                         SEQUENCE LISTING

<110>  SCHEPENS EYE RESEARCH INSTITUTE (SERI)
 
<120>  BLOOD BIOMARKERS AND DIAGNOSTIC METHODS

<130>  36770-553001WO

<150>  62/477,274
<151>  2017-03-27

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  2
<211>  549
<212>  DNA
<213>  Homo sapiens

<400>  2
cacagccacc gcgacttcca gccggtgctc cacctggttg cgctcaacag ccccctgtca       60

ggcggcatgc ggggcatccg cggggccgac ttccagtgct tccagcaggc gcgggccgtg      120

gggctggcgg gcaccttccg cgccttcctg tcctcgcgcc tgcaggacct gtacagcatc      180

gtgcgccgtg ccgaccgcgc agccgtgccc atcgtcaacc tcaaggacga gctgctgttt      240

cccagctggg aggctctgtt ctcaggctct gagggtccgc tgaagcccgg ggcacgcatc      300

ttctcctttg acggcaagga cgtcctgagg caccccacct ggccccagaa gagcgtgtgg      360

catggctcgg accccaacgg gcgcaggctg accgagagct actgtgagac gtggcggacg      420

gaggctccct cggccacggg ccaggcctcc tcgctgctgg ggggcaggct cctggggcag      480

agtgccgcga gctgccatca cgcctacatc gtgctctgca ttgagaacag cttcatgact      540

gcctccaag                                                              549


<210>  3
<211>  2321
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Ala 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210>  4
<211>  8091
<212>  DNA
<213>  Homo sapiens

<400>  4
acgcggcgcg gaggctggcc cgggacgcgc ccggagccca gggaaggagg gaggagggga       60

