                         SEQUENCE LISTING

<110>  UNIVERSITY OF MALTA
 
<120>  BIOMARKERS PREDICTING SENSITIVITY TO PP2A ACTIVATION THERAPY IN CANCER

<130>  N408821WO

<150>  GB1704536.0
<151>  2017-03-22

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2605
<212>  DNA
<213>  Homo sapiens

<400>  1
cttaaacgcg actcaaggcg tcgggtttgt tgtcaaccaa tcacaaggca gcctcgctcg       60

agcgcaggcc aatcggcttt ctagctagag ggtttaactc ctatttaaaa agaagaacct      120

ttgaattcta acggctgagc tcttggaaga cttgggtcct tgggtcgcag gtgggagccg      180

acgggtgggt agaccgtggg ggatatctca gtggcggacg aggacggcgg ggacaagggg      240

cggctggtcg gagtggcgga gcgtcaagtc ccctgtcggt tcctccgtcc ctgagtgtcc      300

ttggcgctgc cttgtgcccg cccagcgcct ttgcatccgc tcctgggcac cgaggcgccc      360

tgtaggatac tgcttgttac ttattacagc tagagggtct cactccattg cccaggccag      420

agtgcgggga tatttgataa gaaacttcag tgaaggccgg gcgcggtggc tcatgcccgt      480

aatcccagca ttttcggagg ccgaggctgg agtgcaatgg tgtgatctca gctcactgca      540

acctctgctt cctgggttta agtgattctc ctgcctcagc ctcccgagta gctgggatta      600

caggcatcat ggaccgatct aaagaaaact gcatttcagg acctgttaag gctacagctc      660

cagttggagg tccaaaacgt gttctcgtga ctcagcaatt tccttgtcag aatccattac      720

ctgtaaatag tggccaggct cagcgggtct tgtgtccttc aaattcttcc cagcgcattc      780

ctttgcaagc acaaaagctt gtctccagtc acaagccggt tcagaatcag aagcagaagc      840

aattgcaggc aaccagtgta cctcatcctg tctccaggcc actgaataac acccaaaaga      900

gcaagcagcc cctgccatcg gcacctgaaa ataatcctga ggaggaactg gcatcaaaac      960

agaaaaatga agaatcaaaa aagaggcagt gggctttgga agactttgaa attggtcgcc     1020

ctctgggtaa aggaaagttt ggtaatgttt atttggcaag agaaaagcaa agcaagttta     1080

ttctggctct taaagtgtta tttaaagctc agctggagaa agccggagtg gagcatcagc     1140

tcagaagaga agtagaaata cagtcccacc ttcggcatcc taatattctt agactgtatg     1200

gttatttcca tgatgctacc agagtctacc taattctgga atatgcacca cttggaacag     1260

tttatagaga acttcagaaa ctttcaaagt ttgatgagca gagaactgct acttatataa     1320

cagaattggc aaatgccctg tcttactgtc attcgaagag agttattcat agagacatta     1380

agccagagaa cttacttctt ggatcagctg gagagcttaa aattgcagat tttgggtggt     1440

cagtacatgc tccatcttcc aggaggacca ctctctgtgg caccctggac tacctgcccc     1500

ctgaaatgat tgaaggtcgg atgcatgatg agaaggtgga tctctggagc cttggagttc     1560

tttgctatga atttttagtt gggaagcctc cttttgaggc aaacacatac caagagacct     1620

acaaaagaat atcacgggtt gaattcacat tccctgactt tgtaacagag ggagccaggg     1680

acctcatttc aagactgttg aagcataatc ccagccagag gccaatgctc agagaagtac     1740

ttgaacaccc ctggatcaca gcaaattcat caaaaccatc aaattgccaa aacaaagaat     1800

cagctagcaa acagtcttag gaatcgtgca gggggagaaa tccttgagcc agggctgcca     1860

tataacctga caggaacatg ctactgaagt ttattttacc attgactgct gccctcaatc     1920

tagaacgcta cacaagaaat atttgtttta ctcagcaggt gtgccttaac ctccctattc     1980

agaaagctcc acatcaataa acatgacact ctgaagtgaa agtagccacg agaattgtgc     2040

tacttatact ggttcataat ctggaggcaa ggttcgactg cagccgcccc gtcagcctgt     2100

gctaggcatg gtgtcttcac aggaggcaaa tccagagcct ggctgtgggg aaagtgacca     2160

ctctgccctg accccgatca gttaaggagc tgtgcaataa ccttcctagt acctgagtga     2220

gtgtgtaact tattgggttg gcgaagcctg gtaaagctgt tggaatgagt atgtgattct     2280

ttttaagtat gaaaataaag atatatgtac agacttgtat tttttctctg gtggcattcc     2340

tttaggaatg ctgtgtgtct gtccggcacc ccggtaggcc tgattgggtt tctagtcctc     2400

cttaaccact tatctcccat atgagagtgt gaaaaatagg aacacgtgct ctacctccat     2460

ttagggattt gcttgggata cagaagaggc catgtgtctc agagctgtta agggcttatt     2520

tttttaaaac attggagtca tagcatgtgt gtaaacttta aatatgcaaa taaataagta     2580

tctatgtcta aaaaaaaaaa aaaaa                                           2605


<210>  2
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  3
<211>  2896
<212>  DNA
<213>  Homo sapiens

<400>  3
acgcttgcgc gcgggattta aactgcggcg gtttacgcgg cgttaagact tcgtagggtt       60

