                         SEQUENCE LISTING

<110>  Imperial Innovations Limited
 
<120>  Natural Killer Cells

<130>  P48972WO

<150>  GB 1704953.7
<151>  2017-03-28

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcggcag cgtcccggag cgcctctggc tgggcgctac tgctgctggt ggcactttgg       60

cagcagcgcg cggccggctc cggcgtcttc cagctgcagc tgcaggagtt catcaacgag      120

cgcggcgtac tggccagtgg gcggccttgc gagcccggct gccggacttt cttccgcgtc      180

tgccttaagc acttccaggc ggtcgtctcg cccggaccct gcaccttcgg gaccgtctcc      240

acgccggtat tgggcaccaa ctccttcgct gtccgggacg acagtagcgg cggggggcgc      300

aaccctctcc aactgccctt caatttcacc tggccgggta ccttctcgct catcatcgaa      360

gcttggcacg cgccaggaga cgacctgcgg ccagaggcct tgccaccaga tgcactcatc      420

agcaagatcg ccatccaggg ctccctagct gtgggtcaga actggttatt ggatgagcaa      480

accagcaccc tcacaaggct gcgctactct taccgggtca tctgcagtga caactactat      540

ggagacaact gctcccgcct gtgcaagaag cgcaatgacc acttcggcca ctatgtgtgc      600

cagccagatg gcaacttgtc ctgcctgccc ggttggactg gggaatattg ccaacagcct      660

atctgtcttt cgggctgtca tgaacagaat ggctactgca gcaagccagc agagtgcctc      720

tgccgcccag gctggcaggg ccggctgtgt aacgaatgca tcccccacaa tggctgtcgc      780

cacggcacct gcagcactcc ctggcaatgt acttgtgatg agggctgggg aggcctgttt      840

tgtgaccaag atctcaacta ctgcacccac cactccccat gcaagaatgg ggcaacgtgc      900

tccaacagtg ggcagcgaag ctacacctgc acctgtcgcc caggctacac tggtgtggac      960

tgtgagctgg agctcagcga gtgtgacagc aacccctgtc gcaatggagg cagctgtaag     1020

gaccaggagg atggctacca ctgcctgtgt cctccgggct actatggcct gcattgtgaa     1080

cacagcacct tgagctgcgc cgactccccc tgcttcaatg ggggctcctg ccgggagcgc     1140

aaccaggggg ccaactatgc ttgtgaatgt ccccccaact tcaccggctc caactgcgag     1200

aagaaagtgg acaggtgcac cagcaacccc tgtgccaacg ggggacagtg cctgaaccga     1260

ggtccaagcc gcatgtgccg ctgccgtcct ggattcacgg gcacctactg tgaactccac     1320

gtcagcgact gtgcccgtaa cccttgcgcc cacggtggca cttgccatga cctggagaat     1380

gggctcatgt gcacctgccc tgccggcttc tctggccgac gctgtgaggt gcggacatcc     1440

atcgatgcct gtgcctcgag tccctgcttc aacagggcca cctgctacac cgacctctcc     1500

acagacacct ttgtgtgcaa ctgcccttat ggctttgtgg gcagccgctg cgagttcccc     1560

gtgggcttgc cgcccagctt cccctgggtg gccgtctcgc tgggtgtggg gctggcagtg     1620

ctgctggtac tgctgggcat ggtggcagtg gctgtgcggc agctgcggct tcgacggccg     1680

gacgacggca gcagggaagc catgaacaac ttgtcggact tccagaagga caacctgatt     1740

cctgccgccc agcttaaaaa cacaaaccag aagaaggagc tggaagtgga ctgtggcctg     1800

gacaagtcca actgtggcaa acagcaaaac cacacattgg actataatct ggccccaggg     1860

cccctggggc gggggaccat gccaggaaag tttccccaca gtgacaagag cttaggagag     1920

aaggcgccac tgcggttaca cagtgaaaag ccagagtgtc ggatatcagc gatatgctcc     1980

cccagggact ccatgtacca gtctgtgtgt ttgatatcag aggagaggaa tgaatgtgtc     2040

attgccacgg aggtataa                                                   2058


<210>  2
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro 
        515                 520                 525             


Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu 
    530                 535                 540                 


Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro 
545                 550                 555                 560 


Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys 
                565                 570                 575     


Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys 
            580                 585                 590         


Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln 
        595                 600                 605             


Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg 
    610                 615                 620                 


Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu 
625                 630                 635                 640 


Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser 
                645                 650                 655     


Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile 
            660                 665                 670         


Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
        675                 680                 685 


<210>  3
<211>  1923
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1833)..(1833)
<223>  n is a, c, g, or t