gggtcgcggc cggccgccat ggggccgggg gcccgtggcc gccgccgccg ccgtcgcccg      120

atgtcgccgc caccgccacc gccacccgtg cgggcgctgc ccctgctgct gctgctagcg      180

gggccggggg ctgcagcccc cccttgcctg gacggaagcc cgtgtgcaaa tggaggtcgt      240

tgcacccagc tgccctcccg ggaggctgcc tgcctgtgcc cgcctggctg ggtgggtgag      300

cggtgtcagc tggaggaccc ctgtcactca ggcccctgtg ctggccgtgg tgtctgccag      360

agttcagtgg tggctggcac cgcccgattc tcatgccggt gcccccgtgg cttccgaggc      420

cctgactgct ccctgccaga tccctgcctc agcagccctt gtgcccacgg tgcccgctgc      480

tcagtggggc ccgatggacg cttcctctgc tcctgcccac ctggctacca gggccgcagc      540

tgccgaagcg acgtggatga gtgccgggtg ggtgagccct gccgccatgg tggcacctgc      600

ctcaacacac ctggctcctt ccgctgccag tgtccagctg gctacacagg gccactatgt      660

gagaaccccg cggtgccctg tgcgccctca ccatgccgta acgggggcac ctgcaggcag      720

agtggcgacc tcacttacga ctgtgcctgt cttcctgggt ttgagggtca gaattgtgaa      780

gtgaacgtgg acgactgtcc aggacaccga tgtctcaatg gggggacatg cgtggatggc      840

gtcaacacct ataactgcca gtgccctcct gagtggacag gccagttctg cacggaggac      900

gtggatgagt gtcagctgca gcccaacgcc tgccacaatg ggggtacctg cttcaacacg      960

ctgggtggcc acagctgcgt gtgtgtcaat ggctggacag gtgagagctg cagtcagaat     1020

atcgatgact gtgccacagc cgtgtgcttc catggggcca cctgccatga ccgcgtggct     1080

tctttctact gtgcctgccc catgggcaag actggcctcc tgtgtcacct ggatgacgcc     1140

tgtgtcagca acccctgcca cgaggatgct atctgtgaca caaatccggt gaacggccgg     1200

gccatttgca cctgtcctcc cggcttcacg ggtggggcat gtgaccagga tgtggacgag     1260

tgctctatcg gcgccaaccc ctgcgagcac ttgggcaggt gcgtgaacac gcagggctcc     1320

ttcctgtgcc agtgcggtcg tggctacact ggacctcgct gtgagaccga tgtcaacgag     1380

tgtctgtcgg ggccctgccg aaaccaggcc acgtgcctcg accgcatagg ccagttcacc     1440

tgtatctgta tggcaggctt cacaggaacc tattgcgagg tggacattga cgagtgtcag     1500

agtagcccct gtgtcaacgg tggggtctgc aaggaccgag tcaatggctt cagctgcacc     1560

tgcccctcgg gcttcagcgg ctccacgtgt cagctggacg tggacgaatg cgccagcacg     1620

ccctgcagga atggcgccaa atgcgtggac cagcccgatg gctacgagtg ccgctgtgcc     1680

gagggctttg agggcacgct gtgtgatcgc aacgtggacg actgctcccc tgacccatgc     1740

caccatggtc gctgcgtgga tggcatcgcc agcttctcat gtgcctgtgc tcctggctac     1800

acgggcacac gctgcgagag ccaggtggac gaatgccgca gccagccctg ccgccatggc     1860

ggcaaatgcc tagacctggt ggacaagtac ctctgccgct gcccttctgg gaccacaggt     1920

gtgaactgcg aagtgaacat tgacgactgt gccagcaacc cctgcacctt tggagtctgc     1980

cgtgatggca tcaaccgcta cgactgtgtc tgccaacctg gcttcacagg gcccctttgt     2040

aacgtggaga tcaatgagtg tgcttccagc ccatgcggcg agggaggttc ctgtgtggat     2100

ggggaaaatg gcttccgctg cctctgcccg cctggctcct tgcccccact ctgcctcccc     2160

ccgagccatc cctgtgccca tgagccctgc agtcacggca tctgctatga tgcacctggc     2220

gggttccgct gtgtgtgtga gcctggctgg agtggccccc gctgcagcca gagcctggcc     2280

cgagacgcct gtgagtccca gccgtgcagg gccggtggga catgcagcag cgatggaatg     2340

ggtttccact gcacctgccc gcctggtgtc cagggacgtc agtgtgaact cctctccccc     2400

tgcaccccga acccctgtga gcatgggggc cgctgcgagt ctgcccctgg ccagctgcct     2460

gtctgctcct gcccccaggg ctggcaaggc ccacgatgcc agcaggatgt ggacgagtgt     2520

gctggccccg caccctgtgg ccctcatggt atctgcacca acctggcagg gagtttcagc     2580

tgcacctgcc atggagggta cactggccct tcctgtgatc aggacatcaa tgactgtgac     2640

cccaacccat gcctgaacgg tggctcgtgc caagacggcg tgggctcctt ttcctgctcc     2700

tgcctccctg gtttcgccgg cccacgatgc gcccgcgatg tggatgagtg cctgagcaac     2760

ccctgcggcc cgggcacctg taccgaccac gtggcctcct tcacctgcac ctgcccgccg     2820

ggctacggag gcttccactg cgaacaggac ctgcccgact gcagccccag ctcctgcttc     2880

aatggcggga cctgtgtgga cggcgtgaac tcgttcagct gcctgtgccg tcccggctac     2940

acaggagccc actgccaaca tgaggcagac ccctgcctct cgcggccctg cctacacggg     3000

ggcgtctgca gcgccgccca ccctggcttc cgctgcacct gcctcgagag cttcacgggc     3060

ccgcagtgcc agacgctggt ggattggtgc agccgccagc cttgtcaaaa cgggggtcgc     3120

tgcgtccaga ctggggccta ttgcctttgt ccccctggat ggagcggacg cctctgtgac     3180

atccgaagct tgccctgcag ggaggccgca gcccagatcg gggtgcggct ggagcagctg     3240

tgtcaggcgg gtgggcagtg tgtggatgaa gacagctccc actactgcgt gtgcccagag     3300

ggccgtactg gtagccactg tgagcaggag gtggacccct gcttggccca gccctgccag     3360

catgggggga cctgccgtgg ctatatgggg ggctacatgt gtgagtgtct tcctggctac     3420

aatggtgata actgtgagga cgacgtggac gagtgtgcct cccagccctg ccagcacggg     3480

ggttcatgca ttgacctcgt ggcccgctat ctctgctcct gtcccccagg aacgctgggg     3540

gtgctctgcg agattaatga ggatgactgc ggcccaggcc caccgctgga ctcagggccc     3600

cggtgcctac acaatggcac ctgcgtggac ctggtgggtg gtttccgctg cacctgtccc     3660

ccaggataca ctggtttgcg ctgcgaggca gacatcaatg agtgtcgctc aggtgcctgc     3720

cacgcggcac acacccggga ctgcctgcag gacccaggcg gaggtttccg ttgcctttgt     3780

catgctggct tctcaggtcc tcgctgtcag actgtcctgt ctccctgcga gtcccagcca     3840

tgccagcatg gaggccagtg ccgtcctagc ccgggtcctg ggggtgggct gaccttcacc     3900

tgtcactgtg cccagccgtt ctggggtccg cgttgcgagc gggtggcgcg ctcctgccgg     3960

gagctgcagt gcccggtggg cgtcccatgc cagcagacgc cccgcgggcc gcgctgcgcc     4020

tgccccccag ggttgtcggg accctcctgc cgcagcttcc cggggtcgcc gccgggggcc     4080

agcaacgcca gctgcgcggc cgccccctgt ctccacgggg gctcctgccg ccccgcgccg     4140

ctcgcgccct tcttccgctg cgcttgcgcg cagggctgga ccgggccgcg ctgcgaggcg     4200

cccgccgcgg cacccgaggt ctcggaggag ccgcggtgcc cgcgcgccgc ctgccaggcc     4260

aagcgcgggg accagcgctg cgaccgcgag tgcaacagcc caggctgcgg ctgggacggc     4320

ggcgactgct cgctgagcgt gggcgacccc tggcggcaat gcgaggcgct gcagtgctgg     4380

cgcctcttca acaacagccg ctgcgacccc gcctgcagct cgcccgcctg cctctacgac     4440

aacttcgact gccacgccgg tggccgcgag cgcacttgca acccggtgta cgagaagtac     4500

tgcgccgacc actttgccga cggccgctgc gaccagggct gcaacacgga ggagtgcggc     4560

tgggatgggc tggattgtgc cagcgaggtg ccggccctgc tggcccgcgg cgtgctggtg     4620

ctcacagtgc tgctgccgcc ggaggagcta ctgcgttcca gcgccgactt tctgcagcgg     4680

ctcagcgcca tcctgcgcac ctcgctgcgc ttccgcctgg acgcgcacgg ccaggccatg     4740

gtcttccctt accaccggcc tagtcctggc tccgaacccc gggcccgtcg ggagctggcc     4800

cccgaggtga tcggctcggt agtaatgctg gagattgaca accggctctg cctgcagtcg     4860

cctgagaatg atcactgctt ccccgatgcc cagagcgccg ctgactacct gggagcgttg     4920

tcagcggtgg agcgcctgga cttcccgtac ccactgcggg acgtgcgggg ggagccgctg     4980

gagcctccag aacccagcgt cccgctgctg ccactgctag tggcgggcgc tgtcttgctg     5040

ctggtcattc tcgtcctggg tgtcatggtg gcccggcgca agcgcgagca cagcaccctc     5100

tggttccctg agggcttctc actgcacaag gacgtggcct ctggtcacaa gggccggcgg     5160

gaacccgtgg gccaggacgc gctgggcatg aagaacatgg ccaagggtga gagcctgatg     5220

ggggaggtgg ccacagactg gatggacaca gagtgcccag aggccaagcg gctaaaggta     5280

gaggagccag gcatgggggc tgaggaggct gtggattgcc gtcagtggac tcaacaccat     5340

ctggttgctg ctgacatccg cgtggcacca gccatggcac tgacaccacc acagggcgac     5400

gcagatgctg atggcatgga tgtcaatgtg cgtggcccag atggcttcac cccgctaatg     5460

ctggcttcct tctgtggggg ggctctggag ccaatgccaa ctgaagagga tgaggcagat     5520

gacacatcag ctagcatcat ctccgacctg atctgccagg gggctcagct tggggcacgg     5580

actgaccgta ctggcgagac tgctttgcac ctggctgccc gttatgcccg tgctgatgca     5640

gccaagcggc tgctggatgc tggggcagac accaatgccc aggaccactc aggccgcact     5700

cccctgcaca cagctgtcac agccgatgcc cagggtgtct tccagattct catccgaaac     5760

cgctctacag acttggatgc ccgcatggca gatggctcaa cggcactgat cctggcggcc     5820

cgcctggcag tagagggcat ggtggaagag ctcatcgcca gccatgctga tgtcaatgct     5880

gtggatgagc ttgggaaatc agccttacac tgggctgcgg ctgtgaacaa cgtggaagcc     5940

actttggccc tgctcaaaaa tggagccaat aaggacatgc aggatagcaa ggaggagacc     6000

cccctattcc tggccgcccg cgagggcagc tatgaggctg ccaagctgct gttggaccac     6060

tttgccaacc gtgagatcac cgaccacctg gacaggctgc cgcgggacgt agcccaggag     6120

agactgcacc aggacatcgt gcgcttgctg gatcaaccca gtgggccccg cagccccccc     6180

ggtccccacg gcctggggcc tctgctctgt cctccagggg ccttcctccc tggcctcaaa     6240

gcggcacagt cggggtccaa gaagagcagg aggccccccg ggaaggcggg gctggggccg     6300

caggggcccc gggggcgggg caagaagctg acgctggcct gcccgggccc cctggctgac     6360

agctcggtca cgctgtcgcc cgtggactcg ctggactccc cgcggccttt cggtgggccc     6420

cctgcttccc ctggtggctt cccccttgag gggccctatg cagctgccac tgccactgca     6480

gtgtctctgg cacagcttgg tggcccaggc cgggcaggtc tagggcgcca gccccctgga     6540

ggatgtgtac tcagcctggg cctgctgaac cctgtggctg tgcccctcga ttgggcccgg     6600

ctgcccccac ctgcccctcc aggcccctcg ttcctgctgc cactggcgcc gggaccccag     6660

ctgctcaacc cagggacccc cgtctccccg caggagcggc ccccgcctta cctggcagtc     6720

ccaggacatg gcgaggagta cccggtggct ggggcacaca gcagcccccc aaaggcccgc     6780

ttcctgcggg ttcccagtga gcacccttac ctgaccccat cccccgaatc ccctgagcac     6840

tgggccagcc cctcacctcc ctccctctca gactggtccg aatccacgcc tagcccagcc     6900

actgccactg gggccatggc caccaccact ggggcactgc ctgcccagcc acttcccttg     6960

tctgttccca gctcccttgc tcaggcccag acccagctgg ggccccagcc ggaagttacc     7020

cccaagaggc aagtgttggc ctgagacgct cgtcagttct tagatcttgg gggcctaaag     7080

agacccccgt cctgcctcct ttctttctct gtctcttcct tccttttagt ctttttcatc     7140

ctcttctctt tccaccaacc ctcctgcatc cttgccttgc agcgtgaccg agataggtca     7200

tcagcccagg gcttcagtct tcctttattt ataatgggtg ggggctacca cccaccctct     7260

cagtcttgtg aagagtctgg gacctccttc ttccccactt ctctcttccc tcattccttt     7320

ctctctcctt ctggcctctc atttccttac actctgacat gaatgaatta ttattatttt     7380

tctttttctt ttttttttta cattttgtat agaaacaaat tcatttaaac aaacttatta     7440

ttattatttt ttacaaaata tatatatgga gatgctccct ccccctgtga accccccagt     7500

gcccccgtgg ggctgagtct gtgggcccat tcggccaagc tggattctgt gtacctagta     7560

cacaggcatg actgggatcc cgtgtaccga gtacacgacc caggtatgta ccaagtaggc     7620

acccttgggc gcacccactg gggccagggg tcgggggagt gttgggagcc tcctccccac     7680

cccacctccc tcacttcact gcattccaga ttggacatgt tccatagcct tgctggggaa     7740

gggcccactg ccaactccct ctgccccagc cccacccttg gccatctccc tttgggaact     7800

agggggctgc tggtgggaaa tgggagccag ggcagatgta tgcattcctt tatgtccctg     7860

taaatgtggg actacaagaa gaggagctgc ctgagtggta ctttctcttc ctggtaatcc     7920

tctggcccag ccttatggca gaatagaggt atttttaggc tatttttgta atatggcttc     7980

tggtcaaaat ccctgtgtag ctgaattccc aagccctgca ttgtacagcc ccccactccc     8040

ctcaccacct aataaaggaa tagttaacac tcaaaaaaaa aaaaaaaaaa a              8091


<210>  5
<211>  1532
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Pro Pro Cys Leu Asp Gly Ser Pro Cys Ala Asn Gly Gly Arg Cys 
1               5                   10                  15      


Thr Gln Leu Pro Ser Arg Glu Ala Ala Cys Leu Cys Pro Pro Gly Trp 
            20                  25                  30          


Val Gly Glu Arg Cys Gln Leu Glu Asp Pro Cys His Ser Gly Pro Cys 
        35                  40                  45              


Ala Gly Arg Gly Val Cys Gln Ser Ser Val Val Ala Gly Thr Ala Arg 
    50                  55                  60                  


Phe Ser Cys Arg Cys Pro Arg Gly Phe Arg Gly Pro Asp Cys Ser Leu 
65                  70                  75                  80  


Pro Asp Pro Cys Leu Ser Ser Pro Cys Ala His Gly Ala Arg Cys Ser 
                85                  90                  95      


