                         SEQUENCE LISTING

<110>  Novartis AG
       Beth Israel Deaconess Medical Center, Inc
 
<120>  Methods for Preventing and Treating Heart Disease

<130>  057695

<141>  2018-03-20

<150>  US 62/476,054

<151>  2017-03-24



<160>  194   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  1

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  2

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  3

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  4

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  5

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  6

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  7

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  8

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  9

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  10

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  11

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  12

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  13

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  14

Gly Tyr Thr Phe Thr Ser Ser Tyr Ile Asn 
1               5                   10  


<210>  15
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  15

Thr Ile Asn Pro Val Ser Gly Asn Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  16

Thr Ile Asn Pro Val Ser Gly Asn Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  17

Thr Ile Asn Pro Val Ser Gly Asn Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  18

Thr Ile Asn Pro Val Ser Gly Asn Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  19

Met Ile Asn Ala Pro Ile Gly Thr Thr Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  20

Gln Ile Asn Ala Ala Ser Gly Met Thr Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  21

Met Ile Asn Ala Pro Ile Gly Thr Thr Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  22

Thr Ile Asn Pro Val Ser Gly Asn Thr Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  23

Thr Ile Asn Pro Val Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  24

Gln Ile Asn Ala Ala Ser Gly Met Thr Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  25

Asn Ile Asn Ala Ala Ala Gly Ile Thr Leu Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  26

Thr Ile Asn Pro Pro Thr Gly Gly Thr Tyr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  27

Gly Ile Asn Pro Pro Ala Gly Thr Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  28

Asn Ile Asn Pro Ala Thr Gly His Ala Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  29

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  30

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  31

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  32

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  33
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  33

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  34

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  35

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  36

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  37

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  38

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  39

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  40

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  41

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  42

Gly Gly Trp Phe Asp Tyr 
1               5       


<210>  43
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  43

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  44

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  45

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  46

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  47

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  48

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  49

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  50
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  50

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  51
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  51

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  52

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  53
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  53

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  54

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  55

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  56
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  56

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Tyr Val Asn 
1               5                   10                  


<210>  57
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  57

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  58
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  58

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  59

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  60

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  61
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  61

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  62

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  63

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  64

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  65

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  66
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  66

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  67
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  67

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  68
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  68

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  69
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  69

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  70
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  70

Leu Met Ile Tyr Gly Val Ser Lys Arg Pro Ser 
1               5                   10      


<210>  71
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  71

Gln Ala Trp Thr Ser Lys Met Ala Gly 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  72

Ser Ser Tyr Thr Arg Met Gly His Pro 
1               5                   


<210>  73
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  73

Ala Thr Tyr Gly Lys Gly Val Thr Pro Pro 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  74

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  75
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  75

Gln Ala Trp Thr Ser Lys Met Ala Gly 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  76

Gln Ala Trp Thr Ser Lys Met Ala Gly 
1               5                   


<210>  77
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  77

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  78

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  79

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  80

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  81

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  82

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  83

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR

<400>  84

Gly Thr Phe Ala Gly Gly Ser Tyr Tyr Gly 
1               5                   10  


<210>  85
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  85

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Thr Ser Lys 
                85                  90                  95      


Met Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  86
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  86

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Arg Met 
                85                  90                  95      


Gly His Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  87
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  87

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Gly Lys Gly 
                85                  90                  95      


Val Thr Pro Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  88
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  88

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  89
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  89

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Thr Ser Lys 
                85                  90                  95      


Met Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  90
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  90

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Thr Ser Lys 
                85                  90                  95      


Met Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  91
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  91

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  92
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  92

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  93
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  93

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  94
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  94

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  95
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  95

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  96
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  96

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  97
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  97

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  98
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  VL

<400>  98

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  99
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  99

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Asn Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  100
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Asn Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  101
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  101

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Asn Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  102
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Asn Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  103
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Ala Pro Ile Gly Thr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  104
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Ala Ala Ser Gly Met Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  105
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  105

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asn Ala Pro Ile Gly Thr Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  106
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  106

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Asn Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  107
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  108
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Ala Ala Ser Gly Met Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  109
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asn Ala Ala Ala Gly Ile Thr Leu Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  110
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  110

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Pro Thr Gly Gly Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  111
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Pro Ala Gly Thr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  112
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  VH

