                         SEQUENCE LISTING

<110>  AMGEN INC.
 
<120>  ANTI-JAGGED1 ANTIGEN BINDING PROTEINS

<130>  A-2156-WO-PCT

<140>  PCT/US 18/XXXXXX
<141>  2018-05-30

<150>  62/512,805
<151>  2017-05-31

<160>  358   

<170>  PatentIn version 3.5

<210>  1
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  1
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc gactggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctttgct gcatccagtt tgcaaagtgg ggtcccatcc      180

aggttcagcg gcagtgaatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccgatcac cttcggccaa      300

gggacacgac tggagattca a                                                321


<210>  2
<211>  357
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  2
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa tgaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacatgac      300

cacagtcact acggttttga ctactggggc cagggaaccc tggtcaccgt atcctca         357


<210>  3
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Gln 
            100                 105         


<210>  4
<211>  119
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp His Ser His Tyr Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  330
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  5
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgccgttggt ggtcataact ttgtctcctg gtaccaacag      120

tacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctactcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcttata caagcagcag cacttgggtg      300

ttcggcggag ggaccaggct gaccgtccta                                       330


<210>  6
<211>  360
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  6
caggtcacct tgaaggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcagc aatgctgaaa tgggtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacaccttt tttcgaatga cgaaaaatcc      180

tacagcacat ctctgaagag caggctcacc atctccaagg acacctccaa aagccaggtg      240

gtccttacca tgaccgacct ggaccctgtg gacacagcca cctattactg tgcacggtcg      300

tttaactgga actacgactt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  7
<211>  110
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  7

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Ala Val Gly Gly His 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Thr Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110 


<210>  8
<211>  120
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  8

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Ala 
            20                  25                  30          


Glu Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Leu Phe Ser Asn Asp Glu Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asp Leu Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Phe Asn Trp Asn Tyr Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  318
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  9
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagg agcaacttag cctggtacca gcagaaagct      120

ggccaggctc ccaggctcct catcgatggt gcatccacca gggccactgg cataacagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctacttt cggccctggg      300

accaaagtgg atatcaaa                                                    318


<210>  10
<211>  354
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  10
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatggtgg gaacacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccatag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgggagaa      300

ctgcggaggg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ttca            354


<210>  11
<211>  106
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  11

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Asp Gly Ala Ser Thr Arg Ala Thr Gly Ile Thr Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  12
<211>  118
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  12

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Gly Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Glu Leu Arg Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  13
<211>  333
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  13
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60

tcctgcaccc gcagcagtga cagcattgcc agcaactatg tgcagtggta ccagcagcgc      120

ccgggcagtt cccccaccac tgtgatcttt gaggataacc aaagaccctc tggggtccct      180

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240

ctgaagcctg aggacgaggc tgactactac tgtcagtctt atgatagcag caatcatgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  14
<211>  363
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  14
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt tactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcat      300

gactacggtg tcctgtacta ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  15
<211>  111
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  15

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Asp Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Phe Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  16
<211>  121
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  16

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Asp Tyr Gly Val Leu Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  318
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  17
tcctttgaac tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg gagatgcatt gccaaagcaa tatgcttatt ggtaccggca gaagccaggc      120

caggcccctg tactggtaat atataaagac agtgagaggc cctcagggat ccatgagcga      180

ttctctggct ccacctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcaaca gacagaagag gtactgtgtt cggcggaggg      300

accaagttga ccgtccta                                                    318


<210>  18
<211>  369
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  18
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attggaatga tgataagcgc      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacaga      300

catggctacg ataggatgcg tgatgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210>  19
<211>  106
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  19

Ser Phe Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile His Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Asp Arg Arg Gly Thr Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  20
<211>  123
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  20

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg His Gly Tyr Asp Arg Met Arg Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  21
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  21
gaaattgtgt tgacgcagtc tccagacacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gatttttagc agcagttact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctct ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggtca gacttcactc tcaccatcag cagactggag      240

cctgaggatt ttgcagtgta ttactgtcag cagtatggta gctcatgcag ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  22
<211>  381
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  22
caggtgcagt tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctacttta tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag tacagtctac      240

atggagctta gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatcag      300

gagggagcag tggctggtac agactactac ttctacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210>  23
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Phe Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ser Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Cys 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  24
<211>  127
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Glu Gly Ala Val Ala Gly Thr Asp Tyr Tyr Phe Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  25
<211>  336
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  25
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctccta catagtcatg gatacagcta tttgaattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatcc atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagaatttac actgagaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagttct gctaactccg      300

atcaccctcg gccaagggac acgactggag attaaa                                336


<210>  26
<211>  360
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  26
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaaataa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagac cacgctgtat      240

ctgcaaatga acagcctgag acctgaggac acggctgtgt tttactgtgc gagagatgcc      300

agtgggagct ccctctacct tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  27
<211>  112
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  27

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


His Gly Tyr Ser Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile His Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Val 
                85                  90                  95      


Leu Leu Thr Pro Ile Thr Leu Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  28
<211>  120
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Gly Ser Ser Leu Tyr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  336
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  29
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtcatg gatacaacta tttgaattgg      120

tacctgcaga agccagggca gtctccacac ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagaatttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagttct acaaactccg      300

atcaccctcg gccaagggac acgactggag attaaa                                336


<210>  30
<211>  360
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  30
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa aaaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatgcc      300

agtgggagct ccctctactc tgactactgg ggccagggaa tcctggtcac cgtctcctca      360


<210>  31
<211>  112
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  31

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


His Gly Tyr Asn Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Val 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Leu Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  32
<211>  120
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Gly Ser Ser Leu Tyr Ser Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ile Leu Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  336
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  33
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gggcctcctg catagtcatg gataccacta tttgaattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagaatttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagttct acaaactccg      300

atcaccctcg gccaagggac acgactggag attaaa                                336


<210>  34
<211>  360
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  34
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacagtt atatcaaaag atggaagtta taaatactat      180

gcggactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagggatgcc      300

agtgggagct ccctctactt agactactgg ggccagggta ccctggtcac cgtctcctca      360


<210>  35
<211>  112
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  35

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Leu His Ser 
            20                  25                  30          


