggcgg cctgcgcggc cttcaacttc    12992

tccaccaggt catcacccag cgccgcgccg atttgtaccg ggccggatgg tttgcgaccg    13052

tcacgccgat tcctcgggct tgggggttcc agtgccattg cagggccggc agacaaccca    13112

gccgcttacg cctggccaac cgcccgttcc tccacacatg gggcattcca cggcgtcggt    13172

gcctggttgt tcttgatttt ccatgccgcc tcctttagcc gctaaaattc atctactcat    13232

ttattcattt gctcatttac tctggtagct gcgcgatgta ttcagatagc agctcggtaa    13292

tggtcttgcc ttggcgtacc gcgtacatct tcagcttggt gtgatcctcc gccggcaact    13352

gaaagttgac ccgcttcatg gctggcgtgt ctgccaggct ggccaacgtt gcagccttgc    13412

tgctgcgtgc gctcggacgg ccggcactta gcgtgtttgt gcttttgctc attttctctt    13472

tacctcatta actcaaatga gttttgattt aatttcagcg gccagcgcct ggacctcgcg    13532

ggcagcgtcg ccctcgggtt ctgattcaag aacggttgtg ccggcggcgg cagtgcctgg    13592

gtagctcacg cgctgcgtga tacgggactc aagaatgggc agctcgtacc cggccagcgc    13652

ctcggcaacc tcaccgccga tgcgcgtgcc tttgatcgcc cgcgacacga caaaggccgc    13712

ttgtagcctt ccatccgtga cctcaatgcg ctgcttaacc agctccacca ggtcggcggt    13772

ggcccatatg tcgtaagggc ttggctgcac cggaatcagc acgaagtcgg ctgccttgat    13832

cgcggacaca gccaagtccg ccgcctgggg cgctccgtcg atcactacga agtcgcgccg    13892

gccgatggcc ttcacgtcgc ggtcaatcgt cgggcggtcg atgccgacaa cggttagcgg    13952

ttgatcttcc cgcacggccg cccaatcgcg ggcactgccc tggggatcgg aatcgactaa    14012

cagaacatcg gccccggcga gttgcagggc gcgggctaga tgggttgcga tggtcgtctt    14072

gcctgacccg cctttctggt taagtacagc gataaccttc atgcgttccc cttgcgtatt    14132

tgtttattta ctcatcgcat catatacgca gcgaccgcat gacgcaagct gttttactca    14192

aatacacatc acctttttag acggcggcgc tcggtttctt cagcggccaa gctggccggc    14252

caggccgcca gcttggcatc agacaaaccg gccaggattt catgcagccg cacggttgag    14312

acgtgcgcgg gcggctcgaa cacgtacccg gccgcgatca tctccgcctc gatctcttcg    14372

gtaatgaaaa acggttcgtc ctggccgtcc tggtgcggtt tcatgcttgt tcctcttggc    14432

gttcattctc ggcggccgcc agggcgtcgg cctcggtcaa tgcgtcctca cggaaggcac    14492

cgcgccgcct ggcctcggtg ggcgtcactt cctcgctgcg ctcaagtgcg cggtacaggg    14552

tcgagcgatg cacgccaagc agtgcagccg cctctttcac ggtgcggcct tcctggtcga    14612

tcagctcgcg ggcgtgcgcg atctgtgccg gggtgagggt agggcggggg ccaaacttca    14672

cgcctcgggc cttggcggcc tcgcgcccgc tccgggtgcg gtcgatgatt agggaacgct    14732

cgaactcggc aatgccggcg aacacggtca acaccatgcg gccggccggc gtggtggtgt    14792

cggcccacgg ctctgccagg ctacgcaggc ccgcgccggc ctcctggatg cgctcggcaa    14852

tgtccagtag gtcgcgggtg ctgcgggcca ggcggtctag cctggtcact gtcacaacgt    14912

cgccagggcg taggtggtca agcatcctgg ccagctccgg gcggtcgcgc ctggtgccgg    14972

tgatcttctc ggaaaacagc ttggtgcagc cggccgcgtg cagttcggcc cgttggttgg    15032

tcaagtcctg gtcgtcggtg ctgacgcggg catagcccag caggccagcg gcggcgctct    15092

tgttcatggc gtaatgtctc cggttctagt cgcaagtatt ctactttatg cgactaaaac    15152

acgcgacaag aaaacgccag gaaaagggca gggcggcagc ctgtcgcgta acttaggact    15212

tgtgcgacat gtcgttttca gaagacggct gcactgaacg tcagaagccg actgcactat    15272

agcagcggag gggttggatc aaagtacttt aaagtacttt aaagtacttt aaagtacttt    15332

gatcccgagg ggaaccctgt ggttggcatg cacatacaaa tggacgaacg gataaacctt    15392

ttcacgccct tttaaatatc cgattattct aataaacgct cttttctctt ag            15444


<210>  14
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His 
1               5                   10                  15      


Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly 
            20                  25                  30          


Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr 
        35                  40                  45              


Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe 
    50                  55                  60                  


Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp 
65                  70                  75                  80  


Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met 
                85                  90                  95      


Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu 
            100                 105                 110         


Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe 
        115                 120                 125             


Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala 
    130                 135                 140                 


Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile 
145                 150                 155                 160 


Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val 
                165                 170                 175     


Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr 
            180                 185                 190         


Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr 
        195                 200                 205             


Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly 
    210                 215                 220                 


Met Asp Glu Leu Tyr Lys 
225                 230 


<210>  15
<211>  1379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210>  16
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Ile Met Gly Glu Ala Val Ile Ala Glu Val Ser Thr Gln Leu Ser Glu 
1               5                   10                  15      


Val Val Gly Val Ile Glu Arg His Leu Glu Pro Thr Leu Leu Ala Val 
            20                  25                  30          


His Leu Tyr Gly Ser Ala Val Asp Gly Gly Leu Lys Pro His Ser Asp 
        35                  40                  45              


Ile Asp Leu Leu Val Thr Val Thr Val Arg Leu Asp Glu Thr Thr Arg 
    50                  55                  60                  


Arg Ala Leu Ile Asn Asp Leu Leu Glu Thr Ser Ala Ser Pro Gly Glu 
65                  70                  75                  80  


Ser Glu Ile Leu Arg Ala Val Glu Val Thr Ile Val Val His Asp Asp 
                85                  90                  95      


Ile Ile Pro Trp Arg Tyr Pro Ala Lys Arg Glu Leu Gln Phe Gly Glu 
            100                 105                 110         


