                         SEQUENCE LISTING

<110>  Heat Biologics, Inc.
       DE SILVA, Suresh
       SCHREIBER, Taylor H.
 
<120>  INTRATUMORAL VACCINATION

<130>  HTB-024PC

<150>  US62/481,219
<151>  2017-04-04

<150>  US62/599,458
<151>  2017-15-12

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  2412
<212>  DNA
<213>  Homo sapiens

<400>  1
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gctgacgatg aagttgatgt ggatggtaca gtagaagagg atctgggtaa aagtagagaa      120

ggatcaagga cggatgatga agtagtacag agagaggaag aagctattca gttggatgga      180

ttaaatgcat cacaaataag agaacttaga gagaagtcgg aaaagtttgc cttccaagcc      240

gaagttaaca gaatgatgaa acttatcatc aattcattgt ataaaaataa agagattttc      300

ctgagagaac tgatttcaaa tgcttctgat gctttagata agataaggct aatatcactg      360

actgatgaaa atgctctttc tggaaatgag gaactaacag tcaaaattaa gtgtgataag      420

gagaagaacc tgctgcatgt cacagacacc ggtgtaggaa tgaccagaga agagttggtt      480

aaaaaccttg gtaccatagc caaatctggg acaagcgagt ttttaaacaa aatgactgaa      540

gcacaggaag atggccagtc aacttctgaa ttgattggcc agtttggtgt cggtttctat      600

tccgccttcc ttgtagcaga taaggttatt gtcacttcaa aacacaacaa cgatacccag      660

cacatctggg agtctgactc caatgaattt tctgtaattg ctgacccaag aggaaacact      720

ctaggacggg gaacgacaat tacccttgtc ttaaaagaag aagcatctga ttaccttgaa      780

ttggatacaa ttaaaaatct cgtcaaaaaa tattcacagt tcataaactt tcctatttat      840

gtatggagca gcaagactga aactgttgag gagcccatgg aggaagaaga agcagccaaa      900

gaagagaaag aagaatctga tgatgaagct gcagtagagg aagaagaaga agaaaagaaa      960

ccaaagacta aaaaagttga aaaaactgtc tgggactggg aacttatgaa tgatatcaaa     1020

ccaatatggc agagaccatc aaaagaagta gaagaagatg aatacaaagc tttctacaaa     1080

tcattttcaa aggaaagtga tgaccccatg gcttatattc actttactgc tgaaggggaa     1140

gttaccttca aatcaatttt atttgtaccc acatctgctc cacgtggtct gtttgacgaa     1200

tatggatcta aaaagagcga ttacattaag ctctatgtgc gccgtgtatt catcacagac     1260

gacttccatg atatgatgcc taaatacctc aattttgtca agggtgtggt ggactcagat     1320

gatctcccct tgaatgtttc ccgcgagact cttcagcaac ataaactgct taaggtgatt     1380

aggaagaagc ttgttcgtaa aacgctggac atgatcaaga agattgctga tgataaatac     1440

aatgatactt tttggaaaga atttggtacc aacatcaagc ttggtgtgat tgaagaccac     1500

tcgaatcgaa cacgtcttgc taaacttctt aggttccagt cttctcatca tccaactgac     1560

attactagcc tagaccagta tgtggaaaga atgaaggaaa aacaagacaa aatctacttc     1620

atggctgggt ccagcagaaa agaggctgaa tcttctccat ttgttgagcg acttctgaaa     1680

aagggctatg aagttattta cctcacagaa cctgtggatg aatactgtat tcaggccctt     1740

cccgaatttg atgggaagag gttccagaat gttgccaagg aaggagtgaa gttcgatgaa     1800

agtgagaaaa ctaaggagag tcgtgaagca gttgagaaag aatttgagcc tctgctgaat     1860

tggatgaaag ataaagccct taaggacaag attgaaaagg ctgtggtgtc tcagcgcctg     1920

acagaatctc cgtgtgcttt ggtggccagc cagtacggat ggtctggcaa catggagaga     1980

atcatgaaag cacaagcgta ccaaacgggc aaggacatct ctacaaatta ctatgcgagt     2040

cagaagaaaa catttgaaat taatcccaga cacccgctga tcagagacat gcttcgacga     2100

attaaggaag atgaagatga taaaacagtt ttggatcttg ctgtggtttt gtttgaaaca     2160

gcaacgcttc ggtcagggta tcttttacca gacactaaag catatggaga tagaatagaa     2220

agaatgcttc gcctcagttt gaacattgac cctgatgcaa aggtggaaga agagcccgaa     2280

gaagaacctg aagagacagc agaagacaca acagaagaca cagagcaaga cgaagatgaa     2340

gaaatggatg tgggaacaga tgaagaagaa gaaacagcaa aggaatctac agctgaaaaa     2400

gatgaattgt aa                                                         2412


<210>  2
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  3
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Asp Glu Leu 
1               