His Gly Tyr His Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Val 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Leu Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  36
<211>  120
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  36

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Ser Lys Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Gly Ser Ser Leu Tyr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  330
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  37
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agaaatactg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagtctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag ggaccaagtt gaccgtccta                                       330


<210>  38
<211>  360
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  38
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaataccat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagga cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gggggacttt      300

gcttacttct actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  39
<211>  110
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  39

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Val Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  40
<211>  120
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Phe Ala Tyr Phe Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  41
<211>  318
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  41
tcctatgagc tgacccagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg gagatgcttt gccaaggcaa tatacttatt ggtaccagca gaaaccaggc      120

caggcccctg ttctggtgat atttaaagac actgcgaggc cctcagggat ccctgagcga      180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcaaca gacagaagtg gtactgtgtt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  42
<211>  369
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  42
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attggaatga tgataagcgc      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacaga      300

catggctacg ataggatgcg tgatgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210>  43
<211>  106
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  43

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Arg Gln Tyr Thr 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Phe 
        35                  40                  45              


Lys Asp Thr Ala Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Asp Arg Ser Gly Thr Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  44
<211>  123
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  44

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg His Gly Tyr Asp Arg Met Arg Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  336
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  45
gaaattgtga tgacccagac tccattctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtca gagcctcctg catagtagtg gaaagaccta tttgtattgg      120

tacctgcaga agccaggcca gcctccacag ctcctgatct atgaagtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tatttctgca tgcaaagtat acagcttccg      300

tggacgttcg gccaagggac caaggtggaa atcaaa                                336


<210>  46
<211>  363
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  46
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcccagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcaac agtggtggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct cttacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaggc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagag      300

agccctacgg tgactacggc ttttgatatc tggggccaag ggacaaaggt caccgtctct      360

tca                                                                    363


<210>  47
<211>  112
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  47

Glu Ile Val Met Thr Gln Thr Pro Phe Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  48
<211>  121
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Pro Thr Val Thr Thr Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Lys Val Thr Val Ser Ser 
        115                 120     


<210>  49
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  49
gacatccagt tgacccagtc tccatcctcc ctgtgtgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggtgagtca ggacattaac agttatttaa attggtgtcg gcagaaacca      120

gggaaagttc ctcagttcct gatctatagt gcatccaatt tgcaatctgg agtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ctttcagcgg cctgcagact      240

gaatatgttg cacgttatta cggtcaacgg acttacaatg cccttccgac gttcggccta      300

gggaccaggg cggaaatcaa a                                                321


<210>  50
<211>  378
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  50
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cctcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt acgactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggaacattt attacagtgg gaggacctac      180

tacaacccgt ccctcaagag tcgaattacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgaggtctgt gactgccgcg gacacggccg tgtattactg tgcgagagat      300

cgcccttatg gaggtaattc cggctactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcccca                                                    378


<210>  51
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  51

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Cys Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Val Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asn Trp Cys Arg Gln Lys Pro Gly Lys Val Pro Gln Phe Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Phe Ser Gly Leu Gln Thr 
65                  70                  75                  80  


Glu Tyr Val Ala Arg Tyr Tyr Gly Gln Arg Thr Tyr Asn Ala Leu Pro 
                85                  90                  95      


Thr Phe Gly Leu Gly Thr Arg Ala Glu Ile Lys 
            100                 105         


<210>  52
<211>  126
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Asp Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Arg Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Pro Tyr Gly Gly Asn Ser Gly Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Pro 
        115                 120                 125     


<210>  53
<211>  327
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  53
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactattagc agcagctact tagcctggta ccagcagaga      120

cctggccagg ctcccaggct ccttatgtat ggtgcatcca acagggtcat tggcatccca      180

gtcaggttca gtggcggtgg gtgtgggaca gacttcactt tcaccatcag cagactggat      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta actcacccat gtgcagtttt      300

ggccagggga ccaaggtgga gatcaaa                                          327


<210>  54
<211>  378
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  54
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cctcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt acgactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggaacattt attacagtgg gaggacctac      180

tacaacccgt ccctcaagag tcgaattacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgaggtctgt gactgccgcg gacacggccg tgtattactg tgcgagagat      300

cgcccttatg gaggtaattc cggctactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcccca                                                    378


<210>  55
<211>  109
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  55

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Met Tyr Gly Ala Ser Asn Arg Val Ile Gly Ile Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Gly Gly Cys Gly Thr Asp Phe Thr Phe Thr Ile Ser Arg Leu Asp 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asn Ser Pro 
                85                  90                  95      


Met Cys Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  56
<211>  126
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  56

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Asp Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Arg Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Pro Tyr Gly Gly Asn Ser Gly Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Pro 
        115                 120                 125     


<210>  57
<211>  318
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  57
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga gagagccacc       60

ctctcctgca gggccagtca gagtgttagg agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catcgatggt gcatccacca gggccactgg catcacagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctacttt cggccctggg      300

accaaagtgg atatcaaa                                                    318


<210>  58
<211>  354
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  58
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actattgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatggtgg gaacacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgggagaa      300

ctgcggaggg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ttca            354


<210>  59
<211>  106
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  59

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Asp Gly Ala Ser Thr Arg Ala Thr Gly Ile Thr Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  60
<211>  118
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  60

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Gly Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Glu Leu Arg Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  61
<211>  318
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  61
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagg agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catcgatggt gcatccacca gggccactgg catcacagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataatt ggcctacttt cggccctggg      300

accaaagtgg atatcaaa                                                    318


<210>  62
<211>  354
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  62
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatggtgg gaacacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgggagaa      300

ctgcggaggg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ttca            354


