                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> ANTIBODY-CYTOKINE ENGRAFTED PROTEINS AND METHODS OF USE IN THE 
      TREATMENT OF CANCER

<130> PAT057462-WO-PCT

<140>
<141>

<150> 62/510,533
<151> 2017-05-24

<160> 78    

<170> PatentIn version 3.5

<210> 1
<211> 822
<212> DNA
<213> Homo sapiens

<400> 1
agttccctat cactctcttt aatcactact cacagtaacc tcaactcctg ccacaatgta       60

caggatgcaa ctcctgtctt gcattgcact aagtcttgca cttgtcacaa acagtgcacc      120

tacttcaagt tctacaaaga aaacacagct acaactggag catttactgc tggatttaca      180

gatgattttg aatggaatta ataattacaa gaatcccaaa ctcaccagga tgctcacatt      240

taagttttac atgcccaaga aggccacaga actgaaacat cttcagtgtc tagaagaaga      300

actcaaacct ctggaggaag tgctaaattt agctcaaagc aaaaactttc acttaagacc      360

cagggactta atcagcaata tcaacgtaat agttctggaa ctaaagggat ctgaaacaac      420

attcatgtgt gaatatgctg atgagacagc aaccattgta gaatttctga acagatggat      480

taccttttgt caaagcatca tctcaacact gacttgataa ttaagtgctt cccacttaaa      540

acatatcagg ccttctattt atttaaatat ttaaatttta tatttattgt tgaatgtatg      600

gtttgctacc tattgtaact attattctta atcttaaaac tataaatatg gatcttttat      660

gattcttttt gtaagcccta ggggctctaa aatggtttca cttatttatc ccaaaatatt      720

tattattatg ttgaatgtta aatatagtat ctatgtagat tggttagtaa aactatttaa      780

taaatttgat aaatataaaa aaaaaaaaaa aaaaaaaaaa aa                         822


<210> 2
<211> 153
<212> PRT
<213> Homo sapiens

<400> 2
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 3
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 3
caagtcacac tgcgtgaaag cggccctgcc ctggtcaagc ccacccagac cctgaccctg       60

acctgcacct tctccggctt cagcctggcc cctacctcct ccagcaccaa gaaaacccag      120

ctgcagctcg aacatctgct gctggacctg cagatgatcc tgaacggcat caacaactac      180

aagaacccca agctgacccg gatgctgacc gccaagttct acatgcccaa gaaggccacc      240

gagctgaaac atctgcagtg cctggaagag gaactgaagc ccctggaaga agtgctgaac      300

ctggcccagt ccaagaactt ccacctgagg cctcgggacc tgatctccaa catcaacgtg      360

atcgtgctgg aactgaaggg ctccgagaca accttcatgt gcgagtacgc cgacgagaca      420

gccaccatcg tggaatttct gaaccggtgg atcaccttct gccagtccat catctccacc      480

ctgacctcca cctccggcat gtccgtgggc tggatccggc agcctcctgg caaggccctg      540

gagtggctgg ccgacatttg gtgggacgac aagaaggact acaaccccag cctgaagtcc      600

cggctgacca tctccaagga cacctccaag aaccaagtgg tgctgaaagt gaccaacatg      660

gaccccgccg acaccgccac ctactactgc gcccggtcca tgatcaccaa ctggtacttc      720

gacgtgtggg gcgctggcac caccgtgacc gtgtcctct                             759


<210> 4
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210> 5
<211> 399
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
gcccctacct cctccagcac caagaaaacc cagctgcagc tcgaacatct gctgctggac       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accgccaagt tctacatgcc caagaaggcc accgagctga aacatctgca gtgcctggaa      180

gaggaactga agcccctgga agaagtgctg aacctggccc agtccaagaa cttccacctg      240

aggcctcggg acctgatctc caacatcaac gtgatcgtgc tggaactgaa gggctccgag      300

acaaccttca tgtgcgagta cgccgacgag acagccacca tcgtggaatt tctgaaccgg      360

tggatcacct tctgccagtc catcatctcc accctgacc                             399


<210> 6
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210> 7
<211> 145
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser Val 
    130                 135                 140                 


Gly 
145 


<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210> 10
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser Val Gly 
    130                 135                 140     


<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210> 13
<211> 142
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met 
    130                 135                 140         


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Trp Trp Asp Asp Lys 
1               5   


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210> 16
<211> 143
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser 
    130                 135                 140             


