                         SEQUENCE LISTING

<110>  NEW YORK STEM CELL FOUNDATION, INC.
       ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
       NOGGLE, Scott
       ORTIZ-VIRUMBRALES, Maitane
       GANDY, Sam
       KRUGLIKOV, Ilya
       EHRLICH, Michelle
 
<120>  METHOD AND COMPOSITION FOR GENERATING BASAL FOREBRAIN CHOLINERGIC
        NEURONS (BFCNS)

<130>  NYSC1390-4WO

<150>  US 62/511,271
<151>  2017-05-25

<150>  US 62/571,741
<151>  2017-10-12

<150>  US 62/574,639
<151>  2017-10-19

<150>  US 62/586,571
<151>  2017-11-15

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  33258
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  chromosome 1, GRCh38.p12 Primary Assembly

<400>  1
ggggcctggg ccggcgccgg gtccggccgg gcgctcagcc agctgcgtaa actccgctgg       60

agcgcggcgg cagagcaggt gagcgggcgg tgccgggggg tgcccaggcc agggccctgt      120

cgcctgcggc gctgagggcc cggggtgggg ctgcgccctg agggccctgc cctgccctcc      180

gcacgcctct ggccacggtc ccttccccgg ctgtgggtct gcggcccctg cgtgcgcagc      240

gctcctggcc tctgcggcca gcgcgggggc ggagagagga gagtgcccgg caggcggcgg      300

ctgggccggc ccggaactgg gtcgtggaag gatcgcgggg agcggccctc aggccttcgg      360

cctcactgcg tccccacttc cctgcgcccg cctgccgccg agccccggct gggggtgggc      420

gcggcgcgag cggttaaagg gccggtgcat ttaaaggagc ggtgcacgtg ggtctctgag      480

gcgtgtagca ggcgggggcg ttttgttctt cttctctctc gccggagacc tccgttgcgc      540

cgagtccatt cggcctctag caccgggtcc tgggcatgct ttccccggga aggaggcgcg      600

cgggggctct gcccgcacgt gaggggcagg gccgcaggct caagcctaga gccggtttct      660

gttagcagcg gtgtttggct gttttatcag gcatttccag cagtgaggag acagccagaa      720

gcaagctttt ggagctgaag gaacctgaga cagaagctag tcccccctct gaattttact      780

gatgaagaaa ctgaggccac agagctaaag tgacttttcc caaggtcgcc caggtacgat      840

atagcagagc caggcttcga ccccagtgtc ctggcttcta gatctgctgt ccatccctcc      900

gagcagacct cacccctgtt tattgcctta ataagtattc cctttgaaag gtatgaacgg      960

tgttgagtga agtaactgca tccctattta caaatggaga acctgagagc attccataga     1020

gacgattgta gactaactta actcagaagc gacagcctgg ggttgccaag gctgtctacg     1080

aagtaacttg attaggaccg accccagctt ccagtaagga agcctctgat gcctctgtag     1140

ccaattctgc agacacctga gcctccaagg ccttcagcca agacctttgg cggtaattgg     1200

agtctcggga taagctgctt caggtgtgtg agcctcaggt tcttctctcc tgaatgtggt     1260

tgtgggcagc cggtgactgg cgcaggtgca gaaggggcct ggttcttggc cccacctcag     1320

agctgcgtcc tcacgacgcc cacgttgagc cttgggttcc agggcagaga ctggagtgag     1380

ggcttggggg catgttgctt tgaagtggga tggatgtatc aggtttttgg ggaaaactct     1440

gtaccctttg gtgttgaagt gcccatgtgc caagtcttga gtccagcatg ttcacatgtg     1500

gggagtgagt ggcttgttcc tgtctatttg aaagagcagc aaggaggagg aggagcaagg     1560

gctaggggct gctgctgggg tgcctggagc tgtggtgcat aatgtcacac ctgtctcccc     1620

tccgtagctg ctcaccgtcc ccccaagggg ggtttgcctc ttgcctactt tggcctttct     1680

ctgttatcga tgttaataat gacatatatc tcgcttatga gttggtcata ataaaaagct     1740

atcttgtaca gaatattaga atttaagatc ttaagaattt caatgacact gaaatagttt     1800

attattacct ttttacagaa gaggaaacaa gttcagggag ttaagcagct agtccagtta     1860

tgtggcttca gtgctttaag caccaggatt tgaacatagc tggctacact gtctttatct     1920

cttgagtttt tgcgcaggag gttcctgtat tcaactccta cccgtgtctc tccactactg     1980

ctgggaaagt tttgtggagt ccccatgagc aacttcctga caaacaaaca aaattttttt     2040

aaagaaacca aagcagtgtg tgtaggtcac atgcagtgtg tctaatgaaa acatctctgg     2100

cgggttttca gctgttgctt tgactttcgg acactgttta gttggggact gataagacag     2160

caaatatttc tgcaagtatt cccacctgtt ctattcccag ctgccacagc tgcggaaagg     2220

cgggggtgag gctgagaggc cccgagagga acattttcca ctgggctcca atcctggaga     2280

tgggatgacc atcatgttaa tgtctggaga aaagaatgat ttcaggctgg gtgctgtggc     2340

tcatgtctgt aatcccagca ctttgggagg ccgaggtggg tggatcacct gaggtcggaa     2400

gtttgagacc agcctgacca acatggagaa accccatctt tactaaaaat acaaaattag     2460

ccgggcgtgg tggcacatgc ctgtaatccc agctactcag gaggctgagg caggagaatc     2520

gcttgaaccc aggaggcgga ggttgcagtg agccgagatc gggccatggc actccagcct     2580

gggcaacaag agcaaaactc catctcaaaa aaaaaaaaat ggtttcacat cagtcctcag     2640

gaaagatcag atgtcagtga gggagatcat ttcttgagag cctcttcact gagtgggaga     2700

atgggctgct tgttcatctt tgtgaaaatt ctagaacggg aagaacaatt caaagggtgt     2760

ccaccattct gctgtacctt aaccagaaac ttactggact ctttttaaaa taaaagtaat     2820

tcatgtttat tctagaaaat tagggaaaaa aaattttttt tgagatggag tttcactctt     2880

gttgcccagg ctggagtgcg atggtatgat ctcagctaac tgcaacctct gcttgccggg     2940

ttctagcgac tctcctgcct cagcctcctg ggtagctggg attacaggtg cctgccacca     3000

ctcccagcta atttttgtat ttttattaga ggcggggttt caccatgttg gccaggctgg     3060

tctcaaactc ctgacctcag gtgatccgcc aaccttggcc tcccaaaatg ctggtattac     3120

aagcataagc cattgcgctg ggctgagata accactctta acatgcattt ccttccacac     3180

tgttcacata tgcatattta tctattaaaa caatagaggg agggaaccgt aggtgaagtt     3240

tgtgtatcct gttttttctg ttatgccttc agaattttcc ttttattgag tactcatgga     3300

aaagcagatt tgatggctgt gtagagcatt tgaattattt atcctaccag tcccacagca     3360

ggacactttc ccaccctccc ttttgcccca gagaagcagt gccctctgtc ctccccatgc     3420

ccatatgtgg gcactcccca ccatggagcc aaacctacct gggcaagtag cagagggaga     3480

gcagagtgag ccctgggggc aggagagaga cttgagagtt ttgaggtgac agatgagctg     3540

gtgagtgagt gattagggag catttcttga cacatacctg cccgtggtga aggcatgtgt     3600

cttgtgagtg tgctcccaga aagcctgtgt agtgtgtggt gggcctgcct gtgtgaccaa     3660

accctggcca ctgggtacgt gaccctcaca agtgctgact gggctgagaa gagctccttg     3720

atgggcagtt tggagacttg agttgtaact gtggcttttg gccatgggac attaactgat     3780

tacttttgcc cctctaggct tcagttgtcc ttaattataa tacagggagc tgactaggtg     3840

gcgttgatgg cctttacggt ccttgccagc tctgacattg tcctatggat atgtcctttc     3900

atttgataat atgtttacgt ggccatagtg cctggggctg ggccgggaat ggaaacttga     3960

tctctggggc ctggcctttg aagccagttc atgtgtctgg tggttcagca gatccgtaac     4020

tttccaagag gcacatccat aggctaccgt gtcctttctc actgtgtccc tcctccattt     4080

catcttcttt ataactacga cttattgaac atctactgtg tgctggacac tttacaggtt     4140