agcgaaattg aggtttcttg gtattgcgcg tttctcttcc ttgctgactc tccgaatggc      120

catggactcg tcgcttcagg cccgcctgtt tcccggtctc gctatcaaga tccaacgcag      180

taatggttta attcacagtg ccaatgtaag gactgtgaac ttggagaaat cctgtgtttc      240

agtggaatgg gcagaaggag gtgccacaaa gggcaaagag attgattttg atgatgtggc      300

tgcaataaac ccagaactct tacagcttct tcccttacat ccgaaggaca atctgccctt      360

gcaggaaaat gtaacaatcc agaaacaaaa acggagatcc gtcaactcca aaattcctgc      420

tccaaaagaa agtcttcgaa gccgctccac tcgcatgtcc actgtctcag agcttcgcat      480

cacggctcag gagaatgaca tggaggtgga gctgcctgca gctgcaaact cccgcaagca      540

gttttcagtt cctcctgccc ccactaggcc ttcctgccct gcagtggctg aaataccatt      600

gaggatggtc agcgaggaga tggaagagca agtccattcc atccgaggca gctcttctgc      660

aaaccctgtg aactcagttc ggaggaaatc atgtcttgtg aaggaagtgg aaaaaatgaa      720

gaacaagcga gaagagaaga aggcccagaa ctctgaaatg agaatgaaga gagctcagga      780

gtatgacagt agttttccaa actgggaatt tgcccgaatg attaaagaat ttcgggctac      840

tttggaatgt catccactta ctatgactga tcctatcgaa gagcacagaa tatgtgtctg      900

tgttaggaaa cgcccactga ataagcaaga attggccaag aaagaaattg atgtgatttc      960

cattcctagc aagtgtctcc tcttggtaca tgaacccaag ttgaaagtgg acttaacaaa     1020

gtatctggag aaccaagcat tctgctttga ctttgcattt gatgaaacag cttcgaatga     1080

agttgtctac aggttcacag caaggccact ggtacagaca atctttgaag gtggaaaagc     1140

aacttgtttt gcatatggcc agacaggaag tggcaagaca catactatgg gcggagacct     1200

ctctgggaaa gcccagaatg catccaaagg gatctatgcc atggcctccc gggacgtctt     1260

cctcctgaag aatcaaccct gctaccggaa gttgggcctg gaagtctatg tgacattctt     1320

cgagatctac aatgggaagc tgtttgacct gctcaacaag aaggccaagc tgcgcgtgct     1380

ggaggacggc aagcaacagg tgcaagtggt ggggctgcag gagcatctgg ttaactctgc     1440

tgatgatgtc atcaagatga tcgacatggg cagcgcctgc agaacctctg ggcagacatt     1500

tgccaactcc aattcctccc gctcccacgc gtgcttccaa attattcttc gagctaaagg     1560

gagaatgcat ggcaagttct ctttggtaga tctggcaggg aatgagcgag gcgcggacac     1620

ttccagtgct gaccggcaga cccgcatgga gggcgcagaa atcaacaaga gtctcttagc     1680

cctgaaggag tgcatcaggg ccctgggaca gaacaaggct cacaccccgt tccgtgagag     1740

caagctgaca caggtgctga gggactcctt cattggggag aactctagga cttgcatgat     1800

tgccacgatc tcaccaggca taagctcctg tgaatatact ttaaacaccc tgagatatgc     1860

agacagggtc aaggagctga gcccccacag tgggcccagt ggagagcagt tgattcaaat     1920

ggaaacagaa gagatggaag cctgctctaa cggggcgctg attccaggca atttatccaa     1980

ggaagaggag gaactgtctt cccagatgtc cagctttaac gaagccatga ctcagatcag     2040

ggagctggag gagaaggcta tggaagagct caaggagatc atacagcaag gaccagactg     2100

gcttgagctc tctgagatga ccgagcagcc agactatgac ctggagacct ttgtgaacaa     2160

agcggaatct gctctggccc agcaagccaa gcatttctca gccctgcgag atgtcatcaa     2220

