                         SEQUENCE LISTING

<110>  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF 
       ARIZONA
       GARCIA, Joe G.N.
       HECKER, Louise
 
<120>  COMPOSITIONS AND METHODS FOR TREATING PULMONARY FIBROSIS

<130>  UA 17-154 PCT

<150>  62/485,863
<151>  2017-04-14

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1476
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaatcctg cggcagaagc cgagttcaac atcctcctgg ccaccgactc ctacaaggtt       60

actcactata aacaatatcc acccaacaca agcaaagttt attcctactt tgaatgccgt      120

gaaaagaaga cagaaaactc caaattaagg aaggtgaaat atgaggaaac agtattttat      180

gggttgcagt acattcttaa taagtactta aaaggtaaag tagtaaccaa agagaaaatc      240

caggaagcca aagatgtcta caaagaacat ttccaagatg atgtctttaa tgaaaaggga      300

tggaactaca ttcttgagaa gtatgatggg catcttccaa tagaaataaa agctgttcct      360

gagggctttg tcattcccag aggaaatgtt ctcttcacgg tggaaaacac agatccagag      420

tgttactggc ttacaaattg gattgagact attcttgttc agtcctggta tccaatcaca      480

gtggccacaa attctagaga gcagaagaaa atattggcca aatatttgtt agaaacttct      540

ggtaacttag atggtctgga atacaagtta catgattttg gctacagagg agtctcttcc      600

caagagactg ctggcatagg agcatctgct cacttggtta acttcaaagg aacagataca      660

gtagcaggac ttgctctaat taaaaaatat tatggaacga aagatcctgt tccaggctat      720

tctgttccag cagcagaaca cagtaccata acagcttggg ggaaagacca tgaaaaagat      780

gcttttgaac atattgtaac acagttttca tcagtgcctg tatctgtggt cagcgatagc      840

tatgacattt ataatgcgtg tgagaaaata tggggtgaag atctaagaca tttaatagta      900

tcgagaagta cacaggcacc actaataatc agacctgatt ctggaaaccc tcttgacact      960

gtgttaaagg ttttggagat tttaggtaag aagtttcctg ttactgagaa ctcaaagggt     1020

tacaagttgc tgccacctta tcttagagtt attcaagggg atggagtaga tattaatacc     1080

ttacaagaga ttgtagaagg catgaaacaa aaaatgtgga gtattgaaaa tattgccttc     1140

ggttctggtg gaggtttgct acagaagttg acaagagatc tcttgaattg ttccttcaag     1200

tgtagctatg ttgtaactaa tggccttggg attaacgtct tcaaggaccc agttgctgat     1260

cccaacaaaa ggtccaaaaa gggccgatta tctttacata ggacgccagc agggaatttt     1320

gttacactgg aggaaggaaa aggagacctt gaggaatatg gtcaggatct tctccatact     1380

gtcttcaaga atggcaaggt gacaaaaagc tattcatttg atgaaataag aaaaaatgca     1440

cagctgaata ttgaactgga agcagcacat cattag                               1476


<210>  2
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Pro Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Leu Arg Lys Val Lys Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Asp Val Tyr Lys Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Lys Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Ile Lys Ala Val Pro Glu Gly Phe Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Leu 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Gln Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Glu Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly 
    370                 375                 380                 


Gly Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Leu Glu Ala Ala His His 
                485                 490     


<210>  3
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  3
atgatgtctg cctcgcgcct ggctgggact ctgatcccag ccatggcctt cctctcctgc       60

