                         SEQUENCE LISTING

<110>  Danisco US Inc.
 
<120>  TRYPSIN-LIKE SERINE PROTEASES AND USES THEREOF

<130>  NB41242

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  1395
<212>  DNA
<213>  Streptomyces sp. C009

<400>  1
atgttccacc gacacgccag agccgcgtgc gtgggcgccg tgaccgtggg cgcgctggtc       60
ctgacggcac tgcaaggggc cgctgcggcg ccctcggacg gccacggccc ggtcgccgcg      120
cccccaccgg cggcccgttc ggcggccgac gccctcgccg tgtccgccgt acagccggac      180
gtgctgcgtg ccatgcaacg ggacctcggc ctcactccgg ccgaggcccg gcagcggctg      240
gcgaacgagg cggaggcggg cgcgaccgcc gcccgtctcc ggcagcggct ggccggctcg      300
tacgccggtg cctgggtcga ggggcacgcg tcgtccgtcc tgaccgtcgc caccacccgg      360
gccgatgacg cggcggcgat cagggcgagc ggcgccgagg ccgatgtcgt cgcgcacagt      420
ctggcggcgc tcgaccgcac caaggcggct ctggaccgtg cggcccgcac cgccgccgac      480
gtcggcgtcc ccgtctggta cgtcgacgtc cgcaccaact ccgtggtggt ccaggccgtg      540
gacccggggg cggcggcgtc gctggtcggc cgggtgagcg aggccgaccg gtcgcggata      600
cgggtcgtcc cgacgcggga acggccgcgc ccgctgtacg acatcagggg cggtgacgcg      660
tactacatgg gcggctccgg ccgctgctcg gtgggcttct cggtcacccg tgggacgcag      720
gcgggcttcg cgacggcggg gcactgcggc cgggccggca cgaccacgac cgggtacaac      780
cgggtggcgc agggctcgtt ccaggcctcg acgttcccgg gccgggacac ggcctgggtg      840
gcgacgaaca ccaactggac cgcgaccccg tacgtgaagg gcgcgggcgg cgcgaacgtc      900
cgggtggccg gttcggtcca gcagccggtc ggcgcctcgg tctgccgctc gggctccacc      960
acgggctggc actgcggcac catccagcag cacaacacca gcgtgacgta cccggagggc     1020
accatcaccg gggtgacgcg gacctcggtg tgcgccgaac ccggtgactc cggtgggtcg     1080
tacatctccg gcagccaggc gcagggcgtc acctccggcg gttcgggcga ctgccggagc     1140
gggggtacga cctaccacca gccgatcaac ccgctgctgc aggcgtacgg gctgacgctg     1200
acgacgacca ccggacccgg cgacccgggc ccgggcgacc cggacgagcc gggcggcaca     1260
tgggcggccg gcaccgtcta ccgggcgggt gaccaggtca cgtacggcgg tgcgacctac     1320
cgctgcctgc agggccacca ggcgcaggcc gggtgggaac cgccgaacgt cccggcgctc     1380
tggcagcgcg gctga                                                      1395

<210>  2
<211>  29
<212>  PRT
<213>  Streptomyces sp. C009

<400>  2
Met Phe His Arg His Ala Arg Ala Ala Cys Val Gly Ala Val Thr Val 
1               5                   10                  15      
Gly Ala Leu Val Leu Thr Ala Leu Gln Gly Ala Ala Ala 
            20                  25                  

<210>  3
<211>  464
<212>  PRT
<213>  Streptomyces sp. C009

<400>  3
Met Phe His Arg His Ala Arg Ala Ala Cys Val Gly Ala Val Thr Val 
1               5                   10                  15      
Gly Ala Leu Val Leu Thr Ala Leu Gln Gly Ala Ala Ala Ala Pro Ser 
            20                  25                  30          
Asp Gly His Gly Pro Val Ala Ala Pro Pro Pro Ala Ala Arg Ser Ala 
        35                  40                  45              
Ala Asp Ala Leu Ala Val Ser Ala Val Gln Pro Asp Val Leu Arg Ala 
    50                  55                  60                  
Met Gln Arg Asp Leu Gly Leu Thr Pro Ala Glu Ala Arg Gln Arg Leu 
65                  70                  75                  80  
Ala Asn Glu Ala Glu Ala Gly Ala Thr Ala Ala Arg Leu Arg Gln Arg 
                85                  90                  95      
Leu Ala Gly Ser Tyr Ala Gly Ala Trp Val Glu Gly His Ala Ser Ser 
            100                 105                 110         
Val Leu Thr Val Ala Thr Thr Arg Ala Asp Asp Ala Ala Ala Ile Arg 
        115                 120                 125             
Ala Ser Gly Ala Glu Ala Asp Val Val Ala His Ser Leu Ala Ala Leu 
    130                 135                 140                 
Asp Arg Thr Lys Ala Ala Leu Asp Arg Ala Ala Arg Thr Ala Ala Asp 
145                 150                 155                 160 
Val Gly Val Pro Val Trp Tyr Val Asp Val Arg Thr Asn Ser Val Val 
                165                 170                 175     
Val Gln Ala Val Asp Pro Gly Ala Ala Ala Ser Leu Val Gly Arg Val 
            180                 185                 190         
Ser Glu Ala Asp Arg Ser Arg Ile Arg Val Val Pro Thr Arg Glu Arg 
        195                 200                 205             
Pro Arg Pro Leu Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly 
    210                 215                 220                 
Gly Ser Gly Arg Cys Ser Val Gly Phe Ser Val Thr Arg Gly Thr Gln 
225                 230                 235                 240 
Ala Gly Phe Ala Thr Ala Gly His Cys Gly Arg Ala Gly Thr Thr Thr 
                245                 250                 255     
Thr Gly Tyr Asn Arg Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe 
            260                 265                 270         
Pro Gly Arg Asp Thr Ala Trp Val Ala Thr Asn Thr Asn Trp Thr Ala 
        275                 280                 285             
Thr Pro Tyr Val Lys Gly Ala Gly Gly Ala Asn Val Arg Val Ala Gly 
    290                 295                 300                 
Ser Val Gln Gln Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr 
305                 310                 315                 320 
Thr Gly Trp His Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr 
                325                 330                 335     
Tyr Pro Glu Gly Thr Ile Thr Gly Val Thr Arg Thr Ser Val Cys Ala 
            340                 345                 350         
Glu Pro Gly Asp Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln 
        355                 360                 365             
Gly Val Thr Ser Gly Gly Ser Gly Asp Cys Arg Ser Gly Gly Thr Thr 
    370                 375                 380                 
Tyr His Gln Pro Ile Asn Pro Leu Leu Gln Ala Tyr Gly Leu Thr Leu 
385                 390                 395                 400 
Thr Thr Thr Thr Gly Pro Gly Asp Pro Gly Pro Gly Asp Pro Asp Glu 
                405                 410                 415     
Pro Gly Gly Thr Trp Ala Ala Gly Thr Val Tyr Arg Ala Gly Asp Gln 
            420                 425                 430         
Val Thr Tyr Gly Gly Ala Thr Tyr Arg Cys Leu Gln Gly His Gln Ala 
        435                 440                 445             
Gln Ala Gly Trp Glu Pro Pro Asn Val Pro Ala Leu Trp Gln Arg Gly 
    450                 455                 460                 

<210>  4
<211>  1371
<212>  DNA
<213>  Streptomyces sp. C001

<400>  4
atgctccgac gacacgcccg tgcggcgtgt accgcgctgg ccgccgccgg gatggtgctg       60
gccgggcttc aggccgggtc cgccaccgcc gcgcagccct cccccggagc cgcgcccggc      120
gcgcagagcg ccgctcgggc gctcggcgcc gccgaggcgc agcccgaact gctcgccgcg      180
atgggccgcg acctgggcct gacccgggcc caggcagagc gccggctcgt caacgaggcc      240
gaggcgggcg ccgcggccgc ccggctccgc gaccggatcg gcggctcctt cgccggggcc      300
tgggtcgagg gggccgagtc cggctccctg accgtggcca ccacccgcgc cgccgacctc      360
gacgcgatcc gggcggccgg ggcgacggcc cggctcgtcc ggcacgacct gtcctcgctg      420
gagcgggcga aggccgccct cgaccgggcc gcgggcgccg acgcgccggt gcggtacgtg      480
gacgtgcgcg ccaaccagtt ggtcgtcgag gaggtccggg ccggtgccgg ggcgcgcctg      540
gcggcggcca ccggggtgcc gcgggagctg gtgcgggtgg agcggagcac cgaggcgccg      600
cgcccgctgt acgacctccg gggcggcgac gcgtactaca tgggcggcgg cgggcgctgc      660
tcggtcggct tcccggtgac ccggggcacc acgcagggct tcgcgacggc cgggcactgc      720
ggccgcgccg gccagaccac cagcggctac aaccaggtcg cccagggcag cttccagggc      780
tcggtcttcc ccggcagcga catggcgtgg gtcgcggcca acagcagctg gaccgccacc      840
ccgtacgtga agggcgcggg cggcgcgaac gtccaggtca ccggctccgt gctgcagccc      900
gtgggcgcct ccgtctgccg ctcgggctcc accaccggct ggcactgcgg caccatccag      960
cagcacaaca cgagcgtgac gtacccggag ggcacgatct ccggcgtgac ccggacgacg     1020
gtctgcgccg agcccggcga ctcgggcggc tcgtacatct ccggcagcca ggcgcagggc     1080
gtcacctcgg gcggctccgg caactgctcc agcggcggca ccacgtactt ccagccgctg     1140
aacccgatcc tgtcggccta cggcctgacc ctgaagacca ccggcaccga cccgggcccc     1200
ggcccgggcc cgggcgagcc ggagccgggc ggcacgtgga aggcgggcac ggtgtacgcg     1260
gccggcgcca ccgtcacgta cggcggttcc acctaccgct gcctccaggg ccaccaggcg     1320
cagaccggct gggagccgcc gaacgtaccg gcgctctggc agcgggtctg a              1371

<210>  5
<211>  30
<212>  PRT
<213>  Streptomyces sp. C001

<400>  5
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ala Leu Ala Ala Ala 
1               5                   10                  15      
Gly Met Val Leu Ala Gly Leu Gln Ala Gly Ser Ala Thr Ala 
            20                  25                  30  

<210>  6
<211>  456
<212>  PRT
<213>  Streptomyces sp. C001

<400>  6
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ala Leu Ala Ala Ala 
1               5                   10                  15      
Gly Met Val Leu Ala Gly Leu Gln Ala Gly Ser Ala Thr Ala Ala Gln 
            20                  25                  30          
Pro Ser Pro Gly Ala Ala Pro Gly Ala Gln Ser Ala Ala Arg Ala Leu 
        35                  40                  45              
Gly Ala Ala Glu Ala Gln Pro Glu Leu Leu Ala Ala Met Gly Arg Asp 
    50                  55                  60                  
Leu Gly Leu Thr Arg Ala Gln Ala Glu Arg Arg Leu Val Asn Glu Ala 
65                  70                  75                  80  
Glu Ala Gly Ala Ala Ala Ala Arg Leu Arg Asp Arg Ile Gly Gly Ser 
                85                  90                  95      
Phe Ala Gly Ala Trp Val Glu Gly Ala Glu Ser Gly Ser Leu Thr Val 
            100                 105                 110         
Ala Thr Thr Arg Ala Ala Asp Leu Asp Ala Ile Arg Ala Ala Gly Ala 
        115                 120                 125             
Thr Ala Arg Leu Val Arg His Asp Leu Ser Ser Leu Glu Arg Ala Lys 
    130                 135                 140                 
Ala Ala Leu Asp Arg Ala Ala Gly Ala Asp Ala Pro Val Arg Tyr Val 
145                 150                 155                 160 
Asp Val Arg Ala Asn Gln Leu Val Val Glu Glu Val Arg Ala Gly Ala 
                165                 170                 175     
Gly Ala Arg Leu Ala Ala Ala Thr Gly Val Pro Arg Glu Leu Val Arg 
            180                 185                 190         
Val Glu Arg Ser Thr Glu Ala Pro Arg Pro Leu Tyr Asp Leu Arg Gly 
        195                 200                 205             
Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe 
    210                 215                 220                 
Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys 
225                 230                 235                 240 
Gly Arg Ala Gly Gln Thr Thr Ser Gly Tyr Asn Gln Val Ala Gln Gly 
                245                 250                 255     
Ser Phe Gln Gly Ser Val Phe Pro Gly Ser Asp Met Ala Trp Val Ala 
            260                 265                 270         
Ala Asn Ser Ser Trp Thr Ala Thr Pro Tyr Val Lys Gly Ala Gly Gly 
        275                 280                 285             
Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ala Ser 
    290                 295                 300                 
Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln 
305                 310                 315                 320 
Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val 
                325                 330                 335     
Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr 
            340                 345                 350         
Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn 
        355                 360                 365             
Cys Ser Ser Gly Gly Thr Thr Tyr Phe Gln Pro Leu Asn Pro Ile Leu 
    370                 375                 380                 
Ser Ala Tyr Gly Leu Thr Leu Lys Thr Thr Gly Thr Asp Pro Gly Pro 
385                 390                 395                 400 
Gly Pro Gly Pro Gly Glu Pro Glu Pro Gly Gly Thr Trp Lys Ala Gly 
                405                 410                 415     
Thr Val Tyr Ala Ala Gly Ala Thr Val Thr Tyr Gly Gly Ser Thr Tyr 
            420                 425                 430         
Arg Cys Leu Gln Gly His Gln Ala Gln Thr Gly Trp Glu Pro Pro Asn 
        435                 440                 445             
Val Pro Ala Leu Trp Gln Arg Val 
    450                 455     

