                         SEQUENCE LISTING

<110>  Technische Universitt Dresden
 
<120>  Verwendung der extrazellulren Domne des Transferrinrezeptor 2 
       zur Diagnostik und Behandlung von primr oder sekundr 
       sklerosierenden Erkrankungen

<130>  00017P0333EPWO

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Gly Ser Cys Gln Ala Cys Gly Asp Ser Val Leu Val Val Ser Glu 
1               5                   10                  15      


Asp Val Asn Tyr Glu Pro Asp Leu Asp Phe His Gln Gly Arg Leu Tyr 
            20                  25                  30          


Trp Ser Asp Leu Gln Ala Met Phe Leu Gln Phe Leu Gly Glu Gly Arg 
        35                  40                  45              


Leu Glu Asp Thr Ile Arg Gln Thr Ser Leu Arg Glu Arg Val Ala Gly 
    50                  55                  60                  


Ser Ala Gly Met Ala Ala Leu Thr Gln Asp Ile Arg Ala Ala Leu Ser 
65                  70                  75                  80  


Arg Gln Lys Leu Asp His Val Trp Thr Asp Thr His Tyr Val Gly Leu 
                85                  90                  95      


Gln Phe Pro Asp Pro Ala His Pro Asn Thr Leu His Trp Val Asp Glu 
            100                 105                 110         


Ala Gly Lys Val Gly Glu Gln Leu Pro Leu Glu Asp Pro Asp Val Tyr 
        115                 120                 125             


Cys Pro Tyr Ser Ala Ile Gly Asn Val Thr Gly Glu Leu Val Tyr Ala 
    130                 135                 140                 


His Tyr Gly Arg Pro Glu Asp Leu Gln Asp Leu Arg Ala Arg Gly Val 
145                 150                 155                 160 


Asp Pro Val Gly Arg Leu Leu Leu Val Arg Val Gly Val Ile Ser Phe 
                165                 170                 175     


Ala Gln Lys Val Thr Asn Ala Gln Asp Phe Gly Ala Gln Gly Val Leu 
            180                 185                 190         


Ile Tyr Pro Glu Pro Ala Asp Phe Ser Gln Asp Pro Pro Lys Pro Ser 
        195                 200                 205             


Leu Ser Ser Gln Gln Ala Val Tyr Gly His Val His Leu Gly Thr Gly 
    210                 215                 220                 


Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn Gln Thr Gln Phe Pro 
225                 230                 235                 240 


Pro Val Ala Ser Ser Gly Leu Pro Ser Ile Pro Ala Gln Pro Ile Ser 
                245                 250                 255     


Ala Asp Ile Ala Ser Arg Leu Leu Arg Lys Leu Lys Gly Pro Val Ala 
            260                 265                 270         


Pro Gln Glu Trp Gln Gly Ser Leu Leu Gly Ser Pro Tyr His Leu Gly 
        275                 280                 285             


Pro Gly Pro Arg Leu Arg Leu Val Val Asn Asn His Arg Thr Ser Thr 
    290                 295                 300                 


Pro Ile Asn Asn Ile Phe Gly Cys Ile Glu Gly Arg Ser Glu Pro Asp 
305                 310                 315                 320 


His Tyr Val Val Ile Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                325                 330                 335     


Ala Lys Ser Ala Val Gly Thr Ala Ile Leu Leu Glu Leu Val Arg Thr 
            340                 345                 350         


Phe Ser Ser Met Val Ser Asn Gly Phe Arg Pro Arg Arg Ser Leu Leu 
        355                 360                 365             


Phe Ile Ser Trp Asp Gly Gly Asp Phe Gly Ser Val Gly Ser Thr Glu 
    370                 375                 380                 


Trp Leu Glu Gly Tyr Leu Ser Val Leu His Leu Lys Ala Val Val Tyr 
385                 390                 395                 400 


Val Ser Leu Asp Asn Ala Val Leu Gly Asp Asp Lys Phe His Ala Lys 
                405                 410                 415     


Thr Ser Pro Leu Leu Thr Ser Leu Ile Glu Ser Val Leu Lys Gln Val 
            420                 425                 430         


Asp Ser Pro Asn His Ser Gly Gln Thr Leu Tyr Glu Gln Val Val Phe 
        435                 440                 445             


Thr Asn Pro Ser Trp Asp Ala Glu Val Ile Arg Pro Leu Pro Met Asp 
    450                 455                 460                 


Ser Ser Ala Tyr Ser Phe Thr Ala Phe Val Gly Val Pro Ala Val Glu 
465                 470                 475                 480 


Phe Ser Phe Met Glu Asp Asp Gln Ala Tyr Pro Phe Leu His Thr Lys 
                485                 490                 495     


Glu Asp Thr Tyr Glu Asn Leu His Lys Val Leu Gln Gly Arg Leu Pro 
            500                 505                 510         


Ala Val Ala Gln Ala Val Ala Gln Leu Ala Gly Gln Leu Leu Ile Arg 
        515                 520                 525             


Leu Ser His Asp Arg Leu Leu Pro Leu Asp Phe Gly Arg Tyr Gly Asp 
    530                 535                 540                 