<210>  63
<211>  106
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  63

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Asp Gly Ala Ser Thr Arg Ala Thr Gly Ile Thr Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  64
<211>  118
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  64

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Gly Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Glu Leu Arg Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  65
<211>  321
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  65
gacatccaga tgacccagtc tccgtcctcc ctgtgtgcat ctgtaggaga cagagtcacc       60

atctcttgcc gggcaagtca ggacattaga aatgatttag gctggtatca gcagaaacca      120

gggaaagccc ctaagcgcct gatttatgtt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatt tgggacagaa ttcactctca caatcagcag cctgcagcgt      240

gaagattttg caacttatta ctgtctacag cataatattt acccgtgcag ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  66
<211>  363
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  66
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctttggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatt ttatcatttg atggaaataa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagagggg      300

gggtataact ggaactacga ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  67
<211>  107
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Cys Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Arg 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ile Tyr Pro Cys 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  68
<211>  121
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Leu Ser Phe Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Tyr Asn Trp Asn Tyr Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  69
<211>  324
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  69
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgtcaag gagacagcct cagaacctat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacatccggc cctcagggat cccagaccga      180

ttctctgcct ccaggtcagg aaatacagct gccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgg gacagcagtg gtgaccatgt gatattcggc      300

ggagggacca aggtgaccgt ccta                                             324


<210>  70
<211>  360
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  70
caggtgcaac tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccgtcagc agtggtggtg actactggag ctggatccgg      120

cagcccccag ggaagggact ggagtggatt ggttatatct attacactgg gagcaccaac      180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgttcaa gcaccagttc      240

tccgtgaatc tgacctctgt gaccgctgcg gacacggccg tgtattattg tgcgagatcg      300

ggtgtagcaa tggctcgctt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  71
<211>  108
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  71

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Ile Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser 
    50                  55                  60                  


Arg Ser Gly Asn Thr Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asp His 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  72
<211>  120
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  72

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Gly Asp Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Phe Lys His Gln Phe 
65                  70                  75                  80  


Ser Val Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Gly Val Ala Met Ala Arg Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  73
<211>  330
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  73
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60

tcctgcaccc gcagcagtgg cagcattgtc agcaactatg tgcagtggta ccaacagcgc      120

ccgggcagtt cccccaccat tgtgatctat gaggataatc aaagaccctc tggggtccct      180

gatcggttct ctggctccat cgacagctcc tcgaactctg cctccctcac catctctgga      240

ctgaagactg aggacgaggc tgactactat tgtcagtctt atgatagcag caatcaggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  74
<211>  363
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  74
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

atctgcactg tctctggtgg ctccatcagc agtggtggct accactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tatattactg tgcgagagag      300

actacggtgg taaaggggta cttcgatctc tggggccgtg gcaccctggt cactgtctcc      360

tca                                                                    363


<210>  75
<211>  110
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  75

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Val Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Ile Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  76
<211>  121
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  76

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Ile Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr His Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Thr Thr Val Val Lys Gly Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  77
<211>  330
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  77
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tattctggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatcttt aggaataatc agcggccctc aggggtccct      180

gaccgattct ttggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  78
<211>  360
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  78
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc       60

tcctgtgcag cctctggatt cactttcagt tacgcctgga tgggctgggt ccgccaggct      120

ccagggaagg ggctggagtg gattggccgt attaaaagca aaactgatgg tgggacaaca      180

gactacgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacacg      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtaccaca      300

gatggggcac tggcccccca cggctactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  79
<211>  110
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  79

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Phe Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Phe 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  80
<211>  120
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ala 
            20                  25                  30          


Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Gly Ala Leu Ala Pro His Gly Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  81
<211>  318
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  81
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga tagagccacc       60

ctctcctgca gggccagtca gagtgttaga agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcaa tacactgact ggcccacttt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


<210>  82
<211>  357
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  82
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtggtt acttctggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagatgg      300

ggagcagcag ccggctttga ctattggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  83
<211>  106
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  83

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Thr Asp Trp Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  84
<211>  119
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  84

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Phe Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Ala Ala Ala Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  85
<211>  336
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  85
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctccta catagtcatg gatacagcta tttgaattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatcc atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagaatttac actgagaatc      240

agcagagtgg aggctgagga tgttggggtt tattattgca tgcaagttct gctaactccg      300

atcaccctcg gccaagggac acgactggag attaaa                                336


<210>  86
<211>  360
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  86
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaaataa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatgcc      300

agtgggagct ccctctacct tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  87
<211>  112
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  87

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


His Gly Tyr Ser Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile His Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Val 
                85                  90                  95      


Leu Leu Thr Pro Ile Thr Leu Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  88
<211>  120
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  88

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Gly Ser Ser Leu Tyr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  89
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  89
cgggcgagtc agggtattag cgactggtta gcc                                    33


<210>  90
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  90
gctgcatcca gtttgcaaag t                                                 21


<210>  91
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  91
caacaggcta acagtttccc gatcacc                                           27


<210>  92
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  92

Arg Ala Ser Gln Gly Ile Ser Asp Trp Leu Ala 
1               5                   10      


<210>  93
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  93

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  94
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  94

Gln Gln Ala Asn Ser Phe Pro Ile Thr 
1               5                   


<210>  95
<211>  42
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  95
actggaacca gcagtgccgt tggtggtcat aactttgtct cc                          42


<210>  96
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  96
gaggtcagta atcggccctc a                                                 21


<210>  97
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  97
agctcttata caagcagcag cacttgggtg                                        30


<210>  98
<211>  14
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  98

Thr Gly Thr Ser Ser Ala Val Gly Gly His Asn Phe Val Ser 
1               5                   10                  


<210>  99
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  99

Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  100
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  100

Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 
1               5                   10  


<210>  101
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  101
agggccagtc agagtgttag gagcaactta gcc                                    33


<210>  102
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  102
ggtgcatcca ccagggccac t                                                 21


