                         SEQUENCE LISTING

<110>  Dorn, Gerald W II
 
<120>  SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF 
       USE THEREOF

<130>  017291-WO

<150>  US 62/488,787
<151>  2017-04-23

<150>  US 62/584,515
<151>  2017-11-10

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1

His His His His His His Gly Gly Gly Gly Ala Ala Met Asn Lys Lys 
1               5                   10                  15      


Ile Glu Val Leu Asp Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn 
            20                  25                  30          


Lys Ala Gly Gly 
        35      


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Gly Gly Gly Gly Ala Val Arg Gly Ile Met Asp Asp Leu His Met Ala 
1               5                   10                  15      


Ala Arg Gly Gly 
            20  


<210>  3
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

His His His His His His Gly Gly Gly Gly Leu His Ala Phe Thr Gly 
1               5                   10                  15      


Ser Leu Glu Gln Gln Val Gln His Ser Cys Asn Ser Gly Gly Gly 
            20                  25                  30      


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Gly Gly Gly Gly Lys Gln Leu Glu Leu Leu Ala Gln Asp Tyr Lys Leu 
1               5                   10                  15      


Arg Ile Lys Gln Gly Gly 
            20          


<210>  5
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Pro Val Ser Pro Leu Lys His Phe Val Leu Ala Lys Lys 
1               5                   10                  15      


Ala Ile Thr Ala Ile Phe Asp Gln Leu Leu Glu Phe Val Thr Glu Gly 
            20                  25                  30          


Ser His Phe Val Glu Ala Thr Tyr Lys Asn Pro Glu Leu Asp Arg Ile 
        35                  40                  45              


Ala Thr Glu Asp Asp Leu Val Glu Met Gln Gly Tyr Lys Asp Lys Leu 
    50                  55                  60                  


Ser Ile Ile Gly Glu Val Leu Ser Arg Arg His Met Lys Val Ala Phe 
65                  70                  75                  80  


Phe Gly Arg Thr Ser Ser Gly Lys Ser Ser Val Ile Asn Ala Met Leu 
                85                  90                  95      


Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His Ile Thr Asn Cys Phe 
            100                 105                 110         


Leu Ser Val Glu Gly Thr Asp Gly Asp Lys Ala Tyr Leu Met Thr Glu 
        115                 120                 125             


Gly Ser Asp Glu Lys Lys Ser Val Lys Thr Val Asn Gln Leu Ala His 
    130                 135                 140                 


Ala Leu His Met Asp Lys Asp Leu Lys Ala Gly Cys Leu Val Arg Val 
145                 150                 155                 160 


Phe Trp Pro Lys Ala Lys Cys Ala Leu Leu Arg Asp Asp Leu Val Leu 
                165                 170                 175     


Val Asp Ser Pro Gly Thr Asp Val Thr Thr Glu Leu Asp Ser Trp Ile 
            180                 185                 190         


Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val Leu Val Ala Asn Ser 
        195                 200                 205             


Glu Ser Thr Leu Met Asn Thr Glu Lys His Phe Phe His Lys Val Asn 
    210                 215                 220                 


Glu Arg Leu Ser Lys Pro Asn Ile Phe Ile Leu Asn Asn Arg Trp Asp 
225                 230                 235                 240 


Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Asp Val Arg Arg Gln His 
                245                 250                 255     


Met Glu Arg Cys Leu His Phe Leu Val Glu Glu Leu Lys Val Val Asn 
            260                 265                 270         


Ala Leu Glu Ala Gln Asn Arg Ile Phe Phe Val Ser Ala Lys Glu Val 
        275                 280                 285             


Leu Ser Ala Arg Lys Gln Lys Ala Gln Gly Met Pro Glu Ser Gly Val 
    290                 295                 300                 


Ala Leu Ala Glu Gly Phe His Ala Arg Leu Gln Glu Phe Gln Asn Phe 
305                 310                 315                 320 


Glu Gln Ile Phe Glu Glu Cys Ile Ser Gln Ser Ala Val Lys Thr Lys 
                325                 330                 335     


Phe Glu Gln His Thr Ile Arg Ala Lys Gln Ile Leu Ala Thr Val Lys 
            340                 345                 350         


Asn Ile Met Asp Ser Val Asn Leu Ala Ala Glu Asp Lys Arg His Tyr 
        355                 360                 365             