Val Val Leu Arg His Ile Gly Asn Leu Asn Glu Phe Ser Gly Asp Leu 
545                 550                 555                 560 


Lys Ala Arg Gly Leu Thr Leu Gln Trp Val Tyr Ser Ala Arg Gly Asp 
                565                 570                 575     


Tyr Ile Arg Ala Ala Glu Lys Leu Arg Gln Glu Ile Tyr Ser Ser Glu 
            580                 585                 590         


Glu Arg Asp Glu Arg Leu Thr Arg Met Tyr Asn Val Arg Ile Met Arg 
        595                 600                 605             


Val Glu Phe Tyr Phe Leu Ser Gln Tyr Val Ser Pro Ala Asp Ser Pro 
    610                 615                 620                 


Phe Arg His Ile Phe Met Gly Arg Gly Asp His Thr Leu Gly Ala Leu 
625                 630                 635                 640 


Leu Asp His Leu Arg Leu Leu Arg Ser Asn Ser Ser Gly Thr Pro Gly 
                645                 650                 655     


Ala Thr Ser Ser Thr Gly Phe Gln Glu Ser Arg Phe Arg Arg Gln Leu 
            660                 665                 670         


Ala Leu Leu Thr Trp Thr Leu Gln Gly Ala Ala Asn Ala Leu Ser Gly 
        675                 680                 685             


Asp Val Trp Asn Ile Asp Asn Asn Phe 
    690                 695         


<210>  2
<211>  696
<212>  PRT
<213>  Mouse

<400>  2

Arg Gly Ser Cys Gln Ala Cys Gly Asp Ser Val Leu Val Val Asp Glu 
1               5                   10                  15      


Asp Val Asn Pro Glu Asp Ser Gly Arg Thr Thr Leu Tyr Trp Ser Asp 
            20                  25                  30          


Leu Gln Ala Met Phe Leu Arg Phe Leu Gly Glu Gly Arg Met Glu Asp 
        35                  40                  45              


Thr Ile Arg Leu Thr Ser Leu Arg Glu Arg Val Ala Gly Ser Ala Arg 
    50                  55                  60                  


Met Ala Thr Leu Val Gln Asp Ile Leu Asp Lys Leu Ser Arg Gln Lys 
65                  70                  75                  80  


Leu Asp His Val Trp Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro 
                85                  90                  95      


Asp Pro Ala His Ala Asn Thr Leu His Trp Val Asp Ala Asp Gly Ser 
            100                 105                 110         


Val Gln Glu Gln Leu Pro Leu Glu Asp Pro Glu Val Tyr Cys Pro Tyr 
        115                 120                 125             


Ser Ala Thr Gly Asn Ala Thr Gly Lys Leu Val Tyr Ala His Tyr Gly 
    130                 135                 140                 


Arg Ser Glu Asp Leu Gln Asp Leu Lys Ala Lys Gly Val Glu Leu Ala 
145                 150                 155                 160 


Gly Ser Leu Leu Leu Val Arg Val Gly Ile Thr Ser Phe Ala Gln Lys 
                165                 170                 175     


Val Ala Val Ala Gln Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro 
            180                 185                 190         


Asp Pro Ser Asp Phe Ser Gln Asp Pro His Lys Pro Gly Leu Ser Ser 
        195                 200                 205             


His Gln Ala Val Tyr Gly His Val His Leu Gly Thr Gly Asp Pro Tyr 
    210                 215                 220                 


Thr Pro Gly Phe Pro Ser Phe Asn Gln Thr Gln Phe Pro Pro Val Glu 
225                 230                 235                 240 


Ser Ser Gly Leu Pro Ser Ile Pro Ala Gln Pro Ile Ser Ala Asp Ile 
                245                 250                 255     


Ala Asp Gln Leu Leu Arg Lys Leu Thr Gly Pro Val Ala Pro Gln Glu 
            260                 265                 270         


Trp Lys Gly His Leu Ser Gly Ser Pro Tyr Arg Leu Gly Pro Gly Pro 
        275                 280                 285             


Asp Leu Arg Leu Val Val Asn Asn His Arg Val Ser Thr Pro Ile Ser 
    290                 295                 300                 


Asn Ile Phe Ala Cys Ile Glu Gly Phe Ala Glu Pro Asp His Tyr Val 
305                 310                 315                 320 


Val Ile Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser 
                325                 330                 335     


Ala Val Gly Thr Ala Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser 
            340                 345                 350         


Met Val Ser Asn Gly Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser 
        355                 360                 365             


Trp Asp Gly Gly Asp Phe Gly Ser Val Gly Ala Thr Glu Trp Leu Glu 
    370                 375                 380                 


Gly Tyr Leu Ser Val Leu His Leu Lys Ala Val Val Tyr Val Ser Leu 
385                 390                 395                 400 


Asp Asn Ser Val Leu Gly Asp Gly Lys Phe His Ala Lys Thr Ser Pro 
                405                 410                 415     


Leu Leu Val Ser Leu Ile Glu Asn Ile Leu Lys Gln Val Asp Ser Pro 
            420                 425                 430         


Asn His Ser Gly Gln Thr Leu Tyr Glu Gln Val Ala Leu Thr His Pro 
        435                 440                 445             


