                         SEQUENCE LISTING

<110>  CollPlant Ltd.
       Shoseyov, Oded
       ORR, Nadav
       SEROR MAKNOUZ, Jasmine
       ZARKA, Revital
 
<120>  ADDITIVE MANUFACTURING USING RECOMBINANT COLLAGEN-CONTAINING 
       FORMULATION

<130>  73710

<150>  US 62/517,179
<151>  2017-06-09

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  2
<211>  1366
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  3
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  4
<211>  1366
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  5
<211>  1489
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala His Ala Arg Val Leu Leu Leu Ala Leu Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Ala Val Ala Val Ala Ser Ser Ser Ser Phe Ala Asp Ser Asn Pro 
            20                  25                  30          


Ile Arg Pro Val Thr Asp Arg Ala Ala Ser Thr Leu Ala Gln Leu Gln 
        35                  40                  45              


Glu Glu Gly Gln Val Glu Gly Gln Asp Glu Asp Ile Pro Pro Ile Thr 
    50                  55                  60                  


Cys Val Gln Asn Gly Leu Arg Tyr His Asp Arg Asp Val Trp Lys Pro 
65                  70                  75                  80  


Glu Pro Cys Arg Ile Cys Val Cys Asp Asn Gly Lys Val Leu Cys Asp 
                85                  90                  95      


Asp Val Ile Cys Asp Glu Thr Lys Asn Cys Pro Gly Ala Glu Val Pro 
            100                 105                 110         


Glu Gly Glu Cys Cys Pro Val Cys Pro Asp Gly Ser Glu Ser Pro Thr 
        115                 120                 125             


Asp Gln Glu Thr Thr Gly Val Glu Gly Pro Lys Gly Asp Thr Gly Pro 
    130                 135                 140                 


Arg Gly Pro Arg Gly Pro Ala Gly Pro Pro Gly Arg Asp Gly Ile Pro 
145                 150                 155                 160 


Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
                165                 170                 175     


Pro Pro Gly Leu Gly Gly Asn Phe Ala Pro Gln Leu Ser Tyr Gly Tyr 
            180                 185                 190         


Asp Glu Lys Ser Thr Gly Gly Ile Ser Val Pro Gly Pro Met Gly Pro 
        195                 200                 205             


Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Pro Gln 
    210                 215                 220                 


Gly Phe Gln Gly Pro Pro Gly Glu Pro Gly Glu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Pro Met Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Asn Gly Asp 
                245                 250                 255     


Asp Gly Glu Ala Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Pro Pro 
            260                 265                 270         


Gly Pro Gln Gly Ala Arg Gly Leu Pro Gly Thr Ala Gly Leu Pro Gly 
        275                 280                 285             


Met Lys Gly His Arg Gly Phe Ser Gly Leu Asp Gly Ala Lys Gly Asp 
    290                 295                 300                 


Ala Gly Pro Ala Gly Pro Lys Gly Glu Pro Gly Ser Pro Gly Glu Asn 
305                 310                 315                 320 


Gly Ala Pro Gly Gln Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly 
                325                 330                 335     


Arg Pro Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Asn Asp Gly Ala 
            340                 345                 350         


Thr Gly Ala Ala Gly Pro Pro Gly Pro Thr Gly Pro Ala Gly Pro Pro 
        355                 360                 365             


Gly Phe Pro Gly Ala Val Gly Ala Lys Gly Glu Ala Gly Pro Gln Gly 
    370                 375                 380                 


Pro Arg Gly Ser Glu Gly Pro Gln Gly Val Arg Gly Glu Pro Gly Pro 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ala Gly Pro Ala Gly Asn Pro Gly Ala Asp 
                405                 410                 415     


Gly Gln Pro Gly Ala Lys Gly Ala Asn Gly Ala Pro Gly Ile Ala Gly 
            420                 425                 430         


Ala Pro Gly Phe Pro Gly Ala Arg Gly Pro Ser Gly Pro Gln Gly Pro 
        435                 440                 445             


Gly Gly Pro Pro Gly Pro Lys Gly Asn Ser Gly Glu Pro Gly Ala Pro 
    450                 455                 460                 


Gly Ser Lys Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Pro Val Gly 
465                 470                 475                 480 


Val Gln Gly Pro Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala 
                485                 490                 495     


Arg Gly Glu Pro Gly Pro Thr Gly Leu Pro Gly Pro Pro Gly Glu Arg 
            500                 505                 510         


Gly Gly Pro Gly Ser Arg Gly Phe Pro Gly Ala Asp Gly Val Ala Gly 
        515                 520                 525             


Pro Lys Gly Pro Ala Gly Glu Arg Gly Ser Pro Gly Pro Ala Gly Pro 
    530                 535                 540                 


Lys Gly Ser Pro Gly Glu Ala Gly Arg Pro Gly Glu Ala Gly Leu Pro 
545                 550                 555                 560 


Gly Ala Lys Gly Leu Thr Gly Ser Pro Gly Ser Pro Gly Pro Asp Gly 
                565                 570                 575     


Lys Thr Gly Pro Pro Gly Pro Ala Gly Gln Asp Gly Arg Pro Gly Pro 
            580                 585                 590         


Pro Gly Pro Pro Gly Ala Arg Gly Gln Ala Gly Val Met Gly Phe Pro 
        595                 600                 605             


Gly Pro Lys Gly Ala Ala Gly Glu Pro Gly Lys Ala Gly Glu Arg Gly 
    610                 615                 620                 


Val Pro Gly Pro Pro Gly Ala Val Gly Pro Ala Gly Lys Asp Gly Glu 
625                 630                 635                 640 


Ala Gly Ala Gln Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg 
                645                 650                 655     


Gly Glu Gln Gly Pro Ala Gly Ser Pro Gly Phe Gln Gly Leu Pro Gly 
            660                 665                 670         


Pro Ala Gly Pro Pro Gly Glu Ala Gly Lys Pro Gly Glu Gln Gly Val 
        675                 680                 685             


Pro Gly Asp Leu Gly Ala Pro Gly Pro Ser Gly Ala Arg Gly Glu Arg 
    690                 695                 700                 


Gly Phe Pro Gly Glu Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
705                 710                 715                 720 


Pro Arg Gly Ala Asn Gly Ala Pro Gly Asn Asp Gly Ala Lys Gly Asp 
                725                 730                 735     


Ala Gly Ala Pro Gly Ala Pro Gly Ser Gln Gly Ala Pro Gly Leu Gln 
            740                 745                 750         


Gly Met Pro Gly Glu Arg Gly Ala Ala Gly Leu Pro Gly Pro Lys Gly 
        755                 760                 765             


Asp Arg Gly Asp Ala Gly Pro Lys Gly Ala Asp Gly Ser Pro Gly Lys 
    770                 775                 780                 


Asp Gly Val Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala 
785                 790                 795                 800 


Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro Ser Gly Pro Ala Gly 
                805                 810                 815     


Pro Thr Gly Ala Arg Gly Ala Pro Gly Asp Arg Gly Glu Pro Gly Pro 
            820                 825                 830         


Pro Gly Pro Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro 
        835                 840                 845             


Gly Ala Lys Gly Glu Pro Gly Asp Ala Gly Ala Lys Gly Asp Ala Gly 
    850                 855                 860                 


Pro Pro Gly Pro Ala Gly Pro Ala Gly Pro Pro Gly Pro Ile Gly Asn 
865                 870                 875                 880 


Val Gly Ala Pro Gly Ala Lys Gly Ala Arg Gly Ser Ala Gly Pro Pro 
                885                 890                 895     


Gly Ala Thr Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly 
            900                 905                 910         


Pro Ser Gly Asn Ala Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys 
        915                 920                 925             


Glu Gly Gly Lys Gly Pro Arg Gly Glu Thr Gly Pro Ala Gly Arg Pro 
    930                 935                 940                 


Gly Glu Val Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly 
945                 950                 955                 960 


Ser Pro Gly Ala Asp Gly Pro Ala Gly Ala Pro Gly Thr Pro Gly Pro 
                965                 970                 975     


Gln Gly Ile Ala Gly Gln Arg Gly Val Val Gly Leu Pro Gly Gln Arg 
            980                 985                 990         


Gly Glu Arg Gly Phe Pro Gly Leu  Pro Gly Pro Ser Gly  Glu Pro Gly 
        995                 1000                 1005             


Lys Gln  Gly Pro Ser Gly Ala  Ser Gly Glu Arg Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro Pro Gly  Glu Ser Gly 
    1025                 1030                 1035             


Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser Pro Gly  Arg Asp Gly 
    1040                 1045                 1050             


Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu Thr Gly  Pro Ala Gly 
    1055                 1060                 1065             


Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala Pro Gly  Pro Val Gly 
    1070                 1075                 1080             


Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu Thr Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Ala  Gly Pro Val Gly Pro  Ala Gly Ala Arg Gly  Pro Ala Gly 
    1100                 1105                 1110             


Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu Thr Gly  Glu Gln Gly 
    1115                 1120                 1125             


Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe Ser Gly  Leu Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu Gln Gly  Pro Ser Gly 
    1145                 1150                 1155             


Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro Pro Gly  Ser Ala Gly 
    1160                 1165                 1170             


Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu Pro Gly  Pro Ile Gly 
    1175                 1180                 1185             


Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp Ala Gly  Pro Val Gly 
    1190                 1195                 1200             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Ser 
    1205                 1210                 1215             


Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln Pro Pro  Gln Glu Lys 
    1220                 1225                 1230             


Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala Asp Asp  Ala Asn Val 
    1235                 1240                 1245             


Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr Thr Leu  Lys Ser Leu 
    1250                 1255                 1260             


Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro Glu Gly  Ser Arg Lys 
    1265                 1270                 1275             


Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys Met Cys  His Ser Asp 
    1280                 1285                 1290             


Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro Asn Gln  Gly Cys Asn 
    1295                 1300                 1305             


Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met Glu Thr  Gly Glu Thr 
    1310                 1315                 1320             


Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala Gln Lys  Asn Trp Tyr 
    1325                 1330                 1335             


Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His Val Trp  Phe Gly Glu 
    1340                 1345                 1350             


Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr Gly Gly  Gln Gly Ser 
    1355                 1360                 1365             


Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr Phe Leu  Arg Leu Met 
    1370                 1375                 1380             


Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr His Cys  Lys Asn Ser 
    1385                 1390                 1395             


Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn Leu Lys  Lys Ala Leu 
    1400                 1405                 1410             


Leu Leu  Lys Gly Ser Asn Glu  Ile Glu Ile Arg Ala  Glu Gly Asn 
    1415                 1420                 1425             


Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp Gly Cys  Thr Ser His 
    1430                 1435                 1440             


Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu Tyr Lys  Thr Thr Lys 
    1445                 1450                 1455             


Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala Pro Leu  Asp Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val Gly Pro  Val Cys Phe 
    1475                 1480                 1485             


Leu 
    


<210>  6
<211>  1389
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala His Ala Arg Val Leu Leu Leu Ala Leu Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Ala Val Ala Val Ala Ser Ser Ser Ser Phe Ala Asp Ser Asn Pro 
            20                  25                  30          


Ile Arg Pro Val Thr Asp Arg Ala Ala Ser Thr Leu Ala Gln Leu Leu 
        35                  40                  45              


Gln Glu Glu Thr Val Arg Lys Gly Pro Ala Gly Asp Arg Gly Pro Arg 
    50                  55                  60                  


Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Glu Asp Gly 
65                  70                  75                  80  


Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu 
                85                  90                  95      


