                         SEQUENCE LISTING

<110>  Synthetic Biologics, Inc.
 
<120>  Beta-Lactamase Formulations

<130>  SYN-023PC

<150>  US 62/474,146
<151>  2017-03-21

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Thr Glu Met Lys Asp Asp Phe Ala Lys Leu Glu Glu Gln Phe Asp Ala 
1               5                   10                  15      


Lys Leu Gly Ile Phe Ala Leu Asp Thr Gly Thr Asn Arg Thr Val Ala 
            20                  25                  30          


Tyr Arg Pro Asp Glu Arg Phe Ala Phe Ala Ser Thr Ile Lys Ala Leu 
        35                  40                  45              


Thr Val Gly Val Leu Leu Gln Gln Lys Ser Ile Glu Asp Leu Asn Gln 
    50                  55                  60                  


Arg Ile Thr Tyr Thr Arg Asp Asp Leu Val Asn Tyr Asn Pro Ile Thr 
65                  70                  75                  80  


Glu Lys His Val Asp Thr Gly Met Thr Leu Lys Glu Leu Ala Asp Ala 
                85                  90                  95      


Ser Leu Arg Tyr Ser Asp Asn Ala Ala Gln Asn Leu Ile Leu Lys Gln 
            100                 105                 110         


Ile Gly Gly Pro Glu Ser Leu Lys Lys Glu Leu Arg Lys Ile Gly Asp 
        115                 120                 125             


Glu Val Thr Asn Pro Glu Arg Phe Glu Pro Glu Leu Asn Glu Val Asn 
    130                 135                 140                 


Pro Gly Glu Thr Gln Asp Thr Ser Thr Ala Arg Ala Leu Val Thr Ser 
145                 150                 155                 160 


Leu Arg Ala Phe Ala Leu Glu Asp Lys Leu Pro Ser Glu Lys Arg Glu 
                165                 170                 175     


Leu Leu Ile Asp Trp Met Lys Arg Asn Thr Thr Gly Asp Ala Leu Ile 
            180                 185                 190         


Arg Ala Gly Val Pro Asp Gly Trp Glu Val Ala Asp Lys Thr Gly Ala 
        195                 200                 205             


Ala Ser Tyr Gly Thr Arg Asn Asp Ile Ala Ile Ile Trp Pro Pro Lys 
    210                 215                 220                 


Gly Asp Pro Val Val Leu Ala Val Leu Ser Ser Arg Asp Lys Lys Asp 
225                 230                 235                 240 


Ala Lys Tyr Asp Asn Lys Leu Ile Ala Glu Ala Thr Lys Val Val Met 
                245                 250                 255     


Lys Ala Leu Asn Met Asn Gly Lys 
            260                 


<210>  2
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
atgactgaga tgaaagatga ttttgcgaag ctggaagaac agtttgacgc aaaattgggc       60

attttcgcgt tggacacggg tacgaatcgt acggttgcct accgtccgga cgagcgcttc      120

gccttcgcga gcacgatcaa agccctgacc gtcggcgtgc tgctccagca aaagagcatc      180

gaggacctga accagcgcat tacctacacc cgtgatgatc tggtgaacta taatccgatc      240

accgagaaac acgttgatac cggtatgacc ctgaaagaac tggcagatgc aagcctgcgc      300

tacagcgata acgcggctca gaatctgatt ctgaagcaaa tcggtggtcc ggagagcttg      360

aagaaagaac tgcgtaaaat cggcgatgaa gtcactaatc cggagcgttt tgagccggag      420

ctgaacgaag tgaatccggg tgaaacgcaa gacacgagca ccgcgcgtgc gcttgtcacc      480

tccctgcgcg ctttcgcact ggaagataag ctgccgtcgg agaaacgcga gctgctgatc      540

gactggatga agcgcaatac gaccggcgac gcgctgattc gtgcgggcgt tccggacggt      600

tgggaagtgg ctgacaagac cggtgcggcg agctacggca cccgtaacga tatcgcgatc      660

atttggccac ctaaaggtga cccggtcgtg ctggccgtac tgagcagccg tgacaagaaa      720

gacgcaaagt atgataacaa gctgattgca gaggcgacca aagttgttat gaaggcactg      780

aacatgaatg gtaag                                                       795


<210>  3
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Glu Met Lys Asp Asp Phe Ala Lys Leu Glu Glu Gln Phe Asp Ala Lys 
1               5                   10                  15      