Ser Trp Asp Ala Glu Val Ile Gln Pro Leu Pro Met Asp Ser Ser Ala 
    450                 455                 460                 


Tyr Ser Phe Thr Ala Phe Ala Gly Val Pro Ala Val Glu Phe Ser Phe 
465                 470                 475                 480 


Met Glu Asp Asp Arg Val Tyr Pro Phe Leu His Thr Lys Glu Asp Thr 
                485                 490                 495     


Tyr Glu Asn Leu His Lys Met Leu Arg Gly Arg Leu Pro Ala Val Val 
            500                 505                 510         


Gln Ala Val Ala Gln Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His 
        515                 520                 525             


Asp His Leu Leu Pro Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu 
    530                 535                 540                 


Arg His Ile Gly Asn Leu Asn Glu Phe Ser Gly Asp Leu Lys Glu Arg 
545                 550                 555                 560 


Gly Leu Thr Leu Gln Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg 
                565                 570                 575     


Ala Ala Glu Lys Leu Arg Lys Glu Ile Tyr Ser Ser Glu Arg Asn Asp 
            580                 585                 590         


Glu Arg Leu Met Arg Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe 
        595                 600                 605             


Tyr Phe Leu Ser Gln Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His 
    610                 615                 620                 


Ile Phe Leu Gly Gln Gly Asp His Thr Leu Gly Ala Leu Val Asp His 
625                 630                 635                 640 


Leu Arg Met Leu Arg Ala Asp Gly Ser Gly Ala Ala Ser Ser Arg Leu 
                645                 650                 655     


Thr Ala Gly Leu Gly Phe Gln Glu Ser Arg Phe Arg Arg Gln Leu Ala 
            660                 665                 670         


Leu Leu Thr Trp Thr Leu Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
        675                 680                 685             


Val Trp Asn Ile Asp Asn Asn Phe 
    690                 695     


<210>  3
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Arg Leu Trp Gly Leu Phe Gln Arg Ala Gln Gln Leu Ser Pro 
1               5                   10                  15      


Arg Ser Ser Gln Thr Val Tyr Gln Arg Val Glu Gly Pro Arg Lys Gly 
            20                  25                  30          


His Leu Glu Glu Glu Glu Glu Asp Gly Glu Glu Gly Ala Glu Thr Leu 
        35                  40                  45              


Ala His Phe Cys Pro Met Glu Leu Arg Gly Pro Glu Pro Leu Gly Ser 
    50                  55                  60                  


Arg Pro Arg Gln Pro Asn Leu Ile Pro Trp Ala Ala Ala Gly Arg Arg 
65                  70                  75                  80  


Ala Ala Pro Tyr Leu Val Leu Thr Ala Leu Leu Ile Phe Thr Gly Ala 
                85                  90                  95      


Phe Leu Leu Gly Tyr Val Ala Phe Arg Gly Ser Cys Gln Ala Cys Gly 
            100                 105                 110         


Asp Ser Val Leu Val Val Ser Glu Asp Val Asn Tyr Glu Pro Asp Leu 
        115                 120                 125             


Asp Phe His Gln Gly Arg Leu Tyr Trp Ser Asp Leu Gln Ala Met Phe 
    130                 135                 140                 


Leu Gln Phe Leu Gly Glu Gly Arg Leu Glu Asp Thr Ile Arg Gln Thr 
145                 150                 155                 160 


Ser Leu Arg Glu Arg Val Ala Gly Ser Ala Gly Met Ala Ala Leu Thr 
                165                 170                 175     


Gln Asp Ile Arg Ala Ala Leu Ser Arg Gln Lys Leu Asp His Val Trp 
            180                 185                 190         


Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro Asp Pro Ala His Pro 
        195                 200                 205             


Asn Thr Leu His Trp Val Asp Glu Ala Gly Lys Val Gly Glu Gln Leu 
    210                 215                 220                 


Pro Leu Glu Asp Pro Asp Val Tyr Cys Pro Tyr Ser Ala Ile Gly Asn 
225                 230                 235                 240 


Val Thr Gly Glu Leu Val Tyr Ala His Tyr Gly Arg Pro Glu Asp Leu 
                245                 250                 255     


Gln Asp Leu Arg Ala Arg Gly Val Asp Pro Val Gly Arg Leu Leu Leu 
            260                 265                 270         


Val Arg Val Gly Val Ile Ser Phe Ala Gln Lys Val Thr Asn Ala Gln 
        275                 280                 285             


Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro Glu Pro Ala Asp Phe 
    290                 295                 300                 


Ser Gln Asp Pro Pro Lys Pro Ser Leu Ser Ser Gln Gln Ala Val Tyr 
305                 310                 315                 320 


Gly His Val His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro 
                325                 330                 335     


Ser Phe Asn Gln Thr Gln Phe Pro Pro Val Ala Ser Ser Gly Leu Pro 
            340                 345                 350         


Ser Ile Pro Ala Gln Pro Ile Ser Ala Asp Ile Ala Ser Arg Leu Leu 
        355                 360                 365             


Arg Lys Leu Lys Gly Pro Val Ala Pro Gln Glu Trp Gln Gly Ser Leu 
    370                 375                 380                 