<400>  112

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asn Pro Ala Thr Gly His Ala Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  113
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  113
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc caggcttgga cttctaagat ggctggtgtg      300

tttggcggcg gcacgaagtt aaccgttctt ggccag                                336


<210>  114
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  114
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc tcttcttata ctcgtatggg tcatcctgtg      300

tttggcggcg gcacgaagtt aaccgttctt ggccag                                336


<210>  115
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  115
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc gctacttatg gtaagggtgt tactcctcct      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  116
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  116
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  117
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  117
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc caggcttgga cttctaagat ggctggtgtg      300

tttggcggcg gcacgaagtt aaccgttctt ggccag                                336


<210>  118
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  118
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc caggcttgga cttctaagat ggctggtgtg      300

tttggcggcg gcacgaagtt aaccgttctt ggccag                                336


<210>  119
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  119
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  120
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  120
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  121
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  121
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  122
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  122
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  123
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  123
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  124
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  124
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtactg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  125
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  125
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  126
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  VL

<400>  126
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                             339


<210>  127
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  127
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcact atcaatccgg tttctggcaa tacgtcttac      180

gcgcagaagt ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  128
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  128
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcact atcaatccgg tttctggcaa tacgtcttac      180

gcgcagaagt ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  129
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  129
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcact atcaatccgg tttctggcaa tacgtcttac      180

gcgcagaagt ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  130
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  130
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcact atcaatccgg tttctggcaa tacgtcttac      180

gcgcagaagt ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  131
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  131
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcatg attaatgctc ctattggtac tactcgttat      180

gctcagaagt ttcagggtcg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  132
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  132
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggccag attaatgctg cttctggtat gactcgttat      180

gctcagaagt ttcagggtcg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  133
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  133
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcatg attaatgctc ctattggtac tactcgttat      180

gctcagaagt ttcagggtcg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  134
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  134
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcact atcaatccgg tttctggcaa tacgcgttac      180

gcgcagaagt ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  135
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  135
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcact atcaatccgg tttctggctc tacgtcttac      180

gcgcagaagt ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  136
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  136
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggccag attaatgctg cttctggtat gactcgttat      180

gctcagaagt ttcagggtcg ggtcaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  137
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  137
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcaat attaatgctg ctgctggtat tactctttat      180

gctcagaagt ttcagggtcg ggtcaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  138
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  138
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcact attaatcctc ctactggagg tacttattat      180

gctcagaagt ttcagggtcg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  139
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  139
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcggt attaatcctc ctgctggtac tacttcttat      180

gctcagaagt ttcagggtcg ggtcaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  140
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  VH

<400>  140
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcaat attaatcctg ctactggtca tgctgattat      180

gctcagaagt ttcagggtcg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctca                      345


<210>  141
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  141

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  142
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  142

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  143
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  143

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  144
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  144

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  145
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  145

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  146
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  146

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  147
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  147

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Ala Ala Ser Gly Met Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  148
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  148

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asn Ala Ala Ala Gly Ile Thr Leu Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  149
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  149

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Pro Ala Gly Thr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  150
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  150

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asn Pro Ala Thr Gly His Ala Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  151
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  151

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  152
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  152

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  153
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  153

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  154
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  154

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  155
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  light chain

<400>  155

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  156
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  156

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  157
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  157

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Ala Ala Ser Gly Met Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  158
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  158

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asn Ala Ala Ala Gly Ile Thr Leu Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  159
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Pro Ala Gly Thr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  160
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain

<400>  160

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Asn Pro Ala Thr Gly His Ala Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  161
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  161
cagagcgccc tgacccagcc cgccagcgtg tccggcagcc caggccagtc tatcacaatc       60

agctgcaccg gcacctccag cgacgtgggc agctacaact acgtgaactg gtatcagcag      120

caccccggca aggcccccaa gctgatgatc tacggcgtga gcaagaggcc cagcggcgtg      180

tccaacaggt tcagcggcag caagagcggc aacaccgcca gcctgacaat cagtgggctg      240

caggctgagg acgaggccga ctactactgc ggcacctttg ccggcggatc atactacggc      300

gtgttcggcg gagggaccaa gctgaccgtg ctgggccagc ctaaggctgc ccccagcgtg      360

accctgttcc cccccagcag cgaggagctg caggccaaca aggccaccct ggtgtgcctg      420

atcagcgact tctacccagg cgccgtgacc gtggcctgga aggccgacag cagccccgtg      480

aaggccggcg tggagaccac cacccccagc aagcagagca acaacaagta cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagagccaca ggtcctacag ctgccaggtg      600