ggccttgcgc ctggccatgc agctggaaga gcaggctagc agacaaataa gcagcaagaa     2280

acggccccag tgacgactgc aaataaaaat ctgtttggtt tgacacccag cctcttccct     2340

ggccctcccc agagaacttt gggtacctgg tgggtctagg cagggtctga gctgggacag     2400

gttctggtaa atgccaagta tgggggcatc tgggcccagg gcagctgggg agggggtcag     2460

agtgacatgg gacactcctt ttctgttcct cagttgtcgc cctcacgaga ggaaggagct     2520

cttagttacc cttttgtgtt gcccttcttt ccatcaaggg gaatgttctc agcatagagc     2580

tttctccgca gcatcctgcc tgcgtggact ggctgctaat ggagagctcc ctggggttgt     2640

cctggctctg gggagagaga cggagccttt agtacagcta tctgctggct ctaaaccttc     2700

tacgcctttg ggccgagcac tgaatgtctt gtactttaaa aaaatgtttc tgagacctct     2760

ttctacttta ctgtctccct agagatccta gaggatccct actgttttct gttttatgtg     2820

tttatacatt gtatgtaaca ataaagagaa aaaataaatc agctgtttaa gtgtgtggaa     2880

aaaaaaaaaa aaaaaa                                                     2896


<210>  4
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Met Asp Ser Ser Leu Gln Ala Arg Leu Phe Pro Gly Leu Ala 
1               5                   10                  15      


Ile Lys Ile Gln Arg Ser Asn Gly Leu Ile His Ser Ala Asn Val Arg 
            20                  25                  30          


Thr Val Asn Leu Glu Lys Ser Cys Val Ser Val Glu Trp Ala Glu Gly 
        35                  40                  45              


Gly Ala Thr Lys Gly Lys Glu Ile Asp Phe Asp Asp Val Ala Ala Ile 
    50                  55                  60                  


Asn Pro Glu Leu Leu Gln Leu Leu Pro Leu His Pro Lys Asp Asn Leu 
65                  70                  75                  80  


Pro Leu Gln Glu Asn Val Thr Ile Gln Lys Gln Lys Arg Arg Ser Val 
                85                  90                  95      


Asn Ser Lys Ile Pro Ala Pro Lys Glu Ser Leu Arg Ser Arg Ser Thr 
            100                 105                 110         


Arg Met Ser Thr Val Ser Glu Leu Arg Ile Thr Ala Gln Glu Asn Asp 
        115                 120                 125             


Met Glu Val Glu Leu Pro Ala Ala Ala Asn Ser Arg Lys Gln Phe Ser 
    130                 135                 140                 


Val Pro Pro Ala Pro Thr Arg Pro Ser Cys Pro Ala Val Ala Glu Ile 
145                 150                 155                 160 


Pro Leu Arg Met Val Ser Glu Glu Met Glu Glu Gln Val His Ser Ile 
                165                 170                 175     


Arg Gly Ser Ser Ser Ala Asn Pro Val Asn Ser Val Arg Arg Lys Ser 
            180                 185                 190         


Cys Leu Val Lys Glu Val Glu Lys Met Lys Asn Lys Arg Glu Glu Lys 
        195                 200                 205             