<210>  7
<211>  1356
<212>  DNA
<213>  Streptomyces sp. C003

<400>  7
atgctccgac gacacgcccg cgcggcgtgt accgcgctgg tcgccgccgg gatggcgctg       60
gccggcctcc aggccggcac cgccaccgcg gcaccggacg ggaaaccggc agcgaagacc      120
gccgctcgga ccctcgccgc caccgccgcc cagcccgaac tcctctccgc catgcagcgc      180
gacctgggac tcacccgccc ccaggcactg acccggctcg ccaacgaggc cgaggccggc      240
gccaccgccg cccggctccg ccagggcctc ggcggcgcct tcgccggagc ctgggtcgac      300
gggcccgagt ccggcaccct gaccgtggcc accacccgcg ccgccgacgc ggccgcgata      360
cgcgccaccg gcgccgacgc ccggctcgtc tcccacagcc tgaccgccct ggagcgggcc      420
aagcggaccc tggacggggc cgccaccgcc gaggcacccg tccgctacgt cgacgtccgc      480
gccaacgtcc tcgtcgtcga ggagacgcgg gccggcgccg gggcacggct cgtccgggcg      540
accggggtcc cgcgcgacct ggtgcgcgtg gtcaggacca catccgcacc gcgcccgctg      600
tacgacatcc ggggcggcga cgcgtactac atgggcggcg gcggccgctg ctccgtcggt      660
ttcgcggtga cccgcggcac gacgcagggc ttcgccactg cgggccactg cggccgcgcc      720
ggcacgacga ccagcggctt caaccaggtc gcccagggca gcttccaggg ctcgatcttc      780
cccggcaacg acatggcctg ggtcgccgcc aacaccaact ggacctccac cccgtacgtc      840
aagggctccg gcggcgcgaa cgtccaggtg accgggtccg tcctccagcc cgtcggcgcg      900
tccgtctgcc gctcaggctc gaccaccggc tggcactgcg gcacgatcca gcagcacaac      960
accagcgtca cctaccccga gggcaccatc tccggagtga cccgcacgac ggtctgcgcc     1020
gaacccggcg actccggcgg ctcgtacatc tccggcagcc aggcccaggg cgtgacctcg     1080
ggcggctcgg gcaactgctc cagcggcggc acgaccttct tccagccgct caacccgctg     1140
ctgcagaact acggcctgac cctgaagacc accggcagcg atccgggccc cgggcccggc     1200
gagccgcagc ccggcggcac ctgggcggcg ggcaaggtct acgcggccgg tgacacggtc     1260
acctacggcg gcgcgaccta ccgctgcctc cagggccacc aggcccagac cggctgggag     1320
ccgccgaacg tcccggccct ctggcagcgc cagtga                               1356

<210>  8
<211>  30
<212>  PRT
<213>  Streptomyces sp. C003

<400>  8
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ala Leu Val Ala Ala 
1               5                   10                  15      
Gly Met Ala Leu Ala Gly Leu Gln Ala Gly Thr Ala Thr Ala 
            20                  25                  30  

<210>  9
<211>  451
<212>  PRT
<213>  Streptomyces sp. C003

<400>  9
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ala Leu Val Ala Ala 
1               5                   10                  15      
Gly Met Ala Leu Ala Gly Leu Gln Ala Gly Thr Ala Thr Ala Ala Pro 
            20                  25                  30          
Asp Gly Lys Pro Ala Ala Lys Thr Ala Ala Arg Thr Leu Ala Ala Thr 
        35                  40                  45              
Ala Ala Gln Pro Glu Leu Leu Ser Ala Met Gln Arg Asp Leu Gly Leu 
    50                  55                  60                  
Thr Arg Pro Gln Ala Leu Thr Arg Leu Ala Asn Glu Ala Glu Ala Gly 
65                  70                  75                  80  
Ala Thr Ala Ala Arg Leu Arg Gln Gly Leu Gly Gly Ala Phe Ala Gly 
                85                  90                  95      
Ala Trp Val Asp Gly Pro Glu Ser Gly Thr Leu Thr Val Ala Thr Thr 
            100                 105                 110         
Arg Ala Ala Asp Ala Ala Ala Ile Arg Ala Thr Gly Ala Asp Ala Arg 
        115                 120                 125             
Leu Val Ser His Ser Leu Thr Ala Leu Glu Arg Ala Lys Arg Thr Leu 
    130                 135                 140                 
Asp Gly Ala Ala Thr Ala Glu Ala Pro Val Arg Tyr Val Asp Val Arg 
145                 150                 155                 160 
Ala Asn Val Leu Val Val Glu Glu Thr Arg Ala Gly Ala Gly Ala Arg 
                165                 170                 175     
Leu Val Arg Ala Thr Gly Val Pro Arg Asp Leu Val Arg Val Val Arg 
            180                 185                 190         
Thr Thr Ser Ala Pro Arg Pro Leu Tyr Asp Ile Arg Gly Gly Asp Ala 
        195                 200                 205             
Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe Ala Val Thr 
    210                 215                 220                 
Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys Gly Arg Ala 
225                 230                 235                 240 
Gly Thr Thr Thr Ser Gly Phe Asn Gln Val Ala Gln Gly Ser Phe Gln 
                245                 250                 255     
Gly Ser Ile Phe Pro Gly Asn Asp Met Ala Trp Val Ala Ala Asn Thr 
            260                 265                 270         
Asn Trp Thr Ser Thr Pro Tyr Val Lys Gly Ser Gly Gly Ala Asn Val 
        275                 280                 285             
Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ala Ser Val Cys Arg 
    290                 295                 300                 
Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln Gln His Asn 
305                 310                 315                 320 
Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val Thr Arg Thr 
                325                 330                 335     
Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr Ile Ser Gly 
            340                 345                 350         
Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn Cys Ser Ser 
        355                 360                 365             
Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro Leu Leu Gln Asn Tyr 
    370                 375                 380                 
Gly Leu Thr Leu Lys Thr Thr Gly Ser Asp Pro Gly Pro Gly Pro Gly 
385                 390                 395                 400 
Glu Pro Gln Pro Gly Gly Thr Trp Ala Ala Gly Lys Val Tyr Ala Ala 
                405                 410                 415     
Gly Asp Thr Val Thr Tyr Gly Gly Ala Thr Tyr Arg Cys Leu Gln Gly 
            420                 425                 430         
His Gln Ala Gln Thr Gly Trp Glu Pro Pro Asn Val Pro Ala Leu Trp 
        435                 440                 445             
Gln Arg Gln 
    450     

<210>  10
<211>  1365
<212>  DNA
<213>  Streptomyces sp. S055

<400>  10
atgctccaca gacatgccaa agcgtcctgt gccgcgttcg cggccgtcgg cgcgctggtg       60
ctggcagggc tgcccgcaac ggccgccgcg gacgcggccc cacccgcacc gcccaccgcg      120
gccgcgacgg cgggcgtcga caacgcctcg ccagggctgc tgcgggccat gcagcgcgac      180
ctcggagtga ccgaggcgca ggcaagggcg cggctggcga atgaggccga ggccggtgcg      240
gtcgccggac ggctgcggat atcgctcggc ggcgacttcg ccggtgcctg ggtgcacggc      300
cccgactccg ccaaactgag cgtggccacc acggacgcct cggacagggc cgcgatcgag      360
gccgggggcg cgcacgccgt cgtcgtacgg cacaccctgc cccggctgga cggagcgctg      420
gcgaagctgg acgaggcggc gtccgccgct ccgtccacgg ccgccgaggt acccgtccgg      480
tacgtggacg tcacggcgaa ccgcgtgacg ctgcaaaccg tacggccggc cgccgcgaag      540
gcgctcgtcg tggccgcggg ggtcgacccc gcgctcgtcc gcgtggagaa gtcggcggag      600
cgtccgcgtc cgctgtacga cctgcggggc ggcgacgcgt actacatgaa cggcagcggc      660
cgctgttccg tcggatttcc ggtcaccaag ggaacgcagc agggcttcgc caccgccgga      720
cactgcgggc gcgtcggcac gacgaccacc ggctacaacc aggtcgccca ggggtccttc      780
caggcctcca ccttccccgg ccgtgacatg gcctgggtgg ccaccaacag caactggacc      840
gccaccccct acgtcaaggg caacagcgga aacgtccagg tcgccggctc gacacaggcc      900
gccgtcggcg cgtcggtctg ccgttcgggg tccaccaccg gctggcactg cggcaccatc      960
cagcagcaca acaccagcgt cacctacccc gaaggcacca tcagtggtgt gacccgcacc     1020
acggtctgtg ccgagcccgg cgactcaggc ggctcctaca tctccggcag ccaggcccag     1080
ggcgtcacct ccggcgggtc gggcaactgc cgctccggcg gcaccaccta ctaccagccg     1140
atcaacccgc tgctccagaa ctacgggctg accctcaaga ccacctcgga cgaccccggc     1200
ccgggtgagc cgggggagcc cggcggcacc tgggccgcgg gaaccgtcta cgcggcggga     1260
gcccaggtga cgtacggcgg ggccacctac cggtgcctcc agggacacca ggcccaggcc     1320
ggctgggagc ccccgaacgt gcccgccctg tggcagcggg cgtga                     1365

<210>  11
<211>  28
<212>  PRT
<213>  Streptomyces sp. S055

<400>  11
Met Leu His Arg His Ala Lys Ala Ser Cys Ala Ala Phe Ala Ala Val 
1               5                   10                  15      
Gly Ala Leu Val Leu Ala Gly Leu Pro Ala Thr Ala 
            20                  25              

<210>  12
<211>  454
<212>  PRT
<213>  Streptomyces sp. S055

<400>  12
Met Leu His Arg His Ala Lys Ala Ser Cys Ala Ala Phe Ala Ala Val 
1               5                   10                  15      
Gly Ala Leu Val Leu Ala Gly Leu Pro Ala Thr Ala Ala Ala Asp Ala 
            20                  25                  30          
Ala Pro Pro Ala Pro Pro Thr Ala Ala Ala Thr Ala Gly Val Asp Asn 
        35                  40                  45              
Ala Ser Pro Gly Leu Leu Arg Ala Met Gln Arg Asp Leu Gly Val Thr 
    50                  55                  60                  
Glu Ala Gln Ala Arg Ala Arg Leu Ala Asn Glu Ala Glu Ala Gly Ala 
65                  70                  75                  80  
Val Ala Gly Arg Leu Arg Ile Ser Leu Gly Gly Asp Phe Ala Gly Ala 
                85                  90                  95      
Trp Val His Gly Pro Asp Ser Ala Lys Leu Ser Val Ala Thr Thr Asp 
            100                 105                 110         
Ala Ser Asp Arg Ala Ala Ile Glu Ala Gly Gly Ala His Ala Val Val 
        115                 120                 125             
Val Arg His Thr Leu Pro Arg Leu Asp Gly Ala Leu Ala Lys Leu Asp 
    130                 135                 140                 
Glu Ala Ala Ser Ala Ala Pro Ser Thr Ala Ala Glu Val Pro Val Arg 
145                 150                 155                 160 
Tyr Val Asp Val Thr Ala Asn Arg Val Thr Leu Gln Thr Val Arg Pro 
                165                 170                 175     
Ala Ala Ala Lys Ala Leu Val Val Ala Ala Gly Val Asp Pro Ala Leu 
            180                 185                 190         
Val Arg Val Glu Lys Ser Ala Glu Arg Pro Arg Pro Leu Tyr Asp Leu 
        195                 200                 205             
Arg Gly Gly Asp Ala Tyr Tyr Met Asn Gly Ser Gly Arg Cys Ser Val 
    210                 215                 220                 
Gly Phe Pro Val Thr Lys Gly Thr Gln Gln Gly Phe Ala Thr Ala Gly 
225                 230                 235                 240 
His Cys Gly Arg Val Gly Thr Thr Thr Thr Gly Tyr Asn Gln Val Ala 
                245                 250                 255     
Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp Met Ala Trp 
            260                 265                 270         
Val Ala Thr Asn Ser Asn Trp Thr Ala Thr Pro Tyr Val Lys Gly Asn 
        275                 280                 285             
Ser Gly Asn Val Gln Val Ala Gly Ser Thr Gln Ala Ala Val Gly Ala 
    290                 295                 300                 
Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile 
305                 310                 315                 320 
Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly 
                325                 330                 335     
Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser 
            340                 345                 350         
Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly 
        355                 360                 365             
Asn Cys Arg Ser Gly Gly Thr Thr Tyr Tyr Gln Pro Ile Asn Pro Leu 
    370                 375                 380                 
Leu Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr Ser Asp Asp Pro Gly 
385                 390                 395                 400 
Pro Gly Glu Pro Gly Glu Pro Gly Gly Thr Trp Ala Ala Gly Thr Val 
                405                 410                 415     
Tyr Ala Ala Gly Ala Gln Val Thr Tyr Gly Gly Ala Thr Tyr Arg Cys 
            420                 425                 430         
Leu Gln Gly His Gln Ala Gln Ala Gly Trp Glu Pro Pro Asn Val Pro 
        435                 440                 445             
Ala Leu Trp Gln Arg Ala 
    450                 

<210>  13
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthesized gene

<400>  13
gtgagaagca aaaaattgtg gatcagcttg ttgtttgcgt taacgttaat ctttacgatg       60
gcgttcagca acatgagcgc gcaggctgct ggaaaagcac cggatggcaa accggcagca      120
aaaacagcag caagaacact ggcagcaaca gcagcgcaac cggaactgct gtcagcaatg      180
caaagagatc tgggcctgac aagaccgcaa gcacttacaa gactggcaaa tgaagcagaa      240
gcaggcgcaa cagcggcaag actgagacaa ggcctgggag gcgcatttgc aggcgcatgg      300
gttgatggac cggaatcagg cacactgaca gttgcaacaa caagagcagc agatgcagca      360
gcaattagag caacaggcgc agatgcaaga ctggtttcac attcactgac agcactggaa      420
agagcaaaaa gaacacttga tggcgcagcg acagcggaag caccggttag atatgttgat      480
gttagagcaa atgttctggt cgttgaagaa acaagagctg gcgcaggcgc tagactggtc      540
agagcgacag gcgttccgag agatcttgtt agagttgtta gaacaacatc agcaccgcgt      600
ccgctgtatg atattagagg cggagatgcg tattatatgg gaggcggagg cagatgctca      660
gttggctttg cagttacaag aggcacaaca caaggctttg cgacagcagg ccattgcggc      720
agagctggca caacaacatc tggctttaat caagttgcac aaggctcatt tcaaggctca      780
atttttccgg gaaatgatat ggcatgggtc gcagcaaata caaattggac atcaacaccg      840
tatgttaaag gctcaggcgg agcgaatgtt caagttacag gctcagttct gcagccggtt      900
ggcgcatcag tttgcagatc aggctcaaca acaggctggc attgcggaac aattcaacaa      960
cataatacaa gcgtcacata tccggaaggc acaatttcag gcgttacaag aacaacagtt     1020
tgcgcagaac ctggcgattc aggcggatca tatatttcag gcagccaagc acaaggcgtg     1080
acatcaggcg gaagcggcaa ttgctcatct ggcggaacaa cattttttca accgctgaat     1140
ccgctgctgc aaaattatgg cctgacactg aaaacaacag gatcagatcc gggaccggga     1200
cctggcgaac cgcaaccggg tggaacatgg gcagcaggca aagtttatgc agcaggcgat     1260
acagttacat atggcggagc tacatataga tgcctgcaag gccatcaagc acaaacagga     1320
tgggaaccgc ctaatgttcc ggcactgtgg caaagacaat aa                        1362