atctctaggt tttacgataa tcttgcaagg tatgcctgtt ctgcttttta cagcagagga     4200

aatgagctgt gtcagattag actgtctgag gcctcttggc cagggagtat gtggttcaaa     4260

tcacataggc aggcgatctg aaccctgtca gtctccaaag cctctgcttt tgaccgctga     4320

cttgctgctg cttgtttaaa aataaatgtg tttctggagc ctactccaga ggggcgtgct     4380

aggggctccc tctcccactt ccccacaaac cacccttttc cctggctgct tcaggaaatg     4440

agagaactct gcctgggccc caggcacttc tgagtgggac agggctgtta gaggtaagtc     4500

tagagcctgg cccaaaattc aggaggcccc atcagagggc ccctggggcc tgtggtccgg     4560

gagggtggta gggcagtacc tcacttccct ttgagactca ggccccagct ctggcttagg     4620

ccagggagaa ccatccccaa gtggtatgtg ttactatatg agctgagatg gatggtcagc     4680

tggaccaaat acatagtcgg gtacccaggg ccagggggag gaaggtgagc agggaagctg     4740

tgggcaattg tctgggtatc acctgacctt agcaaactct tccttgtttt aagcgaggac     4800

gtgggacttc tcagacgtca ggagagtgat gtgagggagc tgtgtgacca tagaaagtga     4860

cgtgttaaaa accagcgctg ccctctttga aagccaggga gcatcattca tttagcctgc     4920

tgagaagaag aaaccaagtg tccgggattc agacctctct gcggccccaa gtgttcgtgg     4980

taagtgcagt gactcccaac ctgcttttga accctctttt tccattagga ttttctccgt     5040

ggaggcagat ttccatggga gtttgctgtg gcattttgaa atctgtttct tacctagttc     5100

cattggcctt aaatgttaag gccaaagcct ttacatttct ctgtaatgaa aagaaggtcg     5160

aggaaattgg gtcattgggt ttccataatg attgcaggaa ctgctgacac aagcacggct     5220

ggggagattc tctaggtcag actcccttgg tttggctaat tcagcagttt gatcccattc     5280

agctgattaa tgggaatgtg cagtggcttc tttggatgtt tgattttgca tcctaatcca     5340

aagcagctat cagcctcagc acttccttgt tggaaggctt tccagaacgt agtctatgtt     5400

ggacacttcc ttctgcctct ctgcattttc ctgccacttc tctagagaat ggggtgcagg     5460

gggtgggaga cggggaaagc tggtcgctga gtggctgatg ggacttgaca tcacccagcc     5520

ccacccccac ctgcccgtga gtcagcctcc ggggagagtt catcgcgtca ccggcactct     5580

aatgtggaca gacacctagc agtgttgttt atctgcacac gtttgggtgg tgatttttcc     5640

ctccaaggat ttcagagcac cagcaggctt cagagcagac ttaggtggct tgcaaagcag     5700

gccctcagga attcagaggg tagcagaagt ccatcccaga tgctctgttt tccttcagga     5760

gctaggtaaa tcagaggggc tgagggacaa atgaaaaaag ttacagcctt tgagtcccat     5820

ctgctcctcc tggccaatga gaggggatct gggaggggca gatgtagagg aaaatctgtc     5880

taaatgttga tgctcgttat tttcctttaa agaattaata gcctaaaata aaccctacag     5940

atacagtctg tgtttattat ggcgacttag agaaatgcag aaaaatatca agaaaataaa     6000

aaccactctt ggttctacca tgcaaagata atcatcttta atgttttgta atatttccga     6060

tcttttatat acatacattt tataaggaca ttcagatgat caggttcgta aagttttatg     6120

ttcggttaaa tttaacagcg tgtcattgtt caggttatta aatgtttgaa ataagatttt     6180

tggtggtcct gtcacagtct ccatgaagta gcatttcagg atcgaaaggt atgctgtgtt     6240

taaagtgttg attcttactc ctttcagtta aggccagtgc agtttgtcca ggtagtgact     6300

gagacccagt ttttccacac tctcctccgc agtgggcatt gttttgggcc tttttcagcc     6360

caagagctct cttctcccca tgccgctctg ctggtctgag atttttccac tcctcctcct     6420

ccctagttgc tctctgacca gactctaggt attcaggaga aagtgttcat tgtctcactc     6480

tctcatgtgg caatcaagta gtgccaagca gtgagagggt gaaggtgggt gggtgaggga     6540

cactcacctt gctgagaaag ggccccagcc tgttcgggtg attataaagc agagacagtg     6600

ccaggaaaag tctgacactg gctgagaatc acccggggac caaccatccc gaatgcggat     6660

ccctgacact gggtgaggat ggagcttgga gatctgcatt gttaataagc agcctagcag     6720

agtggtgaag agtccagaca cactacctag gtccaagggt aaccttgagc taattacttt     6780

ttgagcctct gtttcctcat cagtaccatg gggaagaata gtagcacctt gctccaggat     6840

gtttagtgcc ggctaagggc tcagcaggtg ctggtccatc tccaccagcc cccagtggcc     6900

tgggccacct ttgagaaaca gtgatcctaa gggattcagc atttcctaag ttggtgcctc     6960

ccacctgtca cccccacccc accaggctag gagggttgtg attagagggt gcccttgctg     7020

tgacagctga gactagctct tccctgatta ttccttaatg acagctctct ccttccctgc     7080

tttcttgaag tcttggtcct cgttgttgtg ggcacagctt caggggaggc cttggaggaa     7140

tttttgaaag tggaatgagg gaagcagcct gctcaaggga acacttgttt tctggtgagg     7200

aggccgcatg tatgaatgac gtttgtgggt tagaaagcat gttttgtagt ttttccttgt     7260

ttcttcctga agacatgtca ggtcttgatg agaccgggcc tgggcacagg gcaggcagtc     7320

agcgagtgtg gatgatgacg acagtggtca ccaggtcact gtctagacca ggtcactgtc     7380

tagcgcagtg tcacatggaa agggtatggt cctttaaccc taccctcccc agcacaacta     7440

tcacagatgt cagggaacct ctgctcacag aactgctttc cagggattgt cttttttttc     7500

tttttctttt tctttctttt ttttttgaga cagagtctca ctctgtcgcc caggctgaag     7560

tgcagtggtg cgatctcagc tcactgcagc ctccgcctcc tgggttcaag tgattatctt     7620

gctacagcct tctgagtagc tgggattaca ggtgcctgcc accatgtcca gctaattttt     7680

gtatttttat tagagacggg gtttccccat gttggctagg ctggtcttga actcctgacc     7740

tcaggtgatc tgcccacctc agacaggcat gagcaccgca cccagcccca gggagcgtct     7800

tattagtggt tggcaactga atggagacgt gggaattgta aggaactgat tctacttgat     7860

cctgggtccc ctgcttctcc atcttcaccc acccatcagc tccctttctc ctttaaacag     7920

gcacctttgc tctctgctta tccatttttg ttgtgcattg ctatttggga gcctaagaaa     7980

cacaacatcc tctgaatgct ccagctgttg tgggtctgaa gggtgagcct gccctctgtc     8040

attggaggct gcagcctgtg gctttttagg tacagggact cccagaactg ctcctccagt     8100

catagcagag ataaatcaca ggagcttaag aggcatggga agaacagagg gaggagatcg     8160

tagcttccct gttcattcac acccaaaaca aaactgtcat actagaaaag gaggtattaa     8220

aagagccacc tgtacagcct cgtatctcat ccagcacact gctgcagatg gaatattatg     8280

atttagcttg agaaaatgca gcaactcttt gttgtggtgc ccctctttga gtaagagtga     8340

attccccatt gccagagtgg atagtgaggg aaaccctggg tccaggcagg agtctgttta     8400

ggatttatct agtgaggctg agccagagga ggaccttaca gttttttctc ttcaatttct     8460

tttatttatt tatttatttt tgtagagatg gggttttgcc atgttaccca ggctggtctt     8520

gaactcctgg gctcaagcga tctgtctgcc tcagcctccc aaactgttgg gattacaggc     8580

gtgagccgag ccaccatacc cggcccttct cctgcatttc cacctgataa tttctctcat     8640

ttccatagat gatgaaggaa ctaaagccaa gaactttcca aggtcctgca gctctttggg     8700

ggatgtgaag ctgtgctcta tttgtatgga ttttgctggt tcccagaact tccctgtggc     8760

cctggggcct agtctgaggg tactctgagt gaagagggag gagggcccac acctcttctg     8820

