                         SEQUENCE LISTING

<110>  Dingfu Biotarget Co., Ltd.
 
<120>  PROTEINACEOUS HETERODIMER AND USE THEREOF

<130>  0027-PA-015

<160>  180   

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Y349C+T366W

<400>  1

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  2
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B D356C+T366S+L368A+Y407V

<400>  2

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  3
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B D356C+T366S+L368A+Y407V+F405K

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Y349C+T366W+F405K

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  5
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Y349C+T366W+K409E

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  6
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Y349C+T366W+K409A

<400>  6

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  7
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Y349C+T366W+F405K+K360E+Q347E

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  8
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B D356C+T366S+L368A+Y407V+Q347R

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Arg Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  9
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Y349C+T366W+F405K+Q347R

<400>  9

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Arg Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  10
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B D356C+T366S+L368A+Y407V+K360E+Q347E

<400>  10

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Glu Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  11
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Y349C+T366W+K409A+K360E+Q347E

<400>  11

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  12
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B D356C+T366S+L368A+Y407V+F405K+Q347R

<400>  12

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Arg Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  13
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Y349C+T366W+K409A+Q347R

<400>  13

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Arg Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  14
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B D356C+T366S+L368A+Y407V+F405K+K360E+Q347E

<400>  14

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Glu Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  15
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366W+K409A+K392D

<400>  15

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  16
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B T366S+L368A+Y407V+D399S+F405K

<400>  16

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Ser Ser Asp Gly Ser Phe Lys Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  17
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366W+K409A

<400>  17

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  18
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B T366S+L368G+Y407A+F405K

<400>  18

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Ala Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  19
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366W+K409A+Y349D

<400>  19

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Asp Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  20
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B T366S+L368A+Y407V+F405K+E357A

<400>  20

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Ala Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  21
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366W+K409A+Y349D+S354D

<400>  21

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Asp Thr Leu Pro Pro Asp Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  22
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366W+F405K

<400>  22

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  23
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B T366S+L368A+Y407V+K409A

<400>  23

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  24
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366W+F405K+D399S

<400>  24

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Ser Ser Asp Gly Ser Phe Lys Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  25
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B T366S+L368A+Y407V+K409A+K392D

<400>  25

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  26
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366S+L368G+Y407A+K409A

<400>  26

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Ala Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  27
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366W +F405K +Y349D

<400>  27

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Asp Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  28
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B T366S+L368A+Y407V +K409A +E357A

<400>  28

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Ala Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  29
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A T366W+F405K+Y349D+S354D

<400>  29

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Asp Thr Leu Pro Pro Asp Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  30
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  31
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  31
gacaagaccc acacctgccc cccctgcccc gcccccgagc tgctgggcgg ccccagcgtg       60

ttcctgttcc cccccaagcc caaggacacc ctgatgatca gccgcacccc cgaggtgacc      120

tgcgtggtgg tggacgtgag ccacgagaac cccgaggtga agttcaactg gtacgtggac      180

ggcgtggagg tgcacaacgc caagaccaag ccccgcgagg agcagtacaa cagcacctac      240

cgcgtggtga gcgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtacaag      300

tgcaaggtga gcaacaaggc cctgcccgcc cccatcgaga agaccatcag caaggccaag      360

ggccagcccc gcgagcccca ggtgtacacc ctgcccccca gccgcgacga gctgaccaag      420

aaccaggtga gcctgacctg cctggtgaag ggcttctacc ccagcgacat cgccgtggag      480

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccccgt gctggacagc      540

gacggcagct tcttcctgta cagcaagctg accgtggaca agagccgctg gcagcagggc      600

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc      660

ctgagcctga gccccggcaa g                                                681


<210>  32
<211>  741
<212>  DNA
<213>  Mus musculus

<400>  32
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg cagcaccggc       60

gacaagaccc acacctgccc cccctgcccc gcccccgagc tgctgggcgg ccccagcgtg      120

ttcctgttcc cccccaagcc caaggacacc ctgatgatca gccgcacccc cgaggtgacc      180

tgcgtggtgg tggacgtgag ccacgagaac cccgaggtga agttcaactg gtacgtggac      240

ggcgtggagg tgcacaacgc caagaccaag ccccgcgagg agcagtacaa cagcacctac      300

cgcgtggtga gcgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtacaag      360

tgcaaggtga gcaacaaggc cctgcccgcc cccatcgaga agaccatcag caaggccaag      420

ggccagcccc gcgagcccca ggtgtacacc ctgcccccca gccgcgacga gctgaccaag      480

aaccaggtga gcctgacctg cctggtgaag ggcttctacc ccagcgacat cgccgtggag      540

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccccgt gctggacagc      600

gacggcagct tcttcctgta cagcaagctg accgtggaca agagccgctg gcagcagggc      660

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc      720

ctgagcctga gccccggcaa g                                                741


<210>  33
<211>  1121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion gene fragment

<400>  33
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg cagcaccggc       60

caggtgcagc tgcaggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc      120

tcctgtgcag cctctgaata catctacagt agctactgca tggcctggtt ccgccaggct      180

ccagggaagg agcgcgaggg ggtcgcagtt attgggagtg atggtagcac aagctacgca      240

gactccgtga aaggccgatt caccatctcc aaagacaacg ccaagaacac tctgtatctg      300

caaatgaaca gcctgaaacc tgaggacact gccatgtact actgtgcggc catcggtggt      360

tactgctacc aaccacccta tgagtaccag tactggggcc aggggaccca ggtcaccgtc      420

tcccagaacc gaaaagcagc gacaagaccc acacctgccc cccctgcccc gcccccgagc      480

tgctgggcgg ccccagcgtg ttcctgttcc cccccaagcc caaggacacc ctgatgatca      540

gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgagaac cccgaggtga      600

agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag ccccgcgagg      660

agcagtacaa cagcacctac cgcgtggtga gcgtgctgac cgtgctgcac caggactggc      720

tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgcc cccatcgaga      780

agaccatcag caaggccaag ggccagcccc gcgagcccca ggtgtacacc ctgcccccca      840

gccgcgacga gctgaccaag aaccaggtga gcctgacctg cctggtgaag ggcttctacc      900

ccagcgacat cgccgtggag tgggagagca acggccagcc cgagaacaac tacaagacca      960

ccccccccgt gctggacagc gacggcagct tcttcctgta cagcaagctg accgtggaca     1020

agagccgctg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag gccctgcaca     1080

accactacac ccagaagagc ctgagcctga gccccggcaa g                         1121


<210>  34
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein VhH-Fc

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Ile Tyr Ser Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile Gly Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ile Gly Gly Tyr Cys Tyr Gln Pro Pro Tyr Glu Tyr Gln Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  35
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gene for anti-Her2 single chain ScFv-Fc fusion protein

<400>  35
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg cagcaccggc       60

gaggtgcagc tgctggagag cggcggcggc gtggtgcagc ccggccgcag cctgcgcctg      120

agctgcatcg ccagcggctt caccttcagc agctacccca tgacctgggt gcgccaggcc      180

cccggcaagg gcctggagtg ggtggccagc atcagctacg acggcagcta caagtacaag      240

gccgacagca tgaagggccg cctgaccatc agccgcgaca acagcaagaa caccctgtac      300

ctggagatga acagcctgac cgccgaggac accgccgtgt actactgcgc ccgcaccgcc      360

ttcttcaacg cctacgactt ctggggccag ggcaccctgg tgaccgtgag cagcgccagc      420

accaagggcc ccagcgtggg cggcggcggc agcggcggcg gcggcagcga gatcgtgatg      480

acccagagcc ccgccaccct gagcgtgagc cccggcgagc gcgccaccct gagctgccgc      540

gccagccaga gcgtgcgcag caacctggcc tggtaccagc agaagcccgg ccaggccccc      600

cgcctgctga tctacgccgc cagcacccgc gccaccggca tccccgcccg cttcagcggc      660

agcggcagcg gcaccgagtt caccctgacc atcagcagcc tgcagagcga ggacttcgcc      720

gtgtactact gccagcagta caacgagtgg ttccgcacca gcggccaggg caccaaggtg      780

gagatcaagc gcgacaagac ccacacctgc cccccctgcc ccgcccccga gctgctgggc      840

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccgcacc      900

cccgaggtga cctgcgtggt ggtggacgtg agccacgaga accccgaggt gaagttcaac      960

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccgcga ggagcagtac     1020

aacagcacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1080

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg cccccatcga gaagaccatc     1140

agcaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc cagccgcgac     1200

gagctgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1260

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1320

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagagccgc     1380

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1440

acccagaaga gcctgagcct gagccccggc aag                                  1473


<210>  36
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-Her2 single chain ScFv -Fc fusion protein

<400>  36

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Tyr Asp Gly Ser Tyr Lys Tyr Lys Ala Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ala Phe Phe Asn Ala Tyr Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Arg Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Ala Ser Thr Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Glu Trp Phe Arg Thr Ser Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Arg Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asn Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  37
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Erb-LC

<400>  37

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  38
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding Erb-LC