Lys Ala Gln Asn Ser Glu Met Arg Met Lys Arg Ala Gln Glu Tyr Asp 
    210                 215                 220                 


Ser Ser Phe Pro Asn Trp Glu Phe Ala Arg Met Ile Lys Glu Phe Arg 
225                 230                 235                 240 


Ala Thr Leu Glu Cys His Pro Leu Thr Met Thr Asp Pro Ile Glu Glu 
                245                 250                 255     


His Arg Ile Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys Gln Glu 
            260                 265                 270         


Leu Ala Lys Lys Glu Ile Asp Val Ile Ser Ile Pro Ser Lys Cys Leu 
        275                 280                 285             


Leu Leu Val His Glu Pro Lys Leu Lys Val Asp Leu Thr Lys Tyr Leu 
    290                 295                 300                 


Glu Asn Gln Ala Phe Cys Phe Asp Phe Ala Phe Asp Glu Thr Ala Ser 
305                 310                 315                 320 


Asn Glu Val Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Gln Thr Ile 
                325                 330                 335     


Phe Glu Gly Gly Lys Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ser 
            340                 345                 350         


Gly Lys Thr His Thr Met Gly Gly Asp Leu Ser Gly Lys Ala Gln Asn 
        355                 360                 365             


Ala Ser Lys Gly Ile Tyr Ala Met Ala Ser Arg Asp Val Phe Leu Leu 
    370                 375                 380                 


Lys Asn Gln Pro Cys Tyr Arg Lys Leu Gly Leu Glu Val Tyr Val Thr 
385                 390                 395                 400 


Phe Phe Glu Ile Tyr Asn Gly Lys Leu Phe Asp Leu Leu Asn Lys Lys 
                405                 410                 415     


Ala Lys Leu Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln Val Val 
            420                 425                 430         


Gly Leu Gln Glu His Leu Val Asn Ser Ala Asp Asp Val Ile Lys Met 
        435                 440                 445             


Ile Asp Met Gly Ser Ala Cys Arg Thr Ser Gly Gln Thr Phe Ala Asn 
    450                 455                 460                 


Ser Asn Ser Ser Arg Ser His Ala Cys Phe Gln Ile Ile Leu Arg Ala 
465                 470                 475                 480 


Lys Gly Arg Met His Gly Lys Phe Ser Leu Val Asp Leu Ala Gly Asn 
                485                 490                 495     


Glu Arg Gly Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg Met Glu 
            500                 505                 510         


Gly Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys Ile Arg 
        515                 520                 525             


Ala Leu Gly Gln Asn Lys Ala His Thr Pro Phe Arg Glu Ser Lys Leu 
    530                 535                 540                 


Thr Gln Val Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg Thr Cys 
545                 550                 555                 560 


Met Ile Ala Thr Ile Ser Pro Gly Ile Ser Ser Cys Glu Tyr Thr Leu 
                565                 570                 575     


Asn Thr Leu Arg Tyr Ala Asp Arg Val Lys Glu Leu Ser Pro His Ser 
            580                 585                 590         


Gly Pro Ser Gly Glu Gln Leu Ile Gln Met Glu Thr Glu Glu Met Glu 
        595                 600                 605             


Ala Cys Ser Asn Gly Ala Leu Ile Pro Gly Asn Leu Ser Lys Glu Glu 
    610                 615                 620                 


Glu Glu Leu Ser Ser Gln Met Ser Ser Phe Asn Glu Ala Met Thr Gln 
625                 630                 635                 640 


Ile Arg Glu Leu Glu Glu Lys Ala Met Glu Glu Leu Lys Glu Ile Ile 
                645                 650                 655     


Gln Gln Gly Pro Asp Trp Leu Glu Leu Ser Glu Met Thr Glu Gln Pro 
            660                 665                 670         


Asp Tyr Asp Leu Glu Thr Phe Val Asn Lys Ala Glu Ser Ala Leu Ala 
        675                 680                 685             


Gln Gln Ala Lys His Phe Ser Ala Leu Arg Asp Val Ile Lys Ala Leu 
    690                 695                 700                 


Arg Leu Ala Met Gln Leu Glu Glu Gln Ala Ser Arg Gln Ile Ser Ser 
705                 710                 715                 720 


Lys Lys Arg Pro Gln 
                725 