Trp Gln Arg Asn Asp Ile Leu Ala Gly Ile Phe Glu Pro Ala Thr Ile 
        115                 120                 125             


Asp Ile Asp Leu Ala Ile Leu Leu Thr Lys Ala Arg Glu His Ser Val 
    130                 135                 140                 


Ala Leu Val Gly Pro Ala Ala Glu Glu Leu Phe Asp Pro Val Pro Glu 
145                 150                 155                 160 


Gln Asp Leu Phe Glu Ala Leu Asn Glu Thr Leu Thr Leu Trp Asn Ser 
                165                 170                 175     


Pro Pro Asp Trp Ala Gly Asp Glu Arg Asn Val Val Leu Thr Leu Ser 
            180                 185                 190         


Arg Ile Trp Tyr Ser Ala Val Thr Gly Lys Ile Ala Pro Lys Asp Val 
        195                 200                 205             


Ala Ala Asp Trp Ala Met Glu Arg Leu Pro Ala Gln Tyr Gln Pro Val 
    210                 215                 220                 


Ile Leu Glu Ala Arg Gln Ala Tyr Leu Gly Gln Glu Glu Asp Arg Leu 
225                 230                 235                 240 


Ala Ser Arg Ala Asp Gln Leu Glu Glu Phe Val His Tyr Val Lys Gly 
                245                 250                 255     


Glu Ile Thr Lys Val Val Gly Lys 
            260                 


<210>  17
<211>  16671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHDE-35S-Cas9-mCherry-UBQ10 with U6 gRNA unit


<220>
<221>  misc_feature
<222>  (301)..(319)
<223>  N represents any nucleotide sequence corresponding to a gRNA 
       (guide RNA sequence)

<220>
<221>  CDS
<222>  (1094)..(1786)

<220>
<221>  CDS
<222>  (5220)..(9359)

<220>
<221>  CDS
<222>  (10658)..(11449)

<400>  17
gtttacccgc caatatatcc tgtcaaacac tgatagtttg tcccaggatt agaatgatta       60

ggcatcgaac cttcaagaat ttgattgaat aaaacatctt cattcttaag atatgaagat      120

aatcttcaaa aggcccctgg gaatctgaaa gaagagaagc aggcccattt atatgggaaa      180

gaacaatagt atttcttata taggcccatt taagttgaaa acaatcttca aaagtcccac      240

atcgcttaga taagaaaacg aagctgagtt tatatacagc tagagtcgaa gtagtgattg      300

nnnnnnnnnn nnnnnnnnng ttttagagct agaaatagca agttaaaata aggctagtcc      360

gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt tttgcaaaat tttccagatc      420

gatttcttct tcctctgttc ttcggcgttc aatttctggg gttttctctt cgttttctgt      480

aactgaaacc taaaatttga cctaaaaaaa atctcaaata atatgattca gtggttttgt      540

acttttcagt tagttgagtt ttgcagttcc gatgagataa accaataact ttgcttagat      600

ctaattcatt ccgttacacc tctgatggaa actagtgaag tgaagcttgg tctcaactat      660

gagacctaag ctggcacaac tatatttcca acatcactag ctaccatcaa aagattgact      720

tctcatctta ctcgattgaa accaaattaa catagggttt ttatttaaat aaaagtttaa      780

ccttcttttt aaaaaattgt tcatagtgtc atgtcagaac aagagctaca aatcacacat      840

agcatgcata agcggagcta tgatgagtgg tattgttttg ttcgtcactt gtcactcttt      900

tccaacacat aatcccgaca acaacgtaag agcatctctc tctctccaca cacactcatg      960

catgcatgca ttcttacacg tgattgccat gcaaatctcc tttctcacct ataaatacaa     1020

accaaccctt cactacactc ttcactcaaa ccaaaacaag aaaacataca caaatagcaa     1080

aacggtacca aca atg gat aac atg gcc atc atc aag gag ttc atg cgc        1129
               Met Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg            
               1               5                   10                     

ttc aag gtg cac atg gag ggc tcc gtg aac ggc cac gag ttc gag atc       1177
Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile           
        15                  20                  25                        

gag ggc gag ggc gag ggc cgc ccc tac gag ggc acc cag acc gcc aag       1225
Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys           
    30                  35                  40                            

ctg aag gtg acc aag ggt ggc ccc ctg ccc ttc gcc tgg gac atc ctg       1273
Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu           
45                  50                  55                  60            

tcc cct cag ttc atg tac ggc tcc aag gcc tac gtg aag cac ccc gcc       1321
Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala           
                65                  70                  75                

gac atc ccc gac tac ttg aag ctg tcc ttc ccc gag ggc ttc aag tgg       1369
Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp           
            80                  85                  90                    

gag cgc gtg atg aac ttc gag gac ggc ggc gtg gtg acc gtg acc cag       1417
Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln           
        95                  100                 105                       

gac tcc tcc ctg cag gac ggc gag ttc atc tac aag gtg aag ctg cgc       1465
Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg           
    110                 115                 120                           

ggc acc aac ttc ccc tcc gac ggc ccc gta atg cag aag aag acc atg       1513
Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met           
125                 130                 135                 140           

ggc tgg gag gcc tcc tcc gag cgg atg tac ccc gag gac ggc gcc ctg       1561
Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu           
                145                 150                 155               

aag ggc gag atc aag cag agg ctg aag ctg aag gac ggc ggc cac tac       1609
Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr           
            160                 165                 170                   

gac gct gag gtc aag acc acc tac aag gcc aag aag ccc gtg cag ctg       1657
Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu           
        175                 180                 185                       

ccc ggc gcc tac aac gtc aac atc aag ttg gac atc acc tcc cac aac       1705
Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn           
    190                 195                 200                           

gag gac tac acc atc gtg gaa cag tac gaa cgc gcc gag ggc cgc cac       1753
Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His           
205                 210                 215                 220           

tcc acc ggc ggc atg gac gag ctg tac aag tga gagctcttgg actcccatgt     1806
Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys                                   
                225                 230                                   