<400>  38
gacatcctgc tgacccagag ccccgtgatc ctgagcgtga gccccggcga gcgcgtgagc       60

ttcagctgcc gcgccagcca gagcatcggc accaacatcc actggtacca gcagcgcacc      120

aacggcagcc cccgcctgct gatcaagtac gccagcgaga gcatcagcgg catccccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga gcatcaacag cgtggagagc      240

gaggacatcg ccgactacta ctgccagcag aacaacaact ggcccaccac cttcggcgcc      300

ggcaccaagc tggagctgaa gcgcaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac cgcggcgagt gc                         642


<210>  39
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  erb-Fc9

<400>  39

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  40
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding erb-Fc9

<400>  40
caggtgcagc tgaagcagag cggccccggc ctggtgcagc ccagccagag cctgagcatc       60

acctgcaccg tgagcggctt cagcctgacc aactacggcg tgcactgggt gcgccagagc      120

cccggcaagg gcctggagtg gctgggcgtg atctggagcg gcggcaacac cgactacaac      180

acccccttca ccagccgcct gagcatcaac aaggacaaca gcaagagcca ggtgttcttc      240

aagatgaaca gcctgcagag caacgacacc gccatctact actgcgcccg cgccctgacc      300

tactacgact acgagttcgc ctactggggc cagggcaccc tggtgaccgt gagcgccgcc      360

agcactaagg ggccctctgt gtttccactc gccccttcta gcaaaagcac ttccggagga      420

actgccgctc tgggctgtct ggtgaaagat tacttccccg aaccagtcac tgtgtcatgg      480

aactctggag cactgacatc tggagttcac acctttcctg ctgtgctgca gagttctgga      540

ctgtactccc tgtcatctgt ggtcaccgtg ccatcttcat ctctggggac ccagacctac      600

atctgtaacg tgaaccacaa accctccaac acaaaagtgg acaaacgagt cgaaccaaaa      660

tcttgtgaca aaacccacac atgcccaccg tgcccagctc cggaactcct gggcggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccaagtcg ggatgagctg     1080

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgttg     1200

gactccgacg gctccttctt cctctacagc gcgctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  41
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Erb-Fc6

<400>  41

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys 
        115                 120                 125             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    130                 135                 140                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
145                 150                 155                 160 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                165                 170                 175     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            180                 185                 190         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        195                 200                 205             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    210                 215                 220                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
225                 230                 235                 240 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                245                 250                 255     


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Gly Val Lys Gly Phe Tyr 
            260                 265                 270         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        275                 280                 285             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Lys 
    290                 295                 300                 


Leu Ala Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
305                 310                 315                 320 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                325                 330                 335     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345     


<210>  42
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding Erb-Fc6

<400>  42
caggtgcagc tgaagcagag cggccccggc ctggtgcagc ccagccagag cctgagcatc       60

acctgcaccg tgagcggctt cagcctgacc aactacggcg tgcactgggt gcgccagagc      120

cccggcaagg gcctggagtg gctgggcgtg atctggagcg gcggcaacac cgactacaac      180

acccccttca ccagccgcct gagcatcaac aaggacaaca gcaagagcca ggtgttcttc      240

aagatgaaca gcctgcagag caacgacacc gccatctact actgcgcccg cgccctgacc      300

tactacgact acgagttcgc ctactggggc cagggcaccc tggtgaccgt gagcgccgac      360

aagacccaca cttgcccccc ttgtcccgct ccggaactcc tgggcggacc gtcagtcttc      420

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      480

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      540

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      600

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      660

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      720

cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac      780

caggtcagcc tgagttgcgg ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg      840

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac      900

ggctccttca agctcgccag caagctcacc gtggacaaga gcaggtggca gcaggggaac      960

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1020

tccctgtctc cgggtaaa                                                   1038



<210>  43
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Erb-Knob

<400>  43

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  44
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding Erb-Knob

<400>  44
caggtgcagc tgaagcagag cggccccggc ctggtgcagc ccagccagag cctgagcatc       60

acctgcaccg tgagcggctt cagcctgacc aactacggcg tgcactgggt gcgccagagc      120

cccggcaagg gcctggagtg gctgggcgtg atctggagcg gcggcaacac cgactacaac      180

acccccttca ccagccgcct gagcatcaac aaggacaaca gcaagagcca ggtgttcttc      240

aagatgaaca gcctgcagag caacgacacc gccatctact actgcgcccg cgccctgacc      300

tactacgact acgagttcgc ctactggggc cagggcaccc tggtgaccgt gagcgccgcc      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc      420

accgccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgagctgg      480

aacagcggcg ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac      600

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagcgcgt ggagcccaag      660

agctgcgaca agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg cacccccgag      780

gtgacctgcg tggtggtgga cgtgagccac gaggaccccg aggtgaagtt caactggtac      840

gtggacggcg tggaggtgca caacgccaag accaagcccc gcgaggagca gtacaacagc      900

acctaccgcg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtgagcaa caaggccctg cccgccccca tcgagaagac catcagcaag     1020

gccaagggcc agccccgcga gccccaggtg tacaccctgc ccccctgccg cgacgagctg     1080

accaagaacc aggtgagcct gtggtgcctg gtgaagggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccccgtgctg     1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag ccgctggcag     1260

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag     1320

aagagcctga gcctgagccc cggcaag                                         1347


<210>  45
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T-LC

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  46
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding T-LC

<400>  46
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc       60

atcacctgcc gcgccagcca ggacgtgaac accgccgtgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacagc gccagcttcc tgtacagcgg cgtgcccagc      180

cgcttcagcg gcagccgcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag cactacacca ccccccccac cttcggccag      300

ggcaccaagg tggagatcaa atactactgc cagcagaaca acaactggcc caccaccttc      360

ggcgccggca ccaagctgga gctgaagcgc accgtggccg cccccagcgt gttcatcttc      420

ccccccagcg acgagcagct gaagagcggc accgccagcg tggtgtgcct gctgaacaac      480

ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaac      540

agccaggaga gcgtgaccga gcaggacagc aaggacagca cctacagcct gagcagcacc      600

ctgaccctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga ggtgacccac      660

cagggcctga gcagccccgt gaccaagagc ttcaaccgcg gcgagtgc                   708


<210>  47
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T-Fc9

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  48
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding T-Fc9

<400>  48
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgcgcctg       60

agctgcgccg ccagcggctt caacatcaag gacacctaca tccactgggt gcgccaggcc      120

cccggcaagg gcctggagtg ggtggcccgc atctacccca ccaacggcta cacccgctac      180

gccgacagcg tgaagggccg cttcaccatc agcgccgaca ccagcaagaa caccgcctac      240

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcag ccgctggggc      300

ggcgacggct tctacgccat ggactactgg ggccagggca ccctggtgac cgtgagcagc      360

gccagcacta aggggccctc tgtgtttcca ctcgcccctt ctagcaaaag cacttccgga      420

ggaactgccg ctctgggctg tctggtgaaa gattacttcc ccgaaccagt cactgtgtca      480

tggaactctg gagcactgac atctggagtt cacacctttc ctgctgtgct gcagagttct      540

ggactgtact ccctgtcatc tgtggtcacc gtgccatctt catctctggg gacccagacc      600

tacatctgta acgtgaacca caaaccctcc aacacaaaag tggacaaacg agtcgaacca      660

aaatcttgtg acaaaaccca cacatgccca ccgtgcccag ctccggaact cctgggcgga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccaag tcgggatgag     1080

ctgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ttggactccg acggctcctt cttcctctac agcgcgctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  49
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-LC

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  50
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding P-LC

<400>  50
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc       60

atcacctgca aggccagcca ggacgtgagc atcggcgtgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacagc gccagctacc gctacaccgg cgtgcccagc      180

cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tactacatct acccctacac cttcggccag      300

ggcaccaagg tggagatcaa gtactactgc cagcagaaca acaactggcc caccaccttc      360

ggcgccggca ccaagctgga gctgaagcgc accgtggccg cccccagcgt gttcatcttc      420

ccccccagcg acgagcagct gaagagcggc accgccagcg tggtgtgcct gctgaacaac      480

ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaac      540

agccaggaga gcgtgaccga gcaggacagc aaggacagca cctacagcct gagcagcacc      600

ctgaccctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga ggtgacccac      660

cagggcctga gcagccccgt gaccaagagc ttcaaccgcg gcgagtgc                   708


<210>  51
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-Fc9

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  52
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding P-Fc9

<400>  52
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgcgcctg       60

agctgcgccg ccagcggctt caccttcacc gactacacca tggactgggt gcgccaggcc      120

cccggcaagg gcctggagtg ggtggccgac gtgaacccca acagcggcgg cagcatctac      180

aaccagcgct tcaagggccg cttcaccctg agcgtggacc gcagcaagaa caccctgtac      240

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcgc ccgcaacctg      300

ggccccagct tctacttcga ctactggggc cagggcaccc tggtgaccgt gagcagcgcc      360

agcactaagg ggccctctgt gtttccactc gccccttcta gcaaaagcac ttccggagga      420

actgccgctc tgggctgtct ggtgaaagat tacttccccg aaccagtcac tgtgtcatgg      480

aactctggag cactgacatc tggagttcac acctttcctg ctgtgctgca gagttctgga      540

ctgtactccc tgtcatctgt ggtcaccgtg ccatcttcat ctctggggac ccagacctac      600

atctgtaacg tgaaccacaa accctccaac acaaaagtgg acaaacgagt cgaaccaaaa      660

tcttgtgaca aaacccacac atgcccaccg tgcccagctc cggaactcct gggcggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccaagtcg ggatgagctg     1080