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Ile Trp Trp Asp Asp Lys Lys 
1               5           


<210> 18
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10          


<210> 19
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ala Pro Thr 
            20                  25                  30          


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
        35                  40                  45              


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
    50                  55                  60                  


Leu Thr Ala Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
65                  70                  75                  80  


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
                85                  90                  95      


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
            100                 105                 110         


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
        115                 120                 125             


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
    130                 135                 140                 


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
145                 150                 155                 160 


Leu Thr Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys 
            180                 185                 190         


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
        195                 200                 205             


Ser Lys Asn Gln Val Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp 
    210                 215                 220                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                245                 250             


<210> 20
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
caagtcacac tgcgtgaaag cggccctgcc ctggtcaagc ccacccagac cctgaccctg       60

acctgcacct tctccggctt cagcctggcc cctacctcct ccagcaccaa gaaaacccag      120

ctgcagctcg aacatctgct gctggacctg cagatgatcc tgaacggcat caacaactac      180

aagaacccca agctgaccgc catgctgacc ttcaagttct acatgcccaa gaaggccacc      240

gagctgaaac atctgcagtg cctggaagag gaactgaagc ccctggaaga agtgctgaac      300

ctggcccagt ccaagaactt ccacctgagg cctcgggacc tgatctccaa catcaacgtg      360

atcgtgctgg aactgaaggg ctccgagaca accttcatgt gcgagtacgc cgacgagaca      420

gccaccatcg tggaatttct gaaccggtgg atcaccttct gccagtccat catctccacc      480

ctgacctcca cctccggcat gtccgtgggc tggatccggc agcctcctgg caaggccctg      540

gagtggctgg ccgacatttg gtgggacgac aagaaggact acaaccccag cctgaagtcc      600

cggctgacca tctccaagga cacctccaag aaccaagtgg tgctgaaagt gaccaacatg      660

gaccccgccg acaccgccac ctactactgc gcccggtcca tgatcaccaa ctggtacttc      720

gacgtgtggg gcgctggcac caccgtgacc gtgtcctct                             759


<210> 21
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ala Pro Thr 
            20                  25                  30          


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
        35                  40                  45              


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
    50                  55                  60                  


Leu Thr Ala Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
65                  70                  75                  80  


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
                85                  90                  95      


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
            100                 105                 110         


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
        115                 120                 125             


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
    130                 135                 140                 


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
145                 150                 155                 160 


Leu Thr Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys 
            180                 185                 190         


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
        195                 200                 205             


Ser Lys Asn Gln Val Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp 
    210                 215                 220                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    450                 455                 460                 


Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    530                 535                 540                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Pro Gly Lys 
            580             


<210> 22
<211> 1749
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
caagtcacac tgcgtgaaag cggccctgcc ctggtcaagc ccacccagac cctgaccctg       60