tggcaaaggc aaccaaacaa acaatgaatg atccgctcct gcatatgggg cggtttgagt     1866

atttcaactg ccatttgggc tgaattgaag acatgctcct gtcagaaatt ccgtgatctt     1926

actcaatatt cagtaatctc ggccaatatc ctaaatgtgc gtggctttat ctgtctttgt     1986

attgtttcat caattcatgt aacgtttgct tttcttatga attttcaaat aaattatcgt     2046

attgagaccg aattctcgtc gacgagtcag taataaacgg cgtcaaagtg gttgcagccg     2106

gcacacacga gtcgtgttta tcaactcaaa gcacaaatac ttttcctcaa cctaaaaata     2166

aggcaattag ccaaaaacaa ctttgcgtgt aaacaacgct caatacacgt gtcattttat     2226

tattagctat tgcttcaccg ccttagcttt ctcgtgacct agtcgtcctc gtcttttctt     2286

cttcttcttc tataaaacaa tacccaaaga gctcttcttc ttcacaattc agatttcaat     2346

ttctcaaaat cttaaaaact ttctctcaat tctctctacc gtgatcaagg taaatttctg     2406

tgttccttat tctctcaaaa tcttcgattt tgttttcgtt cgatcccaat ttcgtatatg     2466

ttctttggtt tagattctgt taatcttaga tcgaagacga ttttctgggt ttgatcgtta     2526

gatatcatct taattctcga ttagggtttc atagatatca tccgatttgt tcaaataatt     2586

tgagttttgt cgaataatta ctcttcgatt tgtgatttct atctagatct ggtgttagtt     2646

tctagtttgt gcgatcgaat ttgtcgatta atctgagttt ttctgattaa cagctcgcaa     2706

ttgacctaac tgagtaagct agcttgttcg agtattatgg cattgggaaa actgtttttc     2766

ttgtaccatt tgttgtgctt gtaatttact gtgtttttta ttcggttttc gctatcgaac     2826

tgtgaaatgg aaatggatgg agaagagtta atgaatgata tggtcctttt gttcattctc     2886

aaattaatat tatttgtttt ttctcttatt tgttgtgtgt tgaatttgaa attataagag     2946

atatgcaaac attttgtttt gagtaaaaat gtgtcaaatc gtggcctcta atgaccgaag     3006

ttaatatgag gagtaaaaca ctagatcccc aaacaagctt gaaactgaag gcgggaaacg     3066

acaatctgat catgagcgga gaattaaggg agtcacgtta tgacccccgc cgatgacgcg     3126

ggacaagccg ttttacgttt ggaactgaca gaaccgcaac gttgaaggag ccactcagcc     3186

gcgggtttct ggagtttaat gagctaagca catacgtcag aaaccattat tgcgcgttca     3246

aaagtcgcct aaggtcacta tcagctagca aatatttctt gtcaaaaatg ctccactgac     3306

gttccataaa ttcccctcgg tatccaatta gagtctcata ttcactctca atccaaataa     3366

tctgcaccgg atccgctaga ggatctcgac ctgcaagatc ccggggggca atgagatatg     3426

aaaaagcctg aactcaccgc gacgtctgtc gagaagtttc tgatcgaaaa gttcgacagc     3486

gtctccgacc tgatgcagct ctcggagggc gaagaatctc gtgctttcag cttcgatata     3546

ggagggcgtg gatatgtcct gcgggtaaat agctgcgccg atggtttcta caaagatcgt     3606

tatgtttatc ggcactttgc atcggccgcg ctcccgattc cggaagtgct tgacattggg     3666

gaattcagcg agagcctgac ctattgcatc tcccgccgtg cacagggtgt cacgttgcaa     3726

gacctgcctg aaaccgaact gcccgctgtt ctgcagccgg tcgcggaggc catggatgcg     3786

atcgctgcgg ccgatcttag ccagacgagc gggttcggcc cattcggacc gcaaggaatc     3846

ggtcaataca ctacatggcg tgatttcata tgcgcgattg ctgatcccca tgtgtatcac     3906

tggcaaactg tgatggacga caccgtcagt gcgtccgtcg cgcaggctct cgatgagctg     3966

atgctttggg ccgaggactg ccccgaagtc cggcacctcg tgcacgcgga tttcggctcc     4026

aacaatgtcc tgacggacaa tggccgcata acagcggtca ttgactggag cgaggcgatg     4086

ttcggggatt cccaatacga ggtcgccaac atcttcttct ggaggccgtg gttggcttgt     4146

atggagcagc agacgcgcta cttcgagcgg aggcatccgg agcttgcagg atcgccgcgg     4206

ctccgggcgt atatgctccg cattggtctt gaccaactct atcagagctt ggttgacggc     4266

aatttcgatg atgcagcttg ggcgcagggt cgatgcgacg caatcgtccg atccggagcc     4326

gggactgtcg ggcgtacaca aatcgcccgc agaagcgcgg ccgtctggac cgatggctgt     4386

gtagaagtac tcgccgatag tggaaaccga cgccccagca ctcgtccggg atcttggagg     4446

tgatgtaaca tgatcacaag ctgatccccc gaatttcccc gatcgttcaa acatttggca     4506

ataaagtttc ttaagattga atcctgttgc cggtcttgcg atgattatca tataatttct     4566

gttgaattac gttaagcatg taataattaa catgtaatgc atgacgttat ttatgagatg     4626

ggtttttatg attagagtcc cgcaattata catttaatac gcgatagaaa acaaaatata     4686

gcgcgcaaac taggataaat tatcgcgcgc ggtgtcatct atgttactag atcgggaatt     4746

gatcccccct cgacagcttg catgccagct tgggctgcag gtcgacgcgt caacatggtg     4806

gagcacgaca ctctcgtcta ctccaagaat atcaaagata cagtctcaga agaccaaagg     4866

gctattgaga cttttcaaca aagggtaata tcgggaaacc tcctcggatt ccattgccca     4926

gctatctgtc acttcatcaa aaggacagta gaaaaggaag gtggcaccta caaatgccat     4986

cattgcgata aaggaaaggc tatcgttcaa gatgcctctg ccgacagtgg tcccaaagat     5046

ggacccccac ccacgaggag catcgtggaa aaagaagacg ttccaaccac gtcttcaaag     5106

caagtggatt gatgtgatat ctccactgac gtaagggatg acgcacaatc ccactatcct     5166

tcgcaagacc cttcctctat ataaggaagt tcatttcatt tggagaggac acg atg        5222
                                                           Met            
                                                                          

gac aag aag tac tcc att ggg ctc gat atc ggc aca aac agc gtc ggc       5270
Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly           
            235                 240                 245                   

tgg gcc gtc att acg gac gag tac aag gtg ccg agc aaa aaa ttc aaa       5318
Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys           
        250                 255                 260                       

gtt ctg ggc aat acc gat cgc cac agc ata aag aag aac ctc att ggc       5366
Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly           
    265                 270                 275                           

