                         SEQUENCE LISTING

<110>  DEVELOPMENT CENTER FOR BIOTECHNOLOGY
 
<120>  ANTI-VEGFR ANTIBODY AND USES THEREOF

<130>  none

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser His Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu 
        755                 760                 


<210>  2
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Glu Ile Thr Leu Gln Pro Asp Met Gln Pro Thr Glu Gln Glu Ser 
1               5                   10                  15      


Val Ser Leu Trp Cys Thr Ala Asp Arg Ser Thr Phe Glu Asn Leu Thr 
            20                  25                  30          


Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro Ile His Val Gly Glu Leu 
        35                  40                  45              


Pro Thr Pro Val Cys Lys Asn Leu Asp Thr Leu Trp Lys Leu Asn Ala 
    50                  55                  60                  


Thr Met Phe Ser Asn Ser Thr Asn Asp Ile Leu Ile Met Glu Leu Lys 
65                  70                  75                  80  


Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr Val Cys Leu Ala Gln Asp 
                85                  90                  95      


Arg Lys Thr Lys Lys Arg His Cys Val Val Arg Gln Leu Thr 
            100                 105                 110 


<210>  3
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Thr Ile Thr Gly Asn Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu 
1               5                   10                  15      


Ser Ile Glu Val Ser Cys Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile 
            20                  25                  30          


Met Trp Phe Lys Asp Asn Glu Thr Leu Val Glu Asp Ser Gly Ile Val 
        35                  40                  45              


Leu Lys Asp Gly Asn Arg Asn Leu Thr Ile Arg Arg Val Arg Lys Glu 
    50                  55                  60                  


Asp Glu Gly Leu Tyr Thr Cys Gln Ala Cys Ser Val Leu Gly Cys Ala 
65                  70                  75                  80  


Lys Val Glu Ala Phe Phe Ile 
                85          


<210>  4
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  4

Gly Tyr Ala Phe Thr Thr Tyr Trp Met His 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ile Asp Phe Ser Asp Ser Glu Thr Lys Leu Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Val Arg Gly Asn Phe Asp Val 
1               5               


<210>  7
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  7

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  8
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  8

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  9

Gln His Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  10

Gly Tyr Ser Phe Thr Asp Tyr Ser Met Tyr 
1               5                   10  


<210>  11
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  11

Tyr Ile Asp Pro Tyr Asn Asp Asp Thr Ser Tyr Lys Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Gly Tyr Ala Asp Ala Met Asp Tyr 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  13

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  14

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  15

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  16
<211>  351
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(351)

<400>  16
gag gtg cag ctg cag cag tct ggg cct cag ctg gtt agg cct ggg gct         48
Glu Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala           
1               5                   10                  15                

tca gcg aag ata tcc tgc aag gct tct ggt tac gca ttc acc acc tac         96
Ser Ala Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Thr Tyr           
            20                  25                  30                    

tgg atg cac tgg gtg aaa cag agg cct gga caa ggt ctt gag tgg att        144
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggc atg att gat ttt tcc gat agt gaa act aag tta aat cag agg ttc        192
Gly Met Ile Asp Phe Ser Asp Ser Glu Thr Lys Leu Asn Gln Arg Phe           
    50                  55                  60                            

aag ggc aag gcc aca ttg act gtt gac aaa tcc tcc agc aca gcc tac        240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg caa ctc agc agc ccg aca tct gag gac tct gcg gtc tat tac tgt        288
Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga gat gtc aga ggg aac ttc gat gtc tgg ggc gca ggg acc acg        336
Ala Arg Asp Val Arg Gly Asn Phe Asp Val Trp Gly Ala Gly Thr Thr           
            100                 105                 110                   

gtc acc gtc tcc tca                                                    351
Val Thr Val Ser Ser                                                       
        115                                                               


<210>  17
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  17

Glu Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Ala Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Phe Ser Asp Ser Glu Thr Lys Leu Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Arg Gly Asn Phe Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  336
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(336)

<400>  18
gat att gtg ttg aca cag tct cct gct tcc tta gct gta tct ctg ggg         48
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

cag agg gcc acc atc tca tgc agg gcc agc aaa agt gtc agt aca tct         96
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser           
            20                  25                  30                    

ggc tat agt tat atg cac tgg tac caa cag aaa cca gga cag cca ccc        144
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro           
        35                  40                  45                        

aaa ctc ctc atc tat ctt gca tcc aac cta gaa tct ggg gtc cct gcc        192
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala           
    50                  55                  60                            

agg ttc agt ggc agt ggg tct ggg aca gac ttc acc ctc aac atc cat        240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His           
65                  70                  75                  80            

cct gtg gag gag gag gat gct gca acc tat tac tgt cag cac agt agg        288
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg           
                85                  90                  95                

gag ctt ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa cgt        336
Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg           
            100                 105                 110                   