<210>  4
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4
atgagactgg gaagccctgg cctgctgttt ctgctgttca gcagcctgag agccgacacc       60

caggaaaaag aagtgcgggc catggtggga agcgacgtgg aactgagctg cgcctgtcct      120

gagggcagca gattcgacct gaacgacgtg tacgtgtact ggcagaccag cgagagcaag      180

accgtcgtga cctaccacat cccccagaac agctccctgg aaaacgtgga cagccggtac      240

agaaaccggg ccctgatgtc tcctgccggc atgctgagag gcgacttcag cctgcggctg      300

ttcaacgtga ccccccagga cgagcagaaa ttccactgcc tggtgctgag ccagagcctg      360

ggcttccagg aagtgctgag cgtggaagtg accctgcacg tggccgccaa tttcagcgtg      420

ccagtggtgt ctgcccccca cagcccttct caggatgagc tgaccttcac ctgtaccagc      480

atcaacggct accccagacc caatgtgtac tggatcaaca agaccgacaa cagcctgctg      540

gaccaggccc tgcagaacga taccgtgttc ctgaacatgc ggggcctgta cgacgtggtg      600

tccgtgctga gaatcgccag aacccccagc gtgaacatcg gctgctgcat cgagaacgtg      660

ctgctgcagc agaacctgac cgtgggcagc cagaccggca acgacatcgg cgagagagac      720

aagatcaccg agaaccccgt gtccaccggc gagaagaatg ccgccacctc taagtacggc      780

cctccctgcc cttcttgccc agcccctgaa tttctgggcg gaccctccgt gtttctgttc      840

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      900

gtggatgtgt cccaggaaga tcccgaggtg cagttcaatt ggtacgtgga cggggtggaa      960

gtgcacaacg ccaagaccaa gcccagagag gaacagttca acagcaccta ccgggtggtg     1020

tctgtgctga ccgtgctgca ccaggattgg ctgagcggca aagagtacaa gtgcaaggtg     1080

tccagcaagg gcctgcccag cagcatcgaa aagaccatca gcaacgccac cggccagccc     1140

agggaacccc aggtgtacac actgccccct agccaggaag agatgaccaa gaaccaggtg     1200

tccctgacct gtctcgtgaa gggcttctac ccctccgata tcgccgtgga atgggagagc     1260

aacggccagc cagagaacaa ctacaagacc acccccccag tgctggacag cgacggctca     1320

ttcttcctgt actcccggct gacagtggac aagagcagct ggcaggaagg caacgtgttc     1380

agctgcagcg tgatgcacga agccctgcac aaccactaca cccagaagtc cctgtctctg     1440

tccctgggca aatga                                                      1455


<210>  5
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Ser Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Leu Gly Lys 
                


<210>  6
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6
atgtctaagt acggccctcc ctgccctagc tgccctgccc ctgaatttct gggcggaccc       60

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa      120

gtgacctgcg tggtggtgga tgtgtcccag gaagatcccg aggtgcagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgag cggcaaagag      300

tacaagtgca aggtgtccag caagggcctg cccagcagca tcgagaaaac catcagcaac      360

gccaccggcc agcccaggga accccaggtg tacacactgc cccctagcca ggaagagatg      420

accaagaacc aggtgtccct gacctgtctc gtgaagggct tctacccctc cgatatcgcc      480

gtggaatggg agagcaacgg ccagcctgag aacaactaca agaccacccc cccagtgctg      540

gacagcgacg gctcattctt cctgtacagc agactgaccg tggacaagag cagctggcag      600

gaaggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctgt ctctgagcct gggcaaggcc tgtccatggg ctgtgtctgg cgctagagcc      720

tctcctggat ctgccgccag ccccagactg agagagggac ctgagctgag ccccgatgat      780

cctgccggac tgctggatct gagacagggc atgttcgccc agctggtggc ccagaacgtg      840

ctgctgatcg atggccccct gagctggtac agcgatcctg gactggctgg cgtgtcactg      900

acaggcggcc tgagctacaa agaggacacc aaagaactgg tggtggccaa ggccggcgtg      960

tactacgtgt tctttcagct ggaactgcgg agagtggtgg ccggcgaagg atccggctct     1020

gtgtctctgg ctctgcatct gcagcccctg agatctgctg ctggcgctgc tgctctggcc     1080

ctgacagtgg acctgcctcc tgcctctagc gaggccagaa acagcgcatt cgggtttcaa     1140

ggcagactgc tgcacctgtc tgccggccag agactgggag tgcatctgca cacagaggcc     1200

agagccaggc acgcctggca gctgactcag ggcgctacag tgctgggcct gttcagagtg     1260

acccccgaga ttccagccgg cctgcctagc cccagatccg aatga                     1305


<210>  7
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Met Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
225                 230                 235                 240 


Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
                245                 250                 255     


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
            260                 265                 270         


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
        275                 280                 285             


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
    290                 295                 300                 


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
305                 310                 315                 320 


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
                325                 330                 335     


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
            340                 345                 350         


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
        355                 360                 365             


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
    370                 375                 380                 


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
385                 390                 395                 400 


Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
                405                 410                 415     


Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
            420                 425                 430         


Ser Glu 
        


<210>  8
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8
atgtctaagt acggccctcc ctgccctagc tgccctgccc ctgaatttct gggcggaccc       60