Leu Gly Ile Phe Ala Leu Asp Thr Gly Thr Asn Arg Thr Val Ala Tyr 
            20                  25                  30          


Arg Pro Asp Glu Arg Phe Ala Phe Ala Ser Thr Ile Lys Ala Leu Thr 
        35                  40                  45              


Val Gly Val Leu Leu Gln Gln Lys Ser Ile Glu Asp Leu Asn Gln Arg 
    50                  55                  60                  


Ile Thr Thr Arg Asp Asp Leu Val Asn Tyr Asn Pro Ile Thr Glu Lys 
65                  70                  75                  80  


His Val Asp Thr Gly Met Thr Leu Lys Glu Leu Ala Asp Ala Ser Leu 
                85                  90                  95      


Arg Tyr Ser Asp Asn Ala Ala Gln Asn Leu Ile Leu Lys Gln Ile Gly 
            100                 105                 110         


Gly Pro Glu Ser Leu Lys Lys Glu Leu Arg Lys Ile Gly Asp Glu Val 
        115                 120                 125             


Thr Asn Pro Glu Arg Phe Glu Pro Glu Leu Asn Glu Val Asn Pro Gly 
    130                 135                 140                 


Glu Thr Gln Asp Thr Ser Thr Ala Arg Ala Leu Val Thr Ser Leu Arg 
145                 150                 155                 160 


Ala Phe Ala Leu Glu Asp Lys Leu Pro Ser Glu Lys Arg Glu Leu Leu 
                165                 170                 175     


Ile Asp Trp Met Lys Arg Asn Thr Thr Gly Asp Ala Leu Ile Arg Ala 
            180                 185                 190         


Gly Val Pro Asp Gly Trp Glu Val Gly Asp Lys Thr Gly Ser Gly Asp 
        195                 200                 205             


Tyr Gly Thr Arg Asn Asp Ile Ala Ile Ile Trp Pro Pro Lys Gly Asp 
    210                 215                 220                 


Pro Val Val Leu Ala Val Leu Ser Ser Arg Asp Lys Lys Asp Ala Lys 
225                 230                 235                 240 


Tyr Asp Asn Lys Leu Ile Ala Glu Ala Thr Lys Val Val Met Lys Ala 
                245                 250                 255     


Leu Asn Met Asn Gly Lys 
            260         


<210>  4
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Ile Gln Lys Arg Lys Arg Thr Val Ser Phe Arg Leu Val Leu Met 
1               5                   10                  15      


Cys Thr Leu Leu Phe Val Ser Leu Pro Ile Thr Lys Thr Ser Ala Gln 
            20                  25                  30          


Ala Ser Lys Thr Glu Met Lys Asp Asp Phe Ala Lys Leu Glu Glu Gln 
        35                  40                  45              


Phe Asp Ala Lys Leu Gly Ile Phe Ala Leu Asp Thr Gly Thr Asn Arg 
    50                  55                  60                  


Thr Val Ala Tyr Arg Pro Asp Glu Arg Phe Ala Phe Ala Ser Thr Ile 
65                  70                  75                  80  


Lys Ala Leu Thr Val Gly Val Leu Leu Gln Gln Lys Ser Ile Glu Asp 
                85                  90                  95      


Leu Asn Gln Arg Ile Thr Tyr Thr Arg Asp Asp Leu Val Asn Tyr Asn 
            100                 105                 110         


Pro Ile Thr Glu Lys His Val Asp Thr Gly Met Thr Leu Lys Glu Leu 
        115                 120                 125             


Ala Asp Ala Ser Leu Arg Tyr Ser Asp Asn Ala Ala Gln Asn Leu Ile 
    130                 135                 140                 


Leu Lys Gln Ile Gly Gly Pro Glu Ser Leu Lys Lys Glu Leu Arg Lys 
145                 150                 155                 160 


Ile Gly Asp Glu Val Thr Asn Pro Glu Arg Phe Glu Pro Glu Leu Asn 
                165                 170                 175     


Glu Val Asn Pro Gly Glu Thr Gln Asp Thr Ser Thr Ala Arg Ala Leu 
            180                 185                 190         


Val Thr Ser Leu Arg Ala Phe Ala Leu Glu Asp Lys Leu Pro Ser Glu 
        195                 200                 205             


Lys Arg Glu Leu Leu Ile Asp Trp Met Lys Arg Asn Thr Thr Gly Asp 
    210                 215                 220                 