Gly Gly Asn Phe Ala Ala Gln Tyr Asp Gly Lys Gly Val Gly Leu Gly 
            100                 105                 110         


Pro Gly Pro Met Gly Leu Met Gly Pro Arg Gly Pro Pro Gly Ala Ala 
        115                 120                 125             


Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Ala Gly Glu Pro Gly 
    130                 135                 140                 


Glu Pro Gly Gln Thr Gly Pro Ala Gly Ala Arg Gly Pro Ala Gly Pro 
145                 150                 155                 160 


Pro Gly Lys Ala Gly Glu Asp Gly His Pro Gly Lys Pro Gly Arg Pro 
                165                 170                 175     


Gly Glu Arg Gly Val Val Gly Pro Gln Gly Ala Arg Gly Phe Pro Gly 
            180                 185                 190         


Thr Pro Gly Leu Pro Gly Phe Lys Gly Ile Arg Gly His Asn Gly Leu 
        195                 200                 205             


Asp Gly Leu Lys Gly Gln Pro Gly Ala Pro Gly Val Lys Gly Glu Pro 
    210                 215                 220                 


Gly Ala Pro Gly Glu Asn Gly Thr Pro Gly Gln Thr Gly Ala Arg Gly 
225                 230                 235                 240 


Leu Pro Gly Glu Arg Gly Arg Val Gly Ala Pro Gly Pro Ala Gly Ala 
                245                 250                 255     


Arg Gly Ser Asp Gly Ser Val Gly Pro Val Gly Pro Ala Gly Pro Ile 
            260                 265                 270         


Gly Ser Ala Gly Pro Pro Gly Phe Pro Gly Ala Pro Gly Pro Lys Gly 
        275                 280                 285             


Glu Ile Gly Ala Val Gly Asn Ala Gly Pro Thr Gly Pro Ala Gly Pro 
    290                 295                 300                 


Arg Gly Glu Val Gly Leu Pro Gly Leu Ser Gly Pro Val Gly Pro Pro 
305                 310                 315                 320 


Gly Asn Pro Gly Ala Asn Gly Leu Thr Gly Ala Lys Gly Ala Ala Gly 
                325                 330                 335     


Leu Pro Gly Val Ala Gly Ala Pro Gly Leu Pro Gly Pro Arg Gly Ile 
            340                 345                 350         


Pro Gly Pro Val Gly Ala Ala Gly Ala Thr Gly Ala Arg Gly Leu Val 
        355                 360                 365             


Gly Glu Pro Gly Pro Ala Gly Ser Lys Gly Glu Ser Gly Asn Lys Gly 
    370                 375                 380                 


Glu Pro Gly Ser Ala Gly Pro Gln Gly Pro Pro Gly Pro Ser Gly Glu 
385                 390                 395                 400 


Glu Gly Lys Arg Gly Pro Asn Gly Glu Ala Gly Ser Ala Gly Pro Pro 
                405                 410                 415     


Gly Pro Pro Gly Leu Arg Gly Ser Pro Gly Ser Arg Gly Leu Pro Gly 
            420                 425                 430         


Ala Asp Gly Arg Ala Gly Val Met Gly Pro Pro Gly Ser Arg Gly Ala 
        435                 440                 445             


Ser Gly Pro Ala Gly Val Arg Gly Pro Asn Gly Asp Ala Gly Arg Pro 
    450                 455                 460                 


Gly Glu Pro Gly Leu Met Gly Pro Arg Gly Leu Pro Gly Ser Pro Gly 
465                 470                 475                 480 


Asn Ile Gly Pro Ala Gly Lys Glu Gly Pro Val Gly Leu Pro Gly Ile 
                485                 490                 495     


Asp Gly Arg Pro Gly Pro Ile Gly Pro Ala Gly Ala Arg Gly Glu Pro 
            500                 505                 510         


Gly Asn Ile Gly Phe Pro Gly Pro Lys Gly Pro Thr Gly Asp Pro Gly 
        515                 520                 525             


Lys Asn Gly Asp Lys Gly His Ala Gly Leu Ala Gly Ala Arg Gly Ala 
    530                 535                 540                 


Pro Gly Pro Asp Gly Asn Asn Gly Ala Gln Gly Pro Pro Gly Pro Gln 
545                 550                 555                 560 


Gly Val Gln Gly Gly Lys Gly Glu Gln Gly Pro Ala Gly Pro Pro Gly 
                565                 570                 575     


Phe Gln Gly Leu Pro Gly Pro Ser Gly Pro Ala Gly Glu Val Gly Lys 
            580                 585                 590         


Pro Gly Glu Arg Gly Leu His Gly Glu Phe Gly Leu Pro Gly Pro Ala 
        595                 600                 605             


Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly Glu Ser Gly Ala Ala Gly 
    610                 615                 620                 


Pro Thr Gly Pro Ile Gly Ser Arg Gly Pro Ser Gly Pro Pro Gly Pro 
625                 630                 635                 640 


Asp Gly Asn Lys Gly Glu Pro Gly Val Val Gly Ala Val Gly Thr Ala 
                645                 650                 655     


Gly Pro Ser Gly Pro Ser Gly Leu Pro Gly Glu Arg Gly Ala Ala Gly 
            660                 665                 670         


Ile Pro Gly Gly Lys Gly Glu Lys Gly Glu Pro Gly Leu Arg Gly Glu 
        675                 680                 685             


Ile Gly Asn Pro Gly Arg Asp Gly Ala Arg Gly Ala His Gly Ala Val 
    690                 695                 700                 


Gly Ala Pro Gly Pro Ala Gly Ala Thr Gly Asp Arg Gly Glu Ala Gly 
705                 710                 715                 720 


Ala Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Ser Pro Gly Glu 
                725                 730                 735     


Arg Gly Glu Val Gly Pro Ala Gly Pro Asn Gly Phe Ala Gly Pro Ala 
            740                 745                 750         


Gly Ala Ala Gly Gln Pro Gly Ala Lys Gly Glu Arg Gly Gly Lys Gly 
        755                 760                 765             


Pro Lys Gly Glu Asn Gly Val Val Gly Pro Thr Gly Pro Val Gly Ala 
    770                 775                 780                 


Ala Gly Pro Ala Gly Pro Asn Gly Pro Pro Gly Pro Ala Gly Ser Arg 
785                 790                 795                 800 


Gly Asp Gly Gly Pro Pro Gly Met Thr Gly Phe Pro Gly Ala Ala Gly 
                805                 810                 815     


Arg Thr Gly Pro Pro Gly Pro Ser Gly Ile Ser Gly Pro Pro Gly Pro 
            820                 825                 830         


Pro Gly Pro Ala Gly Lys Glu Gly Leu Arg Gly Pro Arg Gly Asp Gln 
        835                 840                 845             


Gly Pro Val Gly Arg Thr Gly Glu Val Gly Ala Val Gly Pro Pro Gly 
    850                 855                 860                 


Phe Ala Gly Glu Lys Gly Pro Ser Gly Glu Ala Gly Thr Ala Gly Pro 
865                 870                 875                 880 


Pro Gly Thr Pro Gly Pro Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu 
                885                 890                 895     


Gly Leu Pro Gly Ser Arg Gly Glu Arg Gly Leu Pro Gly Val Ala Gly 
            900                 905                 910         


Ala Val Gly Glu Pro Gly Pro Leu Gly Ile Ala Gly Pro Pro Gly Ala 
        915                 920                 925             


Arg Gly Pro Pro Gly Ala Val Gly Ser Pro Gly Val Asn Gly Ala Pro 
    930                 935                 940                 


Gly Glu Ala Gly Arg Asp Gly Asn Pro Gly Asn Asp Gly Pro Pro Gly 
945                 950                 955                 960 


Arg Asp Gly Gln Pro Gly His Lys Gly Glu Arg Gly Tyr Pro Gly Asn 
                965                 970                 975     


Ile Gly Pro Val Gly Ala Ala Gly Ala Pro Gly Pro His Gly Pro Val 
            980                 985                 990         


Gly Pro Ala Gly Lys His Gly Asn  Arg Gly Glu Thr Gly  Pro Ser Gly 
        995                 1000                 1005             


Pro Val  Gly Pro Ala Gly Ala  Val Gly Pro Arg Gly  Pro Ser Gly 
    1010                 1015                 1020             


Pro Gln  Gly Ile Arg Gly Asp  Lys Gly Glu Pro Gly  Glu Lys Gly 
    1025                 1030                 1035             


Pro Arg  Gly Leu Pro Gly Phe  Lys Gly His Asn Gly  Leu Gln Gly 
    1040                 1045                 1050             


Leu Pro  Gly Ile Ala Gly His  His Gly Asp Gln Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ser Val  Gly Pro Ala Gly Pro  Arg Gly Pro Ala Gly  Pro Ser Gly 
    1070                 1075                 1080             


Pro Ala  Gly Lys Asp Gly Arg  Thr Gly His Pro Gly  Thr Val Gly 
    1085                 1090                 1095             


Pro Ala  Gly Ile Arg Gly Pro  Gln Gly His Gln Gly  Pro Ala Gly 
    1100                 1105                 1110             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Val Ser Gly 
    1115                 1120                 1125             


Gly Gly  Tyr Asp Phe Gly Tyr  Asp Gly Asp Phe Tyr  Arg Ala Asp 
    1130                 1135                 1140             


Gln Pro  Arg Ser Ala Pro Ser  Leu Arg Pro Lys Asp  Tyr Glu Val 
    1145                 1150                 1155             


Asp Ala  Thr Leu Lys Ser Leu  Asn Asn Gln Ile Glu  Thr Leu Leu 
    1160                 1165                 1170             


Thr Pro  Glu Gly Ser Arg Lys  Asn Pro Ala Arg Thr  Cys Arg Asp 
    1175                 1180                 1185             


Leu Arg  Leu Ser His Pro Glu  Trp Ser Ser Gly Tyr  Tyr Trp Ile 
    1190                 1195                 1200             


Asp Pro  Asn Gln Gly Cys Thr  Met Glu Ala Ile Lys  Val Tyr Cys 
    1205                 1210                 1215             


Asp Phe  Pro Thr Gly Glu Thr  Cys Ile Arg Ala Gln  Pro Glu Asn 
    1220                 1225                 1230             


Ile Pro  Ala Lys Asn Trp Tyr  Arg Ser Ser Lys Asp  Lys Lys His 
    1235                 1240                 1245             


Val Trp  Leu Gly Glu Thr Ile  Asn Ala Gly Ser Gln  Phe Glu Tyr 
    1250                 1255                 1260             


Asn Val  Glu Gly Val Thr Ser  Lys Glu Met Ala Thr  Gln Leu Ala 
    1265                 1270                 1275             


Phe Met  Arg Leu Leu Ala Asn  Tyr Ala Ser Gln Asn  Ile Thr Tyr 
    1280                 1285                 1290             


His Cys  Lys Asn Ser Ile Ala  Tyr Met Asp Glu Glu  Thr Gly Asn 
    1295                 1300                 1305             


Leu Lys  Lys Ala Val Ile Leu  Gln Gly Ser Asn Asp  Val Glu Leu 
    1310                 1315                 1320             


Val Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Thr Val  Leu Val Asp 
    1325                 1330                 1335             


Gly Cys  Ser Lys Lys Thr Asn  Glu Trp Gly Lys Thr  Ile Ile Glu 
    1340                 1345                 1350             


Tyr Lys  Thr Asn Lys Pro Ser  Arg Leu Pro Phe Leu  Asp Ile Ala 
    1355                 1360                 1365             


