                         SEQUENCE LISTING

<110>  Ludwig-Maximilians-Universitt Mnchen
       Michalakis, Stylianos
       Biel, Martin
 
<120>  GENE THERAPY FOR THE TREATMENT OF CNGB1-LINKED RETINITIS 
       PIGMENTOSA

<130>  599916: SA9-205PC; US2017/010PC

<150>  US 62/474,409
<151>  2017-03-21

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  99
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(99)
<223>  human RHO promoter fragment

<400>  1
agaagccaat taggccctca gtttctgcag cggggattaa tatgattatg aacaccccca       60

atctcccaga tgctgattca gccaggagct taggagggg                              99


<210>  2
<211>  350
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(350)
<223>  human RHO promoter fragment

<400>  2
aaaccagaaa gtctctagct gtccagagga catagcacag aggcccatgg tccctatttc       60

aaacccaggc caccagactg agctgggacc ttgggacaga caagtcatgc agaagttagg      120

ggaccttctc ctcccttttc ctggatcctg agtacctctc ctccctgacc tcaggcttcc      180

tcctagtgtc accttggccc ctcttagaag ccaattaggc cctcagtttc tgcagcgggg      240

attaatatga ttatgaacac ccccaatctc ccagatgctg attcagccag gagcttagga      300

gggggaggtc actttataag ggtctggggg ggtcagaacc cagagtcatc                 350


<210>  3
<211>  1245
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1245)
<223>  human CNGB1 protein

<400>  3

Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Thr Pro 
1               5                   10                  15      


Arg Lys Thr Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          


Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Thr 
        35                  40                  45              


Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  


Ala Val Ala Asp Pro Ser Pro Gln Glu Thr Lys Glu Ala Ala Leu Thr 
65                  70                  75                  80  


Ser Thr Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      


Ser Pro Ser His Arg Val Leu Thr Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         


Val Ile Pro Gln Pro Val His Ser Ile Thr Glu Asp Pro Ala Gln Ile 
        115                 120                 125             


Leu Gly His Gly Ser Thr Gly Asp Thr Gly Cys Thr Asp Glu Pro Asn 
    130                 135                 140                 


Glu Ala Leu Glu Ala Gln Asp Thr Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     


Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Thr Ala Pro Pro Gly 
            180                 185                 190         


Arg Pro Gln Glu Met Gly Pro Lys Leu Gln Ala Arg Glu Thr Pro Ser 
        195                 200                 205             


Leu Pro Thr Pro Ile Pro Leu Gln Pro Lys Glu Glu Pro Lys Glu Ala 
    210                 215                 220                 


Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln Ala Gln Thr Ser Ser Leu 
225                 230                 235                 240 


Pro Pro Thr Arg Asp Pro Ala Arg Leu Val Ala Trp Val Leu His Arg 
                245                 250                 255     


Leu Glu Met Ala Leu Pro Gln Pro Val Leu His Gly Lys Ile Gly Glu 
            260                 265                 270         


Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp Val Gln Thr Ile Ser Ile 
        275                 280                 285             


Leu Pro Gly Gly Gln Val Glu Pro Asp Leu Val Leu Glu Glu Val Glu 
    290                 295                 300                 


Pro Pro Trp Glu Asp Ala His Gln Asp Val Ser Thr Ser Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Val Val Pro Ala Tyr Glu Glu Glu Asn Lys Ala Val Glu Lys 
                325                 330                 335     


Met Pro Arg Glu Leu Ser Arg Ile Glu Glu Glu Lys Glu Asp Glu Glu 
            340                 345                 350         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Thr Glu 
        355                 360                 365             


Val Leu Leu Asp Ser Cys Val Val Ser Gln Val Gly Val Gly Gln Ser 
    370                 375                 380                 


Glu Glu Asp Gly Thr Arg Pro Gln Ser Thr Ser Asp Gln Lys Leu Trp 
385                 390                 395                 400 


Glu Glu Val Gly Glu Glu Ala Lys Lys Glu Ala Glu Glu Lys Ala Lys 
                405                 410                 415     


Glu Glu Ala Glu Glu Val Ala Glu Glu Glu Ala Glu Lys Glu Pro Gln 
            420                 425                 430         


Asp Trp Ala Glu Thr Lys Glu Glu Pro Glu Ala Glu Ala Glu Ala Ala 
        435                 440                 445             


Ser Ser Gly Val Pro Ala Thr Lys Gln His Pro Glu Val Gln Val Glu 
    450                 455                 460                 


Asp Thr Asp Ala Asp Ser Cys Pro Leu Met Ala Glu Glu Asn Pro Pro 
465                 470                 475                 480 


Ser Thr Val Leu Pro Pro Pro Ser Pro Ala Lys Ser Asp Thr Leu Ile 
                485                 490                 495     


Val Pro Ser Ser Ala Ser Gly Thr His Arg Lys Lys Leu Pro Ser Glu 
            500                 505                 510         


Asp Asp Glu Ala Glu Glu Leu Lys Ala Leu Ser Pro Ala Glu Ser Pro 
        515                 520                 525             


Val Val Ala Trp Ser Asp Pro Thr Thr Pro Lys Asp Thr Asp Gly Gln 
    530                 535                 540                 


Asp Arg Ala Ala Ser Thr Ala Ser Thr Asn Ser Ala Ile Ile Asn Asp 
545                 550                 555                 560 


Arg Leu Gln Glu Leu Val Lys Leu Phe Lys Glu Arg Thr Glu Lys Val 
                565                 570                 575     


Lys Glu Lys Leu Ile Asp Pro Asp Val Thr Ser Asp Glu Glu Ser Pro 
            580                 585                 590         


Lys Pro Ser Pro Ala Lys Lys Ala Pro Glu Pro Ala Pro Asp Thr Lys 
        595                 600                 605             


Pro Ala Glu Ala Glu Pro Val Glu Glu Glu His Tyr Cys Asp Met Leu 
    610                 615                 620                 


Cys Cys Lys Phe Lys His Arg Pro Trp Lys Lys Tyr Gln Phe Pro Gln 
625                 630                 635                 640 


Ser Ile Asp Pro Leu Thr Asn Leu Met Tyr Val Leu Trp Leu Phe Phe 
                645                 650                 655     


Val Val Met Ala Trp Asn Trp Asn Cys Trp Leu Ile Pro Val Arg Trp 
            660                 665                 670         


Ala Phe Pro Tyr Gln Thr Pro Asp Asn Ile His His Trp Leu Leu Met 
        675                 680                 685             


Asp Tyr Leu Cys Asp Leu Ile Tyr Phe Leu Asp Ile Thr Val Phe Gln 
    690                 695                 700                 


Thr Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Thr Asp Lys Lys 
705                 710                 715                 720 


Asp Met Arg Asn Asn Tyr Leu Lys Ser Arg Arg Phe Lys Met Asp Leu 
                725                 730                 735     


Leu Ser Leu Leu Pro Leu Asp Phe Leu Tyr Leu Lys Val Gly Val Asn 
            740                 745                 750         


Pro Leu Leu Arg Leu Pro Arg Cys Leu Lys Tyr Met Ala Phe Phe Glu 
        755                 760                 765             


Phe Asn Ser Arg Leu Glu Ser Ile Leu Ser Lys Ala Tyr Val Tyr Arg 
    770                 775                 780                 


Val Ile Arg Thr Thr Ala Tyr Leu Leu Tyr Ser Leu His Leu Asn Ser 
785                 790                 795                 800 


Cys Leu Tyr Tyr Trp Ala Ser Ala Tyr Gln Gly Leu Gly Ser Thr His 
                805                 810                 815     


Trp Val Tyr Asp Gly Val Gly Asn Ser Tyr Ile Arg Cys Tyr Tyr Phe 
            820                 825                 830         


Ala Val Lys Thr Leu Ile Thr Ile Gly Gly Leu Pro Asp Pro Lys Thr 
        835                 840                 845             


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Tyr Phe Thr Gly Val Phe 
    850                 855                 860                 


Ala Phe Ser Val Met Ile Gly Gln Met Arg Asp Val Val Gly Ala Ala 
865                 870                 875                 880 


Thr Ala Gly Gln Thr Tyr Tyr Arg Ser Cys Met Asp Ser Thr Val Lys 
                885                 890                 895     


Tyr Met Asn Phe Tyr Lys Ile Pro Lys Ser Val Gln Asn Arg Val Lys 
            900                 905                 910         


Thr Trp Tyr Glu Tyr Thr Trp His Ser Gln Gly Met Leu Asp Glu Ser 
        915                 920                 925             


Glu Leu Met Val Gln Leu Pro Asp Lys Met Arg Leu Asp Leu Ala Ile 
    930                 935                 940                 


Asp Val Asn Tyr Asn Ile Val Ser Lys Val Ala Leu Phe Gln Gly Cys 
945                 950                 955                 960 


Asp Arg Gln Met Ile Phe Asp Met Leu Lys Arg Leu Arg Ser Val Val 
                965                 970                 975     


Tyr Leu Pro Asn Asp Tyr Val Cys Lys Lys Gly Glu Ile Gly Arg Glu 
            980                 985                 990         


Met Tyr Ile Ile Gln Ala Gly Gln  Val Gln Val Leu Gly  Gly Pro Asp 
        995                 1000                 1005             


Gly Lys  Ser Val Leu Val Thr  Leu Lys Ala Gly Ser  Val Phe Gly 
    1010                 1015                 1020             


Glu Ile  Ser Leu Leu Ala Val  Gly Gly Gly Asn Arg  Arg Thr Ala 
    1025                 1030                 1035             


Asn Val  Val Ala His Gly Phe  Thr Asn Leu Phe Ile  Leu Asp Lys 
    1040                 1045                 1050             


Lys Asp  Leu Asn Glu Ile Leu  Val His Tyr Pro Glu  Ser Gln Lys 
    1055                 1060                 1065             


Leu Leu  Arg Lys Lys Ala Arg  Arg Met Leu Arg Ser  Asn Asn Lys 
    1070                 1075                 1080             


Pro Lys  Glu Glu Lys Ser Val  Leu Ile Leu Pro Pro  Arg Ala Gly 
    1085                 1090                 1095             


Thr Pro  Lys Leu Phe Asn Ala  Ala Leu Ala Met Thr  Gly Lys Met 
    1100                 1105                 1110             


Gly Gly  Lys Gly Ala Lys Gly  Gly Lys Leu Ala His  Leu Arg Ala 
    1115                 1120                 1125             


Arg Leu  Lys Glu Leu Ala Ala  Leu Glu Ala Ala Ala  Lys Gln Gln 
    1130                 1135                 1140             


Glu Leu  Val Glu Gln Ala Lys  Ser Ser Gln Asp Val  Lys Gly Glu 
    1145                 1150                 1155             


Glu Gly  Ser Ala Ala Pro Asp  Gln His Thr His Pro  Lys Glu Ala 
    1160                 1165                 1170             


Ala Thr  Asp Pro Pro Ala Pro  Arg Thr Pro Pro Glu  Pro Pro Gly 
    1175                 1180                 1185             


Ser Pro  Pro Ser Ser Pro Pro  Pro Ala Ser Leu Gly  Arg Pro Glu 
    1190                 1195                 1200             


Gly Glu  Glu Glu Gly Pro Ala  Glu Pro Glu Glu His  Ser Val Arg 
    1205                 1210                 1215             


Ile Cys  Met Ser Pro Gly Pro  Glu Pro Gly Glu Gln  Ile Leu Ser 
    1220                 1225                 1230             


Val Lys  Met Pro Glu Glu Arg  Glu Glu Lys Ala Glu  
    1235                 1240                 1245 


<210>  4
<211>  227
<212>  DNA
<213>  Simian virus 40


<220>
<221>  misc_feature
<222>  (1)..(227)
<223>  SV40 polyadenylation signal

<400>  4
ggccgcagac atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg       60

aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag      120

ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga      180

ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggta                    227


<210>  5
<211>  130
<212>  DNA
<213>  adeno-associated virus 2


<220>
<221>  misc_feature
<223>  L-ITR

<400>  5
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  6
<211>  131
<212>  DNA
<213>  adeno-associated virus 2


<220>
<221>  misc_feature
<223>  R-ITR

<400>  6
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag c                                                           131


<210>  7
<211>  10243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGL2.0-hRHO194-hCNGB1a-SV40 vector molecule

<400>  7
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggaaga tcggaattcg cccttaagcc tctcctccct gacctcaggc ttcctcctag      240

tgtcaccttg gcccctctta gaagccaatt aggccctcag tttctgcagc ggggattaat      300

atgattatga acacccccaa tctcccagat gctgattcag ccaggagctt aggaggggga      360

ggtcacttta taagggtctg ggggggtcag aacccagagt catcactagt aacggccgcc      420

agtgtgctgg aattcgccct tctccaccgc catgttgggc tgggtccaga gggtgctgcc      480

tcagccccca gggacccctc ggaagaccaa gatgcaggag gaagaggaag tggaaccaga      540

gccagagatg gaggcggagg tggaaccaga accgaatcct gaggaggccg agacagagtc      600

cgagtccatg ccccccgaag agtcattcaa ggaggaggaa gtggctgtgg cagacccaag      660

ccctcaggag accaaggagg ctgcccttac ttccaccata tccctccggg cccagggcgc      720

tgagatttct gaaatgaata gtcccagcca cagggtactg acctggctca tgaagggtgt      780

agagaaggtg atcccgcagc ctgttcacag catcacggag gacccggctc agatcctggg      840

gcatggcagc actggggaca cagggtgcac agatgaaccc aatgaggccc ttgaggccca      900

agacactagg cctgggctgc ggctgcttct gtggctggag cagaatctgg aaagagtgct      960

tcctcagccc cccaaatcct ctgaggtctg gagagatgag cctgcagttg ctacagcgcc     1020

tccaggacgc ccccaggaaa tggggcccaa gctgcaggcc cgggagaccc cctccctgcc     1080

cacacccatc cccctgcagc ccaaggagga acccaaggag gcaccagctc cagagcccca     1140

gcccggctcc caggcccaga cctcctccct gccaccaacc agggaccctg ccaggctggt     1200

ggcatgggtc ctgcacaggc tggagatggc cttgccgcag ccagtgctac atgggaaaat     1260

aggggaacag gagcctgact cccctgggat atgtgatgtg cagaccatca gcatccttcc     1320

tggaggacaa gtggagcctg accttgtcct agaggaggtt gaaccgccct gggaggatgc     1380

ccaccaggat gtcagtacca gcccacaggg tacagaggtg gttccagctt atgaagaaga     1440

gaacaaagct gtggagaaga tgcccagaga gctgtcccgg attgaagagg agaaagaaga     1500

tgaggaggag gaagaggaag aggaggagga ggaggaagag gaggaggtga ctgaggtgct     1560

gctggatagc tgtgtggtgt cgcaggtggg cgtgggccag agtgaagaag acgggacccg     1620

gccccagagc acttcagatc agaagctgtg ggaggaagtt ggggaggagg ccaagaagga     1680

ggctgaagag aaggccaagg aggaggccga ggaggtggct gaagaggagg ctgaaaagga     1740

gccccaggac tgggcggaga ccaaggagga gcctgaggct gaggccgagg ctgccagttc     1800

aggagtgcct gccacgaaac agcacccaga agtgcaggtg gaagatactg atgctgatag     1860

ctgccccctc atggcagaag agaatccacc ctcaaccgtg ttgccgccac catctcctgc     1920

caaatcagac acccttatag tcccaagctc agcctcgggg acacacagga agaagctgcc     1980

ctctgaggat gatgaggctg aagagctcaa ggcgttgtca ccagcagagt ccccagtggt     2040

tgcctggtct gaccccacca ccccgaagga cactgatggc caggaccgtg cggcctccac     2100

ggccagcaca aatagcgcca tcatcaacga ccggctccag gagctggtga agctcttcaa     2160

ggagcggaca gagaaagtga aggagaaact cattgaccct gacgtcacct ctgatgagga     2220

gagccccaag ccctccccag ccaagaaagc cccagagcca gctccagaca caaagcccgc     2280

tgaagccgag ccagtggaag aggagcacta ttgcgacatg ctctgctgca agttcaaaca     2340

ccgcccctgg aagaagtacc agtttcccca gagcattgac ccgctgacca acctgatgta     2400

tgtcctatgg ctgttcttcg tggtgatggc ctggaattgg aactgttggc tgattcccgt     2460

gcgctgggcc ttcccctacc agaccccgga caacatccac cactggctgc tgatggatta     2520

cctatgcgac ctcatctact tcctggacat caccgtgttc cagacacgcc tgcagtttgt     2580

cagaggcggg gacatcatta cggacaaaaa ggacatgcga aataactacc tgaagtctcg     2640

ccgcttcaag atggacctgc tcagcctcct gcccttggat tttctctatt tgaaagtcgg     2700

tgtgaacccc ctcctccgcc tgccccgctg tttaaagtac atggccttct tcgagtttaa     2760

cagccgcctg gaatccatcc tcagcaaagc ctacgtgtac agggtcatca ggaccacagc     2820

ctaccttctc tacagcctgc atttgaattc ctgtctttat tactgggcat cggcctatca     2880

gggcctcggc tccactcact gggtttacga tggcgtggga aacagttata ttcgctgtta     2940

ctactttgct gtgaagaccc tcatcaccat cggggggctg cctgacccca agacactctt     3000

tgaaattgtc ttccagctgc tgaattattt cacgggcgtc tttgctttct ctgtgatgat     3060

cggacagatg agagatgtgg taggggccgc caccgcggga cagacctact accgcagctg     3120

catggacagc acggtgaagt acatgaattt ctacaagatc cccaagtccg tgcagaaccg     3180

cgtcaagacc tggtacgagt acacctggca ctcgcaaggc atgctggatg agtcagagct     3240

gatggtgcag cttccagaca agatgcggct ggacctcgcc atcgacgtga actacaacat     3300

cgttagcaaa gtcgcactct ttcagggctg tgaccggcag atgatctttg acatgctgaa     3360

gaggcttcgc tctgttgtct acctgcccaa cgactatgtg tgcaagaagg gggagatcgg     3420

ccgtgagatg tacatcatcc aggcagggca agtgcaggtc ttgggcggcc ctgatgggaa     3480

atctgtgctg gtgacgctga aagctggatc tgtgtttgga gaaataagct tgctggctgt     3540

tgggggcggg aaccggcgca cggccaacgt ggtggcgcac gggtttacca acctcttcat     3600

cctggataag aaggacctga atgagatttt ggtgcattat cctgagtctc agaagttact     3660

ccggaagaaa gccaggcgca tgctgagaag caacaataag cccaaggagg agaagagcgt     3720

gctgatcctt ccaccccggg cgggcacccc aaagctcttc aacgctgccc tcgctatgac     3780

aggaaagatg ggtggcaagg gggcaaaagg cggcaaactt gctcacctcc gggcccggct     3840

caaagaactg gccgcgctgg aggcggctgc aaagcagcaa gagttggtgg aacaggccaa     3900

gagctcgcaa gacgtcaagg gagaggaagg ctccgccgcc ccagaccagc acacgcaccc     3960

aaaggaggcc gccaccgacc cacccgcgcc ccggacgccc cccgagcccc cggggtctcc     4020

accgagctct ccaccgcctg cctcccttgg gaggccggag ggagaggagg aggggccggc     4080

cgagcccgaa gagcactcgg tgaggatctg catgagcccg ggcccggagc cgggagagca     4140

gatcctgtcg gtgaagatgc cggaggaaag ggaggagaag gcggagtaag gtggggtgag     4200

gcggatccat ggccgcagac atgataagat acattgatga gtttggacaa accacaacta     4260

gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa     4320

ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg     4380

ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtactc     4440

gagttaaggg cgaattcccg ataaggatct tcctagagca tggctacgta gataagtagc     4500

atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc     4560

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4620

cccgggcggc ctcagtgagc gagcgagcgc gcagctgggc ctcagtgagc gagcgagcgc     4680

gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc     4740

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     4800

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     4860

catgtcgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     4920

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     4980

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     5040

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     5100

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     5160

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     5220

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     5280

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     5340

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     5400

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     5460

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     5520

tcacgttaag ggattttggt catgactgtg gaatgtgtgt cagttaggcg acataggtga     5580

tctatgtaga agcctagtgg aacaggttag tttgagtagc tttagaatgt aaattctggg     5640

atcatagtgt agtaatctct aattaacggt gacggtttgt aagacaggtc ttcgcaaaat     5700

caagcggcag gtgatttcaa cagattcttg ctgatggttt aggcgtacaa tgccctgaag     5760

aataagtaag agaatagcac tcctcgtcgc ctagaattac ctaccggcgt ccaccatacc     5820

ttcgattatc gcgcccactc tcccattagt cggcacaggt ggatgtgttg cgatagcccg     5880

ctaagatatt ctaaggcgta acgcagatga atattctaca gagttgccat aggcgttgaa     5940

cgcttcacgg acgataggaa tgttgcgtat agagcgtgag tcatcgaagt ggtgtataca     6000

ctcgtactta acatctagcc cggctctatc agtacaccag tgccttgaat gacatactca     6060

tcattaaact ttctcaacag tcaaacgacc aagtgcattt ccaaggagtg cgaaggagat     6120

tcattctctc gccagcactg taataggcac taaaagagtg aagataagct agagtgccgt     6180

gctaagacgg tgtcggaaca aagcggtctt acggtcagtc gtatttcctg tcgagtcccg     6240

tccagttgag cgtatcactc ccagtgtact agcaagccga gaaggctgtg cttggagtca     6300

atcggatgta ggatggtctc cagacaccgg gccaccactc ttcacgccta gaagcataga     6360

acgtcgagca gacatcaaag tcttagtacc ggacgtgccg tttcactgcg aatattacct     6420

gaagctgtac cgttattgcg gagcaaagtg acagtgctgc tcttatcata tttgtattga     6480

cgacagccgc cttcgcggtt tcctcagact ctagatcgaa tacaggctta ttgtaggcag     6540

aggcacgccc ttgttagtgg ctgcggcaat atcttccgat ccccttgtct aaccatgaat     6600

caattctctc atttgaagac cctaatatgt catcattagt gtttcaaatg ccaccaaata     6660

ccgcctagaa atgtctatga tgtgtgtcca ctagaagttg attcacaaac gactgctaga     6720

atcgcgtgat agggcatctt gaagtttaca ttgttgtatc gcaaggtact ccgatcttaa     6780

tggatgcgaa gtggtacgga tgcaatcaag cgcgtgagag cggtacatta gagcgttcac     6840

ctacgctacg ctaacgggcg attctgataa gaatgcacat tgcgtcgatt cataagatgt     6900

ctcgaccgca tgcgcaactt gtgaagtgtc tactatccct aagcgcatat ctcgcacagt     6960

aaccgaatat gtcggcatct gatgttaccg ttgagttagt gttcagctca cggaacttat     7020

tgtatgagta gagatttgta agagctgtta gttagctcgc tcagctaata gttgcccaca     7080

caacgtcaaa ttagagaacg gtcgtaacat tatcggtggt tctctaacta ctatcagtac     7140

ccacgactcg actctgccgc agctaggtat cgcctgaaag ccagtcagcg ttaaggagtg     7200

ctctgaccag gacaacaggc gtagtgagag ttacttgttc gttgctcttc cgactcggac     7260

ctgagttcgc caacgaccca cttgaggtct gagccggtga agagaagtaa gcatctcgtt     7320

cgcagcttgc cagcactttc agaacatgac ccctatttgt ttatttttct aaatacattc     7380

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag     7440

gaagagtggc cgcctcggcc taggcttttg caaagatcga tcaagagaca ggatgaggat     7500

cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct tgggtggaga     7560

ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc gccgtgttcc     7620

ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga     7680

atgaactgca agacgaggca gcgcggctat cgtggctggc cacgacgggc gttccttgcg     7740

cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg ggcgaagtgc     7800

cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc atcatggctg     7860

atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac caccaagcga     7920

aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat caggatgatc     7980

tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc aaggcgagca     8040

tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg     8100

tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg gcggaccgct     8160

atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc gaatgggctg     8220

accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc gccttctatc     8280

gccttcttga cgagttcttc tgaggtacca tgatgcgtgc atggtagaat gactcttgat     8340

aacggacttc gactaggcaa tatcccttgt caacttgtcg aggagaaaag tattgactga     8400

agcgctcccg gcacaacggc caaagaagtc tcagcaatgt tcttatttcc gaatgacatg     8460

cgtctccttg cgggtaaatc gccgaccgca aaacttagga gccaggatac agataggtct     8520

aacttaggtt aagggagtaa atcctgggat cgttcagttg taaccatata cttacgctgg     8580

ggcttctccg gcggatgtta ctgtcaccaa ccacgagatt tgaagtaaac gcatgattga     8640

gcacatagcc gcgctatccg acaatctcca aattgataac ataccgttcc atgaaggcca     8700

gaattactta ccggcccttt ccatgcgtgc gccataccgc actctgcgct tatccgtccg     8760

aggggagagt gtgcgatcct ccgttaagat attctcacgt atgacgtagc tatgtattgt     8820

gcagaggtag cgaaggcgtt gaacacttca cagatggtgg ggattcgggc aaagggcgtg     8880

ataacttggg gactaacata ggcgtaaact acgatggcac caactcaatc gcagctcgtg     8940

cgccctgaat caacgtactc atctcaactg attctcggca atctacggag cgacttgatt     9000

atcaacacct gtctagcagt tctaatcttc tgccaacatc gtacatagcc tccaagagat     9060

tatcatacct atcggcacag aagtgacacg acgccgaagg gtagcggact tctggtcaac     9120

cacaattccc caggggacag gtcctgcggt gcgcatcact ttgtaagtgc aagcaaccca     9180

agtgagccca gcctggactg agctggttcc tgtgtcaggt cgaggctggg gatgacagct     9240

cttgtaaaca tagtgatcaa gcgtggcgtc gaacggtcga gaaactcata gtacctcggg     9300

tagcaactta ctcaggttat tgcttgaagc tgtactattt caggagcgct gaaggtctct     9360

tcttctgtag actgaactcg caagggtcgt gaagtcggtt ccttcaatgc ttaacaagaa     9420

caaaggctta ctgtgcagac tggaacgccc atctagcggc tcgcgtcttg aatgctcggt     9480

cccctttgtc attgcggata caatccattt ccctcattca ccagcttgcg aagtctacat     9540

tgagtagacg aatgcgacct agaagaggtg cgcttcagaa cttgtgagga gtggttgatg     9600

ctctatactc catttggtgt ttcgtgcatc accgcgatag gctgacaaga ggtcttgaac     9660

attgaatagc aaggcacttc cggtctcata gaagagagca cgggataagg tacgcgcgtg     9720

gtacgggagg atcaaggggc tacacgatag aaaggcttct ccctcactcg ctaggaggca     9780

aatgcagaac gctggttact actacgatac gtgaaacttg tccaacggtt gcccaaagtg     9840

ttaagtgtct atcaccctag tgccgtttcc cggagaaaac gccaggttga atccgcattt     9900

gaagctacga tggtgaagtc tgggtcgagc gcgccgcatg ttgattgcgt gagtaggctc     9960

gaccaagaac cgctagtagc gtcgctgtag aaatagttct cgacagaccg tcgagtttag    10020

aaaatggtag cagcattgtt cgcatctcaa tcaagtatgg attacggtgt ttacactgtc    10080

ctgcggctac ccatcgcctg aaatccagct cgtgtcaagc cattgcctct ccgggacgcc    10140

gcatgaagta actacatata ccttgcacgg gttgactgcg gtccgttcag actcgaccaa    10200

ggacacaatc cagcgatcgg tgcgggcctc ttcgctatta cgc                      10243


<210>  8
<211>  3738
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human CNGB1 gerne

<400>  8
atgttgggct gggtccagag ggtgctgcct cagcccccag ggacccctcg gaagaccaag       60

atgcaggagg aagaggaagt ggaaccagag ccagagatgg aggcggaggt ggaaccagaa      120

ccgaatcctg aggaggccga gacagagtcc gagtccatgc cccccgaaga gtcattcaag      180

gaggaggaag tggctgtggc agacccaagc cctcaggaga ccaaggaggc tgcccttact      240

tccaccatat ccctccgggc ccagggcgct gagatttctg aaatgaatag tcccagccac      300

agggtactga cctggctcat gaagggtgta gagaaggtga tcccgcagcc tgttcacagc      360

atcacggagg acccggctca gatcctgggg catggcagca ctggggacac agggtgcaca      420

gatgaaccca atgaggccct tgaggcccaa gacactaggc ctgggctgcg gctgcttctg      480

tggctggagc agaatctgga aagagtgctt cctcagcccc ccaaatcctc tgaggtctgg      540

agagatgagc ctgcagttgc tacagcgcct ccaggacgcc cccaggaaat ggggcccaag      600

ctgcaggccc gggagacccc ctccctgccc acacccatcc ccctgcagcc caaggaggaa      660

cccaaggagg caccagctcc agagccccag cccggctccc aggcccagac ctcctccctg      720

ccaccaacca gggaccctgc caggctggtg gcatgggtcc tgcacaggct ggagatggcc      780

ttgccgcagc cagtgctaca tgggaaaata ggggaacagg agcctgactc ccctgggata      840

tgtgatgtgc agaccatcag catccttcct ggaggacaag tggagcctga ccttgtccta      900

gaggaggttg aaccgccctg ggaggatgcc caccaggatg tcagtaccag cccacagggt      960

acagaggtgg ttccagctta tgaagaagag aacaaagctg tggagaagat gcccagagag     1020

ctgtcccgga ttgaagagga gaaagaagat gaggaggagg aagaggaaga ggaggaggag     1080

gaggaagagg aggaggtgac tgaggtgctg ctggatagct gtgtggtgtc gcaggtgggc     1140

gtgggccaga gtgaagaaga cgggacccgg ccccagagca cttcagatca gaagctgtgg     1200

gaggaagttg gggaggaggc caagaaggag gctgaagaga aggccaagga ggaggccgag     1260

gaggtggctg aagaggaggc tgaaaaggag ccccaggact gggcggagac caaggaggag     1320

cctgaggctg aggccgaggc tgccagttca ggagtgcctg ccacgaaaca gcacccagaa     1380

gtgcaggtgg aagatactga tgctgatagc tgccccctca tggcagaaga gaatccaccc     1440

tcaaccgtgt tgccgccacc atctcctgcc aaatcagaca cccttatagt cccaagctca     1500

gcctcgggga cacacaggaa gaagctgccc tctgaggatg atgaggctga agagctcaag     1560

gcgttgtcac cagcagagtc cccagtggtt gcctggtctg accccaccac cccgaaggac     1620

actgatggcc aggaccgtgc ggcctccacg gccagcacaa atagcgccat catcaacgac     1680

cggctccagg agctggtgaa gctcttcaag gagcggacag agaaagtgaa ggagaaactc     1740

attgaccctg acgtcacctc tgatgaggag agccccaagc cctccccagc caagaaagcc     1800

ccagagccag ctccagacac aaagcccgct gaagccgagc cagtggaaga ggagcactat     1860

tgcgacatgc tctgctgcaa gttcaaacac cgcccctgga agaagtacca gtttccccag     1920

agcattgacc cgctgaccaa cctgatgtat gtcctatggc tgttcttcgt ggtgatggcc     1980

tggaattgga actgttggct gattcccgtg cgctgggcct tcccctacca gaccccggac     2040

aacatccacc actggctgct gatggattac ctatgcgacc tcatctactt cctggacatc     2100

accgtgttcc agacacgcct gcagtttgtc agaggcgggg acatcattac ggacaaaaag     2160

gacatgcgaa ataactacct gaagtctcgc cgcttcaaga tggacctgct cagcctcctg     2220

cccttggatt ttctctattt gaaagtcggt gtgaaccccc tcctccgcct gccccgctgt     2280

ttaaagtaca tggccttctt cgagtttaac agccgcctgg aatccatcct cagcaaagcc     2340

tacgtgtaca gggtcatcag gaccacagcc taccttctct acagcctgca tttgaattcc     2400

tgtctttatt actgggcatc ggcctatcag ggcctcggct ccactcactg ggtttacgat     2460

ggcgtgggaa acagttatat tcgctgttac tactttgctg tgaagaccct catcaccatc     2520

ggggggctgc ctgaccccaa gacactcttt gaaattgtct tccagctgct gaattatttc     2580

acgggcgtct ttgctttctc tgtgatgatc ggacagatga gagatgtggt aggggccgcc     2640

accgcgggac agacctacta ccgcagctgc atggacagca cggtgaagta catgaatttc     2700

tacaagatcc ccaagtccgt gcagaaccgc gtcaagacct ggtacgagta cacctggcac     2760

tcgcaaggca tgctggatga gtcagagctg atggtgcagc ttccagacaa gatgcggctg     2820

gacctcgcca tcgacgtgaa ctacaacatc gttagcaaag tcgcactctt tcagggctgt     2880

gaccggcaga tgatctttga catgctgaag aggcttcgct ctgttgtcta cctgcccaac     2940

gactatgtgt gcaagaaggg ggagatcggc cgtgagatgt acatcatcca ggcagggcaa     3000

gtgcaggtct tgggcggccc tgatgggaaa tctgtgctgg tgacgctgaa agctggatct     3060

gtgtttggag aaataagctt gctggctgtt gggggcggga accggcgcac ggccaacgtg     3120

gtggcgcacg ggtttaccaa cctcttcatc ctggataaga aggacctgaa tgagattttg     3180

gtgcattatc ctgagtctca gaagttactc cggaagaaag ccaggcgcat gctgagaagc     3240

aacaataagc ccaaggagga gaagagcgtg ctgatccttc caccccgggc gggcacccca     3300

aagctcttca acgctgccct cgctatgaca ggaaagatgg gtggcaaggg ggcaaaaggc     3360

ggcaaacttg ctcacctccg ggcccggctc aaagaactgg ccgcgctgga ggcggctgca     3420

aagcagcaag agttggtgga acaggccaag agctcgcaag acgtcaaggg agaggaaggc     3480

tccgccgccc cagaccagca cacgcaccca aaggaggccg ccaccgaccc acccgcgccc     3540

cggacgcccc ccgagccccc ggggtctcca ccgagctctc caccgcctgc ctcccttggg     3600

aggccggagg gagaggagga ggggccggcc gagcccgaag agcactcggt gaggatctgc     3660

atgagcccgg gcccggagcc gggagagcag atcctgtcgg tgaagatgcc ggaggaaagg     3720

gaggagaagg cggagtaa                                                   3738


<210>  9
<211>  194
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(194)
<223>  human RHO promoter fragment

<400>  9
tctcctccct gacctcaggc ttcctcctag tgtcaccttg gcccctctta gaagccaatt       60

aggccctcag tttctgcagc ggggattaat atgattatga acacccccaa tctcccagat      120

gctgattcag ccaggagctt aggaggggga ggtcacttta taagggtctg ggggggtcag      180

aacccagagt catc                                                        194


<210>  10
<211>  1065
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1065)
<223>  Abca4  (ATP binding cassette subfamily A member 4)

<400>  10

Met Asp Val Val Leu His His Val Pro Glu Ala Lys Leu Val Glu Cys 
1               5                   10                  15      


Ile Gly Gln Glu Leu Ile Phe Leu Leu Pro Asn Lys Asn Phe Lys His 
            20                  25                  30          


Arg Ala Tyr Ala Ser Leu Phe Arg Glu Leu Glu Glu Thr Leu Ala Asp 
        35                  40                  45              


Leu Gly Leu Ser Ser Phe Gly Ile Ser Asp Thr Pro Leu Glu Glu Ile 
    50                  55                  60                  


Phe Leu Lys Val Thr Glu Asp Ser Asp Ser Gly Pro Leu Phe Ala Gly 
65                  70                  75                  80  


Gly Ala Gln Gln Lys Arg Glu Asn Val Asn Pro Arg His Pro Cys Leu 
                85                  90                  95      


Gly Pro Arg Glu Lys Ala Gly Gln Thr Pro Gln Asp Ser Asn Val Cys 
            100                 105                 110         


Ser Pro Gly Ala Pro Ala Ala His Pro Glu Gly Gln Pro Pro Pro Glu 
        115                 120                 125             


Pro Glu Cys Pro Gly Pro Gln Leu Asn Thr Gly Thr Gln Leu Val Leu 
    130                 135                 140                 


Gln His Val Gln Ala Leu Leu Val Lys Arg Phe Gln His Thr Ile Arg 
145                 150                 155                 160 


Ser His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val 
                165                 170                 175     


Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr 
            180                 185                 190         


Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe 
        195                 200                 205             


Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp 
    210                 215                 220                 


Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly 
225                 230                 235                 240 


Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro 
                245                 250                 255     


Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr 
            260                 265                 270         


Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu 
        275                 280                 285             


Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro 
    290                 295                 300                 


Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg 
305                 310                 315                 320 


Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser 
                325                 330                 335     


Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile 
            340                 345                 350         


Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu 
        355                 360                 365             


Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly 
    370                 375                 380                 


Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His 
385                 390                 395                 400 


Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp 
                405                 410                 415     


His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg 
            420                 425                 430         


Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val 
        435                 440                 445             


Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr 
    450                 455                 460                 


Val Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe 
465                 470                 475                 480 


Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu 
                485                 490                 495     


Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro 
            500                 505                 510         


Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser 
        515                 520                 525             


Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys 
    530                 535                 540                 


Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu 
545                 550                 555                 560 


Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu 
                565                 570                 575     


Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu 
            580                 585                 590         


Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe 
        595                 600                 605             


Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu 
    610                 615                 620                 


Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu 
625                 630                 635                 640 


Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu 
                645                 650                 655     


His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe 
            660                 665                 670         


Ala Met Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val 
        675                 680                 685             


Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu 
    690                 695                 700                 


Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile 
705                 710                 715                 720 


Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr 
                725                 730                 735     


Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val 
            740                 745                 750         


Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Ser Gly Ala 
        755                 760                 765             


Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr 
    770                 775                 780                 


Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser 
785                 790                 795                 800 


Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp 
                805                 810                 815     


Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg 
            820                 825                 830         


Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys 
        835                 840                 845             


Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser 
    850                 855                 860                 


Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys 
865                 870                 875                 880 


Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln 
                885                 890                 895     


Ala Arg Arg Met Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly 
            900                 905                 910         


Arg Ala Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu 
        915                 920                 925             


Cys Thr Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly 
    930                 935                 940                 


Thr Ile Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr 
945                 950                 955                 960 


Met Lys Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro 
                965                 970                 975     


Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu 
            980                 985                 990         


Arg His Tyr Asn Met Leu Gln Phe  Gln Val Ser Ser Ser  Ser Leu Ala 
        995                 1000                 1005             


Arg Ile  Phe Gln Leu Leu Leu  Ser His Lys Asp Ser  Leu Leu Ile 
    1010                 1015                 1020             


Glu Glu  Tyr Ser Val Thr Gln  Thr Thr Leu Asp Gln  Val Phe Val 
    1025                 1030                 1035             


Asn Phe  Ala Lys Gln Gln Thr  Glu Ser His Asp Leu  Pro Leu His 
    1040                 1045                 1050             


Pro Arg  Ala Ala Gly Ala Ser  Arg Gln Ala Gln Asp  
    1055                 1060                 1065 


<210>  11
<211>  384
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(384)
<223>  AIPL1 (Aryl-hydrocarbon-interacting protein-like 1)

<400>  11

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


Val Ile Phe His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val 
        35                  40                  45              


Ile Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly 
    50                  55                  60                  


Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg 
65                  70                  75                  80  


Val His Glu Val Ala Glu Phe Trp Cys Asp Thr Ile His Thr Gly Val 
                85                  90                  95      


Tyr Pro Ile Leu Ser Arg Ser Leu Arg Gln Met Ala Gln Gly Lys Asp 
            100                 105                 110         


Pro Thr Glu Trp His Val His Thr Cys Gly Leu Ala Asn Met Phe Ala 
        115                 120                 125             


Tyr His Thr Leu Gly Tyr Glu Asp Leu Asp Glu Leu Gln Lys Glu Pro 
    130                 135                 140                 


Gln Pro Leu Val Phe Val Ile Glu Leu Leu Gln Val Asp Ala Pro Ser 
145                 150                 155                 160 


Asp Tyr Gln Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met Lys 
                165                 170                 175     


Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu Gly 
            180                 185                 190         


Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys Leu 
        195                 200                 205             


Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val Gln Trp Leu Lys 
    210                 215                 220                 


Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr Cys Gln Cys Leu 
225                 230                 235                 240 


Leu Lys Lys Glu Glu Tyr Tyr Glu Val Leu Glu His Thr Ser Asp Ile 
                245                 250                 255     


Leu Arg His His Pro Gly Ile Val Lys Ala Tyr Tyr Val Arg Ala Arg 
            260                 265                 270         


Ala His Ala Glu Val Trp Asn Glu Ala Glu Ala Lys Ala Asp Leu Gln 
        275                 280                 285             


Lys Val Leu Glu Leu Glu Pro Ser Met Gln Lys Ala Val Arg Arg Glu 
    290                 295                 300                 


Leu Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln Glu Glu Glu Arg 
305                 310                 315                 320 


Leu Arg Cys Arg Asn Met Leu Ser Gln Gly Ala Thr Gln Pro Pro Ala 
                325                 330                 335     


Glu Pro Pro Thr Glu Pro Pro Ala Gln Ser Ser Thr Glu Pro Pro Ala 
            340                 345                 350         


Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser Ala Gly Pro Pro Ala 
        355                 360                 365             


Glu Pro Ala Thr Glu Pro Pro Pro Ser Pro Gly His Ser Leu Gln His 
    370                 375                 380                 


<210>  12
<211>  585
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(585)
<223>  BEST1 (Bestrophin-1), isoform 1

<400>  12

Met Thr Ile Thr Tyr Thr Ser Gln Val Ala Asn Ala Arg Leu Gly Ser 
1               5                   10                  15      


Phe Ser Arg Leu Leu Leu Cys Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Tyr Gly Glu Phe Leu Ile Phe Leu Leu Cys Tyr Tyr Ile Ile Arg Phe 
        35                  40                  45              


Ile Tyr Arg Leu Ala Leu Thr Glu Glu Gln Gln Leu Met Phe Glu Lys 
    50                  55                  60                  


Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile Pro Ile Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg Trp Trp Asn Gln 
                85                  90                  95      


Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser Leu Val Ser Gly 
            100                 105                 110         


Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu Arg Arg Thr Leu 
        115                 120                 125             


Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His Leu Val Gln Ala 
145                 150                 155                 160 


Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu Lys Leu Ser Leu 
                165                 170                 175     


Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe Ala Asn Leu Ser 
            180                 185                 190         


Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro Ile Leu Leu Gln 
        195                 200                 205             


Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln Cys Gly His Leu 
    210                 215                 220                 


Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu Val Gly Arg Gln 
                245                 250                 255     


Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu Leu Asp Leu Val 
            260                 265                 270         


Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr Val Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln Val Ser Leu Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met Glu Pro Asp Met 
                325                 330                 335     


Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr Ala Ala Ser Ala 
            340                 345                 350         


Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe Asn Ile Ser Leu 
        355                 360                 365             


Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu Asp Glu Glu Asp 
    370                 375                 380                 


Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu Gln Ser His Asp 
385                 390                 395                 400 


His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu Leu Trp Pro Lys 
                405                 410                 415     


Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn His Lys Ala Ala 
            420                 425                 430         


Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala Trp Lys Leu Lys 
        435                 440                 445             


Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln Arg Pro Gly Tyr 
    450                 455                 460                 


Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro Met Phe Phe Pro 
465                 470                 475                 480 


Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val Thr Gly Ile Asp 
                485                 490                 495     


Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly Ala Lys Lys Ser 
            500                 505                 510         


Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met Glu His Pro Glu 
        515                 520                 525             


Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn Leu Thr Asp Met 
    530                 535                 540                 


Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu Glu Gln Ser Pro 
545                 550                 555                 560 


Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp Pro Tyr Trp Ala 
                565                 570                 575     


Leu Glu Asn Arg Asp Glu Ala His Ser 
            580                 585 


<210>  13
<211>  1977
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1977)
<223>  CACNA1F  (Voltage-dependent L-type calcium channel subunit 
       alpha-1F), isoform 1

<400>  13

Met Ser Glu Ser Glu Gly Gly Lys Asp Thr Thr Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Ala Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Ala Val Glu Gly Glu Ser Ser Gly Ala Ser Gly Leu Gly Thr Pro 
        35                  40                  45              


Lys Arg Arg Asn Gln His Ser Lys His Lys Thr Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Thr Leu Ala Asn Pro 
65                  70                  75                  80  


Leu Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Thr Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Thr Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ala Cys Thr Leu Asn Gln Thr Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Thr Val Phe Gln Cys Val Thr Met Glu Gly Trp Thr Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Glu Leu Asp Met 
                405                 410                 415     


Glu Asp Pro Ser Ala Asp Asp Asn Leu Gly Ser Met Ala Glu Glu Gly 
            420                 425                 430         


Arg Ala Gly His Arg Pro Gln Leu Ala Glu Leu Thr Asn Arg Arg Arg 
        435                 440                 445             


Gly Arg Leu Arg Trp Phe Ser His Ser Thr Arg Ser Thr His Ser Thr 
    450                 455                 460                 


Ser Ser His Ala Ser Leu Pro Ala Ser Asp Thr Gly Ser Met Thr Glu 
465                 470                 475                 480 


Thr Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala Leu Ala Ser Cys Thr 
                485                 490                 495     


Arg Cys Leu Asn Lys Ile Met Lys Thr Arg Val Cys Arg Arg Leu Arg 
            500                 505                 510         


Arg Ala Asn Arg Val Leu Arg Ala Arg Cys Arg Arg Ala Val Lys Ser 
        515                 520                 525             


Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val Phe Leu Asn Thr Leu 
    530                 535                 540                 


Thr Ile Ala Ser Glu His His Gly Gln Pro Val Trp Leu Thr Gln Ile 
545                 550                 555                 560 


Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu Phe Thr Val Glu Met 
                565                 570                 575     


Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala Tyr Val Ser Ser Phe 
            580                 585                 590         


Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr 
        595                 600                 605             


Thr Leu Val Glu Val Gly Ala Met Gln Pro Leu Gly Ile Ser Val Leu 
    610                 615                 620                 


Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Ala 
625                 630                 635                 640 


Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile 
                645                 650                 655     


Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu 
            660                 665                 670         


Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Gln Thr His 
        675                 680                 685             


Thr Lys Arg Ser Thr Phe Asp Thr Phe Pro Gln Ala Leu Leu Thr Val 
    690                 695                 700                 


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Val Val Met Tyr Asp Gly 
705                 710                 715                 720 


Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly Met Leu Val Cys Ile 
                725                 730                 735     


Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val 
            740                 745                 750         


Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser Gly Asp Ala Gly Thr 
        755                 760                 765             


Ala Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu Lys Asp Leu Pro Gln 
    770                 775                 780                 


Glu Asn Glu Gly Leu Val Pro Gly Val Glu Lys Glu Glu Glu Glu Gly 
785                 790                 795                 800 


Ala Arg Arg Glu Gly Ala Asp Met Glu Glu Glu Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Gly Val Glu Leu 
            820                 825                 830         


Leu Gln Glu Val Val Pro Lys Glu Lys Val Val Pro Ile Pro Glu Gly 
        835                 840                 845             


Ser Ala Phe Phe Cys Leu Ser Gln Thr Asn Pro Leu Arg Lys Gly Cys 
    850                 855                 860                 


His Thr Leu Ile His His His Val Phe Thr Asn Leu Ile Leu Val Phe 
865                 870                 875                 880 


Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu Asp Pro Ile Arg Ala 
                885                 890                 895     


His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr 
            900                 905                 910         


Ser Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Val Phe Gly Ala 
        915                 920                 925             


Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp Phe Asn Met Leu Asp 
    930                 935                 940                 


Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile His Ser Ser 
945                 950                 955                 960 


Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro 
                965                 970                 975     


Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys 
            980                 985                 990         


Val Phe Val Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
        995                 1000                 1005             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1010                 1015                 1020             


Gly Lys  Phe Tyr Thr Cys Thr  Asp Glu Ala Lys His  Thr Pro Gln 
    1025                 1030                 1035             


Glu Cys  Lys Gly Ser Phe Leu  Val Tyr Pro Asp Gly  Asp Val Ser 
    1040                 1045                 1050             


Arg Pro  Leu Val Arg Glu Arg  Leu Trp Val Asn Ser  Asp Phe Asn 
    1055                 1060                 1065             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1070                 1075                 1080             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ala 
    1085                 1090                 1095             


Tyr Ala  Glu Asp His Gly Pro  Ile Tyr Asn Tyr Arg  Val Glu Ile 
    1100                 1105                 1110             


Ser Val  Phe Phe Ile Val Tyr  Ile Ile Ile Ile Ala  Phe Phe Met 
    1115                 1120                 1125             


Met Asn  Ile Phe Val Gly Phe  Val Ile Ile Thr Phe  Arg Ala Gln 
    1130                 1135                 1140             


Gly Glu  Gln Glu Tyr Gln Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1145                 1150                 1155             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Gln Pro Leu  Arg Arg Tyr 
    1160                 1165                 1170             


Ile Pro  Lys Asn Pro His Gln  Tyr Arg Val Trp Ala  Thr Val Asn 
    1175                 1180                 1185             


Ser Ala  Ala Phe Glu Tyr Leu  Met Phe Leu Leu Ile  Leu Leu Asn 
    1190                 1195                 1200             


Thr Val  Ala Leu Ala Met Gln  His Tyr Glu Gln Thr  Ala Pro Phe 
    1205                 1210                 1215             


Asn Tyr  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Leu Phe 
    1220                 1225                 1230             


Thr Ile  Glu Met Val Leu Lys  Ile Ile Ala Phe Lys  Pro Lys His 
    1235                 1240                 1245             


Tyr Phe  Thr Asp Ala Trp Asn  Thr Phe Asp Ala Leu  Ile Val Val 
    1250                 1255                 1260             


Gly Ser  Ile Val Asp Ile Ala  Val Thr Glu Val Asn  Asn Gly Gly 
    1265                 1270                 1275             


His Leu  Gly Glu Ser Ser Glu  Asp Ser Ser Arg Ile  Ser Ile Thr 
    1280                 1285                 1290             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Ser 
    1295                 1300                 1305             


Lys Gly  Glu Gly Ile Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1310                 1315                 1320             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Ala  Met Ile Phe 
    1325                 1330                 1335             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Val Ala 
    1340                 1345                 1350             


Leu Gln  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1355                 1360                 1365             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1370                 1375                 1380             


Ala Trp  Gln Glu Ile Met Leu  Ala Ser Leu Pro Gly  Asn Arg Cys 
    1385                 1390                 1395             


Asp Pro  Glu Ser Asp Phe Gly  Pro Gly Glu Glu Phe  Thr Cys Gly 
    1400                 1405                 1410             


Ser Asn  Phe Ala Ile Ala Tyr  Phe Ile Ser Phe Phe  Met Leu Cys 
    1415                 1420                 1425             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1430                 1435                 1440             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1445                 1450                 1455             


Leu Asp  Glu Phe Lys Arg Ile  Trp Ser Glu Tyr Asp  Pro Gly Ala 
    1460                 1465                 1470             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Ala Leu  Leu Arg Arg 
    1475                 1480                 1485             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu Cys Pro  His Arg Val 
    1490                 1495                 1500             


Ala Cys  Lys Arg Leu Val Ala  Met Asn Met Pro Leu  Asn Ser Asp 
    1505                 1510                 1515             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1520                 1525                 1530             


Ser Leu  Lys Ile Lys Thr Glu  Gly Asn Leu Glu Gln  Ala Asn Gln 
    1535                 1540                 1545             


Glu Leu  Arg Ile Val Ile Lys  Lys Ile Trp Lys Arg  Met Lys Gln 
    1550                 1555                 1560             


Lys Leu  Leu Asp Glu Val Ile  Pro Pro Pro Asp Glu  Glu Glu Val 
    1565                 1570                 1575             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Asp Tyr Phe 
    1580                 1585                 1590             


Arg Lys  Phe Arg Arg Arg Lys  Glu Lys Gly Leu Leu  Gly Asn Asp 
    1595                 1600                 1605             


Ala Ala  Pro Ser Thr Ser Ser  Ala Leu Gln Ala Gly  Leu Arg Ser 
    1610                 1615                 1620             


Leu Gln  Asp Leu Gly Pro Glu  Met Arg Gln Ala Leu  Thr Cys Asp 
    1625                 1630                 1635             


Thr Glu  Glu Glu Glu Glu Glu  Gly Gln Glu Gly Val  Glu Glu Glu 
    1640                 1645                 1650             


Asp Glu  Lys Asp Leu Glu Thr  Asn Lys Ala Thr Met  Val Ser Gln 
    1655                 1660                 1665             


Pro Ser  Ala Arg Arg Gly Ser  Gly Ile Ser Val Ser  Leu Pro Val 
    1670                 1675                 1680             


Gly Asp  Arg Leu Pro Asp Ser  Leu Ser Phe Gly Pro  Ser Asp Asp 
    1685                 1690                 1695             


Asp Arg  Gly Thr Pro Thr Ser  Ser Gln Pro Ser Val  Pro Gln Ala 
    1700                 1705                 1710             


Gly Ser  Asn Thr His Arg Arg  Gly Ser Gly Ala Leu  Ile Phe Thr 
    1715                 1720                 1725             


Ile Pro  Glu Glu Gly Asn Ser  Gln Pro Lys Gly Thr  Lys Gly Gln 
    1730                 1735                 1740             


Asn Lys  Gln Asp Glu Asp Glu  Glu Val Pro Asp Arg  Leu Ser Tyr 
    1745                 1750                 1755             


Leu Asp  Glu Gln Ala Gly Thr  Pro Pro Cys Ser Val  Leu Leu Pro 
    1760                 1765                 1770             


Pro His  Arg Ala Gln Arg Tyr  Met Asp Gly His Leu  Val Pro Arg 
    1775                 1780                 1785             


Arg Arg  Leu Leu Pro Pro Thr  Pro Ala Gly Arg Lys  Pro Ser Phe 
    1790                 1795                 1800             


Thr Ile  Gln Cys Leu Gln Arg  Gln Gly Ser Cys Glu  Asp Leu Pro 
    1805                 1810                 1815             


Ile Pro  Gly Thr Tyr His Arg  Gly Arg Asn Ser Gly  Pro Asn Arg 
    1820                 1825                 1830             


Ala Gln  Gly Ser Trp Ala Thr  Pro Pro Gln Arg Gly  Arg Leu Leu 
    1835                 1840                 1845             


Tyr Ala  Pro Leu Leu Leu Val  Glu Glu Gly Ala Ala  Gly Glu Gly 
    1850                 1855                 1860             


Tyr Leu  Gly Arg Ser Ser Gly  Pro Leu Arg Thr Phe  Thr Cys Leu 
    1865                 1870                 1875             


His Val  Pro Gly Thr His Ser  Asp Pro Ser His Gly  Lys Arg Gly 
    1880                 1885                 1890             


Ser Ala  Asp Ser Leu Val Glu  Ala Val Leu Ile Ser  Glu Gly Leu 
    1895                 1900                 1905             


Gly Leu  Phe Ala Arg Asp Pro  Arg Phe Val Ala Leu  Ala Lys Gln 
    1910                 1915                 1920             


Glu Ile  Ala Asp Ala Cys Arg  Leu Thr Leu Asp Glu  Met Asp Asn 
    1925                 1930                 1935             


Ala Ala  Ser Asp Leu Leu Ala  Gln Gly Thr Ser Ser  Leu Tyr Ser 
    1940                 1945                 1950             


Asp Glu  Glu Ser Ile Leu Ser  Arg Phe Asp Glu Glu  Asp Leu Gly 
    1955                 1960                 1965             


Asp Glu  Met Ala Cys Val His  Ala Leu 
    1970                 1975         


<210>  14
<211>  438
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(438)
<223>  CLN3 (Battenin), isoform 1

<400>  14

Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Thr Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Thr Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Thr 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Thr Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Thr Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Thr Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Thr Phe Leu Ser Leu Thr Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Thr Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Thr Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Thr Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Thr Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Thr 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Thr Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
        275                 280                 285             


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu 
    290                 295                 300                 


Leu Leu Phe Phe Trp Asn Thr Ser Leu Ser His Ala Gln Gln Tyr Arg 
305                 310                 315                 320 


Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser 
                325                 330                 335     


Leu Arg Cys Cys Arg Ile Arg Phe Thr Trp Ala Leu Ala Leu Leu Gln 
            340                 345                 350         


Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu 
        355                 360                 365             


Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu 
    370                 375                 380                 


Gly Gly Ala Ala Tyr Val Asn Thr Phe His Asn Ile Ala Leu Glu Thr 
385                 390                 395                 400 


Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Thr Cys Ile Ser Asp 
                405                 410                 415     


Thr Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp 
            420                 425                 430         


Phe Leu Cys Gln Leu Ser 
        435             


<210>  15
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(232)
<223>  CLRN1 (Clarin-1)

<400>  15

Met Pro Ser Gln Gln Lys Lys Ile Ile Phe Cys Met Ala Gly Val Phe 
1               5                   10                  15      


Ser Phe Ala Cys Ala Leu Gly Val Val Thr Ala Leu Gly Thr Pro Leu 
            20                  25                  30          


Trp Ile Lys Ala Thr Val Leu Cys Lys Thr Gly Ala Leu Leu Val Asn 
        35                  40                  45              


Ala Ser Gly Gln Glu Leu Asp Lys Phe Met Gly Glu Met Gln Tyr Gly 
    50                  55                  60                  


Leu Phe His Gly Glu Gly Val Arg Gln Cys Gly Leu Gly Ala Arg Pro 
65                  70                  75                  80  


Phe Arg Phe Ser Phe Phe Pro Asp Leu Leu Lys Ala Ile Pro Val Ser 
                85                  90                  95      


Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu Ile Val Leu Thr 
            100                 105                 110         


Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe Gly Lys Pro Phe 
        115                 120                 125             


Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu Ser Phe Ile Ser 
    130                 135                 140                 


Gly Ser Cys Gly Cys Leu Val Met Ile Leu Phe Ala Ser Glu Val Lys 
145                 150                 155                 160 


Ile His His Leu Ser Glu Lys Ile Ala Asn Tyr Lys Glu Gly Thr Tyr 
                165                 170                 175     


Val Tyr Lys Thr Gln Ser Glu Lys Tyr Thr Thr Ser Phe Trp Val Ile 
            180                 185                 190         


Phe Phe Cys Phe Phe Val His Phe Leu Asn Gly Leu Leu Ile Arg Leu 
        195                 200                 205             


Ala Gly Phe Gln Phe Pro Phe Ala Lys Ser Lys Asp Ala Glu Thr Thr 
    210                 215                 220                 


Asn Val Ala Ala Asp Leu Met Tyr 
225                 230         


<210>  16
<211>  690
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(690)
<223>  CNGA1 (cGMP-gated cation channel alpha-1), isoform 1

<400>  16

Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn Thr Gln Gln Ser Phe 
1               5                   10                  15      


Val Thr Met Pro Asn Val Ile Val Pro Asp Ile Glu Lys Glu Ile Arg 
            20                  25                  30          


Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser Glu Asp Asp Asp Ser 
        35                  40                  45              


Ala Ser Thr Ser Glu Glu Ser Glu Asn Glu Asn Pro His Ala Arg Gly 
    50                  55                  60                  


Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly Pro Ser Gln Arg Glu 
65                  70                  75                  80  


Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn Val Asn Asn Ser Ser 
                85                  90                  95      


Asn Lys Asp Gln Glu Pro Glu Glu Lys Lys Lys Lys Lys Lys Glu Lys 
            100                 105                 110         


Lys Ser Lys Ser Asp Asp Lys Asn Glu Asn Lys Asn Asp Pro Glu Lys 
        115                 120                 125             


Lys Lys Lys Lys Lys Asp Lys Glu Lys Lys Lys Lys Glu Glu Lys Ser 
    130                 135                 140                 


Lys Asp Lys Lys Glu Glu Glu Lys Lys Glu Val Val Val Ile Asp Pro 
145                 150                 155                 160 


Ser Gly Asn Thr Tyr Tyr Asn Trp Leu Phe Cys Ile Thr Leu Pro Val 
                165                 170                 175     


Met Tyr Asn Trp Thr Met Val Ile Ala Arg Ala Cys Phe Asp Glu Leu 
            180                 185                 190         


Gln Ser Asp Tyr Leu Glu Tyr Trp Leu Ile Leu Asp Tyr Val Ser Asp 
        195                 200                 205             


Ile Val Tyr Leu Ile Asp Met Phe Val Arg Thr Arg Thr Gly Tyr Leu 
    210                 215                 220                 


Glu Gln Gly Leu Leu Val Lys Glu Glu Leu Lys Leu Ile Asn Lys Tyr 
225                 230                 235                 240 


Lys Ser Asn Leu Gln Phe Lys Leu Asp Val Leu Ser Leu Ile Pro Thr 
                245                 250                 255     


Asp Leu Leu Tyr Phe Lys Leu Gly Trp Asn Tyr Pro Glu Ile Arg Leu 
            260                 265                 270         


Asn Arg Leu Leu Arg Phe Ser Arg Met Phe Glu Phe Phe Gln Arg Thr 
        275                 280                 285             


Glu Thr Arg Thr Asn Tyr Pro Asn Ile Phe Arg Ile Ser Asn Leu Val 
    290                 295                 300                 


Met Tyr Ile Val Ile Ile Ile His Trp Asn Ala Cys Val Phe Tyr Ser 
305                 310                 315                 320 


Ile Ser Lys Ala Ile Gly Phe Gly Asn Asp Thr Trp Val Tyr Pro Asp 
                325                 330                 335     


Ile Asn Asp Pro Glu Phe Gly Arg Leu Ala Arg Lys Tyr Val Tyr Ser 
            340                 345                 350         


Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu Thr Pro Pro 
        355                 360                 365             


Pro Val Arg Asp Ser Glu Tyr Val Phe Val Val Val Asp Phe Leu Ile 
    370                 375                 380                 


Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Ile Gly Ser Met Ile 
385                 390                 395                 400 


Ser Asn Met Asn Ala Ala Arg Ala Glu Phe Gln Ala Arg Ile Asp Ala 
                405                 410                 415     


Ile Lys Gln Tyr Met His Phe Arg Asn Val Ser Lys Asp Met Glu Lys 
            420                 425                 430         


Arg Val Ile Lys Trp Phe Asp Tyr Leu Trp Thr Asn Lys Lys Thr Val 
        435                 440                 445             


Asp Glu Lys Glu Val Leu Lys Tyr Leu Pro Asp Lys Leu Arg Ala Glu 
    450                 455                 460                 


Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val Arg Ile Phe 
465                 470                 475                 480 


Ala Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu Gln 
                485                 490                 495     


Pro Gln Val Tyr Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp Ile 
            500                 505                 510         


Gly Arg Glu Met Tyr Ile Ile Lys Glu Gly Lys Leu Ala Val Val Ala 
        515                 520                 525             


Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly Ser Tyr Phe 
    530                 535                 540                 


Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ala Gly Asn Arg 
545                 550                 555                 560 


Arg Thr Ala Asn Ile Lys Ser Ile Gly Tyr Ser Asp Leu Phe Cys Leu 
                565                 570                 575     


Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro Asp Ala Lys 
            580                 585                 590         


Thr Met Leu Glu Glu Lys Gly Lys Gln Ile Leu Met Lys Asp Gly Leu 
        595                 600                 605             


Leu Asp Leu Asn Ile Ala Asn Ala Gly Ser Asp Pro Lys Asp Leu Glu 
    610                 615                 620                 


Glu Lys Val Thr Arg Met Glu Gly Ser Val Asp Leu Leu Gln Thr Arg 
625                 630                 635                 640 


Phe Ala Arg Ile Leu Ala Glu Tyr Glu Ser Met Gln Gln Lys Leu Lys 
                645                 650                 655     


Gln Arg Leu Thr Lys Val Glu Lys Phe Leu Lys Pro Leu Ile Asp Thr 
            660                 665                 670         


Glu Phe Ser Ser Ile Glu Gly Pro Gly Ala Glu Ser Gly Pro Ile Asp 
        675                 680                 685             


Ser Thr 
    690 


<210>  17
<211>  2479
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(2479)
<223>  CEP290 (centrosomal protein of 290 kDa), isoform 1

<400>  17

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Ile Ser Gly Ile Glu  Ser Asp Asp His Cys  Gln Arg Glu 
    2045                 2050                 2055             


Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu Ser Ser  Glu Asn Ile 
    2060                 2065                 2070             


Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn Lys Asp  Leu Pro Arg 
    2075                 2080                 2085             


Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu Met Cys  Glu Phe Leu 
    2090                 2095                 2100             


Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys Leu Gly  His Val Arg 
    2105                 2110                 2115             


Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro Glu Leu  Glu Lys Thr 
    2120                 2125                 2130             


Ile Gly  Leu Met Lys Lys Val  Val Glu Lys Val Gln  Arg Glu Asn 
    2135                 2140                 2145             


Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu Thr Ser  Glu Lys Met 
    2150                 2155                 2160             


Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu Lys Ala  Glu Leu Glu 
    2165                 2170                 2175             


Lys Leu  Lys Ala His Leu Gly  His Gln Leu Ser Met  His Tyr Glu 
    2180                 2185                 2190             


Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg 
    2195                 2200                 2205             


Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu 
    2210                 2215                 2220             


Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr 
    2225                 2230                 2235             


Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser 
    2240                 2245                 2250             


Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser 
    2255                 2260                 2265             


Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu 
    2270                 2275                 2280             


Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln 
    2285                 2290                 2295             


Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr 
    2300                 2305                 2310             


Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile Leu Lys  His Val Pro 
    2315                 2320                 2325             


Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val 
    2330                 2335                 2340             


Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu 
    2345                 2350                 2355             


Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser 
    2360                 2365                 2370             


Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu 
    2375                 2380                 2385             


Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu Lys Gln  His Leu Lys 
    2390                 2395                 2400             


Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro 
    2405                 2410                 2415             


Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu 
    2420                 2425                 2430             


Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu 
    2435                 2440                 2445             


Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser 
    2450                 2455                 2460             


Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile 
    2465                 2470                 2475             


Tyr 
    


<210>  18
<211>  1406
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1406)
<223>  CRB1 (protein crumbs homolog 1), isoform 1

<400>  18

Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Thr 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Thr Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Thr Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Thr Cys Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Thr Cys Ile Cys Pro His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu 
    210                 215                 220                 


Ile Asp Glu Cys Trp Ser Gln Pro Cys Leu Asn Gly Ala Thr Cys Gln 
225                 230                 235                 240 


Asp Ala Leu Gly Ala Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly 
                245                 250                 255     


Asp His Cys Glu Leu Asn Thr Asp Glu Cys Ala Ser Gln Pro Cys Leu 
            260                 265                 270         


His Gly Gly Leu Cys Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys 
        275                 280                 285             


Thr Gly Ser Gly Phe Thr Gly Thr His Cys Glu Thr Leu Met Pro Leu 
    290                 295                 300                 


Cys Trp Ser Lys Pro Cys His Asn Asn Ala Thr Cys Glu Asp Ser Val 
305                 310                 315                 320 


Asp Asn Tyr Thr Cys His Cys Trp Pro Gly Tyr Thr Gly Ala Gln Cys 
                325                 330                 335     


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
            340                 345                 350         


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly 
        355                 360                 365             


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
    370                 375                 380                 


Cys Gln Pro Gly Phe Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu 
385                 390                 395                 400 


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro 
                405                 410                 415     


Gly Asn Tyr Thr Cys His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe 
            420                 425                 430         


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln 
        435                 440                 445             


Gln Cys Leu Asn Asn Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln 
    450                 455                 460                 


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys 
465                 470                 475                 480 


Glu Ile Ala Thr Thr Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
                485                 490                 495     


Lys Ser Gly Ser Val Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu 
            500                 505                 510         


Arg Phe Gln Thr Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
        515                 520                 525             


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
    530                 535                 540                 


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
545                 550                 555                 560 


Asn Thr Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
                565                 570                 575     


Ala Val Thr Leu Thr Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
            580                 585                 590         


Ala Lys Ala Pro Thr Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
        595                 600                 605             


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly 
    610                 615                 620                 


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val 
625                 630                 635                 640 


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu 
                645                 650                 655     


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
            660                 665                 670         


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
        675                 680                 685             


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
    690                 695                 700                 


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
705                 710                 715                 720 


Ser Thr Gly Tyr Val Ile Phe Thr Leu Asp Glu Ser Tyr Gly Asp Thr 
                725                 730                 735     


Ile Ser Leu Ser Met Phe Val Arg Thr Leu Gln Pro Ser Gly Leu Leu 
            740                 745                 750         


Leu Ala Leu Glu Asn Ser Thr Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
        755                 760                 765             


Arg Gly Arg Leu Ala Met Leu Thr Pro Asn Ser Pro Lys Leu Val Val 
    770                 775                 780                 


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
785                 790                 795                 800 


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
                805                 810                 815     


Ile Ser Ala Ser Thr Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
            820                 825                 830         


Gly Gly Leu Pro Asp Lys Gln Glu Thr Glu Leu Asn Gly Gly Phe Phe 
        835                 840                 845             


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
    850                 855                 860                 


Phe Pro Asn Pro Thr Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
865                 870                 875                 880 


Val Thr Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
                885                 890                 895     


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
            900                 905                 910         


Cys Pro Ala Leu Thr Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
        915                 920                 925             


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
    930                 935                 940                 


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
945                 950                 955                 960 


Ile Leu Phe Arg Ser Asn Gly Asn Ile Thr Arg Glu Leu Thr Asn Ile 
                965                 970                 975     


Thr Phe Gly Phe Arg Thr Arg Asp Ala Asn Val Ile Ile Leu His Ala 
            980                 985                 990         


Glu Lys Glu Pro Glu Phe Leu Asn  Ile Ser Ile Gln Asp  Ser Arg Leu 
        995                 1000                 1005             


Phe Phe  Gln Leu Gln Ser Gly  Asn Ser Phe Tyr Met  Leu Ser Leu 
    1010                 1015                 1020             


Thr Ser  Leu Gln Ser Val Asn  Asp Gly Thr Trp His  Glu Val Thr 
    1025                 1030                 1035             


Leu Ser  Met Thr Asp Pro Leu  Ser Gln Thr Ser Arg  Trp Gln Met 
    1040                 1045                 1050             


Glu Val  Asp Asn Glu Thr Pro  Phe Val Thr Ser Thr  Ile Ala Thr 
    1055                 1060                 1065             


Gly Ser  Leu Asn Phe Leu Lys  Asp Asn Thr Asp Ile  Tyr Val Gly 
    1070                 1075                 1080             


Asp Arg  Ala Ile Asp Asn Ile  Lys Gly Leu Gln Gly  Cys Leu Ser 
    1085                 1090                 1095             


Thr Ile  Glu Ile Gly Gly Ile  Tyr Leu Ser Tyr Phe  Glu Asn Val 
    1100                 1105                 1110             


His Gly  Phe Ile Asn Lys Pro  Gln Glu Glu Gln Phe  Leu Lys Ile 
    1115                 1120                 1125             


Ser Thr  Asn Ser Val Val Thr  Gly Cys Leu Gln Leu  Asn Val Cys 
    1130                 1135                 1140             


Asn Ser  Asn Pro Cys Leu His  Gly Gly Asn Cys Glu  Asp Ile Tyr 
    1145                 1150                 1155             


Ser Ser  Tyr His Cys Ser Cys  Pro Leu Gly Trp Ser  Gly Lys His 
    1160                 1165                 1170             


Cys Glu  Leu Asn Ile Asp Glu  Cys Phe Ser Asn Pro  Cys Ile His 
    1175                 1180                 1185             


Gly Asn  Cys Ser Asp Arg Val  Ala Ala Tyr His Cys  Thr Cys Glu 
    1190                 1195                 1200             


Pro Gly  Tyr Thr Gly Val Asn  Cys Glu Val Asp Ile  Asp Asn Cys 
    1205                 1210                 1215             


Gln Ser  His Gln Cys Ala Asn  Gly Ala Thr Cys Ile  Ser His Thr 
    1220                 1225                 1230             


Asn Gly  Tyr Ser Cys Leu Cys  Phe Gly Asn Phe Thr  Gly Lys Phe 
    1235                 1240                 1245             


Cys Arg  Gln Ser Arg Leu Pro  Ser Thr Val Cys Gly  Asn Glu Lys 
    1250                 1255                 1260             


Thr Asn  Leu Thr Cys Tyr Asn  Gly Gly Asn Cys Thr  Glu Phe Gln 
    1265                 1270                 1275             


Thr Glu  Leu Lys Cys Met Cys  Arg Pro Gly Phe Thr  Gly Glu Trp 
    1280                 1285                 1290             


Cys Glu  Lys Asp Ile Asp Glu  Cys Ala Ser Asp Pro  Cys Val Asn 
    1295                 1300                 1305             


Gly Gly  Leu Cys Gln Asp Leu  Leu Asn Lys Phe Gln  Cys Leu Cys 
    1310                 1315                 1320             


Asp Val  Ala Phe Ala Gly Glu  Arg Cys Glu Val Asp  Leu Ala Asp 
    1325                 1330                 1335             


Asp Leu  Ile Ser Asp Ile Phe  Thr Thr Ile Gly Ser  Val Thr Val 
    1340                 1345                 1350             


Ala Leu  Leu Leu Ile Leu Leu  Leu Ala Ile Val Ala  Ser Val Val 
    1355                 1360                 1365             


Thr Ser  Asn Lys Arg Ala Thr  Gln Gly Thr Tyr Ser  Pro Ser Arg 
    1370                 1375                 1380             


Gln Glu  Lys Glu Gly Ser Arg  Val Glu Met Trp Asn  Leu Met Pro 
    1385                 1390                 1395             


