                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Kyratsous, Christos
       Murphy, Andrew J
       Wang, Cheng
       Sabin, Leah
 
<120>  Tropism-Modified Recombinant Viral Vectors and Uses Thereof for 
       the Targeted Introduction of Genetic Material into Human Cell

<130>  009108.335WO1/10335WO01

<150>  62/525,704
<151>  2017-06-27

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  735
<212>  PRT
<213>  adeno-associated virus 2

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  2
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2 VP1 N587Myc

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Glu Gln Lys Leu Ile 
            580                 585                 590         


Ser Glu Glu Asp Leu Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln 
        595                 600                 605             


Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln 
    610                 615                 620                 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro 
625                 630                 635                 640 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
                645                 650                 655     


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser 
            660                 665                 670         


Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
        675                 680                 685             


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
    690                 695                 700                 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val 
705                 710                 715                 720 


Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile 
                725                 730                 735     


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745 


<210>  3
<211>  736
<212>  PRT
<213>  adeno-associated virus 6

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  4
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV6 VP1 Q585Myc

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Glu Gln Lys Leu Ile Ser Glu 
            580                 585                 590         


Glu Asp Leu Ser Ser Ser Thr Asp Pro Ala Thr Gly Asp Val His Val 
        595                 600                 605             


Met Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu 
    610                 615                 620                 


Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His 
625                 630                 635                 640 


Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln 
                645                 650                 655     


Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Ala Glu Phe 
            660                 665                 670         


Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
        675                 680                 685             


Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg 
    690                 695                 700                 


Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn 
705                 710                 715                 720 


Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro 
                725                 730                 735     


Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
            740                 745     


<210>  5
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  5

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-myc

<400>  6

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG

<400>  7

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA

<400>  8

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fwd ITR primer

<400>  9
ggaaccccta gtgatggagt t                                                 21


<210>  10
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rvs ITR primer

<400>  10
cggcctcagt gagcga                                                       16


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 ITRs probe

<400>  11
cactccctct ctgcgcgctc g                                                 21


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-myc

<400>  12
gaacaaaaac tcatctcaga agaggatctg                                        30


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAVRCBsiWF

<400>  13
ggagtaccag ctcccgtacg                                                   20


<210>  14
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N587mycR

<400>  14
ctcttctgag atgagttttt gttcgttgcc tctctggagg ttg                         43


<210>  15
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N587mycF

<400>  15
aaactcatct cagaagagga tctgagacaa gcagctaccg cag                         43


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAVRCPmeR

<400>  16
tccgcccgct gtttaaac                                                     18


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAVRC9BsiWF

<400>  17
actcagacta tcagctcccg tacg                                              24


<210>  18
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A589mycR

<400>  18
ctcttctgag atgagttttt gttctgcttg ggcactctgg t                           41


<210>  19
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A589mycF

<400>  19
aaactcatct cagagaggat ctgcaggcgc agaccgg                                37


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAVRC9PmeR

<400>  20
ctccgcccgc tgtttaaac                                                    19


<210>  21
<211>  738
<212>  PRT
<213>  adeno-associated virus 8

<400>  21

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  22
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV8 N590myc gblock

<400>  22
gaccctgtta ccgccaacaa cgcgtctcaa cgacaaccgg gcaaaacaac aatagcaact       60

ttgcctggac tgctgggacc aaataccatc tgaatggaag aaattcattg gctaatcctg      120

gcatcgctat ggcaacacac aaagacgacg aggagcgttt ttttcccagt aacgggatcc      180

tgatttttgg caaacaaaat gctgccagag acaatgcgga ttacagcgat gtcatgctca      240

ccagcgagga agaaatcaaa accactaacc ctgtggctac agaggaatac ggtatcgtgg      300

cagataactt gcagcagcaa aacgaacaaa aactcatctc agaagaggat ctgacggctc      360

ctcaaattgg aactgtcaac agccaggggg ccttacccgg tatggtctgg cagaaccggg      420

acgtgtacct gcagggtccc atctgggcca aga                                   453


<210>  23
<211>  7336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV RC2/8

