                               SEQUENCE LISTING

<110> GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE 
      SECRETARY OF THE ARMY
 
<120> A METHOD FOR DEVELOPING AND EMPLOYING RECOMBINANT 
      ADENO-ASSOCIATED VIRUS - PARAOXONASE 1-IF11 PARTICLES FOR 
      PROPHYLACTIC PROTECTION AGAINST G-TYPE CHEMICAL WARFARE NERVE 
      AGENTS AND ORGANOPHOSPHOROUS COMPOUNDS

<130> 200563-0040-00-WO-572733

<140>
<141>

<150> 62/475,502
<151> 2017-03-23

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 7336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc      420

gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa      480

acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg      540

aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact      660

tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag      720

cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      780

tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc      840

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa      900

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc      960

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag     1020

accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc     1080

aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg     1140

aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc     1200

gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg     1320

ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     1440

gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     1500

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     1560

gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg     1620

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc     1680

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt     1740

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg     1800

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa     1860

caataaatga tttaaatcag gtatggctgc cgatggttat cttccagatt ggctcgagga     1920

caacctctct gagggcattc gcgagtggtg ggcgctgaaa cctggagccc cgaagcccaa     1980

agccaaccag caaaagcagg acgacggccg gggtctggtg cttcctggct acaagtacct     2040

cggacccttc aacggactcg acaaggggga gcccgtcaac gcggcggacg cagcggccct     2100

cgagcacgac aaggcctacg accagcagct gcaggcgggt gacaatccgt acctgcggta     2160

taaccacgcc gacgccgagt ttcaggagcg tctgcaagaa gatacgtctt ttgggggcaa     2220

cctcgggcga gcagtcttcc aggccaagaa gcgggttctc gaacctctcg gtctggttga     2280

ggaaggcgct aagacggctc ctggaaagaa gagaccggta gagccatcac cccagcgttc     2340

tccagactcc tctacgggca tcggcaagaa aggccaacag cccgccagaa aaagactcaa     2400

ttttggtcag actggcgact cagagtcagt tccagaccct caacctctcg gagaacctcc     2460

agcagcgccc tctggtgtgg gacctaatac aatggctgca ggcggtggcg caccaatggc     2520

agacaataac gaaggcgccg acggagtggg tagttcctcg ggaaattggc attgcgattc     2580

cacatggctg ggcgacagag tcatcaccac cagcacccga acctgggccc tgcccaccta     2640

caacaaccac ctctacaagc aaatctccaa cgggacatcg ggaggagcca ccaacgacaa     2700

cacctacttc ggctacagca ccccctgggg gtattttgac tttaacagat tccactgcca     2760

cttttcacca cgtgactggc agcgactcat caacaacaac tggggattcc ggcccaagag     2820

actcagcttc aagctcttca acatccaggt caaggaggtc acgcagaatg aaggcaccaa     2880

gaccatcgcc aataacctca ccagcaccat ccaggtgttt acggactcgg agtaccagct     2940

gccgtacgtt ctcggctctg cccaccaggg ctgcctgcct ccgttcccgg cggacgtgtt     3000

catgattccc cagtacggct acctaacact caacaacggt agtcaggccg tgggacgctc     3060

ctccttctac tgcctggaat actttccttc gcagatgctg agaaccggca acaacttcca     3120

gtttacttac accttcgagg acgtgccttt ccacagcagc tacgcccaca gccagagctt     3180

ggaccggctg atgaatcctc tgattgacca gtacctgtac tacttgtctc ggactcaaac     3240

aacaggaggc acggcaaata cgcagactct gggcttcagc caaggtgggc ctaatacaat     3300

ggccaatcag gcaaagaact ggctgccagg accctgttac cgccaacaac gcgtctcaac     3360

gacaaccggg caaaacaaca atagcaactt tgcctggact gctgggacca aataccatct     3420

gaatggaaga aattcattgg ctaatcctgg catcgctatg gcaacacaca aagacgacga     3480

ggagcgtttt tttcccagta acgggatcct gatttttggc aaacaaaatg ctgccagaga     3540

caatgcggat tacagcgatg tcatgctcac cagcgaggaa gaaatcaaaa ccactaaccc     3600

tgtggctaca gaggaatacg gtatcgtggc agataacttg cagcagcaaa acacggctcc     3660

tcaaattgga actgtcaaca gccagggggc cttacccggt atggtctggc agaaccggga     3720

cgtgtacctg cagggtccca tctgggccaa gattcctcac acggacggca acttccaccc     3780

gtctccgctg atgggcggct ttggcctgaa acatcctccg cctcagatcc tgatcaagaa     3840

cacgcctgta cctgcggatc ctccgaccac cttcaaccag tcaaagctga actctttcat     3900

cacgcaatac agcaccggac aggtcagcgt ggaaattgaa tgggagctgc agaaggaaaa     3960

cagcaagcgc tggaaccccg agatccagta cacctccaac tactacaaat ctacaagtgt     4020

ggactttgct gttaatacag aaggcgtgta ctctgaaccc cgccccattg gcacccgtta     4080

cctcacccgt aatctgtaat tgcctgttaa tcaataaacc ggttgattcg tttcagttga     4140

actttggtct ctgcgaaggg cgaattcgtt taaacctgca ggactagagg tcctgtatta     4200

gaggtcacgt gagtgttttg cgacattttg cgacaccatg tggtcacgct gggtatttaa     4260

gcccgagtga gcacgcaggg tctccatttt gaagcgggag gtttgaacgc gcagccgcca     4320

agccgaattc tgcagatatc catcacactg gcggccgctc gactagagcg gccgccaccg     4380

cggtggagct ccagcttttg ttccctttag tgagggttaa ttgcgcgctt ggcgtaatca     4440

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     4500

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     4560

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     4620

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc     4680

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     4740

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     4800

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     4860

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     4920

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     4980

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     5040

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     5100

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     5160

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     5220

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     5280

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     5340