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgttg     1200

gactccgacg gctccttctt cctctacagc gcgctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  53
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806-LC

<400>  53

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  54
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding Mab806-LC

<400>  54
gacatcctga tgacccagag ccccagcagc atgagcgtga gcctgggcga caccgtgagc       60

atcacctgcc acagcagcca ggacatcaac agcaacatcg gctggctgca gcagcgcccc      120

ggcaagagct tcaagggcct gatctaccac ggcaccaacc tggacgacga ggtgcccagc      180

cgcttcagcg gcagcggcag cggcgccgac tacagcctga ccatcagcag cctggagagc      240

gaggacttcg ccgactacta ctgcgtgcag tacgcccagt tcccctggac cttcggcggc      300

ggcaccaagc tggagatcaa gtactactgc cagcagaaca acaactggcc caccaccttc      360

ggcgccggca ccaagctgga gctgaagcgc accgtggccg cccccagcgt gttcatcttc      420

ccccccagcg acgagcagct gaagagcggc accgccagcg tggtgtgcct gctgaacaac      480

ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaac      540

agccaggaga gcgtgaccga gcaggacagc aaggacagca cctacagcct gagcagcacc      600

ctgaccctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga ggtgacccac      660

cagggcctga gcagccccgt gaccaagagc ttcaaccgcg gcgagtgc                   708


<210>  55
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806-Fc9

<400>  55

Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  56
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding Mab806-Fc9

<400>  56
gacgtgcagc tgcaggagag cggccccagc ctggtgaagc ccagccagag cctgagcctg       60

acctgcaccg tgaccggcta cagcatcacc agcgacttcg cctggaactg gatccgccag      120

ttccccggca acaagctgga gtggatgggc tacatcagct acagcggcaa cacccgctac      180

aaccccagcc tgaagagccg catcagcatc acccgcgaca ccagcaagaa ccagttcttc      240

ctgcagctga acagcgtgac catcgaggac accgccacct actactgcgt gaccgccggc      300

cgcggcttcc cctactgggg ccagggcacc ctggtgaccg tgagcgccgc cagcactaag      360

gggccctctg tgtttccact cgccccttct agcaaaagca cttccggagg aactgccgct      420

ctgggctgtc tggtgaaaga ttacttcccc gaaccagtca ctgtgtcatg gaactctgga      480

gcactgacat ctggagttca cacctttcct gctgtgctgc agagttctgg actgtactcc      540

ctgtcatctg tggtcaccgt gccatcttca tctctgggga cccagaccta catctgtaac      600

gtgaaccaca aaccctccaa cacaaaagtg gacaaacgag tcgaaccaaa atcttgtgac      660

aaaacccaca catgcccacc gtgcccagct ccggaactcc tgggcggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccaagtc gggatgagct gaccaagaac     1080

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag cgcgctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  57
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB-LC

<400>  57

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Arg Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  58
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding C-MAB-LC

<400>  58
gacgtggtga tgacccagag ccccctgagc ctgcctgtga cacctggcga gcctgccagc       60

atcagctgca gaagcagcca gtccctggtg cacagcaaca ggaacaccta cctgcactgg      120

tatttacaga agcccggaca gagcccccag ctgctgatct acaaggtgag caacaggttc      180

agcggcgtgc ctgacaggtt ttccggcagc ggcagcggca ccgacttcac cctgaagatc      240

agcagggtgg aggccgagga tgtgggcgtg tactactgca gccagaacac ccacgtgccc      300

cctacctttg gccagggcac caagctggag atcaagcgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggta ccgctagcgt tgtgtgcctg      420

ctgaataact tttatccacg ggaggctaag gtgcagtgga aagtggacaa tgccctccag      480

agcggaaata gccaagagtc cgttaccgaa caggactcta aagactctac atactccctg      540

tcctccacac tgaccctctc caaggccgac tatgagaaac acaaggttta cgcatgcgag      600

gtcacacacc agggactctc ctctcccgtg accaagagct tcaaccgggg agaatgc         657


<210>  59
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB-Fc9

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  60
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding C-MAB-Fc9

<400>  60
caggtgcagc tggtgcagag cggcgccgag gtgaagaaac ctggcgccag cgtgaaggtg       60

agctgcaagg cctccggcta caccttcacc gactacgaga tgcactgggt gaggcaggcc      120

cctggacaag gactggagtg gatgggcgcc ttagatccta agacaggcga caccgcctac      180

tcccagaagt tcaagggcag ggtgaccctg accgccgaca agagcaccag caccgcctac      240

atggagctga gcagcctgac cagcgaggac accgccgtgt actattgcac caggttctac      300

agctacacct actggggcca gggcacactg gtgaccgtga gcagcgccag cactaagggg      360

ccctctgtgt ttccactcgc cccttctagc aaaagcactt ccggaggaac tgccgctctg      420

ggctgtctgg tgaaagatta cttccccgaa ccagtcactg tgtcatggaa ctctggagca      480

ctgacatctg gagttcacac ctttcctgct gtgctgcaga gttctggact gtactccctg      540

tcatctgtgg tcaccgtgcc atcttcatct ctggggaccc agacctacat ctgtaacgtg      600

aaccacaaac cctccaacac aaaagtggac aaacgagtcg aaccaaaatc ttgtgacaaa      660

acccacacat gcccaccgtg cccagctccg gaactcctgg gcggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccaagtcggg atgagctgac caagaaccag     1080

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgttgga ctccgacggc     1200

tccttcttcc tctacagcgc gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  61
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1-LC

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  62
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding 28H1-LC

<400>  62
gagatcgtgc tgacacagtc tccaggcacc ctgtctctgt ctccaggaga gagagccacc       60

ctgtcttgca gagcctctca gagcgtgtcc aggagctacc tggcttggta tcagcagaag      120

ccaggacagg cccctagact gctgatcatc ggagcctcta caagagccac aggcatccca      180

gacagattca gcggcagcgg aagcggcaca gacttcaccc tgaccatcag caggctggag      240

ccagaggact tcgccgtgta ctattgccag cagggccagg tcatccctcc tacctttgga      300

cagggcacca aggtggagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggtacc gctagcgttg tgtgcctgct gaataacttt      420

tatccacggg aggctaaggt gcagtggaaa gtggacaatg ccctccagag cggaaatagc      480

caagagtccg ttaccgaaca ggactctaaa gactctacat actccctgtc ctccacactg      540

accctctcca aggccgacta tgagaaacac aaggtttacg catgcgaggt cacacaccag      600

ggactctcct ctcccgtgac caagagcttc aaccggggag aatgc                      645


<210>  63
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1-Fc9

<400>  63

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  64
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding 28H1-Fc9

<400>  64
gaggtgcagc tgctggaatc aggaggagga ctggtgcagc caggaggatc tctgagactg       60

tcttgcgccg ccagcggctt tacattcagc tctcacgcca tgtcttgggt ccgacaggct      120

ccaggcaaag gactggaatg ggtgtccgct atttgggcca gcggagagca gtactacgcc      180

gacagcgtga agggacggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagggc ccaggatacc gccgtgtact attgcgccaa gggttggctg      300

ggcaacttcg actattgggg ccagggaacc ctggtgacag tgtccagcgc cagcactaag      360

gggccctctg tgtttccact cgccccttct agcaaaagca cttccggagg aactgccgct      420

ctgggctgtc tggtgaaaga ttacttcccc gaaccagtca ctgtgtcatg gaactctgga      480

gcactgacat ctggagttca cacctttcct gctgtgctgc agagttctgg actgtactcc      540

ctgtcatctg tggtcaccgt gccatcttca tctctgggga cccagaccta catctgtaac      600

gtgaaccaca aaccctccaa cacaaaagtg gacaaacgag tcgaaccaaa atcttgtgac      660

aaaacccaca catgcccacc gtgcccagct ccggaactcc tgggcggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccaagtc gggatgagct gaccaagaac     1080

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag cgcgctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  65
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5-LC

<400>  65

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  66
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding 5E5-LC

<400>  66
gaactcgtga tgacccagag ccccagctct ctgacagtga cagccggcga gaaagtgacc       60

atgatctgca agtcctccca gagcctgctg aactccggcg accagaagaa ctacctgacc      120

tggtatcagc agaaacccgg ccagcccccc aagctgctga tcttttgggc cagcacccgg      180

gaaagcggcg tgcccgatag attcacaggc agcggctccg gcaccgactt taccctgacc      240

atcagctccg tgcaggccga ggacctggcc gtgtattact gccagaacga ctacagctac      300

cccctgacct tcggagccgg caccaagctg gaactgaagc gtacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gtaccgctag cgttgtgtgc      420

ctgctgaata acttttatcc acgggaggct aaggtgcagt ggaaagtgga caatgccctc      480

cagagcggaa atagccaaga gtccgttacc gaacaggact ctaaagactc tacatactcc      540

ctgtcctcca cactgaccct ctccaaggcc gactatgaga aacacaaggt ttacgcatgc      600

gaggtcacac accagggact ctcctctccc gtgaccaaga gcttcaaccg gggagaatgc      660


<210>  67
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5-Fc9

<400>  67

Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  68
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding 5E5-Fc9

