                         SEQUENCE LISTING

<110>  Julius-Maximilians-Universitt Wrzburg
       Bruttel, Dr. rer. nat. , Valentin
 
<120>  Combinations of MHC class Ib molecules and Peptides for Targeted 
       Therapeutic Immunomodulation

<130>  204713

<150>  EP 17 172 444.6
<151>  2017-05-23

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader Peptide

<400>  1

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala 
            20  


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide antigen: STEAP1

<400>  2

Met Leu Ala Val Phe Leu Pro Ile Val 
1               5                   


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide antigen: Ova

<400>  3

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker1 (disulfide trap stabilized)

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker1 (disulfide trap stabilized)

<400>  5

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  6
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human beta 3 Microglobulin

<400>  6

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker2

<400>  7

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  8
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [Alpha] 1 & 2 domain

<400>  8

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys 
    130                 135                 140                 


Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Met Leu Gln Arg Ala 
            180         


<210>  9
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine H2Kb [alpha]1 & 2 domain (Y84C)

<400>  9

Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Leu Gly Glu Pro Arg Tyr Met Glu Val Gly Tyr Val Asp Asp Thr Glu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Tyr Glu Pro Arg 
        35                  40                  45              


Ala Arg Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Arg Glu Thr 
    50                  55                  60                  


Gln Lys Ala Lys Gly Asn Glu Gln Ser Phe Arg Val Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Leu Gly Cys Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Ile Gln 
                85                  90                  95      


Val Ile Ser Gly Cys Glu Val Gly Ser Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Tyr Ala Tyr Asp Gly Cys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Lys Thr Trp Thr Ala Ala Asp Met Ala Ala Leu Ile Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Gln Ala Gly Glu Ala Glu Arg Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly Asn 
                165                 170                 175     


Ala Thr Leu Leu Arg Thr 
            180         


<210>  10
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA-A2 [alpha]1 & 2 domain

<400>  10

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr 
            180         


<210>  11
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of HLA-G [alpha]3

<400>  11

Asp Pro Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu 
1               5                   10                  15      


Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile 
            20                  25                  30          


Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu 
        35                  40                  45              


Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala 
    50                  55                  60                  


Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln 
65                  70                  75                  80  


His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Ser Lys Glu Gly 
                85                  90                  95      


Asp Gly Gly Ile Met Ser Val Arg Glu Ser Arg Ser Leu Ser Glu Asp 
            100                 105                 110         


Leu 
    


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor Xa restriction site

<400>  12

Ile Glu Gly Arg Thr Gly Thr Lys Leu Gly Pro 
1               5                   10      


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  13

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  14

His His His His His His 
1               5       


<210>  15
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dtH2Gova

<400>  15

Ser Ile Ile Asn Phe Glu Lys Leu Gly Cys Gly Ala Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val 
            20                  25                  30          


Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys 
        35                  40                  45              


Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys 
    50                  55                  60                  


Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser 
65                  70                  75                  80  


Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr 
                85                  90                  95      


Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln 
            100                 105                 110         


Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro 
    130                 135                 140                 


His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly Leu Gly 
145                 150                 155                 160 


Glu Pro Arg Tyr Met Glu Val Gly Tyr Val Asp Asp Thr Glu Phe Val 
                165                 170                 175     


Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg 
            180                 185                 190         


Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Arg Glu Thr Gln Lys 
        195                 200                 205             


Ala Lys Gly Asn Glu Gln Ser Phe Arg Val Asp Leu Arg Thr Leu Leu 
    210                 215                 220                 


Gly Cys Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Ile Gln Val Ile 
225                 230                 235                 240 


Ser Gly Cys Glu Val Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr Gln 
                245                 250                 255     


Gln Tyr Ala Tyr Asp Gly Cys Asp Tyr Ile Ala Leu Asn Glu Asp Leu 
            260                 265                 270         


Lys Thr Trp Thr Ala Ala Asp Met Ala Ala Leu Ile Thr Lys His Lys 
        275                 280                 285             


Trp Glu Gln Ala Gly Glu Ala Glu Arg Leu Arg Ala Tyr Leu Glu Gly 
    290                 295                 300                 


Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly Asn Ala Thr 
305                 310                 315                 320 


Leu Leu Arg Thr Asp Pro Pro Lys Thr His Val Thr His His Pro Val 
                325                 330                 335     


Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro 
            340                 345                 350         


Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln 
        355                 360                 365             


Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
    370                 375                 380                 


Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr 
385                 390                 395                 400 


Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp 
                405                 410                 415     


Ser Lys Glu Gly Asp Gly Gly Ile Met Ser Val Arg Glu Ser Arg Ser 
            420                 425                 430         


Leu Ser Glu Asp Leu Ile Glu Gly Arg Thr Gly Thr Lys Leu Gly Pro 
        435                 440                 445             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His 
    450                 455                 460                 


His His His His His 
465                 


<210>  16
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dtGsteap

<400>  16

Met Leu Ala Val Phe Leu Pro Ile Val Gly Cys Gly Ala Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr Arg 
        195                 200                 205             


Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr Leu 
    210                 215                 220                 


Arg Gly Cys Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln Trp 
225                 230                 235                 240 


Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr 
                245                 250                 255     


Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys Arg 
        275                 280                 285             


Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
                325                 330                 335     


Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
        355                 360                 365             


Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg 
                405                 410                 415     


Trp Ser Lys Glu Gly Asp Gly Gly Ile Met Ser Val Arg Glu Ser Arg 
            420                 425                 430         


Ser Leu Ser Glu Asp Leu Ile Glu Gly Arg Thr Gly Thr Lys Leu Gly 
        435                 440                 445             


Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp 
    450                 455                 460                 


His His His His His His 
465                 470 


<210>  17
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ILT2

<400>  17

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Leu Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
545                 550                 555                 560 


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
                565                 570                 575     


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
            580                 585                 590         


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
        595                 600                 605             


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
    610                 615                 620                 


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
625                 630                 635                 640 


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650 


<210>  18
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ILT4

<400>  18

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Glu Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
545                 550                 555                 560 


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu 
                565                 570                 575     


Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr 
            580                 585                 590         


Ala Thr Leu Ala Ile His 
        595             


