﻿SEQUENCE LISTING
<110> 江苏融泰生物技术有限公司
<120>一种融合蛋白及其制备方法和其应用
<160>24
<170>  Patent In version 3.5
<210>  1
<211>  3
<212>  PRT
<213>  人工序列
<400>  1
Arg Gly Asp

<210>  2
<211>  9 
<212>  DNA
<213>  人工序列
<400>  2
    cgtggtgac    9

<210>  3
<211>  50
<212>  PRT
<213>  人工序列（EDSM-Y对应的氨基酸序列）
<400>  3
Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser Gly
1              5               10                15    
Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln Ala 
           20               25                30       
Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Gly Gly Gly Gly Arg 
       35                40               45
Gly Asp
    50

<210>  4
<211>  150
<212>  DNA
<213>  人工序列
<400>  4
ttccaacctg ttcttcacct tgttgctctt aactctcctc tttctggtgg tatgcgtggt     60
atccgtggtg ctgacttcca atgcttccaa caagctcgtg ctgttggtct tgctggtact  120
ttccgtgctg gtggtggtgg tcgtggtgac 150

<210>  5
<211>  50
<212>  PRT
<213>  人工序列
<400>  5
Arg Gly Asp Gly Gly Gly Gly Phe Gln Pro Val Leu His Leu Val Ala 
1               5               10                15      
Leu Asn Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp 
           20               25               30          
Phe Gln Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe 
        35               40               45              
Arg Ala
    50

<210>  6
<211>  150
<212>  DNA
<213>  人工序列
<400>  6
cgtggtgacg gtggtggtgg tttccaacct gttcttcacc ttgttgctct taactctcct       60
ctttctggtg gtatgcgtgg tatccgtggt gctgacttcc aatgcttcca acaagctcgt      120
gctgttggtc ttgctggtac tttccgtgct  150

<210>  7
<211>  232
<212>  PRT
<213>  人工序列
<400>  7
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1             5                10               15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
           20               25               30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35              40               45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50               55               60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65               70                75               80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
              85               90               95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
          100               105              110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
       115             120             125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130              135             140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145              150               155              160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
             165               170              175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
          180               185             190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
      195               200              205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
   210              215              220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225              230   

<210>  8
<211>  696
<212>  DNA
<213>  人工序列
<400>  8
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60
gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180
aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag    240
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat       300
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     360
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     420
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct    540
cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc       600
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac       660
tacacgcaga agagcctctc cctgtctccg ggtaaa                            696

<210>  9
<211>  228
<212>  PRT
<213>  人工序列
<400>  9
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1              5                10               15      
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
          20               25                30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
      35                40               45              
His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50               55                60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                70               75               80  
Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
              85               90               95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
          100               105              110         
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
     115              120               125             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130              135              140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145              150               155             160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
             165               170               175     
Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
          180              185               190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
       195              200               205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210             215               220                 
Ser Pro Gly Lys
225

<210>  10
<211>  684
<212>  DNA
<213>  人工序列
<400>  10
gagcgcaaat gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca      60
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc        120
acgtgcgtgg tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg      180
gacggcgtgg aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg     240
ttccgtgtgg tcagcgtcct caccgtcgtg caccaggact ggctgaacgg caaggagtac       300
aagtgcaagg tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc       360
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     420
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catctccgtg       480
gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc catgctggac     540
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag       600
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag       660
agcctctccc tgtctccggg taaa                                       684

<210>  11
<211>  229
<212>  PRT
<213>  人工序列
<400>  11
Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
1             5                10               15      
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
          20               25               30          
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
       35              40                45              
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
   50                55               60                  
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
65               70                75               80  
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
              85               90               95      
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
           100              105              110         
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
      115            120               125             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
   130              135              140                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145              150              155              160 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
             165               170              175     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
          180              185              190         
Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
       195              200              205             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
   210              215              220                 
Ser Leu Ser Leu Gly
225