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa      120

gtgacctgcg tggtggtgga tgtgtcccag gaagatcccg aggtgcagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgag cggcaaagag      300

tacaagtgca aggtgtccag caagggcctg cccagcagca tcgagaaaac catcagcaac      360

gccaccggcc agcccaggga accccaggtg tacacactgc cccctagcca ggaagagatg      420

accaagaacc aggtgtccct gacctgtctc gtgaagggct tctacccctc cgatatcgcc      480

gtggaatggg agagcaacgg ccagcctgag aacaactaca agaccacccc cccagtgctg      540

gacagcgacg gctcattctt cctgtacagc agactgaccg tggacaagag cagctggcag      600

gaaggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctgt ctctgagcct gggcaagatc gagggccgga tggatagagc ccagggcgaa      720

gcctgcgtgc agttccaggc tctgaagggc caggaattcg cccccagcca ccagcaggtg      780

tacgcccctc tgagagccga cggcgataag cctagagccc acctgacagt cgtgcggcag      840

acccctaccc agcacttcaa gaatcagttc cccgccctgc actgggagca cgaactgggc      900

ctggccttca ccaagaacag aatgaactac accaacaagt ttctgctgat ccccgagagc      960

ggcgactact tcatctacag ccaagtgacc ttccggggca tgaccagcga gtgcagcgag     1020

atcagacagg ccggcagacc taacaagccc gacagcatca ccgtcgtgat caccaaagtg     1080

accgacagct accccgagcc cacccagctg ctgatgggca ccaagagcgt gtgcgaagtg     1140

ggcagcaact ggttccagcc catctacctg ggcgccatgt ttagtctgca agagggcgac     1200

aagctgatgg tcaacgtgtc cgacatcagc ctggtggatt acaccaaaga ggacaagacc     1260

ttcttcggcg cctttctgct ctga                                            1284


<210>  9
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9

Met Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp Arg Ala Gln Gly Glu 
225                 230                 235                 240 


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
                245                 250                 255     


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
            260                 265                 270         


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
        275                 280                 285             


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
    290                 295                 300                 


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
305                 310                 315                 320 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
                325                 330                 335     


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
            340                 345                 350         


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
        355                 360                 365             


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
    370                 375                 380                 


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
385                 390                 395                 400 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
                405                 410                 415     


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
            420                 425         


<210>  10
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10
atgtctaagt acggccctcc ctgccctagc tgccctgccc ctgaatttct gggcggaccc       60

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa      120

gtgacctgcg tggtggtgga tgtgtcccag gaagatcccg aggtgcagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgag cggcaaagag      300

tacaagtgca aggtgtccag caagggcctg cccagcagca tcgagaaaac catcagcaac      360

gccaccggcc agcccaggga accccaggtg tacacactgc cccctagcca ggaagagatg      420

accaagaacc aggtgtccct gacctgtctc gtgaagggct tctacccctc cgatatcgcc      480

gtggaatggg agagcaacgg ccagcctgag aacaactaca agaccacccc cccagtgctg      540

gacagcgacg gctcattctt cctgtacagc agactgaccg tggacaagag cagctggcag      600

gaaggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctgt ctctgagcct gggcaagatc gagggccgga tggatcaggt gtcacacaga      720

tacccccgga tccagagcat caaagtgcag tttaccgagt acaagaaaga gaagggcttt      780

atcctgacca gccagaaaga ggacgagatc atgaaggtgc agaacaacag cgtgatcatc      840

aactgcgacg ggttctacct gatcagcctg aagggctact tcagtcagga agtgaacatc      900

agcctgcact accagaagga cgaggaaccc ctgttccagc tgaagaaagt gcggagcgtg      960

aacagcctga tggtggcctc tctgacctac aaggacaagg tgtacctgaa cgtgaccacc     1020

gacaacacca gcctggacga cttccacgtg aacggcggcg agctgatcct gattcaccag     1080

aaccccggcg agttctgcgt gctctga                                         1107


<210>  11
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  11

Met Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp Gln Val Ser His Arg 
225                 230                 235                 240 


Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys 
                245                 250                 255     


Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
            260                 265                 270         


Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile 
        275                 280                 285             


Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr 
    290                 295                 300                 


Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val 
305                 310                 315                 320 


Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu 
                325                 330                 335     


Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly 
            340                 345                 350         


Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
        355                 360                 365             