acccacgagg gcagcaccgt ggaaaagacc gtggccccaa ccgagtgcag c               651


<210>  162
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  162
cagagcgccc tgacccagcc cgccagcgtg tccggcagcc caggccagtc tatcacaatc       60

agctgcaccg gcacctccag cgacgtgggc agctacaact acgtgaactg gtatcagcag      120

caccccggca aggcccccaa gctgatgatc tacggcgtga gcaagaggcc cagcggcgtg      180

tccaacaggt tcagcggcag caagagcggc aacaccgcca gcctgacaat cagtgggctg      240

caggctgagg acgaggccga ctactactgc ggcacctttg ccggcggatc atactacggc      300

gtgttcggcg gagggaccaa gctgaccgtg ctgggccagc ctaaggctgc ccccagcgtg      360

accctgttcc cccccagcag cgaggagctg caggccaaca aggccaccct ggtgtgcctg      420

atcagcgact tctacccagg cgccgtgacc gtggcctgga aggccgacag cagccccgtg      480

aaggccggcg tggagaccac cacccccagc aagcagagca acaacaagta cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagagccaca ggtcctacag ctgccaggtg      600

acccacgagg gcagcaccgt ggaaaagacc gtggccccaa ccgagtgcag c               651


<210>  163
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  163
cagagcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  164
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  164
cagagcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  165
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  165
cagagcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  166
<211>  1335
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  166
caggtgcagc tggtgcagag cggagctgag gtgaagaagc caggcgccag cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agcagctaca tcaactgggt ccgccaggct      120

cctgggcagg gactggagtg gatgggcacc atcaaccccg tgtccggcag caccagctac      180

gcccagaagt tccagggcag agtcaccatg accagggaca ccagcatcag caccgcctac      240

atggagctgt ccaggctgag aagcgacgac accgccgtgt actactgcgc caggggcggc      300

tggttcgact actggggcca gggcaccctg gtgaccgtgt cctcagctag caccaagggc      360

cccagcgtgt tccccctggc ccccagcagc aagagcacct ccggcggcac agccgccctg      420

ggctgcctgg tgaaggacta cttccccgag cccgtgaccg tgtcctggaa cagcggagcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

tccagcgtgg tgacagtgcc cagcagcagc ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaggtggac aagagagtgg agcccaagag ctgcgacaag      660

acccacacct gccccccctg cccagccccc gaagctgcag gcggcccttc cgtgttcctg      720

ttccccccca agcccaagga caccctgatg atcagcagga cccccgaggt gacctgcgtg      780

gtggtggacg tgagccacga ggacccagag gtgaagttca actggtacgt ggacggcgtg      840

gaggtgcaca acgccaagac caagcccaga gaggagcagt acaacagcac ctacagggtg      900

gtgtccgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaagaata caagtgcaag      960

gtctccaaca aggccctgcc tgcccccatc gaaaagacca tcagcaaggc caagggccag     1020

ccacgggagc cccaggtgta caccctgccc ccttctcggg aggagatgac caagaaccag     1080

gtgtccctga cctgtctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaacggcc agcccgagaa caactacaag accacccccc cagtgctgga cagcgacggc     1200

agcttcttcc tgtacagcaa gctgaccgtg gacaagagca ggtggcagca gggcaacgtg     1260

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc     1320

ctgtcacccg gcaag                                                      1335


<210>  167
<211>  1335
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  167
caggtgcagc tggtgcagag cggagctgag gtgaagaagc caggcgccag cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agcagctaca tcaactgggt gcgccaggct      120

ccagggcagg gactggagtg gatgggccag atcaacgccg ccagcggcat gaccagatac      180

gcccagaagt tccagggcag agtcacaatg accagggaca cctctatcag caccgcctac      240

atggagctgt ccaggctgag aagcgacgac accgccgtgt actactgcgc caggggcggc      300

tggttcgact actggggcca gggcaccctg gtgaccgtgt cctcagctag caccaagggc      360

cccagcgtgt tccccctggc ccccagcagc aagagcacct ccggcggcac agccgccctg      420

ggctgcctgg tgaaggacta cttccccgag cccgtgaccg tgtcctggaa cagcggagcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

tccagcgtgg tgacagtgcc cagcagcagc ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaggtggac aagagagtgg agcccaagag ctgcgacaag      660