<210>  103
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  103
cagcagtata ataactggcc tact                                              24


<210>  104
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  104

Arg Ala Ser Gln Ser Val Arg Ser Asn Leu Ala 
1               5                   10      


<210>  105
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  105

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  106
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  106

Gln Gln Tyr Asn Asn Trp Pro Thr 
1               5               


<210>  107
<211>  39
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  107
acccgcagca gtgacagcat tgccagcaac tatgtgcag                              39


<210>  108
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  108
gaggataacc aaagaccctc t                                                 21


<210>  109
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  109
cagtcttatg atagcagcaa tcatgtggta                                        30


<210>  110
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  110

Thr Arg Ser Ser Asp Ser Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210>  111
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  111

Glu Asp Asn Gln Arg Pro Ser 
1               5           


<210>  112
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  112

Gln Ser Tyr Asp Ser Ser Asn His Val Val 
1               5                   10  


<210>  113
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  113
tctggagatg cattgccaaa gcaatatgct tat                                    33


<210>  114
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  114
aaagacagtg agaggccctc a                                                 21


<210>  115
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  115
caatcaacag acagaagagg tactgtg                                           27


<210>  116
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  116

Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Tyr 
1               5                   10      


<210>  117
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  117

Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210>  118
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  118

Gln Ser Thr Asp Arg Arg Gly Thr Val 
1               5                   


<210>  119
<211>  36
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  119
agggccagtc agatttttag cagcagttac ttagcc                                 36


<210>  120
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  120
ggtgcatcca gcagggccac t                                                 21


<210>  121
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  121
cagcagtatg gtagctcatg cagt                                              24


<210>  122
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  122

Arg Ala Ser Gln Ile Phe Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  123
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  123

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  124
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  124

Gln Gln Tyr Gly Ser Ser Cys Ser 
1               5               


<210>  125
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  125
aggtctagtc agagcctcct acatagtcat ggatacagct atttgaat                    48


<210>  126
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  126
ttgggttcta atcgggcctc c                                                 21


<210>  127
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  127
atgcaagttc tgctaactcc gatcacc                                           27


<210>  128
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  128

Arg Ser Ser Gln Ser Leu Leu His Ser His Gly Tyr Ser Tyr Leu Asn 
1               5                   10                  15      


<210>  129
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  129

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  130
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  130

Met Gln Val Leu Leu Thr Pro Ile Thr 
1               5                   


<210>  131
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  131
aggtctagtc agagcctcct gcatagtcat ggatacaact atttgaat                    48


<210>  132
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  132
ttgggttcta atcgggcctc c                                                 21


<210>  133
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  133
atgcaagttc tacaaactcc gatcacc                                           27


<210>  134
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  134

Arg Ser Ser Gln Ser Leu Leu His Ser His Gly Tyr Asn Tyr Leu Asn 
1               5                   10                  15      


<210>  135
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  135

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  136
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  136

Met Gln Val Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  137
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  137
aggtctagtc agggcctcct gcatagtcat ggataccact atttgaat                    48


<210>  138
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  138
ttgggttcta atcgggcctc c                                                 21


<210>  139
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  139
atgcaagttc tacaaactcc gatcacc                                           27


<210>  140
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  140

Arg Ser Ser Gln Gly Leu Leu His Ser His Gly Tyr His Tyr Leu Asn 
1               5                   10                  15      


<210>  141
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  141

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  142
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  142

Met Gln Val Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  143
<211>  39
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  143
tctggaagca gctccaacat cggaagaaat actgtaaac                              39


<210>  144
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  144
agtaataatc agcggccctc a                                                 21


<210>  145
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  145
gcagcatggg atgacagcct gaatggtgtg gta                                    33


<210>  146
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  146

Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Thr Val Asn 
1               5                   10              


<210>  147
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  147

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  148
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  148

Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  149
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  149
tctggagatg ctttgccaag gcaatatact tat                                    33


<210>  150
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  150
aaagacactg cgaggccctc a                                                 21


<210>  151
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  151
caatcaacag acagaagtgg tactgtg                                           27


<210>  152
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  152

Ser Gly Asp Ala Leu Pro Arg Gln Tyr Thr Tyr 
1               5                   10      


<210>  153
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  153

Lys Asp Thr Ala Arg Pro Ser 
1               5           


<210>  154
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  154

Gln Ser Thr Asp Arg Ser Gly Thr Val 
1               5                   


<210>  155
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  155
aagtctagtc agagcctcct gcatagtagt ggaaagacct atttgtat                    48


<210>  156
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  156
gaagtttcca accggttctc t                                                 21


<210>  157
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  157
atgcaaagta tacagcttcc gtggacg                                           27


<210>  158
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  158

Lys Ser Ser Gln Ser Leu Leu His Ser Ser Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  159
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  159

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  160
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  160

Met Gln Ser Ile Gln Leu Pro Trp Thr 
1               5                   


<210>  161
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  161
cgggtgagtc aggacattaa cagttattta aat                                    33


<210>  162
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  162
agtgcatcca atttgcaatc t                                                 21


<210>  163
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  163
caacggactt acaatgccct tccgacg                                           27


<210>  164
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  164

Arg Val Ser Gln Asp Ile Asn Ser Tyr Leu Asn 
1               5                   10      


<210>  165
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  165

Ser Ala Ser Asn Leu Gln Ser 
1               5           


<210>  166
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  166

Gln Arg Thr Tyr Asn Ala Leu Pro Thr 
1               5                   


<210>  167
<211>  36
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  167
agggccagtc agactattag cagcagctac ttagcc                                 36


<210>  168
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  168
ggtgcatcca acagggtcat t                                                 21


<210>  169
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  169
cagcagtatg gtaactcacc catgtgcagt                                        30


<210>  170
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  170

Arg Ala Ser Gln Thr Ile Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  171
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  171