Pro Leu  Asp Ile Gly Gly Ala  Asp His Glu Phe Phe  Val Asp Ile 
    1370                 1375                 1380             


Gly Pro  Val Cys Phe Lys 
    1385                 


<210>  7
<211>  5927
<212>  DNA
<213>  Homo sapiens

<400>  7
tcgtcggagc agacgggagt ttctcctcgg ggtcggagca ggaggcacgc ggagtgtgag       60

gccacgcatg agcggacgct aaccccctcc ccagccacaa agagtctaca tgtctagggt      120

ctagacatgt tcagctttgt ggacctccgg ctcctgctcc tcttagcggc caccgccctc      180

ctgacgcacg gccaagagga aggccaagtc gagggccaag acgaagacat cccaccaatc      240

acctgcgtac agaacggcct caggtaccat gaccgagacg tgtggaaacc cgagccctgc      300

cggatctgcg tctgcgacaa cggcaaggtg ttgtgcgatg acgtgatctg tgacgagacc      360

aagaactgcc ccggcgccga agtccccgag ggcgagtgct gtcccgtctg ccccgacggc      420

tcagagtcac ccaccgacca agaaaccacc ggcgtcgagg gacccaaggg agacactggc      480

ccccgaggcc caaggggacc cgcaggcccc cctggccgag atggcatccc tggacagcct      540

ggacttcccg gaccccccgg accccccgga cctcccggac cccctggcct cggaggaaac      600

tttgctcccc agctgtctta tggctatgat gagaaatcaa ccggaggaat ttccgtgcct      660

ggccccatgg gtccctctgg tcctcgtggt ctccctggcc cccctggtgc acctggtccc      720

caaggcttcc aaggtccccc tggtgagcct ggcgagcctg gagcttcagg tcccatgggt      780

ccccgaggtc ccccaggtcc ccctggaaag aatggagatg atggggaagc tggaaaacct      840

ggtcgtcctg gtgagcgtgg gcctcctggg cctcagggtg ctcgaggatt gcccggaaca      900

gctggcctcc ctggaatgaa gggacacaga ggtttcagtg gtttggatgg tgccaaggga      960

gatgctggtc ctgctggtcc taagggtgag cctggcagcc ctggtgaaaa tggagctcct     1020

ggtcagatgg gcccccgtgg cctgcctggt gagagaggtc gccctggagc ccctggccct     1080

gctggtgctc gtggaaatga tggtgctact ggtgctgccg ggccccctgg tcccaccggc     1140

cccgctggtc ctcctggctt ccctggtgct gttggtgcta agggtgaagc tggtccccaa     1200

gggccccgag gctctgaagg tccccagggt gtgcgtggtg agcctggccc ccctggccct     1260

gctggtgctg ctggccctgc tggaaaccct ggtgctgatg gacagcctgg tgctaaaggt     1320

gccaatggtg ctcctggtat tgctggtgct cctggcttcc ctggtgcccg aggcccctct     1380

ggaccccagg gccccggcgg ccctcctggt cccaagggta acagcggtga acctggtgct     1440

cctggcagca aaggagacac tggtgctaag ggagagcctg gccctgttgg tgttcaagga     1500

ccccctggcc ctgctggaga ggaaggaaag cgaggagctc gaggtgaacc cggacccact     1560

ggcctgcccg gaccccctgg cgagcgtggt ggacctggta gccgtggttt ccctggcgca     1620

gatggtgttg ctggtcccaa gggtcccgct ggtgaacgtg gttctcctgg ccctgctggc     1680

cccaaaggat ctcctggtga agctggtcgt cccggtgaag ctggtctgcc tggtgccaag     1740

ggtctgactg gaagccctgg cagccctggt cctgatggca aaactggccc ccctggtccc     1800

gccggtcaag atggtcgccc cggaccccca ggcccacctg gtgcccgtgg tcaggctggt     1860

gtgatgggat tccctggacc taaaggtgct gctggagagc ccggcaaggc tggagagcga     1920

ggtgttcccg gaccccctgg cgctgtcggt cctgctggca aagatggaga ggctggagct     1980

cagggacccc ctggccctgc tggtcccgct ggcgagagag gtgaacaagg ccctgctggc     2040

tcccccggat tccagggtct ccctggtcct gctggtcctc caggtgaagc aggcaaacct     2100

ggtgaacagg gtgttcctgg agaccttggc gcccctggcc cctctggagc aagaggcgag     2160

agaggtttcc ctggcgagcg tggtgtgcaa ggtccccctg gtcctgctgg tccccgaggg     2220

gccaacggtg ctcccggcaa cgatggtgct aagggtgatg ctggtgcccc tggagctccc     2280

ggtagccagg gcgcccctgg ccttcaggga atgcctggtg aacgtggtgc agctggtctt     2340

ccagggccta agggtgacag aggtgatgct ggtcccaaag gtgctgatgg ctctcctggc     2400

aaagatggcg tccgtggtct gactggcccc attggtcctc ctggccctgc tggtgcccct     2460

ggtgacaagg gtgaaagtgg tcccagcggc cctgctggtc ccactggagc tcgtggtgcc     2520

cccggagacc gtggtgagcc tggtcccccc ggccctgctg gctttgctgg cccccctggt     2580

gctgacggcc aacctggtgc taaaggcgaa cctggtgatg ctggtgctaa aggcgatgct     2640

ggtccccctg gccctgccgg acccgctgga ccccctggcc ccattggtaa tgttggtgct     2700

cctggagcca aaggtgctcg cggcagcgct ggtccccctg gtgctactgg tttccctggt     2760

gctgctggcc gagtcggtcc tcctggcccc tctggaaatg ctggaccccc tggccctcct     2820

ggtcctgctg gcaaagaagg cggcaaaggt ccccgtggtg agactggccc tgctggacgt     2880

cctggtgaag ttggtccccc tggtccccct ggccctgctg gcgagaaagg atcccctggt     2940

gctgatggtc ctgctggtgc tcctggtact cccgggcctc aaggtattgc tggacagcgt     3000

ggtgtggtcg gcctgcctgg tcagagagga gagagaggct tccctggtct tcctggcccc     3060

tctggtgaac ctggcaaaca aggtccctct ggagcaagtg gtgaacgtgg tccccctggt     3120

cccatgggcc cccctggatt ggctggaccc cctggtgaat ctggacgtga gggggctcct     3180

ggtgccgaag gttcccctgg acgagacggt tctcctggcg ccaagggtga ccgtggtgag     3240

accggccccg ctggaccccc tggtgctcct ggtgctcctg gtgcccctgg ccccgttggc     3300

cctgctggca agagtggtga tcgtggtgag actggtcctg ctggtcccgc cggtcctgtc     3360

ggccctgttg gcgcccgtgg ccccgccgga ccccaaggcc cccgtggtga caagggtgag     3420

acaggcgaac agggcgacag aggcataaag ggtcaccgtg gcttctctgg cctccagggt     3480

ccccctggcc ctcctggctc tcctggtgaa caaggtccct ctggagcctc tggtcctgct     3540

ggtccccgag gtccccctgg ctctgctggt gctcctggca aagatggact caacggtctc     3600

cctggcccca ttgggccccc tggtcctcgc ggtcgcactg gtgatgctgg tcctgttggt     3660

ccccccggcc ctcctggacc tcctggtccc cctggtcctc ccagcgctgg tttcgacttc     3720

agcttcctgc cccagccacc tcaagagaag gctcacgatg gtggccgcta ctaccgggct     3780

gatgatgcca atgtggttcg tgaccgtgac ctcgaggtgg acaccaccct caagagcctg     3840

agccagcaga tcgagaacat ccggagccca gagggcagcc gcaagaaccc cgcccgcacc     3900

tgccgtgacc tcaagatgtg ccactctgac tggaagagtg gagagtactg gattgacccc     3960

aaccaaggct gcaacctgga tgccatcaaa gtcttctgca acatggagac tggtgagacc     4020

tgcgtgtacc ccactcagcc cagtgtggcc cagaagaact ggtacatcag caagaacccc     4080

aaggacaaga ggcatgtctg gttcggcgag agcatgaccg atggattcca gttcgagtat     4140

ggcggccagg gctccgaccc tgccgatgtg gccatccagc tgaccttcct gcgcctgatg     4200

tccaccgagg cctcccagaa catcacctac cactgcaaga acagcgtggc ctacatggac     4260

cagcagactg gcaacctcaa gaaggccctg ctcctccagg gctccaacga gatcgagatc     4320

cgcgccgagg gcaacagccg cttcacctac agcgtcactg tcgatggctg cacgagtcac     4380

accggagcct ggggcaagac agtgattgaa tacaaaacca ccaagacctc ccgcctgccc     4440

atcatcgatg tggccccctt ggacgttggt gccccagacc aggaattcgg cttcgacgtt     4500

ggccctgtct gcttcctgta aactccctcc atcccaacct ggctccctcc cacccaacca     4560

actttccccc caacccggaa acagacaagc aacccaaact gaaccccctc aaaagccaaa     4620

aaatgggaga caatttcaca tggactttgg aaaatatttt tttcctttgc attcatctct     4680

caaacttagt ttttatcttt gaccaaccga acatgaccaa aaaccaaaag tgcattcaac     4740

cttaccaaaa aaaaaaaaaa aaaaagaata aataaataac tttttaaaaa aggaagcttg     4800

gtccacttgc ttgaagaccc atgcgggggt aagtcccttt ctgcccgttg ggcttatgaa     4860

accccaatgc tgccctttct gctcctttct ccacaccccc cttggggcct cccctccact     4920

ccttcccaaa tctgtctccc cagaagacac aggaaacaat gtattgtctg cccagcaatc     4980

aaaggcaatg ctcaaacacc caagtggccc ccaccctcag cccgctcctg cccgcccagc     5040

acccccaggc cctgggggac ctggggttct cagactgcca aagaagcctt gccatctggc     5100

gctcccatgg ctcttgcaac atctcccctt cgtttttgag ggggtcatgc cgggggagcc     5160

accagcccct cactgggttc ggaggagagt caggaagggc cacgacaaag cagaaacatc     5220

ggatttgggg aacgcgtgtc aatcccttgt gccgcagggc tgggcgggag agactgttct     5280

gttccttgtg taactgtgtt gctgaaagac tacctcgttc ttgtcttgat gtgtcaccgg     5340

ggcaactgcc tgggggcggg gatgggggca gggtggaagc ggctccccat tttataccaa     5400

aggtgctaca tctatgtgat gggtggggtg gggagggaat cactggtgct atagaaattg     5460

agatgccccc ccaggccagc aaatgttcct ttttgttcaa agtctatttt tattccttga     5520

tatttttctt tttttttttt tttttttgtg gatggggact tgtgaatttt tctaaaggtg     5580

ctatttaaca tgggaggaga gcgtgtgcgg ctccagccca gcccgctgct cactttccac     5640

cctctctcca cctgcctctg gcttctcagg cctctgctct ccgacctctc tcctctgaaa     5700

ccctcctcca cagctgcagc ccatcctccc ggctccctcc tagtctgtcc tgcgtcctct     5760

gtccccgggt ttcagagaca acttcccaaa gcacaaagca gtttttcccc ctaggggtgg     5820

gaggaagcaa aagactctgt acctattttg tatgtgtata ataatttgag atgtttttaa     5880

ttattttgat tgctggaata aagcatgtgg aaatgaccca aacataa                   5927


<210>  8
<211>  5411
<212>  DNA
<213>  Homo sapiens

<400>  8
gtgtcccata gtgtttccaa acttggaaag ggcgggggag ggcgggagga tgcggagggc       60