acccacacct gccccccctg cccagccccc gaagctgcag gcggcccttc cgtgttcctg      720

ttccccccca agcccaagga caccctgatg atcagcagga cccccgaggt gacctgcgtg      780

gtggtggacg tgagccacga ggacccagag gtgaagttca actggtacgt ggacggcgtg      840

gaggtgcaca acgccaagac caagcccaga gaggagcagt acaacagcac ctacagggtg      900

gtgtccgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaagaata caagtgcaag      960

gtctccaaca aggccctgcc tgcccccatc gaaaagacca tcagcaaggc caagggccag     1020

ccacgggagc cccaggtgta caccctgccc ccttctcggg aggagatgac caagaaccag     1080

gtgtccctga cctgtctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaacggcc agcccgagaa caactacaag accacccccc cagtgctgga cagcgacggc     1200

agcttcttcc tgtacagcaa gctgaccgtg gacaagagca ggtggcagca gggcaacgtg     1260

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc     1320

ctgtcacccg gcaag                                                      1335


<210>  168
<211>  1335
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  168
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcaat attaatgctg ctgctggtat tactctttat      180

gctcagaagt ttcagggtcg ggtcaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gccgcctgcg tagcgatgat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctcagcctc caccaagggt      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagcagcgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgggtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  169
<211>  1335
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  169
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcggt attaatcctc ctgctggtac tacttcttat      180

gctcagaagt ttcagggtcg ggtcaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gccgcctgcg tagcgatgat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctcagcctc caccaagggt      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagcagcgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgggtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  170
<211>  1335
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  170
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcaat attaatcctg ctactggtca tgctgattat      180

gctcagaagt ttcagggtcg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gccgcctgcg tagcgatgat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctcagcctc caccaagggt      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagcagcgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgggtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  171
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  171
cagagcgccc tgacccagcc cgccagcgtg tccggcagcc caggccagtc tatcacaatc       60

agctgcaccg gcacctccag cgacgtgggc agctacaact acgtgaactg gtatcagcag      120

caccccggca aggcccccaa gctgatgatc tacggcgtga gcaagaggcc cagcggcgtg      180

tccaacaggt tcagcggcag caagagcggc aacaccgcca gcctgacaat cagtgggctg      240

caggctgagg acgaggccga ctactactgc ggcacctttg ccggcggatc atactacggc      300

gtgttcggcg gagggaccaa gctgaccgtg ctgggccagc ctaaggctgc ccccagcgtg      360

accctgttcc cccccagcag cgaggagctg caggccaaca aggccaccct ggtgtgcctg      420

atcagcgact tctacccagg cgccgtgacc gtggcctgga aggccgacag cagccccgtg      480

aaggccggcg tggagaccac cacccccagc aagcagagca acaacaagta cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagagccaca ggtcctacag ctgccaggtg      600

acccacgagg gcagcaccgt ggaaaagacc gtggccccaa ccgagtgcag c               651


<210>  172
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  172
cagagcgccc tgacccagcc cgccagcgtg tccggcagcc caggccagtc tatcacaatc       60

agctgcaccg gcacctccag cgacgtgggc agctacaact acgtgaactg gtatcagcag      120

caccccggca aggcccccaa gctgatgatc tacggcgtga gcaagaggcc cagcggcgtg      180

tccaacaggt tcagcggcag caagagcggc aacaccgcca gcctgacaat cagtgggctg      240

caggctgagg acgaggccga ctactactgc ggcacctttg ccggcggatc atactacggc      300

gtgttcggcg gagggaccaa gctgaccgtg ctgggccagc ctaaggctgc ccccagcgtg      360

accctgttcc cccccagcag cgaggagctg caggccaaca aggccaccct ggtgtgcctg      420

atcagcgact tctacccagg cgccgtgacc gtggcctgga aggccgacag cagccccgtg      480

aaggccggcg tggagaccac cacccccagc aagcagagca acaacaagta cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagagccaca ggtcctacag ctgccaggtg      600

acccacgagg gcagcaccgt ggaaaagacc gtggccccaa ccgagtgcag c               651


<210>  173
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  173
cagagcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  174
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  174
cagagcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  175
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  light chain