<400>  3
gcccctttct ttctcctcgt cggcccgaga gcaggaacac gataacgaag gaggcccaac       60

ttcattcaat aaggagcctg acggatttat cccagacggt agaacaaaag gaagaatatt      120

gatggatttt aaaccagagt ttttaaagag cttgagaata cggggaaatt aatttgttct      180

cctacacaca tagatagggt aaggttgttt ctgatgcagc tgagaaaaat gcagaccgtc      240

aaaaaggagc aggcgtctct tgatgccagt agcaatgtgg acaagatgat ggtccttaat      300

tctgctttaa cggaagtgtc agaagactcc acaacaggtg aggacgtgct tctcagtgaa      360

ggaagtgtgg ggaagaacaa atcttctgca tgtcggagga aacgggaatt cattcctgat      420

gaaaagaaag atgctatgta ttgggaaaaa aggcggaaaa ataatgaagc tgccaaaaga      480

tctcgtgaga agcgtcgact gaatgacctg gttttagaga acaaactaat tgcactggga      540

gaagaaaacg ccactttaaa agctgagctg ctttcactaa aattaaagtt tggtttaatt      600

agctccacag catatgctca agagattcag aaactcagta attctacagc tgtgtacttt      660

caagattacc agacttccaa atccaatgtg agttcatttg tggacgagca cgaaccctcg      720

atggtgtcaa gtagttgtat ttctgtcatt aaacactctc cacaaagctc gctgtccgat      780

gtttcagaag tgtcctcagt agaacacacg caggagagct ctgtgcaggg aagctgcaga      840

agtcctgaaa acaagttcca gattatcaag caagagccga tggaattaga gagctacaca      900

agggagccaa gagatgaccg aggctcttac acagcgtcca tctatcaaaa ctatatgggg      960

aattctttct ctgggtactc acactctccc ccactactgc aagtcaaccg atcctccagc     1020

aactccccga gaacgtcgga aactgatgat ggtgtggtag gaaagtcatc tgatggagaa     1080

gacgagcaac aggtccccaa gggccccatc cattctccag ttgaactcaa gcatgtgcat     1140

gcaactgtgg ttaaagttcc agaagtgaat tcctctgcct tgccacacaa gctccggatc     1200

aaagccaaag ccatgcagat caaagtagaa gcctttgata atgaatttga ggccacgcaa     1260

aaactttcct cacctattga catgacatct aaaagacatt tcgaactcga aaagcatagt     1320

gccccaagta tggtacattc ttctcttact cctttctcag tgcaagtgac taacattcaa     1380

gattggtctc tcaaatcgga gcactggcat caaaaagaac tgagtggcaa aactcagaat     1440

agtttcaaaa ctggagttgt tgaaatgaaa gacagtggct acaaagtttc tgacccagag     1500

aacttgtatt tgaagcaggg gatagcaaac ttatctgcag aggttgtctc actcaagaga     1560

cttatagcca cacaaccaat ctctgcttca gactctgggt aaattactac tgagtaagag     1620

ctgggcattt agaaagatgt catttgcaat agagcagtcc attttgtatt atgctgaatt     1680

ttcactggac ctgtgatgtc atttcactgt gatgtgcaca tgttgtctgt ttggtgtctt     1740

tttgtgcaca gattatgatg aagattagat tgtgttatca ctctgcctgt gtatagtcag     1800

atagtcatat gcgtaaggct gtatatatta agnttttatt tttgttgttc tattataaag     1860

tgtgtaagtt accagtttca ataaaggatt ggtgacaaac acagaaaaaa aaaaaaaaaa     1920

aaa                                                                   1923


<210>  4
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Leu Arg Lys Met Gln Thr Val Lys Lys Glu Gln Ala Ser Leu 
1               5                   10                  15      


Asp Ala Ser Ser Asn Val Asp Lys Met Met Val Leu Asn Ser Ala Leu 
            20                  25                  30          


Thr Glu Val Ser Glu Asp Ser Thr Thr Gly Glu Asp Val Leu Leu Ser 
        35                  40                  45              


Glu Gly Ser Val Gly Lys Asn Lys Ser Ser Ala Cys Arg Arg Lys Arg 
    50                  55                  60                  


Glu Phe Ile Pro Asp Glu Lys Lys Asp Ala Met Tyr Trp Glu Lys Arg 
65                  70                  75                  80  


Arg Lys Asn Asn Glu Ala Ala Lys Arg Ser Arg Glu Lys Arg Arg Leu 
                85                  90                  95      


Asn Asp Leu Val Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn 
            100                 105                 110         


Ala Thr Leu Lys Ala Glu Leu Leu Ser Leu Lys Leu Lys Phe Gly Leu 
        115                 120                 125             


Ile Ser Ser Thr Ala Tyr Ala Gln Glu Ile Gln Lys Leu Ser Asn Ser 
    130                 135                 140                 


Thr Ala Val Tyr Phe Gln Asp Tyr Gln Thr Ser Lys Ser Asn Val Ser 
145                 150                 155                 160 


Ser Phe Val Asp Glu His Glu Pro Ser Met Val Ser Ser Ser Cys Ile 
                165                 170                 175     