<400>  23
gcgcgccgat atcgttaacg ccccgcgccg gccgctctag aactagtgga tcccccggaa       60

gatcagaagt tcctattccg aagttcctat tctctagaaa gtataggaac ttctgatctg      120

cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga      180

gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt      240

gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga      300

gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggccct      360

tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac      420

caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat      480

tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac      540

cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt      600

gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag      660

cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc      720

gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag      780

atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac      840

ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc      900

caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac      960

taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg     1020

gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct     1080

gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac     1140

taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt     1200

aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg     1260

ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag     1320

caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat     1380

cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca     1440

ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga     1500

ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt     1560

ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc     1620

cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac     1680

gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca     1740

cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc     1800

aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc     1860

tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat     1920

gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg     1980

catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat cttccagatt     2040

ggctcgagga caacctctct gagggcattc gcgagtggtg ggcgctgaaa cctggagccc     2100

cgaagcccaa agccaaccag caaaagcagg acgacggccg gggtctggtg cttcctggct     2160

acaagtacct cggacccttc aacggactcg acaaggggga gcccgtcaac gcggcggacg     2220

cagcggccct cgagcacgac aaggcctacg accagcagct gcaggcgggt gacaatccgt     2280

acctgcggta taaccacgcc gacgccgagt ttcaggagcg tctgcaagaa gatacgtctt     2340

ttgggggcaa cctcgggcga gcagtcttcc aggccaagaa gcgggttctc gaacctctcg     2400

gtctggttga ggaaggcgct aagacggctc ctggaaagaa gagaccggta gagccatcac     2460

cccagcgttc tccagactcc tctacgggca tcggcaagaa aggccaacag cccgccagaa     2520

aaagactcaa ttttggtcag actggcgact cagagtcagt tccagaccct caacctctcg     2580

gagaacctcc agcagcgccc tctggtgtgg gacctaatac aatggctgca ggcggtggcg     2640

caccaatggc agacaataac gaaggcgccg acggagtggg tagttcctcg ggaaattggc     2700

attgcgattc cacatggctg ggcgacagag tcatcaccac cagcacccga acctgggccc     2760

tgcccaccta caacaaccac ctctacaagc aaatctccaa cgggacatcg ggaggagcca     2820

ccaacgacaa cacctacttc ggctacagca ccccctgggg gtattttgac tttaacagat     2880

tccactgcca cttttcacca cgtgactggc agcgactcat caacaacaac tggggattcc     2940

ggcccaagag actcagcttc aagctcttca acatccaggt caaggaggtc acgcagaatg     3000

aaggcaccaa gaccatcgcc aataacctca ccagcaccat ccaggtgttt acggactcgg     3060

agtaccagct gccgtacgtt ctcggctctg cccaccaggg ctgcctgcct ccgttcccgg     3120

cggacgtgtt catgattccc cagtacggct acctaacact caacaacggt agtcaggccg     3180

tgggacgctc ctccttctac tgcctggaat actttccttc gcagatgctg agaaccggca     3240

acaacttcca gtttacttac accttcgagg acgtgccttt ccacagcagc tacgcccaca     3300

gccagagctt ggaccggctg atgaatcctc tgattgacca gtacctgtac tacttgtctc     3360

ggactcaaac aacaggaggc acggcaaata cgcagactct gggcttcagc caaggtgggc     3420

ctaatacaat ggccaatcag gcaaagaact ggctgccagg accctgttac cgccaacaac     3480

gcgtctcaac gacaaccggg caaaacaaca atagcaactt tgcctggact gctgggacca     3540

aataccatct gaatggaaga aattcattgg ctaatcctgg catcgctatg gcaacacaca     3600

aagacgacga ggagcgtttt tttcccagta acgggatcct gatttttggc aaacaaaatg     3660

ctgccagaga caatgcggat tacagcgatg tcatgctcac cagcgaggaa gaaatcaaaa     3720