<400>  175
cagagcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc       60

tcgtgtacgg gtactagcag cgatgttggt tcttataatt atgtgaattg gtaccagcag      120

catcccggga aggcgccgaa acttatgatt tatggtgttt ctaagcgtcc ctcaggcgtg      180

agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caagcggaag acgaagcgga ttattattgc ggtacttttg ctggtggttc ttattatggt      300

gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  176
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  176
caggtgcagc tggtgcagag cggagctgag gtgaagaagc caggcgccag cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agcagctaca tcaactgggt ccgccaggct      120

cctgggcagg gactggagtg gatgggcacc atcaaccccg tgtccggcag caccagctac      180

gcccagaagt tccagggcag agtcaccatg accagggaca ccagcatcag caccgcctac      240

atggagctgt ccaggctgag aagcgacgac accgccgtgt actactgcgc caggggcggc      300

tggttcgact actggggcca gggcaccctg gtgaccgtgt cctcagctag caccaagggc      360

cccagcgtgt tccccctggc cccctgcagc agaagcacca gcgagagcac agccgccctg      420

ggctgcctgg tgaaggacta cttccccgag ccagtgaccg tgtcctggaa cagcggagcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

tccagcgtgg tgaccgtgcc cagcagcaac ttcggcaccc agacctacac ctgcaacgtg      600

gaccacaagc ccagcaacac caaggtggac aagaccgtgg agaggaagtg ctgcgtggag      660

tgccccccct gcccagcccc cccagtggcc ggaccctccg tgttcctgtt cccccccaag      720

cccaaggaca ccctgatgat cagcaggacc cccgaggtga cctgcgtggt ggtggacgtg      780

agccacgagg acccagaggt gcagttcaac tggtacgtgg acggcgtgga ggtgcacaac      840

gccaagacca agcccagaga ggaacagttt aacagcacct tcagggtggt gtccgtgctg      900

accgtggtgc accaggactg gctgaacggc aaagagtaca agtgcaaggt ctccaacaag      960

ggcctgccag cccccatcga gaaaaccatc agcaagacca agggccagcc acgggagccc     1020

caggtgtaca ccctgccccc cagccgggag gaaatgacca agaaccaggt gtccctgacc     1080

tgtctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag caacggccag     1140

cccgagaaca actacaagac cacccccccc atgctggaca gcgacggcag cttcttcctg     1200

tacagcaagc tgacagtgga caagagcagg tggcagcagg gcaacgtgtt cagctgcagc     1260

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gtcccccggc     1320

aag                                                                   1323


<210>  177
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  177
caggtgcagc tggtgcagag cggagctgag gtgaagaagc caggcgccag cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcacc agcagctaca tcaactgggt gcgccaggct      120

ccagggcagg gactggagtg gatgggccag atcaacgccg ccagcggcat gaccagatac      180

gcccagaagt tccagggcag agtcacaatg accagggaca cctctatcag caccgcctac      240

atggagctgt ccaggctgag aagcgacgac accgccgtgt actactgcgc caggggcggc      300

tggttcgact actggggcca gggcaccctg gtgaccgtgt cctcagctag caccaagggc      360

cccagcgtgt tccccctggc cccctgcagc agaagcacca gcgagagcac agccgccctg      420

ggctgcctgg tgaaggacta cttccccgag ccagtgaccg tgtcctggaa cagcggagcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

tccagcgtgg tgaccgtgcc cagcagcaac ttcggcaccc agacctacac ctgcaacgtg      600

gaccacaagc ccagcaacac caaggtggac aagaccgtgg agaggaagtg ctgcgtggag      660

tgccccccct gcccagcccc cccagtggcc ggaccctccg tgttcctgtt cccccccaag      720

cccaaggaca ccctgatgat cagcaggacc cccgaggtga cctgcgtggt ggtggacgtg      780

agccacgagg acccagaggt gcagttcaac tggtacgtgg acggcgtgga ggtgcacaac      840

gccaagacca agcccagaga ggaacagttt aacagcacct tcagggtggt gtccgtgctg      900

accgtggtgc accaggactg gctgaacggc aaagagtaca agtgcaaggt ctccaacaag      960

ggcctgccag cccccatcga gaaaaccatc agcaagacca agggccagcc acgggagccc     1020

caggtgtaca ccctgccccc cagccgggag gaaatgacca agaaccaggt gtccctgacc     1080

tgtctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag caacggccag     1140

cccgagaaca actacaagac cacccccccc atgctggaca gcgacggcag cttcttcctg     1200

tacagcaagc tgacagtgga caagagcagg tggcagcagg gcaacgtgtt cagctgcagc     1260

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gtcccccggc     1320

aag                                                                   1323


<210>  178
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  178
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcaat attaatgctg ctgctggtat tactctttat      180