Ser Val Ile Lys His Ser Pro Gln Ser Ser Leu Ser Asp Val Ser Glu 
            180                 185                 190         


Val Ser Ser Val Glu His Thr Gln Glu Ser Ser Val Gln Gly Ser Cys 
        195                 200                 205             


Arg Ser Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Met Glu 
    210                 215                 220                 


Leu Glu Ser Tyr Thr Arg Glu Pro Arg Asp Asp Arg Gly Ser Tyr Thr 
225                 230                 235                 240 


Ala Ser Ile Tyr Gln Asn Tyr Met Gly Asn Ser Phe Ser Gly Tyr Ser 
                245                 250                 255     


His Ser Pro Pro Leu Leu Gln Val Asn Arg Ser Ser Ser Asn Ser Pro 
            260                 265                 270         


Arg Thr Ser Glu Thr Asp Asp Gly Val Val Gly Lys Ser Ser Asp Gly 
        275                 280                 285             


Glu Asp Glu Gln Gln Val Pro Lys Gly Pro Ile His Ser Pro Val Glu 
    290                 295                 300                 


Leu Lys His Val His Ala Thr Val Val Lys Val Pro Glu Val Asn Ser 
305                 310                 315                 320 


Ser Ala Leu Pro His Lys Leu Arg Ile Lys Ala Lys Ala Met Gln Ile 
                325                 330                 335     


Lys Val Glu Ala Phe Asp Asn Glu Phe Glu Ala Thr Gln Lys Leu Ser 
            340                 345                 350         


Ser Pro Ile Asp Met Thr Ser Lys Arg His Phe Glu Leu Glu Lys His 
        355                 360                 365             


Ser Ala Pro Ser Met Val His Ser Ser Leu Thr Pro Phe Ser Val Gln 
    370                 375                 380                 


Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His Gln 
385                 390                 395                 400 


Lys Glu Leu Ser Gly Lys Thr Gln Asn Ser Phe Lys Thr Gly Val Val 
                405                 410                 415     


Glu Met Lys Asp Ser Gly Tyr Lys Val Ser Asp Pro Glu Asn Leu Tyr 
            420                 425                 430         


Leu Lys Gln Gly Ile Ala Asn Leu Ser Ala Glu Val Val Ser Leu Lys 
        435                 440                 445             


Arg Leu Ile Ala Thr Gln Pro Ile Ser Ala Ser Asp Ser Gly 
    450                 455                 460         


<210>  5
<211>  2793
<212>  DNA
<213>  Homo sapiens

<400>  5
gggcacgagg cgctccctgg gatcacatgg tacctgctcc agtgccgcgt gcggcccggg       60