caaaggctgc ttttgtaaag ttcacttcag ttcacatctt cctcctggtc agaaagcttc     8880

gggggctctc ctctgctgca ttaagctctt actcctccat caggcaccaa actcctccct     8940

ggcatggccc atcctaccag gtccccacac ttgagccaca tccaattgct cgatattatc     9000

aggataggtt atgttatgtt cccaactcat atgtttactt aagtggttac ctctttccag     9060

aatgagcccc ctcctccaaa ctctgcctgg tgaaatattc ctaacctttg cagcttcaca     9120

tccctcttac ttcttgtgac ctgaggcatc tactcctgac aactgataga ctgtgtcccc     9180

tcctgtcggg tgcattgtcc ttgtcactac cctcctggct tttagctggc tttgcttccc     9240

gctgttgtta ctcctgtact tgtctcatct atcctaaaca gaaggtgctg caggctgggg     9300

agtttgttca tgttgaaatc cctgtgatgg aggtgagcag aggcagtctc tgcctgtgcc     9360

tcttatttgg ggatgaagtt aaagtccctg taggaataat ccaggccata gccggggttg     9420

ctgtcttcag aaagaagggc agccacaggt cttgttaagg ggattgaaat tggctgactt     9480

ggtggaagga acctgcctgc tttgtttaaa aaccacatat agctgagtgt agtggttcac     9540

actctgtaat accagtgctt tgggaggctg aggcaggagg atcacttgag gccaggagtt     9600

tgagactagc ttgggcaaca acgtgagacc ctcatttcta caaaatattt taaaaattag     9660

cctagtatgg tggcgtgcat ctgcagccct agctactgag gaggctgaag tgggagaatt     9720

gcttgaaccc aggagttcaa ggctgcagtg agctatgatt gcaccactgt actccaacgt     9780

aagtgaccag tgagaccctg tctctagaaa taaaaataaa aaaaatcaca tatattgtgg     9840

ggtgacttac ttggagacga actttcagca gagcgcacac ctgctatccc tgcccagggt     9900

gtgaagctca gccctgaggg tctctggaca gcgatcactc agcctctgga cagcgatcac     9960

tcagcctctg gacagacagc gatcactcag cctctggaca gcgatcactc agcctctgga    10020

cagcgatcac tcagcctctg gacagcgata actcagcctc tgtccccgtc tgagatgttg    10080

gcagggactg tcagatttgc caggcattgt ttgaagttct tcccagccca gaaacctgca    10140

tgtgtagatt ttggtacact gggtccccca cttggtacta ctgtgtgaaa ccccacttgg    10200

cactgtttta gggggcaggc ttccctcctg tccccttggc cttggccttc ccctgggtcc    10260

cgccctcagt ggcacttccc cacctcacac gtctgctctc atggcttagg tctccacttc    10320

taacctcagg agacctggtc ctcagacacc tcccagacag cttccccatt ttatcccata    10380

gacactcaaa gggtgaaatt catggtcttt cccgagactc tcttctccgg tcttccctgt    10440

cttagtcccc acctggctgc cattctagac tgtgttttct ctcctgcgtc aggtcctgcc    10500

cttgacctct tgaccccttc tggactctgc cctcacttgc atccatcctg ctgctgtcct    10560

cagctctcct cacctgccac agttgtctct gggggtcact ttccctctct ggtcagtggc    10620

cagactgact tttataaacc tggttcagat cttgtctgtc aagattgtcc tcagggtgat    10680

gtgtgtctcc ttaacatggt gcctgagacc ctgatcatct ccactgcccg ccccacagtg    10740

tgaggccctc actggaacat tgtgccttct gcccttccct cctcctggga aaaccagtct    10800

ccatcagata ggctcttctc tagaaaacat tcgtgatctc tgagatttgg ttccactttt    10860

gtgcttctgc acctaccatc aaacacccgg attgtatcat ttgtcacatt agatgatttt    10920

tgttttgttt taagacaagg gtgtttctta ctcatctttt tatccccaga gcccagcatg    10980

atctttggtg cataatagat gcaccacaga tgtttgctga ttgaatgaat gagcacactg    11040

acagtttgga gctgccctga ctttcgtggc tatgcgtttt gccccctggg atgtgagtca    11100

cctcaggcca gccccaggca aggccgctgc tgcctccatg gtaactctca aggcctcttg    11160

ttttatggca gtcgtttgat tgacaggcat ctcttggaag cttttggggc aggacttgtg    11220

tccaagtctc caggtcgcct ccagccaccc cctgagtcct ccactgcctt tgtctcacag    11280

gaaagtggaa caaggtcctt gtgctccttt ttccaggtgc ttccagaggc agggctatgc    11340

tcacattcat ggcctctgac agcgaggaag aagtgtgtga tgagcggacg tccctaatgt    11400

cggctgagag ccccacgccg cgctcctgcc aggagggcag gcagggccca gaggatggag    11460

agaacactgc ccagtgggta ggtcccacca gcagctgggg gccttcaaac aggtccctgc    11520

ggctactgta ccttacagat gaaaaccaga cattcattcc ctgatgcggg agggagaagg    11580

gaagtaatga tgaggattgg ccgaaaaggt gggtggctgg ccatgatgga ccttccatct    11640

gcagggtttc ataggactgc gcattcacag ccagagatgg acttggcagt gggctgaagg    11700

acgctgtcca ctctgccacc ttgggtttac ctctctcatg caggtcactg tttccactgt    11760

aataggagag tttgtttgga tgcctgggtg ctaggacagg taacacagaa gcttaggatg    11820

gtagcagggg aagcattttt tggcagatgg ccagacatgg taagtgtgag aggagtctgc    11880

ctgatacacg attgactttt gagctgggga tatttgggct tcactgtgat cattcagccc    11940

ccaggggagg agattgtaac gttagaaaga gtaggatatc gttgggagag ccacttagtt    12000

gtgtcctttc tctcccgatc agggcagaac atctgaattt gcctgaaccc tgttctctgt    12060

tttgcccatt atagaattaa aaaatgtctc tgtgtggact gttttcttgc agccagtctt    12120

aatcctgctt gctgaaattt gagctcactt ctccatgttc tccttgagaa cggaaccatc    12180

gtccctaagc cctgagtgaa atcacaccag cttaaggcca ctgctctgcc actcctcagc    12240

cttttcttgt ttgttatctc cgggaagttt tgtacacttt ggttgtttca gtttctgttc    12300

atgagtagtc ttctttcttg gctgaacgtc tagattggga ctctctctgc agagaaccgg    12360

tactgaagca actgtcattt tcagtttttg tttcatttgg ctttttcttt agctgttcac    12420

ctcattagca aggcagccca tgaccttgac ttgccacagt tccaaaacac aaattcttac    12480

agatcggttt gtgctagtgt ctggcaggtg tcctgccctc cctcgttacc tcctcatttg    12540

tgcctgccca ccttcccaga gcctgcgtct tctcagatgc ttaacacctg tttagcctct    12600

ctagttcaga gctacaaatt tacatgcttg attctgtggg gcagaaagtt caaagtaatt    12660

tcttcctctg caaattccca gtatcttagt cacacgcaaa gagagtgtcc ctgtgcactg    12720

actcctctag ctagtgattt gtcagccaaa aatgtttatt tatctcctgg cctgtttcct    12780

cccatatcag tatggccaca tgaacagaat tgagtgacct cctgagtccc tgtattagga    12840

aggggaaaga tcttttgatt cattaaccat taagttgatt cattaaccat taagtcttgg    12900

gcctgcagac catagcaacc ttccttcctt catttatggt gcttcatcca gctccaaatc    12960

ttctctactt tgtcctcaca aacttttcat atgccctagt agctcataga ctgctcctta    13020

tatctggaaa gcaacattca aacttctcat ttctggttcc aaaaatccgt gcattacatg    13080

gataggctgc cgtgggggac attctgcggc cctcacgatg tggtttccca cagagaagcc    13140

aggagaacga ggaggacggt gaggaggacc ctgaccgcta tgtctgtagt ggggttcccg    13200

ggcggccgcc aggcctggag gaagagctga ccctcaaata cggagcgaag cacgtgatca    13260

tgctgtttgt gcctgtcact ctgtgcatga tcgtggtggt agccaccatc aagtctgtgc    13320

gcttctacac agagaagaat ggacagctgt gagttggggg gctgggggga gcagggtggg    13380

gtgagggctg agttgccagg gggtgggggg cgcagcagcc tgtgttggtc actgtacctg    13440

cagctccaca ccagcagcgg taaagagcag ggatgaagaa ccgcccaggt tcatggcctg    13500