gctcagaagt ttcagggtcg ggtcaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gccgcctgcg tagcgatgat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctcagcttc caccaagggc      360

cccagcgtgt tccccctggc cccctgcagc agaagcacca gcgagagcac agccgccctg      420

ggctgcctgg tgaaggacta cttccccgag cccgtgaccg tgagctggaa cagcggagcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

agcagcgtgg tgaccgtgcc cagcagcaac ttcggcaccc agacctacac ctgcaacgtg      600

gaccacaagc ccagcaacac caaggtggac aagaccgtgg agcggaagtg ctgcgtggag      660

tgccccccct gccctgcccc tcctgtggcc ggaccctccg tgttcctgtt cccccccaag      720

cccaaggaca ccctgatgat cagccggacc cccgaggtga cctgcgtggt ggtggacgtg      780

agccacgagg accccgaggt gcagttcaac tggtacgtgg acggcgtgga ggtgcacaac      840

gccaagacca agccccggga ggaacagttc aacagcacct tccgggtggt gtccgtgctg      900

accgtggtgc accaggactg gctgaacggc aaagaataca agtgcaaggt gtccaacaag      960

ggcctgcctg cccccatcga gaaaaccatc agcaagacaa agggccagcc cagggaaccc     1020

caggtgtaca ccctgccccc cagccgggag gaaatgacca agaaccaggt gtccctgacc     1080

tgtctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag caacggccag     1140

cccgagaaca actacaagac cacccccccc atgctggaca gcgacggcag cttcttcctg     1200

tacagcaagc tgacagtgga caagagccgg tggcagcagg gcaacgtgtt cagctgcagc     1260

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gtcccccggc     1320

aaa                                                                   1323


<210>  179
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  179
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcggt attaatcctc ctgctggtac tacttcttat      180

gctcagaagt ttcagggtcg ggtcaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gccgcctgcg tagcgatgat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctcagcttc caccaagggc      360

cccagcgtgt tccccctggc cccctgcagc agaagcacca gcgagagcac agccgccctg      420

ggctgcctgg tgaaggacta cttccccgag cccgtgaccg tgagctggaa cagcggagcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

agcagcgtgg tgaccgtgcc cagcagcaac ttcggcaccc agacctacac ctgcaacgtg      600

gaccacaagc ccagcaacac caaggtggac aagaccgtgg agcggaagtg ctgcgtggag      660

tgccccccct gccctgcccc tcctgtggcc ggaccctccg tgttcctgtt cccccccaag      720

cccaaggaca ccctgatgat cagccggacc cccgaggtga cctgcgtggt ggtggacgtg      780

agccacgagg accccgaggt gcagttcaac tggtacgtgg acggcgtgga ggtgcacaac      840

gccaagacca agccccggga ggaacagttc aacagcacct tccgggtggt gtccgtgctg      900

accgtggtgc accaggactg gctgaacggc aaagaataca agtgcaaggt gtccaacaag      960

ggcctgcctg cccccatcga gaaaaccatc agcaagacaa agggccagcc cagggaaccc     1020

caggtgtaca ccctgccccc cagccgggag gaaatgacca agaaccaggt gtccctgacc     1080

tgtctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag caacggccag     1140

cccgagaaca actacaagac cacccccccc atgctggaca gcgacggcag cttcttcctg     1200

tacagcaagc tgacagtgga caagagccgg tggcagcagg gcaacgtgtt cagctgcagc     1260

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gtcccccggc     1320

aaa                                                                   1323


<210>  180
<211>  1323
<212>  DNA
<213>  Artificial

<220>
<223>  heavy chain

<400>  180
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cctccggata tacctttact tcttcttata ttaattgggt ccgccaagcc      120