<210>  12
<211>  1588
<212>  DNA
<213>  Homo sapiens

<400>  12
tcccaagtag ctgggactac aggagcccac caccaccccc ggctaatttt ttgtattttt       60

agtagagacg gggtttcacc gtgttagcca agatggtctt gatcacctga cctcgtgatc      120

cacccgcctt ggcctcccaa agtgctggga ttacaggcat gagccaccgc gcccggcctc      180

cattcaagtc tttattgaat atctgctatg ttctacacac tgttctaggt gctggggatg      240

caacagggga caaaataggc aaaatccctg tccttttggg gttgacattc tagtgactct      300

tcatgtagtc tagaagaagc tcagtgaata gtgtctgtgg ttgttaccag ggacacaatg      360

acaggaacat tcttgggtag agtgagaggc ctggggaggg aagggtctct aggatggagc      420

agatgctggg cagtcttagg gagcccctcc tggcatgcac cccctcatcc ctcaggccac      480

ccccgtccct tgcaggagca ccctggggag ctgtccagag cgctgtgccg ctgtctgtgg      540

ctggaggcag agtaggtggt gtgctgggaa tgcgagtggg agaactggga tggaccgagg      600

ggaggcgggt gaggaggggg gcaaccaccc aacacccacc agctgctttc agtgttctgg      660

gtccaggtgc tcctggctgg ccttgtggtc cccctcctgc ttggggccac cctgacctac      720

acataccgcc actgctggcc tcacaagccc ctggttactg cagatgaagc tgggatggag      780

gctctgaccc caccaccggc cacccatctg tcacccttgg acagcgccca cacccttcta      840

gcacctcctg acagcagtga gaagatctgc accgtccagt tggtgggtaa cagctggacc      900

cctggctacc ccgagaccca ggaggcgctc tgcccgcagg tgacatggtc ctgggaccag      960

ttgcccagca gagctcttgg ccccgctgct gcgcccacac tctcgccaga gtccccagcc     1020

ggctcgccag ccatgatgct gcagccgggc ccgcagctct acgacgtgat ggacgcggtc     1080

ccagcgcggc gctggaagga gttcgtgcgc acgctggggc tgcgcgaggc agagatcgaa     1140

gccgtggagg tggagatcgg ccgcttccga gaccagcagt acgagatgct caagcgctgg     1200

cgccagcagc agcccgcggg cctcggagcc gtttacgcgg ccctggagcg catggggctg     1260

gacggctgcg tggaagactt gcgcagccgc ctgcagcgcg gcccgtgaca cggcgcccac     1320

ttgccaccta ggcgctctgg tggcccttgc agaagcccta agtacggtta cttatgcgtg     1380

tagacatttt atgtcactta ttaagccgct ggcacggccc tgcgtagcag caccagccgg     1440

ccccacccct gctcgcccct atcgctccag ccaaggcgaa gaagcacgaa cgaatgtcga     1500

gagggggtga agacatttct caacttctcg gccggagttt ggctgagatc gcggtattaa     1560

atctgtgaaa gaaaacaaaa caaaacaa                                        1588


<210>  13
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr Pro Pro Pro Ser Leu Ala Gly Ala Pro Trp Gly 
            180                 185                 190         


Ala Val Gln Ser Ala Val Pro Leu Ser Val Ala Gly Gly Arg Val Gly 
        195                 200                 205             


Val Phe Trp Val Gln Val Leu Leu Ala Gly Leu Val Val Pro Leu Leu 
    210                 215                 220                 


Leu Gly Ala Thr Leu Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys 
225                 230                 235                 240 


Pro Leu Val Thr Ala Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro 
                245                 250                 255     


Pro Ala Thr His Leu Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala 
            260                 265                 270         


Pro Pro Asp Ser Ser Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn 
        275                 280                 285             


Ser Trp Thr Pro Gly Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln 
    290                 295                 300                 


Val Thr Trp Ser Trp Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala 
305                 310                 315                 320 


Ala Ala Pro Thr Leu Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met 
                325                 330                 335     


Met Leu Gln Pro Gly Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro 
            340                 345                 350         


Ala Arg Arg Trp Lys Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala 
        355                 360                 365             


Glu Ile Glu Ala Val Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln 
    370                 375                 380                 


Tyr Glu Met Leu Lys Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly 
385                 390                 395                 400 


Ala Val Tyr Ala Ala Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu 
                405                 410                 415     


Asp Leu Arg Ser Arg Leu Gln Arg Gly Pro 
            420                 425     


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  14
ctgccacggc acagtcattg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  15
gccagttcct ccagatatcc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  16
ccacgctctt ctgtctactg                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  17
gccatagaac tgatgagagg g                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  18
ctactgctga ccttgtctct g                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  19
agtaaggcca tgtagggtcg                                                   20


<210>  20
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  20
ctgcggcatg ttctggattt gact                                              24


<210>  21
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  21
agtccaccac agttgctgac tcat                                              24


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22
gacacagtag agtgtcgcat g                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  23
aagcatgctc tgtggagctg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24
aaggccaacc gtgaaaagat                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25
gtggtacgac cagaggcata c                                                 21


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  26

Gly Gly Gly Gly Ser 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27

Gly Gly Gly Gly Ser 
1               5   


<210>  28
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  29
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  30
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30

Glu Ala Ala Ala Lys 
1               5   


<210>  31
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  31

Ala Glu Ala Ala Ala Lys Ala 
1               5           


<210>  32
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  32

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  33
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  33

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  34

Pro Ala Pro Ala Pro 
1               5   


<210>  35
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  35

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  36
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  36

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  37
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  37

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  38
<211>  852
<212>  DNA
<213>  Homo sapiens