gctcactgcc tcctggattg tgacctactt gggcatgctt ttaacatccc tatgcctcag    13560

cttccttgtt cgtataatgg gttgataacg cagttactgg gagaattaag tgagttaata    13620

tgagtgaagg gcttagaaga gtgtctactg cacgtgagtg ctcaggcaag ctggatcctg    13680

ctgcagaaag caagctcttg atcctgggca tggctgtgcc actgatccct gtgtgactgc    13740

aaacaaatca cttcctctct gagtctctgc ttccctgaat gtgaaacaag gtggttggac    13800

cagatatttc tcagctcact tccagccttg tgaggaagac ttataaagcc tttcgtttat    13860

tttagtaaaa tacatgcaga ggcagcagcg tagaaaaatg agaagcttcc tccacttctt    13920

ccccctcccc tttctgtggt cctcactgct aagcaccttc tgtaaacttt tttttttttt    13980

tttaaagtta gggatttttg tttcatttcg tgtgtgttgg ttttttttgt tgttgttgtt    14040

tcttttaaag aaaggaataa ggccaggtgt ggtgtctcat gcctgtaatc ccagcacttt    14100

gggagactga ggtgagagga ttatttgagc ccaggagttt gagaccagcc tgggaaatgt    14160

ggcgagaccc tgtctgtaca aaaaatgcaa aaattagcca ggtgtggtgg tacatgcctg    14220

tagtctcagc tacttgggag actgaggtgg aagaacacct gagcccagaa gtcgaggctg    14280

cagtgagcca tgattgcgcc actgcactgc agcctcagca acagagtgag accctgtctc    14340

aaaatttttt taaaaaatta aaaaagaagt agagtcccat cctcagaaag cttatagtgt    14400

gtgggggatt cagcgcagaa caggtgaaag catggagaga atgcagccag cggtttgttt    14460

gcagcagtcc aggctgggaa gagtgaggtt tgagtgaatt gcttcctgtg tctgcttcct    14520

gagcttatga gctgcaagga cagcagttgc ttcagcggat gggggtcggg tagtagcagg    14580

tggaggagtg ctgggctggg tggagctggt ggagaggtgt gggtgggtgg gggaatgaga    14640

actggatggg tgagagaagt gcctagggag cctttaatcc ctgtgggggt ggggaaagca    14700

gcagggaggt catctagccc tcgtcctcac tgctgcactg ggcccagttg gcaggctgag    14760

agccacaggt ctgtggtcag ggtgccagga aatgagctgg aggacaggaa ctgctcatgg    14820

ggatggtgcc cgcactccat cagggcagca tgtgggcagc atgggcatcc caggcacctc    14880

ccctagcagg tccagaatca ctcaaggtgg ggagcctcga ggagcagtca gggccgggag    14940

catcagccct ttgccttctc cctcagcatc tacacgccat tcactgagga cacaccctcg    15000

gtgggccagc gcctcctcaa ctccgtgctg aacaccctca tcatgatcag cgtcatcgtg    15060

gttatgacca tcttcttggt ggtgctctac aagtaccgct gctacaaggt gaggccctgg    15120

ccctgccctc cagccacgct tctctccgtc tgccccacac catggcggca gggcccgtga    15180

aacagccgcc tttagaaaaa cacaaattag aggaaaatag acccagattt tttgtactcc    15240

tccccacccc atcctgtctc ccaccgtgga tgacctaata ctgttgtctt ttatttttat    15300

ttattttctt tttcttgaaa catggtctca ctccattgcc caggctggag tgcagtggtg    15360

cgatcatgac tcactgcagc ctcaacctcc tgggctcaag ttctcccacc cagcccctca    15420

agtagctagg actacaggtt tgcaccacca tacctggcta attaaaaaat ttttttttgt    15480

gcaggctaga tctcacagtg ttgcccaggc tggtctcaaa ctcctggact caagtgatct    15540

cccaccttgg cctcccaaag ttctgggatt acatgtgtga gccattgcat ccagcctgtt    15600

gtcttttaaa tttacacatt atcccacttg agttcctcat tgcagtgttc caagcatcat    15660

ttctcatatt tcaaagttaa ttttgttttg cttctctttc tgaagttcta ttttaggctc    15720

ccctcacccc gatacttccc ctgaagattt atttttagtt ttccttttcc ttttcgggca    15780

aggatgtgca gaggccatgc tgaggtcttg cagccctggg agacttttgg gttgtagctg    15840

cctatagctg ccgagtagcc ccagggagta gtggaagggc agatcccatc tggccagaat    15900

catgggcact gcctgtcccc aaagatgcca taagctttta gacagcggct tcaggctttt    15960

ctcccaggta aggggttgaa cccctaacga tggaaaggaa attaagctgg gcattaccta    16020

ttttaaaact gtttacacac aggtgcctca cagcattttt tgttcaggcc gctgccatcc    16080

atggagcagg tagatagaag tgcagagtgc ccaggctaga gggatgggac agggacagtg    16140

cagggaggga gctgagcccc cttccagcgg gggcagcaga ggggaaagcc atgggagggg    16200

ctgcaggatg tgtcctgagc tgaagcttat caacaagtaa tgagtaccag ctgggcattg    16260

tggtgcacgc ctgtggtccc aactacttgg gagactgagg caggaggatc gcctgacccc    16320

aggagttcaa gtctagcctg ggcaatgtaa gaccctgtct ctaaaaaaat aataataaaa    16380

taagtaacaa ttacctgtgt aactgtgacg aggcagggtt tgaacattgc cgctgggagg    16440

ttggcagatg gtgggaagca gggtggaggg ctgctggttt ggagcagagg atacagattg    16500

catggggtca agctagaaat tgcgtggcag atgtgaagag ctggccccac tgcgggcagt    16560

aggtgtctgg tggccagtcc cagaggctgt gaagaggggc tcagccatct gtctagtagg    16620

gcttccttgg aggttccacg atacaggcag atggtggtgg cccgggcagc caggtggtgg    16680

ctgggatgaa gagggttggc aggtcccaga ggcagcccct tccccttttg gctgtgtgtg    16740

cagcagggcc gtggaggctg cttttagtcc aggtagacca gggccacgct gaggtcccag    16800

tgggctgagc tggtgactga tgagttggtc ctcaggggtg aggctggtgg gaagtgatgt    16860

cactgtcccg ccgatggcca gctaagggac tgggttagga tcagccccct cttgtccttc    16920

actctcccat ccttggccag gagaagagga acaggtcttt ctgaggacct gcttgtagac    16980

ctttgggtag gaggggactt cccaggttct ctgttgaggc cactctatct aaaatagcac    17040

cccagtgagt ctcctatcac tgtatcctaa cattattttc tccatggccc tcatcattac    17100

ctgctgatat actgtatgtt tgtctatatg tcatctaaca cccctcacac tggaacacaa    17160

tgcccgtggg cagagacttt gctagccttg gttccagagc ctagaacagt gcctggcaag    17220

taggagacac ccagcattac ctttctaagt gaaccagtag agatgggggg agaccgcaag    17280

gctatgccgg cagacctgag ggagtcctgt ctgcatgcgc tgcaggatga cctgagggga    17340

actccttgga cttctgtgcc ctctttatct gtaaggtggc cacctgatcc cttccagcgt    17400

aggcatgaag tagcctaatg aagagcattc aggcttgggt atcagtctca ggatcctggg    17460

ggccttagaa tttgtggcgc ttggggacac cttgtgatcg tgcaatttct gttgtctagt    17520

tcatccatgg ctggttgatc atgtcttcac tgatgctgct gttcctcttc acctatatct    17580

accttgggta agtgacagat aagcagcagg gtccctggga gcccctctcc atgtggcaca    17640

agtggacatg ggcatgagga cctgggcggg gaaagatgac catcgagctc cagtcttccc    17700

cagtgccagc cgttttggga acccaggcct ccgtcgccct ctctcatggc cttgacacag    17760

gggagtggaa gtggggctgc atggtggacc acatgtttct gtctcgttcc tgatttaaaa    17820

tgaacccttc atggagaagg ctctctgtga accccagggg gatagaaacc ccccaaaatt    17880

tacattctga tttttaggct aggcctgggt actttctggt ttgtgggaaa aattatctgt    17940

tctatcgccc cttgatttgg gatatcagcc tgacccaggg gcccaaagag actgggagga    18000

caagagaaaa cactttccca aggacctttc catgtgcaca gggtcttcca ggtcatgccc    18060

atgcacattt ctgtgatctg ttccaagcat ccccaccttg ttttagaaaa tgctgcaaat    18120

ggtaaattgt aaggacagtg aaggtcgggg aaggaaatgt tagtaaagag ggccaggttg    18180

