               SEQUENCE LISTING

<110> GAMAMABS PHARMA
      INSTITUT CURIE

<120> AMHRII-binding compounds for preventing or treating cancers

<130> PR77465

<140> EP17305445.3
<141> 2017-04-14

<150> EP17305445
<151> 2017-04-14

<160> 74

<170> BiSSAP 1.3.6

<210> 1
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3C_23 VL without leader" <223> "3C_23 VL without leader

<220> 
<223> 3C_23 VL without leader

<220> 
<223> 3C_23 VL without leader

<220> 
<221> CDS
<222> 1..318

<400> 1
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga     48
gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc     96
gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg acc tac    144
cca acc tcc tcc ctg gaa tcc ggg gtg ccc agc aga ttc tca ggc agt    192
ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac    240
gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca    288
ttc ggc ggc ggc acc aag gtg gag atc aag                            318

<210> 2
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Construct <223> Synthetic Construct
      [CDS]:1..318 from SEQ ID NO 1

<220> 
<223> Synthetic Construct

<220> 
<223> Synthetic Construct

<400> 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 3
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3C_23 VH without leader" <223> "3C_23 VH without leader

<220> 
<223> 3C_23 VH without leader

<220> 
<223> 3C_23 VH without leader

<220> 
<221> CDS
<222> 1..345

<400> 3
cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc     48
tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac     96
cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg    144
ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc    192
cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac    240
atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt    288
aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc    336
gtc tcg agc                                                        345

<210> 4
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Construct <223> Synthetic Construct
      [CDS]:1..345 from SEQ ID NO 3

<220> 
<223> Synthetic Construct

<220> 
<223> Synthetic Construct

<400> 4
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 5
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3C_23K VL without leader" <223> "3C_23K VL without leader

<220> 
<223> 3C_23K VL without leader

<220> 
<223> 3C_23K VL without leader

<220> 
<221> CDS
<222> 1..318

<400> 5
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga     48
gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc     96
gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg acc tac    144
cca acc tcc tcc ctg aaa tcc ggg gtg ccc agc aga ttc tca ggc agt    192
ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac    240
gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca    288
ttc ggc ggc ggc acc aag gtg gag atc aag                            318

<210> 6
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Construct <223> Synthetic Construct
      [CDS]:1..318 from SEQ ID NO 5

<220> 
<223> Synthetic Construct

<220> 
<223> Synthetic Construct

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 7
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3C_23K VH without leader" <223> "3C_23K VH without leader

<220> 
<223> 3C_23K VH without leader

<220> 
<223> 3C_23K VH without leader

<220> 
<221> CDS
<222> 1..345

<400> 7
cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc     48
tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac     96
cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg    144
ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc    192
cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac    240
atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt    288
aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc    336
gtc tcg agc                                                        345

<210> 8
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Construct <223> Synthetic Construct
      [CDS]:1..345 from SEQ ID NO 7

<220> 
<223> Synthetic Construct

<220> 
<223> Synthetic Construct

<400> 8
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 9
<211> 639
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3C_23 light chain without leader" <223> "3C_23 light chain
      without leader

<220> 
<223> 3C_23 light chain without leader

<220> 
<223> 3C_23 light chain without leader

<220> 
<221> CDS
<222> 1..639

<400> 9
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga     48
gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc     96
gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg acc tac    144
cca acc tcc tcc ctg gaa tcc ggg gtg ccc agc aga ttc tca ggc agt    192
ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac    240
gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca    288
ttc ggc ggc ggc acc aag gtg gag atc aag cgg acc gtc gcc gca cca    336
agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act    384
gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa    432
gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag    480
agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc    528
acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc    576
tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc    624
aac agg gga gag tgt                                                639

<210> 10
<211> 213
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Construct <223> Synthetic Construct
      [CDS]:1..639 from SEQ ID NO 9

<220> 
<223> Synthetic Construct

<220> 
<223> Synthetic Construct

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210> 11
<211> 1335
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3C_23 heavy chain without leader" <223> "3C_23 heavy chain
      without leader

<220> 
<223> 3C_23 heavy chain without leader

<220> 
<223> 3C_23 heavy chain without leader

<220> 
<221> CDS
<222> 1..1335

<400> 11
cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc      48
tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac      96
cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg     144
ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc     192
cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac     240
atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt     288
aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc     336
gtc tcg agc gcc agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc     384
tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc     432
aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc     480
ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga     528
ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc     576
acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag     624
gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc     672
cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc     720
ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag     768
gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag     816
ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag     864
ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc     912
acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag     960
gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa    1008
gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc    1056
cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa    1104
ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag    1152
ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc    1200
tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag    1248
cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac    1296
cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa                1335