ggaggtatgc agacaacgag tcagagtttc cccttgaaag cctcaaaagt gtccacgtcc      120

tcaaaaagaa tggaaccaat ttaagaagcc agccccgtgg ccacgtccct tcccccattc      180

gctccctcct ctgcgccccc gcaggctcct cccagctgtg gctgcccggg cccccagccc      240

cagccctccc attggtggag gcccttttgg aggcacccta gggccaggga aacttttgcc      300

gtataaatag ggcagatccg ggctttatta ttttagcacc acggcagcag gaggtttcgg      360

ctaagttgga ggtactggcc acgactgcat gcccgcgccc gccaggtgat acctccgccg      420

gtgacccagg ggctctgcga cacaaggagt ctgcatgtct aagtgctaga catgctcagc      480

tttgtggata cgcggacttt gttgctgctt gcagtaacct tatgcctagc aacatgccaa      540

tctttacaag aggaaactgt aagaaagggc ccagccggag atagaggacc acgtggagaa      600

aggggtccac caggcccccc aggcagagat ggtgaagatg gtcccacagg ccctcctggt      660

ccacctggtc ctcctggccc ccctggtctc ggtgggaact ttgctgctca gtatgatgga      720

aaaggagttg gacttggccc tggaccaatg ggcttaatgg gacctagagg cccacctggt      780

gcagctggag ccccaggccc tcaaggtttc caaggacctg ctggtgagcc tggtgaacct      840

ggtcaaactg gtcctgcagg tgctcgtggt ccagctggcc ctcctggcaa ggctggtgaa      900

gatggtcacc ctggaaaacc cggacgacct ggtgagagag gagttgttgg accacagggt      960

gctcgtggtt tccctggaac tcctggactt cctggcttca aaggcattag gggacacaat     1020

ggtctggatg gattgaaggg acagcccggt gctcctggtg tgaagggtga acctggtgcc     1080

cctggtgaaa atggaactcc aggtcaaaca ggagcccgtg ggcttcctgg tgagagagga     1140

cgtgttggtg cccctggccc agctggtgcc cgtggcagtg atggaagtgt gggtcccgtg     1200

ggtcctgctg gtcccattgg gtctgctggc cctccaggct tcccaggtgc ccctggcccc     1260

aagggtgaaa ttggagctgt tggtaacgct ggtcctgctg gtcccgccgg tccccgtggt     1320

gaagtgggtc ttccaggcct ctccggcccc gttggacctc ctggtaatcc tggagcaaac     1380

ggccttactg gtgccaaggg tgctgctggc cttcccggcg ttgctggggc tcccggcctc     1440

cctggacccc gcggtattcc tggccctgtt ggtgctgccg gtgctactgg tgccagagga     1500

cttgttggtg agcctggtcc agctggctcc aaaggagaga gcggtaacaa gggtgagccc     1560

ggctctgctg ggccccaagg tcctcctggt cccagtggtg aagaaggaaa gagaggccct     1620

aatggggaag ctggatctgc cggccctcca ggacctcctg ggctgagagg tagtcctggt     1680

tctcgtggtc ttcctggagc tgatggcaga gctggcgtca tgggccctcc tggtagtcgt     1740

ggtgcaagtg gccctgctgg agtccgagga cctaatggag atgctggtcg ccctggggag     1800

cctggtctca tgggacccag aggtcttcct ggttcccctg gaaatatcgg ccccgctgga     1860

aaagaaggtc ctgtcggcct ccctggcatc gacggcaggc ctggcccaat tggcccagct     1920

ggagcaagag gagagcctgg caacattgga ttccctggac ccaaaggccc cactggtgat     1980

cctggcaaaa acggtgataa aggtcatgct ggtcttgctg gtgctcgggg tgctccaggt     2040

cctgatggaa acaatggtgc tcagggacct cctggaccac agggtgttca aggtggaaaa     2100

ggtgaacagg gtccccctgg tcctccaggc ttccagggtc tgcctggccc ctcaggtccc     2160

gctggtgaag ttggcaaacc aggagaaagg ggtctccatg gtgagtttgg tctccctggt     2220

cctgctggtc caagagggga acgcggtccc ccaggtgaga gtggtgctgc cggtcctact     2280

ggtcctattg gaagccgagg tccttctgga cccccagggc ctgatggaaa caagggtgaa     2340

cctggtgtgg ttggtgctgt gggcactgct ggtccatctg gtcctagtgg actcccagga     2400

gagaggggtg ctgctggcat acctggaggc aagggagaaa agggtgaacc tggtctcaga     2460

ggtgaaattg gtaaccctgg cagagatggt gctcgtggtg ctcctggtgc tgtaggtgcc     2520

cctggtcctg ctggagccac aggtgaccgg ggcgaagctg gggctgctgg tcctgctggt     2580

cctgctggtc ctcggggaag ccctggtgaa cgtggtgagg tcggtcctgc tggccccaat     2640

ggatttgctg gtcctgctgg tgctgctggt caacctggtg ctaaaggaga aagaggagcc     2700

aaagggccta agggtgaaaa cggtgttgtt ggtcccacag gccccgttgg agctgctggc     2760

ccagctggtc caaatggtcc ccccggtcct gctggaagtc gtggtgatgg aggcccccct     2820

ggtatgactg gtttccctgg tgctgctgga cggactggtc ccccaggacc ctctggtatt     2880

tctggccctc ctggtccccc tggtcctgct gggaaagaag ggcttcgtgg tcctcgtggt     2940

gaccaaggtc cagttggccg aactggagaa gtaggtgcag ttggtccccc tggcttcgct     3000

ggtgagaagg gtccctctgg agaggctggt actgctggac ctcctggcac tccaggtcct     3060

cagggtcttc ttggtgctcc tggtattctg ggtctccctg gctcgagagg tgaacgtggt     3120

ctaccaggtg ttgctggtgc tgtgggtgaa cctggtcctc ttggcattgc cggccctcct     3180

ggggcccgtg gtcctcctgg tgctgtgggt agtcctggag tcaacggtgc tcctggtgaa     3240

gctggtcgtg atggcaaccc tgggaacgat ggtcccccag gtcgcgatgg tcaacccgga     3300

cacaagggag agcgcggtta ccctggcaat attggtcccg ttggtgctgc aggtgcacct     3360

ggtcctcatg gccccgtggg tcctgctggc aaacatggaa accgtggtga aactggtcct     3420

tctggtcctg ttggtcctgc tggtgctgtt ggcccaagag gtcctagtgg cccacaaggc     3480

attcgtggcg ataagggaga gcccggtgaa aaggggccca gaggtcttcc tggcttaaag     3540

ggacacaatg gattgcaagg tctgcctggt atcgctggtc accatggtga tcaaggtgct     3600

cctggctccg tgggtcctgc tggtcctagg ggccctgctg gtccttctgg ccctgctgga     3660

aaagatggtc gcactggaca tcctggtaca gttggacctg ctggcattcg aggccctcag     3720

ggtcaccaag gccctgctgg cccccctggt ccccctggcc ctcctggacc tccaggtgta     3780

agcggtggtg gttatgactt tggttacgat ggagacttct acagggctga ccagcctcgc     3840

tcagcacctt ctctcagacc caaggactat gaagttgatg ctactctgaa gtctctcaac     3900

aaccagattg agacccttct tactcctgaa ggctctagaa agaacccagc tcgcacatgc     3960

cgtgacttga gactcagcca cccagagtgg agcagtggtt actactggat tgaccctaac     4020

caaggatgca ctatggatgc tatcaaagta tactgtgatt tctctactgg cgaaacctgt     4080

atccgggccc aacctgaaaa catcccagcc aagaactggt ataggagctc caaggacaag     4140

aaacacgtct ggctaggaga aactatcaat gctggcagcc agtttgaata taatgtagaa     4200

ggagtgactt ccaaggaaat ggctacccaa cttgccttca tgcgcctgct ggccaactat     4260

gcctctcaga acatcaccta ccactgcaag aacagcattg catacatgga tgaggagact     4320

ggcaacctga aaaaggctgt cattctacag ggctctaatg atgttgaact tgttgctgag     4380

ggcaacagca ggttcactta cactgttctt gtagatggct gctctaaaaa gacaaatgaa     4440

tggggaaaga caatcattga atacaaaaca aataagccat cacgcctgcc cttccttgat     4500

attgcacctt tggacatcgg tggtgctgac caggaattct ttgtggacat tggcccagtc     4560

tgtttcaaat aaatgaactc aatctaaatt aaaaaagaaa gaaatttgaa aaaactttct     4620

ctttgccatt tcttcttctt cttttttaac tgaaagctga atccttccat ttcttctgca     4680

catctacttg cttaaattgt gggcaaaaga gaaaaagaag gattgatcag agcattgtgc     4740

aatacagttt cattaactcc ttcccccgct cccccaaaaa tttgaatttt tttttcaaca     4800

ctcttacacc tgttatggaa aatgtcaacc tttgtaagaa aaccaaaata aaaattgaaa     4860

aataaaaacc ataaacattt gcaccacttg tggcttttga atatcttcca cagagggaag     4920

tttaaaaccc aaacttccaa aggtttaaac tacctcaaaa cactttccca tgagtgtgat     4980

ccacattgtt aggtgctgac ctagacagag atgaactgag gtccttgttt tgttttgttc     5040

ataatacaaa ggtgctaatt aatagtattt cagatacttg aagaatgttg atggtgctag     5100

aagaatttga gaagaaatac tcctgtattg agttgtatcg tgtggtgtat tttttaaaaa     5160

atttgattta gcattcatat tttccatctt attcccaatt aaaagtatgc agattatttg     5220

cccaaatctt cttcagattc agcatttgtt ctttgccagt ctcattttca tcttcttcca     5280

tggttccaca gaagctttgt ttcttgggca agcagaaaaa ttaaattgta cctattttgt     5340

atatgtgaga tgtttaaata aattgtgaaa aaaatgaaat aaagcatgtt tggttttcca     5400

aaagaacata t                                                          5411


<210>  9
<211>  4467
<212>  DNA
<213>  Homo sapiens

<400>  9
atggctcacg ctcgtgttct cctcctcgct ctcgctgttt tggcaacagc tgctgtggct       60