ggactgaatg gtggtaaact gctaggctgt aatgcctcca ctgagtccca gtcacaggct    18240

ccaccttggt cctgcaggga agtgctcaag acctacaatg tggccatgga ctaccccacc    18300

ctcttgctga ctgtctggaa cttcggggca gtgggcatgg tgtgcatcca ctggaagggc    18360

cctctggtgc tgcagcaggc ctacctcatc atgatcagtg cgctcatggc cctagtgttc    18420

atcaagtacc tcccagagtg gtccgcgtgg gtcatcctgg gcgccatctc tgtgtatggt    18480

aggtgggcag caaggctggt gggggcagtg ggggcgatgt ccagggccaa atcgtcccca    18540

gtgctgcaca aggagggcag gtgctgaagg gcttgcatcc ctttctgcag aggcctgggt    18600

gggatccctc ctgagagagt cgcctttgta aaacagaggg gggtccacta tttctggaac    18660

actcctggtg gtctagataa aacgcagtag tcactgagct cctcatttac tttttttttt    18720

tttgagatgg agtcttgctc tgtcgcccag gctggagtgt agtggcgcca tcttggctga    18780

ctgcaacctc cgcctcccgg gttcaagtga ttctcctgcc tcagcctcct gagtagatag    18840

gattataggc atgtgccacc acgctgggct aatttttgta tttttagtag agatggggtt    18900

tcaccatgtt ggccaggctg atctcgaact cctgaccttg tgatcggccc gcctcagcct    18960

cccaaagtac tgggattaca ggcatgagcc actacaccca gcctcatttt ccattattac    19020

tgctatgctg attgagcaag tgcactgtta agcactggac acgctgtaag tgatttgttc    19080

atcaagacag tcctttgggt accatgcata tacataaccc caaatgttag ctgctatttg    19140

atattagcat gattatcatt gccagtattg ttacttccat tttaaggtta aagaattgga    19200

ggctcagaga agtgggactc cccagcctgg ccaccgcgtc tcgggtgcac agctcctcca    19260

tgcttgcagt tgcctgcgag gccctactct ggctcacacc agggcctgct ctaagttgtg    19320

actggagaat gagaatttgg gatgccagcc cagaggcaag gcatgctctg agagctccac    19380

ccggggctcc tgtgctacag ggcaggctct tcttcagggg gctgcccggg gatagtttga    19440

caaggatgtc tctgtcttcc tagatctcgt ggctgtgctg tgtcccaaag ggcctctgag    19500

aatgctggta gaaactgccc aggagagaaa tgagcccata ttccctgccc tgatatactc    19560

atgtgagtga gccccccgtg cctctgcctg actcggggtc agcaggcagc ctgtgggggg    19620

acaggggcct gcttcctggc cgtggctttc agagttgact gggcgatccc aggagggtct    19680

ccactttcag aagccaggga gggcagtatc ttgttattac acagtaagaa gcttagaaag    19740

ttaggacagg aagcaggcat ctgctgggat gtgctgcagt ccctgacttc atcccgtcca    19800

tcctccagcg gcatgctgcg gtgcaggttg cattcctgtg atcccgcagc cacccctcag    19860

ctctccaggc tcttgagaag ggactttgga gagggattct tcagggcagg gggtcgggga    19920

gcaaggagct tctgggcttc cttgacagca gcgtggctga ttggcattaa tcctaactga    19980

agggaaggca cacgggatgg cccctggcct cggggtcaat gtgtagagat ttggacttac    20040

acatgcagtc aacaaaggca catcaagtcc ccattttgtg acaggcactg tgctaggcat    20100

tgggggaccc agcaggaaag aagaccacag ggtcccaggc ctcatggagc tcacggccct    20160

gtgattgtga tgccctcggt ctgttgatgg cggggcttaa atagcctgaa tttctggagc    20220

tctggcgtct gcaaggtggc ctgggaaaga gtttatggaa cagctacaga gttctaggta    20280

ccttcatgca gttgaggatt cgagcccgta gaggagaatc gcctgcagcg tggccccacg    20340

ggaaagcaca ttccaggcgc attccgagga tgagcggaga ccatgtatgg aaaggtagtg    20400

ccaggactgt catgagtgtc ccagggctcg ggggattcac ccgtgaactg tgaggtcttg    20460

gctctgatag acctggttct tatgctttag gaggggagac aaacagtaac agaatagaca    20520

aatgcaagag agagtgactc tggacccctc ccacaacggc ctcctaacaa tggagcatga    20580

gcagatacct gcaggatgga gggtcctgtg caggctttct gggacgcaga ctggccacct    20640

cccccaggcc ctgcaggcag ccactgttag caccgcctga gatgtgaacc ttttctcctc    20700

ccccagctgc catggtgtgg acggttggca tggcgaagct ggacccctcc tctcagggtg    20760

ccctccagct cccctacgac ccggagatgg gtgagtatct tggggagcta acagcctctc    20820

atcactgggg ggcagctccc tacctgcacc cagctctgct cggcctggct tccctgagag    20880

gcatgagttc aggaggggca gagggaaagg tccgttgaaa accagccgga cacatgcggc    20940

ttgaagattc agcaagtgtt ggaccctcgg tcctctgcca gcctctgttg catcgttctg    21000

ctgggcgtgg gtgggtggag tgggggaagc cctggtgtca ggtgctggtg ctcaggggga    21060

ccccttcttg gagctttgtt ccctggtaac actctgacca gctgttgttt ctctctcttg    21120

ttgtcccctc ctcacggtga tgacggacat cttctcttcc tggacaccca gaagaagact    21180

cctatgacag ttttggggag ccttcatacc ccgaagtctt tgagcctccc ttgactggct    21240

acccagggga ggagctggag gaagaggagg aaagtaaggt gcccatgttc acacggcctg    21300

cttcagccta cggcgggagc ggagacagag ggtggaggct ccctgcagcc tgggtggagg    21360

agggcatgag gggaggggcc ccttttccca tcagaggcat ctctgtgaaa gtagaagatg    21420

cctgcagcgc tggggtcttc tcagcaggcc ccatgtagtt gtccggcatg tattgagtat    21480

gggccacgtg cccgtgctgt gctgggtgag gcccagccct ggtgggaccc acaggctaag    21540

gagacacggg cagtaatcac atagactgag aagccaagga ctatgaaggg ggccatgggg    21600

ttggggaggg gcggcaggag agcatgccac ggggcttctt gacctggttg gcaggggtga    21660

gagaaagtca gctgaggaag taactgctga gctgagctct gaaggttgag tcacagcagt    21720

cactagagga gaggagcaca gggtggggag catttcctga cagacagact caggaatcag    21780

aggaagccgg ggcgggatgc agagagcaga agtgtgggag agccttgcaa acaggcctgg    21840

agacatgcga agataggagt tcatcctggc gtcagtacac ggtgcctgcc taacacccaa    21900

tgccagccca ctgctgcgtg ccaggcagca ccctggagca gggagatgct gcactgtcgt    21960

aacagcccct gccttgagag gtgccttacg ggagcagcct ggtgacagtg gcttggcata    22020

caggactcca gtgacacggg aggggcaagc tagggaaaga tcactctgcg gtgggtctgg    22080

aaggaggagc aggtgcgcac cctccaggca ggcttggggg aggtatttat tccaaggcca    22140

actggtgtgc tgcagaccag gagttagcac agatcccacg gggcccgcag gactggcctc    22200

cctccagaca ccagccacaa gctctagagg gtctagatgc cacttgtgct tctgaccggc    22260

tgcaaattta gggctcccat gaccccctta ggttcaataa cttgctagaa tgactcacag    22320

aactcaggaa agcactacac ttaaaattgc agtttgtttt ttgttgtcgt tttgttttgg    22380

agacagggtc tcgctctgtt gcccaggctg gagtgcagta gcacgattgt ggctcactgc    22440

aaccttgact tcctgggctc aagtgatcct cccaccttgg cctcctgagt agctgggatt    22500

acaggcacgt gctaccacac ctggctcatt tatattttta gtagagacaa ggttttgact    22560

tgttgcccgg gctggtttcg aactcctggg ctcaagtgat ccacctgcct tggccttcca    22620

aagtactggg attataggtc tgagccacag cacccggcca aaattagttt tattataaga    22680

gatgcaactc aggaccagcc aaatgaagag acagtgaaga agtaatgctg atggatcaca    22740

cctggtgggg gaaggaggac agctggggcc aggagcagga gggacacctg cagggctgga    22800

agggcagggg aggtgggcct ccatggtttg tgtttattgc ataaccattt ttattgtcta    22860