Leu Gly Ser Pro Tyr His Leu Gly Pro Gly Pro Arg Leu Arg Leu Val 
385                 390                 395                 400 


Val Asn Asn His Arg Thr Ser Thr Pro Ile Asn Asn Ile Phe Gly Cys 
                405                 410                 415     


Ile Glu Gly Arg Ser Glu Pro Asp His Tyr Val Val Ile Gly Ala Gln 
            420                 425                 430         


Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser Ala Val Gly Thr Ala 
        435                 440                 445             


Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser Met Val Ser Asn Gly 
    450                 455                 460                 


Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser Trp Asp Gly Gly Asp 
465                 470                 475                 480 


Phe Gly Ser Val Gly Ser Thr Glu Trp Leu Glu Gly Tyr Leu Ser Val 
                485                 490                 495     


Leu His Leu Lys Ala Val Val Tyr Val Ser Leu Asp Asn Ala Val Leu 
            500                 505                 510         


Gly Asp Asp Lys Phe His Ala Lys Thr Ser Pro Leu Leu Thr Ser Leu 
        515                 520                 525             


Ile Glu Ser Val Leu Lys Gln Val Asp Ser Pro Asn His Ser Gly Gln 
    530                 535                 540                 


Thr Leu Tyr Glu Gln Val Val Phe Thr Asn Pro Ser Trp Asp Ala Glu 
545                 550                 555                 560 


Val Ile Arg Pro Leu Pro Met Asp Ser Ser Ala Tyr Ser Phe Thr Ala 
                565                 570                 575     


Phe Val Gly Val Pro Ala Val Glu Phe Ser Phe Met Glu Asp Asp Gln 
            580                 585                 590         


Ala Tyr Pro Phe Leu His Thr Lys Glu Asp Thr Tyr Glu Asn Leu His 
        595                 600                 605             


Lys Val Leu Gln Gly Arg Leu Pro Ala Val Ala Gln Ala Val Ala Gln 
    610                 615                 620                 


Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His Asp Arg Leu Leu Pro 
625                 630                 635                 640 


Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu Arg His Ile Gly Asn 
                645                 650                 655     


Leu Asn Glu Phe Ser Gly Asp Leu Lys Ala Arg Gly Leu Thr Leu Gln 
            660                 665                 670         


Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg Ala Ala Glu Lys Leu 
        675                 680                 685             


Arg Gln Glu Ile Tyr Ser Ser Glu Glu Arg Asp Glu Arg Leu Thr Arg 
    690                 695                 700                 


Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe Tyr Phe Leu Ser Gln 
705                 710                 715                 720 


Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His Ile Phe Met Gly Arg 
                725                 730                 735     


Gly Asp His Thr Leu Gly Ala Leu Leu Asp His Leu Arg Leu Leu Arg 
            740                 745                 750         


Ser Asn Ser Ser Gly Thr Pro Gly Ala Thr Ser Ser Thr Gly Phe Gln 
        755                 760                 765             


Glu Ser Arg Phe Arg Arg Gln Leu Ala Leu Leu Thr Trp Thr Leu Gln 
    770                 775                 780                 


Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp Asn Ile Asp Asn Asn 
785                 790                 795                 800 


Phe 
    


<210>  4
<211>  798
<212>  PRT
<213>  Mouse

<400>  4

Met Glu Gln Arg Trp Gly Leu Leu Arg Arg Val Gln Gln Trp Ser Pro 
1               5                   10                  15      


Arg Pro Ser Gln Thr Ile Tyr Arg Arg Val Glu Gly Pro Gln Leu Glu 
            20                  25                  30          


His Leu Glu Glu Glu Asp Arg Glu Glu Gly Ala Glu Leu Pro Ala Gln 
        35                  40                  45              


Phe Cys Pro Met Glu Leu Lys Gly Pro Glu His Leu Gly Ser Cys Pro 
    50                  55                  60                  


Gly Arg Ser Ile Pro Ile Pro Trp Ala Ala Ala Gly Arg Lys Ala Ala 
65                  70                  75                  80  


Pro Tyr Leu Val Leu Ile Thr Leu Leu Ile Phe Thr Gly Ala Phe Leu 
                85                  90                  95      


Leu Gly Tyr Val Ala Phe Arg Gly Ser Cys Gln Ala Cys Gly Asp Ser 
            100                 105                 110         


Val Leu Val Val Asp Glu Asp Val Asn Pro Glu Asp Ser Gly Arg Thr 
        115                 120                 125             


Thr Leu Tyr Trp Ser Asp Leu Gln Ala Met Phe Leu Arg Phe Leu Gly 
    130                 135                 140                 


Glu Gly Arg Met Glu Asp Thr Ile Arg Leu Thr Ser Leu Arg Glu Arg 
145                 150                 155                 160 


Val Ala Gly Ser Ala Arg Met Ala Thr Leu Val Gln Asp Ile Leu Asp 
                165                 170                 175     


Lys Leu Ser Arg Gln Lys Leu Asp His Val Trp Thr Asp Thr His Tyr 
            180                 185                 190         


Val Gly Leu Gln Phe Pro Asp Pro Ala His Ala Asn Thr Leu His Trp 
        195                 200                 205             