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     5400

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     5460

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     5520

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     5580

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     5640

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata     5700

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg     5760

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct     5820

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt     5880

tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc     5940

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga     6000

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt     6060

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc     6120

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa     6180

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca     6240

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca     6300

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct     6360

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc     6420

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa     6480

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt     6540

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctaaattg     6600

taagcgttaa tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta     6660

accaataggc cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt     6720

tgagtgttgt tccagtttgg aacaagagtc cactattaaa gaacgtggac tccaacgtca     6780

aagggcgaaa aaccgtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa     6840

gttttttggg gtcgaggtgc cgtaaagcac taaatcggaa ccctaaaggg agcccccgat     6900

ttagagcttg acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag     6960

gagcgggcgc tagggcgctg gcaagtgtag cggtcacgct gcgcgtaacc accacacccg     7020

ccgcgcttaa tgcgccgcta cagggcgcgt cccattcgcc attcaggctg cgcaactgtt     7080

gggaagggcg atcggtgcgg gcctcttcgc tattacgcca gctggcgaaa gggggatgtg     7140

ctgcaaggcg attaagttgg gtaacgccag ggttttccca gtcacgacgt tgtaaaacga     7200

cggccagtga gcgcgcgtaa tacgactcac tatagggcga attgggtacc gggccccccc     7260

tcgatcgagg tcgacggtat cgggggagct cgcagggtct ccattttgaa gcgggaggtt     7320

tgaacgcgca gccgcc                                                     7336


<210> 2
<211> 750
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg      660

cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata      720

agcagagctc gtttagtgaa ccgtcagatc                                       750


<210> 3
<211> 1055
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc       60

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      120

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta      180

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      240

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      300

cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca tctccccccc      360

ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag cgatgggggc      420

gggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg      480

aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg      540

gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc gggagtcgct      600

gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc gccccggctc      660

tgactgaccg cgttactaaa acaggtaagt ccggcctccg cgccgggttt tggcgcctcc      720

cgcgggcgcc cccctcctca cggcgagcgc tgccacgtca gacgaagggc gcagcgagcg      780

tcctgatcct tccgcccgga cgctcaggac agcggcccgc tgctcataag actcggcctt      840

agaaccccag tatcagcaga aggacatttt aggacgggac ttgggtgact ctagggcact      900

ggttttcttt ccagagagcg gaacaggcga ggaaaagtag tcccttctcg gcgattctgc      960

ggagggatct ccgtggggcg gtgaacgccg atgatgcctc tactaaccat gttcatgttt     1020

tctttttttt tctacaggtc ctgggtgacg aacag                                1055


<210> 4
<211> 477
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
agggctggaa gctacctttg acatcatttc ctctgcgaat gcatgtataa tttctacaga       60

acctattaga aaggatcacc cagcctctgc ttttgtacaa ctttccctta aaaaactgcc      120

aattccactg ctgtttggcc caatagtgag aactttttcc tgctgcctct tggtgctttt      180

gcctatggcc cctattctgc ctgctgaaga cactcttgcc agcatggact taaacccctc      240

cagctctgac aatcctcttt ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat      300

cactcaaagt tcaaacctta tcattttttg ctttgttcct cttggccttg gttttgtaca      360

tcagctttga aaataccatc ccagggttaa tgctggggtt aatttataac taagagtgct      420

ctagttttgc aatacaggac atgctataaa aatggaaaga tgttgctttc tgagaga         477


<210> 5
<211> 1068
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atggccaagc tgaccgccct gacactgctg ggactcggtc tggctctctt tgacgggcag       60

aagtcttcct tccagacaag gttcaatgtt cacagagaag tcacccctgt tgagctgcca      120

aactgcaatc tggtgaaagg ggtcgacaat gggagcgagg acatggagat cctccctaat      180

ggactggcct tcatttcctc cggagtgaag tatccaggta ttatgagctt cgacccagat      240

aagtcaggga agatcctgct gatggacctg aacgaggagg accctgtcgt tctggaactc      300

ggaatcaccg gcaacacact cgacatatct tcctttaatc ctgctggcat tagcaccttc      360

acagatgaag acaacacagt ctacctgctc gtcgtcaata ggcctgattc ttcctcaacc      420

gttgaggtgt tcaagtttca agaagaggag aagtctctgc tgcatctgaa aacaatcaga      480

cataaactgc tgcccagcgt gaatgatatc gtggccgttg ggcctgagca cttttatgct      540

acaaatgacc attactttgc tgacccttac ctgaaatctt gggaaatgca cctcggcctg      600

gcctggagct ttgtgacata ctattcccca aacgatgtca gggtcgttgc agaaggtttc      660

gacatggcta atggaatcaa tatctctcca gacgggaagt atgtttacat cgccgagctg      720

ctggcccaca agatccatgt ttatgaaaag cacgcaaact ggaccctgac acctctgaag      780

tccctcgact tcgacacact cgtcgacaac atctccgtgg acccagtgac cggggacctg      840

tgggtgggct gtcatcccaa tggaatgaga ctgttctatt acgacccaaa gaacccaccc      900

ggcagcgagg tgctgagaat ccaagatatc ctctctgagg aacctaaggt caccgtcgtg      960

tatgccgaga acggaacagt tctgcaaggc agcagcgtgg ctgcagtcta caaaggcaaa     1020

ctcctgattg gaacagtgtt ccacaaggct ctgtattgcg agctgtaa                  1068


<210> 6
<211> 355
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Met Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210> 7
<211> 355
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 