gcc ctc ctg ttc gac tcc ggg gag acg gcc gaa gcc acg cgg ctc aaa       5414
Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys           
280                 285                 290                 295           

aga aca gca cgg cgc aga tat acc cgc aga aag aat cgg atc tgc tac       5462
Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr           
                300                 305                 310               

ctg cag gag atc ttt agt aat gag atg gct aag gtg gat gac tct ttc       5510
Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe           
            315                 320                 325                   

ttc cat agg ctg gag gag tcc ttt ttg gtg gag gag gat aaa aag cac       5558
Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His           
        330                 335                 340                       

gag cgc cac cca atc ttt ggc aat atc gtg gac gag gtg gcg tac cat       5606
Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His           
    345                 350                 355                           

gaa aag tac cca acc ata tat cat ctg agg aag aag ctt gta gac agt       5654
Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser           
360                 365                 370                 375           

act gat aag gct gac ttg cgg ttg atc tat ctc gcg ctg gcg cat atg       5702
Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met           
                380                 385                 390               

atc aaa ttt cgg gga cac ttc ctc atc gag ggg gac ctg aac cca gac       5750
Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp           
            395                 400                 405                   

aac agc gat gtc gac aaa ctc ttt atc caa ctg gtt cag act tac aat       5798
Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn           
        410                 415                 420                       

cag ctt ttc gaa gag aac ccg atc aac gca tcc gga gtt gac gcc aaa       5846
Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys           
    425                 430                 435                           

gca atc ctg agc gct agg ctg tcc aaa tcc cgg cgg ctc gaa aac ctc       5894
Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu           
440                 445                 450                 455           

atc gca cag ctc cct ggg gag aag aag aac ggc ctg ttt ggt aat ctt       5942
Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu           
                460                 465                 470               

atc gcc ctg tca ctc ggg ctg acc ccc aac ttt aaa tct aac ttc gac       5990
Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp           
            475                 480                 485                   

ctg gcc gaa gat gcc aag ctt caa ctg agc aaa gac acc tac gat gat       6038
Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp           
        490                 495                 500                       

gat ctc gac aat ctg ctg gcc cag atc ggc gac cag tac gca gac ctt       6086
Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu           
    505                 510                 515                           

ttt ttg gcg gca aag aac ctg tca gac gcc att ctg ctg agt gat att       6134
Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile           
520                 525                 530                 535           

ctg cga gtg aac acg gag atc acc aaa gct ccg ctg agc gct agt atg       6182
Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met           
                540                 545                 550               

atc aag cgc tat gat gag cac cac caa gac ttg act ttg ctg aag gcc       6230
Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala           
            555                 560                 565                   

ctt gtc aga cag caa ctg cct gag aag tac aag gaa att ttc ttc gat       6278
Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp           
        570                 575                 580                       

cag tct aaa aat ggc tac gcc gga tac att gac ggc gga gca agc cag       6326
Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln           
    585                 590                 595                           

gag gaa ttt tac aaa ttt att aag ccc atc ttg gaa aaa atg gac ggc       6374
Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly           
600                 605                 610                 615           

acc gag gag ctg ctg gta aag ctt aac aga gaa gat ctg ttg cgc aaa       6422
Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys           
                620                 625                 630               

cag cgc act ttc gac aat gga agc atc ccc cac cag att cac ctg ggc       6470
Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly           
            635                 640                 645                   

gaa ctg cac gct atc ctc agg cgg caa gag gat ttc tac ccc ttt ttg       6518
Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu           
        650                 655                 660                       

aaa gat aac agg gaa aag att gag aaa atc ctc aca ttt cgg ata ccc       6566
Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro           
    665                 670                 675                           

tac tat gta ggc ccc ctc gcc cgg gga aat tcc aga ttc gcg tgg atg       6614
Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met           
680                 685                 690                 695           

act cgc aaa tca gaa gag acc atc act ccc tgg aac ttc gag gaa gtc       6662
Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val           
                700                 705                 710               

gtg gat aag ggg gcc tct gcc cag tcc ttc atc gaa agg atg act aac       6710
Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn           
            715                 720                 725                   

ttt gat aaa aat ctg cct aac gaa aag gtg ctt cct aaa cac tct ctg       6758
Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu           
        730                 735                 740                       

ctg tac gag tac ttc aca gtt tat aac gag ctc acc aag gtc aaa tac       6806
Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr           
    745                 750                 755                           

gtc aca gaa ggg atg aga aag cca gca ttc ctg tct gga gag cag aag       6854
Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys           
760                 765                 770                 775           

aaa gct atc gtg gac ctc ctc ttc aag acg aac cgg aaa gtt acc gtg       6902
Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val           
                780                 785                 790               

aaa cag ctc aaa gaa gac tat ttc aaa aag att gaa tgt ttc gac tct       6950
Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser           
            795                 800                 805                   

gtt gaa atc agc gga gtg gag gat cgc ttc aac gca tcc ctg gga acg       6998
Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr           
        810                 815                 820                       

tat cac gat ctc ctg aaa atc att aaa gac aag gac ttc ctg gac aat       7046
Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn           
    825                 830                 835                           

gag gag aac gag gac att ctt gag gac att gtc ctc acc ctt acg ttg       7094
Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu           
840                 845                 850                 855           

ttt gaa gat agg gag atg att gaa gaa cgc ttg aaa act tac gct cat       7142
Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His           
                860                 865                 870               

ctc ttc gac gac aaa gtc atg aaa cag ctc aag agg cgc cga tat aca       7190
Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr           
            875                 880                 885                   

gga tgg ggg cgg ctg tca aga aaa ctg atc aat ggg atc cga gac aag       7238
Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys           
        890                 895                 900                       

cag agt gga aag aca atc ctg gat ttt ctt aag tcc gat gga ttt gcc       7286
Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala           
    905                 910                 915                           

aac cgg aac ttc atg cag ttg atc cat gat gac tct ctc acc ttt aag       7334
Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys           
920                 925                 930                 935           

gag gac atc cag aaa gca caa gtt tct ggc cag ggg gac agt ctt cac       7382
Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His           
                940                 945                 950               

gag cac atc gct aat ctt gca ggt agc cca gct atc aaa aag gga ata       7430
Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile           
            955                 960                 965                   

ctg cag acc gtt aag gtc gtg gat gaa ctc gtc aaa gta atg gga agg       7478
Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg           
        970                 975                 980                       

cat aag ccc gag aat atc gtt atc gag atg gcc cga gag aac caa act       7526
His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr           
    985                 990                 995                           