Val Asp Ala Asp Gly Ser Val Gln Glu Gln Leu Pro Leu Glu Asp Pro 
    210                 215                 220                 


Glu Val Tyr Cys Pro Tyr Ser Ala Thr Gly Asn Ala Thr Gly Lys Leu 
225                 230                 235                 240 


Val Tyr Ala His Tyr Gly Arg Ser Glu Asp Leu Gln Asp Leu Lys Ala 
                245                 250                 255     


Lys Gly Val Glu Leu Ala Gly Ser Leu Leu Leu Val Arg Val Gly Ile 
            260                 265                 270         


Thr Ser Phe Ala Gln Lys Val Ala Val Ala Gln Asp Phe Gly Ala Gln 
        275                 280                 285             


Gly Val Leu Ile Tyr Pro Asp Pro Ser Asp Phe Ser Gln Asp Pro His 
    290                 295                 300                 


Lys Pro Gly Leu Ser Ser His Gln Ala Val Tyr Gly His Val His Leu 
305                 310                 315                 320 


Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn Gln Thr 
                325                 330                 335     


Gln Phe Pro Pro Val Glu Ser Ser Gly Leu Pro Ser Ile Pro Ala Gln 
            340                 345                 350         


Pro Ile Ser Ala Asp Ile Ala Asp Gln Leu Leu Arg Lys Leu Thr Gly 
        355                 360                 365             


Pro Val Ala Pro Gln Glu Trp Lys Gly His Leu Ser Gly Ser Pro Tyr 
    370                 375                 380                 


Arg Leu Gly Pro Gly Pro Asp Leu Arg Leu Val Val Asn Asn His Arg 
385                 390                 395                 400 


Val Ser Thr Pro Ile Ser Asn Ile Phe Ala Cys Ile Glu Gly Phe Ala 
                405                 410                 415     


Glu Pro Asp His Tyr Val Val Ile Gly Ala Gln Arg Asp Ala Trp Gly 
            420                 425                 430         


Pro Gly Ala Ala Lys Ser Ala Val Gly Thr Ala Ile Leu Leu Glu Leu 
        435                 440                 445             


Val Arg Thr Phe Ser Ser Met Val Ser Asn Gly Phe Arg Pro Arg Arg 
    450                 455                 460                 


Ser Leu Leu Phe Ile Ser Trp Asp Gly Gly Asp Phe Gly Ser Val Gly 
465                 470                 475                 480 


Ala Thr Glu Trp Leu Glu Gly Tyr Leu Ser Val Leu His Leu Lys Ala 
                485                 490                 495     


Val Val Tyr Val Ser Leu Asp Asn Ser Val Leu Gly Asp Gly Lys Phe 
            500                 505                 510         


His Ala Lys Thr Ser Pro Leu Leu Val Ser Leu Ile Glu Asn Ile Leu 
        515                 520                 525             


Lys Gln Val Asp Ser Pro Asn His Ser Gly Gln Thr Leu Tyr Glu Gln 
    530                 535                 540                 


Val Ala Leu Thr His Pro Ser Trp Asp Ala Glu Val Ile Gln Pro Leu 
545                 550                 555                 560 


Pro Met Asp Ser Ser Ala Tyr Ser Phe Thr Ala Phe Ala Gly Val Pro 
                565                 570                 575     


Ala Val Glu Phe Ser Phe Met Glu Asp Asp Arg Val Tyr Pro Phe Leu 
            580                 585                 590         


His Thr Lys Glu Asp Thr Tyr Glu Asn Leu His Lys Met Leu Arg Gly 
        595                 600                 605             


Arg Leu Pro Ala Val Val Gln Ala Val Ala Gln Leu Ala Gly Gln Leu 
    610                 615                 620                 


Leu Ile Arg Leu Ser His Asp His Leu Leu Pro Leu Asp Phe Gly Arg 
625                 630                 635                 640 


Tyr Gly Asp Val Val Leu Arg His Ile Gly Asn Leu Asn Glu Phe Ser 
                645                 650                 655     


Gly Asp Leu Lys Glu Arg Gly Leu Thr Leu Gln Trp Val Tyr Ser Ala 
            660                 665                 670         


Arg Gly Asp Tyr Ile Arg Ala Ala Glu Lys Leu Arg Lys Glu Ile Tyr 
        675                 680                 685             


Ser Ser Glu Arg Asn Asp Glu Arg Leu Met Arg Met Tyr Asn Val Arg 
    690                 695                 700                 


Ile Met Arg Val Glu Phe Tyr Phe Leu Ser Gln Tyr Val Ser Pro Ala 
705                 710                 715                 720 


Asp Ser Pro Phe Arg His Ile Phe Leu Gly Gln Gly Asp His Thr Leu 
                725                 730                 735     


Gly Ala Leu Val Asp His Leu Arg Met Leu Arg Ala Asp Gly Ser Gly 
            740                 745                 750         


Ala Ala Ser Ser Arg Leu Thr Ala Gly Leu Gly Phe Gln Glu Ser Arg 
        755                 760                 765             


Phe Arg Arg Gln Leu Ala Leu Leu Thr Trp Thr Leu Gln Gly Ala Ala 
    770                 775                 780                 