aaccctgggc tgctggcgcc tgcgcagagc cctctgtccc agggaaaggc tcgggcaaaa      120

ggcggctgag attggcagag tgaaatatta ctgccgaggg aacgtagcag ggcacacgtc      180

tcgcctcttt gcgactcggt gccccgtttc tccccatcac ctacttactt cctggttgca      240

acctctcttc ctctgggact tttgcaccgg gagctccaga ttcgccaccc cgcagcgctg      300

cggagccggc aggcagaggc accccgtaca ctgcagagac ccgaccctcc ttgctacctt      360

ctagccagaa ctactgcagg ctgattcccc ctacacactc tctctgctct tcccatgcaa      420

agcagaactc cgttgcctca acgtccaacc cttctgcagg gctgcagtcc ggccacccca      480

agaccttgct gcagggtgct tcggatcctg atcgtgagtc gcggggtcca ctccccgccc      540

ttagccagtg cccagggggc aacagcggcg atcgcaacct ctagtttgag tcaaggtcca      600

gtttgaatga ccgctctcag ctggtgaaga catgacgacc ctggactcca acaacaacac      660

aggtggcgtc atcacctaca ttggctccag tggctcctcc ccaagccgca ccagccctga      720

atccctctat agtgacaact ccaatggcag cttccagtcc ctgacccaag gctgtcccac      780

ctacttccca ccatccccca ctggctccct cacccaagac ccggctcgct cctttgggag      840

cattccaccc agcctgagtg atgacggctc cccttcttcc tcatcttcct cgtcgtcatc      900

ctcctcctcc ttctataatg ggagcccccc tgggagtcta caagtggcca tggaggacag      960

cagccgagtg tcccccagca agagcaccag caacatcacc aagctgaatg gcatggtgtt     1020

actgtgtaaa gtgtgtgggg acgttgcctc gggcttccac tacggtgtgc acgcctgcga     1080

gggctgcaag ggctttttcc gtcggagcat ccagcagaac atccagtaca aaaggtgtct     1140

gaagaatgag aattgctcca tcgtccgcat caatcgcaac cgctgccagc aatgtcgctt     1200

caagaagtgt ctctctgtgg gcatgtctcg agacgctgtg cgttttgggc gcatccccaa     1260

acgagagaag cagcggatgc ttgctgagat gcagagtgcc atgaacctgg ccaacaacca     1320

gttgagcagc cagtgcccgc tggagacttc acccacccag caccccaccc caggccccat     1380

gggcccctcg ccaccccctg ctccggtccc ctcacccctg gtgggcttct cccagtttcc     1440

acaacagctg acgcctccca gatccccaag ccctgagccc acagtggagg atgtgatatc     1500

ccaggtggcc cgggcccatc gagagatctt cacctacgcc catgacaagc tgggcagctc     1560

acctggcaac ttcaatgcca accatgcatc aggtagccct ccagccacca ccccacatcg     1620

ctgggaaaat cagggctgcc cacctgcccc caatgacaac aacaccttgg ctgcccagcg     1680

tcataacgag gccctaaatg gtctgcgcca ggctccctcc tcctaccctc ccacctggcc     1740

tcctggccct gcacaccaca gctgccacca gtccaacagc aacgggcacc gtctatgccc     1800

cacccacgtg tatgcagccc cagaaggcaa ggcacctgcc aacagtcccc ggcagggcaa     1860

ctcaaagaat gttctgctgg catgtcctat gaacatgtac ccgcatggac gcagtgggcg     1920

aacggtgcag gagatctggg aggatttctc catgagcttc acgcccgctg tgcgggaggt     1980

ggtagagttt gccaaacaca tcccgggctt ccgtgacctt tctcagcatg accaagtcac     2040

cctgcttaag gctggcacct ttgaggtgct gatggtgcgc tttgcttcgt tgttcaacgt     2100

gaaggaccag acagtgatgt tcctaagccg caccacctac agcctgcagg agcttggtgc     2160

catgggcatg ggagacctgc tcagtgccat gttcgacttc agcgagaagc tcaactccct     2220

ggcgcttacc gaggaggagc tgggcctctt caccgcggtg gtgcttgtct ctgcagaccg     2280

ctcgggcatg gagaattccg cttcggtgga gcagctccag gagacgctgc tgcgggctct     2340

tcgggctctg gtgctgaaga accggccctt ggagacttcc cgcttcacca agctgctgct     2400

caagctgccg gacctgcgga ccctgaacaa catgcattcc gagaagctgc tgtccttccg     2460

ggtggacgcc cagtgacccg cccggccggc cttctgccgc tgcccccttg tacagaatcg     2520

aactctgcac ttctctctcc tttacgagac gaaaaggaaa agcaaaccag aatcttattt     2580

atattgttat aaaatattcc aagatgagcc tctggccccc tgagccttct tgtaaatacc     2640

tgcctccctc ccccatcacc gaacttcccc tcctccccta tttaaaccac tctgtctccc     2700

ccacaaccct cccctggccc tctgatttgt tctgttcctg tctcaaatcc aatagttcac     2760

agctgagctg gcttcaaaaa aaaaaaaaaa aaa                                  2793


<210>  6
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Thr Leu Asp Ser Asn Asn Asn Thr Gly Gly Val Ile Thr Tyr 
1               5                   10                  15      


Ile Gly Ser Ser Gly Ser Ser Pro Ser Arg Thr Ser Pro Glu Ser Leu 
            20                  25                  30          


Tyr Ser Asp Asn Ser Asn Gly Ser Phe Gln Ser Leu Thr Gln Gly Cys 
        35                  40                  45              


Pro Thr Tyr Phe Pro Pro Ser Pro Thr Gly Ser Leu Thr Gln Asp Pro 
    50                  55                  60                  


Ala Arg Ser Phe Gly Ser Ile Pro Pro Ser Leu Ser Asp Asp Gly Ser 
65                  70                  75                  80  


Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Phe Tyr Asn 
                85                  90                  95      


Gly Ser Pro Pro Gly Ser Leu Gln Val Ala Met Glu Asp Ser Ser Arg 
            100                 105                 110         


Val Ser Pro Ser Lys Ser Thr Ser Asn Ile Thr Lys Leu Asn Gly Met 
        115                 120                 125             


Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly Phe His Tyr 
    130                 135                 140                 


Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile 
145                 150                 155                 160 


Gln Gln Asn Ile Gln Tyr Lys Arg Cys Leu Lys Asn Glu Asn Cys Ser 
                165                 170                 175     


Ile Val Arg Ile Asn Arg Asn Arg Cys Gln Gln Cys Arg Phe Lys Lys 
            180                 185                 190         


Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe Gly Arg Ile 
        195                 200                 205             


Pro Lys Arg Glu Lys Gln Arg Met Leu Ala Glu Met Gln Ser Ala Met 
    210                 215                 220                 


Asn Leu Ala Asn Asn Gln Leu Ser Ser Gln Cys Pro Leu Glu Thr Ser 
225                 230                 235                 240 


Pro Thr Gln His Pro Thr Pro Gly Pro Met Gly Pro Ser Pro Pro Pro 
                245                 250                 255     