<210>  12
<211>  687
<212>  DNA
<213>  人工序列
<400>  12
gccgagtcta agtacggccc tccttgccca ccttgccctg ctccagaagc tgctggcggc        60
ccttccgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatctc ccggaccccc        120
gaagtgacct gcgtggtggt ggatgtgtcc caggaagatc ccgaggtgca gttcaattgg       180
tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagttcaac     240
tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa       300
gagtacaagt gcaaggtgtc caacaagggc ctgccctcca gcatcgaaaa gaccatctcc      360
aaggccaagg gccagccccg ggaaccccag gtgtacacac tgcctccaag ccaggaagag    420
atgaccaaga accaggtgtc cctgacctgt ctcgtgaagg gcttctaccc ctccgatatc        480
gccgtggaat gggagtccaa cggccagcct gagaacaact acaagaccac cccccctgtg     540
ctggactccg acggctcctt cttcctgtac tcccgcctga ccgtggacaa gtccagatgg        600
caggaaggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc       660
cagaagtccc tgtccctgtc tctg                                        684

<210>  13
<211>  245
<212>  PRT
<213>  人工序列
<400>  13
Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys 
1              5                10                15      
Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His 
           20               25               30          
Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
       35               40               45              
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
   50               55               60                  
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65               70               75                80  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
             85                90               95      
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
          100              105              110         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
       115              120               125             
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
   130            135               140                 
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145              150              155               160 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
             165               170              175     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
          180              185               190         

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
      195               200              205             
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
   210              215               220                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225              230              235              240 
Leu Ser Leu Gly Lys
             245

<210>  14
<211>  150
<212>  DNA
<213>  人工序列
<400>  14
agaaatactg gcagaggcgg cgaggaaaag aagaaagaga aagaaaaaga ggaacaggaa   60
gagagagaga ctaagacccc cgagtgcccc tcccacacac agcctctggg cgtgttcctg      120
tttcccccaa agcccaagga caccctgatg atctcccgga cccccgaagt gacctgcgtg       180
gtggtggatg tgtcccagga agatcccgag gtgcagttca attggtacgt ggacggcgtg       240
gaagtgcaca acgccaagac caagccccgc gaggaacagt tcaactccac ctaccgggtg      300
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag       360
gtgtccaaca agggcctgcc ctccagcatc gaaaagacca tctccaaggc caagggccag       420
ccccgggaac cccaggtgta cacactgcct ccaagccagg aagaaatgac caagaaccag      480
gtgtccctga cctgtctcgt gaagggcttc tacccctccg atatcgccgt ggaatgggag         540
tccaacggcc agcctgagaa caactacaag accacccccc ctgtgctgga ctccgacggc       600
tccttcttcc tgtactcccg cctgaccgtg gacaagtcca gatggcagga aggcaacgtg         660
ttctcctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtcc         720
ctgtctctgg gcaag                                                 735

<210>  15
<211> 297
<212>  PRT
<213>  人工序列
<400>  15
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1             5                10               15      

Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
          20                25               30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35              40               45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
   50               55                60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65               70                75               80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
              85               90               95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
          100               105              110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
      115              120             125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130              135             140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145              150               155              160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
             165              170               175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
          180              185              190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
      195               200              205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
   210              215              220                 
Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225             230               235              240 
Gly Ser Gly Gly Gly Gly Ser Phe Gln Pro Val Leu His Leu Val Ala 
             245              250               255     
Leu Asn Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp 
          260              265              270         
Phe Gln Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe 
       275              280              285             
Arg Ala Gly Gly Gly Gly Arg Gly Asp 
290              295
 
<210>  16
<211>  891
<212>  DNA
<213>  人工序列
<400>  16
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60
gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180
aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag    240
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat       300
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     360
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     420
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc       480
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     540
cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc       600
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac       660
tacacgcaga agagcctctc cctgtctccg ggtaaaggcg gcggaggatc tggcggaggc     720
ggttctggtg gtggtggctc tttccaacct gttcttcacc ttgttgctct taactctcct           780
ctttctggtg gtatgcgtgg tatccgtggt gctgacttcc aatgcttcca acaagctcgt         840
gctgttggtc ttgctggtac tttccgtgct ggtggtggtg gtcgtggtga c                891