Asn Ala Leu Ser Gly Asp Val Trp Asn Ile Asp Asn Asn Phe 
785                 790                 795             


<210>  5
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Cys Pro Tyr Ser Ala Ile Gly Asn Val Thr Gly Glu Leu Val Tyr 
1               5                   10                  15      


Ala His Tyr Gly Arg Pro Glu Asp Leu Gln Asp Leu Arg Ala Arg Gly 
            20                  25                  30          


Val Asp Pro Val Gly Arg Leu Leu Leu Val Arg Val Gly Val Ile Ser 
        35                  40                  45              


Phe Ala Gln Lys Val Thr Asn Ala Gln Asp Phe Gly Ala Gln Gly Val 
    50                  55                  60                  


Leu Ile Tyr Pro Glu Pro Ala Asp Phe Ser Gln Asp Pro Pro Lys Pro 
65                  70                  75                  80  


Ser Leu Ser Ser Gln Gln Ala Val Tyr Gly His Val His Leu 
                85                  90                  


<210>  6
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Arg Ser Glu Pro Asp His Tyr Val Val Ile Gly Ala Gln Arg Asp 
1               5                   10                  15      


Ala Trp Gly Pro Gly Ala Ala Lys Ser Ala Val Gly Thr Ala Ile Leu 
            20                  25                  30          


Leu Glu Leu Val Arg Thr Phe Ser Ser Met Val Ser Asn Gly Phe Arg 
        35                  40                  45              


Pro Arg Arg Ser Leu Leu Phe Ile Ser Trp Asp Gly Gly Asp Phe Gly 
    50                  55                  60                  


Ser Val Gly Ser Thr Glu Trp Leu Glu Gly Tyr Leu Ser Val Leu His 
65                  70                  75                  80  


Leu Lys Ala Val Val Tyr Val Ser Leu Asp Asn Ala Val Leu Gly Asp 
                85                  90                  95      


Asp Lys Phe His Ala Lys Thr Ser Pro Leu Leu Thr Ser Leu Ile Glu 
            100                 105                 110         


Ser Val Leu Lys Gln Val Asp Ser Pro Asn His Ser Gly Gln Thr Leu 
        115                 120                 125             


Tyr Glu Gln Val Val Phe Thr Asn Pro Ser Trp Asp Ala Glu Val Ile 
    130                 135                 140                 


Arg Pro Leu Pro Met Asp Ser Ser Ala Tyr Ser Phe Thr Ala Phe Val 
145                 150                 155                 160 


Gly Val Pro Ala Val Glu Phe Ser Phe Met Glu Asp Asp Gln Ala Tyr 
                165                 170                 175     


Pro Phe Leu His Thr Lys Glu Asp Thr Tyr 
            180                 185     


<210>  7
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Lys Ala Arg Gly Leu Thr Leu Gln Trp Val Tyr Ser Ala Arg Gly 
1               5                   10                  15      


Asp Tyr Ile Arg Ala Ala Glu Lys Leu Arg Gln Glu Ile Tyr Ser Ser 
            20                  25                  30          


Glu Glu Arg Asp Glu Arg Leu Thr Arg Met Tyr Asn Val Arg Ile Met 
        35                  40                  45              


Arg Val Glu Phe Tyr Phe Leu Ser Gln Tyr Val Ser Pro Ala Asp Ser 
    50                  55                  60                  


Pro Phe Arg His Ile Phe Met Gly Arg Gly Asp His Thr Leu Gly Ala 
65                  70                  75                  80  


Leu Leu Asp His Leu Arg Leu Leu Arg Ser Asn Ser Ser Gly Thr Pro 
                85                  90                  95      


Gly Ala Thr Ser Ser Thr Gly Phe Gln Glu Ser Arg Phe Arg Arg Gln 
            100                 105                 110         


Leu Ala Leu Leu Thr Trp Thr Leu Gln Gly Ala Ala Asn Ala 
        115                 120                 125     


<210>  8
<211>  2538
<212>  DNA
<213>  Homo sapiens

<400>  8
gttcgttgca acaaattgat gagcaatgct tttttataat gccaactttg tacaaaaaag       60