acc  cag aag gga cag aag  aac agt agg gaa agg  atg aag agg att        7571
Thr  Gln Lys Gly Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile            
1000                 1005                 1010                            

gaa  gag ggt ata aaa gaa  ctg ggg tcc caa atc  ctt aag gaa cac        7616
Glu  Glu Gly Ile Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His            
1015                 1020                 1025                            

cca  gtt gaa aac acc cag  ctt cag aat gag aag  ctc tac ctg tac        7661
Pro  Val Glu Asn Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr            
1030                 1035                 1040                            

tac  ctg cag aac ggc agg  gac atg tac gtg gat  cag gaa ctg gac        7706
Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp            
1045                 1050                 1055                            

atc  aat cgg ctc tcc gac  tac gac gtg gat cat  atc gtg ccc cag        7751
Ile  Asn Arg Leu Ser Asp  Tyr Asp Val Asp His  Ile Val Pro Gln            
1060                 1065                 1070                            

tct  ttt ctc aaa gat gat  tct att gat aat aaa  gtg ttg aca aga        7796
Ser  Phe Leu Lys Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg            
1075                 1080                 1085                            

tcc  gat aaa aat aga ggg  aag agt gat aac gtc  ccc tca gaa gaa        7841
Ser  Asp Lys Asn Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu            
1090                 1095                 1100                            

gtt  gtc aag aaa atg aaa  aat tat tgg cgg cag  ctg ctg aac gcc        7886
Val  Val Lys Lys Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala            
1105                 1110                 1115                            

aaa  ctg atc aca caa cgg  aag ttc gat aat ctg  act aag gct gaa        7931
Lys  Leu Ile Thr Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu            
1120                 1125                 1130                            

cga  ggt ggc ctg tct gag  ttg gat aaa gcc ggc  ttc atc aaa agg        7976
Arg  Gly Gly Leu Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg            
1135                 1140                 1145                            

cag  ctt gtt gag aca cgc  cag atc acc aag cac  gtg gcc caa att        8021
Gln  Leu Val Glu Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile            
1150                 1155                 1160                            

ctc  gat tca cgc atg aac  acc aag tac gat gaa  aat gac aaa ctg        8066
Leu  Asp Ser Arg Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu            
1165                 1170                 1175                            

att  cga gag gtg aaa gtt  att act ctg aag tct  aag ctg gtc tca        8111
Ile  Arg Glu Val Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser            
1180                 1185                 1190                            

gat  ttc aga aag gac ttt  cag ttt tat aag gtg  aga gag atc aac        8156
Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn            
1195                 1200                 1205                            

aat  tac cac cat gcg cat  gat gcc tac ctg aat  gca gtg gta ggc        8201
Asn  Tyr His His Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly            
1210                 1215                 1220                            

act  gca ctt atc aaa aaa  tat ccc aag ctt gaa  tct gaa ttt gtt        8246
Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val            
1225                 1230                 1235                            

tac  gga gac tat aaa gtg  tac gat gtt agg aaa  atg atc gca aag        8291
Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys            
1240                 1245                 1250                            

tct  gag cag gaa ata ggc  aag gcc acc gct aag  tac ttc ttt tac        8336
Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr            
1255                 1260                 1265                            

agc  aat att atg aat ttt  ttc aag acc gag att  aca ctg gcc aat        8381
Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn            
1270                 1275                 1280                            

gga  gag att cgg aag cga  cca ctt atc gaa aca  aac gga gaa aca        8426
Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr            
1285                 1290                 1295                            

gga  gaa atc gtg tgg gac  aag ggt agg gat ttc  gcg aca gtc cgg        8471
Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg            
1300                 1305                 1310                            

aag  gtc ctg tcc atg ccg  cag gtg aac atc gtt  aaa aag acc gaa        8516
Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu            
1315                 1320                 1325                            

gta  cag acc gga ggc ttc  tcc aag gaa agt atc  ctc ccg aaa agg        8561
Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg            
1330                 1335                 1340                            

aac  agc gac aag ctg atc  gca cgc aaa aaa gat  tgg gac ccc aag        8606
Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro Lys            
1345                 1350                 1355                            

aaa  tac ggc gga ttc gat  tct cct aca gtc gct  tac agt gta ctg        8651
Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu            
1360                 1365                 1370                            

gtt  gtg gcc aaa gtg gag  aaa ggg aag tct aaa  aaa ctc aaa agc        8696
Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys Ser            
1375                 1380                 1385                            

gtc  aag gaa ctg ctg ggc  atc aca atc atg gag  cga tca agc ttc        8741
Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser Phe            
1390                 1395                 1400                            

gaa  aaa aac ccc atc gac  ttt ctc gag gcg aaa  gga tat aaa gag        8786
Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys Glu            
1405                 1410                 1415                            

gtc  aaa aaa gac ctc atc  att aag ctt ccc aag  tac tct ctc ttt        8831
Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe            
1420                 1425                 1430                            

gag  ctt gaa aac ggc cgg  aaa cga atg ctc gct  agt gcg ggc gag        8876
Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly Glu            
1435                 1440                 1445                            

ctg  cag aaa ggt aac gag  ctg gca ctg ccc tct  aaa tac gtt aat        8921
Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val Asn            
1450                 1455                 1460                            

ttc  ttg tat ctg gcc agc  cac tat gaa aag ctc  aaa ggg tct ccc        8966
Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser Pro            
1465                 1470                 1475                            

gaa  gat aat gag cag aag  cag ctg ttc gtg gaa  caa cac aaa cac        9011
Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys His            
1480                 1485                 1490                            

tac  ctt gat gag atc atc  gag caa ata agc gaa  ttc tcc aaa aga        9056
Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg            
1495                 1500                 1505                            

gtg  atc ctc gcc gac gct  aac ctc gat aag gtg  ctt tct gct tac        9101
Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr            
1510                 1515                 1520                            

aat  aag cac agg gat aag  ccc atc agg gag cag  gca gaa aac att        9146
Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile            
1525                 1530                 1535                            

atc  cac ttg ttt act ctg  acc aac ttg ggc gcg  cct gca gcc ttc        9191
Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe            
1540                 1545                 1550                            

aag  tac ttc gac acc acc  ata gac aga aag cgg  tac acc tct aca        9236
Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr            
1555                 1560                 1565                            

aag  gag gtc ctg gac gcc  aca ctg att cat cag  tca att acg ggg        9281
Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly            
1570                 1575                 1580                            

ctc  tat gaa aca aga atc  gac ctc tct cag ctc  ggt gga gac agc        9326
Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp Ser            
1585                 1590                 1595                            