<400>  68
caggtgcagc tgcagcagtc tgatgccgag ctcgtgaagc ctggcagcag cgtgaagatc       60

agctgcaagg ccagcggcta caccttcacc gaccacgcca tccactgggt caagcagaag      120

cctgagcagg gcctggaatg gatcggccac ttcagccccg gcaacaccga catcaagtac      180

aacgacaagt tcaagggcaa ggccaccctg accgtggaca gaagcagcag caccgcctac      240

atgcagctga acagcctgac cagcgaggac agcgccgtgt acttctgcaa gaccagcacc      300

ttctttttcg actactgggg ccagggcaca accctgacag tgtctagcgc cagcactaag      360

gggccctctg tgtttccact cgccccttct agcaaaagca cttccggagg aactgccgct      420

ctgggctgtc tggtgaaaga ttacttcccc gaaccagtca ctgtgtcatg gaactctgga      480

gcactgacat ctggagttca cacctttcct gctgtgctgc agagttctgg actgtactcc      540

ctgtcatctg tggtcaccgt gccatcttca tctctgggga cccagaccta catctgtaac      600

gtgaaccaca aaccctccaa cacaaaagtg gacaaacgag tcgaaccaaa atcttgtgac      660

aaaacccaca catgcccacc gtgcccagct ccggaactcc tgggcggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccaagtc gggatgagct gaccaagaac     1080

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgtt ggactccgac     1200

ggctccttct tcctctacag cgcgctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  69
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab-LC

<400>  69

Gln Val Val Leu Thr Gln Ser Pro Val Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Gly 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Asp Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  70
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding E-mab-LC

<400>  70
caggtggtgc tgacccagag ccccgtgatc atgtccgcca gccctggcga gaaggtgacc       60

atgacctgca gcgccagcag cagcatcagc tacatgtact ggtatcaaca gaagcccggc      120

accagcccca agaggtggat ctacgacacc agcaagctgg ctagcggcgt gcctgccaga      180

ttcagcggaa gcggcagcgg caccagctac agcctgacca tcagcaacat ggaggccggc      240

gacgccgcca catactactg ccaccagagg gactcctacc cctggacctt cggcggaggc      300

accaacctgg agatcaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg taccgctagc gttgtgtgcc tgctgaataa cttttatcca      420

cgggaggcta aggtgcagtg gaaagtggac aatgccctcc agagcggaaa tagccaagag      480

tccgttaccg aacaggactc taaagactct acatactccc tgtcctccac actgaccctc      540

tccaaggccg actatgagaa acacaaggtt tacgcatgcg aggtcacaca ccagggactc      600

tcctctcccg tgaccaagag cttcaaccgg ggagaatgc                             639


<210>  71
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab-Fc9

<400>  71

Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Lys Phe 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Ser Tyr Asn Ser Gly Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Glu Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Lys Pro Gly Gly Asp Tyr Trp Gly His Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  72
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding E-mab-Fc9

<400>  72
caggtgcagc tgaaggagag cggacctgac ctggtggccc ctagccagag cctgagcatc       60

acctgcaccg tgagcggctt cagcctgagc aagttcggcg tgaactgggt gagacagccc      120

cccggaaagg gactggagtg gctgggagtg atctggggcg acggcagcac cagctacaac      180

agcggcctga tcagcaggct gtccatcagc aaggagaaca gcaagagcca ggtgttcctg      240

aagctgaaca gcctgcaggc cgacgacacc gccacctact actgcgtgaa gcctggcggc      300

gattactggg gccacggaac cagcgtgacc gtgagcagcg ccagcactaa ggggccctct      360

gtgtttccac tcgccccttc tagcaaaagc acttccggag gaactgccgc tctgggctgt      420

ctggtgaaag attacttccc cgaaccagtc actgtgtcat ggaactctgg agcactgaca      480

tctggagttc acacctttcc tgctgtgctg cagagttctg gactgtactc cctgtcatct      540

gtggtcaccg tgccatcttc atctctgggg acccagacct acatctgtaa cgtgaaccac      600

aaaccctcca acacaaaagt ggacaaacga gtcgaaccaa aatcttgtga caaaacccac      660

acatgcccac cgtgcccagc tccggaactc ctgggcggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccaagt cgggatgagc tgaccaagaa ccaggtcagc     1080

ctgtggtgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc     1200

ttcctctaca gcgcgctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaa                                                             1329


<210>  73
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab-LC

<400>  73

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  74
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding A-mab-LC

<400>  74
gacatcgagc tgacacagag ccctgccatc atgtctgcta gccctggcga gaaagtgacc       60

atgacctgta gcgccagcag cagcgtgtcc tacatgcact ggtatcagca gaagtccggc      120

acaagcccca agcggtggat ctacgataca agcaagctgg cctctggcgt gcccggcaga      180

ttttctggtt ctggcagcgg caacagctac agcctgacaa tcagctccgt ggaagccgag      240

gacgacgcca cctactattg ccagcagtgg tctaagcacc ctctgacctt tggctccggc      300

accaaggtgg aaatcaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg taccgctagc gttgtgtgcc tgctgaataa cttttatcca      420

cgggaggcta aggtgcagtg gaaagtggac aatgccctcc agagcggaaa tagccaagag      480

tccgttaccg aacaggactc taaagactct acatactccc tgtcctccac actgaccctc      540

tccaaggccg actatgagaa acacaaggtt tacgcatgcg aggtcacaca ccagggactc      600

tcctctcccg tgaccaagag cttcaaccgg ggagaatgc                             639


<210>  75
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab-Fc9

<400>  75

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  76
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding A-mab-Fc9

<400>  76
caggttcagc tgcagcagtc tggacccgag ctggaaaaac ctggcgcctc cgtgaagatc       60

agctgcaagg ccagcggcta cagcttcacc ggctacacca tgaactgggt caagcagagc      120

cacggcaaga gcctggaatg gatcggcctg atcacccctt acaatggcgc cagcagctac      180

aaccagaagt tcagaggcaa ggccacactg accgtggaca agagcagcag caccgcctac      240

atggatctgc tgagcctgac cagcgaggac agcgccgtgt acttttgtgc cagaggcggc      300

tatgacggca gaggctttga ttactggggc agcggaaccc ctgtgaccgt ttcttctgcc      360

agcactaagg ggccctctgt gtttccactc gccccttcta gcaaaagcac ttccggagga      420

actgccgctc tgggctgtct ggtgaaagat tacttccccg aaccagtcac tgtgtcatgg      480

aactctggag cactgacatc tggagttcac acctttcctg ctgtgctgca gagttctgga      540

ctgtactccc tgtcatctgt ggtcaccgtg ccatcttcat ctctggggac ccagacctac      600

atctgtaacg tgaaccacaa accctccaac acaaaagtgg acaaacgagt cgaaccaaaa      660

tcttgtgaca aaacccacac atgcccaccg tgcccagctc cggaactcct gggcggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccaagtcg ggatgagctg     1080

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgttg     1200

gactccgacg gctccttctt cctctacagc gcgctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  77
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muIFNa4-Fc6

<400>  77

Met Ala Arg Leu Cys Ala Phe Leu Met Ile Leu Val Met Met Ser Tyr 
1               5                   10                  15      


Tyr Trp Ser Ala Cys Ser Leu Gly Cys Asp Leu Pro His Thr Tyr Asn 
            20                  25                  30          


Leu Gly Asn Lys Arg Ala Leu Thr Val Leu Glu Glu Met Arg Arg Leu 
        35                  40                  45              


Pro Pro Leu Ser Cys Leu Lys Asp Arg Lys Asp Phe Gly Phe Pro Leu 
    50                  55                  60                  


Glu Lys Val Asp Asn Gln Gln Ile Gln Lys Ala Gln Ala Ile Leu Val 
65                  70                  75                  80  


Leu Arg Asp Leu Thr Gln Gln Ile Leu Asn Leu Phe Thr Ser Lys Asp 
                85                  90                  95      


Leu Ser Ala Thr Trp Asn Ala Thr Leu Leu Asp Ser Phe Cys Asn Asp 
            100                 105                 110         


Leu His Gln Gln Leu Asn Asp Leu Lys Ala Cys Val Met Gln Glu Pro 
        115                 120                 125             


Pro Leu Thr Gln Glu Asp Ser Leu Leu Ala Val Arg Thr Tyr Phe His 
    130                 135                 140                 


Arg Ile Thr Val Tyr Leu Arg Lys Lys Lys His Ser Leu Cys Ala Trp 
145                 150                 155                 160 