<400>  38
atggagcctc ctggagactg ggggcctcct ccctggagat ccacccccaa aaccgacgtc       60

ttgaggctgg tgctgtatct caccttcctg ggagccccct gctacgcccc agctctgccg      120

tcctgcaagg aggacgagta cccagtgggc tccgagtgct gccccaagtg cagtccaggt      180

tatcgtgtga aggaggcctg cggggagctg acgggcacag tgtgtgaacc ctgccctcca      240

ggcacctaca ttgcccacct caatggccta agcaagtgtc tgcagtgcca aatgtgtgac      300

ccagccatgg gcctgcgcgc gagccggaac tgctccagga cagagaacgc cgtgtgtggc      360

tgcagcccag gccacttctg catcgtccag gacggggacc actgcgccgc gtgccgcgct      420

tacgccacct ccagcccggg ccagagggtg cagaagggag gcaccgagag tcaggacacc      480

ctgtgtcaga actgcccccc ggggaccttc tctcccaatg ggaccctgga ggaatgtcag      540

caccagacca agtgcagctg gctggtgacg aaggccggag ctgggaccag cagctcccac      600

tgggtatggt ggtttctctc agggagcctc gtcatcgtca ttgtttgctc cacagttggc      660

ctaatcatat gtgtgaaaag aagaaagcca aggggtgatg tagtcaaggt gatcgtctcc      720

gtccagcgga aaagacagga ggcagaaggt gaggccacag tcattgaggc cctgcaggcc      780

cctccggacg tcaccacggt ggccgtggag gagacaatac cctcattcac ggggaggagc      840

ccaaaccatt aa                                                          852


<210>  39
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  40
<211>  4900
<212>  DNA
<213>  Homo sapiens

<400>  40
taaagtcatc aaaacaacgt tatatcctgt gtgaaatgct gcagtcagga tgccttgtgg       60