acctgcacct tctccggctt cagcctggcc cctacctcct ccagcaccaa gaaaacccag      120

ctgcagctcg aacatctgct gctggacctg cagatgatcc tgaacggcat caacaactac      180

aagaacccca agctgaccgc catgctgacc ttcaagttct acatgcccaa gaaggccacc      240

gagctgaaac atctgcagtg cctggaagag gaactgaagc ccctggaaga agtgctgaac      300

ctggcccagt ccaagaactt ccacctgagg cctcgggacc tgatctccaa catcaacgtg      360

atcgtgctgg aactgaaggg ctccgagaca accttcatgt gcgagtacgc cgacgagaca      420

gccaccatcg tggaatttct gaaccggtgg atcaccttct gccagtccat catctccacc      480

ctgacctcca cctccggcat gtccgtgggc tggatccggc agcctcctgg caaggccctg      540

gagtggctgg ccgacatttg gtgggacgac aagaaggact acaaccccag cctgaagtcc      600

cggctgacca tctccaagga cacctccaag aaccaagtgg tgctgaaagt gaccaacatg      660

gaccccgccg acaccgccac ctactactgc gcccggtcca tgatcaccaa ctggtacttc      720

gacgtgtggg gcgctggcac caccgtgacc gtgtcctctg ctagcaccaa gggcccctcc      780

gtgttccctc tggccccttc cagcaagtct acctccggcg gcacagctgc tctgggctgc      840

ctggtcaagg actacttccc tgagcctgtg acagtgtcct ggaactctgg cgccctgacc      900

tctggcgtgc acaccttccc tgccgtgctg cagtcctccg gcctgtactc cctgtcctcc      960

gtggtcacag tgccttcaag cagcctgggc acccagacct atatctgcaa cgtgaaccac     1020

aagccttcca acaccaaggt ggacaagcgg gtggagccta agtcctgcga caagacccac     1080

acctgtcctc cctgccctgc tcctgaactg ctgggcggcc cttctgtgtt cctgttccct     1140

ccaaagccca aggacaccct gatgatctcc cggacccctg aagtgacctg cgtggtggtg     1200

gccgtgtccc acgaggatcc tgaagtgaag ttcaattggt acgtggacgg cgtggaggtg     1260

cacaacgcca agaccaagcc tcgggaggaa cagtacaact ccacctaccg ggtggtgtcc     1320

gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg caaagtctcc     1380

aacaaggccc tggccgcccc tatcgaaaag acaatctcca aggccaaggg ccagcctagg     1440

gaaccccagg tgtacaccct gccacccagc cgggaggaaa tgaccaagaa ccaggtgtcc     1500

ctgacctgtc tggtcaaggg cttctaccct tccgatatcg ccgtggagtg ggagtctaac     1560

ggccagcctg agaacaacta caagaccacc cctcctgtgc tggactccga cggctccttc     1620

ttcctgtact ccaaactgac cgtggacaag tcccggtggc agcagggcaa cgtgttctcc     1680

tgctccgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gtccctgtct     1740

cccggcaag                                                             1749


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Lys Ala Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Lys Ala Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  


<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210> 29
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Gln Leu Ser Val Gly Tyr 
1               5       


<210> 30
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Asp Thr Ser 
1           


<210> 31
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Gly Ser Gly Tyr Pro Phe 
1               5       


<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Leu Ser Val Gly Tyr 
1               5   


<210> 33
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Asp Thr Ser 
1           


<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210> 35
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210> 36
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 36
gacatccaga tgacccagag cccctccacc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacttgca aggcccagct gtccgtgggc tacatgcact ggtatcagca gaagcccggc      120

aaggccccta agctgctgat ctacgacacc tccaagctgg cctccggcgt gccctccaga      180

ttctccggct ctggctccgg caccgagttc accctgacca tctccagcct gcagcccgac      240

gacttcgcca cctactactg ttttcaaggc tccggctacc ccttcacctt cggcggaggc      300

accaagctgg aaatcaag                                                    318


<210> 37
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 38
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 38
gacatccaga tgacccagag cccctccacc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacttgca aggcccagct gtccgtgggc tacatgcact ggtatcagca gaagcccggc      120

aaggccccta agctgctgat ctacgacacc tccaagctgg cctccggcgt gccctccaga      180

ttctccggct ctggctccgg caccgagttc accctgacca tctccagcct gcagcccgac      240

gacttcgcca cctactactg ttttcaaggc tccggctacc ccttcacctt cggcggaggc      300

accaagctgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcataaggtg tacgcctgcg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210> 39
<211> 145
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser Val 
    130                 135                 140                 


Gly 
145 


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210> 42
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser Val Gly 
    130                 135                 140     


<210> 43
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 44
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210> 45
<211> 142
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met 
    130                 135                 140         


<210> 46
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Trp Trp Asp Asp Lys 
1               5   


<210> 47
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210> 48
<211> 143
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser 
    130                 135                 140             


<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Ile Trp Trp Asp Asp Lys Lys 
1               5           


<210> 50
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10          


<210> 51
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ala Pro Thr 
            20                  25                  30          


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
        35                  40                  45              


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
    50                  55                  60                  


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
65                  70                  75                  80  


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
                85                  90                  95      


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
            100                 105                 110         


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
        115                 120                 125             


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
    130                 135                 140                 


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
145                 150                 155                 160 


Leu Thr Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys 
            180                 185                 190         


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
        195                 200                 205             


Ser Lys Asn Gln Val Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp 
    210                 215                 220                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                245                 250             