Ala Pro Val Pro Ser Pro Leu Val Gly Phe Ser Gln Phe Pro Gln Gln 
            260                 265                 270         


Leu Thr Pro Pro Arg Ser Pro Ser Pro Glu Pro Thr Val Glu Asp Val 
        275                 280                 285             


Ile Ser Gln Val Ala Arg Ala His Arg Glu Ile Phe Thr Tyr Ala His 
    290                 295                 300                 


Asp Lys Leu Gly Ser Ser Pro Gly Asn Phe Asn Ala Asn His Ala Ser 
305                 310                 315                 320 


Gly Ser Pro Pro Ala Thr Thr Pro His Arg Trp Glu Asn Gln Gly Cys 
                325                 330                 335     


Pro Pro Ala Pro Asn Asp Asn Asn Thr Leu Ala Ala Gln Arg His Asn 
            340                 345                 350         


Glu Ala Leu Asn Gly Leu Arg Gln Ala Pro Ser Ser Tyr Pro Pro Thr 
        355                 360                 365             


Trp Pro Pro Gly Pro Ala His His Ser Cys His Gln Ser Asn Ser Asn 
    370                 375                 380                 


Gly His Arg Leu Cys Pro Thr His Val Tyr Ala Ala Pro Glu Gly Lys 
385                 390                 395                 400 


Ala Pro Ala Asn Ser Pro Arg Gln Gly Asn Ser Lys Asn Val Leu Leu 
                405                 410                 415     


Ala Cys Pro Met Asn Met Tyr Pro His Gly Arg Ser Gly Arg Thr Val 
            420                 425                 430         


Gln Glu Ile Trp Glu Asp Phe Ser Met Ser Phe Thr Pro Ala Val Arg 
        435                 440                 445             


Glu Val Val Glu Phe Ala Lys His Ile Pro Gly Phe Arg Asp Leu Ser 
    450                 455                 460                 


Gln His Asp Gln Val Thr Leu Leu Lys Ala Gly Thr Phe Glu Val Leu 
465                 470                 475                 480 


Met Val Arg Phe Ala Ser Leu Phe Asn Val Lys Asp Gln Thr Val Met 
                485                 490                 495     


Phe Leu Ser Arg Thr Thr Tyr Ser Leu Gln Glu Leu Gly Ala Met Gly 
            500                 505                 510         


Met Gly Asp Leu Leu Ser Ala Met Phe Asp Phe Ser Glu Lys Leu Asn 
        515                 520                 525             


Ser Leu Ala Leu Thr Glu Glu Glu Leu Gly Leu Phe Thr Ala Val Val 
    530                 535                 540                 


Leu Val Ser Ala Asp Arg Ser Gly Met Glu Asn Ser Ala Ser Val Glu 
545                 550                 555                 560 


Gln Leu Gln Glu Thr Leu Leu Arg Ala Leu Arg Ala Leu Val Leu Lys 
                565                 570                 575     


Asn Arg Pro Leu Glu Thr Ser Arg Phe Thr Lys Leu Leu Leu Lys Leu 
            580                 585                 590         


Pro Asp Leu Arg Thr Leu Asn Asn Met His Ser Glu Lys Leu Leu Ser 
        595                 600                 605             


Phe Arg Val Asp Ala Gln 
    610                 


<210>  7
<211>  1740
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (994)..(994)
<223>  n is a, c, g, or t

<400>  7
atggaggtga atgcaggagg tgtgattgcc tatatcagtt cttccagctc agcctcaagc       60