Glu Val Ile Arg Ala Glu Val Trp Arg Ala Leu Ser Ser Ser Thr Asn 
                165                 170                 175     


Leu Leu Ala Arg Leu Ser Glu Glu Lys Glu Gly Gly Gly Gly Ser Glu 
            180                 185                 190         


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        195                 200                 205             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    210                 215                 220                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
225                 230                 235                 240 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                245                 250                 255     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            260                 265                 270         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        275                 280                 285             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    290                 295                 300                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
305                 310                 315                 320 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                325                 330                 335     


Asn Gln Val Ser Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser Asp 
            340                 345                 350         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        355                 360                 365             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Ala Ser 
    370                 375                 380                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
385                 390                 395                 400 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                405                 410                 415     


Leu Ser Leu Ser Pro Gly Lys 
            420             


<210>  78
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding muIFNa4-Fc6

<400>  78
atggctaggc tctgtgcttt cctcatgatc ctggtaatga tgagctacta ctggtcagcc       60

tgttctctag gatgtgacct gcctcacact tataacctcg ggaacaagag ggccttgaca      120

gtcctggaag aaatgagaag actcccccct ctttcctgcc tgaaggacag gaaggatttt      180

ggattcccct tggagaaggt ggataaccaa cagatccaga aggctcaagc catccttgtg      240

ctaagagatc ttacccagca gattttgaac ctcttcacat caaaagactt gtctgctact      300

tggaatgcaa ctctactaga ctcattctgc aatgacctcc atcagcagct caatgacctc      360

aaagcctgtg tgatgcagga acctcctctg acccaggaag actccctgct ggctgtgagg      420

acatacttcc acaggatcac tgtgtacctg agaaagaaga aacacagcct ctgtgcctgg      480

gaggtgatca gagcagaagt ctggagagcc ctctcttcct caaccaactt gctggcaaga      540

ctgagtgagg agaaggaggg aggaggagga agcgaaccta agagcagcga caagacccac      600

acttgccccc cttgtcccgc tccggaactc ctgggcggac cgtcagtctt cctcttcccc      660

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      720

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      780

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      840

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      900

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      960

gaaccacagg tgtataccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1020

ctgagttgcg gggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1080

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc     1140

aagctcgcca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1200

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1260

ccgggtaaa                                                             1269


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  79

Gly Ser Gly Gly Gly 
1               5   


<210>  80
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIFNa2-Fc6

<400>  80

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu Gly Gly Gly Gly 
            180                 185                 190         


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Lys Leu 
    370                 375                 380                 


Ala Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425 


<210>  81
<211>  1275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding huIFNa2-Fc6

<400>  81
atggccttga cctttgcttt actggtggcc ctcctggtgc tcagctgcaa gtcaagctgc       60

tctgtgggct gtgatctgcc tcaaacccac agcctgggta gcaggaggac cttgatgctc      120

ctggcacaga tgaggagaat ctctcttttc tcctgcttga aggacagaca tgactttgga      180

tttccccagg aggagtttgg caaccagttc caaaaggctg aaaccatccc tgtcctccat      240

gagatgatcc agcagatctt caatctcttc agcacaaagg actcatctgc tgcttgggat      300

gagaccctcc tagacaaatt ctacactgaa ctctaccagc agctgaatga cctggaagcc      360

tgtgtgatac agggggtggg ggtgacagag actcccctga tgaaggagga ctccattctg      420

gctgtgagga aatacttcca aagaatcact ctctatctga aagagaagaa atacagccct      480

tgtgcctggg aggttgtcag agcagaaatc atgagatctt tttctttgtc aacaaacttg      540

caagaaagtt taagaagtaa ggaaggagga ggaggaagcg aacctaagag cagcgacaag      600

acccacactt gccccccttg tcccgctccg gaactcctgg gcggaccgtc agtcttcctc      660

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      720

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      780

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      840

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      900

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      960

ccccgagaac cacaggtgta taccctgccc ccatcccggg atgagctgac caagaaccag     1020

gtcagcctga gttgcggggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1080

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgttgga ctccgacggc     1140

tccttcaagc tcgccagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1200

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1260

ctgtctccgg gtaaa                                                      1275


<210>  82
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muIFNb-Fc6

<400>  82

Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg 
            20                  25                  30          


Thr Asn Ile Arg Lys Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys 
        35                  40                  45              


Ile Asn Leu Thr Tyr Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr 
    50                  55                  60                  


Glu Lys Met Gln Lys Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu 
65                  70                  75                  80  


Gln Asn Val Phe Leu Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp 
                85                  90                  95      


Asn Glu Thr Ile Val Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr 
            100                 105                 110         


Val Phe Leu Lys Thr Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr 
        115                 120                 125             


Trp Glu Met Ser Ser Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg 
    130                 135                 140                 


Val Gln Arg Tyr Leu Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met 
145                 150                 155                 160 


Val Val Arg Ala Glu Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu 
                165                 170                 175     


Thr Arg Asn Phe Gln Asn Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser 
            180                 185                 190         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        195                 200                 205             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        355                 360                 365             


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Ala Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


<210>  83
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding muIFNb-Fc6

<400>  83
atgaacaaca ggtggattct ccacgctgcg ttcctgctgt gcttctccac cacagccctc       60

tccatcaact ataagcagct ccagctccaa gaaaggacga acattcggaa atgtcaggag      120

ctcctggagc agctgaatgg aaagatcaac ctcacctaca gggcggactt caagatccct      180

atggagatga cggagaagat gcagaagagt tacactgcct ttgccatcca agagatgctc      240

cagaatgtct ttcttgtctt cagaaacaat ttctccagca ctgggtggaa tgagactatt      300

gttgtacgtc tcctggatga actccaccag cagacagtgt ttctgaagac agtactagag      360

gaaaagcaag aggaaagatt gacgtgggag atgtcctcaa ctgctctcca cttgaagagc      420

tattactgga gggtgcaaag gtatcttaaa ctcatgaagt acaacagcta cgcctggatg      480

gtggtccgag cagagatctt caggaacttt ctcatcattc gaagacttac cagaaacttc      540

caaaacggag gaggaggaag cgaacctaag agcagcgaca agacccacac ttgcccccct      600

tgtcccgctc cggaactcct gggcggaccg tcagtcttcc tcttcccccc aaaacccaag      660

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      720

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      780

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      840

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      900

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      960

tataccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gagttgcggg     1020

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1080

aacaactaca agaccacgcc tcccgtgttg gactccgacg gctccttcaa gctcgccagc     1140

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1200

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1257


<210>  84
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIFNb-Fc6

<400>  84

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn Gly Gly Gly Gly Ser 
            180                 185                 190         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        195                 200                 205             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    210                 215                 220                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
225                 230                 235                 240 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                245                 250                 255     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            260                 265                 270         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        275                 280                 285             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    290                 295                 300                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
305                 310                 315                 320 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                325                 330                 335     


Lys Asn Gln Val Ser Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser 
            340                 345                 350         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        355                 360                 365             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Ala 
    370                 375                 380                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
385                 390                 395                 400 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                405                 410                 415     


Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 


<210>  85
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding huIFNb-Fc6

<400>  85
ttggattcct acaaagaagc agcaattttc agtgtcagaa gctcctgtgg caattgaatg       60

ggaggcttga atactgcctc aaggacagga tgaactttga catccctgag gagattaagc      120

agctgcagca gttccagaag gaggacgccg cattgaccat ctatgagatg ctccagaaca      180

tctttgctat tttcagacaa gattcatcta gcactggctg gaatgagact attgttgaga      240

acctcctggc taatgtctat catcagataa accatctgaa gacagtcctg gaagaaaaac      300

tggagaaaga agatttcacc aggggaaaac tcatgagcag tctgcacctg aaaagatatt      360

atgggaggat tctgcattac ctgaaggcca aggagtacag tcactgtgcc tggaccatag      420

tcagagtgga aatcctaagg aacttttact tcattaacag acttacaggt tacctccgaa      480

acggatccgg tggaggtgac aagacccaca cctgcccccc ctgccccgcc cccgagctgc      540

tgggcggccc cagcgtgttc cggaggagga ggaagcgaac ctaagagcag cgacaagacc      600

cacacttgcc ccccttgtcc cgctccggaa ctcctgggcg gaccgtcagt cttcctcttc      660

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      720

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      780

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      840

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      900

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc      960

cgagaaccac aggtgtatac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1020

agcctgagtt gcggggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1080

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgttggactc cgacggctcc     1140

ttcaagctcg ccagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1200

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1260

tctccgggta aa                                                         1272


<210>  86
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIFNL-Fc6

<400>  86

Met Ala Ala Ala Trp Thr Val Val Leu Val Thr Leu Val Leu Gly Leu 
1               5                   10                  15      


Ala Val Ala Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys 
            20                  25                  30          


Gly Cys His Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala 
        35                  40                  45              


Ser Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys 
    50                  55                  60                  


Asn Trp Ser Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg 
65                  70                  75                  80  


Leu Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala 
                85                  90                  95      


Leu Thr Leu Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp 
            100                 105                 110         


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
        115                 120                 125             