gtgagaccag aaagctggga gccctgcgtg gaggtggttc ctaatattac ttatcaatgc      120

atggagctga atttctacaa aatccccgac aacctcccct tctcaaccaa gaacctggac      180

ctgagcttta atcccctgag gcatttaggc agctatagct tcttcagttt cccagaactg      240

caggtgctgg atttatccag gtgtgaaatc cagacaattg aagatggggc atatcagagc      300

ctaagccacc tctctacctt aatattgaca ggaaacccca tccagagttt agccctggga      360

gccttttctg gactatcaag tttacagaag ctggtggctg tggagacaaa tctagcatct      420

ctagagaact tccccattgg acatctcaaa actttgaaag aacttaatgt ggctcacaat      480

cttatccaat ctttcaaatt acctgagtat ttttctaatc tgaccaatct agagcacttg      540

gacctttcca gcaacaagat tcaaagtatt tattgcacag acttgcgggt tctacatcaa      600

atgcccctac tcaatctctc tttagacctg tccctgaacc ctatgaactt tatccaacca      660

ggtgcattta aagaaattag gcttcataag ctgactttaa gaaataattt tgatagttta      720

aatgtaatga aaacttgtat tcaaggtctg gctggtttag aagtccatcg tttggttctg      780

ggagaattta gaaatgaagg aaacttggaa aagtttgaca aatctgctct agagggcctg      840

tgcaatttga ccattgaaga attccgatta gcatacttag actactacct cgatgatatt      900

attgacttat ttaattgttt gacaaatgtt tcttcatttt ccctggtgag tgtgactatt      960

gaaagggtaa aagacttttc ttataatttc ggatggcaac atttagaatt agttaactgt     1020

aaatttggac agtttcccac attgaaactc aaatctctca aaaggcttac tttcacttcc     1080

aacaaaggtg ggaatgcttt ttcagaagtt gatctaccaa gccttgagtt tctagatctc     1140

agtagaaatg gcttgagttt caaaggttgc tgttctcaaa gtgattttgg gacaaccagc     1200

ctaaagtatt tagatctgag cttcaatggt gttattacca tgagttcaaa cttcttgggc     1260

ttagaacaac tagaacatct ggatttccag cattccaatt tgaaacaaat gagtgagttt     1320

tcagtattcc tatcactcag aaacctcatt taccttgaca tttctcatac tcacaccaga     1380

gttgctttca atggcatctt caatggcttg tccagtctcg aagtcttgaa aatggctggc     1440

aattctttcc aggaaaactt ccttccagat atcttcacag agctgagaaa cttgaccttc     1500

ctggacctct ctcagtgtca actggagcag ttgtctccaa cagcatttaa ctcactctcc     1560

agtcttcagg tactaaatat gagccacaac aacttctttt cattggatac gtttccttat     1620

aagtgtctga actccctcca ggttcttgat tacagtctca atcacataat gacttccaaa     1680

aaacaggaac tacagcattt tccaagtagt ctagctttct taaatcttac tcagaatgac     1740

tttgcttgta cttgtgaaca ccagagtttc ctgcaatgga tcaaggacca gaggcagctc     1800

ttggtggaag ttgaacgaat ggaatgtgca acaccttcag ataagcaggg catgcctgtg     1860

ctgagtttga atatcacctg tcagatgaat aagaccatca ttggtgtgtc ggtcctcagt     1920

gtgcttgtag tatctgttgt agcagttctg gtctataagt tctattttca cctgatgctt     1980

cttgctggct gcataaagta tggtagaggt gaaaacatct atgatgcctt tgttatctac     2040

tcaagccagg atgaggactg ggtaaggaat gagctagtaa agaatttaga agaaggggtg     2100

cctccatttc agctctgcct tcactacaga gactttattc ccggtgtggc cattgctgcc     2160

aacatcatcc atgaaggttt ccataaaagc cgaaaggtga ttgttgtggt gtcccagcac     2220

ttcatccaga gccgctggtg tatctttgaa tatgagattg ctcagacctg gcagtttctg     2280

agcagtcgtg ctggtatcat cttcattgtc ctgcagaagg tggagaagac cctgctcagg     2340

cagcaggtgg agctgtaccg ccttctcagc aggaacactt acctggagtg ggaggacagt     2400

gtcctggggc ggcacatctt ctggagacga ctcagaaaag ccctgctgga tggtaaatca     2460

tggaatccag aaggaacagt gggtacagga tgcaattggc aggaagcaac atctatctga     2520


<210>  4
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Glu Gly Lys Gly Asp Leu Glu Glu Tyr Gly His Asp Leu 
1               5                   10              


