                         SEQUENCE LISTING

<110>  Centauri Therapeutics Limited
 
<120>  NOVEL COMPOUNDS AND THERAPEUTIC USES THEREOF

<130>  CEN-C-P2159PCT

<150>  1705684.7
<151>  2017-04-07

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  43
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (36)..(38)
<223>  2'OMe substituted nucleotide

<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  2'-F substituted nucleotide

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  idT

<400>  1
gggauuuaau cgccguagaa aagcauguca aagccggaac ccn                         43


<210>  2
<211>  44
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (20)..(24)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (39)..(43)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  idT

<400>  2
gggaccgaaa aagaccugac uucuauacua agucuacguu cccn                        44


<210>  3
<211>  56
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (30)..(32)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (33)..(36)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (37)..(39)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (40)..(47)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (49)..(53)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  idT

<400>  3
gugcagaucc ggguauaaug gguaguggag gguuucgggc uauaccagau cuugun           56


<210>  4
<211>  56
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (25)..(28)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (29)..(31)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (37)..(40)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (41)..(43)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (44)..(53)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  idT

<400>  4
gugcagauug gaaaagggua guggauuugg gaaggguuua ggguuucaau cuugun           56


<210>  5
<211>  48
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (46)..(48)
<223>  modified 2'-fluoro nucleotide

<400>  5
ggacggauuu aaucgccgua gaaaagcaug ucaaagccgg aaccgucc                    48


<210>  6
<211>  42
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (36)..(38)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  modified 2'-fluoro nucleotide

<400>  6
gggauuuaau cgccguagaa aagcauguca aagccggaac cc                          42


<210>  7
<211>  43
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (20)..(24)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (39)..(43)
<223>  modified 2'-fluoro nucleotide

<400>  7
gggaccgaaa aagaccugac uucuauacua agucuacguu ccc                         43


<210>  8
<211>  43
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (20)..(24)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (32)..(35)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  modified 2'-methoxy nucleotide

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  modified 2'-fluoro nucleotide

<220>
<221>  misc_feature
<222>  (40)..(43)
<223>  modified 2'-methoxy nucleotide

<400>  8
cggaccgaaa aagaccugac uucuauacua agucuacguu ccg                         43


<210>  9
<211>  55
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  9
gugcagaucc ggguauaaug gguaguggag gguuucgggc uauaccagau cuugu            55


<210>  10
<211>  55
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  10
gugcagauug gaaaagggua guggauuugg gaaggguuua ggguuucaau cuugu            55


<210>  11
<211>  55
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  11
gugcagauaa acgggaaggg gucgggaaaa agggcaauau caagcgcaau cuugu            55


<210>  12
<211>  59
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  12
ggggcagaua aacgggaagg ggucgggaaa aagggcaaua ucaagcgcaa ucuuguccc        59


<210>  13
<211>  45
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  13
gugcagaucg ggaaggucgg gaaaagggcu aucgcgcaau cuugu                       45


<210>  14
<211>  55
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  14
gugcagauaa gcgggaaggg uucgggaaau ugggccuuau cccgcucuau cucgc            55


<210>  15
<211>  59
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  15
ggggcagauc cggguauaau ggguagugga ggguuucggg cuauaccaga ucuuguccc        59


<210>  16
<211>  45
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  16
gugcagccgg gauaauguag uggaggguuu cggcauccag cuugu                       45


<210>  17
<211>  55
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  17
gugcugaucc ggguaucaug gguggucgag gguuuggcgc gauacccgau cgugc            55


<210>  18
<211>  45
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  18
gugcagccgg gauaauggaa acgugggaau gaucauccag cuugc                       45


<210>  19
<211>  45
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  19
gugcugccgg gaucaugugg ucgaggguuu cgggaucccg cgugc                       45


<210>  20
<211>  36
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  20
gccgggauaa uggaaacgug ggaaugauca uccagc                                 36


<210>  21
<211>  36
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  21
gccgggauca uguggucgag gguuucggga ucccgc                                 36


<210>  22
<211>  59
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  22
ggggcagauu ggaaaagggu aguggauuug ggaaggguuu aggguuucaa ucuuguccc        59


<210>  23
<211>  45
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  23
gugcagauga aaaggguagu auugggaagg uaggguucau cuugu                       45


<210>  24
<211>  55
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  24
gugcggauug gaacaggguc uaggauuugg gaagguuuua ggguuucaau ccugc            55


<210>  25
<211>  45
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  25
gugcagauga aaaggguagu guugggaagg caggguucau cuugc                       45


<210>  26
<211>  45
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  26
gugcggauga acagggucua auugggaagg uaggguucau cuugc                       45


<210>  27
<211>  36
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  27
gaugaaaagg guaguguugg gaaggcaggg uucauc                                 36


<210>  28
<211>  36
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  28
gaugaacagg gucuaauugg gaagguaggg uucauc                                 36


<210>  29
<211>  56
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  29
gugcagaguu acacgccaug ggauuuaggg gaaggaagug ggggucgugu ucuugu           56


<210>  30
<211>  60
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  30
ggggcagagu uacacgccau gggauuuagg ggaaggaagu gggggucgug uucuuguccc       60


<210>  31
<211>  56
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  31
gugcucuguu acacgccacg ggauugaagg caagaaagug gaggacgugu ucaagc           56


<210>  32
<211>  48
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  32
gugcagaguu acgcauggga uuaggggaag gaaugggguc guucuugu                    48


<210>  33
<211>  85
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  33
ggaagaggaa agaagugcag auaaacggga aggggucggg aaaaagggca auaucaagcg       60

caaucuugug cucgcgaggc aauca                                             85


<210>  34
<211>  85
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  34
ggaagaggaa agaagugcag auccggguau aauggguagu ggaggguuuc gggcuauacc       60

agaucuugug cucgcgaggc aauca                                             85


<210>  35
<211>  85
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  35
ggaagaggaa agaagugcag auuggaaaag gguaguggau uugggaaggg uuuaggguuu       60

caaucuugug cucgcgaggc aauca                                             85


<210>  36
<211>  86
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  36
ggaagaggaa agaagugcag aguuacacgc caugggauuu aggggaagga aguggggguc       60

guguucuugu gcucgcgagg caauca                                            86


<210>  37
<211>  61
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic Aptamer

<400>  37
ugagugccau ugguuacagg auguuucugg uugaaucugg aaugcauugc aucacgucgc       60

u                                                                       61