tttgagtgcc ttgatcatgt gccctaaggg gatggtggcg gtggtggtgg ccgtggatga      120

cggagactct caggccttgg caggtgcgtc tttcagttcc cctcacactt cgggttcctc      180

ggggaggagg ggctggaacc ctagcccatc gtcaggacaa agatgctcag gctgctcttg      240

gctctcaact tattcccttc aattcaagta acaggaaaca agattttggt gaagcagtcg      300

cccatgcttg tagcgtacga caatgcggtc aaccttagct gcaagtattc ctacaatctc      360

ttctcaaggg agttccgggc atcccttcac aaaggactgg atagtgctgt ggaagtctgt      420

gttgtatatg ggaattactc ccagcagctt caggtttact caaaaacggg gttcaactgt      480

gatgggaaat tgggcaatga atcagtgaca ttctacctcc agaatttgta tgttaaccaa      540

acagatattt acttctgcaa aattgaagtt atgtatcctc ctccttacct agacaatgag      600

aagagcaatg gaaccattat ccatgtgaaa gggaaacacc tttgtccaag tcccctattt      660

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      720

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc      780

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac      840

cagccctatg ccccaccacg cgacttcgca gcctatcgct cctgacacgg acgcctatcc      900

agaagccagc cggctggcag cccccatctg ctcaatatca ctgctctgga taggaaatga      960

ccgccatctc cagccggcca cctcaggccc ctgttgggcc accaatgcca atttttctcg     1020

agtgactaga ccaaatatca agatcatttt gagactctga aatgaagtaa aagagatttc     1080

ctgtgacagg ccaagtctta cagtgccatg gcccacattc caacttacca tgtacttagt     1140

gacttgactg agaagttagg gtagaaaaca aaaagggagt ggattctggg agcctcttcc     1200

ctttctcact cacctgcaca tctcagtcaa gcaaagtgtg gtatccacag acattttagt     1260

tgcagaagaa aggctaggaa atcattcctt ttggttaaat gggtgtttaa tcttttggtt     1320

agtgggttaa acggggtaag ttagagtagg gggagggata ggaagacata tttaaaaacc     1380

attaaaacac tgtctcccac tcatgaaatg agccacgtag ttcctattta atgctgtttt     1440

cctttagttt agaaatacat agacattgtc ttttatgaat tctgatcata tttagtcatt     1500

ttgaccaaat gagggatttg gtcaaatgag ggattccctc aaagcaatat caggtaaacc     1560

aagttgcttt cctcactccc tgtcatgaga cttcagtgtt aatgttcaca atatactttc     1620

gaaagaataa aatagttctc ctacatgaag aaagaatatg tcaggaaata aggtcacttt     1680

atgtcaaaat tatttgagta ctatgggacc tggcgcagtg gctcatgctt gtaatcccag     1740

cactttggga ggccgaggtg ggcagatcac ttgagatcag gaccagcctg gtcaagatgg     1800

tgaaactccg tctgtactaa aaatacaaaa tttagcttgg cctggtggca ggcacctgta     1860

atcccagctg cccaagaggc tgaggcatga gaatcgcttg aacctggcag gcggaggttg     1920

cagtgagccg agatagtgcc acagctctcc agcctgggcg acagagtgag actccatctc     1980

aaacaacaac aacaacaaca acaacaacaa caaaccacaa aattatttga gtactgtgaa     2040

ggattatttg tctaacagtt cattccaatc agaccaggta ggagctttcc tgtttcatat     2100

gtttcagggt tgcacagttg gtctctttaa tgtcggtgtg gagatccaaa gtgggttgtg     2160

gaaagagcgt ccataggaga agtgagaata ctgtgaaaaa gggatgttag cattcattag     2220

agtatgagga tgagtcccaa gaaggttctt tggaaggagg acgaatagaa tggagtaatg     2280

aaattcttgc catgtgctga ggagatagcc agcattaggt gacaatcttc cagaagtggt     2340

caggcagaag gtgccctggt gagagctcct ttacagggac tttatgtggt ttagggctca     2400

gagctccaaa actctgggct cagctgctcc tgtaccttgg aggtccattc acatgggaaa     2460

gtattttgga atgtgtcttt tgaagagagc atcagagttc ttaagggact gggtaaggcc     2520

tgaccctgaa atgaccatgg atatttttct acctacagtt tgagtcaact agaatatgcc     2580

tggggacctt gaagaatggc ccttcagtgg ccctcaccat ttgttcatgc ttcagttaat     2640

tcaggtgttg aaggagctta ggttttagag gcacgtagac ttggttcaag tctcgttagt     2700

agttgaatag cctcaggcaa gtcactgccc acctaagatg atggttcttc aactataaaa     2760

tggagataat ggttacaaat gtctcttcct atagtataat ctccataagg gcatggccca     2820

agtctgtctt tgactctgcc tatccctgac atttagtagc atgcccgaca tacaatgtta     2880

gctattggta ttattgccat atagataaat tatgtataaa aattaaactg ggcaatagcc     2940

taagaagggg ggaatattgt aacacaaatt taaacccact acgcagggat gaggtgctat     3000

aatatgagga ccttttaact tccatcattt tcctgtttct tgaaatagtt tatcttgtaa     3060

tgaaatataa ggcacctccc acttttatgt atagaaagag gtcttttaat ttttttttaa     3120

tgtgagaagg aagggaggag taggaatctt gagattccag atcgaaaata ctgtactttg     3180

gttgattttt aagtgggctt ccattccatg gatttaatca gtcccaagaa gatcaaactc     3240

agcagtactt gggtgctgaa gaactgttgg atttaccctg gcacgtgtgc cacttgccag     3300

cttcttgggc acacagagtt cttcaatcca agttatcaga ttgtatttga aaatgacaga     3360

gctggagagt tttttgaaat ggcagtggca aataaataaa tacttttttt taaatggaaa     3420

gacttgatct atggtaataa atgattttgt tttctgactg gaaaaatagg cctactaaag     3480

atgaatcaca cttgagatgt ttcttactca ctctgcacag aaacaaagaa gaaatgttat     3540

acagggaagt ccgttttcac tattagtatg aaccaagaaa tggttcaaaa acagtggtag     3600

gagcaatgct ttcatagttt cagatatggt agttatgaag aaaacaatgt catttgctgc     3660

tattattgta agagtcttat aattaatggt actcctataa tttttgattg tgagctcacc     3720

tatttgggtt aagcatgcca atttaaagag accaagtgta tgtacattat gttctacata     3780

ttcagtgata aaattactaa actactatat gtctgcttta aatttgtact ttaatattgt     3840

cttttggtat taagaaagat atgctttcag aatagatatg cttcgctttg gcaaggaatt     3900

tggatagaac ttgctattta aaagaggtgt ggggtaaatc cttgtataaa tctccagttt     3960

agcctttttt gaaaaagcta gactttcaaa tactaatttc acttcaagca gggtacgttt     4020

ctggtttgtt tgcttgactt cagtcacaat ttcttatcag accaatggct gacctctttg     4080

agatgtcagg ctaggcttac ctatgtgttc tgtgtcatgt gaatgctgag aagtttgaca     4140

gagatccaac ttcagccttg accccatcag tccctcgggt taactaactg agccaccggt     4200

cctcatggct attttaatga gggtattgat ggttaaatgc atgtctgatc ccttatccca     4260

gccatttgca ctgccagctg ggaactatac cagacctgga tactgatccc aaagtgttaa     4320

attcaactac atgctggaga ttagagatgg tgccaataaa ggacccagaa ccaggatctt     4380

gattgctata gacttattaa taatccaggt caaagagagt gacacacact ctctcaagac     4440

ctggggtgag ggagtctgtg ttatctgcaa ggccatttga ggctcagaaa gtctctcttt     4500

cctatagata tatgcatact ttctgacata taggaatgta tcaggaatac tcaaccatca     4560

caggcatgtt cctacctcag ggcctttaca tgtcctgttt actctgtcta gaatgtcctt     4620

ctgtagatga cctggcttgc ctcgtcaccc ttcaggtcct tgctcaagtg tcatcttctc     4680

ccctagttaa actaccccac accctgtctg ctttccttgc ttatttttct ccatagcatt     4740

ttaccatctc ttacattaga catttttctt atttatttgt agtttataag cttcatgagg     4800

caagtaactt tgctttgttt cttgctgtat ctccagtgcc cagagcagtg cctggtatat     4860

aataaatatt tattgactga gtgaaaaaaa aaaaaaaaaa                           4900


<210>  41
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  42
<211>  1906
<212>  DNA
<213>  Homo sapiens