Pro Pro  Ala Met Glu Arg Leu  Ile 
    1400                 1405     


<210>  19
<211>  1285
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1285)
<223>  CRB2 (protein crumbs homolog 2)

<400>  19

Met Ala Leu Ala Arg Pro Gly Thr Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Thr Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Thr Glu Cys Gln Ala Thr Glu Ser Gly Gly Tyr Thr Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Thr Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Thr Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Thr Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Thr Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Thr Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Thr Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Thr Gly Tyr Glu Gly Thr His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr Gly Cys 
385                 390                 395                 400 


Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn Asp Thr 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln Ala Thr 
                485                 490                 495     


Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser Ala Thr 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Thr Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Thr His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Thr Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Thr Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr 
            820                 825                 830         


Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu Val Pro Asp 
    850                 855                 860                 


Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly Pro Pro Ala 
865                 870                 875                 880 


Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu 
                885                 890                 895     


Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala 
            900                 905                 910         


Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser 
        915                 920                 925             


Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu 
    930                 935                 940                 


Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg 
945                 950                 955                 960 


Leu Ala Met Glu Arg Pro Ala Ala Thr Thr Ser Arg Trp Leu Leu Trp 
                965                 970                 975     


Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu Ala Ser Asp 
            980                 985                 990         


Leu Gly Phe Leu Gln Gly Pro Gly  Ala Val Arg Ile Leu  Leu Ala Glu 
        995                 1000                 1005             


Asn Phe  Thr Gly Cys Leu Gly  Arg Val Ala Leu Gly  Gly Leu Pro 
    1010                 1015                 1020             


Leu Pro  Leu Ala Arg Pro Arg  Pro Gly Ala Ala Pro  Gly Ala Arg 
    1025                 1030                 1035             


Glu His  Phe Ala Ser Trp Pro  Gly Thr Pro Ala Pro  Ile Leu Gly 
    1040                 1045                 1050             


Cys Arg  Gly Ala Pro Val Cys  Ala Pro Ser Pro Cys  Leu His Asp 
    1055                 1060                 1065             


Gly Ala  Cys Arg Asp Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly 
    1070                 1075                 1080             


Pro Gly  Trp Glu Gly Pro Arg  Cys Glu Ala His Val  Asp Pro Cys 
    1085                 1090                 1095             


His Ser  Ala Pro Cys Ala Arg  Gly Arg Cys His Thr  His Pro Asp 
    1100                 1105                 1110             


Gly Arg  Phe Glu Cys Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg 
    1115                 1120                 1125             


Cys Arg  Leu Pro Val Pro Ser  Lys Glu Cys Ser Leu  Asn Val Thr 
    1130                 1135                 1140             


Cys Leu  Asp Gly Ser Pro Cys  Glu Gly Gly Ser Pro  Ala Ala Asn 
    1145                 1150                 1155             


Cys Ser  Cys Leu Glu Gly Leu  Ala Gly Gln Arg Cys  Gln Val Pro 
    1160                 1165                 1170             


Thr Leu  Pro Cys Glu Ala Asn  Pro Cys Leu Asn Gly  Gly Thr Cys 
    1175                 1180                 1185             


Arg Ala  Ala Gly Gly Val Ser  Glu Cys Ile Cys Asn  Ala Arg Phe 
    1190                 1195                 1200             


Ser Gly  Gln Phe Cys Glu Val  Ala Lys Gly Leu Pro  Leu Pro Leu 
    1205                 1210                 1215             


Pro Phe  Pro Leu Leu Glu Val  Ala Val Pro Ala Ala  Cys Ala Cys 
    1220                 1225                 1230             


Leu Leu  Leu Leu Leu Leu Gly  Leu Leu Ser Gly Ile  Leu Ala Ala 
    1235                 1240                 1245             


Arg Lys  Arg Arg Gln Ser Glu  Gly Thr Tyr Ser Pro  Ser Gln Gln 
    1250                 1255                 1260             


Glu Val  Ala Gly Ala Arg Leu  Glu Met Asp Ser Val  Leu Lys Val 
    1265                 1270                 1275             


Pro Pro  Glu Glu Arg Leu Ile  
    1280                 1285 


<210>  20
<211>  299
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(299)
<223>  CRX (cone rod honmeobox protein)

<400>  20

Met Met Ala Tyr Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 
1               5                   10                  15      


Ala Leu Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 
            20                  25                  30          


Pro Ser Ala Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg 
        35                  40                  45              


Ser Gln Leu Glu Glu Leu Glu Ala Leu Phe Ala Lys Thr Gln Tyr Pro 
    50                  55                  60                  


Asp Val Tyr Ala Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu 
65                  70                  75                  80  


Ser Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln 
                85                  90                  95      


Gln Arg Gln Gln Gln Lys Gln Gln Gln Gln Pro Pro Gly Gly Gln Ala 
            100                 105                 110         


Lys Ala Arg Pro Ala Lys Arg Lys Ala Gly Thr Ser Pro Arg Pro Ser 
        115                 120                 125             


Thr Asp Val Cys Pro Asp Pro Leu Gly Ile Ser Asp Ser Tyr Ser Pro 
    130                 135                 140                 


Pro Leu Pro Gly Pro Ser Gly Ser Pro Thr Thr Ala Val Ala Thr Val 
145                 150                 155                 160 


Ser Ile Trp Ser Pro Ala Ser Glu Ser Pro Leu Pro Glu Ala Gln Arg 
                165                 170                 175     


Ala Gly Leu Val Ala Ser Gly Pro Ser Leu Thr Ser Ala Pro Tyr Ala 
            180                 185                 190         


Met Thr Tyr Ala Pro Ala Ser Ala Phe Cys Ser Ser Pro Ser Ala Tyr 
        195                 200                 205             


Gly Ser Pro Ser Ser Tyr Phe Ser Gly Leu Asp Pro Tyr Leu Ser Pro 
    210                 215                 220                 


Met Val Pro Gln Leu Gly Gly Pro Ala Leu Ser Pro Leu Ser Gly Pro 
225                 230                 235                 240 


Ser Val Gly Pro Ser Leu Ala Gln Ser Pro Thr Ser Leu Ser Gly Gln 
                245                 250                 255     


Ser Tyr Gly Ala Tyr Ser Pro Val Asp Ser Leu Glu Phe Lys Asp Pro 
            260                 265                 270         


Thr Gly Thr Trp Lys Phe Thr Tyr Asn Pro Met Asp Pro Leu Asp Tyr 
        275                 280                 285             


Lys Asp Gln Ser Ala Trp Lys Phe Gln Ile Leu 
    290                 295                 


<210>  21
<211>  6306
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6306)
<223>  GPR98 (G-protein coupled receptor 98)

<400>  21

Met Ser Val Phe Leu Gly Pro Gly Met Pro Ser Ala Ser Leu Leu Val 
1               5                   10                  15      


Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe Gly Glu Thr Glu 
            20                  25                  30          


Ile Arg Phe Thr Gly Gln Thr Glu Phe Val Val Asn Glu Thr Ser Thr 
        35                  40                  45              


Thr Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu Pro Ala Asn Val 
    50                  55                  60                  


Thr Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly Asp Phe Phe Asp 
65                  70                  75                  80  


Thr Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Thr Asn Arg Thr Val 
                85                  90                  95      


Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro Asp Glu Thr Phe 
            100                 105                 110         


Ile Phe His Leu Thr Leu Gln Lys Pro Ser Ala Asn Val Lys Leu Gly 
        115                 120                 125             


Trp Pro Arg Thr Val Thr Val Thr Ile Leu Ser Asn Asp Asn Ala Phe 
    130                 135                 140                 


Gly Ile Ile Ser Phe Asn Met Leu Pro Ser Ile Ala Val Ser Glu Pro 
145                 150                 155                 160 


Lys Gly Arg Asn Glu Ser Met Pro Leu Thr Leu Ile Arg Glu Lys Gly 
                165                 170                 175     


Thr Tyr Gly Met Val Met Val Thr Phe Glu Val Glu Gly Gly Pro Asn 
            180                 185                 190         


Pro Pro Asp Glu Asp Leu Ser Pro Val Lys Gly Asn Ile Thr Phe Pro 
        195                 200                 205             


Pro Gly Arg Ala Thr Val Ile Tyr Asn Leu Thr Val Leu Asp Asp Glu 
    210                 215                 220                 


Val Pro Glu Asn Asp Glu Ile Phe Leu Ile Gln Leu Lys Ser Val Glu 
225                 230                 235                 240 


Gly Gly Ala Glu Ile Asn Thr Ser Arg Asn Ser Ile Glu Ile Ile Ile 
                245                 250                 255     


Lys Lys Asn Asp Ser Pro Val Arg Phe Leu Gln Ser Ile Tyr Leu Val 
            260                 265                 270         


Pro Glu Glu Asp His Ile Leu Ile Ile Pro Val Val Arg Gly Lys Asp 
        275                 280                 285             


Asn Asn Gly Asn Leu Ile Gly Ser Asp Glu Tyr Glu Val Ser Ile Ser 
    290                 295                 300                 


Tyr Ala Val Thr Thr Gly Asn Ser Thr Ala His Ala Gln Gln Asn Leu 
305                 310                 315                 320 


Asp Phe Ile Asp Leu Gln Pro Asn Thr Thr Val Val Phe Pro Pro Phe 
                325                 330                 335     


Ile His Glu Ser His Leu Lys Phe Gln Ile Val Asp Asp Thr Ile Pro 
            340                 345                 350         


Glu Ile Ala Glu Ser Phe His Ile Met Leu Leu Lys Asp Thr Leu Gln 
        355                 360                 365             


Gly Asp Ala Val Leu Ile Ser Pro Ser Val Val Gln Val Thr Ile Lys 
    370                 375                 380                 


Pro Asn Asp Lys Pro Tyr Gly Val Leu Ser Phe Asn Ser Val Leu Phe 
385                 390                 395                 400 


Glu Arg Thr Val Ile Ile Asp Glu Asp Arg Ile Ser Arg Tyr Glu Glu 
                405                 410                 415     


Ile Thr Val Val Arg Asn Gly Gly Thr His Gly Asn Val Ser Ala Asn 
            420                 425                 430         


Trp Val Leu Thr Arg Asn Ser Thr Asp Pro Ser Pro Val Thr Ala Asp 
        435                 440                 445             


Ile Arg Pro Ser Ser Gly Val Leu His Phe Ala Gln Gly Gln Met Leu 
    450                 455                 460                 


Ala Thr Ile Pro Leu Thr Val Val Asp Asp Asp Leu Pro Glu Glu Ala 
465                 470                 475                 480 


Glu Ala Tyr Leu Leu Gln Ile Leu Pro His Thr Ile Arg Gly Gly Ala 
                485                 490                 495     


Glu Val Ser Glu Pro Ala Glu Leu Leu Phe Tyr Ile Gln Asp Ser Asp 
            500                 505                 510         


Asp Val Tyr Gly Leu Ile Thr Phe Phe Pro Met Glu Asn Gln Lys Ile 
        515                 520                 525             


Glu Ser Ser Pro Gly Glu Arg Tyr Leu Ser Leu Ser Phe Thr Arg Leu 
    530                 535                 540                 


Gly Gly Thr Lys Gly Asp Val Arg Leu Leu Tyr Ser Val Leu Tyr Ile 
545                 550                 555                 560 


Pro Ala Gly Ala Val Asp Pro Leu Gln Ala Lys Glu Gly Ile Leu Asn 
                565                 570                 575     


Ile Ser Arg Arg Asn Asp Leu Ile Phe Pro Glu Gln Lys Thr Gln Val 
            580                 585                 590         


Thr Thr Lys Leu Pro Ile Arg Asn Asp Ala Phe Leu Gln Asn Gly Ala 
        595                 600                 605             


His Phe Leu Val Gln Leu Glu Thr Val Glu Leu Leu Asn Ile Ile Pro 
    610                 615                 620                 


Leu Ile Pro Pro Ile Ser Pro Arg Phe Gly Glu Ile Cys Asn Ile Ser 
625                 630                 635                 640 


Leu Leu Val Thr Pro Ala Ile Ala Asn Gly Glu Ile Gly Phe Leu Ser 
                645                 650                 655     


Asn Leu Pro Ile Ile Leu His Glu Pro Glu Asp Phe Ala Ala Glu Val 
            660                 665                 670         


Val Tyr Ile Pro Leu His Arg Asp Gly Thr Asp Gly Gln Ala Thr Val 
        675                 680                 685             


Tyr Trp Ser Leu Lys Pro Ser Gly Phe Asn Ser Lys Ala Val Thr Pro 
    690                 695                 700                 


Asp Asp Ile Gly Pro Phe Asn Gly Ser Val Leu Phe Leu Ser Gly Gln 
705                 710                 715                 720 


Ser Asp Thr Thr Ile Asn Ile Thr Ile Lys Gly Asp Asp Ile Pro Glu 
                725                 730                 735     


Met Asn Glu Thr Val Thr Leu Ser Leu Asp Arg Val Asn Val Glu Asn 
            740                 745                 750         


Gln Val Leu Lys Ser Gly Tyr Thr Ser Arg Asp Leu Ile Ile Leu Glu 
        755                 760                 765             


Asn Asp Asp Pro Gly Gly Val Phe Glu Phe Ser Pro Ala Ser Arg Gly 
    770                 775                 780                 


Pro Tyr Val Ile Lys Glu Gly Glu Ser Val Glu Leu His Ile Ile Arg 
785                 790                 795                 800 


Ser Arg Gly Ser Leu Val Lys Gln Phe Leu His Tyr Arg Val Glu Pro 
                805                 810                 815     


Arg Asp Ser Asn Glu Phe Tyr Gly Asn Thr Gly Val Leu Glu Phe Lys 
            820                 825                 830         


Pro Gly Glu Arg Glu Ile Val Ile Thr Leu Leu Ala Arg Leu Asp Gly 
        835                 840                 845             


Ile Pro Glu Leu Asp Glu His Tyr Trp Val Val Leu Ser Ser His Gly 
    850                 855                 860                 


Glu Arg Glu Ser Lys Leu Gly Ser Ala Thr Ile Val Asn Ile Thr Ile 
865                 870                 875                 880 


Leu Lys Asn Asp Asp Pro His Gly Ile Ile Glu Phe Val Ser Asp Gly 
                885                 890                 895     


Leu Ile Val Met Ile Asn Glu Ser Lys Gly Asp Ala Ile Tyr Ser Ala 
            900                 905                 910         


Val Tyr Asp Val Val Arg Asn Arg Gly Asn Phe Gly Asp Val Ser Val 
        915                 920                 925             


Ser Trp Val Val Ser Pro Asp Phe Thr Gln Asp Val Phe Pro Val Gln 
    930                 935                 940                 


Gly Thr Val Val Phe Gly Asp Gln Glu Phe Ser Lys Asn Ile Thr Ile 
945                 950                 955                 960 


Tyr Ser Leu Pro Asp Glu Ile Pro Glu Glu Met Glu Glu Phe Thr Val 
                965                 970                 975     


Ile Leu Leu Asn Gly Thr Gly Gly Ala Lys Val Gly Asn Arg Thr Thr 
            980                 985                 990         


Ala Thr Leu Arg Ile Arg Arg Asn  Asp Asp Pro Ile Tyr  Phe Ala Glu 
        995                 1000                 1005             


Pro Arg  Val Val Arg Val Gln  Glu Gly Glu Thr Ala  Asn Phe Thr 
    1010                 1015                 1020             


Val Leu  Arg Asn Gly Ser Val  Asp Val Thr Cys Met  Val Gln Tyr 
    1025                 1030                 1035             


Ala Thr  Lys Asp Gly Lys Ala  Thr Ala Arg Glu Arg  Asp Phe Ile 
    1040                 1045                 1050             


Pro Val  Glu Lys Gly Glu Thr  Leu Ile Phe Glu Val  Gly Ser Arg 
    1055                 1060                 1065             


Gln Gln  Ser Ile Ser Ile Phe  Val Asn Glu Asp Gly  Ile Pro Glu 
    1070                 1075                 1080             


Thr Asp  Glu Pro Phe Tyr Ile  Ile Leu Leu Asn Ser  Thr Gly Asp 
    1085                 1090                 1095             


Thr Val  Val Tyr Gln Tyr Gly  Val Ala Thr Val Ile  Ile Glu Ala 
    1100                 1105                 1110             


Asn Asp  Asp Pro Asn Gly Ile  Phe Ser Leu Glu Pro  Ile Asp Lys 
    1115                 1120                 1125             


Ala Val  Glu Glu Gly Lys Thr  Asn Ala Phe Trp Ile  Leu Arg His 
    1130                 1135                 1140             


Arg Gly  Tyr Phe Gly Ser Val  Ser Val Ser Trp Gln  Leu Phe Gln 
    1145                 1150                 1155             


Asn Asp  Ser Ala Leu Gln Pro  Gly Gln Glu Phe Tyr  Glu Thr Ser 
    1160                 1165                 1170             


Gly Thr  Val Asn Phe Met Asp  Gly Glu Glu Ala Lys  Pro Ile Ile 
    1175                 1180                 1185             


Leu His  Ala Phe Pro Asp Lys  Ile Pro Glu Phe Asn  Glu Phe Tyr 
    1190                 1195                 1200             


Phe Leu  Lys Leu Val Asn Ile  Ser Gly Gly Ser Pro  Gly Pro Gly 
    1205                 1210                 1215             


Gly Gln  Leu Ala Glu Thr Asn  Leu Gln Val Thr Val  Met Val Pro 
    1220                 1225                 1230             


Phe Asn  Asp Asp Pro Phe Gly  Val Phe Ile Leu Asp  Pro Glu Cys 
    1235                 1240                 1245             


Leu Glu  Arg Glu Val Ala Glu  Asp Val Leu Ser Glu  Asp Asp Met 
    1250                 1255                 1260             


Ser Tyr  Ile Thr Asn Phe Thr  Ile Leu Arg Gln Gln  Gly Val Phe 
    1265                 1270                 1275             


Gly Asp  Val Gln Leu Gly Trp  Glu Ile Leu Ser Ser  Glu Phe Pro 
    1280                 1285                 1290             


Ala Gly  Leu Pro Pro Met Ile  Asp Phe Leu Leu Val  Gly Ile Phe 
    1295                 1300                 1305             


Pro Thr  Thr Val His Leu Gln  Gln His Met Arg Arg  His His Ser 
    1310                 1315                 1320             


Gly Thr  Asp Ala Leu Tyr Phe  Thr Gly Leu Glu Gly  Ala Phe Gly 
    1325                 1330                 1335             


Thr Val  Asn Pro Lys Tyr His  Pro Ser Arg Asn Asn  Thr Ile Ala 
    1340                 1345                 1350             


Asn Phe  Thr Phe Ser Ala Trp  Val Met Pro Asn Ala  Asn Thr Asn 
    1355                 1360                 1365             


Gly Phe  Ile Ile Ala Lys Asp  Asp Gly Asn Gly Ser  Ile Tyr Tyr 
    1370                 1375                 1380             


Gly Val  Lys Ile Gln Thr Asn  Glu Ser His Val Thr  Leu Ser Leu 
    1385                 1390                 1395             


His Tyr  Lys Thr Leu Gly Ser  Asn Ala Thr Tyr Ile  Ala Lys Thr 
    1400                 1405                 1410             


Thr Val  Met Lys Tyr Leu Glu  Glu Ser Val Trp Leu  His Leu Leu 
    1415                 1420                 1425             


Ile Ile  Leu Glu Asp Gly Ile  Ile Glu Phe Tyr Leu  Asp Gly Asn 
    1430                 1435                 1440             


Ala Met  Pro Arg Gly Ile Lys  Ser Leu Lys Gly Glu  Ala Ile Thr 
    1445                 1450                 1455             


Asp Gly  Pro Gly Ile Leu Arg  Ile Gly Ala Gly Ile  Asn Gly Asn 
    1460                 1465                 1470             


Asp Arg  Phe Thr Gly Leu Met  Gln Asp Val Arg Ser  Tyr Glu Arg 
    1475                 1480                 1485             


Lys Leu  Thr Leu Glu Glu Ile  Tyr Glu Leu His Ala  Met Pro Ala 
    1490                 1495                 1500             


Lys Ser  Asp Leu His Pro Ile  Ser Gly Tyr Leu Glu  Phe Arg Gln 
    1505                 1510                 1515             


Gly Glu  Thr Asn Lys Ser Phe  Ile Ile Ser Ala Arg  Asp Asp Asn 
    1520                 1525                 1530             


Asp Glu  Glu Gly Glu Glu Leu  Phe Ile Leu Lys Leu  Val Ser Val 
    1535                 1540                 1545             


Tyr Gly  Gly Ala Arg Ile Ser  Glu Glu Asn Thr Thr  Ala Arg Leu 
    1550                 1555                 1560             


Thr Ile  Gln Lys Ser Asp Asn  Ala Asn Gly Leu Phe  Gly Phe Thr 
    1565                 1570                 1575             


Gly Ala  Cys Ile Pro Glu Ile  Ala Glu Glu Gly Ser  Thr Ile Ser 
    1580                 1585                 1590             


Cys Val  Val Glu Arg Thr Arg  Gly Ala Leu Asp Tyr  Val His Val 
    1595                 1600                 1605             


Phe Tyr  Thr Ile Ser Gln Ile  Glu Thr Asp Gly Ile  Asn Tyr Leu 
    1610                 1615                 1620             


Val Asp  Asp Phe Ala Asn Ala  Ser Gly Thr Ile Thr  Phe Leu Pro 
    1625                 1630                 1635             


Trp Gln  Arg Ser Glu Val Leu  Asn Ile Tyr Val Leu  Asp Asp Asp 
    1640                 1645                 1650             


Ile Pro  Glu Leu Asn Glu Tyr  Phe Arg Val Thr Leu  Val Ser Ala 
    1655                 1660                 1665             


Ile Pro  Gly Asp Gly Lys Leu  Gly Ser Thr Pro Thr  Ser Gly Ala 
    1670                 1675                 1680             


Ser Ile  Asp Pro Glu Lys Glu  Thr Thr Asp Ile Thr  Ile Lys Ala 
    1685                 1690                 1695             


Ser Asp  His Pro Tyr Gly Leu  Leu Gln Phe Ser Thr  Gly Leu Pro 
    1700                 1705                 1710             


Pro Gln  Pro Lys Asp Ala Met  Thr Leu Pro Ala Ser  Ser Val Pro 
    1715                 1720                 1725             


His Ile  Thr Val Glu Glu Glu  Asp Gly Glu Ile Arg  Leu Leu Val 
    1730                 1735                 1740             


Ile Arg  Ala Gln Gly Leu Leu  Gly Arg Val Thr Ala  Glu Phe Arg 
    1745                 1750                 1755             


Thr Val  Ser Leu Thr Ala Phe  Ser Pro Glu Asp Tyr  Gln Asn Val 
    1760                 1765                 1770             


Ala Gly  Thr Leu Glu Phe Gln  Pro Gly Glu Arg Tyr  Lys Tyr Ile 
    1775                 1780                 1785             


Phe Ile  Asn Ile Thr Asp Asn  Ser Ile Pro Glu Leu  Glu Lys Ser 
    1790                 1795                 1800             


Phe Lys  Val Glu Leu Leu Asn  Leu Glu Gly Gly Val  Ala Glu Leu 
    1805                 1810                 1815             


Phe Arg  Val Asp Gly Ser Gly  Ser Gly Asp Gly Asp  Met Glu Phe 
    1820                 1825                 1830             


Phe Leu  Pro Thr Ile His Lys  Arg Ala Ser Leu Gly  Val Ala Ser 
    1835                 1840                 1845             


Gln Ile  Leu Val Thr Ile Ala  Ala Ser Asp His Ala  His Gly Val 
    1850                 1855                 1860             


Phe Glu  Phe Ser Pro Glu Ser  Leu Phe Val Ser Gly  Thr Glu Pro 
    1865                 1870                 1875             


Glu Asp  Gly Tyr Ser Thr Val  Thr Leu Asn Val Ile  Arg His His 
    1880                 1885                 1890             


Gly Thr  Leu Ser Pro Val Thr  Leu His Trp Asn Ile  Asp Ser Asp 
    1895                 1900                 1905             


Pro Asp  Gly Asp Leu Ala Phe  Thr Ser Gly Asn Ile  Thr Phe Glu 
    1910                 1915                 1920             


Ile Gly  Gln Thr Ser Ala Asn  Ile Thr Val Glu Ile  Leu Pro Asp 
    1925                 1930                 1935             


Glu Asp  Pro Glu Leu Asp Lys  Ala Phe Ser Val Ser  Val Leu Ser 
    1940                 1945                 1950             


Val Ser  Ser Gly Ser Leu Gly  Ala His Ile Asn Ala  Thr Leu Thr 
    1955                 1960                 1965             


Val Leu  Ala Ser Asp Asp Pro  Tyr Gly Ile Phe Ile  Phe Ser Glu 
    1970                 1975                 1980             


Lys Asn  Arg Pro Val Lys Val  Glu Glu Ala Thr Gln  Asn Ile Thr 
    1985                 1990                 1995             


Leu Ser  Ile Ile Arg Leu Lys  Gly Leu Met Gly Lys  Val Leu Val 
    2000                 2005                 2010             


Ser Tyr  Ala Thr Leu Asp Asp  Met Glu Lys Pro Pro  Tyr Phe Pro 
    2015                 2020                 2025             


Pro Asn  Leu Ala Arg Ala Thr  Gln Gly Arg Asp Tyr  Ile Pro Ala 
    2030                 2035                 2040             


Ser Gly  Phe Ala Leu Phe Gly  Ala Asn Gln Ser Glu  Ala Thr Ile 
    2045                 2050                 2055             


Ala Ile  Ser Ile Leu Asp Asp  Asp Glu Pro Glu Arg  Ser Glu Ser 
    2060                 2065                 2070             


Val Phe  Ile Glu Leu Leu Asn  Ser Thr Leu Val Ala  Lys Val Gln 
    2075                 2080                 2085             


Ser Arg  Ser Ile Pro Asn Ser  Pro Arg Leu Gly Pro  Lys Val Glu 
    2090                 2095                 2100             


Thr Ile  Ala Gln Leu Ile Ile  Ile Ala Asn Asp Asp  Ala Phe Gly 
    2105                 2110                 2115             


Thr Leu  Gln Leu Ser Ala Pro  Ile Val Arg Val Ala  Glu Asn His 
    2120                 2125                 2130             


Val Gly  Pro Ile Ile Asn Val  Thr Arg Thr Gly Gly  Ala Phe Ala 
    2135                 2140                 2145             


Asp Val  Ser Val Lys Phe Lys  Ala Val Pro Ile Thr  Ala Ile Ala 
    2150                 2155                 2160             


Gly Glu  Asp Tyr Ser Ile Ala  Ser Ser Asp Val Val  Leu Leu Glu 
    2165                 2170                 2175             


Gly Glu  Thr Ser Lys Ala Val  Pro Ile Tyr Val Ile  Asn Asp Ile 
    2180                 2185                 2190             


Tyr Pro  Glu Leu Glu Glu Ser  Phe Leu Val Gln Leu  Met Asn Glu 
    2195                 2200                 2205             


Thr Thr  Gly Gly Ala Arg Leu  Gly Ala Leu Thr Glu  Ala Val Ile 
    2210                 2215                 2220             


Ile Ile  Glu Ala Ser Asp Asp  Pro Tyr Gly Leu Phe  Gly Phe Gln 
    2225                 2230                 2235             


Ile Thr  Lys Leu Ile Val Glu  Glu Pro Glu Phe Asn  Ser Val Lys 
    2240                 2245                 2250             


Val Asn  Leu Pro Ile Ile Arg  Asn Ser Gly Thr Leu  Gly Asn Val 
    2255                 2260                 2265             


Thr Val  Gln Trp Val Ala Thr  Ile Asn Gly Gln Leu  Ala Thr Gly 
    2270                 2275                 2280             


Asp Leu  Arg Val Val Ser Gly  Asn Val Thr Phe Ala  Pro Gly Glu 
    2285                 2290                 2295             


Thr Ile  Gln Thr Leu Leu Leu  Glu Val Leu Ala Asp  Asp Val Pro 
    2300                 2305                 2310             


Glu Ile  Glu Glu Val Ile Gln  Val Gln Leu Thr Asp  Ala Ser Gly 
    2315                 2320                 2325             


Gly Gly  Thr Ile Gly Leu Asp  Arg Ile Ala Asn Ile  Ile Ile Pro 
    2330                 2335                 2340             


Ala Asn  Asp Asp Pro Tyr Gly  Thr Val Ala Phe Ala  Gln Met Val 
    2345                 2350                 2355             


Tyr Arg  Val Gln Glu Pro Leu  Glu Arg Ser Ser Cys  Ala Asn Ile 
    2360                 2365                 2370             


Thr Val  Arg Arg Ser Gly Gly  His Phe Gly Arg Leu  Leu Leu Phe 
    2375                 2380                 2385             


Tyr Ser  Thr Ser Asp Ile Asp  Val Val Ala Leu Ala  Met Glu Glu 
    2390                 2395                 2400             


Gly Gln  Asp Leu Leu Ser Tyr  Tyr Glu Ser Pro Ile  Gln Gly Val 
    2405                 2410                 2415             


Pro Asp  Pro Leu Trp Arg Thr  Trp Met Asn Val Ser  Ala Val Gly 
    2420                 2425                 2430             


Glu Pro  Leu Tyr Thr Cys Ala  Thr Leu Cys Leu Lys  Glu Gln Ala 
    2435                 2440                 2445             


Cys Ser  Ala Phe Ser Phe Phe  Ser Ala Ser Glu Gly  Pro Gln Cys 
    2450                 2455                 2460             


Phe Trp  Met Thr Ser Trp Ile  Ser Pro Ala Val Asn  Asn Ser Asp 
    2465                 2470                 2475             


Phe Trp  Thr Tyr Arg Lys Asn  Met Thr Arg Val Ala  Ser Leu Phe 
    2480                 2485                 2490             


Ser Gly  Gln Ala Val Ala Gly  Ser Asp Tyr Glu Pro  Val Thr Arg 
    2495                 2500                 2505             


Gln Trp  Ala Ile Met Gln Glu  Gly Asp Glu Phe Ala  Asn Leu Thr 
    2510                 2515                 2520             


Val Ser  Ile Leu Pro Asp Asp  Phe Pro Glu Met Asp  Glu Ser Phe 
    2525                 2530                 2535             


Leu Ile  Ser Leu Leu Glu Val  His Leu Met Asn Ile  Ser Ala Ser 
    2540                 2545                 2550             


Leu Lys  Asn Gln Pro Thr Ile  Gly Gln Pro Asn Ile  Ser Thr Val 
    2555                 2560                 2565             


Val Ile  Ala Leu Asn Gly Asp  Ala Phe Gly Val Phe  Val Ile Tyr 
    2570                 2575                 2580             


Asn Ile  Ser Pro Asn Thr Ser  Glu Asp Gly Leu Phe  Val Glu Val 
    2585                 2590                 2595             


Gln Glu  Gln Pro Gln Thr Leu  Val Glu Leu Met Ile  His Arg Thr 
    2600                 2605                 2610             


Gly Gly  Ser Leu Gly Gln Val  Ala Val Glu Trp Arg  Val Val Gly 
    2615                 2620                 2625             


Gly Thr  Ala Thr Glu Gly Leu  Asp Phe Ile Gly Ala  Gly Glu Ile 
    2630                 2635                 2640             


Leu Thr  Phe Ala Glu Gly Glu  Thr Lys Lys Thr Val  Ile Leu Thr 
    2645                 2650                 2655             


Ile Leu  Asp Asp Ser Glu Pro  Glu Asp Asp Glu Ser  Ile Ile Val 
    2660                 2665                 2670             


Ser Leu  Val Tyr Thr Glu Gly  Gly Ser Arg Ile Leu  Pro Ser Ser 
    2675                 2680                 2685             


Asp Thr  Val Arg Val Asn Ile  Leu Ala Asn Asp Asn  Val Ala Gly 
    2690                 2695                 2700             


Ile Val  Ser Phe Gln Thr Ala  Ser Arg Ser Val Ile  Gly His Glu 
    2705                 2710                 2715             


Gly Glu  Ile Leu Gln Phe His  Val Ile Arg Thr Phe  Pro Gly Arg 
    2720                 2725                 2730             


Gly Asn  Val Thr Val Asn Trp  Lys Ile Ile Gly Gln  Asn Leu Glu 
    2735                 2740                 2745             


Leu Asn  Phe Ala Asn Phe Ser  Gly Gln Leu Phe Phe  Pro Glu Gly 
    2750                 2755                 2760             


Ser Leu  Asn Thr Thr Leu Phe  Val His Leu Leu Asp  Asp Asn Ile 
    2765                 2770                 2775             


Pro Glu  Glu Lys Glu Val Tyr  Gln Val Ile Leu Tyr  Asp Val Arg 
    2780                 2785                 2790             


Thr Gln  Gly Val Pro Pro Ala  Gly Ile Ala Leu Leu  Asp Ala Gln 
    2795                 2800                 2805             


Gly Tyr  Ala Ala Val Leu Thr  Val Glu Ala Ser Asp  Glu Pro His 
    2810                 2815                 2820             


Gly Val  Leu Asn Phe Ala Leu  Ser Ser Arg Phe Val  Leu Leu Gln 
    2825                 2830                 2835             


Glu Ala  Asn Ile Thr Ile Gln  Leu Phe Ile Asn Arg  Glu Phe Gly 
    2840                 2845                 2850             


Ser Leu  Gly Ala Ile Asn Val  Thr Tyr Thr Thr Val  Pro Gly Met 
    2855                 2860                 2865             


Leu Ser  Leu Lys Asn Gln Thr  Val Gly Asn Leu Ala  Glu Pro Glu 
    2870                 2875                 2880             


Val Asp  Phe Val Pro Ile Ile  Gly Phe Leu Ile Leu  Glu Glu Gly 
    2885                 2890                 2895             


Glu Thr  Ala Ala Ala Ile Asn  Ile Thr Ile Leu Glu  Asp Asp Val 
    2900                 2905                 2910             


Pro Glu  Leu Glu Glu Tyr Phe  Leu Val Asn Leu Thr  Tyr Val Gly 
    2915                 2920                 2925             


Leu Thr  Met Ala Ala Ser Thr  Ser Phe Pro Pro Arg  Leu Asp Ser 
    2930                 2935                 2940             


Glu Gly  Leu Thr Ala Gln Val  Ile Ile Asp Ala Asn  Asp Gly Ala 
    2945                 2950                 2955             


Arg Gly  Val Ile Glu Trp Gln  Gln Ser Arg Phe Glu  Val Asn Glu 
    2960                 2965                 2970             


Thr His  Gly Ser Leu Thr Leu  Val Ala Gln Arg Ser  Arg Glu Pro 
    2975                 2980                 2985             


Leu Gly  His Val Ser Leu Phe  Val Tyr Ala Gln Asn  Leu Glu Ala 
    2990                 2995                 3000             


Gln Val  Gly Leu Asp Tyr Ile  Phe Thr Pro Met Ile  Leu His Phe 
    3005                 3010                 3015             


Ala Asp  Gly Glu Arg Tyr Lys  Asn Val Asn Ile Met  Ile Leu Asp 
    3020                 3025                 3030             


Asp Asp  Ile Pro Glu Gly Asp  Glu Lys Phe Gln Leu  Ile Leu Thr 
    3035                 3040                 3045             


Asn Pro  Ser Pro Gly Leu Glu  Leu Gly Lys Asn Thr  Ile Ala Leu 
    3050                 3055                 3060             


Ile Ile  Val Leu Ala Asn Asp  Asp Gly Pro Gly Val  Leu Ser Phe 
    3065                 3070                 3075             


Asn Asn  Ser Glu His Phe Phe  Leu Arg Glu Pro Thr  Ala Leu Tyr 
    3080                 3085                 3090             


Val Gln  Glu Ser Val Ala Val  Leu Tyr Ile Val Arg  Glu Pro Ala 
    3095                 3100                 3105             


Gln Gly  Leu Phe Gly Thr Val  Thr Val Gln Phe Ile  Val Thr Glu 
    3110                 3115                 3120             


Val Asn  Ser Ser Asn Glu Ser  Lys Asp Leu Thr Pro  Ser Lys Gly 
    3125                 3130                 3135             


Tyr Ile  Val Leu Glu Glu Gly  Val Arg Phe Lys Ala  Leu Gln Ile 
    3140                 3145                 3150             


Ser Ala  Ile Leu Asp Thr Glu  Pro Glu Met Asp Glu  Tyr Phe Val 
    3155                 3160                 3165             


Cys Thr  Leu Phe Asn Pro Thr  Gly Gly Ala Arg Leu  Gly Val His 
    3170                 3175                 3180             


Val Gln  Thr Leu Ile Thr Val  Leu Gln Asn Gln Ala  Pro Leu Gly 
    3185                 3190                 3195             