<210> 12
<211> 445
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Construct <223> Synthetic Construct
      [CDS]:1..1335 from SEQ ID NO 11

<220> 
<223> Synthetic Construct

<220> 
<223> Synthetic Construct

<400> 12
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210> 13
<211> 639
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3C_23K light chain without leader" <223> "3C_23K light chain
      without leader

<220> 
<223> 3C_23K light chain without leader

<220> 
<223> 3C_23K light chain without leader

<220> 
<221> CDS
<222> 1..639

<400> 13
gac atc cag atg aca cag tcc cca tct acc ctg tct gct tcc gtg gga     48
gat cgg gtg act atc acc tgc aga gca agc tcc tcc gtg agg tac atc     96
gct tgg tac cag cag aag cca gga aag gcc cca aag ctg ctg acc tac    144
cca acc tcc tcc ctg aaa tcc ggg gtg ccc agc aga ttc tca ggc agt    192
ggc tcc ggc acc gaa ttc acc ctg acc atc agc tca ctg cag cct gac    240
gac ttc gca acc tac tac tgt ctg cag tgg agt agc tac cct tgg aca    288
ttc ggc ggc ggc acc aag gtg gag atc aag cgg acc gtc gcc gca cca    336
agt gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga act    384
gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc aaa    432
gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag gag    480
agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc agc    528
acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac gcc    576
tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc ttc    624
aac agg gga gag tgt                                                639

<210> 14
<211> 213
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Construct <223> Synthetic Construct
      [CDS]:1..639 from SEQ ID NO 13

<220> 
<223> Synthetic Construct

<220> 
<223> Synthetic Construct

<400> 14
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210> 15
<211> 1335
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3C_23K heavy chain without leader" <223> "3C_23K heavy chain
      without leader

<220> 
<223> 3C_23K heavy chain without leader

<220> 
<223> 3C_23K heavy chain without leader

<220> 
<221> CDS
<222> 1..1335

<400> 15
cag gtg cgg ctg gtg cag agc ggg gcc gag gtg aag aag cct gga gcc      48
tca gtg aag gtg agt tgc aag gcc tcc ggt tac acc ttc acc agc tac      96
cac atc cac tgg gtc aga cag gct ccc ggc cag aga ctg gag tgg atg     144
ggc tgg atc tac cct gga gat gac tcc acc aag tac tcc cag aag ttc     192
cag ggt cgc gtg acc att acc agg gac acc agc gcc tcc act gcc tac     240
atg gag ctg tct tcc ctg aga tct gag gat acc gca gtc tac tac tgt     288
aca cgg ggg gac cgc ttt gct tac tgg ggg cag ggc act ctg gtg acc     336
gtc tcg agc gcc agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc     384
tcc tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc     432
aag gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc     480
ctg acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga     528
ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc     576
acc cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag     624
gtg gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc     672
cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc     720
ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag     768
gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag     816
ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag     864
ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc     912
acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag     960
gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa    1008
gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc    1056
cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa    1104
ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag    1152
ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc    1200
tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag    1248
cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac    1296
cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa                1335

<210> 16
<211> 445
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Construct <223> Synthetic Construct
      [CDS]:1..1335 from SEQ ID NO 15

<220> 
<223> Synthetic Construct

<220> 
<223> Synthetic Construct

<400> 16
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210> 17
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> signal peptide " <223> signal peptide

<220> 
<223> signal peptide

<220> 
<223> signal peptide

<400> 17
Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Thr Ala Val Glu 
1               5                   10                  15      
Ala 
    

<210> 18
<211> 556
<212> PRT
<213> Homo sapiens


<220> 
<223> Human AMHR-II lacking the signal peptide SEQ ID NO: 17" <223>
      Human AMHR-II lacking the signal peptide SEQ ID NO: 17