Val Gly Pro Asp Gly Arg Phe Leu Cys Ser Cys Pro Pro Gly Tyr Gln 
            100                 105                 110         


Gly Arg Ser Cys Arg Ser Asp Val Asp Glu Cys Arg Val Gly Glu Pro 
        115                 120                 125             


Cys Arg His Gly Gly Thr Cys Leu Asn Thr Pro Gly Ser Phe Arg Cys 
    130                 135                 140                 


Gln Cys Pro Ala Gly Tyr Thr Gly Pro Leu Cys Glu Asn Pro Ala Val 
145                 150                 155                 160 


Pro Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Thr Cys Arg Gln Ser 
                165                 170                 175     


Gly Asp Leu Thr Tyr Asp Cys Ala Cys Leu Pro Gly Phe Glu Gly Gln 
            180                 185                 190         


Asn Cys Glu Val Asn Val Asp Asp Cys Pro Gly His Arg Cys Leu Asn 
        195                 200                 205             


Gly Gly Thr Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Gln Cys Pro 
    210                 215                 220                 


Pro Glu Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Gln 
225                 230                 235                 240 


Leu Gln Pro Asn Ala Cys His Asn Gly Gly Thr Cys Phe Asn Thr Leu 
                245                 250                 255     


Gly Gly His Ser Cys Val Cys Val Asn Gly Trp Thr Gly Glu Ser Cys 
            260                 265                 270         


Ser Gln Asn Ile Asp Asp Cys Ala Thr Ala Val Cys Phe His Gly Ala 
        275                 280                 285             


Thr Cys His Asp Arg Val Ala Ser Phe Tyr Cys Ala Cys Pro Met Gly 
    290                 295                 300                 


Lys Thr Gly Leu Leu Cys His Leu Asp Asp Ala Cys Val Ser Asn Pro 
305                 310                 315                 320 


Cys His Glu Asp Ala Ile Cys Asp Thr Asn Pro Val Asn Gly Arg Ala 
                325                 330                 335     


Ile Cys Thr Cys Pro Pro Gly Phe Thr Gly Gly Ala Cys Asp Gln Asp 
            340                 345                 350         


Val Asp Glu Cys Ser Ile Gly Ala Asn Pro Cys Glu His Leu Gly Arg 
        355                 360                 365             


Cys Val Asn Thr Gln Gly Ser Phe Leu Cys Gln Cys Gly Arg Gly Tyr 
    370                 375                 380                 


Thr Gly Pro Arg Cys Glu Thr Asp Val Asn Glu Cys Leu Ser Gly Pro 
385                 390                 395                 400 


Cys Arg Asn Gln Ala Thr Cys Leu Asp Arg Ile Gly Gln Phe Thr Cys 
                405                 410                 415     


Ile Cys Met Ala Gly Phe Thr Gly Thr Tyr Cys Glu Val Asp Ile Asp 
            420                 425                 430         


Glu Cys Gln Ser Ser Pro Cys Val Asn Gly Gly Val Cys Lys Asp Arg 
        435                 440                 445             


Val Asn Gly Phe Ser Cys Thr Cys Pro Ser Gly Phe Ser Gly Ser Thr 
    450                 455                 460                 


Cys Gln Leu Asp Val Asp Glu Cys Ala Ser Thr Pro Cys Arg Asn Gly 
465                 470                 475                 480 


Ala Lys Cys Val Asp Gln Pro Asp Gly Tyr Glu Cys Arg Cys Ala Glu 
                485                 490                 495     


Gly Phe Glu Gly Thr Leu Cys Asp Arg Asn Val Asp Asp Cys Ser Pro 
            500                 505                 510         


Asp Pro Cys His His Gly Arg Cys Val Asp Gly Ile Ala Ser Phe Ser 
        515                 520                 525             


Cys Ala Cys Ala Pro Gly Tyr Thr Gly Thr Arg Cys Glu Ser Gln Val 
    530                 535                 540                 


Asp Glu Cys Arg Ser Gln Pro Cys Arg His Gly Gly Lys Cys Leu Asp 
545                 550                 555                 560 


Leu Val Asp Lys Tyr Leu Cys Arg Cys Pro Ser Gly Thr Thr Gly Val 
                565                 570                 575     


Asn Cys Glu Val Asn Ile Asp Asp Cys Ala Ser Asn Pro Cys Thr Phe 
            580                 585                 590         


Gly Val Cys Arg Asp Gly Ile Asn Arg Tyr Asp Cys Val Cys Gln Pro 
        595                 600                 605             


Gly Phe Thr Gly Pro Leu Cys Asn Val Glu Ile Asn Glu Cys Ala Ser 
    610                 615                 620                 


Ser Pro Cys Gly Glu Gly Gly Ser Cys Val Asp Gly Glu Asn Gly Phe 
625                 630                 635                 640 


Arg Cys Leu Cys Pro Pro Gly Ser Leu Pro Pro Leu Cys Leu Pro Pro 
                645                 650                 655     


Ser His Pro Cys Ala His Glu Pro Cys Ser His Gly Ile Cys Tyr Asp 
            660                 665                 670         


Ala Pro Gly Gly Phe Arg Cys Val Cys Glu Pro Gly Trp Ser Gly Pro 
        675                 680                 685             


Arg Cys Ser Gln Ser Leu Ala Arg Asp Ala Cys Glu Ser Gln Pro Cys 
    690                 695                 700                 


Arg Ala Gly Gly Thr Cys Ser Ser Asp Gly Met Gly Phe His Cys Thr 
705                 710                 715                 720 


Cys Pro Pro Gly Val Gln Gly Arg Gln Cys Glu Leu Leu Ser Pro Cys 
                725                 730                 735     


Thr Pro Asn Pro Cys Glu His Gly Gly Arg Cys Glu Ser Ala Pro Gly 
            740                 745                 750         


Gln Leu Pro Val Cys Ser Cys Pro Gln Gly Trp Gln Gly Pro Arg Cys 
        755                 760                 765             


Gln Gln Asp Val Asp Glu Cys Ala Gly Pro Ala Pro Cys Gly Pro His 
    770                 775                 780                 


Gly Ile Cys Thr Asn Leu Ala Gly Ser Phe Ser Cys Thr Cys His Gly 
785                 790                 795                 800 


Gly Tyr Thr Gly Pro Ser Cys Asp Gln Asp Ile Asn Asp Cys Asp Pro 
                805                 810                 815     


Asn Pro Cys Leu Asn Gly Gly Ser Cys Gln Asp Gly Val Gly Ser Phe 
            820                 825                 830         


Ser Cys Ser Cys Leu Pro Gly Phe Ala Gly Pro Arg Cys Ala Arg Asp 
        835                 840                 845             


Val Asp Glu Cys Leu Ser Asn Pro Cys Gly Pro Gly Thr Cys Thr Asp 
    850                 855                 860                 


His Val Ala Ser Phe Thr Cys Thr Cys Pro Pro Gly Tyr Gly Gly Phe 
865                 870                 875                 880 


His Cys Glu Gln Asp Leu Pro Asp Cys Ser Pro Ser Ser Cys Phe Asn 
                885                 890                 895     


Gly Gly Thr Cys Val Asp Gly Val Asn Ser Phe Ser Cys Leu Cys Arg 
            900                 905                 910         


Pro Gly Tyr Thr Gly Ala His Cys Gln His Glu Ala Asp Pro Cys Leu 
        915                 920                 925             


Ser Arg Pro Cys Leu His Gly Gly Val Cys Ser Ala Ala His Pro Gly 
    930                 935                 940                 


Phe Arg Cys Thr Cys Leu Glu Ser Phe Thr Gly Pro Gln Cys Gln Thr 
945                 950                 955                 960 


Leu Val Asp Trp Cys Ser Arg Gln Pro Cys Gln Asn Gly Gly Arg Cys 
                965                 970                 975     


Val Gln Thr Gly Ala Tyr Cys Leu Cys Pro Pro Gly Trp Ser Gly Arg 
            980                 985                 990         


Leu Cys Asp Ile Arg Ser Leu Pro  Cys Arg Glu Ala Ala  Ala Gln Ile 
        995                 1000                 1005             


Gly Val  Arg Leu Glu Gln Leu  Cys Gln Ala Gly Gly  Gln Cys Val 
    1010                 1015                 1020             


Asp Glu  Asp Ser Ser His Tyr  Cys Val Cys Pro Glu  Gly Arg Thr 
    1025                 1030                 1035             


Gly Ser  His Cys Glu Gln Glu  Val Asp Pro Cys Leu  Ala Gln Pro 
    1040                 1045                 1050             


Cys Gln  His Gly Gly Thr Cys  Arg Gly Tyr Met Gly  Gly Tyr Met 
    1055                 1060                 1065             


Cys Glu  Cys Leu Pro Gly Tyr  Asn Gly Asp Asn Cys  Glu Asp Asp 
    1070                 1075                 1080             


Val Asp  Glu Cys Ala Ser Gln  Pro Cys Gln His Gly  Gly Ser Cys 
    1085                 1090                 1095             