<210>  17
<211>  293
<212>  PRT
<213>  人工序列
<400>  17
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1              5                10               15      
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
          20               25               30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
      35               40                45              
His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50               55               60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65               70                75               80  
Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
              85               90               95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
          100              105               110         
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
      115             120              125             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
   130              135               140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145              150               155             160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
             165               170               175     
Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
           180              185              190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
       195              200               205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210              215              220                 
Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225              230              235              240 
Gly Gly Ser Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro 
              245              250              255     
Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe 
          260              265               270         
Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Gly Gly 
       275              280              285             
Gly Gly Arg Gly Asp 
290            

<210>  18
<211>  879
<212>  DNA
<213>  人工序列
<400>  18
gagcgcaaat gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca       60
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc         120
acgtgcgtgg tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg       180
gacggcgtgg aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg      240
ttccgtgtgg tcagcgtcct caccgtcgtg caccaggact ggctgaacgg caaggagtac        300
aagtgcaagg tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc        360
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc      420
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catctccgtg        480
gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc catgctggac      540
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag        600
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag         660
agcctctccc tgtctccggg taaaggcggc ggaggatctg gcggaggcgg ttctggtggt        720
ggtggctctt tccaacctgt tcttcacctt gttgctctta actctcctct ttctggtggt              780
atgcgtggta tccgtggtgc tgacttccaa tgcttccaac aagctcgtgc tgttggtctt            840
gctggtactt tccgtgctgg tggtggtggt cgtggtgac                             879

<210>  19
<211>  294
<212>  PRT
<213>  人工序列
<400>  19
Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
1             5                10               15      
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
          20               25               30          
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
       35              40                45              
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
   50                55               60                  
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
65               70               75                80  
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
              85               90               95      
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
          100               105              110         
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
      115            120               125             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
   130              135              140                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145              150               155             160 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
             165               170              175     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
          180               185              190         
Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
      195                200              205             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210             215               220                 
Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225              230              235               240 
Gly Gly Gly Ser Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser 
              245              250              255     
Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys 
          260              265              270         
Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Gly 
       275              280              285             
Gly Gly Gly Arg Gly Asp 
    290                 

<210>  20
<211>  882
<212>  DNA
<213>  人工序列
<400>  20
gccgagtcta agtacggccc tccttgccca ccttgccctg ctccagaagc tgctggcggc        60
ccttccgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatctc ccggaccccc        120
gaagtgacct gcgtggtggt ggatgtgtcc caggaagatc ccgaggtgca gttcaattgg       180
tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagttcaac     240
tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa       300
gagtacaagt gcaaggtgtc caacaagggc ctgccctcca gcatcgaaaa gaccatctcc       360
aaggccaagg gccagccccg ggaaccccag gtgtacacac tgcctccaag ccaggaagag    420
atgaccaaga accaggtgtc cctgacctgt ctcgtgaagg gcttctaccc ctccgatatc        480
gccgtggaat gggagtccaa cggccagcct gagaacaact acaagaccac cccccctgtg      540
ctggactccg acggctcctt cttcctgtac tcccgcctga ccgtggacaa gtccagatgg        600
caggaaggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc       660
cagaagtccc tgtccctgtc tctgggcggc ggcggaggat ctggcggagg cggttctggt      720
ggtggtggct ctttccaacc tgttcttcac cttgttgctc ttaactctcc tctttctggt            780
ggtatgcgtg gtatccgtgg tgctgacttc caatgcttcc aacaagctcg tgctgttggt         840
cttgctggta ctttccgtgc tggtggtggt ggtcgtggtg ac                         882

<210>  21
<211>  295
<212>  PRT
<213>  人工序列
<400>  21
Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys 
1              5                10                15      
Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His 
           20               25               30          
Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
      35                40               45              
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
   50               55                60                  
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65               70                75               80  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
              85               90                95      
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
          100              105              110         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
       115              120               125             
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
   130            135              140                 
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145              150              155               160 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
             165               170              175     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
          180              185               190         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
      195               200              205             
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
   210               215               220                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225              230               235              240 
Leu Ser Leu Gly Lys Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
             245               250              255     
Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
          260               265             270         

Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        275              280               285             
Gly Gly Gly Gly Arg Gly Asp 
        290               295 