<220> 
<223> Human AMHR-II lacking the signal peptide SEQ ID NO: 17

<220> 
<223> Human AMHR-II lacking the signal peptide SEQ ID NO: 17

<400> 18
Pro Pro Asn Arg Arg Thr Cys Val Phe Phe Glu Ala Pro Gly Val Arg 
1               5                   10                  15      
Gly Ser Thr Lys Thr Leu Gly Glu Leu Leu Asp Thr Gly Thr Glu Leu 
            20                  25                  30          
Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile Trp 
        35                  40                  45              
Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg Asp 
    50                  55                  60                  
Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro Arg 
65                  70                  75                  80  
Ala His Pro Ser Pro Gly Ser Thr Leu Phe Thr Cys Ser Cys Gly Thr 
                85                  90                  95      
Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser Pro 
            100                 105                 110         
Gly Thr Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser Ile 
        115                 120                 125             
Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu Leu 
    130                 135                 140                 
Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg Val 
145                 150                 155                 160 
Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp Trp 
                165                 170                 175     
Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val Ile 
            180                 185                 190         
Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly Lys 
        195                 200                 205             
Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe Gln 
    210                 215                 220                 
Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His Ile 
225                 230                 235                 240 
Val Arg Phe Ile Thr Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu Ser 
                245                 250                 255     
Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys His 
            260                 265                 270         
Tyr Leu Thr Gln Tyr Thr Ser Asp Trp Gly Ser Ser Leu Arg Met Ala 
        275                 280                 285             
Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp Gln 
    290                 295                 300                 
Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser Gln 
305                 310                 315                 320 
Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu Gly 
                325                 330                 335     
Leu Ala Leu Val Leu Pro Gly Leu Thr Gln Pro Pro Ala Trp Thr Pro 
            340                 345                 350         
Thr Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Thr Gln Arg 
        355                 360                 365             
Tyr Met Ala Pro Glu Leu Leu Asp Lys Thr Leu Asp Leu Gln Asp Trp 
    370                 375                 380                 
Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu Leu 
385                 390                 395                 400 
Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Asp Ser Ser Pro 
                405                 410                 415     
Pro Pro Phe Gln Leu Ala Tyr Glu Ala Glu Leu Gly Asn Thr Pro Thr 
            420                 425                 430         
Ser Asp Glu Leu Trp Ala Leu Ala Val Gln Glu Arg Arg Arg Pro Tyr 
        435                 440                 445             
Ile Pro Ser Thr Trp Arg Cys Phe Ala Thr Asp Pro Asp Gly Leu Arg 
    450                 455                 460                 
Glu Leu Leu Glu Asp Cys Trp Asp Ala Asp Pro Glu Ala Arg Leu Thr 
465                 470                 475                 480 
Ala Glu Cys Val Gln Gln Arg Leu Ala Ala Leu Ala His Pro Gln Glu 
                485                 490                 495     
Ser His Pro Phe Pro Glu Ser Cys Pro Arg Gly Cys Pro Pro Leu Cys 
            500                 505                 510         
Pro Glu Asp Cys Thr Ser Ile Pro Ala Pro Thr Ile Leu Pro Cys Arg 
        515                 520                 525             
Pro Gln Arg Ser Ala Cys His Phe Ser Val Gln Gln Gly Pro Cys Ser 
    530                 535                 540                 
Arg Asn Pro Gln Pro Ala Cys Thr Leu Ser Pro Val 
545                 550                 555     

<210> 19
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 3C23K/3C23 <223> 3C23K/3C23

<220> 
<223> 3C23K/3C23

<220> 
<223> 3C23K/3C23

<400> 19
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 20
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 3C23KR/6B78 <223> 3C23KR/6B78

<220> 
<223> 3C23KR/6B78

<220> 
<223> 3C23KR/6B78

<400> 20
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 21
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5B42 <223> 5B42

<220> 
<223> 5B42

<220> 
<223> 5B42

<400> 21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Ala Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 22
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> K4D-24/6C59 <223> K4D-24/6C59

<220> 
<223> K4D-24/6C59

<220> 
<223> K4D-24/6C59

<400> 22
Arg Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 23
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> K4D-20 <223> K4D-20

<220> 
<223> K4D-20

<220> 
<223> K4D-20

<400> 23
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 24
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> K4A-12 <223> K4A-12

<220> 
<223> K4A-12

<220> 
<223> K4A-12

<400> 24
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 25
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> K5D05 <223> K5D05

<220> 
<223> K5D05

<220> 
<223> K5D05

<400> 25
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 26
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> K5D-14 <223> K5D-14

<220> 
<223> K5D-14

<220> 
<223> K5D-14

<400> 26
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 27
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> K4D-123 <223> K4D-123

