               SEQUENCE LISTING

<110> NATIONAL CHENG KUNG UNIVERSITY
      DCB-USA LLC

<120> ANTI-DENGUE VIRUS ANTIBODY, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USES THEREOF

<130> P2968-1-PCT

<150> US62509205
<151> 2017-05-22

<160> 18

<170> BiSSAP 1.3

<210> 1
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-CDRH1

<400> 1
Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn 
1               5                   10      

<210> 2
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-CDRH2

<400> 2
Phe Ile Ser Tyr Ser Gly Ser Ala Arg Tyr Asn Pro Ser Leu Ile Ser 
1               5                   10                  15      



<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-CDRH3

<400> 3
Ala Arg Val Glu Arg Leu Gly Tyr Phe Asp Val 
1               5                   10      

<210> 4
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-VH chain

<400> 4
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Phe Ile Ser Tyr Ser Gly Ser Ala Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Ile Ser Arg Thr Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Glu Arg Leu Gly Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Thr Val Thr Val Ser Ser 
        115             

<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-CDRL1

<400> 5
Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met His 
1               5                   10                  15  

<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-CDRL2

<400> 6
Ala Ala Ser Asn Leu Glu Ser 
1               5           

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-CDRL3

<400> 7
Gln Gln Ser Asn Glu Asp Pro Thr 
1               5               

<210> 8
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-VL chain

<400> 8
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Ser Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          
Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Phe 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      
Glu Asp Pro Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105                 110     

<210> 9
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthesized-VH chain

<400> 9
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc      60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag     120

tttccaggaa acaagctgga gtggatgggc ttcataagtt acagtggtag cgctaggtac     180

aatccatctc tcataagtcg aacctctatc actcgagaca catccaagaa ccagttcttc     240

ctgcacttga attctgtgac tactgaggac acagccatat attactgtgc gagagtggaa     300

cggctagggt acttcgatgt ctggggcgca gggaccacgg tcaccgtctc ctca           354


<210> 10
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthesized-VL chain

<400> 10
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggcctcc      60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gcactggtac     120

caacagaaac caggacagcc attcaaactc ctcatctatg ctgcatccaa tctagaatct     180

gggatcccag ccaggtttag tggcagtggg tctgggacag tcttcaccct caacatccat     240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgacg     300

ttcggtggag gcaccaggct ggaaatcaaa cgg                                  333


<210> 11
<211> 354
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-DENV NS1 antigen

<400> 11
Ser Gly Cys Val Val Ser Trp Lys Asn Lys Glu Leu Lys Cys Gly Ser 
1               5                   10                  15      
Gly Ile Phe Ile Thr Asp Asn Val His Thr Trp Thr Glu Gln Tyr Lys 
            20                  25                  30          
Phe Gln Pro Glu Ser Pro Ser Lys Leu Ala Ser Ala Ile Gln Lys Ala 
        35                  40                  45              
His Glu Glu Gly Ile Cys Gly Ile Arg Ser Val Thr Arg Leu Glu Asn 
    50                  55                  60                  
Leu Met Trp Lys Gln Ile Thr Pro Glu Leu Asn His Ile Leu Ser Glu 
65                  70                  75                  80  
Asn Glu Val Lys Leu Thr Ile Met Thr Gly Asp Ile Lys Gly Ile Met 
                85                  90                  95      
Gln Ala Gly Lys Arg Ser Leu Arg Pro Gln Pro Thr Glu Leu Lys Tyr 
            100                 105                 110         
Ser Trp Lys Ala Trp Gly Lys Ala Lys Met Leu Ser Thr Glu Leu His 
        115                 120                 125             
Asn His Thr Phe Leu Ile Asp Gly Pro Glu Thr Ala Glu Cys Pro Asn 
    130                 135                 140                 
Thr Asn Arg Ala Trp Asn Ser Leu Glu Val Glu Asp Tyr Gly Phe Gly 
145                 150                 155                 160 
Val Phe Thr Thr Asn Ile Trp Leu Lys Leu Lys Glu Arg Gln Asp Val 
                165                 170                 175     
Phe Cys Asp Ser Lys Leu Met Ser Ala Ala Ile Lys Asp Asn Arg Ala 
            180                 185                 190         
Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Ala Leu Asn Asp Thr 
        195                 200                 205             
Trp Lys Ile Glu Lys Ala Ser Phe Ile Glu Val Lys Ser Cys His Trp 
    210                 215                 220                 
Pro Lys Ser His Thr Leu Trp Ser Asn Gly Val Leu Glu Ser Glu Met 
225                 230                 235                 240 
Ile Ile Pro Lys Asn Phe Ala Gly Pro Val Ser Gln His Asn Tyr Arg 
                245                 250                 255     
Pro Gly Tyr His Thr Gln Thr Ala Gly Pro Trp His Leu Gly Lys Leu 
            260                 265                 270         
Glu Met Asp Phe Asp Phe Cys Glu Gly Thr Thr Val Val Val Thr Glu 
        275                 280                 285             
Asp Cys Gly Asn Arg Gly Pro Ser Leu Arg Thr Thr Thr Ala Ser Gly 
    290                 295                 300                 
Lys Leu Ile Thr Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro Leu 
305                 310                 315                 320 
Arg Tyr Arg Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro 
                325                 330                 335     
Leu Lys Glu Lys Glu Glu Asn Leu Val Asn Ser Leu Val Thr Ala Gly 
            340                 345                 350         
His Gly 
        

<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized

<400> 12
Tyr Lys Asp Trp Ser Glu Trp Gly Lys Ala Cys 
1               5                   10      

<210> 13
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthesized-CDRH1

<400> 13
ggctactcaa tcaccagtga ttatgcctgg aac                                  33


<210> 14
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthesized-CDRH2

<400> 14
ttcataagtt acagtggtag cgctaggtac aatccatctc tcataagt                  48


<210> 15
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthesized-CDRH3

<400> 15
gcgagagtgg aacggctagg gtacttcgat gtc                                  33


<210> 16
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized-CDRL1

<400> 16
Ala Ala Gly Gly Cys Cys Ala Gly Cys Cys Ala Ala Ala Gly Thr Gly 
1               5                   10                  15      
Thr Thr Gly Ala Thr Thr Ala Thr Gly Ala Thr Gly Gly Thr Gly Ala 
            20                  25                  30          
Thr Ala Gly Thr Thr Ala Thr Ala Thr Gly Cys Ala Cys 
        35                  40                  45  

<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthesized-CDRL2

<400> 17
gctgcatcca atctagaatc t                                              21


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthesized-CDRL3

<400> 18
cagcaaagta atgaggatcc gacg                                           24