<210> 52
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 52
caagtcacac tgcgtgaaag cggccctgcc ctggtcaagc ccacccagac cctgaccctg       60

acctgcacct tctccggctt cagcctggcc cctacctcct ccagcaccaa gaaaacccag      120

ctgcagctcg aacatctgct gctggacctg cagatgatcc tgaacggcat caacaactac      180

aagaacccca agctgacccg gatgctgacc gccaagttct acatgcccaa gaaggccacc      240

gagctgaaac atctgcagtg cctggaagag gaactgaagc ccctggaaga agtgctgaac      300

ctggcccagt ccaagaactt ccacctgagg cctcgggacc tgatctccaa catcaacgtg      360

atcgtgctgg aactgaaggg ctccgagaca accttcatgt gcgagtacgc cgacgagaca      420

gccaccatcg tggaatttct gaaccggtgg atcaccttct gccagtccat catctccacc      480

ctgacctcca cctccggcat gtccgtgggc tggatccggc agcctcctgg caaggccctg      540

gagtggctgg ccgacatttg gtgggacgac aagaaggact acaaccccag cctgaagtcc      600

cggctgacca tctccaagga cacctccaag aaccaagtgg tgctgaaagt gaccaacatg      660

gaccccgccg acaccgccac ctactactgc gcccggtcca tgatcaccaa ctggtacttc      720

gacgtgtggg gcgctggcac caccgtgacc gtgtcctct                             759


<210> 53
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ala Pro Thr 
            20                  25                  30          


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
        35                  40                  45              


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
    50                  55                  60                  


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
65                  70                  75                  80  


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
                85                  90                  95      


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
            100                 105                 110         


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
        115                 120                 125             


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
    130                 135                 140                 


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
145                 150                 155                 160 


Leu Thr Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys 
            180                 185                 190         


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
        195                 200                 205             


Ser Lys Asn Gln Val Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp 
    210                 215                 220                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    450                 455                 460                 


Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    530                 535                 540                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Pro Gly Lys 
            580             


<210> 54
<211> 1749
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 54
caagtcacac tgcgtgaaag cggccctgcc ctggtcaagc ccacccagac cctgaccctg       60

acctgcacct tctccggctt cagcctggcc cctacctcct ccagcaccaa gaaaacccag      120

ctgcagctcg aacatctgct gctggacctg cagatgatcc tgaacggcat caacaactac      180

aagaacccca agctgacccg gatgctgacc gccaagttct acatgcccaa gaaggccacc      240

gagctgaaac atctgcagtg cctggaagag gaactgaagc ccctggaaga agtgctgaac      300

ctggcccagt ccaagaactt ccacctgagg cctcgggacc tgatctccaa catcaacgtg      360

atcgtgctgg aactgaaggg ctccgagaca accttcatgt gcgagtacgc cgacgagaca      420

gccaccatcg tggaatttct gaaccggtgg atcaccttct gccagtccat catctccacc      480

ctgacctcca cctccggcat gtccgtgggc tggatccggc agcctcctgg caaggccctg      540

gagtggctgg ccgacatttg gtgggacgac aagaaggact acaaccccag cctgaagtcc      600

cggctgacca tctccaagga cacctccaag aaccaagtgg tgctgaaagt gaccaacatg      660

gaccccgccg acaccgccac ctactactgc gcccggtcca tgatcaccaa ctggtacttc      720

gacgtgtggg gcgctggcac caccgtgacc gtgtcctctg ctagcaccaa gggcccctcc      780

gtgttccctc tggccccttc cagcaagtct acctccggcg gcacagctgc tctgggctgc      840

ctggtcaagg actacttccc tgagcctgtg acagtgtcct ggaactctgg cgccctgacc      900

tctggcgtgc acaccttccc tgccgtgctg cagtcctccg gcctgtactc cctgtcctcc      960

gtggtcacag tgccttcaag cagcctgggc acccagacct atatctgcaa cgtgaaccac     1020

aagccttcca acaccaaggt ggacaagcgg gtggagccta agtcctgcga caagacccac     1080

acctgtcctc cctgccctgc tcctgaactg ctgggcggcc cttctgtgtt cctgttccct     1140

ccaaagccca aggacaccct gatgatctcc cggacccctg aagtgacctg cgtggtggtg     1200

gccgtgtccc acgaggatcc tgaagtgaag ttcaattggt acgtggacgg cgtggaggtg     1260

cacaacgcca agaccaagcc tcgggaggaa cagtacaact ccacctaccg ggtggtgtcc     1320

gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg caaagtctcc     1380

aacaaggccc tggccgcccc tatcgaaaag acaatctcca aggccaaggg ccagcctagg     1440

gaaccccagg tgtacaccct gccacccagc cgggaggaaa tgaccaagaa ccaggtgtcc     1500

ctgacctgtc tggtcaaggg cttctaccct tccgatatcg ccgtggagtg ggagtctaac     1560

ggccagcctg agaacaacta caagaccacc cctcctgtgc tggactccga cggctccttc     1620

ttcctgtact ccaaactgac cgtggacaag tcccggtggc agcagggcaa cgtgttctcc     1680

tgctccgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gtccctgtct     1740

cccggcaag                                                             1749


<210> 55
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Lys Ala Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  