Leu Phe  Ser Ile Ser Ala Val  Glu Asn Arg Ala Thr  Ser Ile Asp 
    3200                 3205                 3210             


Ile Glu  Glu Ala Asn Arg Thr  Val Tyr Leu Asn Val  Ser Arg Thr 
    3215                 3220                 3225             


Asn Gly  Ile Asp Leu Ala Val  Ser Val Gln Trp Glu  Thr Val Ser 
    3230                 3235                 3240             


Glu Thr  Ala Phe Gly Met Arg  Gly Met Asp Val Val  Phe Ser Val 
    3245                 3250                 3255             


Phe Gln  Ser Phe Leu Asp Glu  Ser Ala Ser Gly Trp  Cys Phe Phe 
    3260                 3265                 3270             


Thr Leu  Glu Asn Leu Ile Tyr  Gly Ile Met Leu Arg  Lys Ser Ser 
    3275                 3280                 3285             


Val Thr  Val Tyr Arg Trp Gln  Gly Ile Phe Ile Pro  Val Glu Asp 
    3290                 3295                 3300             


Leu Asn  Ile Glu Asn Pro Lys  Thr Cys Glu Ala Phe  Asn Ile Gly 
    3305                 3310                 3315             


Phe Ser  Pro Tyr Phe Val Ile  Thr His Glu Glu Arg  Asn Glu Glu 
    3320                 3325                 3330             


Lys Pro  Ser Leu Asn Ser Val  Phe Thr Phe Thr Ser  Gly Phe Lys 
    3335                 3340                 3345             


Leu Phe  Leu Val Gln Thr Ile  Ile Ile Leu Glu Ser  Ser Gln Val 
    3350                 3355                 3360             


Arg Tyr  Phe Thr Ser Asp Ser  Gln Asp Tyr Leu Ile  Ile Ala Ser 
    3365                 3370                 3375             


Gln Arg  Asp Asp Ser Glu Leu  Thr Gln Val Phe Arg  Trp Asn Gly 
    3380                 3385                 3390             


Gly Ser  Phe Val Leu His Gln  Lys Leu Pro Val Arg  Gly Val Leu 
    3395                 3400                 3405             


Thr Val  Ala Leu Phe Asn Lys  Gly Gly Ser Val Phe  Leu Ala Ile 
    3410                 3415                 3420             


Ser Gln  Ala Asn Ala Arg Leu  Asn Ser Leu Leu Phe  Arg Trp Ser 
    3425                 3430                 3435             


Gly Ser  Gly Phe Ile Asn Phe  Gln Glu Val Pro Val  Ser Gly Thr 
    3440                 3445                 3450             


Thr Glu  Val Glu Ala Leu Ser  Ser Ala Asn Asp Ile  Tyr Leu Ile 
    3455                 3460                 3465             


Phe Ala  Glu Asn Val Phe Leu  Gly Asp Gln Asn Ser  Ile Asp Ile 
    3470                 3475                 3480             


Phe Ile  Trp Glu Met Gly Gln  Ser Ser Phe Arg Tyr  Phe Gln Ser 
    3485                 3490                 3495             


Val Asp  Phe Ala Ala Val Asn  Arg Ile His Ser Phe  Thr Pro Ala 
    3500                 3505                 3510             


Ser Gly  Ile Ala His Ile Leu  Leu Ile Gly Gln Asp  Met Ser Ala 
    3515                 3520                 3525             


Leu Tyr  Cys Trp Asn Ser Glu  Arg Asn Gln Phe Ser  Phe Val Leu 
    3530                 3535                 3540             


Glu Val  Pro Ser Ala Tyr Asp  Val Ala Ser Val Thr  Val Lys Ser 
    3545                 3550                 3555             


Leu Asn  Ser Ser Lys Asn Leu  Ile Ala Leu Val Gly  Ala His Ser 
    3560                 3565                 3570             


His Ile  Tyr Glu Leu Ala Tyr  Ile Ser Ser His Ser  Asp Phe Ile 
    3575                 3580                 3585             


Pro Ser  Ser Gly Glu Leu Ile  Phe Glu Pro Gly Glu  Arg Glu Ala 
    3590                 3595                 3600             


Thr Ile  Ala Val Asn Ile Leu  Asp Asp Thr Val Pro  Glu Lys Glu 
    3605                 3610                 3615             


Glu Ser  Phe Lys Val Gln Leu  Lys Asn Pro Lys Gly  Gly Ala Glu 
    3620                 3625                 3630             


Ile Gly  Ile Asn Asp Ser Val  Thr Ile Thr Ile Leu  Ser Asn Asp 
    3635                 3640                 3645             


Asp Ala  Tyr Gly Ile Val Ala  Phe Ala Gln Asn Ser  Leu Tyr Lys 
    3650                 3655                 3660             


Gln Val  Glu Glu Met Glu Gln  Asp Ser Leu Val Thr  Leu Asn Val 
    3665                 3670                 3675             


Glu Arg  Leu Lys Gly Thr Tyr  Gly Arg Ile Thr Ile  Ala Trp Glu 
    3680                 3685                 3690             


Ala Asp  Gly Ser Ile Ser Asp  Ile Phe Pro Thr Ser  Gly Val Ile 
    3695                 3700                 3705             


Leu Phe  Thr Glu Gly Gln Val  Leu Ser Thr Ile Thr  Leu Thr Ile 
    3710                 3715                 3720             


Leu Ala  Asp Asn Ile Pro Glu  Leu Ser Glu Val Val  Ile Val Thr 
    3725                 3730                 3735             


Leu Thr  Arg Ile Thr Thr Glu  Gly Val Glu Asp Ser  Tyr Lys Gly 
    3740                 3745                 3750             


Ala Thr  Ile Asp Gln Asp Arg  Ser Lys Ser Val Ile  Thr Thr Leu 
    3755                 3760                 3765             


Pro Asn  Asp Ser Pro Phe Gly  Leu Val Gly Trp Arg  Ala Ala Ser 
    3770                 3775                 3780             


Val Phe  Ile Arg Val Ala Glu  Pro Lys Glu Asn Thr  Thr Thr Leu 
    3785                 3790                 3795             


Gln Leu  Gln Ile Ala Arg Asp  Lys Gly Leu Leu Gly  Asp Ile Ala 
    3800                 3805                 3810             


Ile His  Leu Arg Ala Gln Pro  Asn Phe Leu Leu His  Val Asp Asn 
    3815                 3820                 3825             


Gln Ala  Thr Glu Asn Glu Asp  Tyr Val Leu Gln Glu  Thr Ile Ile 
    3830                 3835                 3840             


Ile Met  Lys Glu Asn Ile Lys  Glu Ala His Ala Glu  Val Ser Ile 
    3845                 3850                 3855             


Leu Pro  Asp Asp Leu Pro Glu  Leu Glu Glu Gly Phe  Ile Val Thr 
    3860                 3865                 3870             


Ile Thr  Glu Val Asn Leu Val  Asn Ser Asp Phe Ser  Thr Gly Gln 
    3875                 3880                 3885             


Pro Ser  Val Arg Arg Pro Gly  Met Glu Ile Ala Glu  Ile Met Ile 
    3890                 3895                 3900             


Glu Glu  Asn Asp Asp Pro Arg  Gly Ile Phe Met Phe  His Val Thr 
    3905                 3910                 3915             


Arg Gly  Ala Gly Glu Val Ile  Thr Ala Tyr Glu Val  Pro Pro Pro 
    3920                 3925                 3930             


Leu Asn  Val Leu Gln Val Pro  Val Val Arg Leu Ala  Gly Ser Phe 
    3935                 3940                 3945             


Gly Ala  Val Asn Val Tyr Trp  Lys Ala Ser Pro Asp  Ser Ala Gly 
    3950                 3955                 3960             


Leu Glu  Asp Phe Lys Pro Ser  His Gly Ile Leu Glu  Phe Ala Asp 
    3965                 3970                 3975             


Lys Gln  Val Thr Ala Met Ile  Glu Ile Thr Ile Ile  Asp Asp Ala 
    3980                 3985                 3990             


Glu Phe  Glu Leu Thr Glu Thr  Phe Asn Ile Ser Leu  Ile Ser Val 
    3995                 4000                 4005             


Ala Gly  Gly Gly Arg Leu Gly  Asp Asp Val Val Val  Thr Val Val 
    4010                 4015                 4020             


Ile Pro  Gln Asn Asp Ser Pro  Phe Gly Val Phe Gly  Phe Glu Glu 
    4025                 4030                 4035             


Lys Thr  Val Met Ile Asp Glu  Ser Leu Ser Ser Asp  Asp Pro Asp 
    4040                 4045                 4050             


Ser Tyr  Val Thr Leu Thr Val  Val Arg Ser Pro Gly  Gly Lys Gly 
    4055                 4060                 4065             


Thr Val  Arg Leu Glu Trp Thr  Ile Asp Glu Lys Ala  Lys His Asn 
    4070                 4075                 4080             


Leu Ser  Pro Leu Asn Gly Thr  Leu His Phe Asp Glu  Thr Glu Ser 
    4085                 4090                 4095             


Gln Lys  Thr Ile Val Leu His  Thr Leu Gln Asp Thr  Val Leu Glu 
    4100                 4105                 4110             


Glu Asp  Arg Arg Phe Thr Ile  Gln Leu Ile Ser Ile  Asp Glu Val 
    4115                 4120                 4125             


Glu Ile  Ser Pro Val Lys Gly  Ser Ala Ser Ile Ile  Ile Arg Gly 
    4130                 4135                 4140             


Asp Lys  Arg Ala Ser Gly Glu  Val Gly Ile Ala Pro  Ser Ser Arg 
    4145                 4150                 4155             


His Ile  Leu Ile Gly Glu Pro  Ser Ala Lys Tyr Asn  Gly Thr Ala 
    4160                 4165                 4170             


Ile Ile  Ser Leu Val Arg Gly  Pro Gly Ile Leu Gly  Glu Val Thr 
    4175                 4180                 4185             


Val Phe  Trp Arg Ile Phe Pro  Pro Ser Val Gly Glu  Phe Ala Glu 
    4190                 4195                 4200             


Thr Ser  Gly Lys Leu Thr Met  Arg Asp Glu Gln Ser  Ala Val Ile 
    4205                 4210                 4215             


Val Val  Ile Gln Ala Leu Asn  Asp Asp Ile Pro Glu  Glu Lys Ser 
    4220                 4225                 4230             


Phe Tyr  Glu Phe Gln Leu Thr  Ala Val Ser Glu Gly  Gly Val Leu 
    4235                 4240                 4245             


Ser Glu  Ser Ser Ser Thr Ala  Asn Ile Thr Val Val  Ala Ser Asp 
    4250                 4255                 4260             


Ser Pro  Tyr Gly Arg Phe Ala  Phe Ser His Glu Gln  Leu Arg Val 
    4265                 4270                 4275             


Ser Glu  Ala Gln Arg Val Asn  Ile Thr Ile Ile Arg  Ser Ser Gly 
    4280                 4285                 4290             


Asp Phe  Gly His Val Arg Leu  Trp Tyr Lys Thr Met  Ser Gly Thr 
    4295                 4300                 4305             


Ala Glu  Ala Gly Leu Asp Phe  Val Pro Ala Ala Gly  Glu Leu Leu 
    4310                 4315                 4320             


Phe Glu  Ala Gly Glu Met Arg  Lys Ser Leu His Val  Glu Ile Leu 
    4325                 4330                 4335             


Asp Asp  Asp Tyr Pro Glu Gly  Pro Glu Glu Phe Ser  Leu Thr Ile 
    4340                 4345                 4350             


Thr Lys  Val Glu Leu Gln Gly  Arg Gly Tyr Asp Phe  Thr Ile Gln 
    4355                 4360                 4365             


Glu Asn  Gly Leu Gln Ile Asp  Gln Pro Pro Glu Ile  Gly Asn Ile 
    4370                 4375                 4380             


Ser Ile  Val Arg Ile Ile Ile  Met Lys Asn Asp Asn  Ala Glu Gly 
    4385                 4390                 4395             


Ile Ile  Glu Phe Asp Pro Lys  Tyr Thr Ala Phe Glu  Val Glu Glu 
    4400                 4405                 4410             


Asp Val  Gly Leu Ile Met Ile  Pro Val Val Arg Leu  His Gly Thr 
    4415                 4420                 4425             


Tyr Gly  Tyr Val Thr Ala Asp  Phe Ile Ser Gln Ser  Ser Ser Ala 
    4430                 4435                 4440             


Ser Pro  Gly Gly Val Asp Tyr  Ile Leu His Gly Ser  Thr Val Thr 
    4445                 4450                 4455             


Phe Gln  His Gly Gln Asn Leu  Ser Phe Ile Asn Ile  Ser Ile Ile 
    4460                 4465                 4470             


Asp Asp  Asn Glu Ser Glu Phe  Glu Glu Pro Ile Glu  Ile Leu Leu 
    4475                 4480                 4485             


Thr Gly  Ala Thr Gly Gly Ala  Val Leu Gly Arg His  Leu Val Ser 
    4490                 4495                 4500             


Arg Ile  Ile Ile Ala Lys Ser  Asp Ser Pro Phe Gly  Val Ile Arg 
    4505                 4510                 4515             


Phe Leu  Asn Gln Ser Lys Ile  Ser Ile Ala Asn Pro  Asn Ser Thr 
    4520                 4525                 4530             


Met Ile  Leu Ser Leu Val Leu  Glu Arg Thr Gly Gly  Leu Leu Gly 
    4535                 4540                 4545             


Glu Ile  Gln Val Asn Trp Glu  Thr Val Gly Pro Asn  Ser Gln Glu 
    4550                 4555                 4560             


Ala Leu  Leu Pro Gln Asn Arg  Asp Ile Ala Asp Pro  Val Ser Gly 
    4565                 4570                 4575             


Leu Phe  Tyr Phe Gly Glu Gly  Glu Gly Gly Val Arg  Thr Ile Ile 
    4580                 4585                 4590             


Leu Thr  Ile Tyr Pro His Glu  Glu Ile Glu Val Glu  Glu Thr Phe 
    4595                 4600                 4605             


Ile Ile  Lys Leu His Leu Val  Lys Gly Glu Ala Lys  Leu Asp Ser 
    4610                 4615                 4620             


Arg Ala  Lys Asp Val Thr Leu  Thr Ile Gln Glu Phe  Gly Asp Pro 
    4625                 4630                 4635             


Asn Gly  Val Val Gln Phe Ala  Pro Glu Thr Leu Ser  Lys Lys Thr 
    4640                 4645                 4650             


Tyr Ser  Glu Pro Leu Ala Leu  Glu Gly Pro Leu Leu  Ile Thr Phe 
    4655                 4660                 4665             


Phe Val  Arg Arg Val Lys Gly  Thr Phe Gly Glu Ile  Met Val Tyr 
    4670                 4675                 4680             


Trp Glu  Leu Ser Ser Glu Phe  Asp Ile Thr Glu Asp  Phe Leu Ser 
    4685                 4690                 4695             


Thr Ser  Gly Phe Phe Thr Ile  Ala Asp Gly Glu Ser  Glu Ala Ser 
    4700                 4705                 4710             


Phe Asp  Val His Leu Leu Pro  Asp Glu Val Pro Glu  Ile Glu Glu 
    4715                 4720                 4725             


Asp Tyr  Val Ile Gln Leu Val  Ser Val Glu Gly Gly  Ala Glu Leu 
    4730                 4735                 4740             


Asp Leu  Glu Lys Ser Ile Thr  Trp Phe Ser Val Tyr  Ala Asn Asp 
    4745                 4750                 4755             


Asp Pro  His Gly Val Phe Ala  Leu Tyr Ser Asp Arg  Gln Ser Ile 
    4760                 4765                 4770             


Leu Ile  Gly Gln Asn Leu Ile  Arg Ser Ile Gln Ile  Asn Ile Thr 
    4775                 4780                 4785             


Arg Leu  Ala Gly Thr Phe Gly  Asp Val Ala Val Gly  Leu Arg Ile 
    4790                 4795                 4800             


Ser Ser  Asp His Lys Glu Gln  Pro Ile Val Thr Glu  Asn Ala Glu 
    4805                 4810                 4815             


Arg Gln  Leu Val Val Lys Asp  Gly Ala Thr Tyr Lys  Val Asp Val 
    4820                 4825                 4830             


Val Pro  Ile Lys Asn Gln Val  Phe Leu Ser Leu Gly  Ser Asn Phe 
    4835                 4840                 4845             


Thr Leu  Gln Leu Val Thr Val  Met Leu Val Gly Gly  Arg Phe Tyr 
    4850                 4855                 4860             


Gly Met  Pro Thr Ile Leu Gln  Glu Ala Lys Ser Ala  Val Leu Pro 
    4865                 4870                 4875             


Val Ser  Glu Lys Ala Ala Asn  Ser Gln Val Gly Phe  Glu Ser Thr 
    4880                 4885                 4890             


Ala Phe  Gln Leu Met Asn Ile  Thr Ala Gly Thr Ser  His Val Met 
    4895                 4900                 4905             


Ile Ser  Arg Arg Gly Thr Tyr  Gly Ala Leu Ser Val  Ala Trp Thr 
    4910                 4915                 4920             


Thr Gly  Tyr Ala Pro Gly Leu  Glu Ile Pro Glu Phe  Ile Val Val 
    4925                 4930                 4935             


Gly Asn  Met Thr Pro Thr Leu  Gly Ser Leu Ser Phe  Ser His Gly 
    4940                 4945                 4950             


Glu Gln  Arg Lys Gly Val Phe  Leu Trp Thr Phe Pro  Ser Pro Gly 
    4955                 4960                 4965             


Trp Pro  Glu Ala Phe Val Leu  His Leu Ser Gly Val  Gln Ser Ser 
    4970                 4975                 4980             


Ala Pro  Gly Gly Ala Gln Leu  Arg Ser Gly Phe Ile  Val Ala Glu 
    4985                 4990                 4995             


Ile Glu  Pro Met Gly Val Phe  Gln Phe Ser Thr Ser  Ser Arg Asn 
    5000                 5005                 5010             


Ile Ile  Val Ser Glu Asp Thr  Gln Met Ile Arg Leu  His Val Gln 
    5015                 5020                 5025             


Arg Leu  Phe Gly Phe His Ser  Asp Leu Ile Lys Val  Ser Tyr Gln 
    5030                 5035                 5040             


Thr Thr  Ala Gly Ser Ala Lys  Pro Leu Glu Asp Phe  Glu Pro Val 
    5045                 5050                 5055             


Gln Asn  Gly Glu Leu Phe Phe  Gln Lys Phe Gln Thr  Glu Val Asp 
    5060                 5065                 5070             


Phe Glu  Ile Thr Ile Ile Asn  Asp Gln Leu Ser Glu  Ile Glu Glu 
    5075                 5080                 5085             


Phe Phe  Tyr Ile Asn Leu Thr  Ser Val Glu Ile Arg  Gly Leu Gln 
    5090                 5095                 5100             


Lys Phe  Asp Val Asn Trp Ser  Pro Arg Leu Asn Leu  Asp Phe Ser 
    5105                 5110                 5115             


Val Ala  Val Ile Thr Ile Leu  Asp Asn Asp Asp Leu  Ala Gly Met 
    5120                 5125                 5130             


Asp Ile  Ser Phe Pro Glu Thr  Thr Val Ala Val Ala  Val Asp Thr 
    5135                 5140                 5145             


Thr Leu  Ile Pro Val Glu Thr  Glu Ser Thr Thr Tyr  Leu Ser Thr 
    5150                 5155                 5160             


Ser Lys  Thr Thr Thr Ile Leu  Gln Pro Thr Asn Val  Val Ala Ile 
    5165                 5170                 5175             


Val Thr  Glu Ala Thr Gly Val  Ser Ala Ile Pro Glu  Lys Leu Val 
    5180                 5185                 5190             


Thr Leu  His Gly Thr Pro Ala  Val Ser Glu Lys Pro  Asp Val Ala 
    5195                 5200                 5205             


Thr Val  Thr Ala Asn Val Ser  Ile His Gly Thr Phe  Ser Leu Gly 
    5210                 5215                 5220             


Pro Ser  Ile Val Tyr Ile Glu  Glu Glu Met Lys Asn  Gly Thr Phe 
    5225                 5230                 5235             


Asn Thr  Ala Glu Val Leu Ile  Arg Arg Thr Gly Gly  Phe Thr Gly 
    5240                 5245                 5250             


Asn Val  Ser Ile Thr Val Lys  Thr Phe Gly Glu Arg  Cys Ala Gln 
    5255                 5260                 5265             


Met Glu  Pro Asn Ala Leu Pro  Phe Arg Gly Ile Tyr  Gly Ile Ser 
    5270                 5275                 5280             


Asn Leu  Thr Trp Ala Val Glu  Glu Glu Asp Phe Glu  Glu Gln Thr 
    5285                 5290                 5295             


Leu Thr  Leu Ile Phe Leu Asp  Gly Glu Arg Glu Arg  Lys Val Ser 
    5300                 5305                 5310             


Val Gln  Ile Leu Asp Asp Asp  Glu Pro Glu Gly Gln  Glu Phe Phe 
    5315                 5320                 5325             


Tyr Val  Phe Leu Thr Asn Pro  Gln Gly Gly Ala Gln  Ile Val Glu 
    5330                 5335                 5340             


Glu Lys  Asp Asp Thr Gly Phe  Ala Ala Phe Ala Met  Val Ile Ile 
    5345                 5350                 5355             


Thr Gly  Ser Asp Leu His Asn  Gly Ile Ile Gly Phe  Ser Glu Glu 
    5360                 5365                 5370             


Ser Gln  Ser Gly Leu Glu Leu  Arg Glu Gly Ala Val  Met Arg Arg 
    5375                 5380                 5385             


Leu His  Leu Ile Val Thr Arg  Gln Pro Asn Arg Ala  Phe Glu Asp 
    5390                 5395                 5400             


Val Lys  Val Phe Trp Arg Val  Thr Leu Asn Lys Thr  Val Val Val 
    5405                 5410                 5415             


Leu Gln  Lys Asp Gly Val Asn  Leu Val Glu Glu Leu  Gln Ser Val 
    5420                 5425                 5430             


Ser Gly  Thr Thr Thr Cys Thr  Met Gly Gln Thr Lys  Cys Phe Ile 
    5435                 5440                 5445             


Ser Ile  Glu Leu Lys Pro Glu  Lys Val Pro Gln Val  Glu Val Tyr 
    5450                 5455                 5460             


Phe Phe  Val Glu Leu Tyr Glu  Ala Thr Ala Gly Ala  Ala Ile Asn 
    5465                 5470                 5475             


Asn Ser  Ala Arg Phe Ala Gln  Ile Lys Ile Leu Glu  Ser Asp Glu 
    5480                 5485                 5490             


Ser Gln  Ser Leu Val Tyr Phe  Ser Val Gly Ser Arg  Leu Ala Val 
    5495                 5500                 5505             


Ala His  Lys Lys Ala Thr Leu  Ile Ser Leu Gln Val  Ala Arg Asp 
    5510                 5515                 5520             


Ser Gly  Thr Gly Leu Met Met  Ser Val Asn Phe Ser  Thr Gln Glu 
    5525                 5530                 5535             


Leu Arg  Ser Ala Glu Thr Ile  Gly Arg Thr Ile Ile  Ser Pro Ala 
    5540                 5545                 5550             


Ile Ser  Gly Lys Asp Phe Val  Ile Thr Glu Gly Thr  Leu Val Phe 
    5555                 5560                 5565             


Glu Pro  Gly Gln Arg Ser Thr  Val Leu Asp Val Ile  Leu Thr Pro 
    5570                 5575                 5580             


Glu Thr  Gly Ser Leu Asn Ser  Phe Pro Lys Arg Phe  Gln Ile Val 
    5585                 5590                 5595             


Leu Phe  Asp Pro Lys Gly Gly  Ala Arg Ile Asp Lys  Val Tyr Gly 
    5600                 5605                 5610             


Thr Ala  Asn Ile Thr Leu Val  Ser Asp Ala Asp Ser  Gln Ala Ile 
    5615                 5620                 5625             


Trp Gly  Leu Ala Asp Gln Leu  His Gln Pro Val Asn  Asp Asp Ile 
    5630                 5635                 5640             


Leu Asn  Arg Val Leu His Thr  Ile Ser Met Lys Val  Ala Thr Glu 
    5645                 5650                 5655             


Asn Thr  Asp Glu Gln Leu Ser  Ala Met Met His Leu  Ile Glu Lys 
    5660                 5665                 5670             


Ile Thr  Thr Glu Gly Lys Ile  Gln Ala Phe Ser Val  Ala Ser Arg 
    5675                 5680                 5685             


Thr Leu  Phe Tyr Glu Ile Leu  Cys Ser Leu Ile Asn  Pro Lys Arg 
    5690                 5695                 5700             


Lys Asp  Thr Arg Gly Phe Ser  His Phe Ala Glu Val  Thr Glu Asn 
    5705                 5710                 5715             


Phe Ala  Phe Ser Leu Leu Thr  Asn Val Thr Cys Gly  Ser Pro Gly 
    5720                 5725                 5730             


Glu Lys  Ser Lys Thr Ile Leu  Asp Ser Cys Pro Tyr  Leu Ser Ile 
    5735                 5740                 5745             


Leu Ala  Leu His Trp Tyr Pro  Gln Gln Ile Asn Gly  His Lys Phe 
    5750                 5755                 5760             


Glu Gly  Lys Glu Gly Asp Tyr  Ile Arg Ile Pro Glu  Arg Leu Leu 
    5765                 5770                 5775             


Asp Val  Gln Asp Ala Glu Ile  Met Ala Gly Lys Ser  Thr Cys Lys 
    5780                 5785                 5790             


Leu Val  Gln Phe Thr Glu Tyr  Ser Ser Gln Gln Trp  Phe Ile Ser 
    5795                 5800                 5805             


Gly Asn  Asn Leu Pro Thr Leu  Lys Asn Lys Val Leu  Ser Leu Ser 
    5810                 5815                 5820             


Val Lys  Gly Gln Ser Ser Gln  Leu Leu Thr Asn Asp  Asn Glu Val 
    5825                 5830                 5835             


Leu Tyr  Arg Ile Tyr Ala Ala  Glu Pro Arg Ile Ile  Pro Gln Thr 
    5840                 5845                 5850             


Ser Leu  Cys Leu Leu Trp Asn  Gln Ala Ala Ala Ser  Trp Leu Ser 
    5855                 5860                 5865             


Asp Ser  Gln Phe Cys Lys Val  Val Glu Glu Thr Ala  Asp Tyr Val 
    5870                 5875                 5880             


Glu Cys  Ala Cys Ser His Met  Ser Val Tyr Ala Val  Tyr Ala Arg 
    5885                 5890                 5895             


Thr Asp  Asn Leu Ser Ser Tyr  Asn Glu Ala Phe Phe  Thr Ser Gly 
    5900                 5905                 5910             


Phe Ile  Cys Ile Ser Gly Leu  Cys Leu Ala Val Leu  Ser His Ile 
    5915                 5920                 5925             


Phe Cys  Ala Arg Tyr Ser Met  Phe Ala Ala Lys Leu  Leu Thr His 
    5930                 5935                 5940             


Met Met  Ala Ala Ser Leu Gly  Thr Gln Ile Leu Phe  Leu Ala Ser 
    5945                 5950                 5955             


Ala Tyr  Ala Ser Pro Gln Leu  Ala Glu Glu Ser Cys  Ser Ala Met 
    5960                 5965                 5970             


Ala Ala  Val Thr His Tyr Leu  Tyr Leu Cys Gln Phe  Ser Trp Met 
    5975                 5980                 5985             


Leu Ile  Gln Ser Val Asn Phe  Trp Tyr Val Leu Val  Met Asn Asp 
    5990                 5995                 6000             


Glu His  Thr Glu Arg Arg Tyr  Leu Leu Phe Phe Leu  Leu Ser Trp 
    6005                 6010                 6015             


Gly Leu  Pro Ala Phe Val Val  Ile Leu Leu Ile Val  Ile Leu Lys 
    6020                 6025                 6030             


Gly Ile  Tyr His Gln Ser Met  Ser Gln Ile Tyr Gly  Leu Ile His 
    6035                 6040                 6045             


Gly Asp  Leu Cys Phe Ile Pro  Asn Val Tyr Ala Ala  Leu Phe Thr 
    6050                 6055                 6060             


Ala Ala  Leu Val Pro Leu Thr  Cys Leu Val Val Val  Phe Val Val 
    6065                 6070                 6075             


Phe Ile  His Ala Tyr Gln Val  Lys Pro Gln Trp Lys  Ala Tyr Asp 
    6080                 6085                 6090             


Asp Val  Phe Arg Gly Arg Thr  Asn Ala Ala Glu Ile  Pro Leu Ile 
    6095                 6100                 6105             


Leu Tyr  Leu Phe Ala Leu Ile  Ser Val Thr Trp Leu  Trp Gly Gly 
    6110                 6115                 6120             


Leu His  Met Ala Tyr Arg His  Phe Trp Met Leu Val  Leu Phe Val 
    6125                 6130                 6135             


Ile Phe  Asn Ser Leu Gln Gly  Leu Tyr Val Phe Met  Val Tyr Phe 
    6140                 6145                 6150             


Ile Leu  His Asn Gln Met Cys  Cys Pro Met Lys Ala  Ser Tyr Thr 
    6155                 6160                 6165             


Val Glu  Met Asn Gly His Pro  Gly Pro Ser Thr Ala  Phe Phe Thr 
    6170                 6175                 6180             


Pro Gly  Ser Gly Met Pro Pro  Ala Gly Gly Glu Ile  Ser Lys Ser 
    6185                 6190                 6195             


Thr Gln  Asn Leu Ile Gly Ala  Met Glu Glu Val Pro  Pro Asp Trp 
    6200                 6205                 6210             


Glu Arg  Ala Ser Phe Gln Gln  Gly Ser Gln Ala Ser  Pro Asp Leu 
    6215                 6220                 6225             


Lys Pro  Ser Pro Gln Asn Gly  Ala Thr Phe Pro Ser  Ser Gly Gly 
    6230                 6235                 6240             


Tyr Gly  Gln Gly Ser Leu Ile  Ala Asp Glu Glu Ser  Gln Glu Phe 
    6245                 6250                 6255             


Asp Asp  Leu Ile Phe Ala Leu  Lys Thr Gly Ala Gly  Leu Ser Val 
    6260                 6265                 6270             


Ser Asp  Asn Glu Ser Gly Gln  Gly Ser Gln Glu Gly  Gly Thr Leu 
    6275                 6280                 6285             


Thr Asp  Ser Gln Ile Val Glu  Leu Arg Arg Ile Pro  Ile Ala Asp 
    6290                 6295                 6300             


Thr His  Leu 
    6305     


<210>  22
<211>  201
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(201)
<223>  GUCA1A (guanylyl cyclase-activating protein 1)

<400>  22

Met Gly Asn Val Met Glu Gly Lys Ser Val Glu Glu Leu Ser Ser Thr 
1               5                   10                  15      


Glu Cys His Gln Trp Tyr Lys Lys Phe Met Thr Glu Cys Pro Ser Gly 
            20                  25                  30          


Gln Leu Thr Leu Tyr Glu Phe Arg Gln Phe Phe Gly Leu Lys Asn Leu 
        35                  40                  45              


Ser Pro Ser Ala Ser Gln Tyr Val Glu Gln Met Phe Glu Thr Phe Asp 
    50                  55                  60                  


Phe Asn Lys Asp Gly Tyr Ile Asp Phe Met Glu Tyr Val Ala Ala Leu 
65                  70                  75                  80  


Ser Leu Val Leu Lys Gly Lys Val Glu Gln Lys Leu Arg Trp Tyr Phe 
                85                  90                  95      


Lys Leu Tyr Asp Val Asp Gly Asn Gly Cys Ile Asp Arg Asp Glu Leu 
            100                 105                 110         


Leu Thr Ile Ile Gln Ala Ile Arg Ala Ile Asn Pro Cys Ser Asp Thr 
        115                 120                 125             


Thr Met Thr Ala Glu Glu Phe Thr Asp Thr Val Phe Ser Lys Ile Asp 
    130                 135                 140                 


Val Asn Gly Asp Gly Glu Leu Ser Leu Glu Glu Phe Ile Glu Gly Val 
145                 150                 155                 160 


Gln Lys Asp Gln Met Leu Leu Asp Thr Leu Thr Arg Ser Leu Asp Leu 
                165                 170                 175     


Thr Arg Ile Val Arg Arg Leu Gln Asn Gly Glu Gln Asp Glu Glu Gly 
            180                 185                 190         


Ala Asp Glu Ala Ala Glu Ala Ala Gly 
        195                 200     


<210>  23
<211>  200
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(200)
<223>  GUCA1B (guanylyl cyclase-activating protein 2)

<400>  23

Met Gly Gln Glu Phe Ser Trp Glu Glu Ala Glu Ala Ala Gly Glu Ile 
1               5                   10                  15      


Asp Val Ala Glu Leu Gln Glu Trp Tyr Lys Lys Phe Val Met Glu Cys 
            20                  25                  30          


Pro Ser Gly Thr Leu Phe Met His Glu Phe Lys Arg Phe Phe Lys Val 
        35                  40                  45              


Thr Asp Asp Glu Glu Ala Ser Gln Tyr Val Glu Gly Met Phe Arg Ala 
    50                  55                  60                  


Phe Asp Lys Asn Gly Asp Asn Thr Ile Asp Phe Leu Glu Tyr Val Ala 
65                  70                  75                  80  


Ala Leu Asn Leu Val Leu Arg Gly Thr Leu Glu His Lys Leu Lys Trp 
                85                  90                  95      


Thr Phe Lys Ile Tyr Asp Lys Asp Gly Asn Gly Cys Ile Asp Arg Leu 
            100                 105                 110         


Glu Leu Leu Asn Ile Val Glu Gly Ile Tyr Gln Leu Lys Lys Ala Cys 
        115                 120                 125             


Arg Arg Glu Leu Gln Thr Glu Gln Gly Gln Leu Leu Thr Pro Glu Glu 
    130                 135                 140                 


Val Val Asp Arg Ile Phe Leu Leu Val Asp Glu Asn Gly Asp Gly Gln 
145                 150                 155                 160 


Leu Ser Leu Asn Glu Phe Val Glu Gly Ala Arg Arg Asp Lys Trp Val 
                165                 170                 175     


Met Lys Met Leu Gln Met Asp Met Asn Pro Ser Ser Trp Leu Ala Gln 
            180                 185                 190         


Gln Arg Arg Lys Ser Ala Met Phe 
        195                 200 


<210>  24
<211>  2213
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(2213)
<223>  MYO7A (unconventional myosin-VIIa), isoform 1

<400>  24

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Glu Cys  Arg Val Trp Leu Ser  Leu Gly Cys 
    1520                 1525                 1530             


Ser Asp  Leu Gly Cys Ala Ala  Pro His Ser Gly Trp  Ala Gly Leu 
    1535                 1540                 1545             


Thr Pro  Ala Gly Pro Cys Ser  Pro Cys Trp Ser Cys  Arg Gly Ala 
    1550                 1555                 1560             


Lys Thr  Thr Ala Pro Ser Phe  Thr Leu Ala Thr Ile  Lys Gly Asp 
    1565                 1570                 1575             


Glu Tyr  Thr Phe Thr Ser Ser  Asn Ala Glu Asp Ile  Arg Asp Leu 
    1580                 1585                 1590             


Val Val  Thr Phe Leu Glu Gly  Leu Arg Lys Arg Ser  Lys Tyr Val 
    1595                 1600                 1605             


Val Ala  Leu Gln Asp Asn Pro  Asn Pro Ala Gly Glu  Glu Ser Gly 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ala Lys Gly  Asp Leu Ile Ile Leu  Asp His Asp 
    1625                 1630                 1635             


Thr Gly  Glu Gln Val Met Asn  Ser Gly Trp Ala Asn  Gly Ile Asn 
    1640                 1645                 1650             


Glu Arg  Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Ser Val Tyr 
    1655                 1660                 1665             


Val Met  Pro Thr Val Thr Met  Pro Pro Arg Glu Ile  Val Ala Leu 
    1670                 1675                 1680             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1685                 1690                 1695             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1700                 1705                 1710             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1715                 1720                 1725             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1730                 1735                 1740             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1745                 1750                 1755             


Lys Leu  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Leu Ala 
    1760                 1765                 1770             


Phe Ile  Ala Val Leu Lys Tyr  Met Gly Asp Tyr Pro  Ser Lys Arg 
    1775                 1780                 1785             


Thr Arg  Ser Val Asn Glu Leu  Thr Asp Gln Ile Phe  Glu Gly Pro 
    1790                 1795                 1800             