<220> 
<223> K4D-123

<220> 
<223> K4D-123

<400> 27
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 28
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> K4D-127/6C07 <223> K4D-127/6C07

<220> 
<223> K4D-127/6C07

<220> 
<223> K4D-127/6C07

<400> 28
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Thr Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 29
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5C14 <223> 5C14

<220> 
<223> 5C14

<220> 
<223> 5C14

<400> 29
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Phe Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 30
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5C26 <223> 5C26

<220> 
<223> 5C26

<220> 
<223> 5C26

<400> 30
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Met Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 31
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5C27 <223> 5C27

<220> 
<223> 5C27

<220> 
<223> 5C27

<400> 31
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 32
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5C60 <223> 5C60

<220> 
<223> 5C60

<220> 
<223> 5C60

<400> 32
Gln Val Arg Leu Val Gln Ser Gly Ala Lys Val Arg Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 33
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6C13 <223> 6C13

<220> 
<223> 6C13

<220> 
<223> 6C13

<400> 33
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Glu Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 34
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6C18 <223> 6C18

<220> 
<223> 6C18

<220> 
<223> 6C18

<400> 34
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 35
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6C54 <223> 6C54

<220> 
<223> 6C54

<220> 
<223> 6C54

<400> 35
Gln Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
His Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 36
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> 3C23K <223> 3C23K

<220> 
<223> 3C23K

<220> 
<223> 3C23K

<400> 36
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 37
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-K55E <223> L-K55E

<220> 
<223> L-K55E

<220> 
<223> L-K55E

<400> 37
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 38
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-T48I, L-P50S <223> L-T48I, L-P50S

<220> 
<223> L-T48I, L-P50S

<220> 
<223> L-T48I, L-P50S

<400> 38
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              
Ser Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 39
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> LT48I, L-K55E <223> LT48I, L-K55E

<220> 
<223> LT48I, L-K55E

<220> 
<223> LT48I, L-K55E

<400> 39
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 40
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> LS27P, L-S28P <223> LS27P, L-S28P

<220> 
<223> LS27P, L-S28P

<220> 
<223> LS27P, L-S28P

<400> 40
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Pro Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 41
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-M4L, L-T20A <223> L-M4L, L-T20A

<220> 
<223> L-M4L, L-T20A

<220> 
<223> L-M4L, L-T20A

<400> 41
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 42
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-S27P <223> L-S27P

<220> 
<223> L-S27P

<220> 
<223> L-S27P

<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 43
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-M4L, L-S9P, L-R31W <223> L-M4L, L-S9P, L-R31W

<220> 
<223> L-M4L, L-S9P, L-R31W

<220> 
<223> L-M4L, L-S9P, L-R31W

<400> 43
Asp Ile Gln Leu Thr Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Trp Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 44
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-M4L <223> L-M4L

<220> 
<223> L-M4L

<220> 
<223> L-M4L

<400> 44
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 45
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-I33T <223> L-I33T

<220> 
<223> L-I33T

<220> 
<223> L-I33T

<400> 45
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Thr 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 46
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-M4L, L-K39E <223> L-M4L, L-K39E

<220> 
<223> L-M4L, L-K39E

<220> 
<223> L-M4L, L-K39E

<400> 46
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 47
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-T22P <223> L-T22P

<220> 
<223> L-T22P

<220> 
<223> L-T22P

<400> 47
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Pro Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 48
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-Y32D <223> L-Y32D

<220> 
<223> L-Y32D

<220> 
<223> L-Y32D

<400> 48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Asp Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 49
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-Q37H <223> L-Q37H

<220> 
<223> L-Q37H

<220> 
<223> L-Q37H

<400> 49
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr His Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 50
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-G97S <223> L-G97S

<220> 
<223> L-G97S

<220> 
<223> L-G97S

<400> 50
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Ser Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 51
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-S12P <223> L-S12P

<220> 
<223> L-S12P

<220> 
<223> L-S12P

<400> 51
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Pro Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 52
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-19A <223> L-19A

<220> 
<223> L-19A

<220> 
<223> L-19A

<400> 52
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 53
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-T72A <223> L-T72A

<220> 
<223> L-T72A

<220> 
<223> L-T72A

<400> 53
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 54
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-R31W <223> L-R31W

<220> 
<223> L-R31W

<220> 
<223> L-R31W

<400> 54
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Trp Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 55
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-M4L, L-M39K <223> L-M4L, L-M39K

<220> 
<223> L-M4L, L-M39K

<220> 
<223> L-M4L, L-M39K

<400> 55
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Met Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 56
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-I2N <223> L-I2N