<210>  14
<211>  1404
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthesized gene

<400>  14
gtgagaagca aaaaattgtg gatcagcttg ttgtttgcgt taacgttaat ctttacgatg       60
gcgttcagca acatgagcgc gcaggctgct ggaaaagcac cgtcagatgg ccatggaccg      120
gttgcagcac cgcctccggc agcaagatca gcagcagatg cactggcagt ttcagcagtt      180
caaccggatg ttctgagagc aatgcaaaga gatctgggcc tgacaccggc agaagcaaga      240
caaagactgg caaatgaagc agaagcaggc gcaacagcag caagactgag acagagactt      300
gcaggctcat atgcaggcgc atgggttgaa ggccatgcat catcagttct gacagttgca      360
acaacaagag cagatgatgc agcagcaatt agagcatcag gcgctgaagc agatgttgtt      420
gcgcattcac tggcagcact ggatagaaca aaagcagcgc ttgatagagc agcgagaaca      480
gcggctgatg ttggcgttcc ggtttggtat gttgatgtta gaacaaatag cgttgttgtc      540
caagcagttg atcctggcgc agcagcatca ctggttggca gagtttcaga agcagataga      600
tcaagaatta gagttgtccc gacaagagaa agaccgcgtc cgctgtatga tattagaggc      660
ggagatgcgt attatatggg aggctcaggc agatgctcag ttggcttttc agttacaaga      720
ggcacacaag caggctttgc gacagcaggc cattgcggca gagctggcac aacaacaaca      780
ggctataata gagttgcaca aggctcattt caagcgtcaa catttccggg aagagataca      840
gcatgggtcg caacaaatac aaattggaca gcaacaccgt atgttaaagg cgcaggcgga      900
gcaaatgtta gagtcgcagg ctcagttcaa cagccggttg gcgcatcagt ttgcagatca      960
ggcagcacaa caggatggca ttgcggaaca attcaacaac ataatacaag cgtgacatat     1020
ccggaaggca caattacagg cgttacaaga acaagcgttt gcgcagaacc tggcgattca     1080
ggcggatcat atatttcagg ctcacaagca caaggcgtca catctggcgg atcaggcgat     1140
tgcagaagcg gaggcacaac atatcatcaa ccgattaatc cgctgctgca agcatatggc     1200
cttacactga caacgacgac aggccctggc gatccgggac cgggtgatcc ggatgaaccg     1260
ggtggcacat gggcagcagg cacagtttat agagcaggcg atcaagttac atatggcgga     1320
gcgacatata gatgccttca aggccatcaa gcacaggcag gctgggaacc gcctaatgtt     1380
ccggcactgt ggcaaagagg ctaa                                            1404

<210>  15
<211>  1377
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthesized gene

<400>  15
gtgagaagca aaaaattgtg gatcagcttg ttgtttgcgt taacgttaat ctttacgatg       60
gcgttcagca acatgagcgc gcaggctgct ggaaaagcac aaccgtcacc tggcgcagcg      120
cctggcgcac aatcagcagc aagagcactt ggcgcagcag aagcacaacc ggaactgctg      180
gcagcaatgg gcagagatct gggcctgaca agagcacaag cagaaagacg cctggttaat      240
gaagcggaag caggcgcagc ggcagcaaga ctgagagata gaattggcgg atcatttgca      300
ggcgcatggg ttgaaggcgc agaatcaggc tcactgacag ttgcaacaac aagagcagca      360
gatctggatg caattagagc ggcaggcgca acagcgagac tggttagaca tgatctgtca      420
tcactggaaa gagcaaaagc ggcacttgat agagcagctg gcgcagatgc accggttaga      480
tatgttgatg ttagagcaaa tcaactggtc gtcgaagaag ttagagcagg cgctggcgca      540
agactggcag cagcaacagg cgttccgaga gaacttgtta gagttgaaag atcaacagaa      600
gcaccgcgtc cgctgtatga tctgagaggc ggagatgcgt attatatggg aggcggaggc      660
agatgctcag ttggctttcc ggttacaaga ggcacaacac aaggctttgc aacagcaggc      720
cattgcggca gagcaggcca aacaacatca ggctataatc aagttgcaca aggctcattt      780
caaggctcag tttttccggg atcagatatg gcatgggtcg cagcaaattc atcatggaca      840
gcaacaccgt atgttaaagg cgcaggcgga gcgaatgttc aagttacagg cagcgttctg      900
cagccggttg gcgcaagcgt ttgcagatca ggatcaacaa caggctggca ttgcggaaca      960
attcaacaac ataatacaag cgtcacatat ccggaaggca caatttcagg cgttacaaga     1020
acaacagttt gcgcagaacc tggcgatagc ggaggctcat atatttcagg cagccaagca     1080
caaggcgtga catcaggcgg atcaggcaat tgctcatctg gcggaacaac atattttcaa     1140
ccgctgaatc cgattctgtc agcatatggc ctgacactga aaacaacggg cacagatccg     1200
ggaccgggtc cgggacctgg cgaacctgaa ccgggtggca catggaaagc aggcacagtt     1260
tatgctgcag gcgctacagt tacatatggc ggaagcacat atagatgcct gcaaggccat     1320
caagcacaaa caggatggga accgcctaat gttccggcac tgtggcaaag agtttaa        1377

<210>  16
<211>  1374
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthesized gene

<400>  16
gtgagaagca aaaaattgtg gatcagcttg ttgtttgcgt taacgttaat ctttacgatg       60
gcgttcagca acatgagcgc gcaggctgct ggaaaagcag cagatgcagc acctccggca      120
cctcctacgg cagcagcaac ggcaggcgtt gataatgcat caccgggact tttaagagca      180
atgcaaagag atcttggagt tacagaagca caagcacgcg cacgccttgc aaacgaagca      240
gaagcaggcg cagttgcagg acgccttaga attagcctcg ggggcgattt tgcaggcgca      300
tgggttcatg gccctgatag cgcaaaactg agcgttgcaa cgacagatgc atcagatcgc      360
gcagcaatcg aagctggcgg cgcacatgca gttgttgttc gccatacact gcctagactt      420
gatggcgcac tggcaaaact tgatgaagca gcatctgcag caccgtctac ggcagcagaa      480
gttccggttc gctatgttga tgttacggca aatagagtta cacttcaaac ggttcgccct      540
gcagcagcaa aagcactggt tgttgcagca ggcgttgatc ctgcattagt tcgcgttgaa      600
aaatctgcag aaagacctag accgctgtat gacttgcgag gcggagatgc atattatatg      660
aatggctctg gccgctgctc agttggcttt cctgttacga aaggaacaca acaaggattt      720
gcaacggcag gccattgtgg tcgtgttgga acgacgacga caggctataa tcaagttgca      780
caaggctcat ttcaagcatc tacatttccg ggccgcgata tggcatgggt tgcaacaaat      840
tctaattgga cggcaacacc ttatgttaaa ggaaatagcg gaaatgttca agttgcaggc      900
tctacacaag cagcagttgg cgcatctgtt tgccgctctg gatctacgac gggctggcat      960
tgcggaacaa tccaacaaca taatacgtca gttacgtatc ctgaaggaac gatttctgga     1020
gttacacgca cgacggtttg cgcagaaccg ggagatagcg gaggatcata tattagcgga     1080
tctcaagcac aaggcgttac gagcggagga tctggaaatt gccgctctgg cggaacgaca     1140
tattatcaac ctattaatcc tcttcttcaa aattatggac tgacacttaa aacgacgtca     1200
gatgatccgg gaccgggcga accgggagaa ccgggcggaa catgggcagc aggaacagtt     1260
tatgcagcag gcgcacaagt tacgtatgga ggcgcaacgt atcgctgctt acaaggccat     1320
caagcacaag caggctggga acctccgaat gttccggcac tgtggcaacg cgca           1374

<210>  17
<211>  29
<212>  PRT
<213>  Bacillus subtilis

<400>  17
Met Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Thr Leu 
1               5                   10                  15      
Ile Phe Thr Met Ala Phe Ser Asn Met Ser Ala Gln Ala 
            20                  25                  

<210>  18
<211>  191
<212>  PRT
<213>  Streptomyces sp. C009

<400>  18
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Ser Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ser Val Thr Arg Gly Thr Gln Ala Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Thr Thr Thr Gly Tyr Asn 
        35                  40                  45              
Arg Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Thr Ala Trp Val Ala Thr Asn Thr Asn Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Ala Asn Val Arg Val Ala Gly Ser Val Gln Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Thr Gly Val Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asp Cys Arg Ser Gly Gly Thr Thr Tyr His Gln Pro 
                165                 170                 175     
Ile Asn Pro Leu Leu Gln Ala Tyr Gly Leu Thr Leu Thr Thr Thr 
            180                 185                 190     

<210>  19
<211>  191
<212>  PRT
<213>  Streptomyces sp. C001

<400>  19
Tyr Asp Leu Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Gln Thr Thr Ser Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Ser Phe Gln Gly Ser Val Phe Pro Gly Ser Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Ala Asn Ser Ser Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Ser Ser Gly Gly Thr Thr Tyr Phe Gln Pro 
                165                 170                 175     
Leu Asn Pro Ile Leu Ser Ala Tyr Gly Leu Thr Leu Lys Thr Thr 
            180                 185                 190     

<210>  20
<211>  191
<212>  PRT
<213>  Streptomyces sp. C003

<400>  20
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Arg Gly Thr Thr Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Thr Thr Ser Gly Phe Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Ser Phe Gln Gly Ser Ile Phe Pro Gly Asn Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Ala Asn Thr Asn Trp Thr Ser Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ser Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Ser Ser Gly Gly Thr Thr Phe Phe Gln Pro 
                165                 170                 175     
Leu Asn Pro Leu Leu Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr 
            180                 185                 190     

<210>  21
<211>  190
<212>  PRT
<213>  Streptomyces sp. S055

<400>  21
Tyr Asp Leu Arg Gly Gly Asp Ala Tyr Tyr Met Asn Gly Ser Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Pro Val Thr Lys Gly Thr Gln Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Val Gly Thr Thr Thr Thr Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Thr Asn Ser Asn Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Asn Ser Gly Asn Val Gln Val Ala Gly Ser Thr Gln Ala Ala 
                85                  90                  95      
Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys 
            100                 105                 110         
Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr 
        115                 120                 125             
Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser 
    130                 135                 140                 
Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly 
145                 150                 155                 160 
Gly Ser Gly Asn Cys Arg Ser Gly Gly Thr Thr Tyr Tyr Gln Pro Ile 
                165                 170                 175     
Asn Pro Leu Leu Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr 
            180                 185                 190 

<210>  22
<211>  435
<212>  PRT
<213>  Streptomyces sp. C009

<400>  22
Ala Pro Ser Asp Gly His Gly Pro Val Ala Ala Pro Pro Pro Ala Ala 
1               5                   10                  15      
Arg Ser Ala Ala Asp Ala Leu Ala Val Ser Ala Val Gln Pro Asp Val 
            20                  25                  30          
Leu Arg Ala Met Gln Arg Asp Leu Gly Leu Thr Pro Ala Glu Ala Arg 
        35                  40                  45              
Gln Arg Leu Ala Asn Glu Ala Glu Ala Gly Ala Thr Ala Ala Arg Leu 
    50                  55                  60                  
Arg Gln Arg Leu Ala Gly Ser Tyr Ala Gly Ala Trp Val Glu Gly His 
65                  70                  75                  80  
Ala Ser Ser Val Leu Thr Val Ala Thr Thr Arg Ala Asp Asp Ala Ala 
                85                  90                  95      
Ala Ile Arg Ala Ser Gly Ala Glu Ala Asp Val Val Ala His Ser Leu 
            100                 105                 110         
Ala Ala Leu Asp Arg Thr Lys Ala Ala Leu Asp Arg Ala Ala Arg Thr 
        115                 120                 125             
Ala Ala Asp Val Gly Val Pro Val Trp Tyr Val Asp Val Arg Thr Asn 
    130                 135                 140                 
Ser Val Val Val Gln Ala Val Asp Pro Gly Ala Ala Ala Ser Leu Val 
145                 150                 155                 160 
Gly Arg Val Ser Glu Ala Asp Arg Ser Arg Ile Arg Val Val Pro Thr 
                165                 170                 175     
Arg Glu Arg Pro Arg Pro Leu Tyr Asp Ile Arg Gly Gly Asp Ala Tyr 
            180                 185                 190         
Tyr Met Gly Gly Ser Gly Arg Cys Ser Val Gly Phe Ser Val Thr Arg 
        195                 200                 205             
Gly Thr Gln Ala Gly Phe Ala Thr Ala Gly His Cys Gly Arg Ala Gly 
    210                 215                 220                 
Thr Thr Thr Thr Gly Tyr Asn Arg Val Ala Gln Gly Ser Phe Gln Ala 
225                 230                 235                 240 
Ser Thr Phe Pro Gly Arg Asp Thr Ala Trp Val Ala Thr Asn Thr Asn 
                245                 250                 255     
Trp Thr Ala Thr Pro Tyr Val Lys Gly Ala Gly Gly Ala Asn Val Arg 
            260                 265                 270         
Val Ala Gly Ser Val Gln Gln Pro Val Gly Ala Ser Val Cys Arg Ser 
        275                 280                 285             
Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln Gln His Asn Thr 
    290                 295                 300                 
Ser Val Thr Tyr Pro Glu Gly Thr Ile Thr Gly Val Thr Arg Thr Ser 
305                 310                 315                 320 
Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr Ile Ser Gly Ser 
                325                 330                 335     
Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asp Cys Arg Ser Gly 
            340                 345                 350         
Gly Thr Thr Tyr His Gln Pro Ile Asn Pro Leu Leu Gln Ala Tyr Gly 
        355                 360                 365             
Leu Thr Leu Thr Thr Thr Thr Gly Pro Gly Asp Pro Gly Pro Gly Asp 
    370                 375                 380                 
Pro Asp Glu Pro Gly Gly Thr Trp Ala Ala Gly Thr Val Tyr Arg Ala 
385                 390                 395                 400 
Gly Asp Gln Val Thr Tyr Gly Gly Ala Thr Tyr Arg Cys Leu Gln Gly 
                405                 410                 415     
His Gln Ala Gln Ala Gly Trp Glu Pro Pro Asn Val Pro Ala Leu Trp 
            420                 425                 430         
Gln Arg Gly 
        435 