Leu Lys  Ala Glu Pro Leu Lys  Asp Glu Ala Tyr Val  Gln Ile Leu 
    1805                 1810                 1815             


Lys Gln  Leu Thr Asp Asn His  Ile Arg Tyr Ser Glu  Glu Arg Gly 
    1820                 1825                 1830             


Trp Glu  Leu Leu Trp Leu Cys  Thr Gly Leu Phe Pro  Pro Ser Asn 
    1835                 1840                 1845             


Ile Leu  Leu Pro His Val Gln  Arg Phe Leu Gln Ser  Arg Lys His 
    1850                 1855                 1860             


Cys Pro  Leu Ala Ile Asp Cys  Leu Gln Arg Leu Gln  Lys Ala Leu 
    1865                 1870                 1875             


Arg Asn  Gly Ser Arg Lys Tyr  Pro Pro His Leu Val  Glu Val Glu 
    1880                 1885                 1890             


Ala Ile  Gln His Lys Thr Thr  Gln Ile Phe His Lys  Val Tyr Phe 
    1895                 1900                 1905             


Pro Asp  Asp Thr Asp Glu Ala  Phe Glu Val Glu Ser  Ser Thr Lys 
    1910                 1915                 1920             


Ala Lys  Asp Phe Cys Gln Asn  Ile Ala Thr Arg Leu  Leu Leu Lys 
    1925                 1930                 1935             


Ser Ser  Glu Gly Phe Ser Leu  Phe Val Lys Ile Ala  Asp Lys Val 
    1940                 1945                 1950             


Leu Ser  Val Pro Glu Asn Asp  Phe Phe Phe Asp Phe  Val Arg His 
    1955                 1960                 1965             


Leu Thr  Asp Trp Ile Lys Lys  Ala Arg Pro Ile Lys  Asp Gly Ile 
    1970                 1975                 1980             


Val Pro  Ser Leu Thr Tyr Gln  Val Phe Phe Met Lys  Lys Leu Trp 
    1985                 1990                 1995             


Thr Thr  Thr Val Pro Gly Lys  Asp Pro Met Ala Asp  Ser Ile Phe 
    2000                 2005                 2010             


His Tyr  Tyr Gln Glu Leu Pro  Lys Tyr Leu Arg Gly  Tyr His Lys 
    2015                 2020                 2025             


Cys Thr  Arg Glu Glu Val Leu  Gln Leu Gly Ala Leu  Ile Tyr Arg 
    2030                 2035                 2040             


Val Lys  Phe Glu Glu Asp Lys  Ser Tyr Phe Pro Ser  Ile Pro Lys 
    2045                 2050                 2055             


Leu Leu  Arg Glu Leu Val Pro  Gln Asp Leu Ile Arg  Gln Val Ser 
    2060                 2065                 2070             


Pro Asp  Asp Trp Lys Arg Ser  Ile Val Ala Tyr Phe  Asn Lys His 
    2075                 2080                 2085             


Ala Gly  Lys Ser Lys Glu Glu  Ala Lys Leu Ala Phe  Leu Lys Leu 
    2090                 2095                 2100             


Ile Phe  Lys Trp Pro Thr Phe  Gly Ser Ala Phe Phe  Glu Val Lys 
    2105                 2110                 2115             


Gln Thr  Thr Glu Pro Asn Phe  Pro Glu Ile Leu Leu  Ile Ala Ile 
    2120                 2125                 2130             


Asn Lys  Tyr Gly Val Ser Leu  Ile Asp Pro Lys Thr  Lys Asp Ile 
    2135                 2140                 2145             


Leu Thr  Thr His Pro Phe Thr  Lys Ile Ser Asn Trp  Ser Ser Gly 
    2150                 2155                 2160             


Asn Thr  Tyr Phe His Ile Thr  Ile Gly Asn Leu Val  Arg Gly Ser 
    2165                 2170                 2175             


Lys Leu  Leu Cys Glu Thr Ser  Leu Gly Tyr Lys Met  Asp Asp Leu 
    2180                 2185                 2190             


Leu Thr  Ser Tyr Ile Ser Gln  Met Leu Thr Ala Met  Ser Lys Gln 
    2195                 2200                 2205             


Arg Gly  Ser Arg Ser 
    2210             


<210>  25
<211>  236
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(237)
<223>  NRL (neural retina-specific leucine zipper protein), isoform 1

<400>  25

Ala Leu Pro Pro Ser Pro Leu Ala Met Glu Tyr Val Asn Asp Phe Asp 
1               5                   10                  15      


Leu Met Lys Phe Glu Val Lys Arg Glu Pro Ser Glu Gly Arg Pro Gly 
            20                  25                  30          


Pro Pro Thr Ala Ser Leu Gly Ser Thr Pro Tyr Ser Ser Val Pro Pro 
        35                  40                  45              


Ser Pro Thr Phe Ser Glu Pro Gly Met Val Gly Ala Thr Glu Gly Thr 
    50                  55                  60                  


Arg Pro Gly Leu Glu Glu Leu Tyr Trp Leu Ala Thr Leu Gln Gln Gln 
65                  70                  75                  80  


Leu Gly Ala Gly Glu Ala Leu Gly Leu Ser Pro Glu Glu Ala Met Glu 
                85                  90                  95      


Leu Leu Gln Gly Gln Gly Pro Val Pro Val Asp Gly Pro His Gly Tyr 
            100                 105                 110         


Tyr Pro Gly Ser Pro Glu Glu Thr Gly Ala Gln His Val Gln Leu Ala 
        115                 120                 125             


Glu Arg Phe Ser Asp Ala Ala Leu Val Ser Met Ser Val Arg Glu Leu 
    130                 135                 140                 


Asn Arg Gln Leu Arg Gly Cys Gly Arg Asp Glu Ala Leu Arg Leu Lys 
145                 150                 155                 160 


Gln Arg Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ala Cys Arg 
                165                 170                 175     


Ser Lys Arg Leu Gln Gln Arg Arg Gly Leu Glu Ala Glu Arg Ala Arg 
            180                 185                 190         


Leu Ala Ala Gln Leu Asp Ala Leu Arg Ala Glu Val Ala Arg Leu Ala 
        195                 200                 205             


Arg Glu Arg Asp Leu Tyr Lys Ala Arg Cys Asp Arg Leu Thr Ser Ser 
    210                 215                 220                 


Gly Pro Gly Ser Gly Asp Pro Ser His Leu Phe Leu 
225                 230                 235     


<210>  26
<211>  860
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(860)
<223>  PDE6A (rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit 
       alpha)

<400>  26

Met Gly Glu Val Thr Ala Glu Glu Val Glu Lys Phe Leu Asp Ser Asn 
1               5                   10                  15      


Ile Gly Phe Ala Lys Gln Tyr Tyr Asn Leu His Tyr Arg Ala Lys Leu 
            20                  25                  30          


Ile Ser Asp Leu Leu Gly Ala Lys Glu Ala Ala Val Asp Phe Ser Asn 
        35                  40                  45              


Tyr His Ser Pro Ser Ser Met Glu Glu Ser Glu Ile Ile Phe Asp Leu 
    50                  55                  60                  


Leu Arg Asp Phe Gln Glu Asn Leu Gln Thr Glu Lys Cys Ile Phe Asn 
65                  70                  75                  80  


Val Met Lys Lys Leu Cys Phe Leu Leu Gln Ala Asp Arg Met Ser Leu 
                85                  90                  95      


Phe Met Tyr Arg Thr Arg Asn Gly Ile Ala Glu Leu Ala Thr Arg Leu 
            100                 105                 110         


Phe Asn Val His Lys Asp Ala Val Leu Glu Asp Cys Leu Val Met Pro 
        115                 120                 125             


Asp Gln Glu Ile Val Phe Pro Leu Asp Met Gly Ile Val Gly His Val 
    130                 135                 140                 


Ala His Ser Lys Lys Ile Ala Asn Val Pro Asn Thr Glu Glu Asp Glu 
145                 150                 155                 160 


His Phe Cys Asp Phe Val Asp Ile Leu Thr Glu Tyr Lys Thr Lys Asn 
                165                 170                 175     


Ile Leu Ala Ser Pro Ile Met Asn Gly Lys Asp Val Val Ala Ile Ile 
            180                 185                 190         


Met Ala Val Asn Lys Val Asp Gly Ser His Phe Thr Lys Arg Asp Glu 
        195                 200                 205             


Glu Ile Leu Leu Lys Tyr Leu Asn Phe Ala Asn Leu Ile Met Lys Val 
    210                 215                 220                 


Tyr His Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Ile 
225                 230                 235                 240 


Leu Leu Trp Ser Gly Ser Lys Val Phe Glu Glu Leu Thr Asp Ile Glu 
                245                 250                 255     


Arg Gln Phe His Lys Ala Leu Tyr Thr Val Arg Ala Phe Leu Asn Cys 
            260                 265                 270         


Asp Arg Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Gln Lys Glu Phe 
        275                 280                 285             


Phe Asp Val Trp Pro Val Leu Met Gly Glu Val Pro Pro Tyr Ser Gly 
    290                 295                 300                 


Pro Arg Thr Pro Asp Gly Arg Glu Ile Asn Phe Tyr Lys Val Ile Asp 
305                 310                 315                 320 


Tyr Ile Leu His Gly Lys Glu Asp Ile Lys Val Ile Pro Asn Pro Pro 
                325                 330                 335     


Pro Asp His Trp Ala Leu Val Ser Gly Leu Pro Ala Tyr Val Ala Gln 
            340                 345                 350         


Asn Gly Leu Ile Cys Asn Ile Met Asn Ala Pro Ala Glu Asp Phe Phe 
        355                 360                 365             


Ala Phe Gln Lys Glu Pro Leu Asp Glu Ser Gly Trp Met Ile Lys Asn 
    370                 375                 380                 


Val Leu Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val 
385                 390                 395                 400 


Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Met Asp 
                405                 410                 415     


Glu Thr Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Leu 
            420                 425                 430         


Asn Pro Asp Thr Tyr Glu Ser Met Asn Lys Leu Glu Asn Arg Lys Asp 
        435                 440                 445             


Ile Phe Gln Asp Ile Val Lys Tyr His Val Lys Cys Asp Asn Glu Glu 
    450                 455                 460                 


Ile Gln Lys Ile Leu Lys Thr Arg Glu Val Tyr Gly Lys Glu Pro Trp 
465                 470                 475                 480 


Glu Cys Glu Glu Glu Glu Leu Ala Glu Ile Leu Gln Ala Glu Leu Pro 
                485                 490                 495     


Asp Ala Asp Lys Tyr Glu Ile Asn Lys Phe His Phe Ser Asp Leu Pro 
            500                 505                 510         


Leu Thr Glu Leu Glu Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu 
        515                 520                 525             


Leu Lys Val Val Asp Lys Phe His Ile Pro Gln Glu Ala Leu Val Arg 
    530                 535                 540                 


Phe Met Tyr Ser Leu Ser Lys Gly Tyr Arg Lys Ile Thr Tyr His Asn 
545                 550                 555                 560 


Trp Arg His Gly Phe Asn Val Gly Gln Thr Met Phe Ser Leu Leu Val 
                565                 570                 575     


Thr Gly Lys Leu Lys Arg Tyr Phe Thr Asp Leu Glu Ala Leu Ala Met 
            580                 585                 590         


Val Thr Ala Ala Phe Cys His Asp Ile Asp His Arg Gly Thr Asn Asn 
        595                 600                 605             


Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser 
    610                 615                 620                 


Ser Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Thr Leu Leu Arg 
625                 630                 635                 640 


Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Arg Arg Gln His Glu 
                645                 650                 655     


His Ala Ile His Met Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala 
            660                 665                 670         


Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val Asp Gln Ser 
        675                 680                 685             


Lys Thr Tyr Glu Ser Glu Gln Glu Trp Thr Gln Tyr Met Met Leu Glu 
    690                 695                 700                 


Gln Thr Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp 
705                 710                 715                 720 


Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Gln Val Ala Leu 
                725                 730                 735     


Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val 
            740                 745                 750         


Leu Gln Gln Asn Pro Ile Pro Met Met Asp Arg Asn Lys Ala Asp Glu 
        755                 760                 765             


Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val 
    770                 775                 780                 


Tyr Lys Glu Phe Ser Arg Phe His Glu Glu Ile Thr Pro Met Leu Asp 
785                 790                 795                 800 


Gly Ile Thr Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr 
                805                 810                 815     


Asp Ala Lys Met Lys Val Gln Glu Glu Lys Lys Gln Lys Gln Gln Ser 
            820                 825                 830         


Ala Lys Ser Ala Ala Ala Gly Asn Gln Pro Gly Gly Asn Pro Ser Pro 
        835                 840                 845             


Gly Gly Ala Thr Thr Ser Lys Ser Cys Cys Ile Gln 
    850                 855                 860 


<210>  27
<211>  854
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(854)
<223>  PDE6B (rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit 
       beta), isoform 1

<400>  27

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Val 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Ile Cys Asn Ile Met Asn Ala Ser Ala Asp Glu Met Phe Lys Phe 
        355                 360                 365             


Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys Asn Val Leu 
    370                 375                 380                 


Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val Ala Thr 
385                 390                 395                 400 


Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln Asp Glu Val 
                405                 410                 415     


Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Met Asn Thr 
            420                 425                 430         


Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys Asp Ile Ala 
        435                 440                 445             


Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp Glu Ile Gln 
    450                 455                 460                 


Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro Ala Asp Cys 
465                 470                 475                 480 


Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu Pro Gly Pro 
                485                 490                 495     


Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu Glu Cys Thr 
            500                 505                 510         


Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu Leu Gly 
        515                 520                 525             


Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val Arg Phe Leu 
    530                 535                 540                 


Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His Asn Trp Arg 
545                 550                 555                 560 


His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu Met Thr Gly 
                565                 570                 575     


Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala Met Val Thr 
            580                 585                 590         


Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 
        595                 600                 605             


Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser Ile 
    610                 615                 620                 


Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu Ser Glu Glu 
625                 630                 635                 640 


Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His Glu His Val 
                645                 650                 655     


Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
            660                 665                 670         


Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu Ser Lys Asn 
        675                 680                 685             


Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu Glu Thr Thr 
    690                 695                 700                 


Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp Leu Ser 
705                 710                 715                 720 


Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala Leu Leu Val 
                725                 730                 735     


Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val Leu Asp 
            740                 745                 750         


Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala Glu Leu Pro 
        755                 760                 765             


Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys 
    770                 775                 780                 


Glu Phe Ser Arg Phe His Glu Glu Ile Leu Pro Met Phe Asp Arg Leu 
785                 790                 795                 800 


Gln Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr Glu Ala 
                805                 810                 815     


Lys Val Lys Ala Leu Glu Glu Lys Glu Glu Glu Glu Arg Val Ala Ala 
            820                 825                 830         


Lys Lys Val Gly Thr Glu Ile Cys Asn Gly Gly Pro Ala Pro Lys Ser 
        835                 840                 845             


Ser Thr Cys Cys Ile Leu 
    850                 


<210>  28
<211>  346
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(346)
<223>  PRPH2 (peripherin-2)

<400>  28

Met Ala Leu Leu Lys Val Lys Phe Asp Gln Lys Lys Arg Val Lys Leu 
1               5                   10                  15      


Ala Gln Gly Leu Trp Leu Met Asn Trp Phe Ser Val Leu Ala Gly Ile 
            20                  25                  30          


Ile Ile Phe Ser Leu Gly Leu Phe Leu Lys Ile Glu Leu Arg Lys Arg 
        35                  40                  45              


Ser Asp Val Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu 
    50                  55                  60                  


Ile Gly Met Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala Gly Lys 
65                  70                  75                  80  


Ile Cys Tyr Asp Ala Leu Asp Pro Ala Lys Tyr Ala Arg Trp Lys Pro 
                85                  90                  95      


Trp Leu Lys Pro Tyr Leu Ala Ile Cys Val Leu Phe Asn Ile Ile Leu 
            100                 105                 110         


Phe Leu Val Ala Leu Cys Cys Phe Leu Leu Arg Gly Ser Leu Glu Asn 
        115                 120                 125             


Thr Leu Gly Gln Gly Leu Lys Asn Gly Met Lys Tyr Tyr Arg Asp Thr 
    130                 135                 140                 


Asp Thr Pro Gly Arg Cys Phe Met Lys Lys Thr Ile Asp Met Leu Gln 
145                 150                 155                 160 


Ile Glu Phe Lys Cys Cys Gly Asn Asn Gly Phe Arg Asp Trp Phe Glu 
                165                 170                 175     


Ile Gln Trp Ile Ser Asn Arg Tyr Leu Asp Phe Ser Ser Lys Glu Val 
            180                 185                 190         


Lys Asp Arg Ile Lys Ser Asn Val Asp Gly Arg Tyr Leu Val Asp Gly 
        195                 200                 205             


Val Pro Phe Ser Cys Cys Asn Pro Ser Ser Pro Arg Pro Cys Ile Gln 
    210                 215                 220                 


Tyr Gln Ile Thr Asn Asn Ser Ala His Tyr Ser Tyr Asp His Gln Thr 
225                 230                 235                 240 


Glu Glu Leu Asn Leu Trp Val Arg Gly Cys Arg Ala Ala Leu Leu Ser 
                245                 250                 255     


Tyr Tyr Ser Ser Leu Met Asn Ser Met Gly Val Val Thr Leu Leu Ile 
            260                 265                 270         


Trp Leu Phe Glu Val Thr Ile Thr Ile Gly Leu Arg Tyr Leu Gln Thr 
        275                 280                 285             


Ser Leu Asp Gly Val Ser Asn Pro Glu Glu Ser Glu Ser Glu Ser Glu 
    290                 295                 300                 


Gly Trp Leu Leu Glu Lys Ser Val Pro Glu Thr Trp Lys Ala Phe Leu 
305                 310                 315                 320 


Glu Ser Val Lys Lys Leu Gly Lys Gly Asn Gln Val Glu Ala Glu Gly 
                325                 330                 335     


Ala Gly Ala Gly Gln Ala Pro Glu Ala Gly 
            340                 345     


<210>  29
<211>  865
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(865)
<223>  PROM1 (prominin-1), isoform 1

<400>  29

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  30
<211>  348
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(348)
<223>  RHO

<400>  30

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  31
<211>  351
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(351)
<223>  ROM1 (rod outer segment membrane protein 1)

<400>  31

Met Ala Pro Val Leu Pro Leu Val Leu Pro Leu Gln Pro Arg Ile Arg 
1               5                   10                  15      


Leu Ala Gln Gly Leu Trp Leu Leu Ser Trp Leu Leu Ala Leu Ala Gly 
            20                  25                  30          


Gly Val Ile Leu Leu Cys Ser Gly His Leu Leu Val Gln Leu Arg His 
        35                  40                  45              


Leu Gly Thr Phe Leu Ala Pro Ser Cys Gln Phe Pro Val Leu Pro Gln 
    50                  55                  60                  


Ala Ala Leu Ala Ala Gly Ala Val Ala Leu Gly Thr Gly Leu Val Gly 
65                  70                  75                  80  


Val Gly Ala Ser Arg Ala Ser Leu Asn Ala Ala Leu Tyr Pro Pro Trp 
                85                  90                  95      


Arg Gly Val Leu Gly Pro Leu Leu Val Ala Gly Thr Ala Gly Gly Gly 
            100                 105                 110         


Gly Leu Leu Val Val Gly Leu Gly Leu Ala Leu Ala Leu Pro Gly Ser 
        115                 120                 125             


Leu Asp Glu Ala Leu Glu Glu Gly Leu Val Thr Ala Leu Ala His Tyr 
    130                 135                 140                 


Lys Asp Thr Glu Val Pro Gly His Cys Gln Ala Lys Arg Leu Val Asp 
145                 150                 155                 160 


Glu Leu Gln Leu Arg Tyr His Cys Cys Gly Arg His Gly Tyr Lys Asp 
                165                 170                 175     


Trp Phe Gly Val Gln Trp Val Ser Ser Arg Tyr Leu Asp Pro Gly Asp 
            180                 185                 190         


Arg Asp Val Ala Asp Arg Ile Gln Ser Asn Val Glu Gly Leu Tyr Leu 
        195                 200                 205             


Thr Asp Gly Val Pro Phe Ser Cys Cys Asn Pro His Ser Pro Arg Pro 
    210                 215                 220                 


Cys Leu Gln Asn Arg Leu Ser Asp Ser Tyr Ala His Pro Leu Phe Asp 
225                 230                 235                 240 


Pro Arg Gln Pro Asn Gln Asn Leu Trp Ala Gln Gly Cys His Glu Val 
                245                 250                 255     


Leu Leu Glu His Leu Gln Asp Leu Ala Gly Thr Leu Gly Ser Met Leu 
            260                 265                 270         


Ala Val Thr Phe Leu Leu Gln Ala Leu Val Leu Leu Gly Leu Arg Tyr 
        275                 280                 285             


Leu Gln Thr Ala Leu Glu Gly Leu Gly Gly Val Ile Asp Ala Gly Gly 
    290                 295                 300                 


Glu Thr Gln Gly Tyr Leu Phe Pro Ser Gly Leu Lys Asp Met Leu Lys 
305                 310                 315                 320 


Thr Ala Trp Leu Gln Gly Gly Val Ala Cys Arg Pro Ala Pro Glu Glu 
                325                 330                 335     


Ala Pro Pro Gly Glu Ala Pro Pro Lys Glu Asp Leu Ser Glu Ala 
            340                 345                 350     


<210>  32
<211>  2156
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(2156)
<223>  RP1 (oxygen-regulated protein 1)

<400>  32

Met Ser Asp Thr Pro Ser Thr Gly Phe Ser Ile Ile His Pro Thr Ser 
1               5                   10                  15      


Ser Glu Gly Gln Val Pro Pro Pro Arg His Leu Ser Leu Thr His Pro 
            20                  25                  30          


Val Val Ala Lys Arg Ile Ser Phe Tyr Lys Ser Gly Asp Pro Gln Phe 
        35                  40                  45              


Gly Gly Val Arg Val Val Val Asn Pro Arg Ser Phe Lys Ser Phe Asp 
    50                  55                  60                  


Ala Leu Leu Asp Asn Leu Ser Arg Lys Val Pro Leu Pro Phe Gly Val 
65                  70                  75                  80  


Arg Asn Ile Ser Thr Pro Arg Gly Arg His Ser Ile Thr Arg Leu Glu 
                85                  90                  95      


Glu Leu Glu Asp Gly Glu Ser Tyr Leu Cys Ser His Gly Arg Lys Val 
            100                 105                 110         


Gln Pro Val Asp Leu Asp Lys Ala Arg Arg Arg Pro Arg Pro Trp Leu 
        115                 120                 125             


Ser Ser Arg Ala Ile Ser Ala His Ser Pro Pro His Pro Val Ala Val 
    130                 135                 140                 


Ala Ala Pro Gly Met Pro Arg Pro Pro Arg Ser Leu Val Val Phe Arg 
145                 150                 155                 160 


Asn Gly Asp Pro Lys Thr Arg Arg Ala Val Leu Leu Ser Arg Arg Val 
                165                 170                 175     


Thr Gln Ser Phe Glu Ala Phe Leu Gln His Leu Thr Glu Val Met Gln 
            180                 185                 190         


Arg Pro Val Val Lys Leu Tyr Ala Thr Asp Gly Arg Arg Val Pro Ser 
        195                 200                 205             


Leu Gln Ala Val Ile Leu Ser Ser Gly Ala Val Val Ala Ala Gly Arg 
    210                 215                 220                 


Glu Pro Phe Lys Pro Gly Asn Tyr Asp Ile Gln Lys Tyr Leu Leu Pro 
225                 230                 235                 240 


Ala Arg Leu Pro Gly Ile Ser Gln Arg Val Tyr Pro Lys Gly Asn Ala 
                245                 250                 255     


Lys Ser Glu Ser Arg Lys Ile Ser Thr His Met Ser Ser Ser Ser Arg 
            260                 265                 270         


Ser Gln Ile Tyr Ser Val Ser Ser Glu Lys Thr His Asn Asn Asp Cys 
        275                 280                 285             


Tyr Leu Asp Tyr Ser Phe Val Pro Glu Lys Tyr Leu Ala Leu Glu Lys 
    290                 295                 300                 


Asn Asp Ser Gln Asn Leu Pro Ile Tyr Pro Ser Glu Asp Asp Ile Glu 
305                 310                 315                 320 


Lys Ser Ile Ile Phe Asn Gln Asp Gly Thr Met Thr Val Glu Met Lys 
                325                 330                 335     


Val Arg Phe Arg Ile Lys Glu Glu Glu Thr Ile Lys Trp Thr Thr Thr 
            340                 345                 350         


Val Ser Lys Thr Gly Pro Ser Asn Asn Asp Glu Lys Ser Glu Met Ser 
        355                 360                 365             


Phe Pro Gly Arg Thr Glu Ser Arg Ser Ser Gly Leu Lys Leu Ala Ala 
    370                 375                 380                 


Cys Ser Phe Ser Ala Asp Val Ser Pro Met Glu Arg Ser Ser Asn Gln 
385                 390                 395                 400 


Glu Gly Ser Leu Ala Glu Glu Ile Asn Ile Gln Met Thr Asp Gln Val 
                405                 410                 415     


Ala Glu Thr Cys Ser Ser Ala Ser Trp Glu Asn Ala Thr Val Asp Thr 
            420                 425                 430         


Asp Ile Ile Gln Gly Thr Gln Asp Gln Ala Lys His Arg Phe Tyr Arg 
        435                 440                 445             


Pro Pro Thr Pro Gly Leu Arg Arg Val Arg Gln Lys Lys Ser Val Ile 
    450                 455                 460                 


Gly Ser Val Thr Leu Val Ser Glu Thr Glu Val Gln Glu Lys Met Ile 
465                 470                 475                 480 


Gly Gln Phe Ser Tyr Ser Glu Glu Arg Glu Ser Gly Glu Asn Lys Ser 
                485                 490                 495     


Glu Tyr His Met Phe Thr His Ser Cys Ser Lys Met Ser Ser Val Ser 
            500                 505                 510         


Asn Lys Pro Val Leu Val Gln Ile Asn Asn Asn Asp Gln Met Glu Glu 
        515                 520                 525             


Ser Ser Leu Glu Arg Lys Lys Glu Asn Ser Leu Leu Lys Ser Ser Ala 
    530                 535                 540                 


Ile Ser Ala Gly Val Ile Glu Ile Thr Ser Gln Lys Met Leu Glu Met 
545                 550                 555                 560 


Ser His Asn Asn Gly Leu Pro Ser Thr Ile Ser Asn Asn Ser Ile Val 
                565                 570                 575     


Glu Glu Asp Val Val Asp Cys Val Val Leu Asp Asn Lys Thr Gly Ile 
            580                 585                 590         


Lys Asn Phe Lys Thr Tyr Gly Asn Thr Asn Asp Arg Phe Ser Pro Ile 
        595                 600                 605             


Ser Ala Asp Ala Thr His Phe Ser Ser Asn Asn Ser Gly Thr Asp Lys 
    610                 615                 620                 


Asn Ile Ser Glu Ala Pro Ala Ser Glu Ala Ser Ser Thr Val Thr Ala 
625                 630                 635                 640 


Arg Ile Asp Arg Leu Ile Asn Glu Phe Ala Gln Cys Gly Leu Thr Lys 
                645                 650                 655     


Leu Pro Lys Asn Glu Lys Lys Ile Leu Ser Ser Val Ala Ser Lys Lys 
            660                 665                 670         


Lys Lys Lys Ser Arg Gln Gln Ala Ile Asn Ser Arg Tyr Gln Asp Gly 
        675                 680                 685             


Gln Leu Ala Thr Lys Gly Ile Leu Asn Lys Asn Glu Arg Ile Asn Thr 
    690                 695                 700                 


Lys Gly Arg Ile Thr Lys Glu Met Ile Val Gln Asp Ser Asp Ser Pro 
705                 710                 715                 720 


Leu Lys Gly Gly Ile Leu Cys Glu Glu Asp Leu Gln Lys Ser Asp Thr 
                725                 730                 735     


Val Ile Glu Ser Asn Thr Phe Cys Ser Lys Ser Asn Leu Asn Ser Thr 
            740                 745                 750         


Ile Ser Lys Asn Phe His Arg Asn Lys Leu Asn Thr Thr Gln Asn Ser 
        755                 760                 765             


Lys Val Gln Gly Leu Leu Thr Lys Arg Lys Ser Arg Ser Leu Asn Lys 
    770                 775                 780                 


Ile Ser Leu Gly Ala Pro Lys Lys Arg Glu Ile Gly Gln Arg Asp Lys 
785                 790                 795                 800 


Val Phe Pro His Asn Glu Ser Lys Tyr Cys Lys Ser Thr Phe Glu Asn 
                805                 810                 815     


Lys Ser Leu Phe His Val Phe Asn Ile Leu Glu Gln Lys Pro Lys Asp 
            820                 825                 830         


Phe Tyr Ala Pro Gln Ser Gln Ala Glu Val Ala Ser Gly Tyr Leu Arg 
        835                 840                 845             


Gly Met Ala Lys Lys Ser Leu Val Ser Lys Val Thr Asp Ser His Ile 
    850                 855                 860                 


Thr Leu Lys Ser Gln Lys Lys Arg Lys Gly Asp Lys Val Lys Ala Ser 
865                 870                 875                 880 


Ala Ile Leu Ser Lys Gln His Ala Thr Thr Arg Ala Asn Ser Leu Ala 
                885                 890                 895     


Ser Leu Lys Lys Pro Asp Phe Pro Glu Ala Ile Ala His His Ser Ile 
            900                 905                 910         


Gln Asn Tyr Ile Gln Ser Trp Leu Gln Asn Ile Asn Pro Tyr Pro Thr 
        915                 920                 925             


Leu Lys Pro Ile Lys Ser Ala Pro Val Cys Arg Asn Glu Thr Ser Val 
    930                 935                 940                 


Val Asn Cys Ser Asn Asn Ser Phe Ser Gly Asn Asp Pro His Thr Asn 
945                 950                 955                 960 


Ser Gly Lys Ile Ser Asn Phe Val Met Glu Ser Asn Lys His Ile Thr 
                965                 970                 975     


Lys Ile Ala Gly Leu Thr Gly Asp Asn Leu Cys Lys Glu Gly Asp Lys 
            980                 985                 990         


Ser Phe Ile Ala Asn Asp Thr Gly  Glu Glu Asp Leu His  Glu Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Leu Asn Asp Ala  Tyr Leu Val Pro Leu  His Glu His 
    1010                 1015                 1020             


Cys Thr  Leu Ser Gln Ser Ala  Ile Asn Asp His Asn  Thr Lys Ser 
    1025                 1030                 1035             


His Ile  Ala Ala Glu Lys Ser  Gly Pro Glu Lys Lys  Leu Val Tyr 
    1040                 1045                 1050             


Gln Glu  Ile Asn Leu Ala Arg  Lys Arg Gln Ser Val  Glu Ala Ala 
    1055                 1060                 1065             


Ile Gln  Val Asp Pro Ile Glu  Glu Glu Thr Pro Lys  Asp Leu Leu 
    1070                 1075                 1080             


Pro Val  Leu Met Leu His Gln  Leu Gln Ala Ser Val  Pro Gly Ile 
    1085                 1090                 1095             


His Lys  Thr Gln Asn Gly Val  Val Gln Met Pro Gly  Ser Leu Ala 
    1100                 1105                 1110             


Gly Val  Pro Phe His Ser Ala  Ile Cys Asn Ser Ser  Thr Asn Leu 
    1115                 1120                 1125             


Leu Leu  Ala Trp Leu Leu Val  Leu Asn Leu Lys Gly  Ser Met Asn 
    1130                 1135                 1140             


Ser Phe  Cys Gln Val Asp Ala  His Lys Ala Thr Asn  Lys Ser Ser 
    1145                 1150                 1155             


Glu Thr  Leu Ala Leu Leu Glu  Ile Leu Lys His Ile  Ala Ile Thr 
    1160                 1165                 1170             


Glu Glu  Ala Asp Asp Leu Lys  Ala Ala Val Ala Asn  Leu Val Glu 
    1175                 1180                 1185             


Ser Thr  Thr Ser His Phe Gly  Leu Ser Glu Lys Glu  Gln Asp Met 
    1190                 1195                 1200             


Val Pro  Ile Asp Leu Ser Ala  Asn Cys Ser Thr Val  Asn Ile Gln 
    1205                 1210                 1215             


Ser Val  Pro Lys Cys Ser Glu  Asn Glu Arg Thr Gln  Gly Ile Ser 
    1220                 1225                 1230             


Ser Leu  Asp Gly Gly Cys Ser  Ala Ser Glu Ala Cys  Ala Pro Glu 
    1235                 1240                 1245             


Val Cys  Val Leu Glu Val Thr  Cys Ser Pro Cys Glu  Met Cys Thr 
    1250                 1255                 1260             


Val Asn  Lys Ala Tyr Ser Pro  Lys Glu Thr Cys Asn  Pro Ser Asp 
    1265                 1270                 1275             


Thr Phe  Phe Pro Ser Asp Gly  Tyr Gly Val Asp Gln  Thr Ser Met 
    1280                 1285                 1290             


Asn Lys  Ala Cys Phe Leu Gly  Glu Val Cys Ser Leu  Thr Asp Thr 
    1295                 1300                 1305             


Val Phe  Ser Asp Lys Ala Cys  Ala Gln Lys Glu Asn  His Thr Tyr 
    1310                 1315                 1320             


Glu Gly  Ala Cys Pro Ile Asp  Glu Thr Tyr Val Pro  Val Asn Val 
    1325                 1330                 1335             


Cys Asn  Thr Ile Asp Phe Leu  Asn Ser Lys Glu Asn  Thr Tyr Thr 
    1340                 1345                 1350             


Asp Asn  Leu Asp Ser Thr Glu  Glu Leu Glu Arg Gly  Asp Asp Ile 
    1355                 1360                 1365             


Gln Lys  Asp Leu Asn Ile Leu  Thr Asp Pro Glu Tyr  Lys Asn Gly 
    1370                 1375                 1380             


Phe Asn  Thr Leu Val Ser His  Gln Asn Val Ser Asn  Leu Ser Ser 
    1385                 1390                 1395             


Cys Gly  Leu Cys Leu Ser Glu  Lys Glu Ala Glu Leu  Asp Lys Lys 
    1400                 1405                 1410             


His Ser  Ser Leu Asp Asp Phe  Glu Asn Cys Ser Leu  Arg Lys Phe 
    1415                 1420                 1425             


Gln Asp  Glu Asn Ala Tyr Thr  Ser Phe Asp Met Glu  Glu Pro Arg 
    1430                 1435                 1440             


Thr Ser  Glu Glu Pro Gly Ser  Ile Thr Asn Ser Met  Thr Ser Ser 
    1445                 1450                 1455             


Glu Arg  Asn Ile Ser Glu Leu  Glu Ser Phe Glu Glu  Leu Glu Asn 
    1460                 1465                 1470             


His Asp  Thr Asp Ile Phe Asn  Thr Val Val Asn Gly  Gly Glu Gln 
    1475                 1480                 1485             


Ala Thr  Glu Glu Leu Ile Gln  Glu Glu Val Glu Ala  Ser Lys Thr 
    1490                 1495                 1500             


Leu Glu  Leu Ile Asp Ile Ser  Ser Lys Asn Ile Met  Glu Glu Lys 
    1505                 1510                 1515             


Arg Met  Asn Gly Ile Ile Tyr  Glu Ile Ile Ser Lys  Arg Leu Ala 
    1520                 1525                 1530             


Thr Pro  Pro Ser Leu Asp Phe  Cys Tyr Asp Ser Lys  Gln Asn Ser 
    1535                 1540                 1545             


Glu Lys  Glu Thr Asn Glu Gly  Glu Thr Lys Met Val  Lys Met Met 
    1550                 1555                 1560             


Val Lys  Thr Met Glu Thr Gly  Ser Tyr Ser Glu Ser  Ser Pro Asp 
    1565                 1570                 1575             


Leu Lys  Lys Cys Ile Lys Ser  Pro Val Thr Ser Asp  Trp Ser Asp 
    1580                 1585                 1590             


Tyr Arg  Pro Asp Ser Asp Ser  Glu Gln Pro Tyr Lys  Thr Ser Ser 
    1595                 1600                 1605             


Asp Asp  Pro Asn Asp Ser Gly  Glu Leu Thr Gln Glu  Lys Glu Tyr 
    1610                 1615                 1620             


Asn Ile  Gly Phe Val Lys Arg  Ala Ile Glu Lys Leu  Tyr Gly Lys 
    1625                 1630                 1635             


Ala Asp  Ile Ile Lys Pro Ser  Phe Phe Pro Gly Ser  Thr Arg Lys 
    1640                 1645                 1650             


Ser Gln  Val Cys Pro Tyr Asn  Ser Val Glu Phe Gln  Cys Ser Arg 
    1655                 1660                 1665             


