                         SEQUENCE LISTING

<110>  Probiodrug AG
 
<120>  Novel inhibitors

<130>  PBD132WO

<150>  GB 1705263.0
<151>  2017-03-31

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  2
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  3
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly Val Val Ile Ala 
        35                  40  


<210>  4
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly Val Val 
        35              


<210>  5
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  5

Gln Gly Pro Trp Leu Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met Asp 
1               5                   10                  15      


Phe 
    


<210>  6
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  7

Gln His Trp Ser Tyr Gly Leu Arg Pro Gly 
1               5                   10  


<210>  8
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Pro Lys Val Pro Glu Trp Val Asn Thr Pro Ser Thr Cys Cys Leu 
1               5                   10                  15      


Lys Tyr Tyr Glu Lys Val Leu Pro Arg Arg Leu Val Val Gly Tyr Arg 
            20                  25                  30          


Lys Ala Leu Asn Cys His Leu Pro Ala Ile Ile Phe Val Thr Lys Arg 
        35                  40                  45              


Asn Arg Glu Val Cys Thr Asn Pro Asn Asp Asp Trp Val Gln Glu Tyr 
    50                  55                  60                  


Ile Lys Asp Pro Asn Leu Pro Leu Leu Pro Thr Arg Asn Leu Ser Thr 
65                  70                  75                  80  


Val Lys Ile Ile Thr Ala Lys Asn Gly Gln Pro Gln Leu Leu Asn Ser 
                85                  90                  95      


Gln 
    


<210>  9
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Pro Asp Ser Val Ser Ile Pro Ile Thr Cys Cys Phe Asn Val Ile 
1               5                   10                  15      


Asn Arg Lys Ile Pro Ile Gln Arg Leu Glu Ser Tyr Thr Arg Ile Thr 
            20                  25                  30          


Asn Ile Gln Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Lys Arg Gly 
        35                  40                  45              


Lys Glu Val Cys Ala Asp Pro Lys Glu Arg Trp Val Arg Asp Ser Met 
    50                  55                  60                  


Lys His Leu Asp Gln Ile Phe Gln Asn Leu Lys Pro 
65                  70                  75      


<210>  10
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 
1               5                   10                  15      


Asn Arg Lys Ile Ser Val Gln Arg Leu Ala Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Ser Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Val Ala 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 
    50                  55                  60                  


Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75      


<210>  11
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Val Gly Thr Asn Lys Glu Leu Cys Cys Leu Val Tyr Thr Ser Trp 
1               5                   10                  15      


Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser Glu Thr Ser Pro Gln 
            20                  25                  30          


Cys Pro Lys Pro Gly Val Ile Leu Leu Thr Lys Arg Gly Arg Gln Ile 
        35                  40                  45              


Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys Tyr Ile Ser Asp Leu 
    50                  55                  60                  


Lys Leu Asn Ala 
65              


<210>  12
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met Thr 
1               5                   10                  15      


Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln Ala 
            20                  25                  30          


Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg Leu 
        35                  40                  45              


Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln His 
    50                  55                  60                  


Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Thr Phe Glu 
65                  70                  75                  80  


Lys Gln Ile Gly Glu Val Lys Pro Arg Thr Thr Pro Ala Ala Gly Gly 
                85                  90                  95      


Met Asp Glu Ser Val Val Leu Glu Pro Glu Ala Thr Gly Glu Ser Ser 
            100                 105                 110         


Ser Leu Glu Pro Thr Pro Ser Ser Gln Glu Ala Gln Arg Ala Leu Gly 
        115                 120                 125             


Thr Ser Pro Glu Leu Pro Thr Gly Val Thr Gly Ser Ser Gly Thr Arg 
    130                 135                 140                 


Leu Pro Pro Thr Pro Lys Ala Gln Asp Gly Gly Pro Val Gly Thr Glu 
145                 150                 155                 160 


Leu Phe Arg Val Pro Pro Val Ser Thr Ala Ala Thr Trp Gln Ser Ser 
                165                 170                 175     


Ala Pro His Gln Pro Gly Pro Ser Leu Trp Ala Glu Ala Lys Thr Ser 
            180                 185                 190         


Glu Ala Pro Ser Thr Gln Asp Pro Ser Thr Gln Ala Ser Thr Ala Ser 
        195                 200                 205             


Ser Pro Ala Pro Glu Glu Asn Ala Pro Ser Glu Gly Gln Arg Val Trp 
    210                 215                 220                 


Gly Gln Gly Gln Ser Pro Arg Pro Glu Asn Ser Leu Glu Arg Glu Glu 
225                 230                 235                 240 


Met Gly Pro Val Pro Ala His Thr Asp Ala Phe Gln Asp Trp Gly Pro 
                245                 250                 255     


Gly Ser Met Ala His Val Ser Val Val Pro Val Ser Ser Glu Gly Thr 
            260                 265                 270         


Pro Ser Arg Glu Pro Val Ala Ser Gly Ser Trp Thr Pro Lys Ala Glu 
        275                 280                 285             


Glu Pro Ile His Ala Thr Met Asp Pro Gln Arg Leu Gly Val Leu Ile 
    290                 295                 300                 


Thr Pro Val Pro Asp Ala Gln Ala Ala Thr Arg Arg Gln Ala Val Gly 
305                 310                 315                 320 


Leu Leu Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly Val Ala Met Phe 
                325                 330                 335     


Thr Tyr Gln Ser Leu Gln Gly Cys Pro Arg Lys Met Ala Gly Glu Met 
            340                 345                 350         


Ala Glu Gly Leu Arg Tyr Ile Pro Arg Ser Cys Gly Ser Asn Ser Tyr 
        355                 360                 365             


Val Leu Val Pro Val 
    370             


<210>  13
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Pro Val Gly Ile Asn Thr Ser Thr Thr Cys Cys Tyr Arg Phe Ile 
1               5                   10                  15      


Asn Lys Lys Ile Pro Lys Gln Arg Leu Glu Ser Tyr Arg Arg Thr Thr 
            20                  25                  30          


Ser Ser His Cys Pro Arg Glu Ala Val Ile Phe Lys Thr Lys Leu Asp 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Thr Gln Lys Trp Val Gln Asp Phe Met 
    50                  55                  60                  


Lys His Leu Asp Lys Lys Thr Gln Thr Pro Lys Leu 
65                  70                  75      


<210>  14
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 
1               5                   10                  15      


Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 
            20                  25                  30          


Leu 
    


<210>  15
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met 
1               5                   10      


<210>  16
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  16

Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser 
1               5                   10                  15      


Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
            20                  25                  30          


<210>  17
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  17

Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser 
1               5                   10                  15      


Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val 
            20                  25                  30  


<210>  18
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  18

Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn Lys Phe Ala 
1               5                   10                  15      


Val Glu Thr Leu Ile Cys Ser Arg Thr Val Lys Lys Asn Ile Ile Glu 
            20                  25                  30          


Glu Asn 
        


<210>  19
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  19

Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn Lys Phe Ala 
1               5                   10                  15      


Val Glu Thr Leu Ile Cys Phe Asn Leu Phe Leu Asn Ser Gln Glu Lys 
            20                  25                  30          


His Tyr 
        


<210>  20
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  20

Gln Tyr Asn Ala Asp 
1               5   