Ile Asp  Leu Val Ala Arg Tyr  Leu Cys Ser Cys Pro  Pro Gly Thr 
    1100                 1105                 1110             


Leu Gly  Val Leu Cys Glu Ile  Asn Glu Asp Asp Cys  Gly Pro Gly 
    1115                 1120                 1125             


Pro Pro  Leu Asp Ser Gly Pro  Arg Cys Leu His Asn  Gly Thr Cys 
    1130                 1135                 1140             


Val Asp  Leu Val Gly Gly Phe  Arg Cys Thr Cys Pro  Pro Gly Tyr 
    1145                 1150                 1155             


Thr Gly  Leu Arg Cys Glu Ala  Asp Ile Asn Glu Cys  Arg Ser Gly 
    1160                 1165                 1170             


Ala Cys  His Ala Ala His Thr  Arg Asp Cys Leu Gln  Asp Pro Gly 
    1175                 1180                 1185             


Gly Gly  Phe Arg Cys Leu Cys  His Ala Gly Phe Ser  Gly Pro Arg 
    1190                 1195                 1200             


Cys Gln  Thr Val Leu Ser Pro  Cys Glu Ser Gln Pro  Cys Gln His 
    1205                 1210                 1215             


Gly Gly  Gln Cys Arg Pro Ser  Pro Gly Pro Gly Gly  Gly Leu Thr 
    1220                 1225                 1230             


Phe Thr  Cys His Cys Ala Gln  Pro Phe Trp Gly Pro  Arg Cys Glu 
    1235                 1240                 1245             


Arg Val  Ala Arg Ser Cys Arg  Glu Leu Gln Cys Pro  Val Gly Val 
    1250                 1255                 1260             


Pro Cys  Gln Gln Thr Pro Arg  Gly Pro Arg Cys Ala  Cys Pro Pro 
    1265                 1270                 1275             


Gly Leu  Ser Gly Pro Ser Cys  Arg Ser Phe Pro Gly  Ser Pro Pro 
    1280                 1285                 1290             


Gly Ala  Ser Asn Ala Ser Cys  Ala Ala Ala Pro Cys  Leu His Gly 
    1295                 1300                 1305             


Gly Ser  Cys Arg Pro Ala Pro  Leu Ala Pro Phe Phe  Arg Cys Ala 
    1310                 1315                 1320             


Cys Ala  Gln Gly Trp Thr Gly  Pro Arg Cys Glu Ala  Pro Ala Ala 
    1325                 1330                 1335             


Ala Pro  Glu Val Ser Glu Glu  Pro Arg Cys Pro Arg  Ala Ala Cys 
    1340                 1345                 1350             


Gln Ala  Lys Arg Gly Asp Gln  Arg Cys Asp Arg Glu  Cys Asn Ser 
    1355                 1360                 1365             


Pro Gly  Cys Gly Trp Asp Gly  Gly Asp Cys Ser Leu  Ser Val Gly 
    1370                 1375                 1380             


Asp Pro  Trp Arg Gln Cys Glu  Ala Leu Gln Cys Trp  Arg Leu Phe 
    1385                 1390                 1395             


Asn Asn  Ser Arg Cys Asp Pro  Ala Cys Ser Ser Pro  Ala Cys Leu 
    1400                 1405                 1410             


Tyr Asp  Asn Phe Asp Cys His  Ala Gly Gly Arg Glu  Arg Thr Cys 
    1415                 1420                 1425             


Asn Pro  Val Tyr Glu Lys Tyr  Cys Ala Asp His Phe  Ala Asp Gly 
    1430                 1435                 1440             


Arg Cys  Asp Gln Gly Cys Asn  Thr Glu Glu Cys Gly  Trp Asp Gly 
    1445                 1450                 1455             


Leu Asp  Cys Ala Ser Glu Val  Pro Ala Leu Leu Ala  Arg Gly Val 
    1460                 1465                 1470             


Leu Val  Leu Thr Val Leu Leu  Pro Pro Glu Glu Leu  Leu Arg Ser 
    1475                 1480                 1485             


Ser Ala  Asp Phe Leu Gln Arg  Leu Ser Ala Ile Leu  Arg Thr Ser 
    1490                 1495                 1500             


Leu Arg  Phe Arg Leu Asp Ala  His Gly Gln Ala Met  Val Phe Pro 
    1505                 1510                 1515             


Tyr His  Arg Pro Ser Pro Gly  Ser Glu Pro Arg Ala  Arg Arg 
    1520                 1525                 1530         


<210>  6
<211>  1533
<212>  PRT
<213>  Mus musculus

<400>  6

Ala Pro Pro Cys Leu Asp Gly Ser Pro Cys Ala Asn Gly Gly Arg Cys 
1               5                   10                  15      


Thr His Gln Gln Pro Ser Leu Glu Ala Ala Cys Leu Cys Leu Pro Gly 
            20                  25                  30          


Trp Val Gly Glu Arg Cys Gln Leu Glu Asp Pro Cys His Ser Gly Pro 
        35                  40                  45              


Cys Ala Gly Arg Gly Val Cys Gln Ser Ser Val Val Ala Gly Thr Ala 
    50                  55                  60                  


Arg Phe Ser Cys Arg Cys Leu Arg Gly Phe Gln Gly Pro Asp Cys Ser 
65                  70                  75                  80  


Gln Pro Asp Pro Cys Val Ser Arg Pro Cys Val His Gly Ala Pro Cys 
                85                  90                  95      


Ser Val Gly Pro Asp Gly Arg Phe Ala Cys Ala Cys Pro Pro Gly Tyr 
            100                 105                 110         


Gln Gly Gln Ser Cys Gln Ser Asp Ile Asp Glu Cys Arg Ser Gly Thr 
        115                 120                 125             


Thr Cys Arg His Gly Gly Thr Cys Leu Asn Thr Pro Gly Ser Phe Arg 
    130                 135                 140                 


Cys Gln Cys Pro Leu Gly Tyr Thr Gly Leu Leu Cys Glu Asn Pro Val 
145                 150                 155                 160 


Val Pro Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Thr Cys Arg Gln 
                165                 170                 175     


Ser Ser Asp Val Thr Tyr Asp Cys Ala Cys Leu Pro Gly Phe Glu Gly 
            180                 185                 190         


Gln Asn Cys Glu Val Asn Val Asp Asp Cys Pro Gly His Arg Cys Leu 
        195                 200                 205             


Asn Gly Gly Thr Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Gln Cys 
    210                 215                 220                 


Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys 
225                 230                 235                 240 


Gln Leu Gln Pro Asn Ala Cys His Asn Gly Gly Thr Cys Phe Asn Leu 
                245                 250                 255     


Leu Gly Gly His Ser Cys Val Cys Val Asn Gly Trp Thr Gly Glu Ser 
            260                 265                 270         


Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr Ala Val Cys Phe His Gly 
        275                 280                 285             


Ala Thr Cys His Asp Arg Val Ala Ser Phe Tyr Cys Ala Cys Pro Met 
    290                 295                 300                 


Gly Lys Thr Gly Leu Leu Cys His Leu Asp Asp Ala Cys Val Ser Asn 
305                 310                 315                 320 


Pro Cys His Glu Asp Ala Ile Cys Asp Thr Asn Pro Val Ser Gly Arg 
                325                 330                 335     


Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr Gly Gly Ala Cys Asp Gln 
            340                 345                 350         


Asp Val Asp Glu Cys Ser Ile Gly Ala Asn Pro Cys Glu His Leu Gly 
        355                 360                 365             


Arg Cys Val Asn Thr Gln Gly Ser Phe Leu Cys Gln Cys Gly Arg Gly 
    370                 375                 380                 


Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val Asn Glu Cys Leu Ser Gly 
385                 390                 395                 400 


Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp Arg Ile Gly Gln Phe Thr 
                405                 410                 415     


Cys Ile Cys Met Ala Gly Phe Thr Gly Thr Tyr Cys Glu Val Asp Ile 
            420                 425                 430         


Asp Glu Cys Gln Ser Ser Pro Cys Val Asn Gly Gly Val Cys Lys Asp 
        435                 440                 445             


Arg Val Asn Gly Phe Ser Cys Thr Cys Pro Ser Gly Phe Ser Gly Ser 
    450                 455                 460                 


Met Cys Gln Leu Asp Val Asp Glu Cys Ala Ser Thr Pro Cys Arg Asn 
465                 470                 475                 480 


Gly Ala Lys Cys Val Asp Gln Pro Asp Gly Tyr Glu Cys Arg Cys Ala 
                485                 490                 495     


Glu Gly Phe Glu Gly Thr Leu Cys Glu Arg Asn Val Asp Asp Cys Ser 
            500                 505                 510         


Pro Asp Pro Cys His His Gly Arg Cys Val Asp Gly Ile Ala Ser Phe 
        515                 520                 525             


Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly Ile Arg Cys Glu Ser Gln 
    530                 535                 540                 