gtggcttcta gttcttcttt tgctgattca aaccctatta gacctgttac tgatagagca      120

gcttccactt tggctcaatt gcaagaggag ggccaggttg agggccaaga tgaggatatc      180

cctccaatta catgcgtgca aaatggcttg cgttaccacg atagggatgt gtggaaacct      240

gaaccttgtc gtatctgtgt gtgtgataac ggcaaggtgc tctgcgatga tgttatctgc      300

gatgagacaa aaaattgccc tggcgctgaa gttcctgagg gcgagtgttg ccctgtgtgc      360

cctgatggtt ccgagtcccc aactgatcag gaaactactg gcgtggaggg cccaaaagga      420

gatactggtc cacgtggtcc taggggtcca gcaggtcctc caggtagaga tggtattcca      480

ggccagcctg gattgccagg accaccaggc ccacctggcc caccaggacc tcctggtctt      540

ggtggaaatt tcgctccaca actctcttat ggctatgatg agaagtcaac aggtggtatt      600

tccgttccag gtcctatggg accatccgga ccaagaggtc tcccaggtcc tccaggtgct      660

cctggacctc aaggctttca aggacctcca ggcgaaccag gagaaccagg cgcttctgga      720

ccaatgggcc caaggggacc acctggccca ccaggaaaaa atggcgatga tggcgaagct      780

ggaaagcctg gtcgtcctgg agagagaggt cctcctggcc cacagggtgc aagaggcttg      840

ccaggaactg ctggcttgcc tggaatgaag ggacataggg gcttctccgg cctcgatggc      900

gctaagggtg atgctggccc tgctggacca aagggcgagc caggttcccc tggagaaaac      960

ggtgctcctg gacaaatggg tcctcgtgga cttccaggag aaaggggtcg tccaggcgct     1020

ccaggaccag caggtgctag gggaaacgat ggtgcaacag gcgctgctgg ccctcctggc     1080

ccaactggtc ctgctggccc tccaggattc ccaggcgcag ttggagctaa aggagaagca     1140

ggaccacagg gccctagggg ttctgaagga cctcagggtg ttagaggtga accaggtcct     1200

ccaggcccag ctggagcagc tggtccagca ggaaatccag gtgctgatgg tcaacctgga     1260

gctaagggcg ctaatggcgc accaggtatc gcaggcgcac caggttttcc tggcgctaga     1320

ggcccaagtg gtcctcaagg accaggtgga ccaccaggtc caaaaggcaa ttctggcgaa     1380

cctggcgctc caggttctaa aggagatact ggtgctaaag gcgaaccagg acctgttggt     1440

gttcagggtc ctcctggtcc tgctggagaa gaaggaaaaa gaggtgctcg tggagaacca     1500

ggaccaactg gacttcctgg acctcctggt gaacgtggcg gacctggctc aaggggtttc     1560

cctggagctg atggagtggc aggtccaaaa ggccctgctg gagagagagg ttcaccaggt     1620

ccagctggtc ctaagggctc ccctggtgaa gcaggtagac caggcgaagc aggattgcca     1680

ggcgcaaagg gattgacagg ctctcctggt agtcctggcc cagatggaaa aacaggccca     1740

ccaggtccag caggacaaga tggacgtcca ggcccaccag gtcctcctgg agcaagggga     1800

caagctggcg ttatgggttt tccaggacct aaaggtgctg ctggagagcc aggaaaggca     1860

ggtgaaagag gagttcctgg tccaccagga gcagtgggtc ctgctggcaa agatggtgaa     1920

gctggagcac agggccctcc aggccctgct ggcccagctg gcgaacgtgg agaacaaggc     1980

ccagctggta gtccaggatt tcaaggattg cctggccctg ctggccctcc aggagaagca     2040

ggaaaacctg gagaacaagg agttcctggt gatttgggag cacctggacc ttcaggagca     2100

cgtggtgaaa gaggcttccc tggcgagagg ggtgttcaag gtccaccagg tccagcagga     2160

cctagaggtg ctaatggcgc tcctggcaac gatggagcaa aaggtgatgc tggtgctcct     2220

ggcgcacctg gaagtcaggg tgctcctgga ttgcaaggaa tgcctggaga gaggggtgct     2280

gctggcttgc caggcccaaa gggcgatagg ggtgatgctg gaccaaaagg tgctgatgga     2340

tccccaggaa aagatggagt tcgtggtctt actggcccaa tcggacctcc aggccctgct     2400

ggcgctccag gtgataaggg cgaaagtggc ccaagtggac ctgctggacc tactggtgct     2460

agaggtgcac ctggtgatag gggtgaacct ggaccacctg gtccagctgg ttttgctggt     2520

cctcctggag ctgatggaca acctggcgca aagggtgaac caggtgatgc tggcgcaaag     2580

ggagatgctg gtccacctgg acctgctggt ccagcaggcc cccctgggcc aatcggtaat     2640

gttggagcac caggtgctaa gggagctagg ggttccgctg gtccacctgg agcaacagga     2700

tttccaggcg ctgctggtag agttggccca ccaggcccat ccggaaacgc aggccctcct     2760

ggtcctccag gtcctgctgg caaggagggt ggcaaaggac caaggggcga aactggccct     2820

gctggtagac ctggcgaagt tggccctcct ggaccaccag gtccagcagg agaaaaaggt     2880

tccccaggag ctgatggccc agctggtgct ccaggaactc caggccctca aggtattgct     2940

ggacagagag gcgttgtggg actccctggt caaaggggag agagaggatt tccaggcttg     3000

ccaggaccta gtggagaacc tggaaaacaa ggcccatcag gcgctagtgg agagcgtgga     3060

cctcctggcc ctatgggacc tcctggattg gctggcccac ctggcgaatc aggtcgtgaa     3120

ggcgcaccag gcgcagaagg atcacctgga agagatggat cccctggtgc taaaggcgat     3180

cgtggagaaa ctggtccagc aggcccacca ggcgcaccag gtgcacctgg cgctccagga     3240

cctgtgggac cagctggaaa atccggagat aggggcgaga caggcccagc aggaccagct     3300

ggacctgttg gccctgctgg cgctcgtgga ccagcaggac ctcaaggacc aaggggagat     3360

aagggagaaa caggcgaaca aggcgatagg ggcattaagg gtcatagggg ttttagtggc     3420

ctccagggtc ctcctggccc acctggatca ccaggagaac agggaccatc tggtgcttcc     3480

ggcccagctg gtccaagagg acctccagga tcagctggtg cacctggaaa agatggtctt     3540

aacggtctcc caggaccaat cggccctcca ggacctagag gaagaacagg agatgctggc     3600

cctgttggcc ctccaggacc tcctggtcca ccaggtccac ctggtcctcc atcagctgga     3660

ttcgattttt catttcttcc acagccacca caagagaaag ctcacgatgg cggcagatat     3720

taccgtgctg atgatgctaa cgttgttagg gatagagatt tggaagtgga tacaactttg     3780

aaatccctct cccagcaaat tgaaaacatt agatctccag aaggttcacg taaaaaccca     3840

gctagaacat gtcgtgattt gaaaatgtgt cactccgatt ggaaaagtgg tgaatactgg     3900

attgatccaa atcagggctg taatctcgat gctatcaaag ttttctgtaa catggaaaca     3960

ggcgaaacat gcgtttatcc tactcaacct tccgtggctc agaaaaattg gtacatctca     4020

aaaaatccta aagataagag gcacgtttgg ttcggtgaaa gtatgactga tggatttcaa     4080

tttgagtacg gcggtcaagg tagtgatcca gctgatgtgg ctattcaact cacatttttg     4140

cgtcttatgt ccacagaggc atcacaaaac atcacttacc actgcaaaaa cagtgtggct     4200

tatatggatc aacaaacagg aaaccttaag aaggctcttc ttttgaaggg ctcaaacgag     4260

attgagatta gagcagaggg caactcaagg tttacttatt cagttactgt tgatggctgc     4320

acttcacata ctggcgcttg gggtaaaaca gttatcgagt ataagactac aaaaacatca     4380

agactcccaa tcattgatgt tgctcctctc gatgttggcg ctcctgatca agagttcggt     4440

tttgatgtgg gcccagtttg tttcctc                                         4467


<210>  10
<211>  4167
<212>  DNA
<213>  Homo sapiens

<400>  10
atggctcacg ctcgtgttct cctcctcgct ctcgctgttt tggcaacagc tgctgtggct       60