cctgcctctt gtcacagtga gggttctgag aatagtttcc agtcctcctc ctcttctgtt      120

ccatcttctc caaatagctc taattctgat accaatggta atcccaagaa tggtgatctc      180

gccaatattg aaggcatctt gaagaatgat cgaatagatt gttctatgaa aacaagcaaa      240

tcgagtgcac ctgggatgac aaaaaatcat agtggtgtga caaaatttag tggcatggtt      300

ctactgtgta aagtctgtgg ggatgtggcg tcaggattcc actatggagt tcatgcttgc      360

gaaggctgta agggtttctt tcggagaagt attcaacaaa acatccagta caagaagtgc      420

ctgaagaatg aaaactgttc tataatgaga atgaatagga acagatgtca gcaatgtcgc      480

ttcaaaaagt gtctgtctgt tggaatgtca agagatgctg ttcggtttgg tcgtattcct      540

aagcgtgaaa aacagaggat gctaattgaa atgcaaagtg caatgaagac catgatgaac      600

agccagttca gtggtcactt gcaaaatgac acattagtag aacatcatga acagacagcc      660

ttgccagccc aggaacagct gcgacccaag ccccaactgg agcaagaaaa catcaaaagc      720

tcttctcctc catcttctga ttttgcaaag gaagaagtga ttggcatggt gaccagagct      780

cacaaggata cctttatgta taatcaagag cagcaagaaa actcagctga gagcatgcag      840

ccccagagag gagaacggat tcccaagaac atggagcaat ataatttaaa tcatgatcat      900

tgcggcaatg ggcttagcag ccattttccc tgtagtgaga gccagcagca tctcaatgga      960

cagttcaaag ggaggaatat aatgcattac ccanatggcc atgccatttg tattgcaaat     1020

ggacattgta tgaacttctc caatgcttat actcaaagag tatgtgatag agttccgata     1080

gatggatttt ctcagaatga gaacaagaat agttacctgt gcaacactgg aggaagaatg     1140

catctggttt gtccaatgag taagtctcca tatgtggatc ctcataaatc aggacatgaa     1200

atctgggaag aattttcgat gagcttcact ccagcagtga aagaagtggt ggaatttgca     1260

aagcgtattc ctgggttcag agatctctct cagcatgacc aggtcaacct tttaaaggct     1320

gggacttttg aggttttaat ggtacggttc gcatcattat ttgatgcaaa ggaacgtact     1380

gtcacctttt taagtggaaa gaaatatagt gtggatgatt tacactcaat gggagcaggg     1440

gatctgctaa actctatgtt tgaatttagt gagaagctaa atgccctcca acttagtgat     1500

gaagagatga gtttgtttac agctgttgtc ctggtatctg cagatcgatc tggaatagaa     1560

aacgtcaact ctgtggaggc tttgcaggaa actctcattc gtgcactaag gaccttaata     1620

atgaaaaacc atccaaatga ggcctctatt tttacaaaac tgcttctaaa gttgccagat     1680

cttcgatctt taaacaacat gcactctgag gagctcttgg cctttaaagt tcacccttaa     1740


<210>  8
<211>  578
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (332)..(332)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Met Glu Val Asn Ala Gly Gly Val Ile Ala Tyr Ile Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ala Ser Ser Pro Ala Ser Cys His Ser Glu Gly Ser Glu Asn Ser 
            20                  25                  30          


Phe Gln Ser Ser Ser Ser Ser Val Pro Ser Ser Pro Asn Ser Ser Asn 
        35                  40                  45              


Ser Asp Thr Asn Gly Asn Pro Lys Asn Gly Asp Leu Ala Asn Ile Glu 
    50                  55                  60                  


Gly Ile Leu Lys Asn Asp Arg Ile Asp Cys Ser Met Lys Thr Ser Lys 
65                  70                  75                  80  


Ser Ser Ala Pro Gly Met Thr Lys Asn His Ser Gly Val Thr Lys Phe 
                85                  90                  95      


Ser Gly Met Val Leu Leu Cys Lys Val Cys Gly Asp Val Ala Ser Gly 
            100                 105                 110         


Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg 
        115                 120                 125             


Arg Ser Ile Gln Gln Asn Ile Gln Tyr Lys Lys Cys Leu Lys Asn Glu 
    130                 135                 140                 


Asn Cys Ser Ile Met Arg Met Asn Arg Asn Arg Cys Gln Gln Cys Arg 
145                 150                 155                 160 


Phe Lys Lys Cys Leu Ser Val Gly Met Ser Arg Asp Ala Val Arg Phe 
                165                 170                 175     


Gly Arg Ile Pro Lys Arg Glu Lys Gln Arg Met Leu Ile Glu Met Gln 
            180                 185                 190         


Ser Ala Met Lys Thr Met Met Asn Ser Gln Phe Ser Gly His Leu Gln 
        195                 200                 205             


Asn Asp Thr Leu Val Glu His His Glu Gln Thr Ala Leu Pro Ala Gln 
    210                 215                 220                 


Glu Gln Leu Arg Pro Lys Pro Gln Leu Glu Gln Glu Asn Ile Lys Ser 
225                 230                 235                 240 


Ser Ser Pro Pro Ser Ser Asp Phe Ala Lys Glu Glu Val Ile Gly Met 
                245                 250                 255     


Val Thr Arg Ala His Lys Asp Thr Phe Met Tyr Asn Gln Glu Gln Gln 
            260                 265                 270         


Glu Asn Ser Ala Glu Ser Met Gln Pro Gln Arg Gly Glu Arg Ile Pro 
        275                 280                 285             


Lys Asn Met Glu Gln Tyr Asn Leu Asn His Asp His Cys Gly Asn Gly 
    290                 295                 300                 


Leu Ser Ser His Phe Pro Cys Ser Glu Ser Gln Gln His Leu Asn Gly 
305                 310                 315                 320 


Gln Phe Lys Gly Arg Asn Ile Met His Tyr Pro Xaa Gly His Ala Ile 
                325                 330                 335     


Cys Ile Ala Asn Gly His Cys Met Asn Phe Ser Asn Ala Tyr Thr Gln 
            340                 345                 350         


Arg Val Cys Asp Arg Val Pro Ile Asp Gly Phe Ser Gln Asn Glu Asn 
        355                 360                 365             