<210>  22
<211>  885
<212>  DNA
<213>  人工序列
<400>  22
agaaatactg gcagaggcgg cgaggaaaag aagaaagaga aagaaaaaga ggaacaggaa   60
gagagagaga ctaagacccc cgagtgcccc tcccacacac agcctctggg cgtgttcctg      120
tttcccccaa agcccaagga caccctgatg atctcccgga cccccgaagt gacctgcgtg       180
gtggtggatg tgtcccagga agatcccgag gtgcagttca attggtacgt ggacggcgtg       240
gaagtgcaca acgccaagac caagccccgc gaggaacagt tcaactccac ctaccgggtg      300
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag       360
gtgtccaaca agggcctgcc ctccagcatc gaaaagacca tctccaaggc caagggccag      420
ccccgggaac cccaggtgta cacactgcct ccaagccagg aagaaatgac caagaaccag     480
gtgtccctga cctgtctcgt gaagggcttc tacccctccg atatcgccgt ggaatgggag        540
tccaacggcc agcctgagaa caactacaag accacccccc ctgtgctgga ctccgacggc      600
tccttcttcc tgtactcccg cctgaccgtg gacaagtcca gatggcagga aggcaacgtg        660
ttctcctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtcc        720
ctgtctctgg gcaagttcca acctgttctt caccttgttg ctcttaactc tcctctttct             780
ggtggtatgc gtggtatccg tggtgctgac ttccaatgct tccaacaagc tcgtgctgtt          840
ggtcttgctg gtactttccg tgctggtggt ggtggtcgtg gtgac                       885


<210>  23
<211>  345
<212>  PRT
<213>  人工序列
<400>  23
Arg Gly Asp Gly Gly Gly Gly Phe Gln Pro Val Leu His Leu Val Ala 
1              5                10                15      
Leu Asn Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp 
          20               25                30          
Phe Gln Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe 
       35                40               45              
Arg Ala Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu 
    50               55               60                  
Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln 
65                70               75               80  
Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Gly Gly Gly 
              85                90               95      
Gly Arg Gly Asp Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys 
          100               105               110  
Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu 
       115              120               125             
Cys Pro Ser His Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys 
   130              135              140                 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
145              150             155               160  
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
             165               170               175     
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
           180             185               190         
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
       195              200              205             
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
   210               215               220                 
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
225             230             235              240
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
             245               250              255    
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
          260               265              270         
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
      275              280               285             
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
   290              295               300                 
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
305              310              315               320
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
              325              330              335     
Lys Ser Leu Ser Leu Ser Leu Gly Lys 
          340              345
 <210>  24
<211>  1035
<212>  DNA
<213>  人工序列
<400>  24
cgtggtgacg gtggtggtgg tttccaacct gttcttcacc ttgttgctct taactctcct       60
ctttctggtg gtatgcgtgg tatccgtggt gctgacttcc aatgcttcca acaagctcgt      120
gctgttggtc ttgctggtac tttccgtgct ttccaacctg ttcttcacct tgttgctctt         180
aactctcctc tttctggtgg tatgcgtggt atccgtggtg ctgacttcca atgcttccaa       240
caagctcgtg ctgttggtct tgctggtact ttccgtgctg gtggtggtgg tcgtggtgac      300
agaaatactg gcagaggcgg cgaggaaaag aagaaagaga aagaaaaaga ggaacaggaa 360
gagagagaga ctaagacccc cgagtgcccc tcccacacac agcctctggg cgtgttcctg   420
tttcccccaa agcccaagga caccctgatg atctcccgga cccccgaagt gacctgcgtg    480
gtggtggatg tgtcccagga agatcccgag gtgcagttca attggtacgt ggacggcgtg     540
gaagtgcaca acgccaagac caagccccgc gaggaacagt tcaactccac ctaccgggtg    600
gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag     660
gtgtccaaca agggcctgcc ctccagcatc gaaaagacca tctccaaggc caagggccag    720
ccccgggaac cccaggtgta cacactgcct ccaagccagg aagaaatgac caagaaccag   780
gtgtccctga cctgtctcgt gaagggcttc tacccctccg atatcgccgt ggaatgggag      840
tccaacggcc agcctgagaa caactacaag accacccccc ctgtgctgga ctccgacggc    900
tccttcttcc tgtactcccg cctgaccgtg gacaagtcca gatggcagga aggcaacgtg      960
ttctcctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtcc      1020
ctgtctctgg gcaag                                              1035