gtggcttcaa gttctagttt tgctgattcc aacccaattc gtccagttac tgatagagca      120

gcttccactt tggctcaatt gcttcaagaa gaaactgtga ggaagggccc tgctggcgat      180

aggggcccta ggggcgaaag gggtccacca ggacctccag gcagggatgg cgaagatggt      240

ccaactggcc ctcctggacc tcctggccct ccagggccac ccggcttggg cggaaacttc      300

gcagctcaat acgatggcaa gggtgttggt cttggtcctg gtcctatggg cttgatggga      360

cctagaggcc cacctggtgc tgctggtgct cctggaccac agggttttca gggaccagct      420

ggcgagccag gagagccagg ccaaacagga ccagctggtg caaggggacc tgctggacct      480

cctggaaaag ctggtgaaga tggtcaccca ggcaaaccag gacgtcctgg cgaaagaggt      540

gttgttggac cacaaggcgc taggggattt ccaggtacac ctggattgcc aggttttaag      600

ggcattcgtg gtcataacgg cctcgatgga ttgaagggac agcctggcgc acctggcgtt      660

aagggtgaac ctggagcacc aggtgaaaac ggtactcctg gccagactgg tgcaagagga      720

ctcccaggtg aaaggggtag agttggtgct cctggacctg ctggagctag gggtagtgat      780

ggtagtgttg gtcctgtggg ccctgctggt ccaatcggtt ccgctggccc acctggattc      840

ccaggcgctc caggacctaa aggagaaatc ggtgctgtgg gtaacgcagg tcctactggt      900

ccagcaggtc ctcgtggaga agtgggattg ccaggacttt ctggtccagt gggccctcca      960

ggcaaccctg gagctaacgg cttgacagga gctaaaggcg cagcaggact ccctggagtg     1020

gctggcgcac caggattgcc tggtccaagg ggtatcccag gccctgttgg cgcagctgga     1080

gctactggtg cacgtggact tgttggcgaa ccaggccctg ctggatcaaa aggcgagtct     1140

ggaaataagg gagaacctgg ttctgctgga cctcaaggtc ctcctggacc ttctggagaa     1200

gaaggaaaaa ggggaccaaa tggcgaggct ggatcagcag gtccaccagg accacctgga     1260

cttcgtggat cccctggtag tagaggactt ccaggcgctg atggtagagc aggcgttatg     1320

ggaccaccag gaagtagagg agcatccggt ccagcaggag ttaggggtcc taacggagat     1380

gctggtagac caggtgaacc aggtcttatg ggcccaaggg gcctcccagg tagtccagga     1440

aatatcggcc ctgctggaaa agaaggccct gttggacttc caggtattga tggacgtcct     1500

ggccctattg gcccagcagg tgcaagagga gaacctggca atattggatt tccaggacca     1560

aagggtccaa caggcgatcc tggaaaaaat ggagataagg gtcatgctgg attggcaggc     1620

gcaaggggcg ctcctggtcc agatggaaac aacggcgcac agggtccacc tggccctcag     1680

ggtgttcaag gcggaaaagg cgaacaaggc ccagctggac caccaggctt tcaaggcttg     1740

ccaggaccaa gtggtccagc aggtgaagtt ggcaagccag gcgagcgtgg acttcatggc     1800

gagtttggac tccctggacc agcaggacca aggggtgaaa gaggccctcc tggagagagt     1860

ggcgctgctg gaccaacagg cccaatcggt agtagaggtc ctagtggacc tccaggccca     1920

gatggaaata agggtgaacc aggagttgtg ggcgctgttg gaacagctgg tccttcagga     1980

ccatcaggac tcccaggcga gagaggcgct gctggcattc ctggaggaaa aggtgaaaaa     2040

ggcgaacctg gcctccgtgg cgaaatcgga aatcctggac gtgatggtgc tcgtggtgca     2100

cacggcgctg tgggcgctcc aggccctgct ggtgctactg gtgatagagg agaggctggc     2160

gcagctggcc cagcaggtcc tgctggccca aggggtagtc ctggtgaaag aggcgaagtt     2220

ggacctgctg gccctaacgg ctttgctggc cctgctggag cagcaggtca acctggcgct     2280

aaaggtgaaa ggggcggaaa gggcccaaaa ggtgaaaatg gcgttgtggg accaactggt     2340

ccagtgggcg cagctggacc tgctggtcca aatggaccac caggaccagc aggtagtaga     2400

ggagatggtg gacctccagg aatgacaggt tttccaggtg ctgctggtag aacaggacct     2460

cctggtccta gtggtatttc tggtccacca ggaccaccag gtcctgctgg aaaagaagga     2520

ttgaggggtc cacgtggtga tcaaggacca gtgggcagaa ctggtgaagt tggcgcagtg     2580

ggaccacctg gttttgctgg agaaaagggc ccttctggag aggcaggaac agctggtcct     2640

cctggtacac ctggacctca aggacttttg ggtgcacctg gtattctcgg attgccagga     2700

agtaggggcg aacgtggact tcctggcgtg gcaggagcag ttggagaacc tggccctctc     2760

ggaatcgcag gcccaccagg cgcaagagga ccaccaggag ctgttggatc accaggcgtg     2820

aatggtgcac ctggcgaggc tggtcgtgat ggaaacccag gaaatgatgg cccaccagga     2880

agagatggtc aacctggaca caaaggcgag aggggctacc caggaaatat tggcccagtt     2940

ggtgctgctg gcgcaccagg cccacacggt ccagttggac cagcaggaaa acacggtaat     3000

cgtggcgaaa caggcccttc aggcccagtg ggacctgctg gtgctgttgg cccaagagga     3060

ccatctggac ctcaaggcat tagaggcgat aagggagagc ctggcgaaaa aggacctaga     3120

ggcttgcctg gttttaaagg acacaacggt ctccaaggac ttccaggtat cgctggtcat     3180

catggagatc agggtgctcc tggatcagtg ggtccagcag gtcctagagg cccagcaggc     3240

ccttccggtc cagcaggaaa ggatggacgt actggccacc ctggaactgt gggccctgct     3300

ggaattagag gtcctcaagg tcatcagggc cctgctggcc ctccaggtcc accaggtcct     3360

ccaggcccac caggagtttc aggtggtggt tacgattttg gttacgatgg tgatttttac     3420

cgtgctgatc aacctagaag tgctccttct ctccgtccta aagattatga agttgatgct     3480

actttgaaat cacttaacaa ccagattgag actcttctca cacctgaggg atcaagaaag     3540

aatccagcac gtacatgccg tgatctcaga cttagtcacc cagagtggtc aagtggctat     3600

tattggattg atcctaatca gggttgtaca atggaggcta tcaaagttta ctgtgatttt     3660

ccaactggag agacatgtat tagggcacaa cctgagaaca ttccagctaa aaattggtat     3720

cgttcctcta aagataagaa acatgtttgg ctcggagaga ctattaacgc tggttctcag     3780

ttcgagtata atgttgaggg cgttacttct aaagagatgg caactcagct cgcttttatg     3840

agattgctcg ctaactacgc atcccaaaac atcacttatc actgcaaaaa ttccattgca     3900

tatatggatg aggagacagg aaatttgaag aaagcagtta ttctccaagg tagtaacgat     3960

gttgagcttg tggctgaggg aaatagtaga ttcacttaca cagttttggt ggatggatgc     4020

tcaaagaaaa ctaatgagtg gggcaagaca atcattgagt acaagacaaa taagccttct     4080

aggctcccat ttctcgatat tgcacctctt gatatcggag gagctgatca cgagtttttt     4140

gttgatatcg gacctgtttg ttttaag                                         4167


<210>  11
<211>  1633
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence containing the coding regions of the vascular 
       signal sequence of barley gene for Thiol protease aleurain 
       precursor fused to the human Prolyl 4-hydroxylase beta subunit 
       and flanking regions

<400>  11
ctcgagtaaa ccatggctca tgctagggtt ttgcttttgg ctcttgctgt tcttgctact       60

gctgctgttg ctgtggcttc ttcttcatct ttcgctgatt ctaacccaat taggccagtg      120

actgatagag ctgcttctac tcttgctcaa ttggtcgaca tggatgctcc agaagaggag      180

gatcacgttc ttgtgcttag gaagtctaac ttcgctgaag ctcttgctgc tcacaagtac      240

cttcttgtgg agttttatgc tccttggtgc ggacattgca aagctcttgc tccagagtat      300

gctaaggctg ctggaaagtt gaaggctgag ggatctgaaa ttaggcttgc taaagtggat      360

gctactgagg agtctgatct tgctcaacag tacggagtta ggggataccc aactattaag      420

ttcttcagga acggagatac tgcttctcca aaggagtata ctgctggaag ggaggctgat      480

gatattgtga actggcttaa gaagagaact ggaccagctg ctactactct tccagatgga      540

gctgctgctg aatctcttgt ggagtcatct gaggtggcag tgattggatt cttcaaggat      600

gtggagtctg attctgctaa gcagttcctt caagctgctg aggctattga tgatattcca      660

ttcggaatta cttctaactc tgatgtgttc tctaagtacc agcttgataa ggatggagtg      720

gtgcttttca agaaattcga tgagggaagg aacaatttcg agggagaggt gacaaaggag      780

aaccttcttg atttcattaa gcacaaccag cttccacttg tgattgagtt cactgagcag      840

actgctccaa agattttcgg aggagagatt aagactcaca ttcttctttt ccttccaaag      900

tctgtgtctg attacgatgg aaagttgtct aacttcaaga ctgctgctga gtctttcaag      960

ggaaagattc ttttcatttt cattgattct gatcacactg ataaccagag gattcttgag     1020

ttcttcggac ttaagaagga agagtgccca gctgttaggc ttattactct tgaggaggag     1080

atgactaagt acaagccaga gtctgaagaa cttactgctg agaggattac tgagttctgc     1140

cacagattcc ttgagggaaa gattaagcca caccttatgt ctcaagagct tccagaggat     1200

tgggataagc agccagttaa ggtgttggtg ggtaaaaact tcgaggatgt ggctttcgat     1260

gagaagaaga acgtgttcgt ggagttctac gcaccttggt gtggtcactg taagcagctt     1320

gctccaattt gggataagtt gggagagact tacaaggatc acgagaacat tgtgattgct     1380

aagatggatt ctactgctaa cgaggtggag gctgttaagg ttcactcttt cccaactttg     1440

aagttcttcc cagcttctgc tgataggact gtgattgatt acaacggaga aaggactctt     1500

gatggattca agaagttcct tgagtctgga ggacaagatg gagctggaga tgatgatgat     1560

cttgaggatt tggaagaagc tgaggagcca gatatggagg aggatgatga tcagaaggct     1620

gtgtgatgag ctc                                                        1633


<210>  12
<211>  1723
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence containing the coding regions of the vascular 
       signal sequence of barley gene for Thiol protease aleurain 
       precursor fused to the human Prolyl 4-hydroxylase alpha-1 subunit
       and flanking regions

<400>  12
ctcgagtaaa ccatggctca tgctagggtt ttgcttttgg ctcttgctgt tcttgctact       60

gctgctgttg ctgtggcttc ttcttcatct ttcgctgatt ctaacccaat taggccagtg      120

actgatagag ctgcttctac tcttgctcaa ttggtcgaca tgcacccagg attcttcact      180

tctattggac agatgactga tcttattcac actgagaagg atcttgtgac ttctcttaag      240

gattacatta aggctgagga ggataagttg gagcagatta agaagtgggc tgagaagttg      300

gataggctta cttctactgc tacaaaagat ccagagggat tcgttggtca tccagtgaac      360

gctttcaagt tgatgaagag gcttaacact gagtggagtg agcttgagaa ccttgtgctt      420

aaggatatgt ctgatggatt catttctaac cttactattc agaggcagta cttcccaaat      480

gatgaggatc aagtgggagc tgctaaggct cttcttaggc ttcaggatac ttacaacctt      540

gatactgata caatttctaa gggaaacctt ccaggagtta agcacaagtc tttccttact      600

gctgaggatt gcttcgagct tggaaaggtt gcatacactg aggctgatta ctaccacact      660

gagctttgga tggaacaagc tcttaggcaa cttgatgagg gagagatttc tactattgat      720

aaggtgtcag tgcttgatta cctttcttac gctgtgtacc agcagggtga tcttgataag      780

gctcttttgc ttactaagaa gttgcttgag cttgatccag aacatcagag ggctaacgga      840

aaccttaagt acttcgagta cattatggct aaggaaaagg atgtgaacaa gtctgcttct      900

gatgatcagt ctgatcaaaa gactactcca aagaagaagg gagtggctgt tgattatctt      960

cctgagaggc agaagtatga gatgttgtgt aggggagagg gtattaagat gactccaagg     1020

aggcagaaga agttgttctg caggtatcac gatggaaaca ggaacccaaa gttcattctt     1080

gctccagcta agcaagaaga tgagtgggat aagccaagga ttattaggtt ccacgatatt     1140

atttctgatg ctgagattga gattgtgaag gatcttgcta agccaagact taggagggct     1200

actatttcta accctattac tggtgatctt gagactgtgc actacaggat ttctaagtct     1260

gcttggcttt ctggatacga gaacccagtg gtgtctagga ttaacatgag gattcaggat     1320

cttactggac ttgatgtgtc tactgctgag gagcttcaag ttgctaacta cggagttgga     1380

ggacaatatg agccacactt cgatttcgct aggaaggatg agccagatgc ttttaaggag     1440

cttggaactg gaaacaggat tgctacttgg cttttctaca tgtctgatgt ttctgctgga     1500

ggagctactg ttttcccaga agtgggagct tctgtttggc caaagaaggg aactgctgtg     1560

ttctggtaca accttttcgc ttctggagag ggagattact ctactaggca tgctgcttgc     1620

ccagttcttg ttggaaacaa gtgggtgtca aacaagtggc ttcatgagag gggacaagag     1680

tttagaaggc catgcactct ttctgagctt gagtgatgag ctc                       1723


<210>  13
<211>  2888
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence containing the coding regions of the vascular 
       signal sequence of barley gene for Thiol protease aleurain 
       precursor fused to the human Lysyl hydroxylase 3 and flanking 
       regions