Lys Asn Ser Tyr Leu Cys Asn Thr Gly Gly Arg Met His Leu Val Cys 
    370                 375                 380                 


Pro Met Ser Lys Ser Pro Tyr Val Asp Pro His Lys Ser Gly His Glu 
385                 390                 395                 400 


Ile Trp Glu Glu Phe Ser Met Ser Phe Thr Pro Ala Val Lys Glu Val 
                405                 410                 415     


Val Glu Phe Ala Lys Arg Ile Pro Gly Phe Arg Asp Leu Ser Gln His 
            420                 425                 430         


Asp Gln Val Asn Leu Leu Lys Ala Gly Thr Phe Glu Val Leu Met Val 
        435                 440                 445             


Arg Phe Ala Ser Leu Phe Asp Ala Lys Glu Arg Thr Val Thr Phe Leu 
    450                 455                 460                 


Ser Gly Lys Lys Tyr Ser Val Asp Asp Leu His Ser Met Gly Ala Gly 
465                 470                 475                 480 


Asp Leu Leu Asn Ser Met Phe Glu Phe Ser Glu Lys Leu Asn Ala Leu 
                485                 490                 495     


Gln Leu Ser Asp Glu Glu Met Ser Leu Phe Thr Ala Val Val Leu Val 
            500                 505                 510         


Ser Ala Asp Arg Ser Gly Ile Glu Asn Val Asn Ser Val Glu Ala Leu 
        515                 520                 525             


Gln Glu Thr Leu Ile Arg Ala Leu Arg Thr Leu Ile Met Lys Asn His 
    530                 535                 540                 


Pro Asn Glu Ala Ser Ile Phe Thr Lys Leu Leu Leu Lys Leu Pro Asp 
545                 550                 555                 560 


Leu Arg Ser Leu Asn Asn Met His Ser Glu Glu Leu Leu Ala Phe Lys 
                565                 570                 575     


Val His 
        


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer A for detection of E4bp4 wildtype allele

<400>  9
ctctgagctt ggctgatgtg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for the detection of E4bp4

<400>  10
gcttcaagtc tccaccaagc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for the detection of the E4bp4 null allele

<400>  11
ccatgctcct gtcttgatga                                                   20


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  side chain on SUMO modified peptide

<400>  12

Gly Gly Thr Gln Gln Gln Phe Val 
1               5               


<210>  13
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  13

Met Gln Leu Arg Lys Met Gln Thr Ile Lys Lys Glu Pro Ala Pro Leu 
1               5                   10                  15      


Asp Pro Thr Ser 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Rattus rattus

<400>  14

Met Gln Leu Arg Lys Met Gln Ala Ile Lys Lys Glu Pro Ala Ser Leu 
1               5                   10                  15      


Asp Pro Thr Gly 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gln Leu Arg Lys Met Gln Thr Val Lys Lys Glu Gln Ala Ser Leu 
1               5                   10                  15      


Asp Ala Ser Ser 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Gallus gallus

<400>  16

Met Gln Leu Arg Lys Met Gln Thr Leu Lys Lys Glu His Gly Ser Val 
1               5                   10                  15      


Asp Thr Ser Ser 
            20  


<210>  17
<211>  15
<212>  PRT
<213>  Xenopus laevis

<400>  17

Met Pro Thr Ile Lys Lys Glu Gln Glu Cys Ala Asp Ser Arg Met 
1               5                   10                  15  


<210>  18
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  18

Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn Ala Thr Leu Lys 
1               5                   10                  15      


Ala Glu Leu Leu 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Rattus rattus

<400>  19

Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn Ala Thr Leu Lys 
1               5                   10                  15      


Ala Glu Leu Leu 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  20

Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn Ala Thr Leu Lys 
1               5                   10                  15      


Ala Glu Leu Leu 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Gallus gallus

<400>  21

Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn Ala Thr Leu Lys 
1               5                   10                  15      


Ala Glu Leu Leu 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Xenopus laevis

<400>  22

Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn Ala Ser Leu Lys 
1               5                   10                  15      


Thr Glu Leu Leu 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  23

Pro Glu Asn Lys Phe Pro Val Ile Lys Gln Glu Pro Val Glu Leu Glu 
1               5                   10                  15      


Ser Phe Ala Arg 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Rattus rattus

<400>  24

Pro Glu Asn Lys Phe Pro Val Ile Lys Gln Glu Pro Val Glu Leu Glu 
1               5                   10                  15      


Ser Phe Ala Arg 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  25

Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Met Glu Leu Glu 
1               5                   10                  15      


Ser Tyr Thr Arg 
            20  


<210>  26
<211>  17
<212>  PRT
<213>  Gallus gallus

<400>  26

Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Ile Glu Leu Glu 
1               5                   10                  15      


Arg 
    


<210>  27
<211>  20
<212>  PRT
<213>  Xenopus laevis

<400>  27

Thr Asp Ile Lys Ser Gln Arg Ile Lys Gln Glu Gln Met Glu Ala Gly 
1               5                   10                  15      