Val Asp Glu Cys Arg Ser Gln Pro Cys Arg Tyr Gly Gly Lys Cys Leu 
545                 550                 555                 560 


Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys Pro Pro Gly Thr Thr Gly 
                565                 570                 575     


Val Asn Cys Glu Val Asn Ile Asp Asp Cys Ala Ser Asn Pro Cys Thr 
            580                 585                 590         


Phe Gly Val Cys Arg Asp Gly Ile Asn Arg Tyr Asp Cys Val Cys Gln 
        595                 600                 605             


Pro Gly Phe Thr Gly Pro Leu Cys Asn Val Glu Ile Asn Glu Cys Ala 
    610                 615                 620                 


Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys Val Asp Gly Glu Asn Gly 
625                 630                 635                 640 


Phe His Cys Leu Cys Pro Pro Gly Ser Leu Pro Pro Leu Cys Leu Pro 
                645                 650                 655     


Ala Asn His Pro Cys Ala His Lys Pro Cys Ser His Gly Val Cys His 
            660                 665                 670         


Asp Ala Pro Gly Gly Phe Arg Cys Val Cys Glu Pro Gly Trp Ser Gly 
        675                 680                 685             


Pro Arg Cys Ser Gln Ser Leu Ala Pro Asp Ala Cys Glu Ser Gln Pro 
    690                 695                 700                 


Cys Gln Ala Gly Gly Thr Cys Thr Ser Asp Gly Ile Gly Phe Arg Cys 
705                 710                 715                 720 


Thr Cys Ala Pro Gly Phe Gln Gly His Gln Cys Glu Val Leu Ser Pro 
                725                 730                 735     


Cys Thr Pro Ser Leu Cys Glu His Gly Gly His Cys Glu Ser Asp Pro 
            740                 745                 750         


Asp Arg Leu Thr Val Cys Ser Cys Pro Pro Gly Trp Gln Gly Pro Arg 
        755                 760                 765             


Cys Gln Gln Asp Val Asp Glu Cys Ala Gly Ala Ser Pro Cys Gly Pro 
    770                 775                 780                 


His Gly Thr Cys Thr Asn Leu Pro Gly Asn Phe Arg Cys Ile Cys His 
785                 790                 795                 800 


Arg Gly Tyr Thr Gly Pro Phe Cys Asp Gln Asp Ile Asp Asp Cys Asp 
                805                 810                 815     


Pro Asn Pro Cys Leu His Gly Gly Ser Cys Gln Asp Gly Val Gly Ser 
            820                 825                 830         


Phe Ser Cys Ser Cys Leu Asp Gly Phe Ala Gly Pro Arg Cys Ala Arg 
        835                 840                 845             


Asp Val Asp Glu Cys Leu Ser Ser Pro Cys Gly Pro Gly Thr Cys Thr 
    850                 855                 860                 


Asp His Val Ala Ser Phe Thr Cys Ala Cys Pro Pro Gly Tyr Gly Gly 
865                 870                 875                 880 


Phe His Cys Glu Ile Asp Leu Pro Asp Cys Ser Pro Ser Ser Cys Phe 
                885                 890                 895     


Asn Gly Gly Thr Cys Val Asp Gly Val Ser Ser Phe Ser Cys Leu Cys 
            900                 905                 910         


Arg Pro Gly Tyr Thr Gly Thr His Cys Gln Tyr Glu Ala Asp Pro Cys 
        915                 920                 925             


Phe Ser Arg Pro Cys Leu His Gly Gly Ile Cys Asn Pro Thr His Pro 
    930                 935                 940                 


Gly Phe Glu Cys Thr Cys Arg Glu Gly Phe Thr Gly Ser Gln Cys Gln 
945                 950                 955                 960 


Asn Pro Val Asp Trp Cys Ser Gln Ala Pro Cys Gln Asn Gly Gly Arg 
                965                 970                 975     


Cys Val Gln Thr Gly Ala Tyr Cys Ile Cys Pro Pro Gly Trp Ser Gly 
            980                 985                 990         


Arg Leu Cys Asp Ile Gln Ser Leu  Pro Cys Thr Glu Ala  Ala Ala Gln 
        995                 1000                 1005             


Met Gly  Val Arg Leu Glu Gln  Leu Cys Gln Glu Gly  Gly Lys Cys 
    1010                 1015                 1020             


Ile Asp  Lys Gly Arg Ser His  Tyr Cys Val Cys Pro  Glu Gly Arg 
    1025                 1030                 1035             


Thr Gly  Ser His Cys Glu His  Glu Val Asp Pro Cys  Thr Ala Gln 
    1040                 1045                 1050             


Pro Cys  Gln His Gly Gly Thr  Cys Arg Gly Tyr Met  Gly Gly Tyr 
    1055                 1060                 1065             


Val Cys  Glu Cys Pro Ala Gly  Tyr Ala Gly Asp Ser  Cys Glu Asp 
    1070                 1075                 1080             


Asn Ile  Asp Glu Cys Ala Ser  Gln Pro Cys Gln Asn  Gly Gly Ser 
    1085                 1090                 1095             


Cys Ile  Asp Leu Val Ala Arg  Tyr Leu Cys Ser Cys  Pro Pro Gly 
    1100                 1105                 1110             


Thr Leu  Gly Val Leu Cys Glu  Ile Asn Glu Asp Asp  Cys Asp Leu 
    1115                 1120                 1125             


Gly Pro  Ser Leu Asp Ser Gly  Val Gln Cys Leu His  Asn Gly Thr 
    1130                 1135                 1140             


Cys Val  Asp Leu Val Gly Gly  Phe Arg Cys Asn Cys  Pro Pro Gly 
    1145                 1150                 1155             


Tyr Thr  Gly Leu His Cys Glu  Ala Asp Ile Asn Glu  Cys Arg Pro 
    1160                 1165                 1170             


Gly Ala  Cys His Ala Ala His  Thr Arg Asp Cys Leu  Gln Asp Pro 
    1175                 1180                 1185             


Gly Gly  His Phe Arg Cys Val  Cys His Pro Gly Phe  Thr Gly Pro 
    1190                 1195                 1200             


Arg Cys  Gln Ile Ala Leu Ser  Pro Cys Glu Ser Gln  Pro Cys Gln 
    1205                 1210                 1215             


His Gly  Gly Gln Cys Arg His  Ser Leu Gly Arg Gly  Gly Gly Leu 
    1220                 1225                 1230             


Thr Phe  Thr Cys His Cys Val  Pro Pro Phe Trp Gly  Leu Arg Cys 
    1235                 1240                 1245             


Glu Arg  Val Ala Arg Ser Cys  Arg Glu Leu Gln Cys  Pro Val Gly 
    1250                 1255                 1260             


Ile Pro  Cys Gln Gln Thr Ala  Arg Gly Pro Arg Cys  Ala Cys Pro 
    1265                 1270                 1275             


Pro Gly  Leu Ser Gly Pro Ser  Cys Arg Val Ser Arg  Ala Ser Pro 
    1280                 1285                 1290             


Ser Gly  Ala Thr Asn Ala Ser  Cys Ala Ser Ala Pro  Cys Leu His 
    1295                 1300                 1305             


Gly Gly  Ser Cys Leu Pro Val  Gln Ser Val Pro Phe  Phe Arg Cys 
    1310                 1315                 1320             


Val Cys  Ala Pro Gly Trp Gly  Gly Pro Arg Cys Glu  Thr Pro Ser 
    1325                 1330                 1335             


Ala Ala  Pro Glu Val Pro Glu  Glu Pro Arg Cys Pro  Arg Ala Ala 
    1340                 1345                 1350             


Cys Gln  Ala Lys Arg Gly Asp  Gln Asn Cys Asp Arg  Glu Cys Asn 
    1355                 1360                 1365             


Thr Pro  Gly Cys Gly Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Val 
    1370                 1375                 1380             


Asp Asp  Pro Trp Arg Gln Cys  Glu Ala Leu Gln Cys  Trp Arg Leu 
    1385                 1390                 1395             


Phe Asn  Asn Ser Arg Cys Asp  Pro Ala Cys Ser Ser  Pro Ala Cys 
    1400                 1405                 1410             


Leu Tyr  Asp Asn Phe Asp Cys  Tyr Ser Gly Gly Arg  Asp Arg Thr 
    1415                 1420                 1425             


Cys Asn  Pro Val Tyr Glu Lys  Tyr Cys Ala Asp His  Phe Ala Asp 
    1430                 1435                 1440             


Gly Arg  Cys Asp Gln Gly Cys  Asn Thr Glu Glu Cys  Gly Trp Asp 
    1445                 1450                 1455             


Gly Leu  Asp Cys Ala Ser Glu  Val Pro Ala Leu Leu  Ala Arg Gly 
    1460                 1465                 1470             


Val Leu  Val Leu Thr Val Leu  Leu Pro Pro Glu Glu  Leu Leu Arg 
    1475                 1480                 1485             