Lys Ala  Ser Leu Tyr Asp Ser  Glu Gly Gln Ser Phe  Gly Ser Ser 
    1670                 1675                 1680             


Glu Gln  Val Ser Ser Ser Ser  Ser Met Leu Gln Glu  Phe Gln Glu 
    1685                 1690                 1695             


Glu Arg  Gln Asp Lys Cys Asp  Val Ser Ala Val Arg  Asp Asn Tyr 
    1700                 1705                 1710             


Cys Arg  Gly Asp Ile Val Glu  Pro Gly Thr Lys Gln  Asn Asp Asp 
    1715                 1720                 1725             


Ser Arg  Ile Leu Thr Asp Ile  Glu Glu Gly Val Leu  Ile Asp Lys 
    1730                 1735                 1740             


Gly Lys  Trp Leu Leu Lys Glu  Asn His Leu Leu Arg  Met Ser Ser 
    1745                 1750                 1755             


Glu Asn  Pro Gly Met Cys Gly  Asn Ala Asp Thr Thr  Ser Val Asp 
    1760                 1765                 1770             


Thr Leu  Leu Asp Asn Asn Ser  Ser Glu Val Pro Tyr  Ser His Phe 
    1775                 1780                 1785             


Gly Asn  Leu Ala Pro Gly Pro  Thr Met Asp Glu Leu  Ser Ser Ser 
    1790                 1795                 1800             


Glu Leu  Glu Glu Leu Thr Gln  Pro Leu Glu Leu Lys  Cys Asn Tyr 
    1805                 1810                 1815             


Phe Asn  Met Pro His Gly Ser  Asp Ser Glu Pro Phe  His Glu Asp 
    1820                 1825                 1830             


Leu Leu  Asp Val Arg Asn Glu  Thr Cys Ala Lys Glu  Arg Ile Ala 
    1835                 1840                 1845             


Asn His  His Thr Glu Glu Lys  Gly Ser His Gln Ser  Glu Arg Val 
    1850                 1855                 1860             


Cys Thr  Ser Val Thr His Ser  Phe Ile Ser Ala Gly  Asn Lys Val 
    1865                 1870                 1875             


Tyr Pro  Val Ser Asp Asp Ala  Ile Lys Asn Gln Pro  Leu Pro Gly 
    1880                 1885                 1890             


Ser Asn  Met Ile His Gly Thr  Leu Gln Glu Ala Asp  Ser Leu Asp 
    1895                 1900                 1905             


Lys Leu  Tyr Ala Leu Cys Gly  Gln His Cys Pro Ile  Leu Thr Val 
    1910                 1915                 1920             


Ile Ile  Gln Pro Met Asn Glu  Glu Asp Arg Gly Phe  Ala Tyr Arg 
    1925                 1930                 1935             


Lys Glu  Ser Asp Ile Glu Asn  Phe Leu Gly Phe Tyr  Leu Trp Met 
    1940                 1945                 1950             


Lys Ile  His Pro Tyr Leu Leu  Gln Thr Asp Lys Asn  Val Phe Arg 
    1955                 1960                 1965             


Glu Glu  Asn Asn Lys Ala Ser  Met Arg Gln Asn Leu  Ile Asp Asn 
    1970                 1975                 1980             


Ala Ile  Gly Asp Ile Phe Asp  Gln Phe Tyr Phe Ser  Asn Thr Phe 
    1985                 1990                 1995             


Asp Leu  Met Gly Lys Arg Arg  Lys Gln Lys Arg Ile  Asn Phe Leu 
    2000                 2005                 2010             


Gly Leu  Glu Glu Glu Gly Asn  Leu Lys Lys Phe Gln  Pro Asp Leu 
    2015                 2020                 2025             


Lys Glu  Arg Phe Cys Met Asn  Phe Leu His Thr Ser  Leu Leu Val 
    2030                 2035                 2040             


Val Gly  Asn Val Asp Ser Asn  Thr Gln Asp Leu Ser  Gly Gln Thr 
    2045                 2050                 2055             


Asn Glu  Ile Phe Lys Ala Val  Asp Glu Asn Asn Asn  Leu Leu Asn 
    2060                 2065                 2070             


Asn Arg  Phe Gln Gly Ser Arg  Thr Asn Leu Asn Gln  Val Val Arg 
    2075                 2080                 2085             


Glu Asn  Ile Asn Cys His Tyr  Phe Phe Glu Met Leu  Gly Gln Ala 
    2090                 2095                 2100             


Cys Leu  Leu Asp Ile Cys Gln  Val Glu Thr Ser Leu  Asn Ile Ser 
    2105                 2110                 2115             


Asn Arg  Asn Ile Leu Glu Leu  Cys Met Phe Glu Gly  Glu Asn Leu 
    2120                 2125                 2130             


Phe Ile  Trp Glu Glu Glu Asp  Ile Leu Asn Leu Thr  Asp Leu Glu 
    2135                 2140                 2145             


Ser Ser  Arg Glu Gln Glu Asp  Leu 
    2150                 2155     


<210>  33
<211>  350
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(350)
<223>  RP2 (protein XRP2)

<400>  33

Met Gly Cys Phe Phe Ser Lys Arg Arg Lys Ala Asp Lys Glu Ser Arg 
1               5                   10                  15      


Pro Glu Asn Glu Glu Glu Arg Pro Lys Gln Tyr Ser Trp Asp Gln Arg 
            20                  25                  30          


Glu Lys Val Asp Pro Lys Asp Tyr Met Phe Ser Gly Leu Lys Asp Glu 
        35                  40                  45              


Thr Val Gly Arg Leu Pro Gly Thr Val Ala Gly Gln Gln Phe Leu Ile 
    50                  55                  60                  


Gln Asp Cys Glu Asn Cys Asn Ile Tyr Ile Phe Asp His Ser Ala Thr 
65                  70                  75                  80  


Val Thr Ile Asp Asp Cys Thr Asn Cys Ile Ile Phe Leu Gly Pro Val 
                85                  90                  95      


Lys Gly Ser Val Phe Phe Arg Asn Cys Arg Asp Cys Lys Cys Thr Leu 
            100                 105                 110         


Ala Cys Gln Gln Phe Arg Val Arg Asp Cys Arg Lys Leu Glu Val Phe 
        115                 120                 125             


Leu Cys Cys Ala Thr Gln Pro Ile Ile Glu Ser Ser Ser Asn Ile Lys 
    130                 135                 140                 


Phe Gly Cys Phe Gln Trp Tyr Tyr Pro Glu Leu Ala Phe Gln Phe Lys 
145                 150                 155                 160 


Asp Ala Gly Leu Ser Ile Phe Asn Asn Thr Trp Ser Asn Ile His Asp 
                165                 170                 175     


Phe Thr Pro Val Ser Gly Glu Leu Asn Trp Ser Leu Leu Pro Glu Asp 
            180                 185                 190         


Ala Val Val Gln Asp Tyr Val Pro Ile Pro Thr Thr Glu Glu Leu Lys 
        195                 200                 205             


Ala Val Arg Val Ser Thr Glu Ala Asn Arg Ser Ile Val Pro Ile Ser 
    210                 215                 220                 


Arg Gly Gln Arg Gln Lys Ser Ser Asp Glu Ser Cys Leu Val Val Leu 
225                 230                 235                 240 


Phe Ala Gly Asp Tyr Thr Ile Ala Asn Ala Arg Lys Leu Ile Asp Glu 
                245                 250                 255     


Met Val Gly Lys Gly Phe Phe Leu Val Gln Thr Lys Glu Val Ser Met 
            260                 265                 270         


Lys Ala Glu Asp Ala Gln Arg Val Phe Arg Glu Lys Ala Pro Asp Phe 
        275                 280                 285             


Leu Pro Leu Leu Asn Lys Gly Pro Val Ile Ala Leu Glu Phe Asn Gly 
    290                 295                 300                 


Asp Gly Ala Val Glu Val Cys Gln Leu Ile Val Asn Glu Ile Phe Asn 
305                 310                 315                 320 


Gly Thr Lys Met Phe Val Ser Glu Ser Lys Glu Thr Ala Ser Gly Asp 
                325                 330                 335     


Val Asp Ser Phe Tyr Asn Phe Ala Asp Ile Gln Met Gly Ile 
            340                 345                 350 


<210>  34
<211>  1020
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1020)
<223>  RPGR (X-linked retinitis pigmentosa GTPase regulator), isoform 1

<400>  34

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Gly Asn Asp Thr Gly Gln Val Gly 
            580                 585                 590         


Pro Gln Ala Asp Thr Asp Gly Glu Gly Leu Gln Lys Glu Val Tyr Arg 
        595                 600                 605             


His Glu Asn Asn Asn Gly Val Asp Gln Leu Asp Ala Lys Glu Ile Glu 
    610                 615                 620                 


Lys Glu Ser Asp Gly Gly His Ser Gln Lys Glu Ser Glu Ala Glu Glu 
625                 630                 635                 640 


Ile Asp Ser Glu Lys Glu Thr Lys Leu Ala Glu Ile Ala Gly Met Lys 
                645                 650                 655     


Asp Leu Arg Glu Arg Glu Lys Ser Thr Lys Lys Met Ser Pro Phe Phe 
            660                 665                 670         


Gly Asn Leu Pro Asp Arg Gly Met Asn Thr Glu Ser Glu Glu Asn Lys 
        675                 680                 685             


Asp Phe Val Lys Lys Arg Glu Ser Cys Lys Gln Asp Val Ile Phe Asp 
    690                 695                 700                 


Ser Glu Arg Glu Ser Val Glu Lys Pro Asp Ser Tyr Met Glu Gly Ala 
705                 710                 715                 720 


Ser Glu Ser Gln Gln Gly Ile Ala Asp Gly Phe Gln Gln Pro Glu Ala 
                725                 730                 735     


Ile Glu Phe Ser Ser Gly Glu Lys Glu Asp Asp Glu Val Glu Thr Asp 
            740                 745                 750         


Gln Asn Ile Arg Tyr Gly Arg Lys Leu Ile Glu Gln Gly Asn Glu Lys 
        755                 760                 765             


Glu Thr Lys Pro Ile Ile Ser Lys Ser Met Ala Lys Tyr Asp Phe Lys 
    770                 775                 780                 


Cys Asp Arg Leu Ser Glu Ile Pro Glu Glu Lys Glu Gly Ala Glu Asp 
785                 790                 795                 800 


Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala Asn Glu Glu 
                805                 810                 815     


Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu Ile Leu Ser 
            820                 825                 830         


Asp Asp Leu Thr Asp Lys Ala Glu Asp His Glu Phe Ser Lys Thr Glu 
        835                 840                 845             


Glu Leu Lys Leu Glu Asp Val Asp Glu Glu Ile Asn Ala Glu Asn Val 
    850                 855                 860                 


Glu Ser Lys Lys Lys Thr Val Gly Asp Asp Glu Ser Val Pro Thr Gly 
865                 870                 875                 880 


Tyr His Ser Lys Thr Glu Gly Ala Glu Arg Thr Asn Asp Asp Ser Ser 
                885                 890                 895     


Ala Glu Thr Ile Glu Lys Lys Glu Lys Ala Asn Leu Glu Glu Arg Ala 
            900                 905                 910         


Ile Cys Glu Tyr Asn Glu Asn Pro Lys Gly Tyr Met Leu Asp Asp Ala 
        915                 920                 925             


Asp Ser Ser Ser Leu Glu Ile Leu Glu Asn Ser Glu Thr Thr Pro Ser 
    930                 935                 940                 


Lys Asp Met Lys Lys Thr Lys Lys Ile Phe Leu Phe Lys Arg Val Pro 
945                 950                 955                 960 


Ser Ile Asn Gln Lys Ile Val Lys Asn Asn Asn Glu Pro Leu Pro Glu 
                965                 970                 975     


Ile Lys Ser Ile Gly Asp Gln Ile Ile Leu Lys Ser Asp Asn Lys Asp 
            980                 985                 990         


Ala Asp Gln Asn His Met Ser Gln  Asn His Gln Asn Ile  Pro Pro Thr 
        995                 1000                 1005             


Asn Thr  Glu Arg Arg Ser Lys  Ser Cys Thr Ile Leu  
    1010                 1015                 1020 


<210>  35
<211>  405
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(405)
<223>  SAG (S-arrestin)

<400>  35

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Tyr Val Thr 
    50                  55                  60                  


Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu Asp Ile Asp Val Ile Gly 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr Pro 
                85                  90                  95      


Pro Val Gly Ala Ala Ser Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 
            100                 105                 110         


Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 
        115                 120                 125             


Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 
    130                 135                 140                 


Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 
145                 150                 155                 160 


Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys Ser Ser Val Arg Leu 
                165                 170                 175     


Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro 
            180                 185                 190         


Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser Asp Lys Pro Leu His 
        195                 200                 205             


Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe His Gly Glu Pro Ile 
    210                 215                 220                 


Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu Lys Thr Val Lys Lys 
225                 230                 235                 240 


Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu Tyr Ser Ser 
                245                 250                 255     


Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu Ala Gln Glu Lys Val 
            260                 265                 270         


Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu 
        275                 280                 285             


Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys 
    290                 295                 300                 


His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys Glu Gly Ile 
305                 310                 315                 320 


Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
                325                 330                 335     


Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala 
            340                 345                 350         


Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp Pro Ala 
        355                 360                 365             


Lys Glu Ser Tyr Gln Asp Ala Asn Leu Val Phe Glu Glu Phe Ala Arg 
    370                 375                 380                 


His Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu Gly Lys Arg Asp Lys 
385                 390                 395                 400 


Asn Asp Val Asp Glu 
                405 


<210>  36
<211>  552
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(552)
<223>  USH1C (Usher syndrome type-1 C protein), isoform 1

<400>  36

Met Asp Arg Lys Val Ala Arg Glu Phe Arg His Lys Val Asp Phe Leu 
1               5                   10                  15      


Ile Glu Asn Asp Ala Glu Lys Asp Tyr Leu Tyr Asp Val Leu Arg Met 
            20                  25                  30          


Tyr His Gln Thr Met Asp Val Ala Val Leu Val Gly Asp Leu Lys Leu 
        35                  40                  45              


Val Ile Asn Glu Pro Ser Arg Leu Pro Leu Phe Asp Ala Ile Arg Pro 
    50                  55                  60                  


Leu Ile Pro Leu Lys His Gln Val Glu Tyr Asp Gln Leu Thr Pro Arg 
65                  70                  75                  80  


Arg Ser Arg Lys Leu Lys Glu Val Arg Leu Asp Arg Leu His Pro Glu 
                85                  90                  95      


Gly Leu Gly Leu Ser Val Arg Gly Gly Leu Glu Phe Gly Cys Gly Leu 
            100                 105                 110         


Phe Ile Ser His Leu Ile Lys Gly Gly Gln Ala Asp Ser Val Gly Leu 
        115                 120                 125             


Gln Val Gly Asp Glu Ile Val Arg Ile Asn Gly Tyr Ser Ile Ser Ser 
    130                 135                 140                 


Cys Thr His Glu Glu Val Ile Asn Leu Ile Arg Thr Lys Lys Thr Val 
145                 150                 155                 160 


Ser Ile Lys Val Arg His Ile Gly Leu Ile Pro Val Lys Ser Ser Pro 
                165                 170                 175     


Asp Glu Pro Leu Thr Trp Gln Tyr Val Asp Gln Phe Val Ser Glu Ser 
            180                 185                 190         


Gly Gly Val Arg Gly Ser Leu Gly Ser Pro Gly Asn Arg Glu Asn Lys 
        195                 200                 205             


Glu Lys Lys Val Phe Ile Ser Leu Val Gly Ser Arg Gly Leu Gly Cys 
    210                 215                 220                 


Ser Ile Ser Ser Gly Pro Ile Gln Lys Pro Gly Ile Phe Ile Ser His 
225                 230                 235                 240 


Val Lys Pro Gly Ser Leu Ser Ala Glu Val Gly Leu Glu Ile Gly Asp 
                245                 250                 255     


Gln Ile Val Glu Val Asn Gly Val Asp Phe Ser Asn Leu Asp His Lys 
            260                 265                 270         


Glu Ala Val Asn Val Leu Lys Ser Ser Arg Ser Leu Thr Ile Ser Ile 
        275                 280                 285             


Val Ala Ala Ala Gly Arg Glu Leu Phe Met Thr Asp Arg Glu Arg Leu 
    290                 295                 300                 


Ala Glu Ala Arg Gln Arg Glu Leu Gln Arg Gln Glu Leu Leu Met Gln 
305                 310                 315                 320 


Lys Arg Leu Ala Met Glu Ser Asn Lys Ile Leu Gln Glu Gln Gln Glu 
                325                 330                 335     


Met Glu Arg Gln Arg Arg Lys Glu Ile Ala Gln Lys Ala Ala Glu Glu 
            340                 345                 350         


Asn Glu Arg Tyr Arg Lys Glu Met Glu Gln Ile Val Glu Glu Glu Glu 
        355                 360                 365             


Lys Phe Lys Lys Gln Trp Glu Glu Asp Trp Gly Ser Lys Glu Gln Leu 
    370                 375                 380                 


Leu Leu Pro Lys Thr Ile Thr Ala Glu Val His Pro Val Pro Leu Arg 
385                 390                 395                 400 


Lys Pro Lys Tyr Asp Gln Gly Val Glu Pro Glu Leu Glu Pro Ala Asp 
                405                 410                 415     


Asp Leu Asp Gly Gly Thr Glu Glu Gln Gly Glu Gln Asp Phe Arg Lys 
            420                 425                 430         


Tyr Glu Glu Gly Phe Asp Pro Tyr Ser Met Phe Thr Pro Glu Gln Ile 
        435                 440                 445             


Met Gly Lys Asp Val Arg Leu Leu Arg Ile Lys Lys Glu Gly Ser Leu 
    450                 455                 460                 


Asp Leu Ala Leu Glu Gly Gly Val Asp Ser Pro Ile Gly Lys Val Val 
465                 470                 475                 480 


Val Ser Ala Val Tyr Glu Arg Gly Ala Ala Glu Arg His Gly Gly Ile 
                485                 490                 495     


Val Lys Gly Asp Glu Ile Met Ala Ile Asn Gly Lys Ile Val Thr Asp 
            500                 505                 510         


Tyr Thr Leu Ala Glu Ala Glu Ala Ala Leu Gln Lys Ala Trp Asn Gln 
        515                 520                 525             


Gly Gly Asp Trp Ile Asp Leu Val Val Ala Val Cys Pro Pro Lys Glu 
    530                 535                 540                 


Tyr Asp Asp Glu Leu Thr Phe Phe 
545                 550         


<210>  37
<211>  461
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(461)
<223>  USH1G (Usher syndrome type-1G protein)

<400>  37

Met Asn Asp Gln Tyr His Arg Ala Ala Arg Asp Gly Tyr Leu Glu Leu 
1               5                   10                  15      


Leu Lys Glu Ala Thr Arg Lys Glu Leu Asn Ala Pro Asp Glu Asp Gly 
            20                  25                  30          


Met Thr Pro Thr Leu Trp Ala Ala Tyr His Gly Asn Leu Glu Ser Leu 
        35                  40                  45              


Arg Leu Ile Val Ser Arg Gly Gly Asp Pro Asp Lys Cys Asp Ile Trp 
    50                  55                  60                  


Gly Asn Thr Pro Leu His Leu Ala Ala Ser Asn Gly His Leu His Cys 
65                  70                  75                  80  


Leu Ser Phe Leu Val Ser Phe Gly Ala Asn Ile Trp Cys Leu Asp Asn 
                85                  90                  95      


Asp Tyr His Thr Pro Leu Asp Met Ala Ala Met Lys Gly His Met Glu 
            100                 105                 110         


Cys Val Arg Tyr Leu Asp Ser Ile Ala Ala Lys Gln Ser Ser Leu Asn 
        115                 120                 125             


Pro Lys Leu Val Gly Lys Leu Lys Asp Lys Ala Phe Arg Glu Ala Glu 
    130                 135                 140                 


Arg Arg Ile Arg Glu Cys Ala Lys Leu Gln Arg Arg His His Glu Arg 
145                 150                 155                 160 


Met Glu Arg Arg Tyr Arg Arg Glu Leu Ala Glu Arg Ser Asp Thr Leu 
                165                 170                 175     


Ser Phe Ser Ser Leu Thr Ser Ser Thr Leu Ser Arg Arg Leu Gln His 
            180                 185                 190         


Leu Ala Leu Gly Ser His Leu Pro Tyr Ser Gln Ala Thr Leu His Gly 
        195                 200                 205             


Thr Ala Arg Gly Lys Thr Lys Met Gln Lys Lys Leu Glu Arg Arg Lys 
    210                 215                 220                 


Gln Gly Gly Glu Gly Thr Phe Lys Val Ser Glu Asp Gly Arg Lys Ser 
225                 230                 235                 240 


Ala Arg Ser Leu Ser Gly Leu Gln Leu Gly Ser Asp Val Met Phe Val 
                245                 250                 255     


Arg Gln Gly Thr Tyr Ala Asn Pro Lys Glu Trp Gly Arg Ala Pro Leu 
            260                 265                 270         


Arg Asp Met Phe Leu Ser Asp Glu Asp Ser Val Ser Arg Ala Thr Leu 
        275                 280                 285             


Ala Ala Glu Pro Ala His Ser Glu Val Ser Thr Asp Ser Gly His Asp 
    290                 295                 300                 


Ser Leu Phe Thr Arg Pro Gly Leu Gly Thr Met Val Phe Arg Arg Asn 
305                 310                 315                 320 


Tyr Leu Ser Ser Gly Leu His Gly Leu Gly Arg Glu Asp Gly Gly Leu 
                325                 330                 335     


Asp Gly Val Gly Ala Pro Arg Gly Arg Leu Gln Ser Ser Pro Ser Leu 
            340                 345                 350         


Asp Asp Asp Ser Leu Gly Ser Ala Asn Ser Leu Gln Asp Arg Ser Cys 
        355                 360                 365             


Gly Glu Glu Leu Pro Trp Asp Glu Leu Asp Leu Gly Leu Asp Glu Asp 
    370                 375                 380                 


Leu Glu Pro Glu Thr Ser Pro Leu Glu Thr Phe Leu Ala Ser Leu His 
385                 390                 395                 400 


Met Glu Asp Phe Ala Ala Leu Leu Arg Gln Glu Lys Ile Asp Leu Glu 
                405                 410                 415     


Ala Leu Met Leu Cys Ser Asp Leu Asp Leu Arg Ser Ile Ser Val Pro 
            420                 425                 430         


Leu Gly Pro Arg Lys Lys Ile Leu Gly Ala Val Arg Arg Arg Arg Gln 
        435                 440                 445             


Ala Met Glu Arg Pro Pro Ala Leu Glu Asp Thr Glu Leu 
    450                 455                 460     


<210>  38
<211>  5202
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5202)
<223>  USH2A (Usherin), isoform 1

<400>  38

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Arg Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Ile Lys  Ala Ser Phe 
    1535                 1540                 1545             


Arg Thr  Lys Val Pro Glu Gly  Leu Ile Val Phe Ala  Ala Ser Pro 
    1550                 1555                 1560             


Gly Asn  Gln Glu Glu Tyr Phe  Ala Leu Gln Leu Lys  Lys Gly Arg 
    1565                 1570                 1575             


Leu Tyr  Phe Leu Phe Asp Pro  Gln Gly Ser Pro Val  Glu Val Thr 
    1580                 1585                 1590             


Thr Thr  Asn Asp His Gly Lys  Gln Tyr Ser Asp Gly  Lys Trp His 
    1595                 1600                 1605             


Glu Ile  Ile Ala Ile Arg His  Gln Ala Phe Gly Gln  Ile Thr Leu 
    1610                 1615                 1620             


Asp Gly  Ile Tyr Thr Gly Ser  Ser Ala Ile Leu Asn  Gly Ser Thr 
    1625                 1630                 1635             


Val Ile  Gly Asp Asn Thr Gly  Val Phe Leu Gly Gly  Leu Pro Arg 
    1640                 1645                 1650             


Ser Tyr  Thr Ile Leu Arg Lys  Asp Pro Glu Ile Ile  Gln Lys Gly 
    1655                 1660                 1665             


Phe Val  Gly Cys Leu Lys Asp  Val His Phe Met Lys  Asn Tyr Asn 
    1670                 1675                 1680             


Pro Ser  Ala Ile Trp Glu Pro  Leu Asp Trp Gln Ser  Ser Glu Glu 
    1685                 1690                 1695             


Gln Ile  Asn Val Tyr Asn Ser  Trp Glu Gly Cys Pro  Ala Ser Leu 
    1700                 1705                 1710             


Asn Glu  Gly Ala Gln Phe Leu  Gly Ala Gly Phe Leu  Glu Leu His 
    1715                 1720                 1725             


Pro Tyr  Met Phe His Gly Gly  Met Asn Phe Glu Ile  Ser Phe Lys 
    1730                 1735                 1740             


Phe Arg  Thr Asp Gln Leu Asn  Gly Leu Leu Leu Phe  Val Tyr Asn 
    1745                 1750                 1755             


Lys Asp  Gly Pro Asp Phe Leu  Ala Met Glu Leu Lys  Ser Gly Ile 
    1760                 1765                 1770             


Leu Thr  Phe Arg Leu Asn Thr  Ser Leu Ala Phe Thr  Gln Val Asp 
    1775                 1780                 1785             


Leu Leu  Leu Gly Leu Ser Tyr  Cys Asn Gly Lys Trp  Asn Lys Val 
    1790                 1795                 1800             


Ile Ile  Lys Lys Glu Gly Ser  Phe Ile Ser Ala Ser  Val Asn Gly 
    1805                 1810                 1815             


Leu Met  Lys His Ala Ser Glu  Ser Gly Asp Gln Pro  Leu Val Val 
    1820                 1825                 1830             


Asn Ser  Pro Val Tyr Val Gly  Gly Ile Pro Gln Glu  Leu Leu Asn 
    1835                 1840                 1845             


Ser Tyr  Gln His Leu Cys Leu  Glu Gln Gly Phe Gly  Gly Cys Met 
    1850                 1855                 1860             


Lys Asp  Val Lys Phe Thr Arg  Gly Ala Val Val Asn  Leu Ala Ser 
    1865                 1870                 1875             


Val Ser  Ser Gly Ala Val Arg  Val Asn Leu Asp Gly  Cys Leu Ser 
    1880                 1885                 1890             


Thr Asp  Ser Ala Val Asn Cys  Arg Gly Asn Asp Ser  Ile Leu Val 
    1895                 1900                 1905             


Tyr Gln  Gly Lys Glu Gln Ser  Val Tyr Glu Gly Gly  Leu Gln Pro 
    1910                 1915                 1920             


Phe Thr  Glu Tyr Leu Tyr Arg  Val Ile Ala Ser His  Glu Gly Gly 
    1925                 1930                 1935             


Ser Val  Tyr Ser Asp Trp Ser  Arg Gly Arg Thr Thr  Gly Ala Ala 
    1940                 1945                 1950             


Pro Gln  Ser Val Pro Thr Pro  Ser Arg Val Arg Ser  Leu Asn Gly 
    1955                 1960                 1965             


Tyr Ser  Ile Glu Val Thr Trp  Asp Glu Pro Val Val  Arg Gly Val 
    1970                 1975                 1980             


Ile Glu  Lys Tyr Ile Leu Lys  Ala Tyr Ser Glu Asp  Ser Thr Arg 
    1985                 1990                 1995             


Pro Pro  Arg Met Pro Ser Ala  Ser Ala Glu Phe Val  Asn Thr Ser 
    2000                 2005                 2010             


Asn Leu  Thr Gly Ile Leu Thr  Gly Leu Leu Pro Phe  Lys Asn Tyr 
    2015                 2020                 2025             


Ala Val  Thr Leu Thr Ala Cys  Thr Leu Ala Gly Cys  Thr Glu Ser 
    2030                 2035                 2040             


Ser His  Ala Leu Asn Ile Ser  Thr Pro Gln Glu Ala  Pro Gln Glu 
    2045                 2050                 2055             


Val Gln  Pro Pro Val Ala Lys  Ser Leu Pro Ser Ser  Leu Leu Leu 
    2060                 2065                 2070             


Ser Trp  Asn Pro Pro Lys Lys  Ala Asn Gly Ile Ile  Thr Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Tyr Met Asp Gly Arg  Leu Ile Tyr Ser Gly  Ser Glu Glu 
    2090                 2095                 2100             


Asn Tyr  Ile Val Thr Asp Leu  Ala Val Phe Thr Pro  His Gln Phe 
    2105                 2110                 2115             


Leu Leu  Ser Ala Cys Thr His  Val Gly Cys Thr Asn  Ser Ser Trp 
    2120                 2125                 2130             


Val Leu  Leu Tyr Thr Ala Gln  Leu Pro Pro Glu His  Val Asp Ser 
    2135                 2140                 2145             


Pro Val  Leu Thr Val Leu Asp  Ser Arg Thr Ile His  Ile Gln Trp 
    2150                 2155                 2160             


Lys Gln  Pro Arg Lys Ile Ser  Gly Ile Leu Glu Arg  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Met  Ser Asn His Thr His  Asp Phe Thr Ile Trp  Ser Val Ile 
    2180                 2185                 2190             


Tyr Asn  Ser Thr Glu Leu Phe  Gln Asp His Met Leu  Gln Tyr Val 
    2195                 2200                 2205             


Leu Pro  Gly Asn Lys Tyr Leu  Ile Lys Leu Gly Ala  Cys Thr Gly 
    2210                 2215                 2220             


Gly Gly  Cys Thr Val Ser Glu  Ala Ser Glu Ala Leu  Thr Asp Glu 
    2225                 2230                 2235             


Asp Ile  Pro Glu Gly Val Pro  Ala Pro Lys Ala His  Ser Tyr Ser 
    2240                 2245                 2250             


Pro Asp  Ser Phe Asn Val Ser  Trp Thr Glu Pro Glu  Tyr Pro Asn 
    2255                 2260                 2265             


Gly Val  Ile Thr Ser Tyr Gly  Leu Tyr Leu Asp Gly  Ile Leu Ile 
    2270                 2275                 2280             


His Asn  Ser Ser Glu Leu Ser  Tyr Arg Ala Tyr Gly  Phe Ala Pro 
    2285                 2290                 2295             


Trp Ser  Leu His Ser Phe Arg  Val Gln Ala Cys Thr  Ala Lys Gly 
    2300                 2305                 2310             


Cys Ala  Leu Gly Pro Leu Val  Glu Asn Arg Thr Leu  Glu Ala Pro 
    2315                 2320                 2325             


Pro Glu  Gly Thr Val Asn Val  Phe Val Lys Thr Gln  Gly Ser Arg 
    2330                 2335                 2340             


Lys Ala  His Val Arg Trp Glu  Ala Pro Phe Arg Pro  Asn Gly Leu 
    2345                 2350                 2355             


Leu Thr  His Ser Val Leu Phe  Thr Gly Ile Phe Tyr  Val Asp Pro 
    2360                 2365                 2370             


Val Gly  Asn Asn Tyr Thr Leu  Leu Asn Val Thr Lys  Val Met Tyr 
    2375                 2380                 2385             


Ser Gly  Glu Glu Thr Asn Leu  Trp Val Leu Ile Asp  Gly Leu Val 
    2390                 2395                 2400             


Pro Phe  Thr Asn Tyr Thr Val  Gln Val Asn Ile Ser  Asn Ser Gln 
    2405                 2410                 2415             


Gly Ser  Leu Ile Thr Asp Pro  Ile Thr Ile Ala Met  Pro Pro Gly 
    2420                 2425                 2430             


Ala Pro  Asp Gly Val Leu Pro  Pro Arg Leu Ser Ser  Ala Thr Pro 
    2435                 2440                 2445             


Thr Ser  Leu Gln Val Val Trp  Ser Thr Pro Ala Arg  Asn Asn Ala 
    2450                 2455                 2460             


Pro Gly  Ser Pro Arg Tyr Gln  Leu Gln Met Arg Ser  Gly Asp Ser 
    2465                 2470                 2475             


Thr His  Gly Phe Leu Glu Leu  Phe Ser Asn Pro Ser  Ala Ser Leu 
    2480                 2485                 2490             


Ser Tyr  Glu Val Ser Asp Leu  Gln Pro Tyr Thr Glu  Tyr Met Phe 
    2495                 2500                 2505             


Arg Leu  Val Ala Ser Asn Gly  Phe Gly Ser Ala His  Ser Ser Trp 
    2510                 2515                 2520             


Ile Pro  Phe Met Thr Ala Glu  Asp Lys Pro Gly Pro  Val Val Pro 
    2525                 2530                 2535             


Pro Ile  Leu Leu Asp Val Lys  Ser Arg Met Met Leu  Val Thr Trp 
    2540                 2545                 2550             


Gln His  Pro Arg Lys Ser Asn  Gly Val Ile Thr His  Tyr Asn Ile 
    2555                 2560                 2565             


Tyr Leu  His Gly Arg Leu Tyr  Leu Arg Thr Pro Gly  Asn Val Thr 
    2570                 2575                 2580             


Asn Cys  Thr Val Met His Leu  His Pro Tyr Thr Ala  Tyr Lys Phe 
    2585                 2590                 2595             


Gln Val  Glu Ala Cys Thr Ser  Lys Gly Cys Ser Leu  Ser Pro Glu 
    2600                 2605                 2610             


Ser Gln  Thr Val Trp Thr Leu  Pro Gly Ala Pro Glu  Gly Ile Pro 
    2615                 2620                 2625             


Ser Pro  Glu Leu Phe Ser Asp  Thr Pro Thr Ser Val  Ile Ile Ser 
    2630                 2635                 2640             


Trp Gln  Pro Pro Thr His Pro  Asn Gly Leu Val Glu  Asn Phe Thr 
    2645                 2650                 2655             


Ile Glu  Arg Arg Val Lys Gly  Lys Glu Glu Val Thr  Thr Leu Val 
    2660                 2665                 2670             


Thr Leu  Pro Arg Ser His Ser  Met Arg Phe Ile Asp  Lys Thr Ser 
    2675                 2680                 2685             


Ala Leu  Ser Pro Trp Thr Lys  Tyr Glu Tyr Arg Val  Leu Met Ser 
    2690                 2695                 2700             


Thr Leu  His Gly Gly Thr Asn  Ser Ser Ala Trp Val  Glu Val Thr 
    2705                 2710                 2715             


Thr Arg  Pro Ser Arg Pro Ala  Gly Val Gln Pro Pro  Val Val Thr 
    2720                 2725                 2730             


Val Leu  Glu Pro Asp Ala Val  Gln Val Thr Trp Lys  Pro Pro Leu 
    2735                 2740                 2745             


Ile Gln  Asn Gly Asp Ile Leu  Ser Tyr Glu Ile His  Met Pro Asp 
    2750                 2755                 2760             


Pro His  Ile Thr Leu Thr Asn  Val Thr Ser Ala Val  Leu Ser Gln 
    2765                 2770                 2775             


Lys Val  Thr His Leu Ile Pro  Phe Thr Asn Tyr Ser  Val Thr Ile 
    2780                 2785                 2790             


Val Ala  Cys Ser Gly Gly Asn  Gly Tyr Leu Gly Gly  Cys Thr Glu 
    2795                 2800                 2805             


Ser Leu  Pro Thr Tyr Val Thr  Thr His Pro Thr Val  Pro Gln Asn 
    2810                 2815                 2820             


Val Gly  Pro Leu Ser Val Ile  Pro Leu Ser Glu Ser  Tyr Val Val 
    2825                 2830                 2835             


Ile Ser  Trp Gln Pro Pro Ser  Lys Pro Asn Gly Pro  Asn Leu Arg 
    2840                 2845                 2850             


Tyr Glu  Leu Leu Arg Arg Lys  Ile Gln Gln Pro Leu  Ala Ser Asn 
    2855                 2860                 2865             


Pro Pro  Glu Asp Leu Asn Arg  Trp His Asn Ile Tyr  Ser Gly Thr 
    2870                 2875                 2880             


Gln Trp  Leu Tyr Glu Asp Lys  Gly Leu Ser Arg Phe  Thr Thr Tyr 
    2885                 2890                 2895             


Glu Tyr  Met Leu Phe Val His  Asn Ser Val Gly Phe  Thr Pro Ser 
    2900                 2905                 2910             


Arg Glu  Val Thr Val Thr Thr  Leu Ala Gly Leu Pro  Glu Arg Gly 
    2915                 2920                 2925             


Ala Asn  Leu Thr Ala Ser Val  Leu Asn His Thr Ala  Ile Asp Val 
    2930                 2935                 2940             


Arg Trp  Ala Lys Pro Thr Val  Gln Asp Leu Gln Gly  Glu Val Glu 
    2945                 2950                 2955             


Tyr Tyr  Thr Leu Phe Trp Ser  Ser Ala Thr Ser Asn  Asp Ser Leu 
    2960                 2965                 2970             