Asn Phe Ser Arg 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  28

Arg Ile Lys Ala Lys Ala Met Gln Val Lys Val Glu Ala Leu Asp Ser 
1               5                   10                  15      


Glu Phe Glu Gly 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Rattus rattus

<400>  29

Arg Ile Lys Ala Lys Ala Met Gln Val Lys Val Glu Ala Leu Asp Ser 
1               5                   10                  15      


Glu Phe Glu Gly 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Ile Lys Ala Lys Ala Met Gln Ile Lys Val Glu Ala Phe Asp Asn 
1               5                   10                  15      


Glu Phe Glu Ala 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Gallus gallus

<400>  31

Arg Ile Lys Ala Lys Ala Met Gln Val Lys Val Glu Ala Met Asp Asn 
1               5                   10                  15      


Asp Tyr Asp Ala 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Xenopus laevis

<400>  32

Arg Ile Lys Ala Lys Ala Met Gln Ile Lys Val Glu Ser Leu Glu Ser 
1               5                   10                  15      


Glu Leu Asn Ser 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  33

Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His His 
1               5                   10                  15      


Lys Glu Leu Ser 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Rattus rattus

<400>  34

Val Thr Asn Ile Gln Asp Trp Ser Leu Arg Ser Glu His Trp His His 
1               5                   10                  15      


Lys Glu Leu Gly 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  35

Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His Gln 
1               5                   10                  15      


Lys Glu Leu Ser 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Gallus gallus

<400>  36

Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Pro Glu Leu Trp His Gln 
1               5                   10                  15      


Lys Glu Leu Asn 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Xenopus laevis

<400>  37

Val Thr Asn Ile Gln Asp Trp Pro Leu Lys Pro Gly Gln Trp His His 
1               5                   10                  15      


Arg Glu Leu Glu 
            20  


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  38
ctatattttt gccttgacag ctaaagg                                           27


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  39
gaagtacgaa gcatgcttgc                                                   20


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  40
cacatctgtg agctattttt gg                                                22


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  41
gactgactaa actaacattc ccac                                              24


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  42
ctcagaaact ggcctcaagc                                                   20


<210>  43
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  43
cacttgcagt caggcgttc                                                    19


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  44
cacgccatct taaagagctc                                                   20


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  45
gtaaccaact gcactcttct cc                                                22


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  46
caccaagaat tcccaggag                                                    19


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  47
gagtgcagtc acgtgctgac                                                   20


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  48
ctcagactct ctcggtaagt gtc                                               23


<210>  49
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplification of putative E4bp4-binding 
       regions in Notch1 locus

<400>  49
cgtgtggagc tactctggc                                                    19


<210>  50
<211>  426
<212>  DNA
<213>  Homo sapiens

<400>  50
atgtcaaaca tgagatgtgt ggactgtggc acttgcctgg gtcacacacg gaggcatcct       60

acccttttct ggggaaagac actgcctggg ctgaccccgg tggcggcccc agcacctcag      120

cctgcacagt gtcccccagg ttccgaagaa gatgctccag caacacagcc tgggccccag      180

ctcgcgggac ccgacccccc gtgggctccc gtgttttgta ggagacttgc cagagccggg      240

cacattgagc tgtgcaacgc cgtgggctgc gtcctttggt cctgtccccg cagccctggc      300

agggggcatg cggtcgggca ggggctggag ggaggcgggg gctgcccttg ggccacccct      360

cctagtttgg gaggagcaga tttttgcaat accaagtata gcctatggca gaaaaaatgt      420

ctttaa                                                                 426


<210>  51
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ser Asn Met Arg Cys Val Asp Cys Gly Thr Cys Leu Gly His Thr 
1               5                   10                  15      


Arg Arg His Pro Thr Leu Phe Trp Gly Lys Thr Leu Pro Gly Leu Thr 
            20                  25                  30          


Pro Val Ala Ala Pro Ala Pro Gln Pro Ala Gln Cys Pro Pro Gly Ser 
        35                  40                  45              


Glu Glu Asp Ala Pro Ala Thr Gln Pro Gly Pro Gln Leu Ala Gly Pro 
    50                  55                  60                  


Asp Pro Pro Trp Ala Pro Val Phe Cys Arg Arg Leu Ala Arg Ala Gly 
65                  70                  75                  80  


His Ile Glu Leu Cys Asn Ala Val Gly Cys Val Leu Trp Ser Cys Pro 
                85                  90                  95      


Arg Ser Pro Gly Arg Gly His Ala Val Gly Gln Gly Leu Glu Gly Gly 
            100                 105                 110         


Gly Gly Cys Pro Trp Ala Thr Pro Pro Ser Leu Gly Gly Ala Asp Phe 
        115                 120                 125             


Cys Asn Thr Lys Tyr Ser Leu Trp Gln Lys Lys Cys Leu 
    130                 135                 140     