<210>  23
<211>  426
<212>  PRT
<213>  Streptomyces sp. C001

<400>  23
Ala Gln Pro Ser Pro Gly Ala Ala Pro Gly Ala Gln Ser Ala Ala Arg 
1               5                   10                  15      
Ala Leu Gly Ala Ala Glu Ala Gln Pro Glu Leu Leu Ala Ala Met Gly 
            20                  25                  30          
Arg Asp Leu Gly Leu Thr Arg Ala Gln Ala Glu Arg Arg Leu Val Asn 
        35                  40                  45              
Glu Ala Glu Ala Gly Ala Ala Ala Ala Arg Leu Arg Asp Arg Ile Gly 
    50                  55                  60                  
Gly Ser Phe Ala Gly Ala Trp Val Glu Gly Ala Glu Ser Gly Ser Leu 
65                  70                  75                  80  
Thr Val Ala Thr Thr Arg Ala Ala Asp Leu Asp Ala Ile Arg Ala Ala 
                85                  90                  95      
Gly Ala Thr Ala Arg Leu Val Arg His Asp Leu Ser Ser Leu Glu Arg 
            100                 105                 110         
Ala Lys Ala Ala Leu Asp Arg Ala Ala Gly Ala Asp Ala Pro Val Arg 
        115                 120                 125             
Tyr Val Asp Val Arg Ala Asn Gln Leu Val Val Glu Glu Val Arg Ala 
    130                 135                 140                 
Gly Ala Gly Ala Arg Leu Ala Ala Ala Thr Gly Val Pro Arg Glu Leu 
145                 150                 155                 160 
Val Arg Val Glu Arg Ser Thr Glu Ala Pro Arg Pro Leu Tyr Asp Leu 
                165                 170                 175     
Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val 
            180                 185                 190         
Gly Phe Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly 
        195                 200                 205             
His Cys Gly Arg Ala Gly Gln Thr Thr Ser Gly Tyr Asn Gln Val Ala 
    210                 215                 220                 
Gln Gly Ser Phe Gln Gly Ser Val Phe Pro Gly Ser Asp Met Ala Trp 
225                 230                 235                 240 
Val Ala Ala Asn Ser Ser Trp Thr Ala Thr Pro Tyr Val Lys Gly Ala 
                245                 250                 255     
Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly 
            260                 265                 270         
Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr 
        275                 280                 285             
Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser 
    290                 295                 300                 
Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly 
305                 310                 315                 320 
Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser 
                325                 330                 335     
Gly Asn Cys Ser Ser Gly Gly Thr Thr Tyr Phe Gln Pro Leu Asn Pro 
            340                 345                 350         
Ile Leu Ser Ala Tyr Gly Leu Thr Leu Lys Thr Thr Gly Thr Asp Pro 
        355                 360                 365             
Gly Pro Gly Pro Gly Pro Gly Glu Pro Glu Pro Gly Gly Thr Trp Lys 
    370                 375                 380                 
Ala Gly Thr Val Tyr Ala Ala Gly Ala Thr Val Thr Tyr Gly Gly Ser 
385                 390                 395                 400 
Thr Tyr Arg Cys Leu Gln Gly His Gln Ala Gln Thr Gly Trp Glu Pro 
                405                 410                 415     
Pro Asn Val Pro Ala Leu Trp Gln Arg Val 
            420                 425     

<210>  24
<211>  421
<212>  PRT
<213>  Streptomyces sp. C003

<400>  24
Ala Pro Asp Gly Lys Pro Ala Ala Lys Thr Ala Ala Arg Thr Leu Ala 
1               5                   10                  15      
Ala Thr Ala Ala Gln Pro Glu Leu Leu Ser Ala Met Gln Arg Asp Leu 
            20                  25                  30          
Gly Leu Thr Arg Pro Gln Ala Leu Thr Arg Leu Ala Asn Glu Ala Glu 
        35                  40                  45              
Ala Gly Ala Thr Ala Ala Arg Leu Arg Gln Gly Leu Gly Gly Ala Phe 
    50                  55                  60                  
Ala Gly Ala Trp Val Asp Gly Pro Glu Ser Gly Thr Leu Thr Val Ala 
65                  70                  75                  80  
Thr Thr Arg Ala Ala Asp Ala Ala Ala Ile Arg Ala Thr Gly Ala Asp 
                85                  90                  95      
Ala Arg Leu Val Ser His Ser Leu Thr Ala Leu Glu Arg Ala Lys Arg 
            100                 105                 110         
Thr Leu Asp Gly Ala Ala Thr Ala Glu Ala Pro Val Arg Tyr Val Asp 
        115                 120                 125             
Val Arg Ala Asn Val Leu Val Val Glu Glu Thr Arg Ala Gly Ala Gly 
    130                 135                 140                 
Ala Arg Leu Val Arg Ala Thr Gly Val Pro Arg Asp Leu Val Arg Val 
145                 150                 155                 160 
Val Arg Thr Thr Ser Ala Pro Arg Pro Leu Tyr Asp Ile Arg Gly Gly 
                165                 170                 175     
Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe Ala 
            180                 185                 190         
Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys Gly 
        195                 200                 205             
Arg Ala Gly Thr Thr Thr Ser Gly Phe Asn Gln Val Ala Gln Gly Ser 
    210                 215                 220                 
Phe Gln Gly Ser Ile Phe Pro Gly Asn Asp Met Ala Trp Val Ala Ala 
225                 230                 235                 240 
Asn Thr Asn Trp Thr Ser Thr Pro Tyr Val Lys Gly Ser Gly Gly Ala 
                245                 250                 255     
Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ala Ser Val 
            260                 265                 270         
Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln Gln 
        275                 280                 285             
His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val Thr 
    290                 295                 300                 
Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr Ile 
305                 310                 315                 320 
Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn Cys 
                325                 330                 335     
Ser Ser Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro Leu Leu Gln 
            340                 345                 350         
Asn Tyr Gly Leu Thr Leu Lys Thr Thr Gly Ser Asp Pro Gly Pro Gly 
        355                 360                 365             
Pro Gly Glu Pro Gln Pro Gly Gly Thr Trp Ala Ala Gly Lys Val Tyr 
    370                 375                 380                 
Ala Ala Gly Asp Thr Val Thr Tyr Gly Gly Ala Thr Tyr Arg Cys Leu 
385                 390                 395                 400 
Gln Gly His Gln Ala Gln Thr Gly Trp Glu Pro Pro Asn Val Pro Ala 
                405                 410                 415     
Leu Trp Gln Arg Gln 
            420     

<210>  25
<211>  426
<212>  PRT
<213>  Streptomyces sp. S055

<400>  25
Ala Ala Asp Ala Ala Pro Pro Ala Pro Pro Thr Ala Ala Ala Thr Ala 
1               5                   10                  15      
Gly Val Asp Asn Ala Ser Pro Gly Leu Leu Arg Ala Met Gln Arg Asp 
            20                  25                  30          
Leu Gly Val Thr Glu Ala Gln Ala Arg Ala Arg Leu Ala Asn Glu Ala 
        35                  40                  45              
Glu Ala Gly Ala Val Ala Gly Arg Leu Arg Ile Ser Leu Gly Gly Asp 
    50                  55                  60                  
Phe Ala Gly Ala Trp Val His Gly Pro Asp Ser Ala Lys Leu Ser Val 
65                  70                  75                  80  
Ala Thr Thr Asp Ala Ser Asp Arg Ala Ala Ile Glu Ala Gly Gly Ala 
                85                  90                  95      
His Ala Val Val Val Arg His Thr Leu Pro Arg Leu Asp Gly Ala Leu 
            100                 105                 110         
Ala Lys Leu Asp Glu Ala Ala Ser Ala Ala Pro Ser Thr Ala Ala Glu 
        115                 120                 125             
Val Pro Val Arg Tyr Val Asp Val Thr Ala Asn Arg Val Thr Leu Gln 
    130                 135                 140                 
Thr Val Arg Pro Ala Ala Ala Lys Ala Leu Val Val Ala Ala Gly Val 
145                 150                 155                 160 
Asp Pro Ala Leu Val Arg Val Glu Lys Ser Ala Glu Arg Pro Arg Pro 
                165                 170                 175     
Leu Tyr Asp Leu Arg Gly Gly Asp Ala Tyr Tyr Met Asn Gly Ser Gly 
            180                 185                 190         
Arg Cys Ser Val Gly Phe Pro Val Thr Lys Gly Thr Gln Gln Gly Phe 
        195                 200                 205             
Ala Thr Ala Gly His Cys Gly Arg Val Gly Thr Thr Thr Thr Gly Tyr 
    210                 215                 220                 
Asn Gln Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg 
225                 230                 235                 240 
Asp Met Ala Trp Val Ala Thr Asn Ser Asn Trp Thr Ala Thr Pro Tyr 
                245                 250                 255     
Val Lys Gly Asn Ser Gly Asn Val Gln Val Ala Gly Ser Thr Gln Ala 
            260                 265                 270         
Ala Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
        275                 280                 285             
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
    290                 295                 300                 
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
305                 310                 315                 320 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
                325                 330                 335     
Gly Gly Ser Gly Asn Cys Arg Ser Gly Gly Thr Thr Tyr Tyr Gln Pro 
            340                 345                 350         
Ile Asn Pro Leu Leu Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr Ser 
        355                 360                 365             
Asp Asp Pro Gly Pro Gly Glu Pro Gly Glu Pro Gly Gly Thr Trp Ala 
    370                 375                 380                 
Ala Gly Thr Val Tyr Ala Ala Gly Ala Gln Val Thr Tyr Gly Gly Ala 
385                 390                 395                 400 
Thr Tyr Arg Cys Leu Gln Gly His Gln Ala Gln Ala Gly Trp Glu Pro 
                405                 410                 415     
Pro Asn Val Pro Ala Leu Trp Gln Arg Ala 
            420                 425     

<210>  26
<211>  453
<212>  PRT
<213>  Streptomyces albulus

<400>  26
Met Phe His Arg His Ala Arg Ala Ala Cys Val Gly Ala Val Thr Val 
1               5                   10                  15      
Gly Ala Leu Val Leu Thr Ala Leu Gln Gly Ala Ser Ala Ala Thr Pro 
            20                  25                  30          
Ala Pro Ala Ala Arg Ser Ala Ala Thr Thr Leu Ala Val Ser Ala Val 
        35                  40                  45              
Gln Pro Asp Val Leu Arg Ala Met Gln Arg Asp Leu Gly Leu Thr Gly 
    50                  55                  60                  
Ala Glu Ala Arg Val Arg Leu Ala Asn Glu Ala Glu Ala Gly Ala Thr 
65                  70                  75                  80  
Ala Ala Leu Leu Arg Gln Arg Leu Gly Gly Ser Phe Ala Gly Ala Trp 
                85                  90                  95      
Val Glu Gly Asp Val Ser Ser Val Leu Thr Val Ala Thr Thr Arg Ala 
            100                 105                 110         
Ala Asp Ala Ala Ala Ile Arg Ala Ser Gly Ala Glu Ala Asp Val Val 
        115                 120                 125             
Thr His Gly Leu Ala Gln Leu Asp Arg Thr Lys Ala Ala Leu Asp Arg 
    130                 135                 140                 
Ala Ala Arg Thr Thr Ala Thr Thr Gly Val Pro Val Trp Tyr Val Asp 
145                 150                 155                 160 
Val Arg Thr Asn Ser Val Val Val Gly Ala Ala Asp Arg Ala Ala Ala 
                165                 170                 175     
Ala Ala Leu Val Ala Arg Val Gly Glu Ala Asp Arg Ser Arg Ile Arg 
            180                 185                 190         
Val Val Pro Thr Arg Glu Arg Pro Arg Pro Leu Tyr Asp Ile Arg Gly 
        195                 200                 205             
Gly Asp Ala Tyr Tyr Met Gly Gly Ser Gly Arg Cys Ser Val Gly Phe 
    210                 215                 220                 
Ala Ile Thr Arg Gly Thr Gln Ala Gly Phe Ala Thr Ala Gly His Cys 
225                 230                 235                 240 
Gly Arg Ala Gly Thr Thr Thr Thr Gly Tyr Asn Gln Val Ala Gln Gly 
                245                 250                 255     
Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp Thr Ala Trp Val Ala 
            260                 265                 270         
Thr Ser Thr Asn Trp Thr Ala Thr Pro Tyr Val Lys Gly Ala Gly Gly 
        275                 280                 285             
Ala Asn Val Gln Val Thr Gly Ser Val Gln Gln Pro Val Gly Ala Ser 
    290                 295                 300                 
Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln 
305                 310                 315                 320 
Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val 
                325                 330                 335     
Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr 
            340                 345                 350         
Ile Ser Gly Thr Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asp 
        355                 360                 365             
Cys Arg Ser Gly Gly Thr Thr Tyr His Gln Pro Ile Asn Pro Leu Leu 
    370                 375                 380                 
Gln Ala Tyr Gly Leu Thr Leu Arg Thr Thr Thr Asp Pro Asp Asp Pro 
385                 390                 395                 400 
Gly Asp Pro Gly Glu Pro Gly Gly Thr Trp Ala Ala Gly Thr Val Tyr 
                405                 410                 415     
Arg Ala Gly Asp Gln Val Thr Tyr Gly Gly Ala Thr Tyr Arg Cys Leu 
            420                 425                 430         
Gln Gly His Gln Ala Gln Ala Gly Trp Glu Pro Pro Asn Val Pro Ala 
        435                 440                 445             
Leu Trp Gln Arg Gly 
    450             