Ser Ser  Ala Asp Phe Leu Gln  Arg Leu Ser Ala Ile  Leu Arg Thr 
    1490                 1495                 1500             


Ser Leu  Arg Phe Arg Leu Asp  Ala Arg Gly Gln Ala  Met Val Phe 
    1505                 1510                 1515             


Pro Tyr  His Arg Pro Ser Pro  Gly Ser Glu Ser Arg  Val Arg Arg 
    1520                 1525                 1530             


<210>  7
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 
            20                  25                  30          


Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 
        35                  40                  45              


Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 
65                  70                  75                  80  


Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 
                85                  90                  95      


Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 
            100                 105                 110         


Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 
        115                 120                 125             


Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 
    130                 135                 140                 


Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 
145                 150                 155                 160 


Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 
                165                 170                 175     


Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 
            180                 185                 190         


Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 
        195                 200                 205             


Asn Gly Phe Tyr His Ser Arg Gln Cys Glu Thr Ser Met Asp Gly Glu 
    210                 215                 220                 


Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro 
225                 230                 235                 240 


Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn 
                245                 250                 255     


Val Gln Asn 
            


<210>  8
<211>  1660
<212>  DNA
<213>  Homo sapiens

<400>  8
ggtgcactag caaaacaaac ttattttgaa cactcagctc ctagcgtgcg gcgctgccaa       60

tcattaacct cctggtgcaa gtggcgcggc ctgtgccctt tataaggtgc gcgctgtgtc      120

cagcgagcat cggccaccgc catcccatcc agcgagcatc tgccgccgcg ccgccgccac      180

cctcccagag agcactggcc accgctccac catcacttgc ccagagtttg ggccaccgcc      240

cgccgccacc agcccagaga gcatcggccc ctgtctgctg ctcgcgcctg gagatgtcag      300

aggtccccgt tgctcgcgtc tggctggtac tgctcctgct gactgtccag gtcggcgtga      360

cagccggcgc tccgtggcag tgcgcgccct gctccgccga gaagctcgcg ctctgcccgc      420

cggtgtccgc ctcgtgctcg gaggtcaccc ggtccgccgg ctgcggctgt tgcccgatgt      480

gcgccctgcc tctgggcgcc gcgtgcggcg tggcgactgc acgctgcgcc cggggactca      540

gttgccgcgc gctgccgggg gagcagcaac ctctgcacgc cctcacccgc ggccaaggcg      600

cctgcgtgca ggagtctgac gcctccgctc cccatgctgc agaggcaggg agccctgaaa      660

gcccagagag cacggagata actgaggagg agctcctgga taatttccat ctgatggccc      720

cttctgaaga ggatcattcc atcctttggg acgccatcag tacctatgat ggctcgaagg      780

ctctccatgt caccaacatc aaaaaatgga aggagccctg ccgaatagaa ctctacagag      840

tcgtagagag tttagccaag gcacaggaga catcaggaga agaaatttcc aaattttacc      900

tgccaaactg caacaagaat ggattttatc acagcagaca gtgtgagaca tccatggatg      960

gagaggcggg actctgctgg tgcgtctacc cttggaatgg gaagaggatc cctgggtctc     1020

cagagatcag gggagacccc aactgccaga tatattttaa tgtacaaaac tgaaaccaga     1080

tgaaataatg ttctgtcacg tgaaatattt aagtatatag tatatttata ctctagaaca     1140

tgcacattta tatatatatg tatatgtata tatatatagt aactactttt tatactccat     1200

acataacttg atatagaaag ctgtttattt attcactgta agtttatttt ttctacacag     1260

taaaaacttg tactatgtta ataacttgtc ctatgtcaat ttgtatatca tgaaacactt     1320

ctcatcatat tgtatgtaag taattgcatt tctgctcttc caaagctcct gcgtctgttt     1380

ttaaagagca tggaaaaata ctgcctagaa aatgcaaaat gaaataagag agagtagttt     1440

ttcagctagt ttgaaggagg acggttaact tgtatattcc accattcaca tttgatgtac     1500

atgtgtaggg aaagttaaaa gtgttgatta cataatcaaa gctacctgtg gtgatgttgc     1560

cacctgttaa aatgtacact ggatatgttg ttaaacacgt gtctataatg gaaacattta     1620

caataaatat tctgcatgga aatactgtta aaaaaaaaaa                           1660


<210>  9
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Gln Leu Ser Arg Ala Gly Arg Ser Ala Pro 
            20                  25                  30          


Leu Ala Ala Gly Cys Pro Asp Arg Cys Glu Pro Ala Arg Cys Pro Pro 
        35                  40                  45              


Gln Pro Glu His Cys Glu Gly Gly Arg Ala Arg Asp Ala Cys Gly Cys 
    50                  55                  60                  


Cys Glu Val Cys Gly Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu 
65                  70                  75                  80  


Gly Pro Cys Gly Glu Gly Leu Gln Cys Val Val Pro Phe Gly Val Pro 
                85                  90                  95      


Ala Ser Ala Thr Val Arg Arg Arg Ala Gln Ala Gly Leu Cys Val Cys 
            100                 105                 110         


Ala Ser Ser Glu Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn 
        115                 120                 125             


Leu Cys Gln Leu Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu His Arg 
    130                 135                 140                 


Pro Pro Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu 
145                 150                 155                 160 


Asp Pro Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val 
                165                 170                 175     


Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu 
            180                 185                 190         


Pro Phe Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile 
        195                 200                 205             


Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn 
    210                 215                 220                 


Lys His Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala 
225                 230                 235                 240 


Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile 
                245                 250                 255     


Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu 
            260                 265                 270         


Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu 
        275                 280                 285             


Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly 
    290                 295                 300                 


Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp 
305                 310                 315                 320 


Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp 
                325                 330                 335     


Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser 
            340                 345                 350         


Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His 
        355                 360                 365             


Asp Arg Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly 
    370                 375                 380                 


Ile Arg Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp 
385                 390                 395                 400 


Arg His Arg Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu 
                405                 410                 415     


Val Ile Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp 
            420                 425                 430         


Val Ile Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val 
        435                 440                 445             


Ser Asp Val Ile Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg 
    450                 455                 460                 


Gly Asn Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
465                 470                 475                 480 


<210>  10
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  positions 1-22 of (SEQ ID NO: 9) which correspond to the signal 
       peptide

<400>  10

Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala 
            20          


<210>  11
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  positions 204-364 of SEQ ID NO: 9 which correspond to a serine 
       protease domain

<400>  11

Gly Ser Gly Phe Ile Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala 
1               5                   10                  15      


His Val Val Thr Asn Lys His Arg Val Lys Val Glu Leu Lys Asn Gly 
            20                  25                  30          


Ala Thr Tyr Glu Ala Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile 
        35                  40                  45              


Ala Leu Ile Lys Ile Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu 
    50                  55                  60                  


Gly Arg Ser Ser Glu Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly 
65                  70                  75                  80  


Ser Pro Phe Ser Leu Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr 
                85                  90                  95      


Thr Gln Arg Gly Gly Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp 
            100                 105                 110         


Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro 
        115                 120                 125             


Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val 
    130                 135                 140                 


Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe 
145                 150                 155                 160 


Leu 
    


<210>  12
<211>  2138
<212>  DNA
<213>  Homo sapiens

<400>  12
caatgggctg ggccgcgcgg ccgcgcgcac tcgcacccgc tgcccccgag gccctcctgc       60