Gly Ala Ser Asn Arg Val Ile 
1               5           


<210>  172
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  172

Gln Gln Tyr Gly Asn Ser Pro Met Cys Ser 
1               5                   10  


<210>  173
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  173
agggccagtc agagtgttag gagcaactta gcc                                    33


<210>  174
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  174
ggtgcatcca ccagggccac t                                                 21


<210>  175
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  175
cagcagtata ataactggcc tact                                              24


<210>  176
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  176

Arg Ala Ser Gln Ser Val Arg Ser Asn Leu Ala 
1               5                   10      


<210>  177
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  177

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  178
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  178

Gln Gln Tyr Asn Asn Trp Pro Thr 
1               5               


<210>  179
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  179
agggccagtc agagtgttag gagcaactta gcc                                    33


<210>  180
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  180
ggtgcatcca ccagggccac t                                                 21


<210>  181
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  181
cagcagtata ataattggcc tact                                              24


<210>  182
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  182

Arg Ala Ser Gln Ser Val Arg Ser Asn Leu Ala 
1               5                   10      


<210>  183
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  183

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  184
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  184

Gln Gln Tyr Asn Asn Trp Pro Thr 
1               5               


<210>  185
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  185
cgggcaagtc aggacattag aaatgattta ggc                                    33


<210>  186
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  186
gttgcatcca gtttgcaaag t                                                 21


<210>  187
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  187
ctacagcata atatttaccc gtgcagt                                           27


<210>  188
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  188

Arg Ala Ser Gln Asp Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  189
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  189

Val Ala Ser Ser Leu Gln Ser 
1               5           


<210>  190
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  190

Leu Gln His Asn Ile Tyr Pro Cys Ser 
1               5                   


<210>  191
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  191
caaggagaca gcctcagaac ctattatgca agc                                    33


<210>  192
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  192
ggtaaaaaca tccggccctc a                                                 21


<210>  193
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  193
aactcccggg acagcagtgg tgaccatgtg ata                                    33


<210>  194
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  194

Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala Ser 
1               5                   10      


<210>  195
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  195

Gly Lys Asn Ile Arg Pro Ser 
1               5           


<210>  196
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  196

Asn Ser Arg Asp Ser Ser Gly Asp His Val Ile 
1               5                   10      


<210>  197
<211>  39
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  197
acccgcagca gtggcagcat tgtcagcaac tatgtgcag                              39


<210>  198
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  198
gaggataatc aaagaccctc t                                                 21


<210>  199
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  199
cagtcttatg atagcagcaa tcaggtg                                           27


<210>  200
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  200

Thr Arg Ser Ser Gly Ser Ile Val Ser Asn Tyr Val Gln 
1               5                   10              


<210>  201
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  201

Glu Asp Asn Gln Arg Pro Ser 
1               5           


<210>  202
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  202

Gln Ser Tyr Asp Ser Ser Asn Gln Val 
1               5                   


<210>  203
<211>  39
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  203
tctggaagca gctccaacat cggaagtaat tatgtattc                              39


<210>  204
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  204
aggaataatc agcggccctc a                                                 21


<210>  205
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  205
gcagcatggg atgacagcct gagtggttgg gtg                                    33


<210>  206
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  206

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Phe 
1               5                   10              


<210>  207
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  207

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  208
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  208

Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  209
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  209
agggccagtc agagtgttag aagcaactta gcc                                    33


<210>  210
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  210
ggtgcatcca ccagggccac t                                                 21


<210>  211
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  211
cagcaataca ctgactggcc cact                                              24


<210>  212
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  212

Arg Ala Ser Gln Ser Val Arg Ser Asn Leu Ala 
1               5                   10      


<210>  213
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  213

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  214
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  214

Gln Gln Tyr Thr Asp Trp Pro Thr 
1               5               


<210>  215
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  215
aggtctagtc agagcctcct acatagtcat ggatacagct atttgaat                    48


<210>  216
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  216
ttgggttcta atcgggcctc c                                                 21


<210>  217
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  217
atgcaagttc tgctaactcc gatcacc                                           27


<210>  218
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  218

Arg Ser Ser Gln Ser Leu Leu His Ser His Gly Tyr Ser Tyr Leu Asn 
1               5                   10                  15      


<210>  219
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  219

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  220
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  220

Met Gln Val Leu Leu Thr Pro Ile Thr 
1               5                   


<210>  221
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  221
agttatggca tgcac                                                        15


<210>  222
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  222
gttatatggt atgatggaag taatgaatac tatgcagact ccgtgaaggg c                51


<210>  223
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  223
catgaccaca gtcactacgg ttttgactac                                        30


<210>  224
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  224

Ser Tyr Gly Met His 
1               5   


<210>  225
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  225

Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  226
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  226

His Asp His Ser His Tyr Gly Phe Asp Tyr 
1               5                   10  


<210>  227
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  227
aatgctgaaa tgggtgtgag c                                                 21


<210>  228
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  228
cacctttttt cgaatgacga aaaatcctac agcacatctc tgaagagc                    48


<210>  229
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  229
tcgtttaact ggaactacga ctttgactac                                        30


<210>  230
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  230

Asn Ala Glu Met Gly Val Ser 
1               5           


<210>  231
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  231

His Leu Phe Ser Asn Asp Glu Lys Ser Tyr Ser Thr Ser Leu Lys Ser 
1               5                   10                  15      


<210>  232
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  232

Ser Phe Asn Trp Asn Tyr Asp Phe Asp Tyr 
1               5                   10  


<210>  233
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  233
agtggtagtt actactgggg c                                                 21


<210>  234
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  234
agtatctatt atggtgggaa cacctactac aacccgtccc tcaagagt                    48


<210>  235
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  235
gaactgcgga gggcttttga tatc                                              24


<210>  236
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  236

Ser Gly Ser Tyr Tyr Trp Gly 
1               5           


<210>  237
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  237

Ser Ile Tyr Tyr Gly Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  238
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  238