<210>  27
<211>  456
<212>  PRT
<213>  Streptomyces sp. NRRL F-5193

<400>  27
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ala Leu Ala Ala Ala 
1               5                   10                  15      
Gly Met Val Leu Ala Gly Leu Gln Ala Gly Ser Ala Thr Ala Ala Gln 
            20                  25                  30          
Pro Ser Pro Gly Thr Gly Pro Gly Ala Leu Ser Ala Ala Arg Ala Leu 
        35                  40                  45              
Gly Ala Ala Glu Ala Arg Pro Glu Leu Leu Ala Ala Met Gly Arg Asp 
    50                  55                  60                  
Leu Gly Leu Thr Arg Ala Gln Ala Glu Arg Arg Leu Val Asn Glu Ala 
65                  70                  75                  80  
Glu Ala Gly Ala Ala Ala Ala Arg Leu Arg Asp Arg Leu Gly Gly Ser 
                85                  90                  95      
Phe Ala Gly Ala Trp Val Ala Gly Ala Glu Ser Gly Ser Leu Thr Val 
            100                 105                 110         
Ala Thr Thr Arg Ala Ala Asp Leu Ala Ala Ile Arg Ala Ala Gly Ala 
        115                 120                 125             
Glu Ala Ala Leu Val Arg His Gly Leu Pro Ala Leu Glu Arg Ala Lys 
    130                 135                 140                 
Ala Ala Leu Asp Arg Ala Ala Thr Ala Asp Ala Pro Val Arg Tyr Val 
145                 150                 155                 160 
Asp Ile Arg Ala Asn Ala Leu Val Val Glu Glu Thr Arg Ala Gly Ala 
                165                 170                 175     
Gly Lys Arg Leu Val Ala Ala Thr Gly Val Pro Ala Glu Leu Val Arg 
            180                 185                 190         
Val Val Arg Ser Ala Glu Ala Pro Arg Pro Leu Tyr Asp Leu Arg Gly 
        195                 200                 205             
Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe 
    210                 215                 220                 
Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys 
225                 230                 235                 240 
Gly Arg Ala Gly Gln Thr Thr Ser Gly Tyr Asn Gln Val Ala Gln Gly 
                245                 250                 255     
Ser Phe Gln Ala Ser Ile Phe Pro Gly Asn Asp Met Ala Trp Val Ala 
            260                 265                 270         
Ala Asn Ser Asn Trp Thr Ala Thr Pro Tyr Val Lys Gly Ala Gly Gly 
        275                 280                 285             
Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ala Ser 
    290                 295                 300                 
Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln 
305                 310                 315                 320 
Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val 
                325                 330                 335     
Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr 
            340                 345                 350         
Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn 
        355                 360                 365             
Cys Ser Ser Gly Gly Thr Thr Tyr Phe Gln Pro Leu Asn Pro Ile Leu 
    370                 375                 380                 
Ser Asn Tyr Gly Leu Thr Leu Lys Thr Thr Gly Thr Asp Pro Gly Pro 
385                 390                 395                 400 
Gly Pro Gly Pro Gly Glu Pro Glu Pro Gly Gly Thr Trp Lys Ala Gly 
                405                 410                 415     
Thr Val Tyr Ala Ala Gly Ala Thr Val Thr Tyr Gly Gly Ser Thr Tyr 
            420                 425                 430         
Arg Cys Leu Gln Gly His Gln Ala Gln Ala Gly Trp Glu Pro Pro Asn 
        435                 440                 445             
Val Pro Ala Leu Trp Gln Arg Val 
    450                 455     

<210>  28
<211>  451
<212>  PRT
<213>  Streptomyces exfoliatus

<400>  28
Met Leu Arg Arg His Thr Arg Ala Ala Cys Thr Ala Leu Val Ala Ala 
1               5                   10                  15      
Gly Met Ala Leu Ala Gly Leu Gln Ala Gly Thr Ala Thr Ala Ala Pro 
            20                  25                  30          
Asp Gly Asn Pro Ala Ala Lys Thr Ala Ala Gln Thr Leu Ala Ala Gly 
        35                  40                  45              
Ala Ala Gln Pro Glu Leu Leu Ser Ala Met Gln Arg Asp Leu Gly Leu 
    50                  55                  60                  
Thr Arg Pro Gln Ala Leu Thr Arg Leu Ala Asn Glu Ala Glu Ala Gly 
65                  70                  75                  80  
Ala Thr Ala Ala Arg Leu Arg Gln Gly Leu Gly Gly Ala Phe Ala Gly 
                85                  90                  95      
Ala Trp Val Asp Gly Pro Glu Ser Gly Thr Leu Thr Val Ala Thr Thr 
            100                 105                 110         
Arg Ala Ala Asp Ala Ala Val Ile Arg Ala Thr Gly Ala Asn Ala Arg 
        115                 120                 125             
Leu Val Ser His Thr Leu Thr Ala Leu Glu Arg Ala Lys Arg Ala Leu 
    130                 135                 140                 
Asp Gly Ala Ala Thr Ala Glu Ala Pro Val Arg Tyr Val Asp Val Arg 
145                 150                 155                 160 
Ala Asn Val Leu Val Val Glu Glu Thr Arg Pro Gly Ala Gly Ala Arg 
                165                 170                 175     
Leu Val Arg Ala Thr Gly Val Pro Arg Asp Leu Val Arg Val Val Arg 
            180                 185                 190         
Thr Ala Ser Ala Pro Arg Pro Leu Tyr Asp Ile Arg Gly Gly Asp Ala 
        195                 200                 205             
Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe Ala Val Thr 
    210                 215                 220                 
Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys Gly Arg Ala 
225                 230                 235                 240 
Gly Thr Thr Thr Ser Gly Phe Asn Gln Ala Ala Gln Gly Ser Phe Gln 
                245                 250                 255     
Gly Ser Ile Phe Pro Gly Asn Asp Met Ala Trp Val Ala Ala Asn Thr 
            260                 265                 270         
Asn Trp Thr Ser Thr Pro Tyr Val Lys Gly Ser Gly Gly Ala Asn Val 
        275                 280                 285             
Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ala Ser Val Cys Arg 
    290                 295                 300                 
Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln Gln His Asn 
305                 310                 315                 320 
Thr Ser Val Thr Tyr Pro Glu Gly Ile Ile Ser Gly Val Thr Arg Thr 
                325                 330                 335     
Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr Ile Ser Gly 
            340                 345                 350         
Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn Cys Ser Ser 
        355                 360                 365             
Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro Leu Leu Gln Asn Tyr 
    370                 375                 380                 
Gly Leu Thr Leu Lys Thr Thr Gly Ser Asp Pro Gly Pro Gly Pro Gly 
385                 390                 395                 400 
Glu Pro Gln Pro Gly Gly Thr Trp Ala Ala Gly Lys Val Tyr Ala Ala 
                405                 410                 415     
Gly Asp Thr Val Thr Tyr Gly Gly Gly Thr Tyr Arg Cys Leu Gln Gly 
            420                 425                 430         
His Gln Ala Gln Thr Gly Trp Glu Pro Pro Asn Val Pro Ala Leu Trp 
        435                 440                 445             
Gln Arg Gln 
    450     

<210>  29
<211>  459
<212>  PRT
<213>  Streptomyces albus

<400>  29
Met Leu His Arg His Ala Lys Ala Ala Gly Val Gly Ala Ala Ala Ala 
1               5                   10                  15      
Ala Leu Val Leu Thr Thr Leu Gln Gly Ala Ala Ser Ala Gln Gln Asp 
            20                  25                  30          
Gly Thr Pro Pro Gly Ala Val Ala His Thr Ala Ala Asp Thr Leu Ala 
        35                  40                  45              
Val Ser Ala Ala Gln Pro Glu Leu Leu Arg Ala Met Gln Arg Asp Leu 
    50                  55                  60                  
Gly Leu Thr Arg Ala Gln Ala Glu Arg Arg Leu Val Asn Glu Ala Glu 
65                  70                  75                  80  
Ala Gly Ala Thr Ala Ala Val Leu Arg Gln Arg Leu Gly Gly Ser Phe 
                85                  90                  95      
Ala Gly Ala Trp Val Glu Gly Ala Asp Ser Gly Thr Leu Thr Val Ala 
            100                 105                 110         
Thr Thr Arg Ala Ala Asp Ala Ala Ala Ile Arg Ala Ala Gly Ala Glu 
        115                 120                 125             
Ser Arg Thr Val Thr His Asn Leu Ala Glu Leu Asp Arg Thr Lys Ala 
    130                 135                 140                 
Ala Leu Asp Arg Ala Ala Glu Arg Asn Ser Ser Thr Asp Val Pro Val 
145                 150                 155                 160 
Trp Tyr Val Asp Val Arg Ala Asn Ala Val Val Val Arg Ala Val Glu 
                165                 170                 175     
Lys Ala Ala Ala Gln Thr Leu Ile Glu Ala Thr Ala Ala Asp Arg Asp 
            180                 185                 190         
Arg Ile Arg Val Val Pro Thr Gly Glu Gln Pro Arg Pro Leu Tyr Asp 
        195                 200                 205             
Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser 
    210                 215                 220                 
Val Gly Phe Ala Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala 
225                 230                 235                 240 
Gly His Cys Gly Arg Ala Gly Thr Ala Thr Ser Gly Tyr Asn Gln Val 
                245                 250                 255     
Ala Gln Gly Thr Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp Thr Ala 
            260                 265                 270         
Trp Val Ala Thr Asn Gly Asn Trp Thr Ser Thr Pro Tyr Val Lys Gly 
        275                 280                 285             
Gln Gly Gly Gln Asn Ile Gln Val Thr Gly Ser Val Gln Gln Pro Val 
    290                 295                 300                 
Gly Ala Ser Ile Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly 
305                 310                 315                 320 
Thr Ile Ser Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile 
                325                 330                 335     
Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly 
            340                 345                 350         
Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly 
        355                 360                 365             
Ser Gly Asp Cys Arg Ser Gly Gly Thr Thr Tyr His Gln Pro Val Asn 
    370                 375                 380                 
Pro Leu Leu Gln Gly Tyr Gly Leu Thr Leu Lys Thr Thr Val Asp Pro 
385                 390                 395                 400 
Gly Asp Pro Gly Asp Pro Gly Asp Pro Gly Glu Pro Gly Gly Thr Trp 
                405                 410                 415     
Ala Ala Gly Thr Val Tyr Gln Ala Gly Ala Gln Val Thr Tyr Gly Gly 
            420                 425                 430         
Ala Thr Tyr Arg Cys Leu Gln Gly His Gln Ala Gln Ala Gly Trp Glu 
        435                 440                 445             
Pro Pro Asn Ala Pro Ala Leu Trp Gln Arg Leu 
    450                 455                 

<210>  30
<211>  453
<212>  PRT
<213>  Streptomyces pristinaespiralis

<400>  30
Met Leu His Arg His Ala Lys Ala Ala Cys Val Gly Ala Ala Ala Ala 
1               5                   10                  15      
Ala Ala Leu Val Leu Thr Ser Leu Gln Gly Ala Ala Ser Ala Gln Pro 
            20                  25                  30          
Ala Gly Gly Ala Ala Pro Ser Ala Ala Asn Thr Leu Ala Val Ser Ala 
        35                  40                  45              
Ala Gln Pro Glu Leu Leu Arg Ala Met Gln Arg Asp Leu Gly Leu Thr 
    50                  55                  60                  
Arg Ala Glu Ala Glu Arg Arg Leu Val Asn Glu Ala Glu Ala Gly Ala 
65                  70                  75                  80  
Thr Ala Ala Val Leu Arg Gln Arg Leu Gly Asp Ser Phe Ala Gly Ala 
                85                  90                  95      
Trp Val Glu Gly Ala Asp Ser Gly Thr Leu Thr Val Ala Thr Thr Arg 
            100                 105                 110         
Ala Ala Asp Ala Ala Ala Ile Arg Ala Gly Gly Ala Glu Ala Arg Thr 
        115                 120                 125             
Val Thr His Thr Leu Ala Glu Leu Asp Arg Ala Lys Ala Ala Leu Asp 
    130                 135                 140                 
Arg Ala Ala Ala Arg Asp Ser Ser Thr Asp Val Pro Val Trp Tyr Val 
145                 150                 155                 160 
Asp Val Arg Ala Asn Ala Val Val Val Arg Ala Val Glu Arg Ser Ala 
                165                 170                 175     
Ala Gln Thr Leu Ile Gly Ala Ser Gly Ala Glu Arg Asp Leu Ile Arg 
            180                 185                 190         
Val Val Pro Thr Glu Glu Gln Pro Arg Pro Leu Tyr Asp Ile Arg Gly 
        195                 200                 205             
Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe 
    210                 215                 220                 
Ala Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys 
225                 230                 235                 240 
Gly Arg Ala Gly Thr Ser Thr Ser Gly Tyr Asn Gln Val Ala Gln Gly 
                245                 250                 255     
Thr Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp Thr Ala Trp Val Ala 
            260                 265                 270         
Ala Asn Ser Asn Trp Thr Ser Thr Pro Tyr Val Lys Gly Gln Ser Gly 
        275                 280                 285             
Gln Asn Ile Gln Val Thr Gly Ser Val Gln Gln Pro Val Gly Ala Ser 
    290                 295                 300                 
Ile Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Ser 
305                 310                 315                 320 
Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Thr Gly Val 
                325                 330                 335     
Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr 
            340                 345                 350         
Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asp 
        355                 360                 365             
Cys Arg Ser Gly Gly Thr Thr Phe His Gln Pro Ile Asn Pro Leu Leu 
    370                 375                 380                 
Gln Gly Tyr Gly Leu Thr Leu Lys Thr Thr Thr Asp Pro Gly Glu Pro 
385                 390                 395                 400 
Gly Glu Pro Gly Glu Pro Gly Gly Thr Trp Ala Ala Gly Thr Val Tyr 
                405                 410                 415     
Gln Ala Gly Ala Gln Val Thr Tyr Gly Gly Val Thr Tyr Arg Cys Leu 
            420                 425                 430         
Gln Gly His Gln Ala Gln Ala Gly Trp Glu Pro Pro Asn Val Pro Ala 
        435                 440                 445             
Leu Trp Gln Arg Leu 
    450             