cctgggcagg gtctcgagtg gatgggcaat attaatcctg ctactggtca tgctgattat      180

gctcagaagt ttcagggtcg ggtgaccatg acccgtgata ccagcattag caccgcgtat      240

atggaactga gccgcctgcg tagcgatgat acggccgtgt attattgcgc gcgtggtggt      300

tggtttgatt attggggcca aggcaccctg gtgacggtta gctcagcttc caccaagggc      360

cccagcgtgt tccccctggc cccctgcagc agaagcacca gcgagagcac agccgccctg      420

ggctgcctgg tgaaggacta cttccccgag cccgtgaccg tgagctggaa cagcggagcc      480

ctgaccagcg gcgtgcacac cttccccgcc gtgctgcaga gcagcggcct gtacagcctg      540

agcagcgtgg tgaccgtgcc cagcagcaac ttcggcaccc agacctacac ctgcaacgtg      600

gaccacaagc ccagcaacac caaggtggac aagaccgtgg agcggaagtg ctgcgtggag      660

tgccccccct gccctgcccc tcctgtggcc ggaccctccg tgttcctgtt cccccccaag      720

cccaaggaca ccctgatgat cagccggacc cccgaggtga cctgcgtggt ggtggacgtg      780

agccacgagg accccgaggt gcagttcaac tggtacgtgg acggcgtgga ggtgcacaac      840

gccaagacca agccccggga ggaacagttc aacagcacct tccgggtggt gtccgtgctg      900

accgtggtgc accaggactg gctgaacggc aaagaataca agtgcaaggt gtccaacaag      960

ggcctgcctg cccccatcga gaaaaccatc agcaagacaa agggccagcc cagggaaccc     1020

caggtgtaca ccctgccccc cagccgggag gaaatgacca agaaccaggt gtccctgacc     1080

tgtctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag caacggccag     1140

cccgagaaca actacaagac cacccccccc atgctggaca gcgacggcag cttcttcctg     1200

tacagcaagc tgacagtgga caagagccgg tggcagcagg gcaacgtgtt cagctgcagc     1260

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gtcccccggc     1320

aaa                                                                   1323


<210>  181
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Ala Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210>  182
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  182

Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala 
1               5                   10                  15      


Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu 
            20                  25                  30          


Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser 
        35                  40                  45              


Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr 
                85                  90                  95      


His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro 
            100                 105                 110         


Thr Ala Pro Thr 
        115     


<210>  183
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  183

Ile Glu Leu Val Lys Lys Gly Ser Trp Leu Asp Asp Phe Asn Ser 
1               5                   10                  15  


<210>  184
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  184

Val Lys Lys Gly Ser Trp Leu Asp Asp Phe Asn Ser Tyr Asp Arg 
1               5                   10                  15  


<210>  185
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  185

Gly Ser Trp Leu Asp Asp Phe Asn Ser Tyr Asp Arg Gln Glu Ser 
1               5                   10                  15  


<210>  186
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  186

Gly Cys Trp Leu Asp Asp Phe Asn Cys 
1               5                   


<210>  187
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  187

Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp 
1               5                   10                  15  


<210>  188
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  188

Trp Leu Asp Asp Phe Asn 
1               5       


<210>  189
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  189

Glu Gln Asp Lys Arg 
1               5   


<210>  190
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  190

Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
1               5                   10      


<210>  191
<211>  13
<212>  PRT
<213>  Human

<400>  191

Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg Thr 
1               5                   10              


<210>  192
<211>  11
<212>  PRT
<213>  Human

<400>  192

Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn 
1               5                   10      


<210>  193
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<400>  193

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Phe Ala Gly Gly 
                85                  90                  95      


Ser Tyr Tyr Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ser Thr Pro Thr Leu Thr Val Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Lys Glu Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asn Phe 
    130                 135                 140                 


Ser Pro Ser Gly Val Thr Val Ala Trp Lys Ala Asn Gly Thr Pro Ile 
145                 150                 155                 160 


Thr Gln Gly Val Asp Thr Ser Asn Pro Thr Lys Glu Gly Asn Lys Phe 
                165                 170                 175     


Met Ala Ser Ser Phe Leu His Leu Thr Ser Asp Gln Trp Arg Ser His 
            180                 185                 190         


Asn Ser Phe Thr Cys Gln Val Thr His Glu Gly Asp Thr Val Glu Lys 
        195                 200                 205             


Ser Leu Ser Pro Ala Glu Cys Leu 
    210                 215     


<210>  194
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy Chain

<400>  194

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asn Pro Val Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
    210                 215                 220                 


Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
            260                 265                 270         


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
    290                 295                 300                 


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
305                 310                 315                 320 


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
                325                 330                 335     


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
            340                 345                 350         


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
        355                 360                 365             


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
    370                 375                 380                 


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
                405                 410                 415     


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445 