Glu Leu Arg Arg Ala Phe Asp Ile 
1               5               


<210>  239
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  239
tactatggca tgcac                                                        15


<210>  240
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  240
gttatatggt atgatggaag taataaatac tatgcagact ccgtgaaggg c                51


<210>  241
<211>  36
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  241
gatcatgact acggtgtcct gtactacttt gactac                                 36


<210>  242
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  242

Tyr Tyr Gly Met His 
1               5   


<210>  243
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  243

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  244
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  244

Asp His Asp Tyr Gly Val Leu Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  245
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  245
actagtggag tgggtgtggg c                                                 21


<210>  246
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  246
ctcatttatt ggaatgatga taagcgctac agcccatctc tgaagagc                    48


<210>  247
<211>  39
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  247
agacatggct acgataggat gcgtgatgct tttgatatc                              39


<210>  248
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  248

Thr Ser Gly Val Gly Val Gly 
1               5           


<210>  249
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  249

Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  250
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  250

Arg His Gly Tyr Asp Arg Met Arg Asp Ala Phe Asp Ile 
1               5                   10              


<210>  251
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  251
agctacttta tacac                                                        15


<210>  252
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  252
ataatcaacc ctagtggtgg tagcacaagc tacgcacaga agttccaggg c                51


<210>  253
<211>  54
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  253
gatcaggagg gagcagtggc tggtacagac tactacttct acggtatgga cgtc             54


<210>  254
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  254

Ser Tyr Phe Ile His 
1               5   


<210>  255
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  255

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  256
<211>  18
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  256

Asp Gln Glu Gly Ala Val Ala Gly Thr Asp Tyr Tyr Phe Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  257
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  257
agctatggca tgcac                                                        15


<210>  258
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  258
gttatatcat atgatggaaa taataaatac tatgcagact ccgtgaaggg c                51


<210>  259
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  259
gatgccagtg ggagctccct ctaccttgac tac                                    33


<210>  260
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  260

Ser Tyr Gly Met His 
1               5   


<210>  261
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  261

Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  262
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  262

Asp Ala Ser Gly Ser Ser Leu Tyr Leu Asp Tyr 
1               5                   10      


<210>  263
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  263
aactatggca tgcac                                                        15


<210>  264
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  264
gttatatcat atgatggaag taaaaaatac tatgcagact ccgtgaaggg c                51


<210>  265
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  265
gatgccagtg ggagctccct ctactctgac tac                                    33


<210>  266
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  266

Asn Tyr Gly Met His 
1               5   


<210>  267
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  267

Val Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  268
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  268

Asp Ala Ser Gly Ser Ser Leu Tyr Ser Asp Tyr 
1               5                   10      


<210>  269
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  269
agctatggca tgcac                                                        15


<210>  270
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  270
gttatatcaa aagatggaag ttataaatac tatgcggact ccgtgaaggg c                51


<210>  271
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  271
gatgccagtg ggagctccct ctacttagac tac                                    33


<210>  272
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  272

Ser Tyr Gly Met His 
1               5   


<210>  273
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  273

Val Ile Ser Lys Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  274
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  274

Asp Ala Ser Gly Ser Ser Leu Tyr Leu Asp Tyr 
1               5                   10      


<210>  275
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  275
agctatggca tgcac                                                        15


<210>  276
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  276
gttatatggt atgatggaag taataaatac catgcagact ccgtgaaggg c                51


<210>  277
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  277
gactttgctt acttctacta cggtatggac gtc                                    33


<210>  278
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  278

Ser Tyr Gly Met His 
1               5   


<210>  279
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  279

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr His Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  280
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  280

Asp Phe Ala Tyr Phe Tyr Tyr Gly Met Asp Val 
1               5                   10      


<210>  281
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  281
actagtggag tgggtgtggg c                                                 21


<210>  282
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  282
ctcatttatt ggaatgatga taagcgctac agcccatctc tgaagagc                    48


<210>  283
<211>  39
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  283
agacatggct acgataggat gcgtgatgct tttgatatc                              39


<210>  284
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  284

Thr Ser Gly Val Gly Val Gly 
1               5           


<210>  285
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  285

Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  286
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  286

Arg His Gly Tyr Asp Arg Met Arg Asp Ala Phe Asp Ile 
1               5                   10              


<210>  287
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  287
agtggtggtt actactggag c                                                 21


<210>  288
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  288
tacatctctt acagtgggag cacctactac aacccgtccc tcaagagt                    48


<210>  289
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  289
gagagcccta cggtgactac ggcttttgat atc                                    33


<210>  290
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  290

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  291
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  291

Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  292
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  292

Glu Ser Pro Thr Val Thr Thr Ala Phe Asp Ile 
1               5                   10      


<210>  293
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  293
agtggtggtt acgactggag c                                                 21


<210>  294
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  294
aacatttatt acagtgggag gacctactac aacccgtccc tcaagagt                    48


<210>  295
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  295
gatcgccctt atggaggtaa ttccggctac tactacggta tggacgtc                    48


<210>  296
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  296

Ser Gly Gly Tyr Asp Trp Ser 
1               5           


<210>  297
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  297

Asn Ile Tyr Tyr Ser Gly Arg Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  298
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  298

Asp Arg Pro Tyr Gly Gly Asn Ser Gly Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  299
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  299
agtggtggtt acgactggag c                                                 21


<210>  300
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  300
aacatttatt acagtgggag gacctactac aacccgtccc tcaagagt                    48


<210>  301
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  301
gatcgccctt atggaggtaa ttccggctac tactacggta tggacgtc                    48


<210>  302
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  302

Ser Gly Gly Tyr Asp Trp Ser 
1               5           


<210>  303
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  303

Asn Ile Tyr Tyr Ser Gly Arg Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  304
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  304

Asp Arg Pro Tyr Gly Gly Asn Ser Gly Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  305
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  305
agtagtagtt actattgggg c                                                 21