<210>  31
<211>  451
<212>  PRT
<213>  Streptomyces venezuelae

<400>  31
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ala Leu Val Ala Ala 
1               5                   10                  15      
Gly Met Ala Leu Ala Gly Leu Gln Ala Gly Thr Ala Thr Ala Ala Pro 
            20                  25                  30          
Asp Gly Lys Pro Ala Ala Lys Thr Ala Ala Arg Thr Leu Ala Thr Ala 
        35                  40                  45              
Ala Ala Gln Pro Glu Leu Leu Ser Ala Met Gln Arg Asp Leu Gly Leu 
    50                  55                  60                  
Thr Arg Pro Gln Ala Leu Thr Arg Leu Ala Asn Glu Ala Glu Ala Gly 
65                  70                  75                  80  
Ala Thr Ala Ala Gly Leu Arg Gln Ser Leu Ala Gly Ala Phe Ala Gly 
                85                  90                  95      
Ala Trp Val Asp Gly Ala Glu Ser Gly Thr Leu Thr Val Ala Thr Thr 
            100                 105                 110         
Arg Ser Ala Asp Thr Ala Ala Ile Arg Ala Thr Gly Ala Asn Ala Arg 
        115                 120                 125             
Leu Val Pro His Ser Leu Thr Ala Leu Glu Arg Ala Lys Arg Ala Leu 
    130                 135                 140                 
Asp Arg Gly Ala Thr Ala Glu Ala Pro Val Arg Tyr Val Asp Val Arg 
145                 150                 155                 160 
Ala Asn Val Leu Val Val Glu Glu Thr Arg Ala Gly Ala Gly Ala Arg 
                165                 170                 175     
Leu Val Glu Ala Ala Gly Val Pro Arg Asp Leu Val Arg Val Val Arg 
            180                 185                 190         
Thr Asp Arg Ala Pro Arg Pro Leu Tyr Asp Ile Arg Gly Gly Asp Ala 
        195                 200                 205             
Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe Ala Val Thr 
    210                 215                 220                 
Arg Gly Ala Thr Gln Gly Phe Ala Thr Ala Gly His Cys Gly Arg Ala 
225                 230                 235                 240 
Gly Thr Thr Thr Ser Gly Phe Asn Gln Val Ala Gln Gly Ser Phe Gln 
                245                 250                 255     
Ala Ser Thr Phe Pro Gly Asn Asp Met Ala Trp Val Ala Ala Asn Thr 
            260                 265                 270         
Asn Trp Thr Ser Thr Pro Tyr Val Lys Gly Ser Gly Gly Ala Asn Val 
        275                 280                 285             
Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ala Ser Val Cys Arg 
    290                 295                 300                 
Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln Gln His Asn 
305                 310                 315                 320 
Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val Thr Arg Thr 
                325                 330                 335     
Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr Ile Ser Gly 
            340                 345                 350         
Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn Cys Ser Ser 
        355                 360                 365             
Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro Leu Leu Gln Asn Tyr 
    370                 375                 380                 
Gly Leu Thr Leu Lys Thr Thr Gly Thr Asp Pro Gly Pro Gly Pro Gly 
385                 390                 395                 400 
Glu Pro Gln Pro Gly Gly Thr Trp Ala Ala Gly Lys Val Tyr Ala Ala 
                405                 410                 415     
Gly Ala Thr Val Thr Tyr Gly Gly Ala Thr Tyr Arg Cys Leu Gln Gly 
            420                 425                 430         
His Gln Ala Gln Thr Gly Trp Glu Pro Pro Asn Val Pro Ala Leu Trp 
        435                 440                 445             
Gln Arg Gln 
    450     

<210>  32
<211>  456
<212>  PRT
<213>  Streptomyces venezuelae

<400>  32
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ala Leu Val Ala Ala 
1               5                   10                  15      
Gly Leu Ala Leu Ala Gly Leu Gln Ala Gly Thr Ala Ala Ala Val Pro 
            20                  25                  30          
Asp Ala Gly Glu Pro His Pro Ala Pro Thr Val Arg Thr Ala Ala Gln 
        35                  40                  45              
Thr Leu Gly Ala Asp Ala Ala Ala Pro Glu Val Leu Asp Ala Met Arg 
    50                  55                  60                  
Arg Asp Leu Gly Leu Ser His Ala Gln Ala Leu Thr Arg Leu Ala Asn 
65                  70                  75                  80  
Glu Ala Glu Ala Gly Ala Thr Ala Ala Arg Leu Arg Gln Gly Leu Gly 
                85                  90                  95      
Gly Ala Phe Ala Gly Ala Trp Val Asp Gly Ala Glu Ser Gly Thr Leu 
            100                 105                 110         
Thr Val Ala Thr Thr Arg Ser Ser Asp Ala Ala Ala Ile Arg Ala Thr 
        115                 120                 125             
Gly Ala Arg Ala Arg Leu Val Thr His Pro Leu Thr Ile Leu Glu Arg 
    130                 135                 140                 
Ala Lys Glu Arg Leu Asp Arg Ala Ala Thr Ala Asp Ala Pro Val Arg 
145                 150                 155                 160 
Tyr Val Asp Val Arg Ala Asn Val Leu Val Val Glu Glu Thr Lys Ala 
                165                 170                 175     
Gly Ala Gly Ala Arg Leu Leu Ala Ala Thr Gly Val Pro Arg Glu Leu 
            180                 185                 190         
Val Arg Val Val Arg Ser Gly Gln Ala Pro Arg Pro Leu Tyr Asp Leu 
        195                 200                 205             
Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val 
    210                 215                 220                 
Gly Phe Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly 
225                 230                 235                 240 
His Cys Gly Arg Ala Gly Thr Thr Thr Ser Gly Phe Asn Gln Val Ala 
                245                 250                 255     
Gln Gly Ser Phe Gln Gly Ser Ile Phe Pro Gly Asn Asp Met Ala Trp 
            260                 265                 270         
Val Ala Ala Asn Gly Asn Trp Thr Ala Thr Pro Tyr Val Lys Gly Ser 
        275                 280                 285             
Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly 
    290                 295                 300                 
Ser Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr 
305                 310                 315                 320 
Val Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser 
                325                 330                 335     
Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly 
            340                 345                 350         
Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser 
        355                 360                 365             
Gly Asn Cys Ser Ser Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro 
    370                 375                 380                 
Leu Leu Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr Gly Gly Asp Pro 
385                 390                 395                 400 
Gly Pro Gly Pro Gly Glu Pro Glu Pro Gly Gly Ser Trp Ala Ala Gly 
                405                 410                 415     
Thr Val Tyr Lys Ala Gly Asp Val Val Thr Tyr Gly Gly Ala Ser Tyr 
            420                 425                 430         
Arg Cys Leu Gln Gly His Gln Ala Gln Ala Gly Trp Gln Pro Pro Asn 
        435                 440                 445             
Val Pro Ala Leu Trp Gln Arg Leu 
    450                 455     

<210>  33
<211>  455
<212>  PRT
<213>  unknown

<220>
<223>  Streptomyces sp.

<400>  33
Met Leu Lys Arg His Ala Arg Ala Ala Cys Thr Ala Leu Ala Ala Ala 
1               5                   10                  15      
Gly Leu Leu Leu Ala Gly Thr Thr Ala Ala Gly Ala Ala Thr Pro Ala 
            20                  25                  30          
Ala Asp Pro Ala Ala Pro Gln Lys Ser Ala Thr Ala Thr Leu Arg Pro 
        35                  40                  45              
Gly Asp Ala Pro Ala Glu Leu Leu Thr Ala Leu Gln Arg Asp Leu Gly 
    50                  55                  60                  
Leu Thr Pro Thr Gln Ala Lys Asp Arg Leu Ala His Glu Ala Glu Ala 
65                  70                  75                  80  
Gly Ala Thr Ala Ala Arg Leu Arg Ala Arg Leu Gly Ala Ala Phe Ala 
                85                  90                  95      
Gly Ala Trp Val Asp Gly Ala Asp Ser Ala Thr Leu Thr Val Ala Thr 
            100                 105                 110         
Thr Arg Ala Ala Asp Ala Ala Ala Ile Arg Ala Ala Gly Ala Glu Ala 
        115                 120                 125             
Lys Leu Val Ser Arg Ser Leu Ala Asp Leu Asp Ala Val Arg Ala Gly 
    130                 135                 140                 
Leu Asp Arg Ala Ala Thr Ala Glu Thr Pro Val Arg Tyr Val Asp Pro 
145                 150                 155                 160 
Arg Thr Asn Thr Leu Val Val Glu Glu Thr Arg Pro Gly Ala Ala Ala 
                165                 170                 175     
Gly Leu Leu Ala Ala Thr Gly Thr Asp Pro Ala Leu Ala Thr Val Val 
            180                 185                 190         
Arg Thr Ala Ala Glu Gln Ala Pro Arg Pro Leu Tyr Asp Leu Arg Gly 
        195                 200                 205             
Gly Asp Ala Tyr Tyr Met Asn Gly Gln Gly Arg Cys Ser Val Gly Phe 
    210                 215                 220                 
Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys 
225                 230                 235                 240 
Gly Arg Ala Gly Thr Thr Thr Ser Gly Phe Asn Gln Val Ala Gln Gly 
                245                 250                 255     
Ser Phe Gln Ala Ser Val Phe Pro Gly Asn Asp Met Ala Trp Val Ala 
            260                 265                 270         
Ala Asn Thr Ser Trp Thr Ala Thr Pro Tyr Val Lys Gly Ser Gly Gly 
        275                 280                 285             
Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ser Ser 
    290                 295                 300                 
Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Val Gln 
305                 310                 315                 320 
Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val 
                325                 330                 335     
Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr 
            340                 345                 350         
Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asp 
        355                 360                 365             
Cys Thr Ser Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro Ile Leu 
    370                 375                 380                 
Ser Ala Tyr Gly Leu Thr Leu Lys Val Thr Gly Ser Asp Pro Gly Pro 
385                 390                 395                 400 
Gly Pro Gly Pro Gly Pro Gln Pro Gly Gly Thr Trp Lys Ala Gly Thr 
                405                 410                 415     
Val Tyr Ala Ala Gly Asp Thr Val Thr Tyr Gly Gly Ala Ala Tyr Arg 
            420                 425                 430         
Cys Leu Gln Gly His Gln Ala Gln Thr Gly Trp Glu Pro Ser Val Val 
        435                 440                 445             
Pro Ala Leu Trp Gln Lys Leu 
    450                 455 

<210>  34
<211>  456
<212>  PRT
<213>  Streptomyces flavochromogenes

<400>  34
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ser Leu Val Ala Ala 
1               5                   10                  15      
Gly Met Ala Leu Ala Gly Leu Gln Ala Gly Ser Ala Ala Ala Ala Pro 
            20                  25                  30          
Asp Gly Arg Asp Pro His Arg Ala Pro Thr Val Arg Thr Ala Ala Gln 
        35                  40                  45              
Ala Leu Gly Ala Asp Ser Ala Arg Pro Glu Leu Leu Asp Ala Met Arg 
    50                  55                  60                  
Arg Asp Leu Gly Leu Thr His Ser Gln Ala Arg Thr Arg Leu Ala Asn 
65                  70                  75                  80  
Glu Ala Glu Ala Gly Ala Thr Ala Ala Arg Leu Arg Gln Gly Leu Gly 
                85                  90                  95      
Gly Ala Phe Ala Gly Ala Trp Val Asp Gly Ala Glu Ala Gly Thr Leu 
            100                 105                 110         
Thr Val Ala Thr Thr Arg Ala Ala Asp Thr Pro Ala Ile Arg Ala Thr 
        115                 120                 125             
Gly Ala Arg Ala Arg Leu Val Thr His Ser Leu Thr Ala Leu Glu Arg 
    130                 135                 140                 
Ala Lys Gln Arg Leu Asp Arg Thr Ala Gly Thr Asp Ala Pro Val Arg 
145                 150                 155                 160 
Tyr Val Asp Val Arg Ala Asn Val Leu Val Val Glu Glu Thr Arg Ala 
                165                 170                 175     
Gly Ala Gly Ala Arg Leu Val Arg Ala Thr Gly Val Pro Arg Glu Leu 
            180                 185                 190         
Val Arg Val Val Arg Thr Gly Gln Ala Pro Arg Pro Leu Tyr Asp Ile 
        195                 200                 205             
Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val 
    210                 215                 220                 
Gly Phe Ala Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly 
225                 230                 235                 240 
His Cys Gly Arg Ala Gly Thr Thr Thr Ser Gly Phe Asn Gln Val Ala 
                245                 250                 255     
Gln Gly Ser Phe Gln Gly Ser Val Phe Pro Gly Asn Asp Met Ala Trp 
            260                 265                 270         
Val Ala Ala Asn Thr Asn Trp Thr Ser Thr Pro Tyr Val Lys Gly Ser 
        275                 280                 285             
Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly 
    290                 295                 300                 
Ser Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr 
305                 310                 315                 320 
Val Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser 
                325                 330                 335     
Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly 
            340                 345                 350         
Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser 
        355                 360                 365             
Gly Asn Cys Ser Ser Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro 
    370                 375                 380                 
Leu Leu Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr Gly Thr Asp Pro 
385                 390                 395                 400 
Gly Pro Gly Pro Gly Glu Pro Glu Pro Gly Gly Thr Trp Ala Ala Gly 
                405                 410                 415     
Lys Val Tyr Ala Ala Gly Asp Val Val Thr Tyr Gly Gly Ala Ser Tyr 
            420                 425                 430         
Arg Cys Leu Gln Gly His Gln Ala Gln Ala Gly Trp Gln Pro Pro Asn 
        435                 440                 445             
Val Pro Ala Leu Trp Gln Arg Leu 
    450                 455     