<220> 
<223> L-I2N

<220> 
<223> L-I2N

<400> 56
Asp Asn Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 57
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-G63C, L-W91C <223> L-G63C, L-W91C

<220> 
<223> L-G63C, L-W91C

<220> 
<223> L-G63C, L-W91C

<400> 57
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Cys Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Cys Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 58
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-R31G <223> L-R31G

<220> 
<223> L-R31G

<220> 
<223> L-R31G

<400> 58
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Gly Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 59
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-I75F <223> L-I75F

<220> 
<223> L-I75F

<220> 
<223> L-I75F

<400> 59
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Phe Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 60
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-I2T <223> L-I2T

<220> 
<223> L-I2T

<220> 
<223> L-I2T

<400> 60
Asp Thr Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 61
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-I2T, L-K42R <223> L-I2T, L-K42R

<220> 
<223> L-I2T, L-K42R

<220> 
<223> L-I2T, L-K42R

<400> 61
Asp Thr Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 62
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-Y49H <223> L-Y49H

<220> 
<223> L-Y49H

<220> 
<223> L-Y49H

<400> 62
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr His 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 63
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-M4L, L-T20S, L-K39E <223> L-M4L, L-T20S, L-K39E

<220> 
<223> L-M4L, L-T20S, L-K39E

<220> 
<223> L-M4L, L-T20S, L-K39E

<400> 63
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 64
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-T69P <223> L-T69P

<220> 
<223> L-T69P

<220> 
<223> L-T69P

<400> 64
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 
            20                  25                  30          
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Thr Tyr 
        35                  40                  45              
Pro Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Pro Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     

<210> 65
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL-1 of anti-AMHRII antibody

<220> 
<223> CDRL-1 of anti-AMHRII antibody

<220> 
<221> VARIANT
<222> 4
<223> Xaa in position 4 can be S or P

<220> 
<221> VARIANT
<222> 5
<223> Xaa in position 5 can be S or P

<220> 
<221> VARIANT
<222> 7
<223> Xaa in position 7 can be R or W or G

<220> 
<221> VARIANT
<222> 8
<223> Xaa in position 8 can be T or D

<220> 
<221> VARIANT
<222> 9
<223> Waa in position 9 can be I or T

<400> 65
Arg Ala Ser Xaa Xaa Val Xaa Xaa Xaa Ala 
1               5                   10  

<210> 66
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL-2 of anti-AMHRII antibody

<220> 
<223> CDRL-2 of anti-AMHRII antibody

<220> 
<221> VARIANT
<222> 6
<223> Xaa in position 6 can be K or E

<400> 66
Pro Thr Ser Ser Leu Xaa Ser 
1               5           

<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL-3 of anti-AMHRII antibody

<220> 
<223> CDRL-3 of anti-AMHRII antibody

<400> 67
Leu Gln Trp Ser Ser Tyr Pro Trp Thr 
1               5                   

<210> 68
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH-1 of anti-AMHRII antibody

<220> 
<223> CDRH-1 of anti-AMHRII antibody

<220> 
<221> VARIANT
<222> 6
<223> Xaa in position 6 can be S or T

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 can be S or G

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 can be Y or N

<400> 68
Lys Ala Ser Gly Tyr Xaa Phe Thr Xaa Xaa His Ile His 
1               5                   10              

<210> 69
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH-2 of anti-AMHRII antibody

<220> 
<223> CDRH-2 of anti-AMHRII antibody

<220> 
<221> VARIANT
<222> 5
<223> Xaa in position 5 can be G or E

<400> 69
Trp Ile Tyr Pro Xaa Asp Asp Ser Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 70
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH-3 of anti-AMHRII antibody

<220> 
<223> CDRH-3 of anti-AMHRII antibody

<400> 70
Gly Asp Arg Phe Ala Tyr 
1               5       

<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> formard primer for AMHR2

<220> 
<223> formard primer for AMHR2

<400> 71
tctggatggc actggtgctg                                                20


<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> reverse primer for AMHR2

<220> 
<223> reverse primer for AMHR2

<400> 72
agcagggcca agatgatgct                                                20


<210> 73
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> forward primer for TBP

<220> 
<223> forward primer for TBP

<400> 73
tgcacaggag ccaagagtga a                                              21


<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> reverse primer for TBP

<220> 
<223> reverse primer for TBP

<400> 74
cacatcacag ctccccacca                                                20