<210>  306
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  306
agtatctatt atggtgggaa cacctactac aacccgtccc tcaagagt                    48


<210>  307
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  307
gaactgcgga gggcttttga tatc                                              24


<210>  308
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  308

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  309
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  309

Ser Ile Tyr Tyr Gly Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  310
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  310

Glu Leu Arg Arg Ala Phe Asp Ile 
1               5               


<210>  311
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  311
agtggtagtt actactgggg c                                                 21


<210>  312
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  312
agtatctatt atggtgggaa cacctactac aacccgtccc tcaagagt                    48


<210>  313
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  313
gaactgcgga gggcttttga tatc                                              24


<210>  314
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  314

Ser Gly Ser Tyr Tyr Trp Gly 
1               5           


<210>  315
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  315

Ser Ile Tyr Tyr Gly Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  316
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  316

Glu Leu Arg Arg Ala Phe Asp Ile 
1               5               


<210>  317
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  317
agctttggca tgcac                                                        15


<210>  318
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  318
attttatcat ttgatggaaa taataaatac tatgcagact ccgtgaaggg c                51


<210>  319
<211>  36
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  319
gagggggggt ataactggaa ctacgacttt gactac                                 36


<210>  320
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  320

Ser Phe Gly Met His 
1               5   


<210>  321
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  321

Ile Leu Ser Phe Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  322
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  322

Glu Gly Gly Tyr Asn Trp Asn Tyr Asp Phe Asp Tyr 
1               5                   10          


<210>  323
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  323
agtggtggtg actactggag c                                                 21


<210>  324
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  324
tatatctatt acactgggag caccaactac aacccctccc tcaagagt                    48


<210>  325
<211>  30
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  325
tcgggtgtag caatggctcg ctttgactac                                        30


<210>  326
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  326

Ser Gly Gly Asp Tyr Trp Ser 
1               5           


<210>  327
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  327

Tyr Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  328
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  328

Ser Gly Val Ala Met Ala Arg Phe Asp Tyr 
1               5                   10  


<210>  329
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  329
agtggtggct accactggag c                                                 21


<210>  330
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  330
tacatctatt acagtgggag cacctactac aacccgtccc tcaagagt                    48


<210>  331
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  331
gagactacgg tggtaaaggg gtacttcgat ctc                                    33


<210>  332
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  332

Ser Gly Gly Tyr His Trp Ser 
1               5           


<210>  333
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  333

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  334
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  334

Glu Thr Thr Val Val Lys Gly Tyr Phe Asp Leu 
1               5                   10      


<210>  335
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  335
tacgcctgga tgggc                                                        15


<210>  336
<211>  57
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  336
cgtattaaaa gcaaaactga tggtgggaca acagactacg ctgcacccgt gaaaggc          57


<210>  337
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  337
gatggggcac tggcccccca cggctac                                           27


<210>  338
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  338

Tyr Ala Trp Met Gly 
1               5   


<210>  339
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  339

Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  340
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  340

Asp Gly Ala Leu Ala Pro His Gly Tyr 
1               5                   


<210>  341
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  341
agtggtggtt acttctggag c                                                 21


<210>  342
<211>  48
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  342
tacatctatt acagtgggag cacctactac aacccgtccc tcaagagt                    48


<210>  343
<211>  27
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  343
tggggagcag cagccggctt tgactat                                           27


<210>  344
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  344

Ser Gly Gly Tyr Phe Trp Ser 
1               5           


<210>  345
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  345

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  346
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  346

Trp Gly Ala Ala Ala Gly Phe Asp Tyr 
1               5                   


<210>  347
<211>  15
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  347
agctatggca tgcac                                                        15


<210>  348
<211>  51
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  348
gttatatcat atgatggaaa taataaatac tatgcagact ccgtgaaggg c                51


<210>  349
<211>  33
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Polynucleotide encoding the antibody or a portion thereof.

<400>  349
gatgccagtg ggagctccct ctaccttgac tac                                    33


<210>  350
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  350

Ser Tyr Gly Met His 
1               5   


<210>  351
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  351

Val Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  352
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Antibody or a portion thereof.

<400>  352

Asp Ala Ser Gly Ser Ser Leu Tyr Leu Asp Tyr 
1               5                   10      


<210>  353
<211>  1218
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HUMAN JAGGED1

<400>  353

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Arg Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asp Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210>  354
<211>  3657
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  JAGGED1 DNA

<400>  354
atgcgttccc cacggacgcg cggccggtcc gggcgccccc taagcctcct gctcgccctg       60