cagtgagcaa agttatccta taaacaagtg tcagggacca ttgcactaaa gaaaacaaac    22920

gagagcattt tggaagctct aatttcctga tcagtaatgg gtagactaat tcccagttat    22980

atttacctgt tgtaaggtga aaggttcttc agaggacctc tgtcttggtg ttatatgggc    23040

ttttgaatgt actgaaatta aattccctaa aaatctgtga ttcagacttc atactaaatt    23100

gtacagcagt gcccagccca aggccttgca tttctatttg ttgttttctt tactctctaa    23160

gtgcccaaca ctggttttac ctgagtttca gaactgcccg cttttctctg cccaggttgt    23220

aagtcaccca gtccacaggt gtcccctgct ttcccactgg ccactgattt ggggaggcag    23280

ctgtccatgt ccccagtcca catcttagct tctagaggcc aggtggggtg ggctgggctg    23340

ggcaagagca gctgggcctt ctgggccaga gtttctcttc tttttccatt ctgtgcacgc    23400

ctcttcagta cgggttactg tctctcctca cacagggggc gtgaagcttg gcctcgggga    23460

cttcatcttc tacagtgtgc tggtgggcaa ggcggctgcc acgggcagcg gggactggaa    23520

taccacgctg gcctgcttcg tggccatcct cattgtgagt ggctggggat gcgtccagct    23580

gcctcgtggt gggggccccc agggtcctca ttgtggtggg ggcaggtctc aggatcccta    23640

gggatttttc atttcttctc ttccctctga gggacaagag cagggagcgg ggctggaagg    23700

gtcagcttga gaccaaggct cacaggaggt gtgctcgccc ctaggtgggc tccagcctgt    23760

ggaggacagt gcaggggagg gtgaggagtg taccggcccc agcgtggctg agcacacagc    23820

ctccaggccg aggacccagc tgacagcttt gcgcagtgat gataccctcg aggtggttgt    23880

gatgacatca gatttgcaga aaagaaaatt gcttaagggc cttgcccatg ggcgcaaagc    23940

tagtgaggac catgttttcc ccctcctcca tgccattggg acaccacagg gtctgaatct    24000

ggggcactag gggtggcccc gttactgtga accacagcag tgaaatgtgg aggccctgta    24060

gtcagttaac gtgaccagat acacataatg gggagacgtc ctgccgtgac ttcatctcag    24120

agatttcgct gtcacgttag aggaggagga gcgtctgagc cgtgcgcttg gcatctgccc    24180

cttagtgaaa accctgggca tggcatgatt aaggttgatg ctccagtgtc cagaaggttt    24240

tctttttgcc cacaagtata tcagggatgg gatggtggac ccaggctcct ccaccaccag    24300

actgccttac ctgagccctg ctggccccaa agatatagaa ggcaccctgg ttccctgtgc    24360

tcacctggac cactgcctgc atcagctggg tcaggggagg atgggcagcc cccacacctg    24420

cttcccaggg gcaggttgcc tggcggctct gattcccttg gtgccagctg ctgagaacct    24480

tactgccatt tcagttgagc ccacctagct ctcatataaa tacatgttcc ctgagggcat    24540

cttaccatcc catgtgacca ctccagccag acaggggagg cagcacggcc tcggggcaca    24600

gcactgctcc aggagtcagg aggcctgcct tctggttcac tcactaacag gtgaggtgat    24660

ctaatggggg tgagaacttc tgcccttaac acctcaagag ctgttgcagg accagggaag    24720

ataatggggt gtctagcgcc gttatccgac tggtcctcga acaagctcct gtgcccaggg    24780

actagaccat gactcacagc tcctgtccac accagggatc accacgctca ccctcccctc    24840

catgtcctgc agggcttgtg tctgaccctc ctgctgcttg ctgtgttcaa gaaggcgctg    24900

cccgccctcc ccatctccat cacgttcggg ctcatctttt acttctccac ggacaacctg    24960

gtgcggccgt tcatggacac cctggcctcc catcagctct acatctgagg gacatggtgt    25020

gccacaggct gcaagctgca gggaattttc attggatgca gttgtatagt tttacactct    25080

agtgccatat atttttaaga cttttctttc cttaaaaaat aaagtacgtg tttacttggt    25140

gaggaggagg cagaaccagc tctttggtgc cagctgtttc atcaccagac tttggctccc    25200

gctttgggga gcgcctcgct tcacggacag gaagcacagc aggtttatcc agatgaactg    25260

agaaggtcag attagggcgg ggagaagagc atccggcatg agggctgaga tgcgcaaaga    25320

gtgtgctcgg gagtggcccc tggcacctgg gtgctctggc tggagaggaa aagccagttc    25380

cctacgagga gtgttcccaa tgctttgtcc atgatgtcct tgttatttta ttgcctttag    25440

aaactgagtc ctgttcttgt tacggcagtc acactgctgg gaagtggctt aatagtaata    25500

tcaataaata gatgagtcct gttagaatct tggagtttgg tccgttgtaa atgttgaccc    25560

ctctccctgc atcttgggca cccctgggat aacttgtgct gtgagcccag gatggaggca    25620

gtttgccctg tttgaaggaa cttttaatga tctcgcctct ctgcacacat ttctttaact    25680

agaaagtttc ctaagcaaag gagttaggag agcagggtgg cctgacatct gccagccctg    25740

agctgtaagg ctgtggatgc tgagcaggtc cctggactca gttgtgcacg gtggcacaga    25800

cactgccagg tggttgccaa aacatccagt ggttccttca gcaagtgttc accctctgca    25860

gaagcctgtg agggcctgag ctcagaaacc actctccttt ccttctctgg ctttggccct    25920

gggcactgtg gtgggagagt ggacagtttg gctttgcctt ctctgtacat caatcatggg    25980

ttgcaaagag aatctcagaa gtgcctcttc ctgagcacag tggctcacac ctgtaatccc    26040

aatacttcgg gaggtcgagt cggaaggatc acttgagccc aggagtttga gaccagccgg    26100

ggcaacatag tgagactttg tacaaaaaaa aatttaaaaa ttagccaagc atggtggcat    26160

gcatctgtag tctcagctac tctggaggct gaggtgggag gatcacttaa gcccaggagg    26220

ctgaggctgc aatgagccga gatcaagcag gtgttaggta tatcagacag ctgagaagac    26280

gcaagtgtgc cctggggttc aaactggtac ccctgtctcc ctgttccagg aataacatga    26340

gtgccgggac aatgcatctt tattatgaga ggaatgagaa ttgtgtatct tgacatttga    26400

caggagcttg ctttccccca ggctgtttga ggaagggcag aggaaaatgt ggtgccctaa    26460

gaaggaagga cagaggaggc cgaacactgg cgggtggaat cccactgatt agtagtgcag    26520

gtcagagacc tgggatgggg ggcattgccg tcatggaagc cacagcgggg agcgggtaaa    26580

gcagacaggg atggtccctg atggtgacaa ctcgcaagag gttaagggga aagaaaaact    26640

gaaaagctta ttcaatttgg caattatggc agtgtttatc ttcagaagag cagttttagg    26700

gtggggtttc caaagatggg attggacata tattttgaat cattaagctt gaggtctttc    26760

aaaggcctgg ccaagggttg ctgggtggag accacattca gaggtaaagg cagaaattgg    26820

gggcccttaa gtagacagcg agggaggaag aaatgaaggg gcctggtgat ggttagggtg    26880

aagtgttaag actgagaaaa caaggacatg tgagaagacg agggaagagc attggagaga    26940

acaaagacac tggaggagat gctacttgga ggtccccaga gagcagggag acaaatgaac    27000

ccagaacaca aatggcaaag aagaaaaatg agagaatttg taaaagacag cattcgaaca    27060

tgccgaacaa gagcagggta ctggtgttca aacacctgta tctcccccgt gtaacccgtc    27120

aactaatatc tttccatatt tgctccagat ttgtctttag aaataaaacc cacgttctga    27180

agtcctgttt gtatgtggcc ccagtcctgt tgcctccgcc tcctgtcctg aagtcgattt    27240

ctgcccttct catctatggt tagttttgtt ttgtatgttg gcatgttttc ttaactttac    27300

agaaatggta tcatactgta catatttgat aattttttaa aatattgcat tctggaggca    27360

tgtataaatg tagctccagt tcatttattt tatttatttt ttgagatgga gttttgctct    27420

tgtcacccag gctagagtgc aatggcgtga tgttggctca ctgcaacctc tgcctcctgg    27480

gttcaagcaa ttctcctgtc tcaatttcct gagtagctgg gattacagtt gcccgccacc    27540