<210>  35
<211>  454
<212>  PRT
<213>  Streptomyces bikiniensis

<400>  35
Met Leu Arg Arg His Ala Arg Thr Ala Cys Thr Val Leu Ala Ala Ala 
1               5                   10                  15      
Gly Leu Ala Leu Ala Gly Leu Gln Ala Gly Ser Ala Thr Ala Ala Pro 
            20                  25                  30          
His Asp Lys Asp Arg Ala Pro Thr Val Arg Thr Ala Ala Asp Ala Leu 
        35                  40                  45              
Gly Ala Ala Ser Ala Gln Pro Glu Leu Leu Arg Ala Met Gln Arg Asp 
    50                  55                  60                  
Leu Gly Leu Thr Arg Ala Gln Ala Glu Asn Arg Leu Ala Asn Glu Ala 
65                  70                  75                  80  
Glu Ala Gly Ala Arg Ala Ala Gly Leu Arg Leu Asp Leu Gly Gly Ala 
                85                  90                  95      
Phe Ala Gly Ala Trp Val Asp Gly Ala Glu Ser Gly Thr Leu Thr Val 
            100                 105                 110         
Ala Thr Thr Arg Ala Ala Asp Ala Ala Ala Ile Arg Ala Ala Gly Ala 
        115                 120                 125             
His Ala Glu Val Val Thr His Gly Leu Ser Ala Leu Glu Arg Ala Lys 
    130                 135                 140                 
Glu Ala Leu Asp Arg Ala Ala Thr Ala Asp Val Pro Val Arg Tyr Val 
145                 150                 155                 160 
Asp Val Arg Ala Asn Val Leu Val Val Glu Glu Ala Arg Ala Gly Ala 
                165                 170                 175     
Gly Ala Arg Leu Val Ala Ala Thr Gly Val Pro Arg Asp Leu Val Lys 
            180                 185                 190         
Val Val Arg Thr Ala Glu Ala Pro Arg Pro Leu Tyr Asp Leu Arg Gly 
        195                 200                 205             
Gly Asp Ala Tyr Tyr Met Asn Gly Ser Gly Arg Cys Ser Val Gly Phe 
    210                 215                 220                 
Pro Ile Thr Lys Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys 
225                 230                 235                 240 
Gly Arg Ala Gly Thr Ser Thr Ser Gly Tyr Asn Gln Val Ala Gln Gly 
                245                 250                 255     
Ser Phe Gln Ala Ser Val Phe Pro Gly Ser Asp Met Ala Trp Val Ala 
            260                 265                 270         
Thr Asn Ser Asn Trp Thr Ala Thr Pro Tyr Val Lys Gly Ala Gly Gly 
        275                 280                 285             
Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ser Ser 
    290                 295                 300                 
Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Val Gln 
305                 310                 315                 320 
Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val 
                325                 330                 335     
Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr 
            340                 345                 350         
Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn 
        355                 360                 365             
Cys Ser Ser Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro Ile Leu 
    370                 375                 380                 
Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr Thr Asp Pro Gly Pro Gly 
385                 390                 395                 400 
Pro Gly Pro Glu Pro Glu Pro Gly Gly Thr Trp Ala Ala Gly Lys Val 
                405                 410                 415     
Tyr Lys Ala Gly Asp Thr Val Thr Tyr Gly Gly Ser Thr Tyr Arg Cys 
            420                 425                 430         
Leu Gln Gly His Gln Ala Gln Thr Gly Trp Glu Pro Ser Asn Val Pro 
        435                 440                 445             
Ala Leu Trp Gln Arg Val 
    450                 

<210>  36
<211>  456
<212>  PRT
<213>  Streptomyces griseus

<400>  36
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Ala Leu Ala Ala Ala 
1               5                   10                  15      
Gly Met Ala Leu Ala Gly Leu Gln Ala Gly Ser Ala Thr Ala Ala Gln 
            20                  25                  30          
Pro Ser Pro Gly Ser Ala Pro Ser Val Arg Ser Ala Ala His Ala Leu 
        35                  40                  45              
Gly Ala Asp Glu Ala Arg Pro Glu Leu Leu Ala Ala Met Gly Arg Asp 
    50                  55                  60                  
Leu Gly Leu Thr Arg Thr Gln Ala Glu His Arg Leu Val Asn Glu Ala 
65                  70                  75                  80  
Glu Ala Gly Ala Thr Ala Ala Arg Leu Arg Gln His Leu Gly Gly Ser 
                85                  90                  95      
Phe Ala Gly Ala Trp Val Ala Gly Ala Glu Ser Gly Ser Leu Thr Val 
            100                 105                 110         
Ala Thr Thr Arg Ala Ala Asp Leu Ala Ala Ile Arg Ala Ala Gly Ala 
        115                 120                 125             
Glu Ala Ala Leu Val Arg His Gly Leu Thr Ala Leu Glu Arg Ala Arg 
    130                 135                 140                 
Thr Ala Leu Asp Arg Ala Ala Thr Ala Asp Ala Pro Val Arg Tyr Val 
145                 150                 155                 160 
Asp Val Arg Ala Asn Val Leu Val Val Glu Glu Thr Arg Ala Gly Ala 
                165                 170                 175     
Gly Asp Arg Leu Val Ala Ala Thr Gly Val Pro Arg Glu Leu Val Arg 
            180                 185                 190         
Val Val Arg Ser Ala Gly Ala Pro Arg Pro Leu Tyr Asp Ile Arg Gly 
        195                 200                 205             
Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe 
    210                 215                 220                 
Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys 
225                 230                 235                 240 
Gly Arg Ala Gly Gln Ser Thr Ser Gly Phe Asn Gln Val Ala Gln Gly 
                245                 250                 255     
Thr Phe Gln Ala Ser Val Phe Pro Gly Asn Asp Met Ala Trp Val Ala 
            260                 265                 270         
Ala His Thr Asn Trp Thr Ser Thr Pro Tyr Val Lys Gly Ala Gly Gly 
        275                 280                 285             
Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ser Ser 
    290                 295                 300                 
Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln 
305                 310                 315                 320 
Gln His Asn Thr Ser Val Thr Tyr Gln Glu Gly Thr Val Ser Gly Val 
                325                 330                 335     
Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr 
            340                 345                 350         
Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Thr Gly Asn 
        355                 360                 365             
Cys Ser Ser Gly Gly Thr Thr Tyr Phe Gln Pro Leu Asn Pro Ile Leu 
    370                 375                 380                 
Ser Gly Tyr Gly Leu Thr Leu Lys Thr Thr Gly Ser Asp Pro Gly Pro 
385                 390                 395                 400 
Gly Pro Gly Pro Gly Glu Pro Gln Pro Gly Gly Thr Trp Thr Ala Gly 
                405                 410                 415     
Lys Val Tyr Ala Ala Gly Asp Thr Val Thr Tyr Gly Gly Ser Thr Tyr 
            420                 425                 430         
Arg Cys Leu Gln Ala His Gln Ala Gln Ala Gly Trp Glu Pro Ser Asn 
        435                 440                 445             
Val Pro Ala Leu Trp Gln Arg Ile 
    450                 455     

<210>  37
<211>  454
<212>  PRT
<213>  Streptomyces sp. NRRL_F-5727

<400>  37
Met Leu Arg Arg His Ala Arg Ala Ala Cys Thr Val Leu Ala Ala Ala 
1               5                   10                  15      
Gly Met Val Leu Ala Gly Leu Gln Ala Gly Ser Ala Thr Ala Ala Pro 
            20                  25                  30          
Pro Ser Pro Gly Thr Ala Pro Ala Val Gln Ser Ala Ala Arg Ala Leu 
        35                  40                  45              
Gly Ala Gly Glu Ala Arg Pro Glu Leu Leu Ala Ala Met Gly Arg Asp 
    50                  55                  60                  
Leu Gly Leu Thr Arg Ala Gln Ala Glu Arg Arg Leu Val Asn Glu Ala 
65                  70                  75                  80  
Glu Ala Gly Ala Thr Ala Ala Arg Leu Arg Asp Arg Leu Gly Gly Ala 
                85                  90                  95      
Phe Ala Gly Ala Trp Val Glu Gly Ala Glu Ser Gly Ser Leu Thr Val 
            100                 105                 110         
Ala Thr Thr Arg Ala Ala Asp Leu Ala Ala Ile Arg Ala Ala Gly Ala 
        115                 120                 125             
Thr Ala Arg Leu Val Arg His Asp Leu Ala Ala Leu Glu Arg Ala Lys 
    130                 135                 140                 
Glu Ser Leu Asp Arg Ala Ala Gly Ala Asp Ala Pro Val Arg Tyr Val 
145                 150                 155                 160 
Asp Val Arg Ala Asn Val Leu Val Val Glu Glu Thr Arg Ala Gly Ala 
                165                 170                 175     
Gly Ala Arg Leu Ala Ala Glu Thr Gly Val Ala Arg Glu Leu Val Arg 
            180                 185                 190         
Val Val Arg Ser Ala Glu Ala Pro Arg Pro Leu Tyr Asp Leu Arg Gly 
        195                 200                 205             
Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser Val Gly Phe 
    210                 215                 220                 
Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala Thr Ala Gly His Cys 
225                 230                 235                 240 
Gly Arg Ala Gly Gln Ser Thr Ser Gly Tyr Asn Gln Val Ala Gln Gly 
                245                 250                 255     
Thr Phe Gln Ala Ser Val Phe Pro Gly Asn Asp Met Ala Trp Val Ala 
            260                 265                 270         
Ala Asn Ser Ser Trp Thr Ala Thr Pro Tyr Val Lys Gly Ala Gly Gly 
        275                 280                 285             
Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln Pro Val Gly Ala Ser 
    290                 295                 300                 
Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly Thr Ile Gln 
305                 310                 315                 320 
Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile Ser Gly Val 
                325                 330                 335     
Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp Ser Gly Gly Ser Tyr 
            340                 345                 350         
Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly Ser Gly Asn 
        355                 360                 365             
Cys Ser Ser Gly Gly Thr Thr Phe Phe Gln Pro Leu Asn Pro Ile Leu 
    370                 375                 380                 
Ser Asn Tyr Gly Leu Thr Leu Arg Thr Ala Gly Thr Asp Pro Gly Pro 
385                 390                 395                 400 
Gly Pro Gly Glu Pro Glu Pro Gly Gly Thr Trp Lys Ala Gly Thr Val 
                405                 410                 415     
Tyr Ala Ala Gly Ala Thr Val Thr Tyr Gly Gly Ser Thr Tyr Arg Cys 
            420                 425                 430         
Leu Gln Gly His Gln Ala Gln Ala Gly Trp Glu Pro Pro Asn Val Pro 
        435                 440                 445             
Ala Leu Trp Gln Arg Val 
    450                 

<210>  38
<211>  458
<212>  PRT
<213>  Streptomyces sp. CNT372

<400>  38
Met Phe His Arg Pro Val Arg Ala Ala Cys Ala Ala Ala Val Ala Ala 
1               5                   10                  15      
Gly Ala Leu Val Leu Ala Ser Leu Gln Gly Tyr Ala Ala Ala Gln Pro 
            20                  25                  30          
Ser Ala Ala Ser Pro Gly Gly Gly Thr Ser Ala Ala Gly Thr Leu Ala 
        35                  40                  45              
Val Ser Ala Ala Gln Pro Gly Leu Lys Arg Ala Met Gln Arg Asp Leu 
    50                  55                  60                  
Gly Leu Thr Ala Ala Gln Ala Glu Arg Arg Leu Val Asn Glu Ala Glu 
65                  70                  75                  80  
Ala Gly Ala Ala Ala Ala Arg Leu Gln Gln Arg Leu Gly Ala Ser Phe 
                85                  90                  95      
Ala Gly Ala Trp Val Ser Gly Ala Glu Ser Gly Thr Leu Thr Val Ala 
            100                 105                 110         
Thr Thr Arg Ala Ala Asp His Ala Ala Val Arg Ala Glu Gly Ala Lys 
        115                 120                 125             
Pro Val Ala Ala Gly Ala Ser Leu Ala Glu Leu Asp Arg Ala Lys Ala 
    130                 135                 140                 
Ala Leu Asp Arg Ala Ala Ala Arg Ala Gly Ser Pro Ala Val Pro Val 
145                 150                 155                 160 
Trp Tyr Val Asp Val Arg Glu Asn Thr Val Val Val Gly Ala Arg Asn 
                165                 170                 175     
Thr Ala Ala Ala Glu Ala Leu Ile Ala Ala Ser Gly Ala Asp Arg Asp 
            180                 185                 190         
Arg Ile Arg Val Ala Ala Thr Gly Glu Ser Pro Arg Pro Leu Tyr Asp 
        195                 200                 205             
Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg Cys Ser 
    210                 215                 220                 
Val Gly Phe Ala Val Thr Arg Gly Thr Gln His Gly Phe Ala Thr Ala 
225                 230                 235                 240 
Gly His Cys Gly Arg Ala Gly Thr Ala Thr Ser Gly Phe Asn Gln Val 
                245                 250                 255     
Ala Gln Gly Thr Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp Thr Ala 
            260                 265                 270         
Trp Val Leu Thr Asn Ser Gln Trp Thr Ala Thr Pro Tyr Val Lys Gly 
        275                 280                 285             
Ala Gly Gly Gln Asn Val Gln Val Ala Gly Ser Val Gln Gln Pro Val 
    290                 295                 300                 
Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys Gly 
305                 310                 315                 320 
Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly Thr Ile 
                325                 330                 335     
Thr Gly Val Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp Ser Gly 
            340                 345                 350         
Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly Gly 
        355                 360                 365             
Ser Gly Asn Cys Arg Thr Gly Gly Thr Thr Tyr His Gln Pro Ile Asn 
    370                 375                 380                 
Pro Leu Leu Gln Ala Tyr Gly Leu Thr Leu Arg Thr Thr Thr Asp Pro 
385                 390                 395                 400 
Gly Pro Gly Pro Gly Glu Pro Pro Gly Glu Pro Gly Gly Thr Trp Ala 
                405                 410                 415     
Ala Gly Thr Val Tyr Ala Thr Gly Ala Gln Val Thr Tyr Gly Gly Ala 
            420                 425                 430         
Thr Tyr Arg Cys Leu Gln Gly His Gln Ala Gln Thr Gly Trp Glu Pro 
        435                 440                 445             
Pro Asn Val Pro Ala Leu Trp Gln Arg Leu 
    450                 455             

