                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  CHEMICALLY-MODIFIED ANTISENSE MICRORNA-214 AND USE OF SAME FOR 
       TREATMENT OF ULCERATIVE COLITIS AND PROCTITIS

<130>  UCLA.256WOU1

<150>  US 62/528,307
<151>  2017-07-03

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  1
acagcaggca cagacaggca gu                                                22


<210>  2
<211>  17
<212>  RNA
<213>  Homo sapiens

<400>  2
gacaggcagu cacauga                                                      17


<210>  3
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (1)..(15)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  m5c

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  Locked nucleic acid

<400>  3
tgtctgtgcc tgctg                                                        15


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  m5c

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  m5c

<220>
<221>  modified_base
<222>  (18)..(19)
<223>  Locked nucleic acid

<400>  4
tgcctgtctg tgcctgctg                                                    19


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  m5c

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  m5c

<400>  5
tgcctgtctg tgcctgctg                                                    19


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (2)..(3)
<223>  m5c

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  m5c

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  m5c

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  Locked nucleic acid

<400>  6
gcctgtctgt gcctgctg                                                     18


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (2)..(3)
<223>  m5c

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  m5c

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  m5c

<400>  7
gcctgtctgt gcctgctg                                                     18


<210>  8
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(17)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  m5c

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  m5c

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  Locked nucleic acid

<400>  8
tcatgtgact gcctgtc                                                      17


<210>  9
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(17)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  m5c

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  m5c

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  m5c

<400>  9
tcatgtgact gcctgtc                                                      17


<210>  10
<211>  22
<212>  RNA
<213>  Mus musculus

<400>  10
acagcaggca cagacaggca gu                                                22


<210>  11
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide

<400>  11
tgtctgtgcc tgctg                                                        15


<210>  12
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (6)..(7)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  m5c

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (14)..(15)
<223>  Locked nucleic acid

<400>  12
tgtctgtgcc tgctg                                                        15


<210>  13
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  m5c

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  m5c

<220>
<221>  modified_base
<222>  (14)..(15)
<223>  Locked nucleic acid

<400>  13
tgtctgtgcc tgctg                                                        15


<210>  14
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  m5c

<220>
<221>  modified_base
<222>  (6)..(8)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  Locked nucleic acid

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  m5c

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  m5c

<220>
<221>  modified_base
<222>  (14)..(15)
<223>  Locked nucleic acid

<400>  14
tgtctgtgcc tgctg                                                        15


<210>  15
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  Phosphorothioate linkage

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  m5c

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  m5c

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  m5c

<400>  15
tgtctgtgcc tgctg                                                        15


<210>  16
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide

<400>  16
gcctgctg                                                                 8


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide

<400>  17
tgcctgtctg tgcctgctg                                                    19


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide

<400>  18
gcctgtctgt gcctgctg                                                     18


<210>  19
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  19
ggccuggcug gacagaguug ucaugugucu gccugucuac acuugcugug cagaacaucc       60

gcucaccugu acagcaggca cagacaggca gucacaugac aacccagccu                 110


<210>  20
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic antisense oligonucleotide

<400>  20
tcatgtgact gcctgtc                                                      17


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
atggccacga ttatgtctcc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gcccatcatg gtgactaagg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
atgttcgtca tgggtgtgaa                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
ggtgctaagc agttggtggt                                                   20