Gln Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly 
    130                 135                 140                 


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
145                 150                 155                 160 


Ser Ala Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
                165                 170                 175     


Leu Thr Arg Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg 
            180                 185                 190         


Thr Ser Thr His Pro Glu Ser Thr Gly Gly Gly Gly Ser Glu Pro Lys 
        195                 200                 205             


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    210                 215                 220                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
225                 230                 235                 240 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                245                 250                 255     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            260                 265                 270         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        275                 280                 285             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    290                 295                 300                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
305                 310                 315                 320 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                325                 330                 335     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            340                 345                 350         


Val Ser Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        355                 360                 365             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    370                 375                 380                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Ala Ser Lys Leu 
385                 390                 395                 400 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                405                 410                 415     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            420                 425                 430         


Leu Ser Pro Gly Lys 
        435         


<210>  87
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding huIFNL-Fc6

<400>  87
atggctgcag cttggaccgt ggtgctggtg actttggtgc taggcttggc cgtggcaggc       60

cctgtcccca cttccaagcc caccacaact gggaagggct gccacattgg caggttcaaa      120

tctctgtcac cacaggagct agcgagcttc aagaaggcca gggacgcctt ggaagagtca      180

ctcaagctga aaaactggag ttgcagctct cctgtcttcc ccgggaattg ggacctgagg      240

cttctccagg tgagggagcg ccctgtggcc ttggaggctg agctggccct gacgctgaag      300

gtcctggagg ccgctgctgg cccagccctg gaggacgtcc tagaccagcc ccttcacacc      360

ctgcaccaca tcctctccca gctccaggcc tgtatccagc ctcagcccac agcagggccc      420

aggccccggg gccgcctcca ccactggctg caccggctcc aggaggcccc caaaaaggag      480

tccgctggct gcctggaggc atctgtcacc ttcaacctct tccgcctcct cacgcgagac      540

ctcaaatatg tggccgatgg gaacctgtgt ctgagaacgt caacccaccc tgagtccacc      600

ggaggaggag gaagcgaacc taagagcagc gacaagaccc acacttgccc cccttgtccc      660

gctccggaac tcctgggcgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      720

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      780

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      840

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      900

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc      960

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtatacc     1020

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgagttg cggggtcaaa     1080

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1140

tacaagacca cgcctcccgt gttggactcc gacggctcct tcaagctcgc cagcaagctc     1200

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1260

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1311


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  88

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  89
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIL10-Fc6

<400>  89

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
                165                 170                 175     


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            180                 185                 190         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        195                 200                 205             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    210                 215                 220                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
225                 230                 235                 240 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                245                 250                 255     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            260                 265                 270         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        275                 280                 285             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    290                 295                 300                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
305                 310                 315                 320 


Asn Gln Val Ser Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser Asp 
                325                 330                 335     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            340                 345                 350         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Ala Ser 
        355                 360                 365             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    370                 375                 380                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
385                 390                 395                 400 


Leu Ser Leu Ser Pro Gly Lys 
                405         


<210>  90
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding huIL10-Fc6

<400>  90
agccccggcc agggcacaca gtccgagaac agctgcaccc actttcccgg caacctgcct       60

aacatgctga gggacctgag ggacgccttc agcagggtga agaccttctt ccagatgaag      120

gaccagctgg ataacctgct gctgaaggag agcctgctgg aggacttcaa gggctacctg      180

ggctgccagg ccctgagcga gatgatccag ttctacctgg aggaggtgat gccccaggcc      240

gagaaccagg accccgacat caaggcccac gtgaacagcc tgggcgagaa cctgaagacc      300

ctgaggctga ggctgaggag gtgccacagg ttcctgccct gtgagaacaa atccaaggcc      360

gtggagcagg tgaagaacgc cttcaacaag ctgcaggaaa agggcatcta caaggccatg      420

agcgagttcg acatctttat caactatatc gaggcctaca tgacaatgaa gatcaggaac      480

ggcggcggcg gcagcggggg cggcggcagc ggaggaggcg gcagcgaacc taagagcagc      540

gacaagaccc acacttgccc cccttgtccc gctccggaac tcctgggcgg accgtcagtc      600

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      660

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      720

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      780

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      840

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      900

gggcagcccc gagaaccaca ggtgtatacc ctgcccccat cccgggatga gctgaccaag      960

aaccaggtca gcctgagttg cggggtcaaa ggcttctatc ccagcgacat cgccgtggag     1020

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc     1080

gacggctcct tcaagctcgc cagcaagctc accgtggaca agagcaggtg gcagcagggg     1140

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1200

ctctccctgt ctccgggtaa a                                               1221


<210>  91
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (huIL10)2-Fc6

<400>  91

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                165                 170                 175     


Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro Gly 
            180                 185                 190         


Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val 
        195                 200                 205             


Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu Lys 
    210                 215                 220                 


Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu 
225                 230                 235                 240 


Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu 
                245                 250                 255     


Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu Asn 
            260                 265                 270         


Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro 
        275                 280                 285             


Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn 
    290                 295                 300                 


Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile 
305                 310                 315                 320 


Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro 
            340                 345                 350         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        355                 360                 365             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    370                 375                 380                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                405                 410                 415     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            420                 425                 430         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        435                 440                 445             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    450                 455                 460                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
465                 470                 475                 480 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                485                 490                 495     


Gln Val Ser Leu Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            500                 505                 510         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        515                 520                 525             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Ala Ser Lys 
    530                 535                 540                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
545                 550                 555                 560 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                565                 570                 575     


Ser Leu Ser Pro Gly Lys 
            580         


<210>  92
<211>  1746
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding (huIL10)2-Fc6

<400>  92
agccccggcc agggcacaca gtccgagaac agctgcaccc actttcccgg caacctgcct       60

aacatgctga gggacctgag ggacgccttc agcagggtga agaccttctt ccagatgaag      120

gaccagctgg ataacctgct gctgaaggag agcctgctgg aggacttcaa gggctacctg      180

ggctgccagg ccctgagcga gatgatccag ttctacctgg aggaggtgat gccccaggcc      240

gagaaccagg accccgacat caaggcccac gtgaacagcc tgggcgagaa cctgaagacc      300

ctgaggctga ggctgaggag gtgccacagg ttcctgccct gtgagaacaa atccaaggcc      360

gtggagcagg tgaagaacgc cttcaacaag ctgcaggaaa agggcatcta caaggccatg      420

agcgagttcg acatctttat caactatatc gaggcctaca tgacaatgaa gatcaggaac      480

ggcggcggcg gcagcggggg cggcggcagc ggaggaggcg gcagcagccc cggccagggc      540

acacagtccg agaacagctg cacccacttt cccggcaacc tgcctaacat gctgagggac      600

ctgagggacg ccttcagcag ggtgaagacc ttcttccaga tgaaggacca gctggataac      660

ctgctgctga aggagagcct gctggaggac ttcaagggct acctgggctg ccaggccctg      720

agcgagatga tccagttcta cctggaggag gtgatgcccc aggccgagaa ccaggacccc      780

gacatcaagg cccacgtgaa cagcctgggc gagaacctga agaccctgag gctgaggctg      840

aggaggtgcc acaggttcct gccctgtgag aacaaatcca aggccgtgga gcaggtgaag      900

aacgccttca acaagctgca ggaaaagggc atctacaagg ccatgagcga gttcgacatc      960

tttatcaact atatcgaggc ctacatgaca atgaagatca ggaacggcgg cggcggcagc     1020

gggggcggcg gcagcggagg aggcggcagc gaacctaaga gcagcgacaa gacccacact     1080

tgcccccctt gtcccgctcc ggaactcctg ggcggaccgt cagtcttcct cttcccccca     1140

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1200

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1260

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1320

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1380

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1440

ccacaggtgt ataccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1500

agttgcgggg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1560

cagccggaga acaactacaa gaccacgcct cccgtgttgg actccgacgg ctccttcaag     1620

ctcgccagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1680

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1740

ggtaaa                                                                1746


<210>  93
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (huIL10)2-Fc9

<400>  93

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                165                 170                 175     


Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro Gly 
            180                 185                 190         


Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val 
        195                 200                 205             


Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu Lys 
    210                 215                 220                 


Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu 
225                 230                 235                 240 


Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu 
                245                 250                 255     


Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu Asn 
            260                 265                 270         


Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro 
        275                 280                 285             


Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn 
    290                 295                 300                 


Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile 
305                 310                 315                 320 


Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
            340                 345                 350         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asn 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  94
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding (huIL10)2-Fc9

