                               SEQUENCE LISTING

<110> NATIONAL TAIWAN UNIVERSITY
 
<120> GENE THERAPY FOR AADC DEFICIENCY

<130> A36-7000US1 (085143-593590)

<140> 15/951,270
<141> 2018-04-12

<150> 62/485,658
<151> 2017-04-14

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 5591
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
tgacagatct gcgcgcgatc gatctgcgcg ctcgctcgct cactgaggcc gcccgggcgt       60

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc      120

aactccatca ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctacg      180

tagccatgct ctagagcggc cgcacgcgta ctagttatta atagtaatca attacggggt      240

cattagttca tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc      300

ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag      360

taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc      420

acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg      480

gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc      540

agtacatcta cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca      600

atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca      660

atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg      720

ccccattgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc      780

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa      840

gacaccggga ccgatccagc ctccgcggat tcgaatcccg gccgggaacg gtgcattgga      900

acgcggattc cccgtgccaa gagtgacgta agtaccgcct atagagtcta taggcccaca      960

aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat actttcccta     1020

atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca ccattctaaa     1080

gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata taaatatttc     1140

tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc tacaatccag     1200

ctaccattct ggttttattt tatggttggg ataaggctgg attattctga gtccaagcta     1260

ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacagctcc tgggcaacgt     1320