<400>  42
ccaagtcaca tgattcagga ttcaggggga gaatccttct tggaacagag atgggcccag       60

aactgaatca gatgaagaga gataaggtgt gatgtgggga agactatata aagaatggac      120

ccagggctgc agcaagcact caacggaatg gcccctcctg gagacacagc catgcatgtg      180

ccggcgggct ccgtggccag ccacctgggg accacgagcc gcagctattt ctatttgacc      240

acagccactc tggctctgtg ccttgtcttc acggtggcca ctattatggt gttggtcgtt      300

cagaggacgg actccattcc caactcacct gacaacgtcc ccctcaaagg aggaaattgc      360

tcagaagacc tcttatgtat cctgaaaaga gctccattca agaagtcatg ggcctacctc      420

caagtggcaa agcatctaaa caaaaccaag ttgtcttgga acaaagatgg cattctccat      480

ggagtcagat atcaggatgg gaatctggtg atccaattcc ctggtttgta cttcatcatt      540

tgccaactgc agtttcttgt acaatgccca aataattctg tcgatctgaa gttggagctt      600

ctcatcaaca agcatatcaa aaaacaggcc ctggtgacag tgtgtgagtc tggaatgcaa      660

acgaaacacg tataccagaa tctctctcaa ttcttgctgg attacctgca ggtcaacacc      720

accatatcag tcaatgtgga tacattccag tacatagata caagcacctt tcctcttgag      780

aatgtgttgt ccatcttctt atacagtaat tcagactgaa cagtttctct tggccttcag      840

gaagaaagcg cctctctacc atacagtatt tcatccctcc aaacacttgg gcaaaaagaa      900

aactttagac caagacaaac tacacagggt attaaatagt atacttctcc ttctgtctct      960

tggaaagata cagctccagg gttaaaaaga gagtttttag tgaagtatct ttcagatagc     1020

aggcagggaa gcaatgtagt gtggtgggca gagccccaca cagaatcaga agggatgaat     1080

ggatgtccca gcccaaccac taattcactg tatggtcttg atctatttct tctgttttga     1140

gagcctccag ttaaaatggg gcttcagtac cagagcagct agcaactctg ccctaatggg     1200

aaatgaaggg gagctgggtg tgagtgttta cactgtgccc ttcacgggat acttctttta     1260

tctgcagatg gcctaatgct tagttgtcca agtcgcgatc aaggactctc tcacacagga     1320

aacttcccta tactggcaga tacacttgtg actgaaccat gcccagttta tgcctgtctg     1380

actgtcactc tggcactagg aggctgatct tgtactccat atgaccccac ccctaggaac     1440

ccccagggaa aaccaggctc ggacagcccc ctgttcctga gatggaaagc acaaatttaa     1500

tacaccacca caatggaaaa caagttcaaa gacttttact tacagatcct ggacagaaag     1560

ggcataatga gtctgaaggg cagtcctcct tctccaggtt acatgaggca ggaataagaa     1620

gtcagacaga gacagcaaga cagttaacaa cgtaggtaaa gaaatagggt gtggtcactc     1680

tcaattcact ggcaaatgcc tgaatggtct gtctgaagga agcaacagag aagtggggaa     1740

tccagtctgc taggcaggaa agatgcctct aagttcttgt ctctggccag aggtgtggta     1800

tagaaccaga aacccatatc aagggtgact aagcccggct tccggtatga gaaattaaac     1860

ttgtatacaa aatggttgcc aaggcaacat aaaattataa gaattc                    1906


<210>  43
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  44
<211>  1629
<212>  DNA
<213>  Homo sapiens

<400>  44
tttcctgggc ggggccaagg ctggggcagg ggagtcagca gaggcctcgc tcgggcgccc       60