<400>  94
agccccggcc agggcacaca gtccgagaac agctgcaccc actttcccgg caacctgcct       60

aacatgctga gggacctgag ggacgccttc agcagggtga agaccttctt ccagatgaag      120

gaccagctgg ataacctgct gctgaaggag agcctgctgg aggacttcaa gggctacctg      180

ggctgccagg ccctgagcga gatgatccag ttctacctgg aggaggtgat gccccaggcc      240

gagaaccagg accccgacat caaggcccac gtgaacagcc tgggcgagaa cctgaagacc      300

ctgaggctga ggctgaggag gtgccacagg ttcctgccct gtgagaacaa atccaaggcc      360

gtggagcagg tgaagaacgc cttcaacaag ctgcaggaaa agggcatcta caaggccatg      420

agcgagttcg acatctttat caactatatc gaggcctaca tgacaatgaa gatcaggaac      480

ggcggcggcg gcagcggggg cggcggcagc ggaggaggcg gcagcagccc cggccagggc      540

acacagtccg agaacagctg cacccacttt cccggcaacc tgcctaacat gctgagggac      600

ctgagggacg ccttcagcag ggtgaagacc ttcttccaga tgaaggacca gctggataac      660

ctgctgctga aggagagcct gctggaggac ttcaagggct acctgggctg ccaggccctg      720

agcgagatga tccagttcta cctggaggag gtgatgcccc aggccgagaa ccaggacccc      780

gacatcaagg cccacgtgaa cagcctgggc gagaacctga agaccctgag gctgaggctg      840

aggaggtgcc acaggttcct gccctgtgag aacaaatcca aggccgtgga gcaggtgaag      900

aacgccttca acaagctgca ggaaaagggc atctacaagg ccatgagcga gttcgacatc      960

tttatcaact atatcgaggc ctacatgaca atgaagatca ggaacggcgg cggcggcagc     1020

gggggcggcg gcagcggagg aggcggcagc gacaaaaccc acacatgccc accgtgccca     1080

gctccggaac tcctgggcgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1140

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1200

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1260

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1320

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1380

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1440

ctgcccccaa gtcgggatga gctgaccaag aaccaggtca gcctgtggtg cctggtcaaa     1500

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1560

tacaagacca cgcctcccgt gttggactcc gacggctcct tcttcctcta cagcgcgctc     1620

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1680

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1731


<210>  95
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (huIL10)2-Fc-hole

<400>  95

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                165                 170                 175     


Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro Gly 
            180                 185                 190         


Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val 
        195                 200                 205             


Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu Lys 
    210                 215                 220                 


Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu 
225                 230                 235                 240 


Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu 
                245                 250                 255     


Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu Asn 
            260                 265                 270         


Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro 
        275                 280                 285             


Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn 
    290                 295                 300                 


Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile 
305                 310                 315                 320 


Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
            340                 345                 350         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 
                485                 490                 495     


Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  96
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding (huIL10)2-Fc-hole

<400>  96
agccccggcc agggcacaca gtccgagaac agctgcaccc actttcccgg caacctgcct       60

aacatgctga gggacctgag ggacgccttc agcagggtga agaccttctt ccagatgaag      120

gaccagctgg ataacctgct gctgaaggag agcctgctgg aggacttcaa gggctacctg      180

ggctgccagg ccctgagcga gatgatccag ttctacctgg aggaggtgat gccccaggcc      240

gagaaccagg accccgacat caaggcccac gtgaacagcc tgggcgagaa cctgaagacc      300

ctgaggctga ggctgaggag gtgccacagg ttcctgccct gtgagaacaa atccaaggcc      360

gtggagcagg tgaagaacgc cttcaacaag ctgcaggaaa agggcatcta caaggccatg      420

agcgagttcg acatctttat caactatatc gaggcctaca tgacaatgaa gatcaggaac      480

ggcggcggcg gcagcggggg cggcggcagc ggaggaggcg gcagcagccc cggccagggc      540

acacagtccg agaacagctg cacccacttt cccggcaacc tgcctaacat gctgagggac      600

ctgagggacg ccttcagcag ggtgaagacc ttcttccaga tgaaggacca gctggataac      660

ctgctgctga aggagagcct gctggaggac ttcaagggct acctgggctg ccaggccctg      720

agcgagatga tccagttcta cctggaggag gtgatgcccc aggccgagaa ccaggacccc      780

gacatcaagg cccacgtgaa cagcctgggc gagaacctga agaccctgag gctgaggctg      840

aggaggtgcc acaggttcct gccctgtgag aacaaatcca aggccgtgga gcaggtgaag      900

aacgccttca acaagctgca ggaaaagggc atctacaagg ccatgagcga gttcgacatc      960

tttatcaact atatcgaggc ctacatgaca atgaagatca ggaacggcgg cggcggcagc     1020

gggggcggcg gcagcggagg aggcggcagc gacaagaccc acacctgccc cccttgcccc     1080

gctccggagc tgctgggcgg ccccagcgtg ttcctgttcc cccccaagcc caaggacacc     1140

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac     1200

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag     1260

ccccgcgagg agcagtacaa cagcacctac cgcgtggtga gcgtgctgac cgtgctgcac     1320

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgcc     1380

cccatcgaga agaccatcag caaggccaag ggccagcccc gcgagcccca ggtgtgcacc     1440

ctgcccccca gccgcgacga gctgaccaag aaccaggtga gcctgagctg cgccgtgaag     1500

ggcttctacc ccagcgacat cgccgtggag tgggagagca acggccagcc cgagaacaac     1560

tacaagacca ccccccccgt gctggacagc gacggcagct tcttcctggt gagcaagctg     1620

accgtggaca agagccgctg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1680

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggcaa g              1731


<210>  97
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  husIL2-Fc6

<400>  97

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
    130                 135                 140                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
145                 150                 155                 160 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                165                 170                 175     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            180                 185                 190         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        195                 200                 205             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    210                 215                 220                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
225                 230                 235                 240 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                245                 250                 255     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            260                 265                 270         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        275                 280                 285             


Ser Cys Gly Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    290                 295                 300                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Phe Lys Leu Ala Ser Lys Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            340                 345                 350         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        355                 360                 365             


Gly Lys 
    370 


<210>  98
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding husIL2-Fc6

<400>  98
gcccctacaa gcagcagcac caagaagacc cagctgcagc tggaacacct gctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accttcaagt tctacatgcc caagaaggcc accgagctga agcacctcca gtgtctggag      180

gaggagctga agcctctgga ggaagtgctg aacctggccc agagcaagaa cttccacttc      240

gaccccaggg acgtggtgtc caacatcaac gtgttcgtgc tggaactgaa gggcagcgag      300

accaccttca tgtgcgagta cgccgacgag accgctacca tcgtggagtt cctgaaccgc      360

tggatcacct tttgccagag catcatcagc acactgaccg gaggaggagg aagcgaacct      420

aagagcagcg acaagaccca cacttgcccc ccttgtcccg ctccggaact cctgggcgga      480

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      540

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      600

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      660

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      720

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      780

aaagccaaag ggcagccccg agaaccacag gtgtataccc tgcccccatc ccgggatgag      840

ctgaccaaga accaggtcag cctgagttgc ggggtcaaag gcttctatcc cagcgacatc      900

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      960

ttggactccg acggctcctt caagctcgcc agcaagctca ccgtggacaa gagcaggtgg     1020

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1080

cagaagagcc tctccctgtc tccgggtaaa                                      1110


<210>  99
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  husIL2-Fc-hole

<400>  99

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
    130                 135                 140                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
145                 150                 155                 160 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                165                 170                 175     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            180                 185                 190         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        195                 200                 205             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    210                 215                 220                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
225                 230                 235                 240 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                245                 250                 255     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            260                 265                 270         


Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser Leu 
        275                 280                 285             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    290                 295                 300                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            340                 345                 350         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        355                 360                 365             


Gly Lys 
    370 


<210>  100
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid molecules encoding husIL2-Fc-hole

<400>  100
gcccctacaa gcagcagcac caagaagacc cagctgcagc tggaacacct gctgctggat       60

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      120

accttcaagt tctacatgcc caagaaggcc accgagctga agcacctcca gtgtctggag      180

gaggagctga agcctctgga ggaagtgctg aacctggccc agagcaagaa cttccacttc      240

gaccccaggg acgtggtgtc caacatcaac gtgttcgtgc tggaactgaa gggcagcgag      300

accaccttca tgtgcgagta cgccgacgag accgctacca tcgtggagtt cctgaaccgc      360

tggatcacct tttgccagag catcatcagc acactgaccg gaggaggagg aagcgagcct      420

aagtccagcg acaagaccca cacctgcccc ccttgccccg ctccggaact cctgggcgga      480

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      540

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      600

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      660

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      720

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      780

aaagccaaag ggcagccccg agaaccacag gtgtataccc tgcccccatc ccggtgtgag      840

ctgaccaaga accaggtcag cctgagttgc gcggtcaaag gcttctatcc cagcgacatc      900

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      960

ttggactccg acggctcctt cttcctcgtc agcaagctca ccgtggacaa gagcaggtgg     1020

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1080

cagaagagcc tctccctgtc tccgggtaaa                                      1110


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab light chain CDR1

<400>  101

Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His 
1               5                   10      


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab light chain CDR2

<400>  102

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab light chain CDR3

<400>  103

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  104
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab light chain variable region

<400>  104

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  105
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab heavy chain CDR1

<400>  105

Asn Tyr Gly Val His 
1               5   


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab heavy chain CDR2

<400>  106

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
1               5                   10                  15      


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab heavy chain CDR3

<400>  107

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
1               5                   10      


<210>  108
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab heavy chain variable region