ttggcaccat ggagcggctt tggggtctat tccagagagc gcaacaactg tccccaagat      120

cctctcagac cgtctaccag cgtgtggaag gcccccggaa agggcacctg gaggaggaag      180

aggaagacgg ggaggagggg gcggagacat tggcccactt ctgccccatg gagctgaggg      240

gccctgagcc cctgggctct agacccaggc agccaaacct cattccctgg gcggcagcag      300

gacggagggc tgccccctac ctggtcctga cggccctgct gatcttcact ggggccttcc      360

tactgggcta cgtcgccttc cgagggtcct gccaggcgtg cggagactct gtgttggtgg      420

tcagtgagga tgtcaactat gagcctgacc tggatttcca ccagggcaga ctctactgga      480

gcgacctcca ggccatgttc ctgcagttcc tgggggaggg gcgcctggag gacaccatca      540

ggcaaaccag ccttcgggaa cgggtggcag gctcggccgg gatggccgct ctgactcagg      600

acattcgcgc ggcgctctcc cgccagaagc tggaccacgt gtggaccgac acgcactacg      660

tggggctgca attcccggat ccggctcacc ccaacaccct gcactgggtc gatgaggccg      720

ggaaggtcgg agagcagctg ccgctggagg accctgacgt ctactgcccc tacagcgcca      780

tcggcaacgt cacgggagag ctggtgtacg cccactacgg gcggcccgaa gacctgcagg      840

acctgcgggc caggggcgtg gatccagtgg gccgcctgct gctggtgcgc gtgggggtga      900

tcagcttcgc ccagaaggtg accaatgctc aggacttcgg ggctcaagga gtgctcatat      960

acccagagcc agcggacttc tcccaggacc cacccaagcc aagcctgtcc agccagcagg     1020

cagtgtatgg acatgtgcac ctgggaactg gagaccccta cacacctggc ttcccttcct     1080

tcaatcaaac ccagttccct ccagttgcat catcaggcct tcccagcatc ccagcccagc     1140

ccatcagtgc agacattgcc tcccgcctgc tgaggaagct caaaggccct gtggcccccc     1200

aagaatggca ggggagcctc ctaggctccc cttatcacct gggccccggg ccacgacttc     1260

ggctagtggt caacaatcac aggacctcca cccccatcaa caacatcttc ggctgcatcg     1320

aaggccgctc agagccagat cactacgttg tcatcggggc ccagagggat gcatggggcc     1380

caggagcagc taaatccgct gtggggacgg ctatactcct ggagctggtg cggacctttt     1440

cctccatggt gagcaacggc ttccggcccc gcagaagtct cctcttcatc agctgggacg     1500

gtggtgactt tggaagcgtg ggctccacgg agtggctaga gggctacctc agcgtgctgc     1560

acctcaaagc cgtagtgtac gtgagcctgg acaacgcagt gctgggggat gacaagtttc     1620

atgccaagac cagccccctt ctgacaagtc tcattgagag tgtcctgaag caggtggatt     1680

ctcccaacca cagtgggcag actctctatg aacaggtggt gttcaccaat cccagctggg     1740

atgctgaggt gatccggccc ctacccatgg acagcagtgc ctattccttc acggcctttg     1800

tgggagtccc tgccgtcgag ttctccttta tggaggacga ccaggcctac ccattcctgc     1860

acacaaagga ggacacttat gagaacctgc ataaggtgct gcaaggccgc ctgcccgccg     1920

tggcccaggc cgtggcccag ctcgcagggc agctcctcat ccggctcagc cacgatcgcc     1980

tgctgcccct cgacttcggc cgctacgggg acgtcgtcct caggcacatc gggaacctca     2040

acgagttctc tggggacctc aaggcccgcg ggctgaccct gcagtgggtg tactcggcgc     2100

ggggggacta catccgggcg gcggaaaagc tgcggccgga gatctacagc tcggaggaga     2160

gagacgagcg actgacacgc atgtacaacg tgcgcataat gcgggtggag ttctacttcc     2220

tttcccagta cgtgtcgcca gccgactccc cgttccgcca catcttcatg ggccgtggag     2280

accacacgct gggcgccctg ctggaccacc tgcggctgct gcgctccaac agctccggga     2340

cccccggggc cacctcctcc actggcttcc aggagagccg tttccggcgt cagctagccc     2400

tgctcacctg gacgctgcaa ggggcagcca atgcgcttag cggggatgtc tggaacattg     2460

ataacaactt cttgccaact ttcttgtaca aagttggcat tataagaaag cattgcttat     2520

caatttgttg caacgaac                                                   2538


<210>  9
<211>  3597
<212>  DNA
<213>  Mouse

<400>  9
gagtctcctg ggagcatggt ccaagaaacc cagagacctg ttgctgagct gaacttggct       60