atgcctggct aattttgtat tttagtagag acggggtttc accacgttag ccaggctggt    27600

ctcaaactcc tgactgcagg tgatccacgc accttggcct ccaaaagtgc tgggattaca    27660

ggcgtgagcc accgtgccca gcccagttat tttaactatt gtatagtgtt ccattgtatg    27720

agttctactg tttatatgct attgatcgac ctgtaggggt tttgcagtgt ttctgtatta    27780

cagctgtgct gcagtgagca tcccatcaca ttgtgtggat ttgaggaagt attggaattc    27840

ccccaattga ctggacattc ccaattaccc tccaagtatg tgtctgttta tccttccatc    27900

cgcaatctga gagttcccca actctataat acttggtgtc atcagacttt tcatcttgtc    27960

tgattggatg ggtgtcattt cctttaggtt ttataattat cttttcatat gtgtattggc    28020

tgtacaaggt tccttctctg ttcattatta ttaatttttt tagacagagt ctcgcgctgt    28080

cgcccaggct ggagtgcagc agcgtgatct tggctcactg caagctccgc ctcccgggtt    28140

catgccattc tcctgcctca gcctcctgag tagctgggat tacaggtgcc tgccatcacg    28200

cccggctagt ttttttgtat tttgagtaga gatggggttt caccgtgtta gccaggaggg    28260

tctcgatctc ctgacctcgt gatccacccg cctcggcctc ccaaagtgct gggattacag    28320

gtgtgagtca ctgcgcccag cccaagtttc cttctctgtt acttgttcat atcctctgcc    28380

catttttcac ttggattttt tgtcttacgg atatttaagc ctcttaaaat atatattctg    28440

gagagatgct aatctttgat taattatatg cattgcaaat gtctggtaca ttgtggcttg    28500

cctctcttcc ctgcctttag gagtgttttg ctggacccaa gtaattttta aatgttaatg    28560

ttattaaatc tatcagtttt ttgcttgtat ggcttatgcc attgaatctt gttttaagag    28620

atccttccct accctcaagg ttttctaaat ttttattttc ataataagat ttttagttca    28680

tctgaaatgt atttttatga ttgtatttag tagggaccta attttgtttt tctttgtaac    28740

caggtgtccc agcactgttt actgaacagt ctctcctttc tcgctggtct gtagaactct    28800

cctgacatat accaagtttc cataagtggg tggatgggtt cctgagctct ctactgttaa    28860

tagaacttgc tctctcgcag gccaatgcct caccaggtga ttgaagcaga gaaacttagg    28920

tggtgaaagg agaagatggg gcctgtcctg agagtttctg ttcctgagat gctagaggca    28980

gagggtatgt aaatctgaag ttacactgga tctcctaaaa cagtataaag ctacagaagt    29040

ataatagtgt ggaatggtgg tgggagtcag taagggttag gtcactgcag tggtttaaac    29100

aagatgggct agaatccttt cacaggcaca ggcagcttgg agagggtgca atagtgcatg    29160

gtatcagggg tcagatgcct ctttttcctt tgagatcagt aagtggcttt cacctcatga    29220

cctaggctgg ctgctgtgtg ctagccgtca agtcacactc catccagcat gaaaggaggt    29280

tagaaaaggg tgcatttcct cttcttaaaa acatgtctca aagttgcaca cagcactttt    29340

gcctatattc aattggccat tagtcccacg gccatacctg tctgagactg agagactggg    29400

aaatgtcttt atttcaagtg gccatatatc cacctaaaca agataaggga tacgtggtta    29460

tggcgtgtct tttggtttac caatgcagat aatgaagtta ccaaaacaat gagaaaatgg    29520

ggtcgtgagg gatcatgtga atcacaagct gatgtcttca aagacggtgg aaatgggccc    29580

cgggaggcag cagatgacag cagtggggat taaggtagac ctccatcctg gggttaaaat    29640

gaggggaagg tgatggagct ggaccagcag tcagaatggt cagtggttag gagaccctct    29700

gccccccacc gctgccacca ttggctctct acagaatgcc tgcgagtggc ttagagtgac    29760

caaggatgag gtgcagatcc atgtgcaccc ccctgccccc tctgtggaca attttcatgc    29820

ctgacagcac agtctatgtg gattgcaagc cgatgaaact atgcaaagta gaagcatgcc    29880

tgcagtttgt gattcggtga tgtgttttat gcttatgtga gtcgaatggg gcggcagggt    29940

cctgtggtca cccgctgaga aggaagggtc ctgtaaccac tgcctttctt tcagctactt    30000

gagaaaggtg ttgtgaggga ccgtggattt tgggacagct ttgaatggtg gtagggagga    30060

agggtccggt ctgagtgaat ggccagaaag ctgtggggaa gcttttagga cattggccaa    30120

gagctccctg aaggcagcca gggagatact tgtcagtaca tgtgactaat ggccaactga    30180

atataagcag aagtgctgtg ttgctgtgtg caacactgga caccttagga aggacctcga    30240

gacagtggtt gtggactctg tagagagtaa cagtgacagt agcaaaccct tacccagtgc    30300

caaccttgtg ctaggctcgc actaaatgag tttaccttca attctcgtaa caataggagg    30360

taactactat tctaatttcc attttataga tgaggaaact aaggcacaga gatcactgac    30420

ttgcccaaaa tcaagcaggg agtagttagt atataagccc acggtatgtg gtttgtagaa    30480

taggtgctct tgactagcag aaataggtcc tccctgcagt gtgtaattga taacaagcat    30540

gggctgccat cttcctgtcg aggccactca aaacacccaa caggctacgc acggtggctc    30600

acacctgtaa tcccagcact gtgggaggcc gaggtgggcg ggtcacctga ggtcaggagt    30660

tcgagaccag cctggccgac atggtgaaac tccgtctcta ctaacagtac aaaaattagc    30720

tgggcgtggt ggcgggcacc tgtaatccca gctactcagg aggctgagac agaagaatca    30780

cttgaaccag ggaggcagag gttgcagtga gacaagatca cgccattgca ctccagcctg    30840

tgtgacaaaa gcgaaactgt ctcaaaaaaa aaaaaaaaaa aagtatgatt ttataatccc    30900

agcaccttgg gaggctgagt cgtgagaatc acttgagccc aggagtttaa gaccaatcta    30960

ggcaacatgg caagacccca tctctgccaa aaataaaaaa tagtctaatt ttagctattc    31020

atgtgtgtgt gaagtggtgt ctcttcgtgg ctttgatctg catttcccta atgctgacta    31080

atgacgttgg gcacctgttc atgtgcttac tggtcagata tctttctttt gttacatttt    31140

attaagtttt aaaatttaaa gtcaaagatt tccctatgag aatgactttt aaaatgacca    31200

aaaaggggaa gataacatta attcttgaag agaaggcctc tgagaaaaat acagttgtag    31260

caagctgcta ctttgcaaat gacccatgca ttttaatttt cccctaagga aggccaagga    31320

agagtcttat cacctcaggg caggagatgt agggacttgg gtcatttaat aagagtggta    31380

ggtttgaaaa ctcaaaccca gaagactcct tagagtttct cccaggaggt agggaagggg    31440

ccgcatccat ggagagagga ggatgtgact tagagcagtg gtccccaatc tttagggacc    31500

agggactggt gtcatggtag acagtttttc cacagatagg ggttgggggg atgatttgga    31560

gctgaaactg ctccacctca ggtcatcagg cattagattc tcatgtggag tgtgccactt    31620

agatccttgg cgtgcacagt tcacaatggg gttcgaggtc ctatgagaat ccgatgccac    31680

tgatttgaca ggaggcggag ctcaggtggt aatgctcatc tccaccgctt accacctgct    31740

gtgcagcctg gttcctaata ggctatagac tggtactggt ccatggcctg ggggttgggg    31800

acccctgatt tagaggaagt aagggcatgg cttaccgtgg gccctggggt gttctgggaa    31860

tggggaggat ggagagaaga gaggaggtag ggaagacctc cccttgctcc ccatttggga    31920

tttggggaga aagtcaggtc tcaggctcaa cagtacctga tcctgtacca tcttccaaag    31980

ggaagtcagt ggggttggaa ggtaggcagg ggttatcttc tctgagccac ggcacaagac    32040

agaagtttcc caccattcct gagggggcag gtggtaggtc cccaagcaga gagccagcag    32100

tccctctctg aggcctgcaa tggaatgggg tggggtgtcc actgagccaa gggtctgtca    32160

gtgagagctg gggaggctgg gctggcttgc aagcacctgt tataaccaaa ccaggaaatc    32220