agg  gct gac ccc aag aag  aag agg aag gtg tga tcgatccagg              9369
Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val                                 
1600                 1605                                                 

cctcccagct ttcgtccgta tcatcggttt cgacaacgtt cgtcaagttc aatgcatcag     9429

tttcattgcc cacacaccag aatcctacta agtttgagta ttatggcatt ggaaaagctg     9489

ttttcttcta tcatttgttc tgcttgtaat ttactgtgtt ctttcagttt ttgttttcgg     9549

acatcaaaat gcaaatggat ggataagagt taataaatga tatggtcctt ttgttcattc     9609

tcaaattatt attatctgtt gtttttactt taatgggttg aatttaagta agaaaggaac     9669

taacagtgtg atattaaggt gcaatgttag acatataaaa cagtctttca cctctctttg     9729

gttatgtctt gaattggttt gtttcttcac ttatctgtgt aatcaagttt actatgagtc     9789

tatgatcaag taattatgca atcaagttaa gtacagtata ggctttttgt gtcgaggggg     9849

taccgagtcg aggaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg     9909

cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga     9969

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg ggtaccgagc    10029

tcgaattcaa ttcggcgtta attcagtaca ttaaaaacgt ccgcaatgtg ttattaagtt    10089

gtctaagcgt caatttgttt acaccacaat atatcctgcc accagccagc caacagctcc    10149

ccgaccggca gctcggcaca aaatcaccac tcgatacagg cagcccatca gtccgggacg    10209

gcgtcagcgg gagagccgtt gtaaggcggc agactttgct catgttaccg atgctattcg    10269

gaagaacggc aactaagctg ccgggtttga aacacggatg atctcgcgga gggtagcatg    10329

ttgattgtaa cgatgacaga gcgttgctgc ctgtgatcaa ttcgggcacg aacccagtgg    10389

acataagcct cgttcggttc gtaagctgta atgcaagtag cgtaactgcc gtcacgcaac    10449

tggtccagaa ccttgaccga acgcagcggt ggtaacggcg cagtggcggt tttcatggct    10509

tcttgttatg acatgttttt ttggggtaca gtctatgcct cgggcatcca agcagcaagc    10569

gcgttacgcc gtgggtcgat gtttgatgtt atggagcagc aacgatgtta cgcagcaggg    10629

cagtcgccct aaaacaaagt taaacatc atg  ggg gaa gcg gtg atc  gcc gaa     10681
                               Met  Gly Glu Ala Val Ile  Ala Glu          
                               1610                 1615                  

gta tcg act  caa cta tca gag gta  gtt ggc gtc atc gag  cgc cat       10726
Val Ser Thr  Gln Leu Ser Glu Val  Val Gly Val Ile Glu  Arg His            
        1620                 1625                 1630                    

ctc gaa ccg  acg ttg ctg gcc gta  cat ttg tac ggc tcc  gca gtg       10771
Leu Glu Pro  Thr Leu Leu Ala Val  His Leu Tyr Gly Ser  Ala Val            
        1635                 1640                 1645                    

gat ggc ggc  ctg aag cca cac agt  gat att gat ttg ctg  gtt acg       10816
Asp Gly Gly  Leu Lys Pro His Ser  Asp Ile Asp Leu Leu  Val Thr            
        1650                 1655                 1660                    

gtg acc gta  agg ctt gat gaa aca  acg cgg cga gct ttg  atc aac       10861
Val Thr Val  Arg Leu Asp Glu Thr  Thr Arg Arg Ala Leu  Ile Asn            
        1665                 1670                 1675                    

gac ctt ttg  gaa act tcg gct tcc  cct gga gag agc gag  att ctc       10906
Asp Leu Leu  Glu Thr Ser Ala Ser  Pro Gly Glu Ser Glu  Ile Leu            
        1680                 1685                 1690                    

cgc gct gta  gaa gtc acc att gtt  gtg cac gac gac atc  att ccg       10951
Arg Ala Val  Glu Val Thr Ile Val  Val His Asp Asp Ile  Ile Pro            
        1695                 1700                 1705                    

tgg cgt tat  cca gct aag cgc gaa  ctg caa ttt gga gaa  tgg cag       10996
Trp Arg Tyr  Pro Ala Lys Arg Glu  Leu Gln Phe Gly Glu  Trp Gln            
        1710                 1715                 1720                    

cgc aat gac  att ctt gca ggt atc  ttc gag cca gcc acg  atc gac       11041
Arg Asn Asp  Ile Leu Ala Gly Ile  Phe Glu Pro Ala Thr  Ile Asp            
        1725                 1730                 1735                    

att gat ctg  gct atc ttg ctg aca  aaa gca aga gaa cat  agc gtt       11086
Ile Asp Leu  Ala Ile Leu Leu Thr  Lys Ala Arg Glu His  Ser Val            
        1740                 1745                 1750                    

gcc ttg gta  ggt cca gcg gcg gag  gaa ctc ttt gat ccg  gtt cct       11131
Ala Leu Val  Gly Pro Ala Ala Glu  Glu Leu Phe Asp Pro  Val Pro            
        1755                 1760                 1765                    

gaa cag gat  cta ttt gag gcg cta  aat gaa acc tta acg  cta tgg       11176
Glu Gln Asp  Leu Phe Glu Ala Leu  Asn Glu Thr Leu Thr  Leu Trp            
        1770                 1775                 1780                    

aac tcg ccg  ccc gac tgg gct ggc  gat gag cga aat gta  gtg ctt       11221
Asn Ser Pro  Pro Asp Trp Ala Gly  Asp Glu Arg Asn Val  Val Leu            
        1785                 1790                 1795                    

acg ttg tcc  cgc att tgg tac agc  gca gta acc ggc aaa  atc gcg       11266
Thr Leu Ser  Arg Ile Trp Tyr Ser  Ala Val Thr Gly Lys  Ile Ala            
        1800                 1805                 1810                    

ccg aag gat  gtc gct gcc gac tgg  gca atg gag cgc ctg  ccg gcc       11311
Pro Lys Asp  Val Ala Ala Asp Trp  Ala Met Glu Arg Leu  Pro Ala            
        1815                 1820                 1825                    

cag tat cag  ccc gtc ata ctt gaa  gct aga cag gct tat  ctt gga       11356
Gln Tyr Gln  Pro Val Ile Leu Glu  Ala Arg Gln Ala Tyr  Leu Gly            
        1830                 1835                 1840                    