ctctgtgccc tgcgagccaa ggtgtgtggg gcctcgggtc agttcgagtt ggagatcctg      120

tccatgcaga acgtgaacgg ggagctgcag aacgggaact gctgcggcgg cgcccggaac      180

ccgggagacc gcaagtgcac ccgcgacgag tgtgacacat acttcaaagt gtgcctcaag      240

gagtatcagt cccgcgtcac ggccgggggg ccctgcagct tcggctcagg gtccacgcct      300

gtcatcgggg gcaacacctt caacctcaag gccagccgcg gcaacgaccg caaccgcatc      360

gtgctgcctt tcagtttcgc ctggccgagg tcctatacgt tgcttgtgga ggcgtgggat      420

tccagtaatg acaccgttca acctgacagt attattgaaa aggcttctca ctcgggcatg      480

atcaacccca gccggcagtg gcagacgctg aagcagaaca cgggcgttgc ccactttgag      540

tatcagatcc gcgtgacctg tgatgactac tactatggct ttggctgcaa taagttctgc      600

cgccccagag atgacttctt tggacactat gcctgtgacc agaatggcaa caaaacttgc      660

atggaaggct ggatgggccg cgaatgtaac agagctattt gccgacaagg ctgcagtcct      720

aagcatgggt cttgcaaact cccaggtgac tgcaggtgcc agtacggctg gcaaggcctg      780

tactgtgata agtgcatccc acacccggga tgcgtccacg gcatctgtaa tgagccctgg      840

cagtgcctct gtgagaccaa ctggggcggc cagctctgtg acaaagatct caattactgt      900

gggactcatc agccgtgtct caacggggga acttgtagca acacaggccc tgacaaatat      960

cagtgttcct gccctgaggg gtattcagga cccaactgtg aaattgctga gcacgcctgc     1020

ctctctgatc cctgtcacaa cagaggcagc tgtaaggaga cctccctggg ctttgagtgt     1080

gagtgttccc caggctggac cggccccaca tgctctacaa acattgatga ctgttctcct     1140

aataactgtt cccacggggg cacctgccag gacctggtta acggatttaa gtgtgtgtgc     1200

cccccacagt ggactgggaa aacgtgccag ttagatgcaa atgaatgtga ggccaaacct     1260

tgtgtaaacg ccaaatcctg taagaatctc attgccagct actactgcga ctgtcttccc     1320

ggctggatgg gtcagaattg tgacataaat attaatgact gccttggcca gtgtcagaat     1380

gacgcctcct gtcgggattt ggttaatggt tatcgctgta tctgtccacc tggctatgca     1440

ggcgatcact gtgagagaga catcgatgaa tgtgccagca acccctgttt ggatgggggt     1500

cactgtcaga atgaaatcaa cagattccag tgtctgtgtc ccactggttt ctctggaaac     1560

ctctgtcagc tggacatcga ttattgtgag cctaatccct gccagaacgg tgcccagtgc     1620

tacaaccgtg ccagtgacta tttctgcaag tgccccgagg actatgaggg caagaactgc     1680

tcacacctga aagaccactg ccgcacgacc ccctgtgaag tgattgacag ctgcacagtg     1740

gccatggctt ccaacgacac acctgaaggg gtgcggtata tttcctccaa cgtctgtggt     1800

cctcacggga agtgcaagag tcagtcggga ggcaaattca cctgtgactg taacaaaggc     1860

ttcacgggaa catactgcca tgaaaatatt aatgactgtg agagcaaccc ttgtagaaac     1920

ggtggcactt gcatcgatgg tgtcaactcc tacaagtgca tctgtagtga cggctgggag     1980

ggggcctact gtgaaaccaa tattaatgac tgcagccaga acccctgcca caatgggggc     2040

acgtgtcgcg acctggtcaa tgacttctac tgtgactgta aaaatgggtg gaaaggaaag     2100

acctgccact cacgtgacag tcagtgtgat gaggccacgt gcaacaacgg tggcacctgc     2160

tatgatgagg gggatgcttt taagtgcatg tgtcctggcg gctgggaagg aacaacctgt     2220

aacatagccc gaaacagtag ctgcctgccc aacccctgcc ataatggggg cacatgtgtg     2280

gtcaacggcg agtcctttac gtgcgtctgc aaggaaggct gggaggggcc catctgtgct     2340

cagaatacca atgactgcag ccctcatccc tgttacaaca gcggcacctg tgtggatgga     2400

gacaactggt accggtgcga atgtgccccg ggttttgctg ggcccgactg cagaataaac     2460

atcaatgaat gccagtcttc accttgtgcc tttggagcga cctgtgtgga tgagatcaat     2520

ggctaccggt gtgtctgccc tccagggcac agtggtgcca agtgccagga agtttcaggg     2580

agaccttgca tcaccatggg gagtgtgata ccagatgggg ccaaatggga tgatgactgt     2640

aatacctgcc agtgcctgaa tggacggatc gcctgctcaa aggtctggtg tggccctcga     2700

ccttgcctgc tccacaaagg gcacagcgag tgccccagcg ggcagagctg catccccatc     2760

ctggacgacc agtgcttcgt ccacccctgc actggtgtgg gcgagtgtcg gtcttccagt     2820

ctccagccgg tgaagacaaa gtgcacctct gactcctatt accaggataa ctgtgcgaac     2880

atcacattta cctttaacaa ggagatgatg tcaccaggtc ttactacgga gcacatttgc     2940

agtgaattga ggaatttgaa tattttgaag aatgtttccg ctgaatattc aatctacatc     3000

gcttgcgagc cttccccttc agcgaacaat gaaatacatg tggccatttc tgctgaagat     3060

atacgggatg atgggaaccc gatcaaggaa atcactgaca aaataattga tcttgttagt     3120

aaacgtgatg gaaacagctc gctgattgct gccgttgcag aagtaagagt tcagaggcgg     3180

cctctgaaga acagaacaga tttccttgtt cccttgctga gctctgtctt aactgtggct     3240

tggatctgtt gcttggtgac ggccttctac tggtgcctgc ggaagcggcg gaagccgggc     3300

agccacacac actcagcctc tgaggacaac accaccaaca acgtgcggga gcagctgaac     3360

cagatcaaaa accccattga gaaacatggg gccaacacgg tccccatcaa ggattacgag     3420

aacaagaact ccaaaatgtc taaaataagg acacacaatt ctgaagtaga agaggacgac     3480

atggacaaac accagcagaa agcccggttt gccaagcagc cggcgtatac gctggtagac     3540

agagaagaga agccccccaa cggcacgccg acaaaacacc caaactggac aaacaaacag     3600

gacaacagag acttggaaag tgcccagagc ttaaaccgaa tggagtacat cgtatag        3657


<210>  355
<211>  22
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Leader Sequence

<400>  355

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  356
<211>  66
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Leader Sequence

<400>  356
atggacatga gagtgcctgc acagctgctg ggcctgctgc tgctgtggct gagaggcgcc       60

agatgc                                                                  66


<210>  357
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Leader Sequence

<400>  357

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  358
<211>  57
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Leader Sequence

<400>  358
atggcctggg ctctgctgct cctcaccctc ctcactcagg gcacagggtc ctgggcc          57