actctccccg gcgccgctct ccggccctcg ccctgtccgc cgccaccgcc gccgccgcca      120

gagtcgccat gcagatcccg cgcgccgctc ttctcccgct gctgctgctg ctgctggcgg      180

cgcccgcctc ggcgcagctg tcccgggccg gccgctcggc gcctttggcc gccgggtgcc      240

cagaccgctg cgagccggcg cgctgcccgc cgcagccgga gcactgcgag ggcggccggg      300

cccgggacgc gtgcggctgc tgcgaggtgt gcggcgcgcc cgagggcgcc gcgtgcggcc      360

tgcaggaggg cccgtgcggc gaggggctgc agtgcgtggt gcccttcggg gtgccagcct      420

cggccacggt gcggcggcgc gcgcaggccg gcctctgtgt gtgcgccagc agcgagccgg      480

tgtgcggcag cgacgccaac acctacgcca acctgtgcca gctgcgcgcc gccagccgcc      540

gctccgagag gctgcaccgg ccgccggtca tcgtcctgca gcgcggagcc tgcggccaag      600

ggcaggaaga tcccaacagt ttgcgccata aatataactt tatcgcggac gtggtggaga      660

agatcgcccc tgccgtggtt catatcgaat tgtttcgcaa gcttccgttt tctaaacgag      720

aggtgccggt ggctagtggg tctgggttta ttgtgtcgga agatggactg atcgtgacaa      780

atgcccacgt ggtgaccaac aagcaccggg tcaaagttga gctgaagaac ggtgccactt      840

acgaagccaa aatcaaggat gtggatgaga aagcagacat cgcactcatc aaaattgacc      900

accagggcaa gctgcctgtc ctgctgcttg gccgctcctc agagctgcgg ccgggagagt      960

tcgtggtcgc catcggaagc ccgttttccc ttcaaaacac agtcaccacc gggatcgtga     1020

gcaccaccca gcgaggcggc aaagagctgg ggctccgcaa ctcagacatg gactacatcc     1080

agaccgacgc catcatcaac tatggaaact cgggaggccc gttagtaaac ctggacggtg     1140

aagtgattgg aattaacact ttgaaagtga cagctggaat ctcctttgca atcccatctg     1200

ataagattaa aaagttcctc acggagtccc atgaccgaca ggccaaagga aaagccatca     1260

ccaagaagaa gtatattggt atccgaatga tgtcactcac gtccagcaaa gccaaagagc     1320

tgaaggaccg gcaccgggac ttcccagacg tgatctcagg agcgtatata attgaagtaa     1380

ttcctgatac cccagcagaa gctggtggtc tcaaggaaaa cgacgtcata atcagcatca     1440

atggacagtc cgtggtctcc gccaatgatg tcagcgacgt cattaaaagg gaaagcaccc     1500

tgaacatggt ggtccgcagg ggtaatgaag atatcatgat cacagtgatt cccgaagaaa     1560

ttgacccata ggcagaggca tgagctggac ttcatgtttc cctcaaagac tctcccgtgg     1620

atgacggatg aggactctgg gctgctggaa taggacactc aagacttttg actgccattt     1680

tgtttgttca gtggagactc cctggccaac agaatccttc ttgatagttt gcaggcaaaa     1740

caaatgtaat gttgcagatc cgcaggcaga agctctgccc ttctgtatcc tatgtatgca     1800

gtgtgctttt tcttgccagc ttgggccatt cttgcttaga cagtcagcat ttgtctcctc     1860

ctttaactga gtcatcatct tagtccaact aatgcagtcg atacaatgcg tagatagaag     1920

aagccccacg ggagccagga tgggactggt cgtgtttgtg cttttctcca agtcagcacc     1980

caaaggtcaa tgcacagaga ccccgggtgg gtgagcgctg gcttctcaaa cggccgaagt     2040

tgcctctttt aggaatctct ttggaattgg gagcacgatg actctgagtt tgagctatta     2100

aagtacttct tacacattgc aaaaaaaaaa aaaaaaaa                             2138


<210>  13
<211>  8089
<212>  DNA
<213>  Homo sapiens

<400>  13
gcggcgcgga ggctggcccg ggacgcgccc ggagcccagg gaaggaggga ggaggggagg       60