<210>  19
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  19

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  20
<211>  351
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(351)

<400>  20
cag gtc cag ctg cag cag tct gga cct gaa ctg gtg aag cct ggg gct         48
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gta tcc tgc aag gct tct ggt tac tca ttc act gac tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr           
            20                  25                  30                    

agc atg tac tgg gtg aag cag agc cat gga aag agc ctt gag tgg att        144
Ser Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile           
        35                  40                  45                        

gga tat att gat cct tac aat gat gat act agc tac aag cag aag ttc        192
Gly Tyr Ile Asp Pro Tyr Asn Asp Asp Thr Ser Tyr Lys Gln Lys Phe           
    50                  55                  60                            

aag ggc aag gcc aca ttg act gtt gac aag tcc tcc agc aca gcc ttc        240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe           
65                  70                  75                  80            

atg cat ctc aac agc ctg aca tct gag gac tct gca gtc tat tac tgt        288
Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aag ggt tac gcg gat gct atg gac tac tgg ggt caa gga acc tca        336
Ala Lys Gly Tyr Ala Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser           
            100                 105                 110                   

gtc acc gtc tcc tca                                                    351
Val Thr Val Ser Ser                                                       
        115                                                               


<210>  21
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Asp Asp Thr Ser Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Ala Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  22
<211>  324
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(324)

<400>  22
gat att cag atg att cag tct cca tcc agt ctg tct gca tcc ctt gga         48
Asp Ile Gln Met Ile Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly           
1               5                   10                  15                

gac aca att acc atc act tgc cat gcc agt cag aac att aat gtt tgg         96
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp           
            20                  25                  30                    

tta agc tgg tac cag cag aaa cca gga aat att cct aaa cta ttg atc        144
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat aag gct tcc aac ttg cac aca ggc gtc cca tca agg ttt agt ggc        192
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct gga aca ggt ttc aca tta acc atc agc agc ctg cag cct        240
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gac att gcc acc tac tac tgt caa cag ggt caa agt tat ccg ctc        288
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu           
                85                  90                  95                

acg ttc ggt gct ggg acc aag ctg gag ctg aaa cgg                        324
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg                           
            100                 105                                       


<210>  23
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  23

Asp Ile Gln Met Ile Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  24
<211>  351
<212>  DNA
<213>  artificial

<220>
<223>  humanized antibody


<220>
<221>  CDS
<222>  (1)..(351)

<400>  24
caa gtg cag ctg gtg cag tct ggc gcc gaa gtg aag aaa cca ggc gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

agc gtg aag gtg tcc tgc aag gcc agc ggc tac gcc ttc acc acc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Thr Tyr           
            20                  25                  30                    

tgg atg cat tgg gtg cgc cag gcc cct gga cag ggc ctg gaa tgg atc        144
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggc atg atc gac ttc agc gac agc gag aca aag ctg aac cag cgg ttc        192
Gly Met Ile Asp Phe Ser Asp Ser Glu Thr Lys Leu Asn Gln Arg Phe           
    50                  55                  60                            

aag ggc aag gcc acc ctg acc gtg gac aag agc acc agc acc gcc tac        240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gaa ctg agc agc ctg cgg agc gag gac acc gcc gtg tac tac tgc        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gct aga gat gtg cgg ggc aac ttc gac gtg tgg ggc cag gga aca ctc        336
Ala Arg Asp Val Arg Gly Asn Phe Asp Val Trp Gly Gln Gly Thr Leu           
            100                 105                 110                   

gtg acc gtg tct agc                                                    351
Val Thr Val Ser Ser                                                       
        115                                                               


<210>  25
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Phe Ser Asp Ser Glu Thr Lys Leu Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Arg Gly Asn Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  26
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody


<220>
<221>  CDS
<222>  (1)..(336)

<400>  26
gac atc cag atg acc cag agc ccc agc agc ctg tct gcc agc gtg ggc         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtg acc atc acc tgt cgg gcc agc aag agc gtg tcc acc agc         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser           
            20                  25                  30                    

ggc tac agc tac atg cac tgg tat cag cag aag ccc ggc aag gcc ccc        144
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro           
        35                  40                  45                        

aag ctg ctg atc tac ctg gcc agc aac ctg gaa agc ggc gtg ccc agc        192
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser           
    50                  55                  60                            

aga ttt tcc ggc agc ggc tct ggc acc gac ttc acc ctg acc atc agc        240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser           
65                  70                  75                  80            

tcc ctg cag ccc gag gac ttc gcc acc tac tac tgc cag cac agc aga        288
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg           
                85                  90                  95                

gag ctg ccc tgg acc ttt ggc cag ggc acc aag gtg gaa atc aag cgg        336
Glu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg           
            100                 105                 110                   


<210>  27
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