gctggtctgt gtgctggccc atcactttgg caaagaattg ggattcgaac atcgattgaa     1380

ttccccgggg atccaccatg aacgcaagtg aattccgaag gagagggaag gagatggtgg     1440

attacgtggc caactacatg gaaggcattg agggacgcca ggtctaccct gacgtggagc     1500

ccgggtacct gcggccgctg atccctgccg ctgcccctca ggagccagac acgtttgagg     1560

acatcatcaa cgacgttgag aagataatca tgcctggggt gacgcactgg cacagcccct     1620

acttcttcgc ctacttcccc actgccagct cgtacccggc catgcttgcg gacatgctgt     1680

gcggggccat tggctgcatc ggcttctcct gggcggcaag cccagcatgc acagagctgg     1740

agactgtgat gatggactgg ctcgggaaga tgctggaact accaaaggca tttttgaatg     1800

agaaagctgg agaaggggga ggagtgatcc agggaagtgc cagtgaagcc accctggtgg     1860

ccctgctggc cgctcggacc aaagtgatcc atcggctgca ggcagcgtcc ccagagctca     1920

cacaggccgc tatcatggag aagctggtgg cttactcatc cgatcaggca cactcctcag     1980

tggaaagagc tgggttaatt ggtggagtga aattaaaagc catcccctca gatggcaact     2040

tcgccatgcg tgcgtctgcc ctgcaggaag ccctggagag agacaaagcg gctggcctga     2100

ttcctttctt tatggttgcc accctgggga ccacaacatg ctgctccttt gacaatctct     2160

tagaagtcgg tcctatctgc aacaaggaag acatatggct gcacgttgat gcagcctacg     2220

caggcagtgc attcatctgc cctgagttcc ggcaccttct gaatggagtg gagtttgcag     2280

attcattcaa ctttaatccc cacaaatggc tattggtgaa ttttgactgt tctgccatgt     2340

gggtgaaaaa gagaacagac ttaacgggag cctttagact ggaccccact tacctgaagc     2400

acagccatca ggattcaggg cttatcactg actaccggca ttggcagata ccactgggca     2460

gaagatttcg ctctttgaaa atgtggtttg tatttaggat gtatggagtc aaaggactgc     2520

aggcttatat ccgcaagcat gtccagctgt cccatgagtt tgagtcactg gtgcgccagg     2580

atccccgctt tgaaatctgt gtggaagtca ttctggggct tgtctgcttt cggctaaagg     2640

gttccaacaa agtgaatgaa gctcttctgc aaagaataaa cagtgccaaa aaaatccact     2700

tggttccatg tcacctcagg gacaagtttg tcctgcgctt tgccatctgt tctcgcacgg     2760

tggaatctgc ccatgtgcag cgggcctggg aacacatcaa agagctggcg gccgacgtgc     2820

tgcgagcaga gagggagtag gagtgaagcc agctgcagga atcaaaaatt gaagagagat     2880

atatctgaaa actggaataa gaagcaaata aatatcatcc tgccttcatg gaactcagct     2940

gtctgtggct tcccatgtct ttctccaaag ttatccagag ggttgtgatt ttgtctgctt     3000

agtatctcat caacaaagaa atattatttg ctaattaaaa agttaatctt catggccata     3060

gcttttattc attagctgtg atttttgttg attaaaacat tatagatttt catgttcttg     3120

cagtcatcag aagtggtagg aaagcctcac tgatatattt tccagggcaa tcaatgttca     3180

cgcaacttga aattatatct gtggtcttca aattgtcttt tgtcatgtgg ctaaatgcct     3240

aataaggaat taattcgata tcaagctatc caacacactg gtagggataa cagggtaatc     3300

tcgaggcaag cttgggcccg gtacccaatt cgccctatag tgagtcgtat tacgcgcgca     3360

gcggccgacc atggcccaac ttgtttattg cagcttataa tggttacaaa taaagcaata     3420

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     3480

aactcatcaa tgtatcttat catgtctgga tctccggaca cgtgcggacc gagcggccgc     3540

tctagagcat ggctacgtag ataagtagca tggcgggtta atcattaact acaaggaacc     3600

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     3660

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg     3720

cagatcagcg ctttaaattc agaagaactc gtcaagaagg cgatagaagg cgatgcgctg     3780

cgaatcggga gcggcgatac cgtaaagcac gaggaagcgg tcagcccatt cgccgccaag     3840

ctcttcagca atatcacggg tagccaacgc tatgtcctga tagcggtccg ccacacccag     3900

ccggccacag tcgatgaatc cagaaaagcg gccattttcc accatgatat tcggcaagca     3960

ggcatcgcca tgggtcacga cgagatcctc gccgtcgggc atgctcgcct tgagcctggc     4020

gaacagttcg gctggcgcga gcccctgatg ctcttcgtcc agatcatcct gatcgacaag     4080

accggcttcc atccgagtac gtgctcgctc gatgcgatgt ttcgcttggt ggtcgaatgg     4140

gcaggtagcc ggatcaagcg tatgcagccg ccgcattgca tcagccatga tggatacttt     4200

ctcggcagga gcaaggtgag atgacaggag atcctgcccc ggcacttcgc ccaatagcag     4260

ccagtccctt cccgcttcag tgacaacgtc gagcacagct gcgcaaggaa cgcccgtcgt     4320

ggccagccac gatagccgcg ctgcctcgtc ttgcagttca ttcagggcac cggacaggtc     4380

ggtcttgaca aaaagaaccg ggcgcccctg cgctgacagc cggaacacgg cggcatcaga     4440

gcagccgatt gtctgttgtg cccagtcata gccgaatagc ctctccaccc aagcggccgg     4500

agaacctgcg tgcaatccat cttgttcaat catgcgaaac gatcctcatc ctgtctcttg     4560

atcagatctt gatcccctgc gccatcagat ctttggcggc aagaaagcca tccagtttac     4620

tttgcagggc ttcccaacct taccagaggg cgccccagct ggcaattccg gttcgcttgc     4680

tgtccataaa accgcccagt ctagctatcg ccatgtaagc ccactgcaag ctacctgctt     4740

tctctttgcg cttgcgtttt cccttgtcca gatagcccag tagctgacat tcatccgggg     4800

tcagcaccgt ttctgcggac tggctttcta cgtgaaaagg atctaggtga agatcctttt     4860

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     4920

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     4980

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     5040

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt     5100

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     5160

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     5220

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     5280

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     5340

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     5400

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     5460

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     5520

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     5580

ttttgctcac a                                                          5591


<210> 2
<211> 3703
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
tctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt ggtcgcccgg       60

cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact aggggttcct      120

tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct agagcggccg      180

cacgcgtact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat      240

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc      300

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      360

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta      420

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      480

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      540

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      600

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      660

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      720

taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcgc      780

ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct      840

ccgcggattc gaatcccggc cgggaacggt gcattggaac gcggattccc cgtgccaaga      900

gtgacgtaag taccgcctat agagtctata ggcccacaaa aaatgctttc ttcttttaat      960

atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt cagggcaata     1020

atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga taatttctgg     1080

gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt gtaactgatg     1140

taagaggttt catattgcta atagcagcta caatccagct accattctgg ttttatttta     1200

tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct aatcatgttc     1260

atacctctta tcttcctccc acagctcctg ggcaacgtgc tggtctgtgt gctggcccat     1320

cactttggca aagaattggg attcgaacat cgattgaatt ccccggggat ccaccatgaa     1380

cgcaagtgaa ttccgaagga gagggaagga gatggtggat tacgtggcca actacatgga     1440

aggcattgag ggacgccagg tctaccctga cgtggagccc gggtacctgc ggccgctgat     1500

ccctgccgct gcccctcagg agccagacac gtttgaggac atcatcaacg acgttgagaa     1560

gataatcatg cctggggtga cgcactggca cagcccctac ttcttcgcct acttccccac     1620

tgccagctcg tacccggcca tgcttgcgga catgctgtgc ggggccattg gctgcatcgg     1680

cttctcctgg gcggcaagcc cagcatgcac agagctggag actgtgatga tggactggct     1740

cgggaagatg ctggaactac caaaggcatt tttgaatgag aaagctggag aagggggagg     1800

agtgatccag ggaagtgcca gtgaagccac cctggtggcc ctgctggccg ctcggaccaa     1860

agtgatccat cggctgcagg cagcgtcccc agagctcaca caggccgcta tcatggagaa     1920

gctggtggct tactcatccg atcaggcaca ctcctcagtg gaaagagctg ggttaattgg     1980

tggagtgaaa ttaaaagcca tcccctcaga tggcaacttc gccatgcgtg cgtctgccct     2040

gcaggaagcc ctggagagag acaaagcggc tggcctgatt cctttcttta tggttgccac     2100

cctggggacc acaacatgct gctcctttga caatctctta gaagtcggtc ctatctgcaa     2160

caaggaagac atatggctgc acgttgatgc agcctacgca ggcagtgcat tcatctgccc     2220

tgagttccgg caccttctga atggagtgga gtttgcagat tcattcaact ttaatcccca     2280

caaatggcta ttggtgaatt ttgactgttc tgccatgtgg gtgaaaaaga gaacagactt     2340

aacgggagcc tttagactgg accccactta cctgaagcac agccatcagg attcagggct     2400

tatcactgac taccggcatt ggcagatacc actgggcaga agatttcgct ctttgaaaat     2460

gtggtttgta tttaggatgt atggagtcaa aggactgcag gcttatatcc gcaagcatgt     2520

ccagctgtcc catgagtttg agtcactggt gcgccaggat ccccgctttg aaatctgtgt     2580

ggaagtcatt ctggggcttg tctgctttcg gctaaagggt tccaacaaag tgaatgaagc     2640

tcttctgcaa agaataaaca gtgccaaaaa aatccacttg gttccatgtc acctcaggga     2700

caagtttgtc ctgcgctttg ccatctgttc tcgcacggtg gaatctgccc atgtgcagcg     2760

ggcctgggaa cacatcaaag agctggcggc cgacgtgctg cgagcagaga gggagtagga     2820

gtgaagccag ctgcaggaat caaaaattga agagagatat atctgaaaac tggaataaga     2880

agcaaataaa tatcatcctg ccttcatgga actcagctgt ctgtggcttc ccatgtcttt     2940

ctccaaagtt atccagaggg ttgtgatttt gtctgcttag tatctcatca acaaagaaat     3000

attatttgct aattaaaaag ttaatcttca tggccatagc ttttattcat tagctgtgat     3060

ttttgttgat taaaacatta tagattttca tgttcttgca gtcatcagaa gtggtaggaa     3120

agcctcactg atatattttc cagggcaatc aatgttcacg caacttgaaa ttatatctgt     3180

ggtcttcaaa ttgtcttttg tcatgtggct aaatgcctaa taaggaatta attcgatatc     3240

aagctatcca acacactggt agggataaca gggtaatctc gaggcaagct tgggcccggt     3300

acccaattcg ccctatagtg agtcgtatta cgcgcgcagc ggccgaccat ggcccaactt     3360

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     3420

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca     3480

tgtctggatc tccggacacg tgcggaccga gcggccgctc tagagcatgg ctacgtagat     3540

aagtagcatg gcgggttaat cattaactac aaggaacccc tagtgatgga gttggccact     3600

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     3660

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gat                       3703