Ser Val Glu Glu Arg Glu Asp Gln Ile Asp Arg Leu Asp Phe Ile Arg 
    370                 375                 380                 


Asn Gln Met Asn Leu Leu Thr Leu Asp Val Lys Lys Lys Ile Lys Glu 
385                 390                 395                 400 


Val Thr Glu Glu Val Ala Asn Lys Val Ser Cys Ala Met Thr Asp Glu 
                405                 410                 415     


Ile Cys Arg Leu Ser Val Leu Val Asp Glu Phe Cys Ser Glu Phe His 
            420                 425                 430         


Pro Asn Pro Asp Val Leu Lys Ile Tyr Lys Ser Glu Leu Asn Lys His 
        435                 440                 445             


Ile Glu Asp Gly Met Gly Arg Asn Leu Ala Asp Arg Cys Thr Asp Glu 
    450                 455                 460                 


Val Asn Ala Leu Val Leu Gln Thr Gln Gln Glu Ile Ile Glu Asn Leu 
465                 470                 475                 480 


Lys Pro Leu Leu Pro Ala Gly Ile Gln Asp Lys Leu His Thr Leu Ile 
                485                 490                 495     


Pro Cys Lys Lys Phe Asp Leu Ser Tyr Asn Leu Asn Tyr His Lys Leu 
            500                 505                 510         


Cys Ser Asp Phe Gln Glu Asp Ile Val Phe Arg Phe Ser Leu Gly Trp 
        515                 520                 525             


Ser Ser Leu Val His Arg Phe Leu Gly Pro Arg Asn Ala Gln Arg Val 
    530                 535                 540                 


Leu Leu Gly Leu Ser Glu Pro Ile Phe Gln Leu Pro Arg Ser Leu Ala 
545                 550                 555                 560 


Ser Thr Pro Thr Ala Pro Thr Thr Pro Ala Thr Pro Asp Asn Ala Ser 
                565                 570                 575     


Gln Glu Glu Leu Met Ile Thr Leu Val Thr Gly Leu Ala Ser Val Thr 
            580                 585                 590         


Ser Arg Thr Ser Met Gly Ile Ile Ile Val Gly Gly Val Ile Trp Lys 
        595                 600                 605             


Thr Ile Gly Trp Lys Leu Leu Ser Val Ser Leu Thr Met Tyr Gly Ala 
    610                 615                 620                 


Leu Tyr Leu Tyr Glu Arg Leu Ser Trp Thr Thr His Ala Lys Glu Arg 
625                 630                 635                 640 


Ala Phe Lys Gln Gln Phe Val Asn Tyr Ala Thr Glu Lys Leu Arg Met 
                645                 650                 655     


Ile Val Ser Ser Thr Ser Ala Asn Cys Ser His Gln Val Lys Gln Gln 
            660                 665                 670         


Ile Ala Thr Thr Phe Ala Arg Leu Cys Gln Gln Val Asp Ile Thr Gln 
        675                 680                 685             


Lys Gln Leu Glu Glu Glu Ile Ala Arg Leu Pro Lys Glu Ile Asp Gln 
    690                 695                 700                 


Leu Glu Lys Ile Gln Asn Asn Ser Lys Leu Leu Arg Asn Lys Ala Val 
705                 710                 715                 720 


Gln Leu Glu Asn Glu Leu Glu Asn Phe Thr Lys Gln Phe Leu Pro Ser 
                725                 730                 735     


Ser Asn Glu Glu Ser 
            740     


<210>  6
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Leu Leu Phe Ser Arg Cys Asn Ser Ile Val Thr Val Lys Lys 
1               5                   10                  15      


Asn Lys Arg His Met Ala Glu Val Asn Ala Ser Pro Leu Lys His Phe 
            20                  25                  30          


Val Thr Ala Lys Lys Lys Ile Asn Gly Ile Phe Glu Gln Leu Gly Ala 
        35                  40                  45              


Tyr Ile Gln Glu Ser Ala Thr Phe Leu Glu Asp Thr Tyr Arg Asn Ala 
    50                  55                  60                  


Glu Leu Asp Pro Val Thr Thr Glu Glu Gln Val Leu Asp Val Lys Gly 
65                  70                  75                  80  