Ala Leu Ile Arg Ala Gly Val Pro Asp Gly Trp Glu Val Gly Asp Lys 
225                 230                 235                 240 


Thr Gly Ser Gly Asp Tyr Gly Thr Arg Asn Asp Ile Ala Ile Ile Trp 
                245                 250                 255     


Pro Pro Lys Gly Asp Pro Val Val Leu Ala Val Leu Ser Ser Arg Asp 
            260                 265                 270         


Lys Lys Asp Ala Lys Tyr Asp Asn Lys Leu Ile Ala Glu Ala Thr Lys 
        275                 280                 285             


Val Val Met Lys Ala Leu Asn Met Asn Gly Lys 
    290                 295                 


<210>  5
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
atgattcaaa aacgaaagcg gacagtttcg ttcagacttg tgcttatgtg cacgctgtta       60

tttgtcagtt tgccgattac aaaaacatca gcgcaagctt ccaagacgga gatgaaagat      120

gattttgcaa aacttgagga acaatttgat gcaaaactcg ggatctttgc attggataca      180

ggtacaaacc ggacggtagc gtatcggccg gatgagcgtt ttgcttttgc ttcgacgatt      240

aaggctttaa ctgtaggcgt gcttttgcaa cagaaatcaa tagaagatct gaaccagaga      300

ataacatata cacgtgatga tcttgtaaac tacaacccga ttacggaaaa gcacgttgat      360

acgggaatga cgctcaaaga gcttgcggat gcttcgcttc gatatagtga caatgcggca      420

cagaatctca ttcttaaaca aattggcgga cctgaaagtt tgaaaaagga actgaggaag      480

attggtgatg aggttacaaa tcccgaacga ttcgaaccag agttaaatga agtgaatccg      540

ggtgaaactc aggataccag tacagcaaga gcacttgtca caagccttcg agcctttgct      600

cttgaagata aacttccaag tgaaaaacgc gagcttttaa tcgattggat gaaacgaaat      660

accactggag acgccttaat ccgtgccggt gtgccggacg gttgggaagt gggtgataaa      720

actggaagcg gagattatgg aacccggaat gacattgcca tcatttggcc gccaaaagga      780

gatcctgtcg ttcttgcagt attatccagc agggataaaa aggacgccaa gtatgataat      840

aaacttattg cagaggcaac aaaggtggta atgaaagcct taaacatgaa cggcaaataa      900


<210>  6
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Glu Thr Gly Thr Ile Ser Ile Ser Gln Leu Asn Lys Asn Val Trp Val 
1               5                   10                  15      


His Thr Glu Leu Gly Tyr Phe Asn Gly Glu Ala Val Pro Ser Asn Gly 
            20                  25                  30          


Leu Val Leu Asn Thr Ser Lys Gly Leu Val Leu Val Asp Ser Ser Trp 
        35                  40                  45              


Asp Asn Lys Leu Thr Lys Glu Leu Ile Glu Met Val Glu Lys Lys Phe 
    50                  55                  60                  


Gln Lys Arg Val Thr Asp Val Ile Ile Thr His Ala His Ala Asp Arg 
65                  70                  75                  80  


Ile Gly Gly Ile Thr Ala Leu Lys Glu Arg Gly Ile Lys Ala His Ser 
                85                  90                  95      


Thr Ala Leu Thr Ala Glu Leu Ala Lys Asn Ser Gly Tyr Glu Glu Pro 
            100                 105                 110         


Leu Gly Asp Leu Gln Thr Ile Thr Ser Leu Lys Phe Gly Asn Thr Lys 
        115                 120                 125             


Val Glu Thr Phe Tyr Pro Gly Lys Gly His Thr Glu Asp Asn Ile Val 
    130                 135                 140                 


Val Trp Leu Pro Gln Tyr Gln Ile Leu Ala Gly Gly Cys Leu Val Lys 
145                 150                 155                 160 


Ser Ala Glu Ala Lys Asp Leu Gly Asn Val Ala Asp Ala Tyr Val Asn 
                165                 170                 175     


Glu Trp Ser Thr Ser Ile Glu Asn Val Leu Lys Arg Tyr Gly Asn Ile 
            180                 185                 190         


Asn Ser Val Val Pro Gly His Gly Glu Val Gly Asp Lys Gly Leu Leu 
        195                 200                 205             


Leu His Thr Leu Asp Leu Leu Lys 
    210                 215     