gctgtgtctt cccactcagg actcggcttt gacaggcacg aggcagggac tggggtactg      120

gtgagcccct acctctcaga tctttctgga cctggctgca ggtcctggtg tcttcgtcgc      180

ggcttggatt tcaaactgga ggagttcagg agggggcaca agcatggagc aacgttgggg      240

tctacttcgg agagtgcaac agtggtcccc aagaccctct cagaccatct acagacgcgt      300

ggaaggccct cagctggagc acctggagga ggaagacagg gaggaagggg cggagcttcc      360

tgcccagttc tgccccatgg aactcaaagg ccctgagcac ttaggctcct gtcccgggag      420

gtcaattccc ataccctggg ctgcagcagg tcgaaaggct gccccctatc tggtcctgat      480

caccctgcta atcttcactg gggccttcct cctaggctac gtggcctttc gagggtcctg      540

ccaggcgtgt ggggactccg tgttggtggt cgatgaagat gtcaaccctg aggactccgg      600

ccggaccacg ttgtactgga gcgacctcca ggccatgttt ctccggttcc ttggggaggg      660

gcgcatggaa gacaccatca ggctgaccag cctccgggaa cgcgtggctg gctcagccag      720

aatggccacc ctggtccaag atatcctcga taagctctcg cgccagaagc tggaccacgt      780

gtggactgac acgcactacg tgggacttca gttcccagat ccggctcacg ctaacaccct      840

gcactgggtg gatgcagacg ggagcgtcca ggagcagcta ccgctggagg atccggaagt      900

ctactgtccc tacagcgcca ccggcaacgc cacgggcaag ctggtgtacg cccactacgg      960

gcggtcggag gacctacagg acctaaaagc caagggcgtg gagctggccg gcagcctcct     1020

gctagtgcga gttggaatta ctagcttcgc ccagaaggta gccgttgccc aggactttgg     1080

ggctcaagga gtgctgatat accctgaccc atcagacttc tcccaggatc cccacaagcc     1140

aggcctgtct agccaccagg ctgtgtacgg acatgtgcac ctgggaactg gagaccctta     1200

cacacctggc ttcccgtcct tcaatcaaac ccagttccct ccagtagaat catcaggcct     1260

tcccagcatc cccgcccagc ccatcagtgc tgacattgct gatcaattgc tcaggaaact     1320

cacaggcccc gtggctcccc aggagtggaa aggtcacctc tcaggctctc cttatcggct     1380

gggacctggg cccgacttac gccttgtggt caacaaccac agagtctcta cccccatcag     1440

taacatcttt gcgtgcatcg agggctttgc agagccagat cactatgttg tcattggggc     1500

ccagagggat gcatggggcc caggagcagc caagtctgca gtggggactg ccatcctgct     1560

ggagctggtt cggaccttct cttccatggt cagcaatggg ttcagacctc gaagaagtct     1620

tttgttcatc agctgggacg gaggtgactt tggcagcgtg ggagccacag agtggttgga     1680

gggctacctc agcgtgctac acctcaaagc tgttgtgtac gtgagcctgg acaactccgt     1740

gttgggagat ggcaaattcc atgctaagac cagccccctt ctcgtcagcc tcattgagaa     1800

tatcttgaag caggtggact cccctaacca tagtggacag accctctatg aacaagtggc     1860

actcacccac cccagctggg atgctgaagt gattcagccc ctgcccatgg acagcagtgc     1920

atattccttc acagcctttg cgggggtccc agctgtggag ttctccttca tggaggatga     1980

tcgggtgtac ccattcctgc acacgaagga ggacacatat gagaatctgc acaagatgct     2040

gcgaggtcgc ctgcccgccg tggtccaggc agtggctcag ctcgcgggcc agctcctcat     2100

ccgactgagc cacgatcacc tactgccgct agacttcggc cgctatggag acgtggttct     2160

caggcacatc ggcaacctca atgagttctc tggggacctc aaggagcgcg ggctgaccct     2220

gcagtgggtg tactctgcaa ggggggacta catccgtgcg gcggaaaagc tgcggaagga     2280

gatttacagc tcggagcgga acgatgagcg tctgatgcgc atgtacaacg tgcgcatcat     2340

gagggtggag ttctacttcc tgtcccagta tgtgtcgcca gccgactccc cattccgcca     2400

cattttccta ggccaaggcg accacacttt gggtgccctg gtagaccacc tgcggatgct     2460

gcgcgccgat ggctcaggag ccgcctcttc ccggttgaca gcaggtctgg gcttccagga     2520

gagtcgcttc cggcgccagc tggcgctgct cacctggaca ctgcaggggg cagccaacgc     2580

tctcagtggc gacgtttgga acattgacaa taacttttga agccaaaagc cctccatggg     2640

ccccacgtga ttctcctttc tccctctttg agtggtgcag gcaaaggagg tgcctgagat     2700

tgtaacctat tcttaacacc cttggtcctg caatgctggt gcgccatatt ttctcagtgt     2760

ggttgtcatg ccgttgctta cccagaaagc ggttttcttc ccatcacagg cccttctgtc     2820

ttcaggagca aagttcccca tatctagaga ctatctagat gctgggatct gatcagctct     2880

cttagagagt gagatggaca gcgtcattat tttatgacac atgagctacg gtatgtgagc     2940

agcccaaggg gattagatgt caataaacca attgtaaccc ctgttgtcca tacgcaattt     3000

agcttcctct tcatgccgta cccactcctc atatccgcct tgagactagg gaagaaggca     3060

cagaaggcac ctgacagcat gcttgcaaga tgctatccac atgggaaaaa taactgttct     3120

gatgtctaag aaaactgcct aaagataatg gataggaggt ggggcagtgg ggataactca     3180

tcaggaatgg gtgattgcgg ccaagcctga tgacctgagt ttaatcccca ggaccaacat     3240

ggcaaaagga gagaactagt tcccacaagt tttcctatat cctccaaatg tatgcccata     3300

aaagcacaaa tagataaatg tttttgcttt tgttttttaa agtggctttg tggttaagag     3360

cactggatgc cattctagaa gacaccggtt cgattcccag cacccacatg gccgcttaca     3420

actgtctgta actccagttg ctggggatca gatgccctct tctggtatgg tgtacgactg     3480

catgcatgta gtatacatac aagcaggcaa aatacccata catgtaaaat ttttaaaaaa     3540

tagtttaaat tataaattaa tttaaagaac aaataaaaga ttaatgcctt taatccc        3597