agtggtcctg ccgcctggtc tcacctcgct atggttcgtc tgcctctgca gtgcgtcctc      120

tggggctgct tgctgaccgc tgtccatcca gaaccaccca ctgcatgcag agaaaaacag      180

tacctaataa acagtcagtg ctgttctttg tgccagccag gacagaaact ggtgagtgac      240

tgcacagagt tcactgaaac ggaatgcctt ccttgcggtg aaagcgaatt cctagacacc      300

tggaacagag agacacactg ccaccagcac aaatactgcg accccaacct agggcttcgg      360

gtccagcaga agggcacctc agaaacagac accatctgca cctgtgaaga aggctggcac      420

tgtacgagtg aggcctgtga gagctgtgtc ctgcaccgct catgctcgcc cggctttggg      480

gtcaagcaga ttgctacagg ggtttctgat accatctgcg agccctgccc agtcggcttc      540

ttctccaatg tgtcatctgc tttcgaaaaa tgtcaccctt ggacaagctg tgagaccaaa      600

gacctggttg tgcaacaggc aggcacaaac aagactgatg ttgtctgtgg tccccaggat      660

cggctgagag ccctggtggt gatccccatc atcttcggga tcctgtttgc catcctcttg      720

gtgctggtct ttatcaaaaa ggtggccaag aagccaacca ataaggcccc ccaccccaag      780

caggaacccc aggagatcaa ttttcccgac gatcttcctg gctccaacac tgctgctcca      840

gtgcaggaga ctttacatgg atgccaaccg gtcacccagg aggatggcaa agagagtcgc      900

atctcagtgc aggagagaca gtgaggctgc acccacccag gagtgtggcc acgtgggcaa      960

acaggcagtt ggccagagag cctggtgctg ctgctgctgt ggcgtgaggg tgaggggctg     1020

gcactgactg ggcatagctc cccgcttctg cctgcacccc tgcagtttga gacaggagac     1080

ctggcactgg atgcagaaac agttcacctt gaagaacctc tcacttcacc ctggagccca     1140

tccagtctcc caacttgtat taaagacaga ggcagaagtt tggtggtggt ggtgttgggg     1200

tatggtttag taatatccac cagaccttcc gatccagcag tttggtgccc agagaggcat     1260

catggtggct tccctgcgcc caggaagcca tatacacaga tgcccattgc agcattgttt     1320

gtgatagtga acaactggaa gctgcttaac tgtccatcag caggagactg gctaaataaa     1380

attagaatat atttatacaa cagaatctca aaaacactgt tgagtaagga aaaaaaggca     1440

tgctgctgaa tgatgggtat ggaacttttt aaaaaagtac atgcttttat gtatgtatat     1500

tgcctatgga tatatgtata aatacaatat gcatcatata ttgatataac aagggttctg     1560

gaagggtaca cagaaaaccc acagctcgaa gagtggtgac gtctggggtg gggaagaagg     1620

gtctggggg                                                             1629


<210>  45
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  46
<211>  913
<212>  DNA
<213>  Homo sapiens

<400>  46
ccagagaggg gcaggctggt cccctgacag gttgaagcaa gtagacgccc aggagccccg       60

ggagggggct gcagtttcct tccttccttc tcggcagcgc tccgcgcccc catcgcccct      120

cctgcgctag cggaggtgat cgccgcggcg atgccggagg agggttcggg ctgctcggtg      180

cggcgcaggc cctatgggtg cgtcctgcgg gctgctttgg tcccattggt cgcgggcttg      240

gtgatctgcc tcgtggtgtg catccagcgc ttcgcacagg ctcagcagca gctgccgctc      300

gagtcacttg ggtgggacgt agctgagctg cagctgaatc acacaggacc tcagcaggac      360

cccaggctat actggcaggg gggcccagca ctgggccgct ccttcctgca tggaccagag      420

ctggacaagg ggcagctacg tatccatcgt gatggcatct acatggtaca catccaggtg      480

acgctggcca tctgctcctc cacgacggcc tccaggcacc accccaccac cctggccgtg      540

ggaatctgct ctcccgcctc ccgtagcatc agcctgctgc gtctcagctt ccaccaaggt      600

tgtaccattg cctcccagcg cctgacgccc ctggcccgag gggacacact ctgcaccaac      660

ctcactggga cacttttgcc ttcccgaaac actgatgaga ccttctttgg agtgcagtgg      720

gtgcgcccct gaccactgct gctgattagg gttttttaaa ttttatttta ttttatttaa      780

gttcaagaga aaaagtgtac acacaggggc cacccggggt tggggtggga gtgtggtggg      840

gggtagtggt ggcaggacaa gagaaggcat tgagcttttt ctttcatttt cctattaaaa      900

aatacaaaaa tca                                                         913


<210>  47
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  48
<211>  723
<212>  DNA
<213>  Homo sapiens

<400>  48
atggaggaga gtgtcgtacg gccctcagtg tttgtggtgg atggacagac cgacatccca       60

ttcacgaggc tgggacgaag ccaccggaga cagtcgtgca gtgtggcccg ggtgggtctg      120

ggtctcttgc tgttgctgat gggggccggg ctggccgtcc aaggctggtt cctcctgcag      180

ctgcactggc gtctaggaga gatggtcacc cgcctgcctg acggacctgc aggctcctgg      240

gagcagctga tacaagagcg aaggtctcac gaggtcaacc cagcagcgca tctcacaggg      300

gccaactcca gcttgaccgg cagcgggggg ccgctgttat gggagactca gctgggcctg      360

gccttcctga ggggcctcag ctaccacgat ggggcccttg tggtcaccaa agctggctac      420

tactacatct actccaaggt gcagctgggc ggtgtgggct gcccgctggg cctggccagc      480

accatcaccc acggcctcta caagcgcaca ccccgctacc ccgaggagct ggagctgttg      540

gtcagccagc agtcaccctg cggacgggcc accagcagct cccgggtctg gtgggacagc      600

agcttcctgg gtggtgtggt acacctggag gctggggagg aggtggtcgt ccgtgtgctg      660

gatgaacgcc tggttcgact gcgtgatggt acccggtctt acttcggggc tttcatggtg      720

tga                                                                    723


<210>  49
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