Tyr Leu Ser Lys Val Arg Gly Ile Ser Glu Val Leu Ala Arg Arg His 
                85                  90                  95      


Met Lys Val Ala Phe Phe Gly Arg Thr Ser Asn Gly Lys Ser Thr Val 
            100                 105                 110         


Ile Asn Ala Met Leu Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His 
        115                 120                 125             


Thr Thr Asn Cys Phe Leu Arg Val Glu Gly Thr Asp Gly His Glu Ala 
    130                 135                 140                 


Phe Leu Leu Thr Glu Gly Ser Glu Glu Lys Arg Ser Ala Lys Thr Val 
145                 150                 155                 160 


Asn Gln Leu Ala His Ala Leu His Gln Asp Lys Gln Leu His Ala Gly 
                165                 170                 175     


Ser Leu Val Ser Val Met Trp Pro Asn Ser Lys Cys Pro Leu Leu Lys 
            180                 185                 190         


Asp Asp Leu Val Leu Met Asp Ser Pro Gly Ile Asp Val Thr Thr Glu 
        195                 200                 205             


Leu Asp Ser Trp Ile Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val 
    210                 215                 220                 


Leu Val Ala Asn Ser Glu Ser Thr Leu Met Gln Thr Glu Lys His Phe 
225                 230                 235                 240 


Phe His Lys Val Ser Glu Arg Leu Ser Arg Pro Asn Ile Phe Ile Leu 
                245                 250                 255     


Asn Asn Arg Trp Asp Ala Ser Ala Ser Glu Pro Glu Tyr Met Glu Glu 
            260                 265                 270         


Val Arg Arg Gln His Met Glu Arg Cys Thr Ser Phe Leu Val Asp Glu 
        275                 280                 285             


Leu Gly Val Val Asp Arg Ser Gln Ala Gly Asp Arg Ile Phe Phe Val 
    290                 295                 300                 


Ser Ala Lys Glu Val Leu Asn Ala Arg Ile Gln Lys Ala Gln Gly Met 
305                 310                 315                 320 


Pro Glu Gly Gly Gly Ala Leu Ala Glu Gly Phe Gln Val Arg Met Phe 
                325                 330                 335     


Glu Phe Gln Asn Phe Glu Arg Arg Phe Glu Glu Cys Ile Ser Gln Ser 
            340                 345                 350         


Ala Val Lys Thr Lys Phe Glu Gln His Thr Val Arg Ala Lys Gln Ile 
        355                 360                 365             


Ala Glu Ala Val Arg Leu Ile Met Asp Ser Leu His Met Ala Ala Arg 
    370                 375                 380                 


Glu Gln Gln Val Tyr Cys Glu Glu Met Arg Glu Glu Arg Gln Asp Arg 
385                 390                 395                 400 


Leu Lys Phe Ile Asp Lys Gln Leu Glu Leu Leu Ala Gln Asp Tyr Lys 
                405                 410                 415     


Leu Arg Ile Lys Gln Ile Thr Glu Glu Val Glu Arg Gln Val Ser Thr 
            420                 425                 430         


Ala Met Ala Glu Glu Ile Arg Arg Leu Ser Val Leu Val Asp Asp Tyr 
        435                 440                 445             


Gln Met Asp Phe His Pro Ser Pro Val Val Leu Lys Val Tyr Lys Asn 
    450                 455                 460                 


Glu Leu His Arg His Ile Glu Glu Gly Leu Gly Arg Asn Met Ser Asp 
465                 470                 475                 480 


Arg Cys Ser Thr Ala Ile Thr Asn Ser Leu Gln Thr Met Gln Gln Asp 
                485                 490                 495     


Met Ile Asp Gly Leu Lys Pro Leu Leu Pro Val Ser Val Arg Ser Gln 
            500                 505                 510         


Ile Asp Met Leu Val Pro Arg Gln Cys Phe Ser Leu Asn Tyr Asp Leu 
        515                 520                 525             


Asn Cys Asp Lys Leu Cys Ala Asp Phe Gln Glu Asp Ile Glu Phe His 
    530                 535                 540                 


Phe Ser Leu Gly Trp Thr Met Leu Val Asn Arg Phe Leu Gly Pro Lys 
545                 550                 555                 560 