Lys Ile  Leu Pro Asp Val Asn  Ser His Val Ile Gly  His Leu Lys 
    2975                 2980                 2985             


Pro Asn  Thr Glu Tyr Trp Ile  Phe Ile Ser Val Phe  Asn Gly Val 
    2990                 2995                 3000             


His Ser  Ile Asn Ser Ala Gly  Leu His Ala Thr Thr  Cys Asp Gly 
    3005                 3010                 3015             


Glu Pro  Gln Gly Met Leu Pro  Pro Glu Val Val Ile  Ile Asn Ser 
    3020                 3025                 3030             


Thr Ala  Val Arg Val Ile Trp  Thr Ser Pro Ser Asn  Pro Asn Gly 
    3035                 3040                 3045             


Val Val  Thr Glu Tyr Ser Ile  Tyr Val Asn Asn Lys  Leu Tyr Lys 
    3050                 3055                 3060             


Thr Gly  Met Asn Val Pro Gly  Ser Phe Ile Leu Arg  Asp Leu Ser 
    3065                 3070                 3075             


Pro Phe  Thr Ile Tyr Asp Ile  Gln Val Glu Val Cys  Thr Ile Tyr 
    3080                 3085                 3090             


Ala Cys  Val Lys Ser Asn Gly  Thr Gln Ile Thr Thr  Val Glu Asp 
    3095                 3100                 3105             


Thr Pro  Ser Asp Ile Pro Thr  Pro Thr Ile Arg Gly  Ile Thr Ser 
    3110                 3115                 3120             


Arg Ser  Leu Gln Ile Asp Trp  Val Ser Pro Arg Lys  Pro Asn Gly 
    3125                 3130                 3135             


Ile Ile  Leu Gly Tyr Asp Leu  Leu Trp Lys Thr Trp  Tyr Pro Cys 
    3140                 3145                 3150             


Ala Lys  Thr Gln Lys Leu Val  Gln Asp Gln Ser Asp  Glu Leu Cys 
    3155                 3160                 3165             


Lys Ala  Val Arg Cys Gln Lys  Pro Glu Ser Ile Cys  Gly His Ile 
    3170                 3175                 3180             


Cys Tyr  Ser Ser Glu Ala Lys  Val Cys Cys Asn Gly  Val Leu Tyr 
    3185                 3190                 3195             


Asn Pro  Lys Pro Gly His Arg  Cys Cys Glu Glu Lys  Tyr Ile Pro 
    3200                 3205                 3210             


Phe Val  Leu Asn Ser Thr Gly  Val Cys Cys Gly Gly  Arg Ile Gln 
    3215                 3220                 3225             


Glu Ala  Gln Pro Asn His Gln  Cys Cys Ser Gly Tyr  Tyr Ala Arg 
    3230                 3235                 3240             


Ile Leu  Pro Gly Glu Val Cys  Cys Pro Asp Glu Gln  His Asn Arg 
    3245                 3250                 3255             


Val Ser  Val Gly Ile Gly Asp  Ser Cys Cys Gly Arg  Met Pro Tyr 
    3260                 3265                 3270             


Ser Thr  Ser Gly Asn Gln Ile  Cys Cys Ala Gly Arg  Leu His Asp 
    3275                 3280                 3285             


Gly His  Gly Gln Lys Cys Cys  Gly Arg Gln Ile Val  Ser Asn Asp 
    3290                 3295                 3300             


Leu Glu  Cys Cys Gly Gly Glu  Glu Gly Val Val Tyr  Asn Arg Leu 
    3305                 3310                 3315             


Pro Gly  Met Phe Cys Cys Gly  Gln Asp Tyr Val Asn  Met Ser Asp 
    3320                 3325                 3330             


Thr Ile  Cys Cys Ser Ala Ser  Ser Gly Glu Ser Lys  Ala His Ile 
    3335                 3340                 3345             


Lys Lys  Asn Asp Pro Val Pro  Val Lys Cys Cys Glu  Thr Glu Leu 
    3350                 3355                 3360             


Ile Pro  Lys Ser Gln Lys Cys  Cys Asn Gly Val Gly  Tyr Asn Pro 
    3365                 3370                 3375             


Leu Lys  Tyr Val Cys Ser Asp  Lys Ile Ser Thr Gly  Met Met Met 
    3380                 3385                 3390             


Lys Glu  Thr Lys Glu Cys Arg  Ile Leu Cys Pro Ala  Ser Met Glu 
    3395                 3400                 3405             


Ala Thr  Glu His Cys Gly Arg  Cys Asp Phe Asn Phe  Thr Ser His 
    3410                 3415                 3420             


Ile Cys  Thr Val Ile Arg Gly  Ser His Asn Ser Thr  Gly Lys Ala 
    3425                 3430                 3435             


Ser Ile  Glu Glu Met Cys Ser  Ser Ala Glu Glu Thr  Ile His Thr 
    3440                 3445                 3450             


Gly Ser  Val Asn Thr Tyr Ser  Tyr Thr Asp Val Asn  Leu Lys Pro 
    3455                 3460                 3465             


Tyr Met  Thr Tyr Glu Tyr Arg  Ile Ser Ala Trp Asn  Ser Tyr Gly 
    3470                 3475                 3480             


Arg Gly  Leu Ser Lys Ala Val  Arg Ala Arg Thr Lys  Glu Asp Val 
    3485                 3490                 3495             


Pro Gln  Gly Val Ser Pro Pro  Thr Trp Thr Lys Ile  Asp Asn Leu 
    3500                 3505                 3510             


Glu Asp  Thr Ile Val Leu Asn  Trp Arg Lys Pro Ile  Gln Ser Asn 
    3515                 3520                 3525             


Gly Pro  Ile Ile Tyr Tyr Ile  Leu Leu Arg Asn Gly  Ile Glu Arg 
    3530                 3535                 3540             


Phe Arg  Gly Thr Ser Leu Ser  Phe Ser Asp Lys Glu  Gly Ile Gln 
    3545                 3550                 3555             


Pro Phe  Gln Glu Tyr Ser Tyr  Gln Leu Lys Ala Cys  Thr Val Ala 
    3560                 3565                 3570             


Gly Cys  Ala Thr Ser Ser Lys  Val Val Ala Ala Thr  Thr Gln Gly 
    3575                 3580                 3585             


Val Pro  Glu Ser Ile Leu Pro  Pro Ser Ile Thr Ala  Leu Ser Ala 
    3590                 3595                 3600             


Val Ala  Leu His Leu Ser Trp  Ser Val Pro Glu Lys  Ser Asn Gly 
    3605                 3610                 3615             


Val Ile  Lys Glu Tyr Gln Ile  Arg Gln Val Gly Lys  Gly Leu Ile 
    3620                 3625                 3630             


His Thr  Asp Thr Thr Asp Arg  Arg Gln His Thr Val  Thr Gly Leu 
    3635                 3640                 3645             


Gln Pro  Tyr Thr Asn Tyr Ser  Phe Thr Leu Thr Ala  Cys Thr Ser 
    3650                 3655                 3660             


Ala Gly  Cys Thr Ser Ser Glu  Pro Phe Leu Gly Gln  Thr Leu Gln 
    3665                 3670                 3675             


Ala Ala  Pro Glu Gly Val Trp  Val Thr Pro Arg His  Ile Ile Ile 
    3680                 3685                 3690             


Asn Ser  Thr Thr Val Glu Leu  Tyr Trp Ser Leu Pro  Glu Lys Pro 
    3695                 3700                 3705             


Asn Gly  Leu Val Ser Gln Tyr  Gln Leu Ser Arg Asn  Gly Asn Leu 
    3710                 3715                 3720             


Leu Phe  Leu Gly Gly Ser Glu  Glu Gln Asn Phe Thr  Asp Lys Asn 
    3725                 3730                 3735             


Leu Glu  Pro Asn Ser Arg Tyr  Thr Tyr Lys Leu Glu  Val Lys Thr 
    3740                 3745                 3750             


Gly Gly  Gly Ser Ser Ala Ser  Asp Asp Tyr Ile Val  Gln Thr Pro 
    3755                 3760                 3765             


Met Ser  Thr Pro Glu Glu Ile  Tyr Pro Pro Tyr Asn  Ile Thr Val 
    3770                 3775                 3780             


Ile Gly  Pro Tyr Ser Ile Phe  Val Ala Trp Ile Pro  Pro Gly Ile 
    3785                 3790                 3795             


Leu Ile  Pro Glu Ile Pro Val  Glu Tyr Asn Val Leu  Leu Asn Asp 
    3800                 3805                 3810             


Gly Ser  Val Thr Pro Leu Ala  Phe Ser Val Gly His  His Gln Ser 
    3815                 3820                 3825             


Thr Leu  Leu Glu Asn Leu Thr  Pro Phe Thr Gln Tyr  Glu Ile Arg 
    3830                 3835                 3840             


Ile Gln  Ala Cys Gln Asn Gly  Ser Cys Gly Val Ser  Ser Arg Met 
    3845                 3850                 3855             


Phe Val  Lys Thr Pro Glu Ala  Ala Pro Met Asp Leu  Asn Ser Pro 
    3860                 3865                 3870             


Val Leu  Lys Ala Leu Gly Ser  Ala Cys Ile Glu Ile  Lys Trp Met 
    3875                 3880                 3885             


Pro Pro  Glu Lys Pro Asn Gly  Ile Ile Ile Asn Tyr  Phe Ile Tyr 
    3890                 3895                 3900             


Arg Arg  Pro Ala Gly Ile Glu  Glu Glu Ser Val Leu  Phe Val Trp 
    3905                 3910                 3915             


Ser Glu  Gly Ala Leu Glu Phe  Met Asp Glu Gly Asp  Thr Leu Arg 
    3920                 3925                 3930             


Pro Phe  Thr Leu Tyr Glu Tyr  Arg Val Arg Ala Cys  Asn Ser Lys 
    3935                 3940                 3945             


Gly Ser  Val Glu Ser Leu Trp  Ser Leu Thr Gln Thr  Leu Glu Ala 
    3950                 3955                 3960             


Pro Pro  Gln Asp Phe Pro Ala  Pro Trp Ala Gln Ala  Thr Ser Ala 
    3965                 3970                 3975             


His Ser  Val Leu Leu Asn Trp  Thr Lys Pro Glu Ser  Pro Asn Gly 
    3980                 3985                 3990             


Ile Ile  Ser His Tyr Arg Val  Val Tyr Gln Glu Arg  Pro Asp Asp 
    3995                 4000                 4005             


Pro Thr  Phe Asn Ser Pro Thr  Val His Ala Phe Thr  Val Lys Gly 
    4010                 4015                 4020             


Thr Ser  His Gln Ala His Leu  Tyr Gly Leu Glu Pro  Phe Thr Thr 
    4025                 4030                 4035             


Tyr Arg  Ile Gly Val Val Ala  Ala Asn His Ala Gly  Glu Ile Leu 
    4040                 4045                 4050             


Ser Pro  Trp Thr Leu Ile Gln  Thr Leu Glu Ser Ser  Pro Ser Gly 
    4055                 4060                 4065             


Leu Arg  Asn Phe Ile Val Glu  Gln Lys Glu Asn Gly  Arg Ala Leu 
    4070                 4075                 4080             


Leu Leu  Gln Trp Ser Glu Pro  Met Arg Thr Asn Gly  Val Ile Lys 
    4085                 4090                 4095             


Thr Tyr  Asn Ile Phe Ser Asp  Gly Phe Leu Glu Tyr  Ser Gly Leu 
    4100                 4105                 4110             


Asn Arg  Gln Phe Leu Phe Arg  Arg Leu Asp Pro Phe  Thr Leu Tyr 
    4115                 4120                 4125             


Thr Leu  Thr Leu Glu Ala Cys  Thr Arg Ala Gly Cys  Ala His Ser 
    4130                 4135                 4140             


Ala Pro  Gln Pro Leu Trp Thr  Asp Glu Ala Pro Pro  Asp Ser Gln 
    4145                 4150                 4155             


Leu Ala  Pro Thr Val His Ser  Val Lys Ser Thr Ser  Val Glu Leu 
    4160                 4165                 4170             


Ser Trp  Ser Glu Pro Val Asn  Pro Asn Gly Lys Ile  Ile Arg Tyr 
    4175                 4180                 4185             


Glu Val  Ile Arg Arg Cys Phe  Glu Gly Lys Ala Trp  Gly Asn Gln 
    4190                 4195                 4200             


Thr Ile  Gln Ala Asp Glu Lys  Ile Val Phe Thr Glu  Tyr Asn Thr 
    4205                 4210                 4215             


Glu Arg  Asn Thr Phe Met Tyr  Asn Asp Thr Gly Leu  Gln Pro Trp 
    4220                 4225                 4230             


Thr Gln  Cys Glu Tyr Lys Ile  Tyr Thr Trp Asn Ser  Ala Gly His 
    4235                 4240                 4245             


Thr Cys  Ser Ser Trp Asn Val  Val Arg Thr Leu Gln  Ala Pro Pro 
    4250                 4255                 4260             


Glu Gly  Leu Ser Pro Pro Val  Ile Ser Tyr Val Ser  Met Asn Pro 
    4265                 4270                 4275             


Gln Lys  Leu Leu Ile Ser Trp  Ile Pro Pro Glu Gln  Ser Asn Gly 
    4280                 4285                 4290             


Ile Ile  Gln Ser Tyr Arg Leu  Gln Arg Asn Glu Met  Leu Tyr Pro 
    4295                 4300                 4305             


Phe Ser  Phe Asp Pro Val Thr  Phe Asn Tyr Thr Asp  Glu Glu Leu 
    4310                 4315                 4320             


Leu Pro  Phe Ser Thr Tyr Ser  Tyr Ala Leu Gln Ala  Cys Thr Ser 
    4325                 4330                 4335             


Gly Gly  Cys Ser Thr Ser Lys  Pro Thr Ser Ile Thr  Thr Leu Glu 
    4340                 4345                 4350             


Ala Ala  Pro Ser Glu Val Ser  Pro Pro Asp Leu Trp  Ala Val Ser 
    4355                 4360                 4365             


Ala Thr  Gln Met Asn Val Cys  Trp Ser Pro Pro Thr  Val Gln Asn 
    4370                 4375                 4380             


Gly Lys  Ile Thr Lys Tyr Leu  Val Arg Tyr Asp Asn  Lys Glu Ser 
    4385                 4390                 4395             


Leu Ala  Gly Gln Gly Leu Cys  Leu Leu Val Ser His  Leu Gln Pro 
    4400                 4405                 4410             


Tyr Ser  Gln Tyr Asn Phe Ser  Leu Val Ala Cys Thr  Asn Gly Gly 
    4415                 4420                 4425             


Cys Thr  Ala Ser Val Ser Lys  Ser Ala Trp Thr Met  Glu Ala Leu 
    4430                 4435                 4440             


Pro Glu  Asn Met Asp Ser Pro  Thr Leu Gln Val Thr  Gly Ser Glu 
    4445                 4450                 4455             


Ser Ile  Glu Ile Thr Trp Lys  Pro Pro Arg Asn Pro  Asn Gly Gln 
    4460                 4465                 4470             


Ile Arg  Ser Tyr Glu Leu Arg  Arg Asp Gly Thr Ile  Val Tyr Thr 
    4475                 4480                 4485             


Gly Leu  Glu Thr Arg Tyr Arg  Asp Phe Thr Leu Thr  Pro Gly Val 
    4490                 4495                 4500             


Glu Tyr  Ser Tyr Thr Val Thr  Ala Ser Asn Ser Gln  Gly Gly Ile 
    4505                 4510                 4515             


Leu Ser  Pro Leu Val Lys Asp  Arg Thr Ser Pro Ser  Ala Pro Ser 
    4520                 4525                 4530             


Gly Met  Glu Pro Pro Lys Leu  Gln Ala Arg Gly Pro  Gln Glu Ile 
    4535                 4540                 4545             


Leu Val  Asn Trp Asp Pro Pro  Val Arg Thr Asn Gly  Asp Ile Ile 
    4550                 4555                 4560             


Asn Tyr  Thr Leu Phe Ile Arg  Glu Leu Phe Glu Arg  Glu Thr Lys 
    4565                 4570                 4575             


Ile Ile  His Ile Asn Thr Thr  His Asn Ser Phe Gly  Met Gln Ser 
    4580                 4585                 4590             


Tyr Ile  Val Asn Gln Leu Lys  Pro Phe His Arg Tyr  Glu Ile Arg 
    4595                 4600                 4605             


Ile Gln  Ala Cys Thr Thr Leu  Gly Cys Ala Ser Ser  Asp Trp Thr 
    4610                 4615                 4620             


Phe Ile  Gln Thr Pro Glu Ile  Ala Pro Leu Met Gln  Pro Pro Pro 
    4625                 4630                 4635             


His Leu  Glu Val Gln Met Ala  Pro Gly Gly Phe Gln  Pro Thr Val 
    4640                 4645                 4650             


Ser Leu  Leu Trp Thr Gly Pro  Leu Gln Pro Asn Gly  Lys Val Leu 
    4655                 4660                 4665             


Tyr Tyr  Glu Leu Tyr Arg Arg  Gln Ile Ala Thr Gln  Pro Arg Lys 
    4670                 4675                 4680             


Ser Asn  Pro Val Leu Ile Tyr  Asn Gly Ser Ser Thr  Ser Phe Ile 
    4685                 4690                 4695             


Asp Ser  Glu Leu Leu Pro Phe  Thr Glu Tyr Glu Tyr  Gln Val Trp 
    4700                 4705                 4710             


Ala Val  Asn Ser Ala Gly Lys  Ala Pro Ser Ser Trp  Thr Trp Cys 
    4715                 4720                 4725             


Arg Thr  Gly Pro Ala Pro Pro  Glu Gly Leu Arg Ala  Pro Thr Phe 
    4730                 4735                 4740             


His Val  Ile Ser Ser Thr Gln  Ala Val Val Asn Ile  Ser Ala Pro 
    4745                 4750                 4755             


Gly Lys  Pro Asn Gly Ile Val  Ser Leu Tyr Arg Leu  Phe Ser Ser 
    4760                 4765                 4770             


Ser Ala  His Gly Ala Glu Thr  Val Leu Ser Glu Gly  Met Ala Thr 
    4775                 4780                 4785             


Gln Gln  Thr Leu His Gly Leu  Gln Ala Phe Thr Asn  Tyr Ser Ile 
    4790                 4795                 4800             


Gly Val  Glu Ala Cys Thr Cys  Phe Asn Cys Cys Ser  Lys Gly Pro 
    4805                 4810                 4815             


Thr Ala  Glu Leu Arg Thr His  Pro Ala Pro Pro Ser  Gly Leu Ser 
    4820                 4825                 4830             


Ser Pro  Gln Ile Gly Thr Leu  Ala Ser Arg Thr Ala  Ser Phe Arg 
    4835                 4840                 4845             


Trp Ser  Pro Pro Met Phe Pro  Asn Gly Val Ile His  Ser Tyr Glu 
    4850                 4855                 4860             


Leu Gln  Phe His Val Ala Cys  Pro Pro Asp Ser Ala  Leu Pro Cys 
    4865                 4870                 4875             


Thr Pro  Ser Gln Ile Glu Thr  Lys Tyr Thr Gly Leu  Gly Gln Lys 
    4880                 4885                 4890             


Ala Ser  Leu Gly Gly Leu Gln  Pro Tyr Thr Thr Tyr  Lys Leu Arg 
    4895                 4900                 4905             


Val Val  Ala His Asn Glu Val  Gly Ser Thr Ala Ser  Glu Trp Ile 
    4910                 4915                 4920             


Ser Phe  Thr Thr Gln Lys Glu  Leu Pro Gln Tyr Arg  Ala Pro Phe 
    4925                 4930                 4935             


Ser Val  Asp Ser Asn Leu Ser  Val Val Cys Val Asn  Trp Ser Asp 
    4940                 4945                 4950             


Thr Phe  Leu Leu Asn Gly Gln  Leu Lys Glu Tyr Val  Leu Thr Asp 
    4955                 4960                 4965             


Gly Gly  Arg Arg Val Tyr Ser  Gly Leu Asp Thr Thr  Leu Tyr Ile 
    4970                 4975                 4980             


Pro Arg  Thr Ala Asp Lys Thr  Phe Phe Phe Gln Val  Ile Cys Thr 
    4985                 4990                 4995             


Thr Asp  Glu Gly Ser Val Lys  Thr Pro Leu Ile Gln  Tyr Asp Thr 
    5000                 5005                 5010             


Ser Thr  Gly Leu Gly Leu Val  Leu Thr Thr Pro Gly  Lys Lys Lys 
    5015                 5020                 5025             


Gly Ser  Arg Ser Lys Ser Thr  Glu Phe Tyr Ser Glu  Leu Trp Phe 
    5030                 5035                 5040             


Ile Val  Leu Met Ala Met Leu  Gly Leu Ile Leu Leu  Ala Ile Phe 
    5045                 5050                 5055             


Leu Ser  Leu Ile Leu Gln Arg  Lys Ile His Lys Glu  Pro Tyr Ile 
    5060                 5065                 5070             


Arg Glu  Arg Pro Pro Leu Val  Pro Leu Gln Lys Arg  Met Ser Pro 
    5075                 5080                 5085             


Leu Asn  Val Tyr Pro Pro Gly  Glu Asn His Met Gly  Leu Ala Asp 
    5090                 5095                 5100             


Thr Lys  Ile Pro Arg Ser Gly  Thr Pro Val Ser Ile  Arg Ser Asn 
    5105                 5110                 5115             


Arg Ser  Ala Cys Val Leu Arg  Ile Pro Ser Gln Asn  Gln Thr Ser 
    5120                 5125                 5130             


Leu Thr  Tyr Ser Gln Gly Ser  Leu His Arg Ser Val  Ser Gln Leu 
    5135                 5140                 5145             


Met Asp  Ile Gln Asp Lys Lys  Val Leu Met Asp Asn  Ser Leu Trp 
    5150                 5155                 5160             


Glu Ala  Ile Met Gly His Asn  Ser Gly Leu Tyr Val  Asp Glu Glu 
    5165                 5170                 5175             


Asp Leu  Met Asn Ala Ile Lys  Asp Phe Ser Ser Val  Thr Lys Glu 
    5180                 5185                 5190             


Arg Thr  Thr Phe Thr Asp Thr  His Leu 
    5195                 5200         


<210>  39
<211>  410
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(410)
<223>  NR2E3 (photoreceptor-specific nuclear receptor), isoform long

<400>  39

Met Glu Thr Arg Pro Thr Ala Leu Met Ser Ser Thr Val Ala Ala Ala 
1               5                   10                  15      


Ala Pro Ala Ala Gly Ala Ala Ser Arg Lys Glu Ser Pro Gly Arg Trp 
            20                  25                  30          


Gly Leu Gly Glu Asp Pro Thr Gly Val Ser Pro Ser Leu Gln Cys Arg 
        35                  40                  45              


Val Cys Gly Asp Ser Ser Ser Gly Lys His Tyr Gly Ile Tyr Ala Cys 
    50                  55                  60                  


Asn Gly Cys Ser Gly Phe Phe Lys Arg Ser Val Arg Arg Arg Leu Ile 
65                  70                  75                  80  


Tyr Arg Cys Gln Val Gly Ala Gly Met Cys Pro Val Asp Lys Ala His 
                85                  90                  95      


Arg Asn Gln Cys Gln Ala Cys Arg Leu Lys Lys Cys Leu Gln Ala Gly 
            100                 105                 110         


Met Asn Gln Asp Ala Val Gln Asn Glu Arg Gln Pro Arg Ser Thr Ala 
        115                 120                 125             


Gln Val His Leu Asp Ser Met Glu Ser Asn Thr Glu Ser Arg Pro Glu 
    130                 135                 140                 


Ser Leu Val Ala Pro Pro Ala Pro Ala Gly Arg Ser Pro Arg Gly Pro 
145                 150                 155                 160 


Thr Pro Met Ser Ala Ala Arg Ala Leu Gly His His Phe Met Ala Ser 
                165                 170                 175     


Leu Ile Thr Ala Glu Thr Cys Ala Lys Leu Glu Pro Glu Asp Ala Asp 
            180                 185                 190         


Glu Asn Ile Asp Val Thr Ser Asn Asp Pro Glu Phe Pro Ser Ser Pro 
        195                 200                 205             


Tyr Ser Ser Ser Ser Pro Cys Gly Leu Asp Ser Ile His Glu Thr Ser 
    210                 215                 220                 


Ala Arg Leu Leu Phe Met Ala Val Lys Trp Ala Lys Asn Leu Pro Val 
225                 230                 235                 240 


Phe Ser Ser Leu Pro Phe Arg Asp Gln Val Ile Leu Leu Glu Glu Ala 
                245                 250                 255     


Trp Ser Glu Leu Phe Leu Leu Gly Ala Ile Gln Trp Ser Leu Pro Leu 
            260                 265                 270         


Asp Ser Cys Pro Leu Leu Ala Pro Pro Glu Ala Ser Ala Ala Gly Gly 
        275                 280                 285             


Ala Gln Gly Arg Leu Thr Leu Ala Ser Met Glu Thr Arg Val Leu Gln 
    290                 295                 300                 


Glu Thr Ile Ser Arg Phe Arg Ala Leu Ala Val Asp Pro Thr Glu Phe 
305                 310                 315                 320 


Ala Cys Met Lys Ala Leu Val Leu Phe Lys Pro Glu Thr Arg Gly Leu 
                325                 330                 335     


Lys Asp Pro Glu His Val Glu Ala Leu Gln Asp Gln Ser Gln Val Met 
            340                 345                 350         


Leu Ser Gln His Ser Lys Ala His His Pro Ser Gln Pro Val Arg Phe 
        355                 360                 365             


Gly Lys Leu Leu Leu Leu Leu Pro Ser Leu Arg Phe Ile Thr Ala Glu 
    370                 375                 380                 


Arg Ile Glu Leu Leu Phe Phe Arg Lys Thr Ile Gly Asn Thr Pro Met 
385                 390                 395                 400 


Glu Lys Leu Leu Cys Asp Met Phe Lys Asn 
                405                 410 


<210>  40
<211>  1250
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1250)
<223>  human CNGB1 protein (NGS)

<400>  40

Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Thr Pro 
1               5                   10                  15      


Arg Lys Thr Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          


Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Thr 
        35                  40                  45              


Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  


Ala Val Ala Asp Pro Ser Pro Gln Glu Thr Lys Glu Ala Ala Leu Thr 
65                  70                  75                  80  


Ser Thr Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      


Ser Pro Ser His Arg Val Leu Thr Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         


Val Ile Pro Gln Pro Val His Ser Ile Thr Glu Asp Pro Ala Gln Ile 
        115                 120                 125             


Leu Gly His Gly Ser Thr Gly Asp Thr Gly Cys Thr Asp Glu Pro Asn 
    130                 135                 140                 


Glu Ala Leu Glu Ala Gln Asp Thr Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     


Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Thr Gly Ala Ala Ser 
            180                 185                 190         


Asp Pro Ala Pro Pro Gly Arg Pro Gln Glu Met Gly Pro Lys Leu Gln 
        195                 200                 205             


Ala Arg Glu Thr Pro Ser Leu Pro Thr Pro Ile Pro Leu Gln Pro Lys 
    210                 215                 220                 


Glu Glu Pro Lys Glu Ala Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln 
225                 230                 235                 240 


Ala Gln Thr Ser Ser Leu Pro Pro Thr Arg Asp Pro Ala Arg Leu Val 
                245                 250                 255     


Ala Trp Val Leu His Arg Leu Glu Met Ala Leu Pro Gln Pro Val Leu 
            260                 265                 270         


His Gly Lys Ile Gly Glu Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp 
        275                 280                 285             


Val Gln Thr Ile Ser Ile Leu Pro Gly Gly Gln Val Glu Pro Asp Leu 
    290                 295                 300                 


Val Leu Glu Glu Val Glu Pro Pro Trp Glu Asp Ala His Gln Asp Val 
305                 310                 315                 320 


Ser Thr Ser Pro Gln Gly Thr Glu Val Val Pro Ala Tyr Glu Glu Glu 
                325                 330                 335     


Asn Lys Ala Val Glu Lys Met Pro Arg Glu Leu Ser Arg Ile Glu Glu 
            340                 345                 350         


Glu Lys Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Val Thr Glu Val Leu Leu Asp Ser Cys Val Val Ser Gln 
    370                 375                 380                 


Val Gly Val Gly Gln Ser Glu Glu Asp Gly Thr Arg Pro Gln Ser Thr 
385                 390                 395                 400 


Ser Asp Gln Leu Trp Glu Glu Val Gly Glu Glu Ala Lys Lys Glu Ala 
                405                 410                 415     


Glu Glu Lys Ala Lys Glu Glu Ala Glu Glu Val Ala Glu Glu Glu Ala 
            420                 425                 430         


Glu Lys Glu Pro Gln Asp Trp Ala Glu Thr Lys Glu Glu Pro Glu Ala 
        435                 440                 445             


Glu Ala Glu Ala Ala Ser Ser Gly Val Pro Ala Thr Lys Gln His Pro 
    450                 455                 460                 


Glu Val Gln Val Glu Asp Thr Asp Ala Asp Ser Cys Pro Leu Met Ala 
465                 470                 475                 480 


Glu Glu Asn Pro Pro Ser Thr Val Leu Pro Pro Pro Ser Pro Ala Lys 
                485                 490                 495     


Ser Asp Thr Leu Ile Val Pro Ser Ser Ala Ser Gly Thr His Arg Lys 
            500                 505                 510         


Lys Leu Pro Ser Glu Asp Asp Glu Ala Glu Glu Leu Lys Ala Leu Ser 
        515                 520                 525             


Pro Ala Glu Ser Pro Val Val Ala Trp Ser Asp Pro Thr Thr Pro Lys 
    530                 535                 540                 


Asp Thr Asp Gly Gln Asp Arg Ala Ala Ser Thr Ala Ser Thr Asn Ser 
545                 550                 555                 560 


Ala Ile Ile Asn Asp Arg Leu Gln Glu Leu Val Lys Leu Phe Lys Glu 
                565                 570                 575     


Arg Thr Glu Lys Val Lys Glu Lys Leu Ile Asp Pro Asp Val Thr Ser 
            580                 585                 590         


Asp Glu Glu Ser Pro Lys Pro Ser Pro Ala Lys Lys Ala Pro Glu Pro 
        595                 600                 605             


Ala Pro Asp Thr Lys Pro Ala Glu Ala Glu Pro Val Glu Glu Glu His 
    610                 615                 620                 


Tyr Cys Asp Met Leu Cys Cys Lys Phe Lys His Arg Pro Trp Lys Lys 
625                 630                 635                 640 


Tyr Gln Phe Pro Gln Ser Ile Asp Pro Leu Thr Asn Leu Met Tyr Val 
                645                 650                 655     


Leu Trp Leu Phe Phe Val Val Met Ala Trp Asn Trp Asn Cys Trp Leu 
            660                 665                 670         


Ile Pro Val Arg Trp Ala Phe Pro Tyr Gln Thr Pro Asp Asn Ile His 
        675                 680                 685             


His Trp Leu Leu Met Asp Tyr Leu Cys Asp Leu Ile Tyr Phe Leu Asp 
    690                 695                 700                 


Ile Thr Val Phe Gln Thr Arg Leu Gln Phe Val Arg Gly Gly Asp Ile 
705                 710                 715                 720 


Ile Thr Asp Lys Lys Asp Met Arg Asn Asn Tyr Leu Lys Ser Arg Arg 
                725                 730                 735     


Phe Lys Met Asp Leu Leu Ser Leu Leu Pro Leu Asp Phe Leu Tyr Leu 
            740                 745                 750         


Lys Val Gly Val Asn Pro Leu Leu Arg Leu Pro Arg Cys Leu Lys Tyr 
        755                 760                 765             


Met Ala Phe Phe Glu Phe Asn Ser Arg Leu Glu Ser Ile Leu Ser Lys 
    770                 775                 780                 


Ala Tyr Val Tyr Arg Val Ile Arg Thr Thr Ala Tyr Leu Leu Tyr Ser 
785                 790                 795                 800 


Leu His Leu Asn Ser Cys Leu Tyr Tyr Trp Ala Ser Ala Tyr Gln Gly 
                805                 810                 815     


Leu Gly Ser Thr His Trp Val Tyr Asp Gly Val Gly Asn Ser Tyr Ile 
            820                 825                 830         


Arg Cys Tyr Tyr Phe Ala Val Lys Thr Leu Ile Thr Ile Gly Gly Leu 
        835                 840                 845             


Pro Asp Pro Lys Thr Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Tyr 
    850                 855                 860                 


Phe Thr Gly Val Phe Ala Phe Ser Val Met Ile Gly Gln Met Arg Asp 
865                 870                 875                 880 


Val Val Gly Ala Ala Thr Ala Gly Gln Thr Tyr Tyr Arg Ser Cys Met 
                885                 890                 895     


Asp Ser Thr Val Lys Tyr Met Asn Phe Tyr Lys Ile Pro Lys Ser Val 
            900                 905                 910         


Gln Asn Arg Val Lys Thr Trp Tyr Glu Tyr Thr Trp His Ser Gln Gly 
        915                 920                 925             


Met Leu Asp Glu Ser Glu Leu Met Val Gln Leu Pro Asp Lys Met Arg 
    930                 935                 940                 


Leu Asp Leu Ala Ile Asp Val Asn Tyr Asn Ile Val Ser Lys Val Ala 
945                 950                 955                 960 


Leu Phe Gln Gly Cys Asp Arg Gln Met Ile Phe Asp Met Leu Lys Arg 
                965                 970                 975     


Leu Arg Ser Val Val Tyr Leu Pro Asn Asp Tyr Val Cys Lys Lys Gly 
            980                 985                 990         


Glu Ile Gly Arg Glu Met Tyr Ile  Ile Gln Ala Gly Gln  Val Gln Val 
        995                 1000                 1005             


Leu Gly  Gly Pro Asp Gly Lys  Ser Val Leu Val Thr  Leu Lys Ala 
    1010                 1015                 1020             


Gly Ser  Val Phe Gly Glu Ile  Ser Leu Leu Ala Val  Gly Gly Gly 
    1025                 1030                 1035             


Asn Arg  Arg Thr Ala Asn Val  Val Ala His Gly Phe  Thr Asn Leu 
    1040                 1045                 1050             


Phe Ile  Leu Asp Lys Lys Asp  Leu Asn Glu Ile Leu  Val His Tyr 
    1055                 1060                 1065             


Pro Glu  Ser Gln Lys Leu Leu  Arg Lys Lys Ala Arg  Arg Met Leu 
    1070                 1075                 1080             


Arg Ser  Asn Asn Lys Pro Gln  Glu Glu Lys Ser Val  Leu Ile Leu 
    1085                 1090                 1095             


Pro Pro  Arg Ala Gly Thr Pro  Lys Leu Phe Asn Ala  Ala Leu Ala 
    1100                 1105                 1110             


Met Thr  Gly Lys Met Gly Gly  Lys Gly Ala Lys Gly  Gly Lys Leu 
    1115                 1120                 1125             


Ala His  Leu Arg Ala Arg Leu  Lys Glu Leu Ala Ala  Leu Glu Ala 
    1130                 1135                 1140             


Ala Ala  Lys Gln Gln Glu Leu  Val Glu Gln Ala Lys  Ser Ser Gln 
    1145                 1150                 1155             


Asp Val  Lys Gly Glu Glu Gly  Ser Ala Ala Pro Asp  Gln His Thr 
    1160                 1165                 1170             


His Pro  Lys Glu Ala Ala Thr  Asp Pro Pro Ala Pro  Arg Thr Pro 
    1175                 1180                 1185             


Pro Glu  Pro Pro Gly Ser Pro  Pro Ser Ser Pro Pro  Pro Ala Ser 
    1190                 1195                 1200             


Leu Gly  Arg Pro Glu Gly Glu  Glu Glu Gly Pro Ala  Glu Pro Glu 
    1205                 1210                 1215             


Glu His  Ser Val Arg Ile Cys  Met Ser Pro Gly Pro  Glu Pro Gly 
    1220                 1225                 1230             


Glu Gln  Ile Leu Ser Val Lys  Met Pro Glu Glu Arg  Glu Glu Lys 
    1235                 1240                 1245             


Ala Glu  
    1250 


<210>  41
<211>  1251
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1251)
<223>  human CNGB1 protein (GenBank)

<400>  41

Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Thr Pro 
1               5                   10                  15      


Arg Lys Thr Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          


Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Thr 
        35                  40                  45              


Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  


Ala Val Ala Asp Pro Ser Pro Gln Glu Thr Lys Glu Ala Ala Leu Thr 
65                  70                  75                  80  


Ser Thr Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      


Ser Pro Ser Arg Arg Val Leu Thr Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         