caa gaa gaa  gat cgc ttg gcc tcg  cgc gca gat cag ttg  gaa gaa       11401
Gln Glu Glu  Asp Arg Leu Ala Ser  Arg Ala Asp Gln Leu  Glu Glu            
        1845                 1850                 1855                    

ttt gtc cac  tac gtg aaa ggc gag  atc acc aag gta gtc  ggc aaa       11446
Phe Val His  Tyr Val Lys Gly Glu  Ile Thr Lys Val Val  Gly Lys            
        1860                 1865                 1870                    

taa tgtctagcta gaaattcgtt caagccgacg ccgcttcgcc ggcgttaact           11499

caagcgatta gatgcactaa gcacataatt gctcacagcc aaactatcag gtcaagtctg    11559

cttttattat ttttaagcgt gcataataag ccctacacaa attgggagat atatcatgca    11619

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga    11679

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa    11739

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga    11799

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt    11859

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt    11919

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat    11979

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct    12039

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca    12099

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag    12159

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc    12219

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga    12279

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca    12339

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag    12399

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg    12459

aagagcgcct gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat    12519

ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagtat acactccgct    12579

atcgctacgt gactgggtca tggctgcgcc ccgacacccg ccaacacccg ctgacgcgcc    12639

ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag    12699

ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgaggcagg gtgccttgat    12759