ccactaaccc tgtggctaca gaggaatacg gtatcgtggc agataacttg cagcagcaaa     3780

acacggctcc tcaaattgga actgtcaaca gccagggggc cttacccggt atggtctggc     3840

agaaccggga cgtgtacctg cagggtccca tctgggccaa gattcctcac acggacggca     3900

acttccaccc gtctccgctg atgggcggct ttggcctgaa acatcctccg cctcagatcc     3960

tgatcaagaa cacgcctgta cctgcggatc ctccgaccac cttcaaccag tcaaagctga     4020

actctttcat cacgcaatac agcaccggac aggtcagcgt ggaaattgaa tgggagctgc     4080

agaaggaaaa cagcaagcgc tggaaccccg agatccagta cacctccaac tactacaaat     4140

ctacaagtgt ggactttgct gttaatacag aaggcgtgta ctctgaaccc cgccccattg     4200

gcacccgtta cctcacccgt aatctgtaat tgcctgttaa tcaataaacc gtttaattcg     4260

tttcagttga actttggtct ctgcgtattt ctttcttatc tagtttccat ggctacgtag     4320

ataagtagca tggcgggtta atcattaact acagcccggg cgtttaaaca gcgggcggag     4380

gggtggagtc gtgacgtgaa ttacgtcata gggttaggga ggtcctgtat tagaggtcac     4440

gtgagtgttt tgcgacattt tgcgacacca tgtggtctcg ctgggggggg gggcccgagt     4500

gagcacgcag ggtctccatt ttgaagcggg aggtttgaac gagcgctggc gcgctcactg     4560

gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt     4620

gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct     4680

tcccaacagt tgcgcagcct gaatggcgaa tggaaattgt aagcgttaat attttgttaa     4740

aattcgcgtt aaatttttgt taaatcagct cattttttta accaataggc cgaaatcggc     4800

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     4860

aacaagagtc cactattaag aacgtggact ccaacgtcaa agggcgaaaa accgtctatc     4920

agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc     4980

gtaaagcact aaatcggaac cctaaaggga gcccccgatt tagagcttga cggggaaagc     5040

cggcgaacgt ggcgagaaag gaagggaaga aagcgaaagg agcgggcgct agggcgctgg     5100

caagtgtagc ggtcacgctg cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac     5160

agggcgcgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     5220

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     5280

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     5340

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     5400

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     5460

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     5520

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     5580

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     5640

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     5700

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     5760

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     5820

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     5880

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     5940

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     6000

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     6060

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     6120

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     6180

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     6240

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     6300

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     6360

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     6420

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc     6480

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     6540

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     6600

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     6660

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     6720

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     6780

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     6840

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     6900

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     6960

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     7020

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     7080

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     7140

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca     7200

acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc     7260

cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg     7320

accatgatta cgccaa                                                     7336


<210>  24
<211>  7366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   paav RC2/8 myc plasmid

<400>  24
gcgcgccgat atcgttaacg ccccgcgccg gccgctctag aactagtgga tcccccggaa       60