Val Ile Pro Gln Pro Val His Ser Ile Thr Glu Asp Pro Ala Gln Ile 
        115                 120                 125             


Leu Gly His Gly Ser Thr Gly Asp Thr Gly Cys Thr Asp Glu Pro Asn 
    130                 135                 140                 


Glu Ala Leu Glu Ala Gln Asp Thr Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     


Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Thr Gly Ala Ala Ser 
            180                 185                 190         


Asp Pro Ala Pro Pro Gly Arg Pro Gln Glu Met Gly Pro Lys Leu Gln 
        195                 200                 205             


Ala Arg Glu Thr Pro Ser Leu Pro Thr Pro Ile Pro Leu Gln Pro Lys 
    210                 215                 220                 


Glu Glu Pro Lys Glu Ala Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln 
225                 230                 235                 240 


Ala Gln Thr Ser Ser Leu Pro Pro Thr Arg Asp Pro Ala Arg Leu Val 
                245                 250                 255     


Ala Trp Val Leu His Arg Leu Glu Met Ala Leu Pro Gln Pro Val Leu 
            260                 265                 270         


His Gly Lys Ile Gly Glu Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp 
        275                 280                 285             


Val Gln Thr Ile Ser Ile Leu Pro Gly Gly Gln Val Glu Pro Asp Leu 
    290                 295                 300                 


Val Leu Glu Glu Val Glu Pro Pro Trp Glu Asp Ala His Gln Asp Val 
305                 310                 315                 320 


Ser Thr Ser Pro Gln Gly Thr Glu Val Val Pro Ala Tyr Glu Glu Glu 
                325                 330                 335     


Asn Lys Ala Val Glu Lys Met Pro Arg Glu Leu Ser Arg Ile Glu Glu 
            340                 345                 350         


Glu Lys Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Val Thr Glu Val Leu Leu Asp Ser Cys Val Val Ser Gln 
    370                 375                 380                 


Val Gly Val Gly Gln Ser Glu Glu Asp Gly Thr Arg Pro Gln Ser Thr 
385                 390                 395                 400 


Ser Asp Gln Lys Leu Trp Glu Glu Val Gly Glu Glu Ala Lys Lys Glu 
                405                 410                 415     


Ala Glu Glu Lys Ala Lys Glu Glu Ala Glu Glu Val Ala Glu Glu Glu 
            420                 425                 430         


Ala Glu Lys Glu Pro Gln Asp Trp Ala Glu Thr Lys Glu Glu Pro Glu 
        435                 440                 445             


Ala Glu Ala Glu Ala Ala Ser Ser Gly Val Pro Ala Thr Lys Gln His 
    450                 455                 460                 


Pro Glu Val Gln Val Glu Asp Thr Asp Ala Asp Ser Cys Pro Leu Met 
465                 470                 475                 480 


Ala Glu Glu Asn Pro Pro Ser Thr Val Leu Pro Pro Pro Ser Pro Ala 
                485                 490                 495     


Lys Ser Asp Thr Leu Ile Val Pro Ser Ser Ala Ser Gly Thr His Arg 
            500                 505                 510         


Lys Lys Leu Pro Ser Glu Asp Asp Glu Ala Glu Glu Leu Lys Ala Leu 
        515                 520                 525             


Ser Pro Ala Glu Ser Pro Val Val Ala Trp Ser Asp Pro Thr Thr Pro 
    530                 535                 540                 


Lys Asp Thr Asp Gly Gln Asp Arg Ala Ala Ser Thr Ala Ser Thr Asn 
545                 550                 555                 560 


Ser Ala Ile Ile Asn Asp Arg Leu Gln Glu Leu Val Lys Leu Phe Lys 
                565                 570                 575     


Glu Arg Thr Glu Lys Val Lys Glu Lys Leu Ile Asp Pro Asp Val Thr 
            580                 585                 590         


Ser Asp Glu Glu Ser Pro Lys Pro Ser Pro Ala Lys Lys Ala Pro Glu 
        595                 600                 605             


Pro Ala Pro Asp Thr Lys Pro Ala Glu Ala Glu Pro Val Glu Glu Glu 
    610                 615                 620                 


His Tyr Cys Asp Met Leu Cys Cys Lys Phe Lys His Arg Pro Trp Lys 
625                 630                 635                 640 


Lys Tyr Gln Phe Pro Gln Ser Ile Asp Pro Leu Thr Asn Leu Met Tyr 
                645                 650                 655     


Val Leu Trp Leu Phe Phe Val Val Met Ala Trp Asn Trp Asn Cys Trp 
            660                 665                 670         


Leu Ile Pro Val Arg Trp Ala Phe Pro Tyr Gln Thr Pro Asp Asn Ile 
        675                 680                 685             


His His Trp Leu Leu Met Asp Tyr Leu Cys Asp Leu Ile Tyr Phe Leu 
    690                 695                 700                 


Asp Ile Thr Val Phe Gln Thr Arg Leu Gln Phe Val Arg Gly Gly Asp 
705                 710                 715                 720 


Ile Ile Thr Asp Lys Lys Asp Met Arg Asn Asn Tyr Leu Lys Ser Arg 
                725                 730                 735     


Arg Phe Lys Met Asp Leu Leu Ser Leu Leu Pro Leu Asp Phe Leu Tyr 
            740                 745                 750         


Leu Lys Val Gly Val Asn Pro Leu Leu Arg Leu Pro Arg Cys Leu Lys 
        755                 760                 765             


Tyr Met Ala Phe Phe Glu Phe Asn Ser Arg Leu Glu Ser Ile Leu Ser 
    770                 775                 780                 


Lys Ala Tyr Val Tyr Arg Val Ile Arg Thr Thr Ala Tyr Leu Leu Tyr 
785                 790                 795                 800 


Ser Leu His Leu Asn Ser Cys Leu Tyr Tyr Trp Ala Ser Ala Tyr Gln 
                805                 810                 815     


Gly Leu Gly Ser Thr His Trp Val Tyr Asp Gly Val Gly Asn Ser Tyr 
            820                 825                 830         


Ile Arg Cys Tyr Tyr Phe Ala Val Lys Thr Leu Ile Thr Ile Gly Gly 
        835                 840                 845             


Leu Pro Asp Pro Lys Thr Leu Phe Glu Ile Val Phe Gln Leu Leu Asn 
    850                 855                 860                 


Tyr Phe Thr Gly Val Phe Ala Phe Ser Val Met Ile Gly Gln Met Arg 
865                 870                 875                 880 


Asp Val Val Gly Ala Ala Thr Ala Gly Gln Thr Tyr Tyr Arg Ser Cys 
                885                 890                 895     


Met Asp Ser Thr Val Lys Tyr Met Asn Phe Tyr Lys Ile Pro Lys Ser 
            900                 905                 910         


Val Gln Asn Arg Val Lys Thr Trp Tyr Glu Tyr Thr Trp His Ser Gln 
        915                 920                 925             


Gly Met Leu Asp Glu Ser Glu Leu Met Val Gln Leu Pro Asp Lys Met 
    930                 935                 940                 


Arg Leu Asp Leu Ala Ile Asp Val Asn Tyr Asn Ile Val Ser Lys Val 
945                 950                 955                 960 


Ala Leu Phe Gln Gly Cys Asp Arg Gln Met Ile Phe Asp Met Leu Lys 
                965                 970                 975     


Arg Leu Arg Ser Val Val Tyr Leu Pro Asn Asp Tyr Val Cys Lys Lys 
            980                 985                 990         


Gly Glu Ile Gly Arg Glu Met Tyr  Ile Ile Gln Ala Gly  Gln Val Gln 
        995                 1000                 1005             


Val Leu  Gly Gly Pro Asp Gly  Lys Ser Val Leu Val  Thr Leu Lys 
    1010                 1015                 1020             


Ala Gly  Ser Val Phe Gly Glu  Ile Ser Leu Leu Ala  Val Gly Gly 
    1025                 1030                 1035             


Gly Asn  Arg Arg Thr Ala Asn  Val Val Ala His Gly  Phe Thr Asn 
    1040                 1045                 1050             


Leu Phe  Ile Leu Asp Lys Lys  Asp Leu Asn Glu Ile  Leu Val His 
    1055                 1060                 1065             


Tyr Pro  Glu Ser Gln Lys Leu  Leu Arg Lys Lys Ala  Arg Arg Met 
    1070                 1075                 1080             


Leu Arg  Ser Asn Asn Lys Pro  Lys Glu Glu Lys Ser  Val Leu Ile 
    1085                 1090                 1095             


Leu Pro  Pro Arg Ala Gly Thr  Pro Lys Leu Phe Asn  Ala Ala Leu 
    1100                 1105                 1110             


Ala Met  Thr Gly Lys Met Gly  Gly Lys Gly Ala Lys  Gly Gly Lys 
    1115                 1120                 1125             


Leu Ala  His Leu Arg Ala Arg  Leu Lys Glu Leu Ala  Ala Leu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Lys Gln Gln Glu  Leu Val Glu Gln Ala  Lys Ser Ser 
    1145                 1150                 1155             


Gln Asp  Val Lys Gly Glu Glu  Gly Ser Ala Ala Pro  Asp Gln His 
    1160                 1165                 1170             


Thr His  Pro Lys Glu Ala Ala  Thr Asp Pro Pro Ala  Pro Arg Thr 
    1175                 1180                 1185             


Pro Pro  Glu Pro Pro Gly Ser  Pro Pro Ser Ser Pro  Pro Pro Ala 
    1190                 1195                 1200             


Ser Leu  Gly Arg Pro Glu Gly  Glu Glu Glu Gly Pro  Ala Glu Pro 
    1205                 1210                 1215             


Glu Glu  His Ser Val Arg Ile  Cys Met Ser Pro Gly  Pro Glu Pro 
    1220                 1225                 1230             


Gly Glu  Gln Ile Leu Ser Val  Lys Met Pro Glu Glu  Arg Glu Glu 
    1235                 1240                 1245             


Lys Ala  Glu 
    1250     


<210>  42
<211>  4651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'ITR-hRHO promoter-CNGB1a-SV40polyA-3'ITR

<400>  42
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagcctct cctccctgac ctcaggcttc ctcctagtgt      240

caccttggcc cctcttagaa gccaattagg ccctcagttt ctgcagcggg gattaatatg      300

attatgaaca cccccaatct cccagatgct gattcagcca ggagcttagg agggggaggt      360

cactttataa gggtctgggg gggtcagaac ccagagtcat cactagtaac ggccgccagt      420

gtgctggaat tcgcccttct ccaccgccat gttgggctgg gtccagaggg tgctgcctca      480

gcccccaggg acccctcgga agaccaagat gcaggaggaa gaggaagtgg aaccagagcc      540

agagatggag gcggaggtgg aaccagaacc gaatcctgag gaggccgaga cagagtccga      600

gtccatgccc cccgaagagt cattcaagga ggaggaagtg gctgtggcag acccaagccc      660

tcaggagacc aaggaggctg cccttacttc caccatatcc ctccgggccc agggcgctga      720

gatttctgaa atgaatagtc ccagccacag ggtactgacc tggctcatga agggtgtaga      780

gaaggtgatc ccgcagcctg ttcacagcat cacggaggac ccggctcaga tcctggggca      840

tggcagcact ggggacacag ggtgcacaga tgaacccaat gaggcccttg aggcccaaga      900

cactaggcct gggctgcggc tgcttctgtg gctggagcag aatctggaaa gagtgcttcc      960

tcagcccccc aaatcctctg aggtctggag agatgagcct gcagttgcta cagcgcctcc     1020

aggacgcccc caggaaatgg ggcccaagct gcaggcccgg gagaccccct ccctgcccac     1080

acccatcccc ctgcagccca aggaggaacc caaggaggca ccagctccag agccccagcc     1140

cggctcccag gcccagacct cctccctgcc accaaccagg gaccctgcca ggctggtggc     1200

atgggtcctg cacaggctgg agatggcctt gccgcagcca gtgctacatg ggaaaatagg     1260

ggaacaggag cctgactccc ctgggatatg tgatgtgcag accatcagca tccttcctgg     1320

aggacaagtg gagcctgacc ttgtcctaga ggaggttgaa ccgccctggg aggatgccca     1380

ccaggatgtc agtaccagcc cacagggtac agaggtggtt ccagcttatg aagaagagaa     1440

caaagctgtg gagaagatgc ccagagagct gtcccggatt gaagaggaga aagaagatga     1500

ggaggaggaa gaggaagagg aggaggagga ggaagaggag gaggtgactg aggtgctgct     1560

ggatagctgt gtggtgtcgc aggtgggcgt gggccagagt gaagaagacg ggacccggcc     1620

ccagagcact tcagatcaga agctgtggga ggaagttggg gaggaggcca agaaggaggc     1680

tgaagagaag gccaaggagg aggccgagga ggtggctgaa gaggaggctg aaaaggagcc     1740

ccaggactgg gcggagacca aggaggagcc tgaggctgag gccgaggctg ccagttcagg     1800

agtgcctgcc acgaaacagc acccagaagt gcaggtggaa gatactgatg ctgatagctg     1860

ccccctcatg gcagaagaga atccaccctc aaccgtgttg ccgccaccat ctcctgccaa     1920

atcagacacc cttatagtcc caagctcagc ctcggggaca cacaggaaga agctgccctc     1980

tgaggatgat gaggctgaag agctcaaggc gttgtcacca gcagagtccc cagtggttgc     2040

ctggtctgac cccaccaccc cgaaggacac tgatggccag gaccgtgcgg cctccacggc     2100

cagcacaaat agcgccatca tcaacgaccg gctccaggag ctggtgaagc tcttcaagga     2160

gcggacagag aaagtgaagg agaaactcat tgaccctgac gtcacctctg atgaggagag     2220

ccccaagccc tccccagcca agaaagcccc agagccagct ccagacacaa agcccgctga     2280

agccgagcca gtggaagagg agcactattg cgacatgctc tgctgcaagt tcaaacaccg     2340

cccctggaag aagtaccagt ttccccagag cattgacccg ctgaccaacc tgatgtatgt     2400

cctatggctg ttcttcgtgg tgatggcctg gaattggaac tgttggctga ttcccgtgcg     2460

ctgggccttc ccctaccaga ccccggacaa catccaccac tggctgctga tggattacct     2520

atgcgacctc atctacttcc tggacatcac cgtgttccag acacgcctgc agtttgtcag     2580

aggcggggac atcattacgg acaaaaagga catgcgaaat aactacctga agtctcgccg     2640

cttcaagatg gacctgctca gcctcctgcc cttggatttt ctctatttga aagtcggtgt     2700

gaaccccctc ctccgcctgc cccgctgttt aaagtacatg gccttcttcg agtttaacag     2760

ccgcctggaa tccatcctca gcaaagccta cgtgtacagg gtcatcagga ccacagccta     2820

ccttctctac agcctgcatt tgaattcctg tctttattac tgggcatcgg cctatcaggg     2880

cctcggctcc actcactggg tttacgatgg cgtgggaaac agttatattc gctgttacta     2940

ctttgctgtg aagaccctca tcaccatcgg ggggctgcct gaccccaaga cactctttga     3000

aattgtcttc cagctgctga attatttcac gggcgtcttt gctttctctg tgatgatcgg     3060

acagatgaga gatgtggtag gggccgccac cgcgggacag acctactacc gcagctgcat     3120

ggacagcacg gtgaagtaca tgaatttcta caagatcccc aagtccgtgc agaaccgcgt     3180

caagacctgg tacgagtaca cctggcactc gcaaggcatg ctggatgagt cagagctgat     3240

ggtgcagctt ccagacaaga tgcggctgga cctcgccatc gacgtgaact acaacatcgt     3300

tagcaaagtc gcactctttc agggctgtga ccggcagatg atctttgaca tgctgaagag     3360

gcttcgctct gttgtctacc tgcccaacga ctatgtgtgc aagaaggggg agatcggccg     3420

tgagatgtac atcatccagg cagggcaagt gcaggtcttg ggcggccctg atgggaaatc     3480

tgtgctggtg acgctgaaag ctggatctgt gtttggagaa ataagcttgc tggctgttgg     3540

gggcgggaac cggcgcacgg ccaacgtggt ggcgcacggg tttaccaacc tcttcatcct     3600

ggataagaag gacctgaatg agattttggt gcattatcct gagtctcaga agttactccg     3660

gaagaaagcc aggcgcatgc tgagaagcaa caataagccc aaggaggaga agagcgtgct     3720

gatccttcca ccccgggcgg gcaccccaaa gctcttcaac gctgccctcg ctatgacagg     3780

aaagatgggt ggcaaggggg caaaaggcgg caaacttgct cacctccggg cccggctcaa     3840

agaactggcc gcgctggagg cggctgcaaa gcagcaagag ttggtggaac aggccaagag     3900

ctcgcaagac gtcaagggag aggaaggctc cgccgcccca gaccagcaca cgcacccaaa     3960

ggaggccgcc accgacccac ccgcgccccg gacgcccccc gagcccccgg ggtctccacc     4020

gagctctcca ccgcctgcct cccttgggag gccggaggga gaggaggagg ggccggccga     4080

gcccgaagag cactcggtga ggatctgcat gagcccgggc ccggagccgg gagagcagat     4140

cctgtcggtg aagatgccgg aggaaaggga ggagaaggcg gagtaaggtg gggtgaggcg     4200

gatccatggc cgcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa     4260

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     4320

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     4380

agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtactcgag     4440

ttaagggcga attcccgata aggatcttcc tagagcatgg ctacgtagat aagtagcatg     4500

gcgggttaat cattaactac aaggaacccc tagtgatgga gttggccact ccctctctgc     4560

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc     4620

gggcggcctc agtgagcgag cgagcgcgca g                                    4651


<210>  43
<211>  4665
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'ITR-hRHO promoter-CNGB1a-SV40polyA-3'ITR (NGS)

<400>  43
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagcctct cctccctgac ctcaggcttc ctcctagtgt      240

caccttggcc cctcttagaa gccaattagg ccctcagttt ctgcagcggg gattaatatg      300

attatgaaca cccccaatct cccagatgct gattcagcca ggagcttagg agggggaggt      360

cactttataa gggtctgggg gggtcagaac ccagagtcat cactagtaac ggccgccagt      420

gtgctggaat tcgcccttct ccaccgccat gttgggctgg gtccagaggg tgctgcctca      480

gcccccaggg acccctcgga agaccaagat gcaggaggaa gaggaagtgg aaccagagcc      540

agagatggag gcggaggtgg aaccagaacc gaatcctgag gaggccgaga cagagtccga      600

gtccatgccc cccgaagagt cattcaagga ggaggaagtg gctgtggcag acccaagccc      660

tcaggagacc aaggaggctg cccttacttc caccatatcc ctccgggccc agggcgctga      720

gatttctgaa atgaatagtc ccagccacag ggtactgacc tggctcatga agggtgtaga      780

gaaggtgatc ccgcagcctg ttcacagcat cacggaggac ccggctcaga tcctggggca      840

tggcagcact ggggacacag ggtgcacaga tgaacccaat gaggcccttg aggcccaaga      900

cactaggcct gggctgcggc tgcttctgtg gctggagcag aatctggaaa gagtgcttcc      960

tcagcccccc aaatcctctg aggtctggag agatgagcct gcagttgcta caggtgctgc     1020

ctcagaccca gcgcctccag gacgccccca ggaaatgggg cccaagctgc aggcccggga     1080

gaccccctcc ctgcccacac ccatccccct gcagcccaag gaggaaccca aggaggcacc     1140

agctccagag ccccagcccg gctcccaggc ccagacctcc tccctgccac caaccaggga     1200

ccctgccagg ctggtggcat gggtcctgca caggctggag atggccttgc cgcagccagt     1260

gctacatggg aaaatagggg aacaggagcc tgactcccct gggatatgtg atgtgcagac     1320

catcagcatc cttcctggag gacaagtgga gcctgacctt gtcctagagg aggttgaacc     1380

gccctgggag gatgcccacc aggatgtcag taccagccca cagggtacag aggtggttcc     1440

agcttatgaa gaagagaaca aagctgtgga gaagatgccc agagagctgt cccggattga     1500

agaggagaaa gaagatgagg aggaggaaga ggaagaggag gaggaggagg aagaggagga     1560

ggtgactgag gtgctgctgg atagctgtgt ggtgtcgcag gtgggcgtgg gccagagtga     1620

agaagacggg acccggcccc agagcacttc agatcagctg tgggaggaag ttggggagga     1680

ggccaagaag gaggctgaag agaaggccaa ggaggaggcc gaggaggtgg ctgaagagga     1740

ggctgaaaag gagccccagg actgggcgga gaccaaggag gagcctgagg ctgaggccga     1800

ggctgccagt tcaggagtgc ctgccacgaa acagcaccca gaagtgcagg tggaagatac     1860

tgatgctgat agctgccccc tcatggcaga agagaatcca ccctcaaccg tgttgccgcc     1920

accgtctcct gccaaatcag acacccttat agtcccaagc tcagcctcgg ggacacacag     1980

gaagaagctg ccctctgagg atgatgaggc tgaagagctc aaggcgttgt caccagcaga     2040

gtccccagtg gttgcctggt ctgaccccac caccccgaag gacactgatg gccaggaccg     2100

tgcggcctcc acggccagca caaatagcgc catcatcaac gaccggctcc aggagctggt     2160

gaagctcttc aaggagcgga cagagaaagt gaaggagaaa ctcattgacc ctgacgtcac     2220

ctctgatgag gagagcccca agccctcccc agccaagaaa gccccagagc cagctccaga     2280

cacaaagccc gctgaagccg agccagtgga agaggagcac tattgcgaca tgctctgctg     2340

caagttcaaa caccgcccct ggaagaagta ccagtttccc cagagcattg acccgctgac     2400

caacctgatg tatgtcctat ggctgttctt cgtggtgatg gcctggaatt ggaactgttg     2460

gctgattccc gtgcgctggg ccttccccta ccagaccccg gacaacatcc accactggct     2520

gctgatggat tacctatgcg acctcatcta cttcctggac atcaccgtgt tccagacacg     2580

cctgcagttt gtcagaggcg gggacatcat tacggacaaa aaggacatgc gaaataatta     2640

cctgaagtct cgccgcttca agatggacct gctcagcctc ctgcccttgg attttctcta     2700

tttgaaagtc ggtgtgaacc ccctcctccg cctgccccgc tgtttaaagt acatggcctt     2760

cttcgagttt aacagccgcc tggaatccat cctcagcaaa gcctacgtgt acagggtcat     2820

caggaccaca gcctaccttc tctacagcct gcatttgaat tcctgtcttt attactgggc     2880

atcggcctat cagggcctcg gctccactca ctgggtttac gatggcgtgg gaaacagtta     2940

tattcgctgt tactactttg ctgtgaagac cctcatcacc atcggggggc tgcctgaccc     3000

caagacactc tttgaaattg tcttccagct gctgaattat ttcacgggcg tctttgcttt     3060

ctctgtgatg atcggacaga tgagagatgt ggtaggggcc gccaccgcgg gacagaccta     3120

ctaccgcagc tgcatggaca gcacggtgaa gtacatgaat ttctacaaga tccccaagtc     3180

cgtgcagaac cgcgtcaaga cctggtacga gtacacctgg cactcgcaag gcatgctgga     3240

tgagtcagag ctgatggtgc agcttccaga caagatgcgg ctggacctcg ccatcgacgt     3300

gaactacaac atcgttagca aagtcgcact ctttcagggc tgtgaccggc agatgatctt     3360

tgacatgctg aagaggcttc gctctgttgt ctacctgccc aacgactatg tgtgcaagaa     3420

gggggagatc ggccgtgaga tgtacatcat ccaggcaggg caagtgcagg tcttgggcgg     3480

ccctgatggg aaatctgtgc tggtgacgct gaaagctgga tctgtgtttg gagaaataag     3540

cttgctggct gttgggggcg ggaaccggcg cacggccaac gtggtggcgc acgggtttac     3600

caacctcttc atcctggata agaaggacct gaatgagatt ttggtgcatt atcctgagtc     3660

tcagaagtta ctccggaaga aagccaggcg catgctgaga agcaacaata agccccagga     3720

ggagaagagc gtgctgatcc ttccaccccg ggcgggcacc ccaaagctct tcaacgctgc     3780

cctcgctatg acaggaaaga tgggtggcaa gggggcaaaa ggcggcaaac ttgctcacct     3840

ccgggcccgg ctcaaagaac tggccgcgct ggaggcggct gcaaagcagc aagagttggt     3900

ggaacaggcc aagagctcgc aagacgtcaa gggagaggaa ggctccgccg ccccagacca     3960

gcacacgcac ccaaaggagg ccgccaccga cccacccgcg ccccggacgc cccccgagcc     4020

cccggggtct ccaccgagct ctccaccgcc tgcctccctt gggaggccgg agggagagga     4080

ggaggggccg gccgagcccg aagagcactc ggtgaggatc tgcatgagcc cgggcccgga     4140

gccgggagag cagatcctgt cggtgaagat gccggaggaa agggaggaga aggcggagta     4200

aggtggggtg aggcggatcc atggccgcag acatgataag atacattgat gagtttggac     4260

aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg     4320

ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt     4380

ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa aacctctaca     4440

aatgtggtct cgagttaagg gcgaattccc gataaggatc ttcctagagc atggctacgt     4500

agataagtag catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc     4560

cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg     4620

cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcag                     4665


<210>  44
<211>  4634
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'ITR-hRHO promoter-CNGB1a-SV40polyA-3'ITR (GenBank)

<400>  44
ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg       60

tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caactccatc actaggggtt cctcagatcg tagccatgct ctaggaagat cggaattcgc      180

ccttaagcct ctcctccctg acctcaggct tcctcctagt gtcaccttgg cccctcttag      240

aagccaatta ggccctcagt ttctgcagcg gggattaata tgattatgaa cacccccaat      300

ctcccagatg ctgattcagc caggagctta ggagggggag gtcactttat aagggtctgg      360

gggggtcaga acccagagtc atcactagta acggccgcca gtgtgctgga attcgccctt      420

ctccaccgcc atgttgggct gggtccagag ggtgctgcct cagcccccag ggacccctcg      480

gaagaccaag atgcaggagg aagaggaagt ggaaccagag ccagagatgg aggcggaggt      540

ggaaccagaa ccgaatcctg aggaggccga gacagagtcc gagtccatgc cccccgaaga      600

gtcattcaag gaggaggaag tggctgtggc agacccaagc cctcaggaga ccaaggaggc      660

tgcccttact tccaccatat ccctccgggc ccagggcgct gagatttctg aaatgaatag      720

tcccagccgc agggtactga cctggctcat gaagggtgta gagaaggtga tcccgcagcc      780

tgttcacagc atcacggagg acccggctca gatcctgggg catggcagca ctggggacac      840

agggtgcaca gatgaaccca atgaggccct tgaggcccaa gacactaggc ctgggctgcg      900

gctgcttctg tggctggagc agaatctgga aagagtgctt cctcagcccc ccaaatcctc      960

tgaggtctgg agagatgagc ctgcagttgc tacaggtgct gcctcagacc cagcgcctcc     1020

aggacgcccc caggaaatgg ggcccaagct gcaggcccgg gagaccccct ccctgcccac     1080

acccatcccc ctgcagccca aggaggaacc caaggaggca ccagctccag agccccagcc     1140

cggctcccag gcccagacct cctccctgcc accaaccagg gaccctgcca ggctggtggc     1200

atgggtcctg cacaggctgg agatggcctt gccgcagcca gtgctacatg ggaaaatagg     1260

ggaacaggag cctgactccc ctgggatatg tgatgtgcag accatcagca tccttcctgg     1320

aggacaagtg gagcctgacc ttgtcctaga ggaggttgaa ccgccctggg aggatgccca     1380

ccaggatgtc agtaccagcc cacagggtac agaggtggtt ccagcttatg aagaagagaa     1440

caaagctgtg gagaagatgc ccagagagct gtcccggatt gaagaggaga aagaagatga     1500

ggaggaggaa gaggaagagg aggaggagga ggaagaggag gaggtgactg aggtgctgct     1560

ggatagctgt gtggtgtcgc aggtgggcgt gggccagagt gaagaagacg ggacccggcc     1620

ccagagcact tcagatcaga agctgtggga ggaagttggg gaggaggcca agaaggaggc     1680

tgaagagaag gccaaggagg aggccgagga ggtggctgaa gaggaggctg aaaaggagcc     1740

ccaggactgg gcggagacca aggaggagcc tgaggctgag gccgaggctg ccagttcagg     1800

agtgcctgcc acgaaacagc acccagaagt gcaggtggaa gatactgatg ctgatagctg     1860

ccccctcatg gcagaagaga atccaccctc aaccgtgttg ccgccaccgt ctcctgccaa     1920

atcagacacc cttatagtcc caagctcagc ctcggggaca cacaggaaga agctgccctc     1980

tgaggatgat gaggctgaag agctcaaggc gttgtcacca gcagagtccc cagtggttgc     2040

ctggtctgac cccaccaccc cgaaggacac tgatggccag gaccgtgcgg cctccacggc     2100

cagcacaaat agcgccatca tcaacgaccg gctccaggag ctggtgaagc tcttcaagga     2160

gcggacagag aaagtgaagg agaaactcat tgaccctgac gtcacctctg atgaggagag     2220

ccccaagccc tccccagcca agaaagcccc agagccagct ccagacacaa agcccgctga     2280

agccgagcca gtggaagagg agcactattg cgacatgctc tgctgcaagt tcaaacaccg     2340

cccctggaag aagtaccagt ttccccagag cattgacccg ctgaccaacc tgatgtatgt     2400

cctatggctg ttcttcgtgg tgatggcctg gaattggaac tgttggctga ttcccgtgcg     2460

ctgggccttc ccctaccaga ccccggacaa catccaccac tggctgctga tggattacct     2520

atgcgacctc atctacttcc tggacatcac cgtgttccag acacgcctgc agtttgtcag     2580

aggcggggac atcattacgg acaaaaagga catgcgaaat aactacctga agtctcgccg     2640

cttcaagatg gacctgctca gcctcctgcc cttggatttt ctctatttga aagtcggtgt     2700

gaaccccctc ctccgcctgc cccgctgttt aaagtacatg gccttcttcg agtttaacag     2760

ccgcctggaa tccatcctca gcaaagccta cgtgtacagg gtcatcagga ccacagccta     2820

ccttctctac agcctgcatt tgaattcctg tctttattac tgggcatcgg cctatcaggg     2880

cctcggctcc actcactggg tttacgatgg cgtgggaaac agttatattc gctgttacta     2940

ctttgctgtg aagaccctca tcaccatcgg ggggctgcct gaccccaaga cactctttga     3000

aattgtcttc cagctgctga attatttcac gggcgtcttt gctttctctg tgatgatcgg     3060

acagatgaga gatgtggtag gggccgccac cgcgggacag acctactacc gcagctgcat     3120

ggacagcacg gtgaagtaca tgaatttcta caagatcccc aagtccgtgc agaaccgcgt     3180

caagacctgg tacgagtaca cctggcactc gcaaggcatg ctggatgagt cagagctgat     3240

ggtgcagctt ccagacaaga tgcggctgga cctcgccatc gacgtgaact acaacatcgt     3300

tagcaaagtc gcactctttc agggctgtga ccggcagatg atctttgaca tgctgaagag     3360

gcttcgctct gttgtctacc tgcccaacga ctatgtgtgc aagaaggggg agatcggccg     3420

tgagatgtac atcatccagg cagggcaagt gcaggtcttg ggcggccctg atgggaaatc     3480

tgtgctggtg acgctgaaag ctggatctgt gtttggagaa ataagcttgc tggctgttgg     3540

gggcgggaac cggcgcacgg ccaacgtggt ggcgcacggg tttaccaacc tcttcatcct     3600

ggataagaag gacctgaatg agattttggt gcattatcct gagtctcaga agttactccg     3660

gaagaaagcc aggcgcatgc tgagaagcaa caataagccc aaggaggaga agagcgtgct     3720

gatccttcca ccccgggcgg gcaccccaaa gctcttcaac gctgccctcg ctatgacagg     3780

aaagatgggt ggcaaggggg caaaaggcgg caaacttgct cacctccggg cccggctcaa     3840

agaactggcc gcgctggagg cggctgcaaa gcagcaagag ttggtggaac aggccaagag     3900

ctcgcaagac gtcaagggag aggaaggctc cgccgcccca gaccagcaca cgcacccaaa     3960

ggaggccgcc accgacccac ccgcgccccg gacgcccccc gagcccccgg ggtctccacc     4020

gagctctcca ccgcctgcct cccttgggag gccggaggga gaggaggagg ggccggccga     4080

gcccgaagag cactcggtga ggatctgcat gagcccgggc ccggagccgg gagagcagat     4140

cctgtcggtg aagatgccgg aggaaaggga ggagaaggcg gagtaaggtg gggtgaggcg     4200

gatccatggc cgcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa     4260

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     4320

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     4380

agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtctcgagt     4440

taagggcgaa ttcccgataa ggatcttcct agagcatggc tacgatctga ggaaccccta     4500

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     4560

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga     4620

gagggagtgg ccaa                                                       4634


<210>  45
<211>  533
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(533)
<223>  human RPE65 protein

<400>  45

Met Ser Ile Gln Val Glu His Pro Ala Gly Gly Tyr Lys Lys Leu Phe 
1               5                   10                  15      


Glu Thr Val Glu Glu Leu Ser Ser Pro Leu Thr Ala His Val Thr Gly 
            20                  25                  30          


Arg Ile Pro Leu Trp Leu Thr Gly Ser Leu Leu Arg Cys Gly Pro Gly 
        35                  40                  45              


Leu Phe Glu Val Gly Ser Glu Pro Phe Tyr His Leu Phe Asp Gly Gln 
    50                  55                  60                  


Ala Leu Leu His Lys Phe Asp Phe Lys Glu Gly His Val Thr Tyr His 
65                  70                  75                  80  


Arg Arg Phe Ile Arg Thr Asp Ala Tyr Val Arg Ala Met Thr Glu Lys 
                85                  90                  95      


Arg Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe Pro Asp Pro Cys 
            100                 105                 110         


Lys Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg Gly Val Glu Val 
        115                 120                 125             


Thr Asp Asn Ala Leu Val Asn Val Tyr Pro Val Gly Glu Asp Tyr Tyr 
    130                 135                 140                 


Ala Cys Thr Glu Thr Asn Phe Ile Thr Lys Ile Asn Pro Glu Thr Leu 
145                 150                 155                 160 


Glu Thr Ile Lys Gln Val Asp Leu Cys Asn Tyr Val Ser Val Asn Gly 
                165                 170                 175     


Ala Thr Ala His Pro His Ile Glu Asn Asp Gly Thr Val Tyr Asn Ile 
            180                 185                 190         


Gly Asn Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr Asn Ile Val Lys 
        195                 200                 205             


Ile Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile Ser Lys Ser Glu 
    210                 215                 220                 


Ile Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys Pro Ser Tyr Val 
225                 230                 235                 240 


His Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe Val Glu Thr Pro 
                245                 250                 255     


Val Lys Ile Asn Leu Phe Lys Phe Leu Ser Ser Trp Ser Leu Trp Gly 
            260                 265                 270         


Ala Asn Tyr Met Asp Cys Phe Glu Ser Asn Glu Thr Met Gly Val Trp 
        275                 280                 285             


Leu His Ile Ala Asp Lys Lys Arg Lys Lys Tyr Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Arg Thr Ser Pro Phe Asn Leu Phe His His Ile Asn Thr Tyr Glu Asp 
305                 310                 315                 320 


Asn Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys Gly Phe Glu Phe 
                325                 330                 335     


Val Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu Asn Trp Glu Glu 
            340                 345                 350         


Val Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu Val Arg Arg Tyr 
        355                 360                 365             


Val Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly Lys Asn Leu Val 
    370                 375                 380                 


Thr Leu Pro Asn Thr Thr Ala Thr Ala Ile Leu Cys Ser Asp Glu Thr 
385                 390                 395                 400 


Ile Trp Leu Glu Pro Glu Val Leu Phe Ser Gly Pro Arg Gln Ala Phe 
                405                 410                 415     


Glu Phe Pro Gln Ile Asn Tyr Gln Lys Tyr Cys Gly Lys Pro Tyr Thr 
            420                 425                 430         


Tyr Ala Tyr Gly Leu Gly Leu Asn His Phe Val Pro Asp Arg Leu Cys 
        435                 440                 445             


Lys Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp Gln Glu Pro Asp 
    450                 455                 460                 


Ser Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro Asp Ala Leu Glu 
465                 470                 475                 480 


Glu Asp Asp Gly Val Val Leu Ser Val Val Val Ser Pro Gly Ala Gly 
                485                 490                 495     


Gln Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala Lys Asp Leu Ser Glu 
            500                 505                 510         


Val Ala Arg Ala Glu Val Glu Ile Asn Ile Pro Val Thr Phe His Gly 
        515                 520                 525             


Leu Phe Lys Lys Ser 
    530             