aggttccgag tcttgccagc aagggcctac agctgccagc agagatggac agccaggaga    32280

ccccaattgg ccacccagag ccaccctcct ctgcctaccc caccctccag tactccagag    32340

cctactcgga ggggaacaga aacctgagag gctgaacaca cacacatgga gaaacaaacg    32400

tagtaaaata tttggggaat caggaagaat tatttgtact attcctgcaa cctttctata    32460

ggcttgaaat tatcaaaata aatttttaaa aattgtaata acattctcat actaaaacac    32520

tgagtttttt tctttcattt tttgattttt tctttttgac tccagcatga cttactctaa    32580

caatgggtgg tctcgatttt gaaatacttt cttctccaag cctttcatga caccctgtct    32640

ctgttggttc tgaaaatgtt ggattttgtc tcagcccttg cttctggaaa cagccaaggt    32700

taagaaaacc ccccatgctt tgtgttctag cagacagctt cctgcaaaga gccatcttcc    32760

cagagcactt aggcctctta gatgtctccc ttgtttaatt atgacaagag cacacacaca    32820

gaccctccaa attcccattc ttagtcttct aaatgattag ctgagctgct tttccccact    32880

gattaatcgg aataaaatgc tcattaacca aacttccctc ctttccccag gtccctaaac    32940

tttcctgagt cggcagacat cccctctgga gaagaggttg gccccagagt cgaacatcct    33000

ctgatctacc tgatcctgct gcccttccat tccacttccc cacatctgtt ctttctggtc    33060

gtgtttactc ccctattaaa aaaacaaaac cagaaaacgt gtttgcctag atcttgagac    33120

tctggaagat cttaacagtc agaggttccc cctatttgca atgatctcct ttcctgcccc    33180

ttcctatcct tgcaataatc cttttgaata aagtctctcc ttactaaatc cagttcctaa    33240

aaattaattt ttttagag                                                  33258


<210>  2
<211>  448
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  presenilin-2 isoform 1

<400>  2

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  3
<211>  19
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5'-3' Primer

<400>  3
catcagccct ttgccttct                                                    19


<210>  4
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 3'-5' Primer

<400>  4
ctcaccttgt agcagcggta                                                   20


<210>  5
<211>  26
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5'-3' Primer

<400>  5
acagaattcg ccccggcctg gtacac                                            26


<210>  6
<211>  25
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 3'-5' Primer

<400>  6
taagcttggc acggctgtcc aagga                                             25


<210>  7
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5'-3' Primer

<400>  7
tcagcatcta cacgccattc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 3'-5' Primer

<400>  8
agcaccacca agaagatggt                                                   20


<210>  9
<211>  26
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forwad 5'-3' Primer

<400>  9
attcgccccg gcctggtaca ctgcca                                            26


<210>  10
<211>  27
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 3'-5' Primer

<400>  10
ctgtccaagg agctgcaggc ggcgcag                                           27


<210>  11
<211>  25
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  g1N141I guide RNA F

<400>  11
caccgcatca tgatcagcgt catcg                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  g1N141I guide RNA R

<400>  12
aaaccgatga cgctgatcat gatgc                                             25


<210>  13
<211>  100
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Donor ssODN#A N141I

<400>  13
gagagaagcg tggctggagg gcagggccag ggcctcacct tgtagcagcg gtacttgtag       60

agcaccacca agaagatggt cagggtgttc agcacggagt                            100


<210>  14
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5' Primer

<400>  14
taacggcggc agacaaaaag a                                                 21


<210>  15
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 5'-3' Primer

<400>  15
gaagtattgc ttcagttggc ct                                                22


<210>  16
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5' Primer

<400>  16
agaagaacgg caagtacgag a                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 5'-3' Primer

<400>  17
tgttgaggga cagattgtgg c                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5' Primer

<400>  18
taacggcggc agacaaaaag a                                                 21


<210>  19
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 5'-3' Primer

<400>  19
gaagtattgc ttcagttggc ct                                                22


<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5' Primer

<400>  22
acgaatctcc gaccaccact                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 5'-3' Primer

<400>  23
ccatggccac aacaactgac                                                   20


<210>  24
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5' Primer

<400>  24
gaagtgtccc aggacatgat aa                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 5'-3' Primer

<400>  25
ctcttgagta gctgggattg ag                                                22


<210>  26
<211>  46
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5'-3' Primer

<400>  26
ctccgtgctg atcaccctca tcatgatcag cgtcatcggt tatgac                      46


<210>  27
<211>  48
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Reverse 3'-5' Primer

<400>  27
gaggcacgac tagtgggagt agtactagtc gcagtagcac caatactg                    48


<210>  28
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Forward 5'-3' Primer

<400>  28
catcatgatc agcgtcatcg                                                   20


<210>  29
<211>  25
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  g1N2411 guide RNA F

<400>  29
caccgcatca tgatcagcgt catcg                                             25


<210>  30
<211>  25
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  g1N2411 guide RNA R

<400>  30
aaaccgatga cgctgatcat gatgc                                             25


<210>  31
<211>  118
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Donor ssODN#A N141I

<400>  31
gagagaagcg tggctggagg gcagggccag ggcctcacct tgtagcagcg gtacttgtag       60

agcaccacca agaagatggt cataaccacg atgacgctga tcatgatgag ggtgttca        118