<210>  39
<211>  191
<212>  PRT
<213>  Streptomyces griseus

<400>  39
Ala Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Asn Gly Ser Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ser Val Thr Arg Gly Thr Gln Asn Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Val Gly Thr Thr Thr Asn Gly Val Asn 
        35                  40                  45              
Gln Gln Ala Gln Gly Thr Phe Gln Gly Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Ile Ala Trp Val Ala Thr Asn Ala Asn Trp Thr Pro Arg Pro Leu Val 
65                  70                  75                  80  
Asn Gly Tyr Gly Arg Gly Asp Val Thr Val Ala Gly Ser Thr Ala Ser 
                85                  90                  95      
Val Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln Leu Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Ser Ser Gly Gly Thr Thr Tyr Phe Gln Pro 
                165                 170                 175     
Ile Asn Pro Leu Leu Gln Ala Tyr Gly Leu Thr Leu Val Thr Ser 
            180                 185                 190     

<210>  40
<211>  275
<212>  PRT
<213>  Bacillus amyloliquefaciens

<400>  40
Ala Gln Ser Val Pro Tyr Gly Val Ser Gln Ile Lys Ala Pro Ala Leu 
1               5                   10                  15      
His Ser Gln Gly Tyr Thr Gly Ser Asn Val Lys Val Ala Val Ile Asp 
            20                  25                  30          
Ser Gly Ile Asp Ser Ser His Pro Asp Leu Lys Val Ala Gly Gly Ala 
        35                  40                  45              
Ser Met Val Pro Ser Glu Thr Asn Pro Phe Gln Asp Asn Asn Ser His 
    50                  55                  60                  
Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Ser Ile Gly 
65                  70                  75                  80  
Val Leu Gly Val Ala Pro Ser Ala Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      
Gly Ala Asp Gly Ser Gly Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu 
            100                 105                 110         
Trp Ala Ile Ala Asn Asn Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             
Pro Ser Gly Ser Ala Ala Leu Lys Ala Ala Val Asp Lys Ala Val Ala 
    130                 135                 140                 
Ser Gly Val Val Val Val Ala Ala Ala Gly Asn Glu Gly Thr Ser Gly 
145                 150                 155                 160 
Ser Ser Ser Thr Val Gly Tyr Pro Gly Lys Tyr Pro Ser Val Ile Ala 
                165                 170                 175     
Val Gly Ala Val Asp Ser Ser Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         
Gly Pro Glu Leu Asp Val Met Ala Pro Gly Val Ser Ile Gln Ser Thr 
        195                 200                 205             
Leu Pro Gly Asn Lys Tyr Gly Ala Leu Asn Gly Thr Ser Met Ala Ser 
    210                 215                 220                 
Pro His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser Lys His Pro Asn 
225                 230                 235                 240 
Trp Thr Asn Thr Gln Val Arg Ser Ser Leu Glu Asn Thr Thr Thr Lys 
                245                 250                 255     
Leu Gly Asp Ser Phe Tyr Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala 
            260                 265                 270         
Ala Ala Gln 
        275 

<210>  41
<211>  269
<212>  PRT
<213>  Bacillus lentus

<400>  41
Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala 
1               5                   10                  15      
His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          
Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser 
        35                  40                  45              
Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr 
    50                  55                  60                  
His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu 
65                  70                  75                  80  
Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala 
                85                  90                  95      
Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala 
            100                 105                 110         
Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser 
        115                 120                 125             
Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly 
    130                 135                 140                 
Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser 
145                 150                 155                 160 
Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln 
                165                 170                 175     
Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile 
            180                 185                 190         
Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr 
        195                 200                 205             
Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    210                 215                 220                 
Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
225                 230                 235                 240 
Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
                245                 250                 255     
Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            260                 265                 

<210>  42
<211>  191
<212>  PRT
<213>  Streptomyces albulus

<400>  42
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Ser Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Ile Thr Arg Gly Thr Gln Ala Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Thr Thr Thr Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Thr Ala Trp Val Ala Thr Ser Thr Asn Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Gln Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Thr Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asp Cys Arg Ser Gly Gly Thr Thr Tyr His Gln Pro 
                165                 170                 175     
Ile Asn Pro Leu Leu Gln Ala Tyr Gly Leu Thr Leu Arg Thr Thr 
            180                 185                 190     

<210>  43
<211>  191
<212>  PRT
<213>  Streptomyces sp. NRRL F-5193

<400>  43
Tyr Asp Leu Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Pro Val Thr Arg Gly Thr Thr Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Gln Thr Thr Ser Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Ser Phe Gln Ala Ser Ile Phe Pro Gly Asn Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Ala Asn Ser Asn Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Ser Ser Gly Gly Thr Thr Tyr Phe Gln Pro 
                165                 170                 175     
Leu Asn Pro Ile Leu Ser Asn Tyr Gly Leu Thr Leu Lys Thr Thr 
            180                 185                 190     

<210>  44
<211>  191
<212>  PRT
<213>  Streptomyces exfoliatus

<400>  44
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Arg Gly Thr Thr Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Thr Thr Ser Gly Phe Asn 
        35                  40                  45              
Gln Ala Ala Gln Gly Ser Phe Gln Gly Ser Ile Phe Pro Gly Asn Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Ala Asn Thr Asn Trp Thr Ser Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ser Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Ile Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Ser Ser Gly Gly Thr Thr Phe Phe Gln Pro 
                165                 170                 175     
Leu Asn Pro Leu Leu Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr 
            180                 185                 190     

<210>  45
<211>  191
<212>  PRT
<213>  Streptomyces albus

<400>  45
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Arg Gly Thr Thr Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Ala Thr Ser Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Thr Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Thr Ala Trp Val Ala Thr Asn Gly Asn Trp Thr Ser Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Gln Gly Gly Gln Asn Ile Gln Val Thr Gly Ser Val Gln Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Ile Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Ser Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asp Cys Arg Ser Gly Gly Thr Thr Tyr His Gln Pro 
                165                 170                 175     
Val Asn Pro Leu Leu Gln Gly Tyr Gly Leu Thr Leu Lys Thr Thr 
            180                 185                 190     

<210>  46
<211>  191
<212>  PRT
<213>  Streptomyces pristinaespiralis

<400>  46
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Arg Gly Thr Thr Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Ser Thr Ser Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Thr Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Thr Ala Trp Val Ala Ala Asn Ser Asn Trp Thr Ser Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Gln Ser Gly Gln Asn Ile Gln Val Thr Gly Ser Val Gln Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Ile Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Ser Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Thr Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asp Cys Arg Ser Gly Gly Thr Thr Phe His Gln Pro 
                165                 170                 175     
Ile Asn Pro Leu Leu Gln Gly Tyr Gly Leu Thr Leu Lys Thr Thr 
            180                 185                 190     

<210>  47
<211>  191
<212>  PRT
<213>  Streptomyces leeuwenhoekii

<400>  47
Tyr Asp Leu Arg Gly Gly Asp Ala Tyr Tyr Met Asn Gly Ser Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Pro Val Thr Arg Gly Thr Gln Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Ser Thr Thr Gly Tyr Asn 
        35                  40                  45              
Gln Ala Ala Gln Gly Thr Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Thr Asn Ser Asn Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Gln Asn Val Gln Val Thr Gly Ser Thr Gln Ala 
                85                  90                  95      
Pro Val Gly Ser Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln Leu Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Thr Gly Val Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Arg Thr Gly Gly Thr Thr Tyr Phe Gln Pro 
                165                 170                 175     
Leu Asn Pro Leu Leu Gln Ser Tyr Gly Leu Thr Leu Lys Thr Asn 
            180                 185                 190     

<210>  48
<211>  191
<212>  PRT
<213>  Streptomyces sp. CNT372

<400>  48
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Arg Gly Thr Gln His Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Ala Thr Ser Gly Phe Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Thr Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Thr Ala Trp Val Leu Thr Asn Ser Gln Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Gln Asn Val Gln Val Ala Gly Ser Val Gln Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Thr Gly Val Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Arg Thr Gly Gly Thr Thr Tyr His Gln Pro 
                165                 170                 175     
Ile Asn Pro Leu Leu Gln Ala Tyr Gly Leu Thr Leu Arg Thr Thr 
            180                 185                 190     

<210>  49
<211>  191
<212>  PRT
<213>  Streptomyces cyaneogriseus

<400>  49
Tyr Asp Leu Arg Gly Gly Asp Ala Tyr Tyr Met Asn Gly Ser Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Pro Ile Thr Arg Gly Thr Gln Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Ser Thr Thr Gly Tyr Asn 
        35                  40                  45              
Gln Ala Ala Gln Gly Thr Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Thr Asn Ser Asn Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Gln Asn Val Gln Val Ala Gly Ser Thr Gln Ala 
                85                  90                  95      
Pro Val Gly Ser Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Val Gln Gln Leu Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Thr Gly Val Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asp Cys Arg Thr Gly Gly Thr Thr Tyr Phe Gln Pro 
                165                 170                 175     
Ile Asn Pro Leu Leu Gln Thr Tyr Gly Leu Thr Leu Arg Thr Asn 
            180                 185                 190     

<210>  50
<211>  191
<212>  PRT
<213>  Streptomyces niveus

<400>  50
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Asn Gly Ser Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Lys Gly Thr Gln Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Pro Gly Thr Thr Thr Ser Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Thr Ala Trp Val Ala Thr Asn Thr Asn Trp Thr Ser Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Gln Gly Ala Ala Asn Val Gln Val Thr Gly Ser Thr Gln Ser 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Val Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Ser Ser Gly Gly Thr Thr Phe Tyr Gln Pro 
                165                 170                 175     
Val Asn Pro Leu Leu Gln Ala Tyr Ala Leu Thr Leu Lys Thr Thr 
            180                 185                 190     

<210>  51
<211>  191
<212>  PRT
<213>  Streptomyces venezuelae

<400>  51
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Arg Gly Ala Thr Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Thr Thr Ser Gly Phe Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Asn Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Ala Asn Thr Asn Trp Thr Ser Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ser Gly Gly Ala Asn Val Gln Val Thr Gly Ser Val Leu Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asn Cys Ser Ser Gly Gly Thr Thr Phe Phe Gln Pro 
                165                 170                 175     
Leu Asn Pro Leu Leu Gln Asn Tyr Gly Leu Thr Leu Lys Thr Thr 
            180                 185                 190     

<210>  52
<211>  190
<212>  PRT
<213>  Streptomyces sp. NRRL F-5755

<400>  52
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Arg Cys 
1               5                   10                  15      
Ser Val Gly Phe Ala Ile Thr Arg Gly Ser Gln Gln Gly Phe Ala Thr 
            20                  25                  30          
Ala Gly His Cys Gly Arg Ala Gly Thr Ser Thr Thr Gly Tyr Asn Gln 
        35                  40                  45              
Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp Thr 
    50                  55                  60                  
Ala Trp Val Ala Ala Asn Ser Asn Trp Thr Ser Thr Pro Tyr Val Lys 
65                  70                  75                  80  
Gly Gln Gly Gly Gln Asn Val Arg Val Ala Gly Ser Thr Gln Ala Ala 
                85                  90                  95      
Val Gly Ala Ser Ile Cys Arg Ser Gly Ser Thr Thr Gly Trp His Cys 
            100                 105                 110         
Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Gln Gly Thr 
        115                 120                 125             
Val Ser Gly Val Thr Arg Thr Ser Val Cys Ala Glu Pro Gly Asp Ser 
    130                 135                 140                 
Gly Gly Ser Phe Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser Gly 
145                 150                 155                 160 
Gly Ser Gly Asn Cys Arg Ser Gly Gly Thr Thr Phe Tyr Gln Pro Ile 
                165                 170                 175     
Asn Pro Leu Leu Gln Gly Tyr Gly Leu Thr Leu Lys Thr Gly 
            180                 185                 190 

<210>  53
<211>  191
<212>  PRT
<213>  Streptomyces fradiae

<400>  53
Tyr Asp Ile Arg Gly Gly Asp Ala Tyr His Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Lys Gly Thr Gln His Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Val Gly Thr Ser Thr Ser Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Thr Phe Gln Gly Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Met Ala Trp Val Ala Ala Asn Thr Asn Trp Arg Ser Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Gln Asn Val Gln Val Thr Gly Ser Thr Gln Ala 
                85                  90                  95      
Val Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asp Cys Arg Thr Gly Gly Thr Thr Tyr His Gln Pro 
                165                 170                 175     
Leu Asn Pro Leu Leu Gln Ala Tyr Ala Leu Thr Leu Thr Thr Thr 
            180                 185                 190     

<210>  54
<211>  191
<212>  PRT
<213>  artificial sequence

<220>
<223>  predicted catalytic domain consensus sequence

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = I or L

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  B is D or N

<220>
<221>  MISC_FEATURE
<222>  (177)..(177)
<223>  X= I or L

<400>  54
Tyr Asp Xaa Arg Gly Gly Asp Ala Tyr Tyr Met Gly Gly Gly Gly Arg 
1               5                   10                  15      
Cys Ser Val Gly Phe Ala Val Thr Arg Gly Thr Gln Gln Gly Phe Ala 
            20                  25                  30          
Thr Ala Gly His Cys Gly Arg Ala Gly Thr Thr Thr Thr Gly Tyr Asn 
        35                  40                  45              
Gln Val Ala Gln Gly Ser Phe Gln Ala Ser Thr Phe Pro Gly Arg Asp 
    50                  55                  60                  
Thr Ala Trp Val Ala Thr Asn Thr Asn Trp Thr Ala Thr Pro Tyr Val 
65                  70                  75                  80  
Lys Gly Ala Gly Gly Ala Asn Val Gln Val Ala Gly Ser Val Gln Gln 
                85                  90                  95      
Pro Val Gly Ala Ser Val Cys Arg Ser Gly Ser Thr Thr Gly Trp His 
            100                 105                 110         
Cys Gly Thr Ile Gln Gln His Asn Thr Ser Val Thr Tyr Pro Glu Gly 
        115                 120                 125             
Thr Ile Ser Gly Val Thr Arg Thr Thr Val Cys Ala Glu Pro Gly Asp 
    130                 135                 140                 
Ser Gly Gly Ser Tyr Ile Ser Gly Ser Gln Ala Gln Gly Val Thr Ser 
145                 150                 155                 160 
Gly Gly Ser Gly Asx Cys Arg Ser Gly Gly Thr Thr Tyr His Gln Pro 
                165                 170                 175     
Xaa Asn Pro Leu Leu Gln Ala Tyr Gly Leu Thr Leu Thr Thr Thr 
            180                 185                 190     