<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210> 58
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Lys Ala Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  


<210> 59
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210> 61
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Gln Leu Ser Val Gly Tyr 
1               5       


<210> 62
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Asp Thr Ser 
1           


<210> 63
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Gly Ser Gly Tyr Pro Phe 
1               5       


<210> 64
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Leu Ser Val Gly Tyr 
1               5   


<210> 65
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Asp Thr Ser 
1           


<210> 66
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210> 67
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 67
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210> 68
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 68
gacatccaga tgacccagag cccctccacc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacttgca aggcccagct gtccgtgggc tacatgcact ggtatcagca gaagcccggc      120

aaggccccta agctgctgat ctacgacacc tccaagctgg cctccggcgt gccctccaga      180

ttctccggct ctggctccgg caccgagttc accctgacca tctccagcct gcagcccgac      240

gacttcgcca cctactactg ttttcaaggc tccggctacc ccttcacctt cggcggaggc      300

accaagctgg aaatcaag                                                    318


<210> 69
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 70
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 70
gacatccaga tgacccagag cccctccacc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacttgca aggcccagct gtccgtgggc tacatgcact ggtatcagca gaagcccggc      120

aaggccccta agctgctgat ctacgacacc tccaagctgg cctccggcgt gccctccaga      180

ttctccggct ctggctccgg caccgagttc accctgacca tctccagcct gcagcccgac      240

gacttcgcca cctactactg ttttcaaggc tccggctacc ccttcacctt cggcggaggc      300

accaagctgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcataaggtg tacgcctgcg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210> 71
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (7)..(11)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (13)..(17)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (19)..(23)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (25)..(29)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (31)..(35)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (37)..(41)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (43)..(47)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (49)..(53)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (55)..(59)
<223> /note="This region may encompass 1-5 residues"
     
<220>
<221> MISC_FEATURE
<222> (1)..(60)
<223> /note="This sequence may encompass 0-10 '(Gly)n-Ser'
      repeating units where n=1-5"

<400> 71
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
    50                  55                  60  


<210> 72
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (7)..(11)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (13)..(17)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (19)..(23)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (25)..(29)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (31)..(35)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (37)..(41)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (43)..(47)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (49)..(53)
<223> /note="This region may encompass 1-5 residues"

<220>
<221> MISC_FEATURE
<222> (55)..(59)
<223> /note="This region may encompass 1-5 residues"
     
<220>
<221> MISC_FEATURE
<222> (1)..(60)
<223> /note="This sequence may encompass 0-10 '(Gly)n-Ala'
      repeating units where n=1-5"

<400> 72
Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ala Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ala Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ala 
        35                  40                  45              


Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ala 
    50                  55                  60  


<210> 73
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MISC_FEATURE
<222> (1)..(10)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (12)..(21)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (23)..(32)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (34)..(43)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (45)..(54)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (56)..(65)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (67)..(76)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (78)..(87)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (89)..(98)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (100)..(109)
<223> /note="This region may encompass 0-10 residues"
     
<220>
<221> MISC_FEATURE
<222> (1)..(110)
<223> /note="This sequence may encompass 1-10 '(Gly)n-Ser'
      repeating units where n=0-10"

<400> 73
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
            100                 105                 110 


<210> 74
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 74
Gly Gly Gly Gly Ser 
1               5   


<210> 75
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MISC_FEATURE
<222> (1)..(10)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (12)..(21)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (23)..(32)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (34)..(43)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (45)..(54)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (56)..(65)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (67)..(76)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (78)..(87)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (89)..(98)
<223> /note="This region may encompass 0-10 residues"

<220>
<221> MISC_FEATURE
<222> (100)..(109)
<223> /note="This region may encompass 0-10 residues"
     
<220>
<221> MISC_FEATURE
<222> (1)..(110)
<223> /note="This sequence may encompass 1-10 '(Gly)n-Ala'
      repeating units where n=0-10"

<400> 75
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala 
            100                 105                 110 


<210> 76
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 76
Gly Gly Gly Gly Ala 
1               5   


<210> 77
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Arg Gly Asp Ser 
1               


<210> 78
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 78
His His His His His His 
1               5       


