                               SEQUENCE LISTING

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> METHODS OF MODULATING EXPRESSION OF TARGET NUCLEIC ACID SEQUENCES
      IN A CELL

<130> 010498.01059/WO

<140>
<141>

<150> 62/470,538
<151> 2017-03-13

<160> 37    

<170> PatentIn version 3.5

<210> 1
<211> 222
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
gaggccagcg gttccggacg ggctgacgca ttggacgatt ttgatctgga tatgctggga       60

agtgacgccc tcgatgattt tgaccttgac atgcttggtt cggatgccct tgatgacttt      120

gacctcgaca tgctcggcag tgacgccctt gatgatttcg acctggacat gctgattaac      180

tctagaagtt ccggatctcc gaaaaagaaa cgcaaagttg gt                         222


<210> 2
<211> 783
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
agccagtacc tgcccgacac cgacgaccgg caccggatcg aggaaaagcg gaagcggacc       60

tacgagacat tcaagagcat catgaagaag tcccccttca gcggccccac cgaccctaga      120

cctccaccta gaagaatcgc cgtgcccagc agatccagcg ccagcgtgcc aaaacctgcc      180

ccccagcctt accccttcac cagcagcctg agcaccatca actacgacga gttccctacc      240

atggtgttcc ccagcggcca gatctctcag gcctctgctc tggctccagc ccctcctcag      300

gtgctgcctc aggctcctgc tcctgcacca gctccagcca tggtgtctgc actggctcag      360

gcaccagcac ccgtgcctgt gctggctcct ggacctccac aggctgtggc tccaccagcc      420

cctaaaccta cacaggccgg cgagggcaca ctgtctgaag ctctgctgca gctgcagttc      480

gacgacgagg atctgggagc cctgctggga aacagcaccg atcctgccgt gttcaccgac      540

ctggccagcg tggacaacag cgagttccag cagctgctga accagggcat ccctgtggcc      600

cctcacacca ccgagcccat gctgatggaa taccccgagg ccatcacccg gctcgtgaca      660

ggcgctcaga ggcctcctga tccagctcct gcccctctgg gagcaccagg cctgcctaat      720

ggactgctgt ctggcgacga ggacttcagc tctatcgccg atatggattt ctcagccttg      780

ctg                                                                    783


<210> 3
<211> 570
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
cgggattcca gggaagggat gtttttgccg aagcctgagg ccggctccgc tattagtgac       60

gtgtttgagg gccgcgaggt gtgccagcca aaacgaatcc ggccatttca tcctccagga      120

agtccatggg ccaaccgccc actccccgcc agcctcgcac caacaccaac cggtccagta      180

catgagccag tcgggtcact gaccccggca ccagtccctc agccactgga tccagcgccc      240

gcagtgactc ccgaggccag tcacctgttg gaggatcccg atgaagagac gagccaggct      300

gtcaaagccc ttcgggagat ggccgatact gtgattcccc agaaggaaga ggctgcaatc      360

tgtggccaaa tggacctttc ccatccgccc ccaaggggcc atctggatga gctgacaacc      420

acacttgagt ccatgaccga ggatctgaac ctggactcac ccctgacccc ggaattgaac      480

gagattctgg ataccttcct gaacgacgag tgcctcttgc atgccatgca tatcagcaca      540

ggactgtcca tcttcgacac atctctgttt                                       570


<210> 4
<211> 483
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
gtgctgcctc aggctcctgc tcctgcacca gctccagcca tggtgtctgc actggctcag       60

gcaccagcac ccgtgcctgt gctggctcct ggacctccac aggctgtggc tccaccagcc      120

cctaaaccta cacaggccgg cgagggcaca ctgtctgaag ctctgctgca gctgcagttc      180

gacgacgagg atctgggagc cctgctggga aacagcaccg atcctgccgt gttcaccgac      240

ctggccagcg tggacaacag cgagttccag cagctgctga accagggcat ccctgtggcc      300

cctcacacca ccgagcccat gctgatggaa taccccgagg ccatcacccg gctcgtgaca      360

ggcgctcaga ggcctcctga tccagctcct gcccctctgg gagcaccagg cctgcctaat      420

ggactgctgt ctggcgacga ggacttcagc tctatcgccg atatggattt ctcagccttg      480

ctg                                                                    483


<210> 5
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
ctgtctgaag ctctgctgca gctgcagttc gacgacgagg atctgggagc cctgctggga       60