gtcgcggccg gccgccatgg ggccgggggc ccgtggccgc cgccgccgcc gtcgcccgat      120

gtcgccgcca ccgccaccgc cacccgtgcg ggcgctgccc ctgctgctgc tgctagcggg      180

gccgggggct gcagcccccc cttgcctgga cggaagcccg tgtgcaaatg gaggtcgttg      240

cacccagctg ccctcccggg aggctgcctg cctgtgcccg cctggctggg tgggtgagcg      300

gtgtcagctg gaggacccct gtcactcagg cccctgtgct ggccgtggtg tctgccagag      360

ttcagtggtg gctggcaccg cccgattctc atgccggtgc ccccgtggct tccgaggccc      420

tgactgctcc ctgccagatc cctgcctcag cagcccttgt gcccacggtg cccgctgctc      480

agtggggccc gatggacgct tcctctgctc ctgcccacct ggctaccagg gccgcagctg      540

ccgaagcgac gtggatgagt gccgggtggg tgagccctgc cgccatggtg gcacctgcct      600

caacacacct ggctccttcc gctgccagtg tccagctggc tacacagggc cactatgtga      660

gaaccccgcg gtgccctgtg caccctcacc atgccgtaac gggggcacct gcaggcagag      720

tggcgacctc acttacgact gtgcctgtct tcctgggttt gagggtcaga attgtgaagt      780

gaacgtggac gactgtccag gacaccgatg tctcaatggg gggacatgcg tggatggcgt      840

caacacctat aactgccagt gccctcctga gtggacaggc cagttctgca cggaggacgt      900

ggatgagtgt cagctgcagc ccaacgcctg ccacaatggg ggtacctgct tcaacacgct      960

gggtggccac agctgcgtgt gtgtcaatgg ctggacaggc gagagctgca gtcagaatat     1020

cgatgactgt gccacagccg tgtgcttcca tggggccacc tgccatgacc gcgtggcttc     1080

tttctactgt gcctgcccca tgggcaagac tggcctcctg tgtcacctgg atgacgcctg     1140

tgtcagcaac ccctgccacg aggatgctat ctgtgacaca aatccggtga acggccgggc     1200

catttgcacc tgtcctcccg gcttcacggg tggggcatgt gaccaggatg tggacgagtg     1260

ctctatcggc gccaacccct gcgagcactt gggcaggtgc gtgaacacgc agggctcctt     1320

cctgtgccag tgcggtcgtg gctacactgg acctcgctgt gagaccgatg tcaacgagtg     1380

tctgtcgggg ccctgccgaa accaggccac gtgcctcgac cgcataggcc agttcacctg     1440

tatctgtatg gcaggcttca caggaaccta ttgcgaggtg gacattgacg agtgtcagag     1500

tagcccctgt gtcaacggtg gggtctgcaa ggaccgagtc aatggcttca gctgcacctg     1560

cccctcgggc ttcagcggct ccacgtgtca gctggacgtg gacgaatgcg ccagcacgcc     1620

ctgcaggaat ggcgccaaat gcgtggacca gcccgatggc tacgagtgcc gctgtgccga     1680

gggctttgag ggcacgctgt gtgatcgcaa cgtggacgac tgctcccctg acccatgcca     1740

ccatggtcgc tgcgtggatg gcatcgccag cttctcatgt gcctgtgctc ctggctacac     1800

gggcacacgc tgcgagagcc aggtggacga atgccgcagc cagccctgcc gccatggcgg     1860

caaatgccta gacctggtgg acaagtacct ctgccgctgc ccttctggga ccacaggtgt     1920

gaactgcgaa gtgaacattg acgactgtgc cagcaacccc tgcacctttg gagtctgccg     1980

tgatggcatc aaccgctacg actgtgtctg ccaacctggc ttcacagggc ccctttgtaa     2040

cgtggagatc aatgagtgtg cttccagccc atgcggcgag ggaggttcct gtgtggatgg     2100

ggaaaatggc ttccgctgcc tctgcccgcc tggctccttg cccccactct gcctcccccc     2160

gagccatccc tgtgcccatg agccctgcag tcacggcatc tgctatgatg cacctggcgg     2220

gttccgctgt gtgtgtgagc ctggctggag tggcccccgc tgcagccaga gcctggcccg     2280

agacgcctgt gagtcccagc cgtgcagggc cggtgggaca tgcagcagcg atggaatggg     2340

tttccactgc acctgcccgc ctggtgtcca gggacgtcag tgtgaactcc tctccccctg     2400

caccccgaac ccctgtgagc atgggggccg ctgcgagtct gcccctggcc agctgcctgt     2460

ctgctcctgc ccccagggct ggcaaggccc acgatgccag caggatgtgg acgagtgtgc     2520

tggccccgca ccctgtggcc ctcatggtat ctgcaccaac ctggcaggga gtttcagctg     2580

cacctgccat ggagggtaca ctggcccttc ctgcgatcag gacatcaatg actgtgaccc     2640

caacccatgc ctgaacggtg gctcgtgcca agacggcgtg ggctcctttt cctgctcctg     2700

cctccctggt ttcgccggcc cacgatgcgc ccgcgatgtg gatgagtgcc tgagcaaccc     2760

ctgcggcccg ggcacctgta ccgaccacgt ggcctccttc acctgcacct gcccgccagg     2820

ctacggaggc ttccactgcg aacaggacct gcccgactgc agccccagct cctgcttcaa     2880

tggcgggacc tgtgtggacg gcgtgaactc gttcagctgc ctgtgccgtc ccggctacac     2940

aggagcccac tgccaacatg aggcagaccc ctgcctctcg cggccctgcc tacacggggg     3000

cgtctgcagc gccgcccacc ctggcttccg ctgcacctgc ctcgagagct tcacgggccc     3060

gcagtgccag acgctggtgg attggtgcag ccgccagcct tgtcaaaacg ggggtcgctg     3120

cgtccagact ggggcctatt gcctttgtcc ccctggatgg agcggacgcc tctgtgacat     3180

ccgaagcttg ccctgcaggg aggccgcagc ccagatcggg gtgcggctgg agcagctgtg     3240

tcaggcgggt gggcagtgtg tggatgaaga cagctcccac tactgcgtgt gcccagaggg     3300

ccgtactggt agccactgtg agcaggaggt ggacccctgc ttggcccagc cctgccagca     3360

tggggggacc tgccgtggct atatgggggg ctacatgtgt gagtgtcttc ctggctacaa     3420

tggtgataac tgtgaggacg acgtggacga gtgtgcctcc cagccctgcc agcacggggg     3480

ttcatgcatt gacctcgtgg cccgctatct ctgctcctgt cccccaggaa cgctgggggt     3540

gctctgcgag attaatgagg atgactgcgg cccaggccca ccgctggact cagggccccg     3600

gtgcctacac aatggcacct gcgtggacct ggtgggtggt ttccgctgca cctgtccccc     3660

aggatacact ggtttgcgct gcgaggcaga catcaatgag tgtcgctcag gtgcctgcca     3720

cgcggcacac acccgggact gcctgcagga cccaggcgga ggtttccgtt gcctttgtca     3780

tgctggcttc tcaggtcctc gctgtcagac tgtcctgtct ccctgcgagt cccagccatg     3840

ccagcatgga ggccagtgcc gtcctagccc gggtcctggg ggtgggctga ccttcacctg     3900

tcactgtgcc cagccgttct ggggtccgcg ttgcgagcgg gtggcgcgct cctgccggga     3960

gctgcagtgc ccggtgggcg tcccatgcca gcagacgccc cgcgggccgc gctgcgcctg     4020

ccccccaggg ttgtcgggac cctcctgccg cagcttcccg gggtcgccgc cgggggccag     4080

caacgccagc tgcgcggccg ccccctgtct ccacgggggc tcctgccgcc ccgcgccgct     4140

cgcgcccttc ttccgctgcg cttgcgcgca gggctggacc gggccgcgct gcgaggcgcc     4200

cgccgcggca cccgaggtct cggaggagcc gcggtgcccg cgcgccgcct gccaggccaa     4260

gcgcggggac cagcgctgcg accgcgagtg caacagccca ggctgcggct gggacggcgg     4320

cgactgctcg ctgagcgtgg gcgacccctg gcggcaatgc gaggcgctgc agtgctggcg     4380

cctcttcaac aacagccgct gcgaccccgc ctgcagctcg cccgcctgcc tctacgacaa     4440

cttcgactgc cacgccggtg gccgcgagcg cacttgcaac ccggtgtacg agaagtactg     4500

cgccgaccac tttgccgacg gccgctgcga ccagggctgc aacacggagg agtgcggctg     4560

ggatgggctg gattgtgcca gcgaggtgcc ggccctgctg gcccgcggcg tgctggtgct     4620

cacagtgctg ctgccgccag aggagctact gcgttccagc gccgactttc tgcagcggct     4680

cagcgccatc ctgcgcacct cgctgcgctt ccgcctggac gcgcacggcc aggccatggt     4740

cttcccttac caccggccta gtcctggctc cgaaccccgg gcccgtcggg agctggcccc     4800

cgaggtgatc ggctcggtag taatgctgga gattgacaac cggctctgcc tgcagtcgcc     4860

tgagaatgat cactgcttcc ccgatgccca gagcgccgct gactacctgg gagcgttgtc     4920

agcggtggag cgcctggact tcccgtaccc actgcgggac gtgcgggggg agccgctgga     4980

gcctccagaa cccagcgtcc cgctgctgcc actgctagtg gcgggcgctg tcttgctgct     5040

ggtcattctc gtcctgggtg tcatggtggc ccggcgcaag cgcgagcaca gcaccctctg     5100

gttccctgag ggcttctcac tgcacaagga cgtggcctct ggtcacaagg gccggcggga     5160

acccgtgggc caggacgcgc tgggcatgaa gaacatggcc aagggtgaga gcctgatggg     5220

ggaggtggcc acagactgga tggacacaga gtgcccagag gccaagcggc taaaggtaga     5280

ggagccaggc atgggggctg aggaggctgt ggattgccgt cagtggactc aacaccatct     5340

ggttgctgct gacatccgcg tggcaccagc catggcactg acaccaccac agggcgacgc     5400

agatgctgat ggcatggatg tcaatgtgcg tggcccagat ggcttcaccc cgctaatgct     5460

ggcttccttc tgtggggggg ctctggagcc aatgccaact gaagaggatg aggcagatga     5520

cacatcagct agcatcatct ccgacctgat ctgccagggg gctcagcttg gggcacggac     5580

tgaccgtact ggcgagactg ctttgcacct ggctgcccgt tatgcccgtg ctgatgcagc     5640

caagcggctg ctggatgctg gggcagacac caatgcccag gaccactcag gccgcactcc     5700

cctgcacaca gctgtcacag ccgatgccca gggtgtcttc cagattctca tccgaaaccg     5760

ctctacagac ttggatgccc gcatggcaga tggctcaacg gcactgatcc tggcggcccg     5820

cctggcagta gagggcatgg tggaagagct catcgccagc catgctgatg tcaatgctgt     5880

ggatgagctt gggaaatcag ccttacactg ggctgcggct gtgaacaacg tggaagccac     5940

tttggccctg ctcaaaaatg gagccaataa ggacatgcag gatagcaagg aggagacccc     6000

cctattcctg gccgcccgcg agggcagcta tgaggctgcc aagctgctgt tggaccactt     6060

tgccaaccgt gagatcaccg accacctgga caggctgccg cgggacgtag cccaggagag     6120

actgcaccag gacatcgtgc gcttgctgga tcaacccagt gggccccgca gcccccccgg     6180

tccccacggc ctggggcctc tgctctgtcc tccaggggcc ttcctccctg gcctcaaagc     6240

ggcacagtcg gggtccaaga agagcaggag gccccccggg aaggcggggc tggggccgca     6300

ggggccccgg gggcggggca agaagctgac gctggcctgc ccgggccccc tggctgacag     6360

ctcggtcacg ctgtcgcccg tggactcgct ggactccccg cggcctttcg gtgggccccc     6420

tgcttcccct ggtggcttcc cccttgaggg gccctatgca gctgccactg ccactgcagt     6480

gtctctggca cagcttggtg gcccaggccg ggcgggtcta gggcgccagc cccctggagg     6540

atgtgtactc agcctgggcc tgctgaaccc tgtggctgtg cccctcgatt gggcccggct     6600

gcccccacct gcccctccag gcccctcgtt cctgctgcca ctggcgccgg gaccccagct     6660

gctcaaccca gggacccccg tctccccgca ggagcggccc ccgccttacc tggcagtccc     6720

aggacatggc gaggagtacc cggcggctgg ggcacacagc agccccccaa aggcccgctt     6780

cctgcgggtt cccagtgagc acccttacct gaccccatcc cccgaatccc ctgagcactg     6840

ggccagcccc tcacctccct ccctctcaga ctggtccgaa tccacgccta gcccagccac     6900

tgccactggg gccatggcca ccaccactgg ggcactgcct gcccagccac ttcccttgtc     6960

tgttcccagc tcccttgctc aggcccagac ccagctgggg ccccagccgg aagttacccc     7020

caagaggcaa gtgttggcct gagacgctcg tcagttctta gatcttgggg gcctaaagag     7080

acccccgtcc tgcctccttt ctttctctgt ctcttccttc cttttagtct ttttcatcct     7140

cttctctttc caccaaccct cctgcatcct tgccttgcag cgtgaccgag ataggtcatc     7200

agcccagggc ttcagtcttc ctttatttat aatgggtggg ggctaccacc caccctctca     7260

gtcttgtgaa gagtctggga cctccttctt ccccacttct ctcttccctc attcctttct     7320

ctctccttct ggcctctcat ttccttacac tctgacatga atgaattatt attattttta     7380

tttttctttt tttttttaca ttttgtatag aaacaaattc atttaaacaa acttattatt     7440

attatttttt acaaaatata tatatggaga tgctccctcc ccctgtgaac cccccagtgc     7500

ccccgtgggg ctgagtctgt gggcccattc ggccaagctg gattctgtgt acctagtaca     7560

caggcatgac tgggatcccg tgtaccgagt acacgaccca ggtatgtacc aagtaggcac     7620

ccttgggcgc acccactggg gccaggggtc gggggagtgt tgggagcctc ctccccaccc     7680

cacctccctc acttcactgc attccagatg ggacatgttc catagccttg ctggggaagg     7740

gcccactgcc aactccctct gccccagccc cacccttggc catctccctt tgggaactag     7800

ggggctgctg gtgggaaatg ggagccaggg cagatgtatg cattcctttg tgtccctgta     7860

aatgtgggac tacaagaaga ggagctgcct gagtggtact ttctcttcct ggtaatcctc     7920

tggcccagcc tcatggcaga atagaggtat ttttaggcta tttttgtaat atggcttctg     7980

gtcaaaatcc ctgtgtagct gaattcccaa gccctgcatt gtacagcccc ccactcccct     8040

caccacctaa taaaggaata gttaacactc aaaaaaaaaa aaaaaaaaa                 8089


<210>  14
<211>  2321
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Val 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