<400>  13
gcgaattcgc tagctatcac tgaaaagaca gcaagacaat ggtgtctcga tgcaccagaa       60

ccacatcttt gcagcagatg tgaagcagcc agagtggtcc acaagacgca ctcagaaaag      120

gcatcttcta ccgacacaga aaaagacaac cacagctcat catccaacat gtagactgtc      180

gttatgcgtc ggctgaagat aagactgacc ccaggccagc actaaagaag aaataatgca      240

agtggtccta gctccacttt agctttaata attatgtttc attattattc tctgcttttg      300

ctctctatat aaagagcttg tattttcatt tgaaggcaga ggcgaacaca cacacagaac      360

ctccctgctt acaaaccaga tcttaaacca tggctcacgc tagggttttg cttcttgctc      420

ttgctgttct tgctactgct gctgttgctg tggcttcttc aagttctttc gctgattcta      480

acccaattag gccagtgact gatagagctg cttctactct tgctcaattg agatctatgt      540

ctgatagacc aaggggaagg gatccagtta atccagagaa gttgcttgtg attactgtgg      600

ctactgctga gactgaagga taccttagat tccttaggag tgctgagttc ttcaactaca      660

ctgtgaggac tcttggactt ggagaagaat ggaggggagg agatgttgct agaactgttg      720

gaggaggaca gaaagtgaga tggcttaaga aagagatgga gaagtacgct gatagggagg      780

atatgattat tatgttcgtg gattcttacg atgtgattct tgctggatct ccaactgagc      840

ttttgaagaa attcgttcag tctggatcta ggcttctttt ctctgctgag tctttttgtt      900

ggccagaatg gggacttgct gagcaatatc cagaagtggg aactggaaag agattcctta      960

actctggagg attcattgga ttcgctacta ctattcacca gattgtgagg cagtggaagt     1020

acaaggatga cgatgatgat cagcttttct acactaggct ttaccttgat ccaggactta     1080

gggagaagtt gtctcttaac cttgatcaca agtctaggat tttccagaac cttaacggtg     1140

ctcttgatga ggttgtgctt aagttcgata ggaacagagt gaggattagg aacgtggctt     1200

acgatactct tcctattgtg gtgcatggaa acggaccaac aaaactccag cttaactacc     1260

ttggaaacta cgttccaaac ggatggactc cagaaggagg atgtggattc tgcaatcagg     1320

ataggagaac tcttccagga ggacaaccac caccaagagt tttccttgct gtgttcgttg     1380

aacagccaac tccattcctt ccaagattcc ttcagaggct tcttcttttg gattacccac     1440

cagatagggt gacacttttc cttcacaaca acgaggtttt ccacgagcca cacattgctg     1500

attcttggcc acagcttcag gatcatttct ctgctgtgaa gttggttggt ccagaagaag     1560

ctctttctcc aggagaagct agggatatgg ctatggattt gtgcaggcag gatccagagt     1620

gcgagttcta cttctctctt gatgctgatg ctgtgcttac taaccttcag actcttagga     1680

ttcttattga ggagaacagg aaagtgattg ctccaatgct ttctaggcac ggaaagttgt     1740

ggtctaattt ctggggtgct ctttctcctg atgagtacta cgctagatca gaggactacg     1800

tggagcttgt tcagagaaag agagtgggag tttggaacgt tccttatatt tctcaggctt     1860

acgtgattag gggagatact cttaggatgg agcttccaca gagggatgtt ttctctggat     1920

ctgatactga tccagatatg gctttctgca agtctttcag ggataaggga attttccttc     1980

acctttctaa ccagcatgag ttcggaagat tgcttgctac ttcaagatac gatactgagc     2040

accttcatcc tgatctttgg cagattttcg ataacccagt ggattggaag gagcagtaca     2100

ttcacgagaa ctactctagg gctcttgaag gagaaggaat tgtggagcaa ccatgcccag     2160

atgtttactg gttcccactt ctttctgagc aaatgtgcga tgagcttgtt gctgagatgg     2220

agcattacgg acaatggagt ggaggtagac atgaggattc taggcttgct ggaggatacg     2280

agaacgttcc aactgtggat attcacatga agcaagtggg atacgaggat caatggcttc     2340

agcttcttag gacttatgtg ggaccaatga ctgagtctct tttcccagga taccacacta     2400

aggctagggc tgttatgaac ttcgttgtga ggtatcgtcc agatgagcaa ccatctctta     2460

ggccacacca cgattcttct actttcactc ttaacgtggc tcttaaccac aagggacttg     2520

attatgaggg aggaggatgc cgtttcctta gatacgattg cgtgatttct tcaccaagaa     2580

agggatgggc tcttcttcat ccaggaaggc ttactcatta ccacgaggga cttccaacta     2640

cttggggaac tagatatatt atggtgtctt tcgtggatcc atgactgctt taatgagata     2700

tgcgagacgc ctatgatcgc atgatatttg ctttcaattc tgttgtgcac gttgtaaaaa     2760

acctgagcat gtgtagctca gatccttacc gccggtttcg gttcattcta atgaatatat     2820

cacccgttac tatcgtattt ttatgaataa tattctccgt tcaatttact gattgtccag     2880

aattcgcg                                                              2888


<210>  14
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vacuolar targeting sequence of the thiol protease aleurain 
       precursor (NCBI accession P05167  GI:113603)

<400>  14

Met Ala His Ala Arg Val Leu Leu Leu Ala Leu Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Ala Val Ala Val Ala Ser Ser Ser Ser Phe Ala Asp Ser Asn Pro 
            20                  25                  30          


Ile Arg Pro Val Thr Asp Arg Ala Ala Ser Thr Leu Ala 
        35                  40                  45  


<210>  15
<211>  1469
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala His Ala Arg Val Leu Leu Leu Ala Leu Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Ala Val Ala Val Ala Ser Ser Ser Ser Phe Ala Asp Ser Asn Pro 
            20                  25                  30          


Ile Arg Pro Val Thr Asp Arg Ala Ala Ser Thr Leu Ala Gln Leu Gln 
        35                  40                  45              


Glu Glu Gly Gln Val Glu Gly Gln Asp Glu Asp Ile Pro Pro Ile Thr 
    50                  55                  60                  


Cys Val Gln Asn Gly Leu Arg Tyr His Asp Arg Asp Val Trp Lys Pro 
65                  70                  75                  80  


Glu Pro Cys Arg Ile Cys Val Cys Asp Asn Gly Lys Val Leu Cys Asp 
                85                  90                  95      


Asp Val Ile Cys Asp Glu Thr Lys Asn Cys Pro Gly Ala Glu Val Pro 
            100                 105                 110         


Glu Gly Glu Cys Cys Pro Val Cys Pro Asp Gly Ser Glu Ser Pro Thr 
        115                 120                 125             


Asp Gln Glu Thr Thr Gly Val Glu Gly Pro Lys Gly Asp Thr Gly Pro 
    130                 135                 140                 


Arg Gly Pro Arg Gly Pro Ala Gly Pro Pro Gly Arg Asp Gly Ile Pro 
145                 150                 155                 160 


Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
                165                 170                 175     


Pro Pro Gly Leu Gly Gly Asn Phe Ala Pro Gln Leu Ser Tyr Gly Tyr 
            180                 185                 190         


Asp Glu Lys Ser Thr Gly Gly Ile Ser Val Pro Gly Pro Met Gly Pro 
        195                 200                 205             


Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Pro Gln 
    210                 215                 220                 


Gly Phe Gln Gly Pro Pro Gly Glu Pro Gly Glu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Pro Met Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Asn Gly Asp 
                245                 250                 255     


Asp Gly Glu Ala Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Pro Pro 
            260                 265                 270         


Gly Pro Gln Gly Ala Arg Gly Leu Pro Gly Thr Ala Gly Leu Pro Gly 
        275                 280                 285             


Met Lys Gly His Arg Gly Phe Ser Gly Leu Asp Gly Ala Lys Gly Asp 
    290                 295                 300                 


Ala Gly Pro Ala Gly Pro Lys Gly Glu Pro Gly Ser Pro Gly Glu Asn 
305                 310                 315                 320 


Gly Ala Pro Gly Gln Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly 
                325                 330                 335     


Arg Pro Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Asn Asp Gly Ala 
            340                 345                 350         


Thr Gly Ala Ala Gly Pro Pro Gly Pro Thr Gly Pro Ala Gly Pro Pro 
        355                 360                 365             


Gly Phe Pro Gly Ala Val Gly Ala Lys Gly Glu Ala Gly Pro Gln Gly 
    370                 375                 380                 


Pro Arg Gly Ser Glu Gly Pro Gln Gly Val Arg Gly Glu Pro Gly Pro 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ala Gly Pro Ala Gly Asn Pro Gly Ala Asp 
                405                 410                 415     


Gly Gln Pro Gly Ala Lys Gly Ala Asn Gly Ala Pro Gly Ile Ala Gly 
            420                 425                 430         


Ala Pro Gly Phe Pro Gly Ala Arg Gly Pro Ser Gly Pro Gln Gly Pro 
        435                 440                 445             


Gly Gly Pro Pro Gly Pro Lys Gly Asn Ser Gly Glu Pro Gly Ala Pro 
    450                 455                 460                 


Gly Ser Lys Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Pro Val Gly 
465                 470                 475                 480 


Val Gln Gly Pro Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala 
                485                 490                 495     


Arg Gly Glu Pro Gly Pro Thr Gly Leu Pro Gly Pro Pro Gly Glu Arg 
            500                 505                 510         


Gly Gly Pro Gly Ser Arg Gly Phe Pro Gly Ala Asp Gly Val Ala Gly 
        515                 520                 525             


Pro Lys Gly Pro Ala Gly Glu Arg Gly Ser Pro Gly Pro Ala Gly Pro 
    530                 535                 540                 


Lys Gly Ser Pro Gly Glu Ala Gly Arg Pro Gly Glu Ala Gly Leu Pro 
545                 550                 555                 560 


Gly Ala Lys Gly Leu Thr Gly Ser Pro Gly Ser Pro Gly Pro Asp Gly 
                565                 570                 575     


Lys Thr Gly Pro Pro Gly Pro Ala Gly Gln Asp Gly Arg Pro Gly Pro 
            580                 585                 590         


Pro Gly Pro Pro Gly Ala Arg Gly Gln Ala Gly Val Met Gly Phe Pro 
        595                 600                 605             


Gly Pro Lys Gly Ala Ala Gly Glu Pro Gly Lys Ala Gly Glu Arg Gly 
    610                 615                 620                 


Val Pro Gly Pro Pro Gly Ala Val Gly Pro Ala Gly Lys Asp Gly Glu 
625                 630                 635                 640 


Ala Gly Ala Gln Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg 
                645                 650                 655     


Gly Glu Gln Gly Pro Ala Gly Ser Pro Gly Phe Gln Gly Leu Pro Gly 
            660                 665                 670         


Pro Ala Gly Pro Pro Gly Glu Ala Gly Lys Pro Gly Glu Gln Gly Val 
        675                 680                 685             


Pro Gly Asp Leu Gly Ala Pro Gly Pro Ser Gly Ala Arg Gly Glu Arg 
    690                 695                 700                 


Gly Phe Pro Gly Glu Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
705                 710                 715                 720 


Pro Arg Gly Ala Asn Gly Ala Pro Gly Asn Asp Gly Ala Lys Gly Asp 
                725                 730                 735     


Ala Gly Ala Pro Gly Ala Pro Gly Ser Gln Gly Ala Pro Gly Leu Gln 
            740                 745                 750         


Gly Met Pro Gly Glu Arg Gly Ala Ala Gly Leu Pro Gly Pro Lys Gly 
        755                 760                 765             


Asp Arg Gly Asp Ala Gly Pro Lys Gly Ala Asp Gly Ser Pro Gly Lys 
    770                 775                 780                 


Asp Gly Val Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala 
785                 790                 795                 800 


Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro Ser Gly Pro Ala Gly 
                805                 810                 815     


Pro Thr Gly Ala Arg Gly Ala Pro Gly Asp Arg Gly Glu Pro Gly Pro 
            820                 825                 830         


Pro Gly Pro Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro 
        835                 840                 845             


Gly Ala Lys Gly Glu Pro Gly Asp Ala Gly Ala Lys Gly Asp Ala Gly 
    850                 855                 860                 


Pro Pro Gly Pro Ala Gly Pro Ala Gly Pro Pro Gly Pro Ile Gly Asn 
865                 870                 875                 880 


Val Gly Ala Pro Gly Ala Lys Gly Ala Arg Gly Ser Ala Gly Pro Pro 
                885                 890                 895     


Gly Ala Thr Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly 
            900                 905                 910         