aacagcaccg atcctgccgt gttcaccgac ctggccagcg tggacaacag cgagttccag      120

cagctgctga accagggcat ccctgtggcc cctcacacca ccgagcccat gctgatggaa      180

taccccgagg ccatcacccg gctcgtgaca ggcgctcaga ggcctcctga tccagctcct      240

gcccctctgg gagcaccagg cctgcctaat ggactgctgt ctggcgacga ggacttcagc      300

tctatcgccg atatggattt ctcagccttg ctg                                   333


<210> 6
<211> 186
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
gcccctcaca ccaccgagcc catgctgatg gaataccccg aggccatcac ccggctcgtg       60

acaggcgctc agaggcctcc tgatccagct cctgcccctc tgggagcacc aggcctgcct      120

aatggactgc tgtctggcga cgaggacttc agctctatcg ccgatatgga tttctcagcc      180

ttgctg                                                                 186


<210> 7
<211> 600
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
agccagtacc tgcccgacac cgacgaccgg caccggatcg aggaaaagcg gaagcggacc       60

tacgagacat tcaagagcat catgaagaag tcccccttca gcggccccac cgaccctaga      120

cctccaccta gaagaatcgc cgtgcccagc agatccagcg ccagcgtgcc aaaacctgcc      180

ccccagcctt accccttcac cagcagcctg agcaccatca actacgacga gttccctacc      240

atggtgttcc ccagcggcca gatctctcag gcctctgctc tggctccagc ccctcctcag      300

gtgctgcctc aggctcctgc tcctgcacca gctccagcca tggtgtctgc actggctcag      360

gcaccagcac ccgtgcctgt gctggctcct ggacctccac aggctgtggc tccaccagcc      420

cctaaaccta cacaggccgg cgagggcaca ctgtctgaag ctctgctgca gctgcagttc      480

gacgacgagg atctgggagc cctgctggga aacagcaccg atcctgccgt gttcaccgac      540

ctggccagcg tggacaacag cgagttccag cagctgctga accagggcat ccctgtggcc      600


<210> 8
<211> 450
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
agccagtacc tgcccgacac cgacgaccgg caccggatcg aggaaaagcg gaagcggacc       60

tacgagacat tcaagagcat catgaagaag tcccccttca gcggccccac cgaccctaga      120

cctccaccta gaagaatcgc cgtgcccagc agatccagcg ccagcgtgcc aaaacctgcc      180

ccccagcctt accccttcac cagcagcctg agcaccatca actacgacga gttccctacc      240

atggtgttcc ccagcggcca gatctctcag gcctctgctc tggctccagc ccctcctcag      300

gtgctgcctc aggctcctgc tcctgcacca gctccagcca tggtgtctgc actggctcag      360

gcaccagcac ccgtgcctgt gctggctcct ggacctccac aggctgtggc tccaccagcc      420

cctaaaccta cacaggccgg cgagggcaca                                       450


<210> 9
<211> 300
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
agccagtacc tgcccgacac cgacgaccgg caccggatcg aggaaaagcg gaagcggacc       60

tacgagacat tcaagagcat catgaagaag tcccccttca gcggccccac cgaccctaga      120

cctccaccta gaagaatcgc cgtgcccagc agatccagcg ccagcgtgcc aaaacctgcc      180

ccccagcctt accccttcac cagcagcctg agcaccatca actacgacga gttccctacc      240

atggtgttcc ccagcggcca gatctctcag gcctctgctc tggctccagc ccctcctcag      300


<210> 10
<211> 300
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
agatccagcg ccagcgtgcc aaaacctgcc ccccagcctt accccttcac cagcagcctg       60

agcaccatca actacgacga gttccctacc atggtgttcc ccagcggcca gatctctcag      120

gcctctgctc tggctccagc ccctcctcag gtgctgcctc aggctcctgc tcctgcacca      180

gctccagcca tggtgtctgc actggctcag gcaccagcac ccgtgcctgt gctggctcct      240

ggacctccac aggctgtggc tccaccagcc cctaaaccta cacaggccgg cgagggcaca      300


<210> 11
<211> 348
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
ccactggatc cagcgcccgc agtgactccc gaggccagtc acctgttgga ggatcccgat       60