gatcagaagt tcctattccg aagttcctat tctctagaaa gtataggaac ttctgatctg      120

cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga      180

gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt      240

gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga      300

gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggccct      360

tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac      420

caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat      480

tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac      540

cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt      600

gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag      660

cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc      720

gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag      780

atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac      840

ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc      900

caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac      960

taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg     1020

gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct     1080

gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac     1140

taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt     1200

aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg     1260

ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag     1320

caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat     1380

cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca     1440

ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga     1500

ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt     1560

ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc     1620

cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac     1680

gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca     1740

cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc     1800

aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc     1860

tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat     1920

gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg     1980

catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat cttccagatt     2040

ggctcgagga caacctctct gagggcattc gcgagtggtg ggcgctgaaa cctggagccc     2100

cgaagcccaa agccaaccag caaaagcagg acgacggccg gggtctggtg cttcctggct     2160

acaagtacct cggacccttc aacggactcg acaaggggga gcccgtcaac gcggcggacg     2220

cagcggccct cgagcacgac aaggcctacg accagcagct gcaggcgggt gacaatccgt     2280

acctgcggta taaccacgcc gacgccgagt ttcaggagcg tctgcaagaa gatacgtctt     2340

ttgggggcaa cctcgggcga gcagtcttcc aggccaagaa gcgggttctc gaacctctcg     2400

gtctggttga ggaaggcgct aagacggctc ctggaaagaa gagaccggta gagccatcac     2460

cccagcgttc tccagactcc tctacgggca tcggcaagaa aggccaacag cccgccagaa     2520

aaagactcaa ttttggtcag actggcgact cagagtcagt tccagaccct caacctctcg     2580

gagaacctcc agcagcgccc tctggtgtgg gacctaatac aatggctgca ggcggtggcg     2640

caccaatggc agacaataac gaaggcgccg acggagtggg tagttcctcg ggaaattggc     2700

attgcgattc cacatggctg ggcgacagag tcatcaccac cagcacccga acctgggccc     2760

tgcccaccta caacaaccac ctctacaagc aaatctccaa cgggacatcg ggaggagcca     2820

ccaacgacaa cacctacttc ggctacagca ccccctgggg gtattttgac tttaacagat     2880

tccactgcca cttttcacca cgtgactggc agcgactcat caacaacaac tggggattcc     2940

ggcccaagag actcagcttc aagctcttca acatccaggt caaggaggtc acgcagaatg     3000

aaggcaccaa gaccatcgcc aataacctca ccagcaccat ccaggtgttt acggactcgg     3060

agtaccagct gccgtacgtt ctcggctctg cccaccaggg ctgcctgcct ccgttcccgg     3120

cggacgtgtt catgattccc cagtacggct acctaacact caacaacggt agtcaggccg     3180

tgggacgctc ctccttctac tgcctggaat actttccttc gcagatgctg agaaccggca     3240

acaacttcca gtttacttac accttcgagg acgtgccttt ccacagcagc tacgcccaca     3300

gccagagctt ggaccggctg atgaatcctc tgattgacca gtacctgtac tacttgtctc     3360

ggactcaaac aacaggaggc acggcaaata cgcagactct gggcttcagc caaggtgggc     3420

ctaatacaat ggccaatcag gcaaagaact ggctgccagg accctgttac cgccaacaac     3480

gcgtctcaac gacaaccggg caaaacaaca atagcaactt tgcctggact gctgggacca     3540

aataccatct gaatggaaga aattcattgg ctaatcctgg catcgctatg gcaacacaca     3600

aagacgacga ggagcgtttt tttcccagta acgggatcct gatttttggc aaacaaaatg     3660

ctgccagaga caatgcggat tacagcgatg tcatgctcac cagcgaggaa gaaatcaaaa     3720

ccactaaccc tgtggctaca gaggaatacg gtatcgtggc agataacttg cagcagcaaa     3780

acgaacaaaa actcatctca gaagaggatc tgacggctcc tcaaattgga actgtcaaca     3840

gccagggggc cttacccggt atggtctggc agaaccggga cgtgtacctg cagggtccca     3900

tctgggccaa gattcctcac acggacggca acttccaccc gtctccgctg atgggcggct     3960

ttggcctgaa acatcctccg cctcagatcc tgatcaagaa cacgcctgta cctgcggatc     4020

ctccgaccac cttcaaccag tcaaagctga actctttcat cacgcaatac agcaccggac     4080

aggtcagcgt ggaaattgaa tgggagctgc agaaggaaaa cagcaagcgc tggaaccccg     4140

agatccagta cacctccaac tactacaaat ctacaagtgt ggactttgct gttaatacag     4200

aaggcgtgta ctctgaaccc cgccccattg gcacccgtta cctcacccgt aatctgtaat     4260

tgcctgttaa tcaataaacc gtttaattcg tttcagttga actttggtct ctgcgtattt     4320

ctttcttatc tagtttccat ggctacgtag ataagtagca tggcgggtta atcattaact     4380

acagcccggg cgtttaaaca gcgggcggag gggtggagtc gtgacgtgaa ttacgtcata     4440

gggttaggga ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca     4500

tgtggtctcg ctgggggggg gggcccgagt gagcacgcag ggtctccatt ttgaagcggg     4560

aggtttgaac gagcgctggc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa     4620

aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt     4680

aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa     4740

tggaaattgt aagcgttaat attttgttaa aattcgcgtt aaatttttgt taaatcagct     4800

cattttttta accaataggc cgaaatcggc aaaatccctt ataaatcaaa agaatagacc     4860

gagatagggt tgagtgttgt tccagtttgg aacaagagtc cactattaag aacgtggact     4920

ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt gaaccatcac     4980

cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga     5040

gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga     5100

aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca     5160

ccacacccgc cgcgcttaat gcgccgctac agggcgcgtc aggtggcact tttcggggaa     5220

atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca     5280

tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc     5340

aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc     5400

acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt     5460

acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt     5520

ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg     5580

ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact     5640

caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg     5700

ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga     5760

aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg     5820

aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa     5880

tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac     5940

aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc     6000

cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca     6060

ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga     6120

gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta     6180

agcattggta actgtcagac caagtttact catatatact ttagattgat ttaaaacttc     6240

atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     6300

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     6360

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     6420

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     6480

tcagcagagc gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact     6540

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     6600

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     6660

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     6720

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     6780

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     6840

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     6900

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     6960

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg     7020

cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc     7080

gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa     7140

tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt     7200

ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt     7260

aggcacccca ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg     7320

gataacaatt tcacacagga aacagctatg accatgatta cgccaa                    7366


<210>  25
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAAV8N590myc

<400>  25

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Glu Gln 
            580                 585                 590         


Lys Leu Ile Ser Glu Glu Asp Leu Thr Ala Pro Gln Ile Gly Thr Val 
        595                 600                 605             


Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val 
    610                 615                 620                 


Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn 
625                 630                 635                 640 


Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro 
                645                 650                 655     


Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr 
            660                 665                 670         


Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr 
        675                 680                 685             


Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser 
    690                 695                 700                 


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser 
705                 710                 715                 720 


Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro 
                725                 730                 735     


Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745             


<210>  26
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAAV9A589myc

<400>  26

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Glu Gln Lys 
            580                 585                 590         


Leu Ile Ser Glu Glu Asp Leu Gln Ala Gln Thr Gly Trp Val Gln Asn 
        595                 600                 605             


Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu 
    610                 615                 620                 


Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His 
625                 630                 635                 640 


Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln 
                645                 650                 655     


Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe 
            660                 665                 670         


Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
        675                 680                 685             


Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg 
    690                 695                 700                 


Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn 
705                 710                 715                 720 


Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro 
                725                 730                 735     


Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745     


<210>  27
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pAAV9G453myc

<400>  27

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser 
    450                 455                 460                 


Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn 
465                 470                 475                 480 


Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln 
                485                 490                 495     


Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala 
            500                 505                 510         


Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met 
        515                 520                 525             


Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe 
    530                 535                 540                 


Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg 
545                 550                 555                 560 


Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile 
                565                 570                 575     


Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr 
            580                 585                 590         


Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn 
        595                 600                 605             


Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu 
    610                 615                 620                 


Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His 
625                 630                 635                 640 


Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln 
                645                 650                 655     


Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe 
            660                 665                 670         


Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
        675                 680                 685             


Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg 
    690                 695                 700                 


Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn 
705                 710                 715                 720 


Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro 
                725                 730                 735     


Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745     


<210>  28
<211>  814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cmyc-scfv-gblock