<400>  108

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806 light chain CDR1

<400>  109

His Ser Ser Gln Asp Ile Asn Ser Asn Ile Gly 
1               5                   10      


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806 light chain CDR2

<400>  110

His Gly Thr Asn Leu Asp Asp 
1               5           


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806 light chain CDR3

<400>  111

Val Gln Tyr Ala Gln Phe Pro Trp Thr 
1               5                   


<210>  112
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806 light chain variable region

<400>  112

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  113
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806 heavy chain CDR1

<400>  113

Ser Asp Phe Ala Trp Asn 
1               5       


<210>  114
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806 heavy chain CDR2

<400>  114

Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806 heavy chain CDR3

<400>  115

Ala Gly Arg Gly Phe Pro Tyr 
1               5           


<210>  116
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab806 heavy chain variable region

<400>  116

Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain CDR1

<400>  117

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain CDR2

<400>  118

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain CDR3

<400>  119

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  120
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain variable region

<400>  120

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain CDR1

<400>  121

Asp Thr Tyr Ile His 
1               5   


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain CDR2

<400>  122

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain CDR3

<400>  123

Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  124
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain variable region

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab light chain CDR1

<400>  125

Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala 
1               5                   10      


<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab light chain CDR2

<400>  126

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab light chain CDR3

<400>  127

Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   


<210>  128
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab light chain variable region

<400>  128

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab heavy chain CDR1

<400>  129

Asp Tyr Thr Met Asp 
1               5   


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab heavy chain CDR2

<400>  130

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab heavy chain CDR3

<400>  131

Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  132
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab heavy chain variable region

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  133
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB light chain CDR1

<400>  133

Arg Ser Ser Gln Ser Leu Val His Ser Asn Arg Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB light chain CDR2

<400>  134

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB light chain CDR3

<400>  135

Ser Gln Asn Thr His Val Pro Pro Thr 
1               5                   


<210>  136
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB light chain variable region

<400>  136

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Arg Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  137
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB heavy chain CDR1

<400>  137

Asp Tyr Glu Met His 
1               5   


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB heavy chain CDR2

<400>  138

Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB heavy chain CDR3

<400>  139

Phe Tyr Ser Tyr Thr Tyr 
1               5       


<210>  140
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MAB heavy chain variable region

<400>  140

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  141
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 light chain CDR1

<400>  141

Ser Arg Ser Tyr Leu Ala 
1               5       


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 light chain CDR2

<400>  142

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 light chain CDR3

<400>  143

Gln Gln Gly Gln Val Ile Pro Pro Thr 
1               5                   


<210>  144
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 light chain variable region

<400>  144

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  145
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 heavy chain CDR1

<400>  145

Ser His Ala Met Ser 
1               5   


<210>  146
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 heavy chain CDR2

<400>  146

Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 heavy chain CDR3

<400>  147

Gly Trp Leu Gly Asn Phe Asp Tyr 
1               5               


<210>  148
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1 heavy chain variable region

<400>  148

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gln Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  149
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5 light chain CDR1

<400>  149

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  150
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5 light chain CDR2

<400>  150

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5 light chain CDR3

<400>  151

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  152
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5 light chain variable region

<400>  152

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5 heavy chain CDR1

<400>  153

Asp His Ala Ile His 
1               5   


<210>  154
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5 heavy chain CDR2

<400>  154

His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5 heavy chain CDR3

<400>  155

Ser Thr Phe Phe Phe Asp Tyr 
1               5           


<210>  156
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E5 heavy chain variable region

<400>  156

Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab light chain CDR1

<400>  157

Ser Ala Ser Ser Ser Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab light chain CDR2

<400>  158

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab light chain CDR3

<400>  159

His Gln Arg Asp Ser Tyr Pro Trp Thr 
1               5                   


<210>  160
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab light chain variable region

<400>  160

Gln Val Val Leu Thr Gln Ser Pro Val Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Gly 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Asp Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105     


<210>  161
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab heavy chain CDR1

<400>  161

Lys Phe Gly Val Asn 
1               5   


<210>  162
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab heavy chain CDR2

<400>  162

Val Ile Trp Gly Asp Gly Ser Thr Ser Tyr Asn Ser Gly Leu Ile Ser 
1               5                   10                  15      


<210>  163
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab heavy chain CDR3

<400>  163

Pro Gly Gly Asp Tyr 
1               5   


<210>  164
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-mab heavy chain variable region

<400>  164

Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Lys Phe 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Ser Tyr Asn Ser Gly Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Glu Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Lys Pro Gly Gly Asp Tyr Trp Gly His Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  165
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab light chain CDR1

<400>  165

Ser Tyr Met His Trp 
1               5   


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab light chain CDR2

<400>  166

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab light chain CDR3

<400>  167

Gln Gln Trp Ser Lys His Pro Leu Thr 
1               5                   


<210>  168
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab light chain variable region

<400>  168

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  169
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab heavy chain CDR1

<400>  169

Gly Tyr Thr Met Asn 
1               5   


<210>  170
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab heavy chain CDR2

<400>  170

Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab heavy chain CDR3

<400>  171

Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr 
1               5                   10  


<210>  172
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-mab heavy chain variable region

<400>  172

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  173
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  husIL2

<400>  173

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  174
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muIFNa4

<400>  174

Met Ala Arg Leu Cys Ala Phe Leu Met Ile Leu Val Met Met Ser Tyr 
1               5                   10                  15      


Tyr Trp Ser Ala Cys Ser Leu Gly Cys Asp Leu Pro His Thr Tyr Asn 
            20                  25                  30          


Leu Gly Asn Lys Arg Ala Leu Thr Val Leu Glu Glu Met Arg Arg Leu 
        35                  40                  45              


Pro Pro Leu Ser Cys Leu Lys Asp Arg Lys Asp Phe Gly Phe Pro Leu 
    50                  55                  60                  


Glu Lys Val Asp Asn Gln Gln Ile Gln Lys Ala Gln Ala Ile Leu Val 
65                  70                  75                  80  


Leu Arg Asp Leu Thr Gln Gln Ile Leu Asn Leu Phe Thr Ser Lys Asp 
                85                  90                  95      


Leu Ser Ala Thr Trp Asn Ala Thr Leu Leu Asp Ser Phe Cys Asn Asp 
            100                 105                 110         


Leu His Gln Gln Leu Asn Asp Leu Lys Ala Cys Val Met Gln Glu Pro 
        115                 120                 125             


Pro Leu Thr Gln Glu Asp Ser Leu Leu Ala Val Arg Thr Tyr Phe His 
    130                 135                 140                 


Arg Ile Thr Val Tyr Leu Arg Lys Lys Lys His Ser Leu Cys Ala Trp 
145                 150                 155                 160 


Glu Val Ile Arg Ala Glu Val Trp Arg Ala Leu Ser Ser Ser Thr Asn 
                165                 170                 175     


Leu Leu Ala Arg Leu Ser Glu Glu Lys Glu 
            180                 185     


<210>  175
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIFNa2

<400>  175

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  176
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muIFNb

<400>  176

Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg 
            20                  25                  30          


Thr Asn Ile Arg Lys Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys 
        35                  40                  45              


Ile Asn Leu Thr Tyr Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr 
    50                  55                  60                  


Glu Lys Met Gln Lys Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu 
65                  70                  75                  80  


Gln Asn Val Phe Leu Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp 
                85                  90                  95      


Asn Glu Thr Ile Val Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr 
            100                 105                 110         


Val Phe Leu Lys Thr Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr 
        115                 120                 125             


Trp Glu Met Ser Ser Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg 
    130                 135                 140                 


Val Gln Arg Tyr Leu Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met 
145                 150                 155                 160 


Val Val Arg Ala Glu Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu 
                165                 170                 175     


Thr Arg Asn Phe Gln Asn 
            180         


<210>  177
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIFNb

<400>  177

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  178
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIFNL

<400>  178

Met Ala Ala Ala Trp Thr Val Val Leu Val Thr Leu Val Leu Gly Leu 
1               5                   10                  15      


Ala Val Ala Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys 
            20                  25                  30          


Gly Cys His Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala 
        35                  40                  45              


Ser Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys 
    50                  55                  60                  


Asn Trp Ser Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg 
65                  70                  75                  80  


Leu Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala 
                85                  90                  95      


Leu Thr Leu Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp 
            100                 105                 110         


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
        115                 120                 125             


Gln Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly 
    130                 135                 140                 


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
145                 150                 155                 160 


Ser Ala Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
                165                 170                 175     


Leu Thr Arg Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg 
            180                 185                 190         


Thr Ser Thr His Pro Glu Ser Thr 
        195                 200 


<210>  179
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIL10

<400>  179

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210>  180
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (huIL10)2

<400>  180

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
                165                 170                 175     


Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro Gly 
            180                 185                 190         


Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val 
        195                 200                 205             


Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu Lys 
    210                 215                 220                 


Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu 
225                 230                 235                 240 


Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu 
                245                 250                 255     


Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu Asn 
            260                 265                 270         


Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro 
        275                 280                 285             


Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn 
    290                 295                 300                 


Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile 
305                 310                 315                 320 


Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
                325                 330                 335 