gaagagacga gccaggctgt caaagccctt cgggagatgg ccgatactgt gattccccag      120

aaggaagagg ctgcaatctg tggccaaatg gacctttccc atccgccccc aaggggccat      180

ctggatgagc tgacaaccac acttgagtcc atgaccgagg atctgaacct ggactcaccc      240

ctgaccccgg aattgaacga gattctggat accttcctga acgacgagtg cctcttgcat      300

gccatgcata tcagcacagg actgtccatc ttcgacacat ctctgttt                   348


<210> 12
<211> 198
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gacctttccc atccgccccc aaggggccat ctggatgagc tgacaaccac acttgagtcc       60

atgaccgagg atctgaacct ggactcaccc ctgaccccgg aattgaacga gattctggat      120

accttcctga acgacgagtg cctcttgcat gccatgcata tcagcacagg actgtccatc      180

ttcgacacat ctctgttt                                                    198


<210> 13
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
agcctcgcac caacaccaac cggtccagta catgagccag tcgggtcact gaccccggca       60

ccagtccctc agccactgga tccagcgccc gcagtgactc ccgaggccag tcacctgttg      120

gaggatcccg atgaagagac gagccaggct gtcaaagccc ttcgggagat ggccgatact      180

gtgattcccc agaaggaaga ggctgcaatc tgtggccaaa tggacctttc ccatccgccc      240

ccaaggggcc atctggatga gctgacaacc acacttgagt ccatgaccga ggatctgaac      300

ctggactcac ccctgacccc ggaattgaac gagattctgg ataccttcct gaacgacgag      360

tgcctcttgc atgcc                                                       375


<210> 14
<211> 303
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
ccactggatc cagcgcccgc agtgactccc gaggccagtc acctgttgga ggatcccgat       60

gaagagacga gccaggctgt caaagccctt cgggagatgg ccgatactgt gattccccag      120

aaggaagagg ctgcaatctg tggccaaatg gacctttccc atccgccccc aaggggccat      180

ctggatgagc tgacaaccac acttgagtcc atgaccgagg atctgaacct ggactcaccc      240

ctgaccccgg aattgaacga gattctggat accttcctga acgacgagtg cctcttgcat      300

gcc                                                                    303


<210> 15
<211> 228
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
gctgtcaaag cccttcggga gatggccgat actgtgattc cccagaagga agaggctgca       60

atctgtggcc aaatggacct ttcccatccg cccccaaggg gccatctgga tgagctgaca      120

accacacttg agtccatgac cgaggatctg aacctggact cacccctgac cccggaattg      180

aacgagattc tggatacctt cctgaacgac gagtgcctct tgcatgcc                   228


<210> 16
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
gacctttccc atccgccccc aaggggccat ctggatgagc tgacaaccac acttgagtcc       60

atgaccgagg atctgaacct ggactcaccc ctgaccccgg aattgaacga gattctggat      120

accttcctga acgacgagtg cctcttgcat gcc                                   153


<210> 17
<211> 74
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu 
1               5                   10                  15      


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            20                  25                  30          


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
        35                  40                  45              


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Ser Arg Ser Ser 
    50                  55                  60                  


Gly Ser Pro Lys Lys Lys Arg Lys Val Gly 
65                  70                  


<210> 18
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys 
1               5                   10                  15      


Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro 
            20                  25                  30          


Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val 
        35                  40                  45              


Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr 
    50                  55                  60                  


Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr 
65                  70                  75                  80  


Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro 
                85                  90                  95      


Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro 
            100                 105                 110         


Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu 
        115                 120                 125             


Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr 
    130                 135                 140                 


Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe 
145                 150                 155                 160 


Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala 
                165                 170                 175     


Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu 
            180                 185                 190         


Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu 
        195                 200                 205             


Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg 
    210                 215                 220                 


Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn 
225                 230                 235                 240 


Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp 
                245                 250                 255     


Phe Ser Ala Leu Leu 
            260     


<210> 19
<211> 190
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser 
1               5                   10                  15      


Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg 
            20                  25                  30          


Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu 
        35                  40                  45              


Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val 
    50                  55                  60                  


Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro 
65                  70                  75                  80  


Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu 
                85                  90                  95      


Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile 
            100                 105                 110         


Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His 
        115                 120                 125             


Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser 
    130                 135                 140                 


Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn 
145                 150                 155                 160 


Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met 
                165                 170                 175     


His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
            180                 185                 190 


<210> 20
<211> 161
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser 
1               5                   10                  15      


Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro 
            20                  25                  30          


Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu 
        35                  40                  45              


Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp 
    50                  55                  60                  


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp 
65                  70                  75                  80  


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
                85                  90                  95      


Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro 
            100                 105                 110         


Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro 
        115                 120                 125             


Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser 
    130                 135                 140                 


Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu 
145                 150                 155                 160 


Leu 
    


<210> 21
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly 
1               5                   10                  15      


Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala 
            20                  25                  30          


Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro 
        35                  40                  45              


Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala 
    50                  55                  60                  


Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro 
65                  70                  75                  80  


Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp 
                85                  90                  95      


Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
            100                 105                 110     


<210> 22
<211> 62
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile 
1               5                   10                  15      


Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala 
            20                  25                  30          


Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu 
        35                  40                  45              


Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
    50                  55                  60          


<210> 23
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys 
1               5                   10                  15      


Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro 
            20                  25                  30          


Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val 
        35                  40                  45              


Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr 
    50                  55                  60                  


Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr 
65                  70                  75                  80  


Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro 
                85                  90                  95      


Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro 
            100                 105                 110         


Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu 
        115                 120                 125             


Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr 
    130                 135                 140                 


Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe 
145                 150                 155                 160 


Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala 
                165                 170                 175     


Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu 
            180                 185                 190         


Leu Asn Gln Gly Ile Pro Val Ala 
        195                 200 


<210> 24
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys 
1               5                   10                  15      


Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro 
            20                  25                  30          


Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val 
        35                  40                  45              


Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr 
    50                  55                  60                  


Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr 
65                  70                  75                  80  


Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro 
                85                  90                  95      


Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro 
            100                 105                 110         


Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu 
        115                 120                 125             


Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr 
    130                 135                 140                 


Gln Ala Gly Glu Gly Thr 
145                 150 


<210> 25
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys 
1               5                   10                  15      


Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro 
            20                  25                  30          


Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val 
        35                  40                  45              


Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr 
    50                  55                  60                  


Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr 
65                  70                  75                  80  


Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro 
                85                  90                  95      


Ala Pro Pro Gln 
            100 


<210> 26
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe 
1               5                   10                  15      


Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val 
            20                  25                  30          


Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro 
        35                  40                  45              


Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met 
    50                  55                  60                  


Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro 
65                  70                  75                  80  


Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala 
                85                  90                  95      


Gly Glu Gly Thr 
            100 


<210> 27
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu 
1               5                   10                  15      


Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu 
            20                  25                  30          


Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly 
        35                  40                  45              


Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu 
    50                  55                  60                  


Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro 
65                  70                  75                  80  


Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu 
                85                  90                  95      


Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp 
            100                 105                 110         


Thr Ser Leu Phe 
        115     


<210> 28
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr 
1               5                   10                  15      


Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr 
            20                  25                  30          


Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu 
        35                  40                  45              


Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser 
    50                  55                  60                  


Leu Phe 
65      


<210> 29
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser 
1               5                   10                  15      


Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val 
            20                  25                  30          


Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser 
        35                  40                  45              


Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln 
    50                  55                  60                  


Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro 
65                  70                  75                  80  


Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr 
                85                  90                  95      


Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile 
            100                 105                 110         


Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala 
        115                 120                 125 


<210> 30
<211> 101
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu 
1               5                   10                  15      


Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu 
            20                  25                  30          


Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly 
        35                  40                  45              


Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu 
    50                  55                  60                  


Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro 
65                  70                  75                  80  


Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu 
                85                  90                  95      


Cys Leu Leu His Ala 
            100     


<210> 31
<211> 76
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys 
1               5                   10                  15      


Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro Pro 
            20                  25                  30          


Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr Glu 
        35                  40                  45              


Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu 
    50                  55                  60                  


Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala 
65                  70                  75      


<210> 32
<211> 51
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr 
1               5                   10                  15      


Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr 
            20                  25                  30          


Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu 
        35                  40                  45              


Leu His Ala 
    50      


<210> 33
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
tacttatata agggggtggg ggcgcgttcg tcctcagtcg cgatcgaaca ctcgagccga       60

gcagacgtgc ctacggaccg                                                   80


<210> 34
<211> 256
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
taggtcttga aaggagtggg aattggctcc ggtgcccgtc agtgggcaga gcgcacatcg       60

cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gatccggtgc ctagagaagg      120

tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt      180

gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt      240

gccgccagaa cacagg                                                      256


<210> 35
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
aaataaaata cgaaatg                                                      17


<210> 36
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
aaataaaata cgaaatgaaa taaaatacga aatg                                   34


<210> 37
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
aataaaatat ctttattttc attacatctg tgtgttggtt ttttgtgtg                   49