<400>  28
tctccctgtc tctgggtaaa ggcggaggtg gatccggagg gggcggatct gacatccaga       60

tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc      120

gggcaagtca gagcattagc agctatttaa attggtatca acagaaacca gggaaagccc      180

ctaagctcct gatctatgct gtttccattt tgcaaagtgg ggtcccatca aggttcagtg      240

gcagtggatc tgggacagat ttcactctca ccatcaactc tctgcaacct gaagattttg      300

caacttactc ctgtcaacag acttacagta cccctccgat caccttcggc caagggacac      360

gactggagat taaaggaggg ggcggctcag gaggaggggg tagtggggga ggcggctccg      420

aggtgcagct ggtggagtct gggggaggct tggtacagcc tggagggtcc ctgagactct      480

cctgtgtcac ctctggattt cgttttagta gttatgaaat gaactgggtc cgccaggctc      540

cagggaaggg gctggaatgg atttcataca ttaacagaag tggttatacc atatactacg      600

cagcctctct gaagggccga ttcaccatct ccagagacaa cgccaagaac tcactgtatc      660

ttcaaatgaa cagcctgaga gacgaggaca cggctatcta ttactgtgcg agagggagta      720

tcgcccctcg gggggagatt cgacacatct ttgactactg gggccaggga accctggtca      780

ccgtctcctc atgatgagcg gccgctaatc agcc                                  814


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc HCVR AA

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Phe Arg Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Asn Arg Ser Gly Tyr Thr Ile Tyr Tyr Ala Ala Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ile Ala Pro Arg Gly Glu Ile Arg His Ile Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120 


<210>  30
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc LCVR AA

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   myc HCDR1

<400>  31

Gly Phe Arg Phe Ser Ser Tyr Glu 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc HCDR2 AA

<400>  32

Ile Asn Arg Ser Gly Tyr Thr Ile 
1               5               


<210>  33
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc HCDR3

<400>  33

Ala Arg 
1       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc LCDR1 AA

<400>  34

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc LCDR2

<400>  35

Ala Ala Ser 
1           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myc LCDR3 AA

<400>  36

Gln Gln Ser Tyr Ser Thr Pro 
1               5           


<210>  37
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-myc scFv

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Val Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Thr Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Val Thr Ser Gly Phe Arg Phe Ser Ser Tyr Glu Met Asn Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ser Tyr Ile Asn Arg 
                165                 170                 175     


Ser Gly Tyr Thr Ile Tyr Tyr Ala Ala Ser Leu Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Asp Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly Ser Ile 
    210                 215                 220                 


Ala Pro Arg Gly Glu Ile Arg His Ile Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  38
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-myc scFv NA

<400>  38
ggcggaggtg gatccggagg gggcggatct gacatccaga tgacccagtc tccatcctcc       60

ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc gggcaagtca gagcattagc      120

agctatttaa attggtatca acagaaacca gggaaagccc ctaagctcct gatctatgct      180

gtttccattt tgcaaagtgg ggtcccatca aggttcagtg gcagtggatc tgggacagat      240

ttcactctca ccatcaactc tctgcaacct gaagattttg caacttactc ctgtcaacag      300

acttacagta cccctccgat caccttcggc caagggacac gactggagat taaaggaggg      360

ggcggctcag gaggaggggg tagtggggga ggcggctccg aggtgcagct ggtggagtct      420

gggggaggct tggtacagcc tggagggtcc ctgagactct cctgtgtcac ctctggattt      480

cgttttagta gttatgaaat gaactgggtc cgccaggctc cagggaaggg gctggaatgg      540

atttcataca ttaacagaag tggttatacc atatactacg cagcctctct gaagggccga      600

ttcaccatct ccagagacaa cgccaagaac tcactgtatc ttcaaatgaa cagcctgaga      660

gacgaggaca cggctatcta ttactgtgcg agagggagta tcgcccctcg gggggagatt      720

cgacacatct ttgactactg gggccaggga accctggtca ccgtctcctc atga            774


<210>  39
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  myc HCVR NA

<400>  39
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgtca cctctggatt tcgttttagt agttatgaaa tgaactgggt ccgccaggct      120

ccagggaagg ggctggaatg gatttcatac attaacagaa gtggttatac catatactac      180

gcagcctctc tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

cttcaaatga acagcctgag agacgaggac acggctatct attactgtgc gagagggagt      300

atcgcccctc ggggggagat tcgacacatc tttgactact ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  40
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  myc LCVR NA

<400>  40
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