gtgggcgccg gcggtcgagt ggcgacggcg cggcttgtcc gcgccctggt agattgcctg    12819

gccgtaggcc agccattttt gagcggccag cggccgcgat aggccgacgc gaagcggcgg    12879

ggcgtaggga gcgcagcgac cgaagggtag gcgctttttg cagctcttcg gctgtgcgct    12939

ggccagacag ttatgcacag gccaggcggg ttttaagagt tttaataagt tttaaagagt    12999

tttaggcgga aaaatcgcct tttttctctt ttatatcagt cacttacatg tgtgaccggt    13059

tcccaatgta cggctttggg ttcccaatgt acgggttccg gttcccaatg tacggctttg    13119

ggttcccaat gtacgtgcta tccacaggaa agagaccttt tcgacctttt tcccctgcta    13179

gggcaatttg ccctagcatc tgctccgtac attaggaacc ggcggatgct tcgccctcga    13239

tcaggttgcg gtagcgcatg actaggatcg ggccagcctg ccccgcctcc tccttcaaat    13299

cgtactccgg caggtcattt gacccgatca gcttgcgcac ggtgaaacag aacttcttga    13359

actctccggc gctgccactg cgttcgtaga tcgtcttgaa caaccatctg gcttctgcct    13419

tgcctgcggc gcggcgtgcc aggcggtaga gaaaacggcc gatgccggga tcgatcaaaa    13479

agtaatcggg gtgaaccgtc agcacgtccg ggttcttgcc ttctgtgatc tcgcggtaca    13539

tccaatcagc tagctcgatc tcgatgtact ccggccgccc ggtttcgctc tttacgatct    13599

tgtagcggct aatcaaggct tcaccctcgg ataccgtcac caggcggccg ttcttggcct    13659

tcttcgtacg ctgcatggca acgtgcgtgg tgtttaaccg aatgcaggtt tctaccaggt    13719

cgtctttctg ctttccgcca tcggctcgcc ggcagaactt gagtacgtcc gcaacgtgtg    13779

gacggaacac gcggccgggc ttgtctccct tcccttcccg gtatcggttc atggattcgg    13839

ttagatggga aaccgccatc agtaccaggt cgtaatccca cacactggcc atgccggccg    13899

gccctgcgga aacctctacg tgcccgtctg gaagctcgta gcggatcacc tcgccagctc    13959

gtcggtcacg cttcgacaga cggaaaacgg ccacgtccat gatgctgcga ctatcgcggg    14019

tgcccacgtc atagagcatc ggaacgaaaa aatctggttg ctcgtcgccc ttgggcggct    14079

tcctaatcga cggcgcaccg gctgccggcg gttgccggga ttctttgcgg attcgatcag    14139

cggccgcttg ccacgattca ccggggcgtg cttctgcctc gatgcgttgc cgctgggcgg    14199

cctgcgcggc cttcaacttc tccaccaggt catcacccag cgccgcgccg atttgtaccg    14259

ggccggatgg tttgcgaccg tcacgccgat tcctcgggct tgggggttcc agtgccattg    14319

cagggccggc agacaaccca gccgcttacg cctggccaac cgcccgttcc tccacacatg    14379

gggcattcca cggcgtcggt gcctggttgt tcttgatttt ccatgccgcc tcctttagcc    14439

gctaaaattc atctactcat ttattcattt gctcatttac tctggtagct gcgcgatgta    14499

ttcagatagc agctcggtaa tggtcttgcc ttggcgtacc gcgtacatct tcagcttggt    14559

gtgatcctcc gccggcaact gaaagttgac ccgcttcatg gctggcgtgt ctgccaggct    14619

ggccaacgtt gcagccttgc tgctgcgtgc gctcggacgg ccggcactta gcgtgtttgt    14679

gcttttgctc attttctctt tacctcatta actcaaatga gttttgattt aatttcagcg    14739

gccagcgcct ggacctcgcg ggcagcgtcg ccctcgggtt ctgattcaag aacggttgtg    14799

ccggcggcgg cagtgcctgg gtagctcacg cgctgcgtga tacgggactc aagaatgggc    14859

agctcgtacc cggccagcgc ctcggcaacc tcaccgccga tgcgcgtgcc tttgatcgcc    14919

cgcgacacga caaaggccgc ttgtagcctt ccatccgtga cctcaatgcg ctgcttaacc    14979

agctccacca ggtcggcggt ggcccatatg tcgtaagggc ttggctgcac cggaatcagc    15039

acgaagtcgg ctgccttgat cgcggacaca gccaagtccg ccgcctgggg cgctccgtcg    15099

atcactacga agtcgcgccg gccgatggcc ttcacgtcgc ggtcaatcgt cgggcggtcg    15159

atgccgacaa cggttagcgg ttgatcttcc cgcacggccg cccaatcgcg ggcactgccc    15219

tggggatcgg aatcgactaa cagaacatcg gccccggcga gttgcagggc gcgggctaga    15279

tgggttgcga tggtcgtctt gcctgacccg cctttctggt taagtacagc gataaccttc    15339

atgcgttccc cttgcgtatt tgtttattta ctcatcgcat catatacgca gcgaccgcat    15399

gacgcaagct gttttactca aatacacatc acctttttag acggcggcgc tcggtttctt    15459

cagcggccaa gctggccggc caggccgcca gcttggcatc agacaaaccg gccaggattt    15519

catgcagccg cacggttgag acgtgcgcgg gcggctcgaa cacgtacccg gccgcgatca    15579

tctccgcctc gatctcttcg gtaatgaaaa acggttcgtc ctggccgtcc tggtgcggtt    15639

tcatgcttgt tcctcttggc gttcattctc ggcggccgcc agggcgtcgg cctcggtcaa    15699

tgcgtcctca cggaaggcac cgcgccgcct ggcctcggtg ggcgtcactt cctcgctgcg    15759

ctcaagtgcg cggtacaggg tcgagcgatg cacgccaagc agtgcagccg cctctttcac    15819

ggtgcggcct tcctggtcga tcagctcgcg ggcgtgcgcg atctgtgccg gggtgagggt    15879

agggcggggg ccaaacttca cgcctcgggc cttggcggcc tcgcgcccgc tccgggtgcg    15939

gtcgatgatt agggaacgct cgaactcggc aatgccggcg aacacggtca acaccatgcg    15999

gccggccggc gtggtggtgt cggcccacgg ctctgccagg ctacgcaggc ccgcgccggc    16059

ctcctggatg cgctcggcaa tgtccagtag gtcgcgggtg ctgcgggcca ggcggtctag    16119

cctggtcact gtcacaacgt cgccagggcg taggtggtca agcatcctgg ccagctccgg    16179

gcggtcgcgc ctggtgccgg tgatcttctc ggaaaacagc ttggtgcagc cggccgcgtg    16239

cagttcggcc cgttggttgg tcaagtcctg gtcgtcggtg ctgacgcggg catagcccag    16299

caggccagcg gcggcgctct tgttcatggc gtaatgtctc cggttctagt cgcaagtatt    16359

ctactttatg cgactaaaac acgcgacaag aaaacgccag gaaaagggca gggcggcagc    16419

ctgtcgcgta acttaggact tgtgcgacat gtcgttttca gaagacggct gcactgaacg    16479

tcagaagccg actgcactat agcagcggag gggttggatc aaagtacttt aaagtacttt    16539

aaagtacttt aaagtacttt gatcccgagg ggaaccctgt ggttggcatg cacatacaaa    16599

tggacgaacg gataaacctt ttcacgccct tttaaatatc cgattattct aataaacgct    16659

cttttctctt ag                                                        16671


<210>  18
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His 
1               5                   10                  15      


Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly 
            20                  25                  30          


Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr 
        35                  40                  45              


Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe 
    50                  55                  60                  


Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp 
65                  70                  75                  80  


Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met 
                85                  90                  95      


Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu 
            100                 105                 110         


Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe 
        115                 120                 125             


Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala 
    130                 135                 140                 


Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile 
145                 150                 155                 160 


Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val 
                165                 170                 175     


Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr 
            180                 185                 190         


Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr 
        195                 200                 205             


Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly 
    210                 215                 220                 


Met Asp Glu Leu Tyr Lys 
225                 230 


<210>  19
<211>  1379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210>  20
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Gly Glu Ala Val Ile Ala Glu Val Ser Thr Gln Leu Ser Glu Val 
1               5                   10                  15      


Val Gly Val Ile Glu Arg His Leu Glu Pro Thr Leu Leu Ala Val His 
            20                  25                  30          


Leu Tyr Gly Ser Ala Val Asp Gly Gly Leu Lys Pro His Ser Asp Ile 
        35                  40                  45              


Asp Leu Leu Val Thr Val Thr Val Arg Leu Asp Glu Thr Thr Arg Arg 
    50                  55                  60                  


Ala Leu Ile Asn Asp Leu Leu Glu Thr Ser Ala Ser Pro Gly Glu Ser 
65                  70                  75                  80  


Glu Ile Leu Arg Ala Val Glu Val Thr Ile Val Val His Asp Asp Ile 
                85                  90                  95      


Ile Pro Trp Arg Tyr Pro Ala Lys Arg Glu Leu Gln Phe Gly Glu Trp 
            100                 105                 110         


Gln Arg Asn Asp Ile Leu Ala Gly Ile Phe Glu Pro Ala Thr Ile Asp 
        115                 120                 125             


Ile Asp Leu Ala Ile Leu Leu Thr Lys Ala Arg Glu His Ser Val Ala 
    130                 135                 140                 


Leu Val Gly Pro Ala Ala Glu Glu Leu Phe Asp Pro Val Pro Glu Gln 
145                 150                 155                 160 


Asp Leu Phe Glu Ala Leu Asn Glu Thr Leu Thr Leu Trp Asn Ser Pro 
                165                 170                 175     


Pro Asp Trp Ala Gly Asp Glu Arg Asn Val Val Leu Thr Leu Ser Arg 
            180                 185                 190         


Ile Trp Tyr Ser Ala Val Thr Gly Lys Ile Ala Pro Lys Asp Val Ala 
        195                 200                 205             


Ala Asp Trp Ala Met Glu Arg Leu Pro Ala Gln Tyr Gln Pro Val Ile 
    210                 215                 220                 


Leu Glu Ala Arg Gln Ala Tyr Leu Gly Gln Glu Glu Asp Arg Leu Ala 
225                 230                 235                 240 


Ser Arg Ala Asp Gln Leu Glu Glu Phe Val His Tyr Val Lys Gly Glu 
                245                 250                 255     


Ile Thr Lys Val Val Gly Lys 
            260             


<210>  21
<211>  211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ribozyme-Guide-Ribozyme (RGR) construct

<400>  21
agctccctga tgagtccgtg aggacgaaac gagtaagctc gtcggagctc cttgtcccat       60

caagttttag agctagaaat agcaagttaa aataaggcta gtccgttatc aacttgaaaa      120

agtggcaccg agtcggtgct tttggccggc atggtcccag cctcctcgct ggcgccggct      180

gggcaacatg cttcggcatg gcgaatggga c                                     211


<210>  22
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  generic RGR construct


<220>
<221>  misc_feature
<222>  (44)..(60)
<223>  N is any sequence corresponding to a gRNA sequence for any gene

<400>  22
agctccctga tgagtccgtg aggacgaaac gagtaagctc gtcnnnnnnn nnnnnnnnnn       60

ggccggcatg gtcccagcct cctcgctggc gccggctggg caacatgctt cggcatggcg      120

aatgggac                                                               128