Pro Ser Gly Asn Ala Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys 
        915                 920                 925             


Glu Gly Gly Lys Gly Pro Arg Gly Glu Thr Gly Pro Ala Gly Arg Pro 
    930                 935                 940                 


Gly Glu Val Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly 
945                 950                 955                 960 


Gly Gln Arg Gly Val Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly 
                965                 970                 975     


Phe Pro Gly Leu Pro Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro 
            980                 985                 990         


Ser Gly Ala Ser Gly Glu Arg Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
        995                 1000                 1005             


Gly Leu  Ala Gly Pro Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro 
    1010                 1015                 1020             


Gly Ala  Glu Gly Ser Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys 
    1025                 1030                 1035             


Gly Asp  Arg Gly Glu Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro 
    1040                 1045                 1050             


Gly Ala  Pro Gly Ala Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser 
    1055                 1060                 1065             


Gly Asp  Arg Gly Glu Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ala Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg 
    1085                 1090                 1095             


Gly Asp  Lys Gly Glu Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys 
    1100                 1105                 1110             


Gly His  Arg Gly Phe Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro 
    1115                 1120                 1125             


Gly Ser  Pro Gly Glu Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala 
    1130                 1135                 1140             


Gly Pro  Arg Gly Pro Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp 
    1145                 1150                 1155             


Gly Leu  Asn Gly Leu Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg 
    1160                 1165                 1170             


Gly Arg  Thr Gly Asp Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro 
    1175                 1180                 1185             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe 
    1190                 1195                 1200             


Ser Phe  Leu Pro Gln Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly 
    1205                 1210                 1215             


Arg Tyr  Tyr Arg Ala Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp 
    1220                 1225                 1230             


Leu Glu  Val Asp Thr Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu 
    1235                 1240                 1245             


Asn Ile  Arg Ser Pro Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr 
    1250                 1255                 1260             


Cys Arg  Asp Leu Lys Met Cys  His Ser Asp Trp Lys  Ser Gly Glu 
    1265                 1270                 1275             


Tyr Trp  Ile Asp Pro Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys 
    1280                 1285                 1290             


Val Phe  Cys Asn Met Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr 
    1295                 1300                 1305             


Gln Pro  Ser Val Ala Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro 
    1310                 1315                 1320             


Lys Asp  Lys Arg His Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly 
    1325                 1330                 1335             


Phe Gln  Phe Glu Tyr Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val 
    1340                 1345                 1350             


Ala Ile  Gln Leu Thr Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser 
    1355                 1360                 1365             


Gln Asn  Ile Thr Tyr His Cys  Lys Asn Ser Val Ala  Tyr Met Asp 
    1370                 1375                 1380             


Gln Gln  Thr Gly Asn Leu Lys  Lys Ala Leu Leu Leu  Lys Gly Ser 
    1385                 1390                 1395             


Asn Glu  Ile Glu Ile Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr 
    1400                 1405                 1410             


Ser Val  Thr Val Asp Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly 
    1415                 1420                 1425             


Lys Thr  Val Ile Glu Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro 
    1430                 1435                 1440             


Ile Ile  Asp Val Ala Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu 
    1445                 1450                 1455             


Phe Gly  Phe Asp Val Gly Pro  Val Cys Phe Leu 
    1460                 1465                 


<210>  16
<211>  4416
<212>  DNA
<213>  Homo sapiens

<400>  16
atggctcacg ctcgtgttct cctcctcgct ctcgctgttt tggcaacagc tgctgtggct       60

gtggcttcta gttcttcttt tgctgattca aaccctatta gacctgttac tgatagagca      120

gcttccactt tggctcaatt gcaagaggag ggccaggttg agggccaaga tgaggatatc      180

cctccaatta catgcgtgca aaatggcttg cgttaccacg atagggatgt gtggaaacct      240

gaaccttgtc gtatctgtgt gtgtgataac ggcaaggtgc tctgcgatga tgttatctgc      300

gatgagacaa aaaattgccc tggcgctgaa gttcctgagg gcgagtgttg ccctgtgtgc      360

cctgatggtt ccgagtcccc aactgatcag gaaactactg gcgtggaggg cccaaaagga      420

gatactggtc cacgtggtcc taggggtcca gcaggtcctc caggtagaga tggtattcca      480

ggccagcctg gattgccagg accaccaggc ccacctggcc caccaggacc tcctggtctt      540

ggtggaaatt tcgctccaca actctcttat ggctatgatg agaagtcaac aggtggtatt      600

tccgttccag gtcctatggg accatccgga ccaagaggtc tcccaggtcc tccaggtgct      660

cctggacctc aaggctttca aggacctcca ggcgaaccag gagaaccagg cgcttctgga      720

ccaatgggcc caaggggacc acctggccca ccaggaaaaa atggcgatga tggcgaagct      780

ggaaagcctg gtcgtcctgg agagagaggt cctcctggcc cacagggtgc aagaggcttg      840

ccaggaactg ctggcttgcc tggaatgaag ggacataggg gcttctccgg cctcgatggc      900

gctaagggtg atgctggccc tgctggacca aagggcgagc caggttcccc tggagaaaac      960

ggtgctcctg gacaaatggg tcctcgtgga cttccaggag aaaggggtcg tccaggcgct     1020

ccaggaccag caggtgctag gggaaacgat ggtgcaacag gcgctgctgg ccctcctggc     1080

ccaactggtc ctgctggccc tccaggattc ccaggcgcag ttggagctaa aggagaagca     1140

ggaccacagg gccctagggg ttctgaagga cctcagggtg ttagaggtga accaggtcct     1200

ccaggcccag ctggagcagc tggtccagca ggaaatccag gtgctgatgg tcaacctgga     1260

gctaagggcg ctaatggcgc accaggtatc gcaggcgcac caggttttcc tggcgctaga     1320

ggcccaagtg gtcctcaagg accaggtgga ccaccaggtc caaaaggcaa ttctggcgaa     1380

cctggcgctc caggttctaa aggagatact ggtgctaaag gcgaaccagg acctgttggt     1440

gttcagggtc ctcctggtcc tgctggagaa gaaggaaaaa gaggtgctcg tggagaacca     1500

ggaccaactg gacttcctgg acctcctggt gaacgtggcg gacctggctc aaggggtttc     1560

cctggagctg atggagtggc aggtccaaaa ggccctgctg gagagagagg ttcaccaggt     1620

ccagctggtc ctaagggctc ccctggtgaa gcaggtagac caggcgaagc aggattgcca     1680

ggcgcaaagg gattgacagg ctctcctggt agtcctggcc cagatggaaa aacaggccca     1740

ccaggtccag caggacaaga tggacgtcca ggcccaccag gtcctcctgg agcaagggga     1800

caagctggcg ttatgggttt tccaggacct aaaggtgctg ctggagagcc aggaaaggca     1860

ggtgaaagag gagttcctgg tccaccagga gcagtgggtc ctgctggcaa agatggtgaa     1920

gctggagcac agggccctcc aggccctgct ggcccagctg gcgaacgtgg agaacaaggc     1980

ccagctggta gtccaggatt tcaaggattg cctggccctg ctggccctcc aggagaagca     2040

ggaaaacctg gagaacaagg agttcctggt gatttgggag cacctggacc ttcaggagca     2100

cgtggtgaaa gaggcttccc tggcgagagg ggtgttcaag gtccaccagg tccagcagga     2160

cctagaggtg ctaatggcgc tcctggcaac gatggagcaa aaggtgatgc tggtgctcct     2220

ggcgcacctg gaagtcaggg tgctcctgga ttgcaaggaa tgcctggaga gaggggtgct     2280

gctggcttgc caggcccaaa gggcgatagg ggtgatgctg gaccaaaagg tgctgatgga     2340

tccccaggaa aagatggagt tcgtggtctt actggcccaa tcggacctcc aggccctgct     2400

ggcgctccag gtgataaggg cgaaagtggc ccaagtggac ctgctggacc tactggtgct     2460

agaggtgcac ctggtgatag gggtgaacct ggaccacctg gtccagctgg ttttgctggt     2520

cctcctggag ctgatggaca acctggcgca aagggtgaac caggtgatgc tggcgcaaag     2580

ggagatgctg gtccacctgg acctgctggt ccagcaggcc cccctgggcc aatcggtaat     2640

gttggagcac caggtgctaa gggagctagg ggttccgctg gtccacctgg agcaacagga     2700

tttccaggcg ctgctggtag agttggccca ccaggcccat ccggaaacgc aggccctcct     2760

ggtcctccag gtcctgctgg caaggagggt ggcaaaggac caaggggcga aactggccct     2820

gctggtagac ctggcgaagt tggccctcct ggaccaccag gtccagcagg agaaaaaggt     2880

ggacagagag gcgttgtggg actccctggt caaaggggag agagaggatt tccaggcttg     2940

ccaggaccta gtggagaacc tggaaaacaa ggcccatcag gcgctagtgg agagcgtgga     3000

cctcctggcc ctatgggacc tcctggattg gctggcccac ctggcgaatc aggtcgtgaa     3060

ggcgcaccag gcgcagaagg atcacctgga agagatggat cccctggtgc taaaggcgat     3120

cgtggagaaa ctggtccagc aggcccacca ggcgcaccag gtgcacctgg cgctccagga     3180

cctgtgggac cagctggaaa atccggagat aggggcgaga caggcccagc aggaccagct     3240

ggacctgttg gccctgctgg cgctcgtgga ccagcaggac ctcaaggacc aaggggagat     3300

aagggagaaa caggcgaaca aggcgatagg ggcattaagg gtcatagggg ttttagtggc     3360

ctccagggtc ctcctggccc acctggatca ccaggagaac agggaccatc tggtgcttcc     3420

ggcccagctg gtccaagagg acctccagga tcagctggtg cacctggaaa agatggtctt     3480

aacggtctcc caggaccaat cggccctcca ggacctagag gaagaacagg agatgctggc     3540

cctgttggcc ctccaggacc tcctggtcca ccaggtccac ctggtcctcc atcagctgga     3600

ttcgattttt catttcttcc acagccacca caagagaaag ctcacgatgg cggcagatat     3660

taccgtgctg atgatgctaa cgttgttagg gatagagatt tggaagtgga tacaactttg     3720

aaatccctct cccagcaaat tgaaaacatt agatctccag aaggttcacg taaaaaccca     3780

gctagaacat gtcgtgattt gaaaatgtgt cactccgatt ggaaaagtgg tgaatactgg     3840

attgatccaa atcagggctg taatctcgat gctatcaaag ttttctgtaa catggaaaca     3900

ggcgaaacat gcgtttatcc tactcaacct tccgtggctc agaaaaattg gtacatctca     3960

aaaaatccta aagataagag gcacgtttgg ttcggtgaaa gtatgactga tggatttcaa     4020

tttgagtacg gcggtcaagg tagtgatcca gctgatgtgg ctattcaact cacatttttg     4080

cgtcttatgt ccacagaggc atcacaaaac atcacttacc actgcaaaaa cagtgtggct     4140

tatatggatc aacaaacagg aaaccttaag aaggctcttc ttttgaaggg ctcaaacgag     4200

attgagatta gagcagaggg caactcaagg tttacttatt cagttactgt tgatggctgc     4260

acttcacata ctggcgcttg gggtaaaaca gttatcgagt ataagactac aaaaacatca     4320

agactcccaa tcattgatgt tgctcctctc gatgttggcg ctcctgatca agagttcggt     4380

tttgatgtgg gcccagtttg tttcctctaa tgagct                               4416