Asn Ser Arg Arg Ala Leu Met Gly Tyr Asn Asp Gln Val Gln Arg Pro 
                565                 570                 575     


Ile Pro Leu Thr Pro Ala Asn Pro Ser Met Pro Pro Leu Pro Gln Gly 
            580                 585                 590         


Ser Leu Thr Gln Glu Glu Phe Met Val Ser Met Val Thr Gly Leu Ala 
        595                 600                 605             


Ser Leu Thr Ser Arg Thr Ser Met Gly Ile Leu Val Val Gly Gly Val 
    610                 615                 620                 


Val Trp Lys Ala Val Gly Trp Arg Leu Ile Ala Leu Ser Phe Gly Leu 
625                 630                 635                 640 


Tyr Gly Leu Leu Tyr Val Tyr Glu Arg Leu Thr Trp Thr Thr Lys Ala 
                645                 650                 655     


Lys Glu Arg Ala Phe Lys Arg Gln Phe Val Glu His Ala Ser Glu Lys 
            660                 665                 670         


Leu Gln Leu Val Ile Ser Tyr Thr Gly Ser Asn Cys Ser His Gln Val 
        675                 680                 685             


Gln Gln Glu Leu Ser Gly Thr Phe Ala His Leu Cys Gln Gln Val Asp 
    690                 695                 700                 


Val Thr Arg Glu Asn Leu Glu Gln Glu Ile Ala Ala Met Asn Lys Lys 
705                 710                 715                 720 


Ile Glu Val Leu Asp Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn 
                725                 730                 735     


Lys Ala Gly Trp Leu Asp Ser Glu Leu Asn Met Phe Thr His Gln Tyr 
            740                 745                 750         


Leu Gln Pro Ser Arg 
        755         


<210>  7
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
cgactcatca tggacgacct gcacatggcg gc                                     32


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
gccgccatgt gcaggtcgtc catgatgagt cg                                     32


<210>  9
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
gactcatcat ggacgccctg cacatggcg                                         29


<210>  10
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
cgccatgtgc agggcgtcca tgatgagtc                                         29


<210>  11
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Gly Ile Ala Asp Ser Leu His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Gly Ile Met Ala Ser Leu His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Gly Ile Met Asp Ala Leu His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Gly Ile Met Asp Ser Ala His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  15
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Gly Ile Met Asp Ser Leu Ala Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Gly Ile Met Asp Ser Leu His Ala Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  17
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Gly Ile Met Asp Asp Leu His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa represents phosphorylation of serine

<400>  18

Gly Ile Met Asp Xaa Leu His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  19
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Gly Ile Met Asp Gly Leu His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  20
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Gly Ile Met Asp Cys Leu His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  21
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  21

Gly Ile Met Asp Asn Leu His Met Ala Ala Arg Gly Gly Tyr Gly Arg 
1               5                   10                  15      


Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Ala Val Arg Gly Ile Met Asp Ser Leu His Met Ala Ala Arg 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa represents phosphorylation of serine

<400>  23

Ala Val Arg Gly Ile Met Asp Xaa Leu His Met Ala Ala Arg 
1               5                   10                  


<210>  24
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  24

His His His His His His Gly Gly Gly Gly Ala Ala Met Asn Lys Lys 
1               5                   10                  15      


Ile Glu Val Leu Asp Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn 
            20                  25                  30          


Lys Ala Gly Gly 
        35      


<210>  25
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  25

His His His His His His Gly Gly Gly Gly Ala Ala Met Asn Lys Lys 
1               5                   10                  15      


Ile Glu Val Ala Ala Ser Ala Gln Ser Lys Ala Lys Leu Leu Arg Asn 
            20                  25                  30          


Lys Ala Gly Gly 
        35      


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Gly Gly Gly Gly Ala Val Arg Gly Ile Met Asp Ser Leu His Met Ala 
1               5                   10                  15      


Ala Arg Gly Gly 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Gly Gly Gly Gly Ala Val Arg Gly Ile Met Asp Asp Leu His Met Ala 
1               5                   10                  15      


Ala Arg Gly Gly 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Gly Gly Gly Gly Ala Val Arg Gly Ile Met Asp Ala Leu His Met Ala 
1               5                   10                  15      


Ala Arg Gly Gly 
            20  


