                         SEQUENCE LISTING

<110>  IONTAS LTD
 
<120>  Ion Channel Inhibitors

<130>  NRS/CP7376486

<150>  GB 1711208.7
<151>  2017-07-12

<160>  389   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytokine linker

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytokine linker

<400>  2

Gly Gly Ser Gly 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  3

Asp Pro Gly Gly 
1               


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  4

Tyr Pro Gly Asp Pro 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  5

Pro Asp Pro Gly Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker

<400>  6

Tyr Pro Gly Gly Pro 
1               5   


<210>  7
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Huwentoxin-IV

<400>  7
gagtgcctgg aaatcttcaa ggcctgcaac cccagcaacg accagtgctg caagagcagc       60

aagctcgtgt gcagcagaaa gacccggtgg tgcaagtacc agatctccag atgacccaga      120

gcccaagcag cctgagcgcc a                                                141


<210>  8
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huwentoxin-IV

<400>  8

Glu Cys Leu Glu Ile Phe Lys Ala Cys Asn Pro Ser Asn Asp Gln Cys 
1               5                   10                  15      


Cys Lys Ser Ser Lys Leu Val Cys Ser Arg Lys Thr Arg Trp Cys Lys 
            20                  25                  30          


Tyr Gln Ile Gly Lys 
        35          


<210>  9
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ProTx-II

<400>  9
tactgccaga aatggatgtg gacctgcgac agcgagcgga agtgctgcga gggcatggtg       60

tgccggctgt ggtgcaagaa aaagctgtgg tccagatgac ccagagccca agcagcctga      120

gcgcca                                                                 126


<210>  10
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProTx-II

<400>  10

Tyr Cys Gln Lys Trp Met Trp Thr Cys Asp Ser Glu Arg Lys Cys Cys 
1               5                   10                  15      


Glu Gly Met Val Cys Arg Leu Trp Cys Lys Lys Lys Leu Trp 
            20                  25                  30  


<210>  11
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssm6a

<400>  11
gccgacaaca agtgcgagaa cagcctgcgg agagagatcg cctgcggcca gtgccgggac       60

aaagtgaaaa ccgacggcta cttctacgag tgctgcacca gcgacagcac cttcaagaag      120

tgccaggacc tgctgcactc cagatgaccc agagcccaag cagcctgagc gcca            174


<210>  12
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ssm6a

<400>  12

Ala Asp Asn Lys Cys Glu Asn Ser Leu Arg Arg Glu Ile Ala Cys Gly 
1               5                   10                  15      


Gln Cys Arg Asp Lys Val Lys Thr Asp Gly Tyr Phe Tyr Glu Cys Cys 
            20                  25                  30          


Thr Ser Asp Ser Thr Phe Lys Lys Cys Gln Asp Leu Leu His 
        35                  40                  45      


<210>  13
<211>  149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kaliotoxin (KTX)

<400>  13
atctatgctg cagggagggg tgtggaaatt aacgtgaagt gtagcgggag cccacagtgc       60

cttaaaccat gcaaagatgc ggggatgcgc tttggaaagt gcatgaaccg taaatgccac      120

tgcacgccga aggccaactc cggagtctc                                        149


<210>  14
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kaliotoxin (KTX)

<400>  14

Gly Val Glu Ile Asn Val Lys Cys Ser Gly Ser Pro Gln Cys Leu Lys 
1               5                   10                  15      


Pro Cys Lys Asp Ala Gly Met Arg Phe Gly Lys Cys Met Asn Arg Lys 
            20                  25                  30          


Cys His Cys Thr Pro 
        35          


<210>  15
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mokatoxin-1 (MoKa-1)

<400>  15
atcaacgtga agtgcagcct gccccagcag tgcatcaagc cctgcaagga cgccggcatg       60

agattcggca agtgcatgaa caagaaatgc cggtgctaca gctccagatg acccagagcc      120

caagcagcct gagcgcca                                                    138


<210>  16
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mokatoxin-1 (MoKa-1)

<400>  16

Ile Asn Val Lys Cys Ser Leu Pro Gln Gln Cys Ile Lys Pro Cys Lys 
1               5                   10                  15      


Asp Ala Gly Met Arg Phe Gly Lys Cys Met Asn Lys Lys Cys Arg Cys 
            20                  25                  30          


Tyr Ser 
        


<210>  17
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Shk

<400>  17
agaagctgca tcgacaccat ccccaagagc agatgcaccg ccttccagtg caagcacagc       60

atgaagtacc ggctgagctt ctgtagaaag acctgcggca cctgttccag atgacccaga      120

gcccaagcag cctgagcgcc a                                                141


<210>  18
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shk

<400>  18

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Gln 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  19
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PcTX1

<400>  19
gaggactgca tccccaagtg gaagggctgc gtgaacagac acggcgactg ttgcgagggc       60

ctggaatgct ggaagcggag gcggagcttc gaagtgtgcg tgcccaagac ccctaagacc      120

tccagatgac ccagagccca agcagcctga gcgcca                                156


<210>  20
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PcTX1

<400>  20

Glu Asp Cys Ile Pro Lys Trp Lys Gly Cys Val Asn Arg His Gly Asp 
1               5                   10                  15      


Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg Arg Ser Phe Glu Val 
            20                  25                  30          


Cys Val Pro Lys Thr Pro Lys Thr 
        35                  40  


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EETI-II

<400>  21

Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu 
1               5                   10                  15      


Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly Ser Pro 
            20                  25                  30  


<210>  22
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conotoxin-omega


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Cys Lys Gly Lys Gly Ala Lys Cys Ser Arg Leu Met Tyr Asp Cys Cys 
1               5                   10                  15      


Thr Gly Ser Cys Arg Ser Gly Lys Cys Xaa 
            20                  25      


<210>  23
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCoTI-II

<400>  23

Ser Gly Ser Asp Gly Gly Val Cys Pro Lys Ile Leu Lys Lys Cys Arg 
1               5                   10                  15      


Arg Asp Ser Asp Cys Pro Gly Ala Cys Ile Cys Arg Gly Asn Gly Tyr 
            20                  25                  30          


Cys Gly 
        


<210>  24
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mambalgin-1 (Mba-1)

<400>  24

Leu Lys Cys Tyr Gln His Gly Lys Val Val Thr Cys His Arg Asp Met 
1               5                   10                  15      


Lys Phe Cys Tyr His Asn Thr Gly Met Pro Phe Arg Asn Leu Lys Leu 
            20                  25                  30          


Ile Leu Gln Gly Cys Ser Ser Ser Cys Ser Glu Thr Glu Asn Asn Lys 
        35                  40                  45              


Cys Cys Ser Thr Asp Arg Cys Asn Lys 
    50                  55          


<210>  25
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mambalgin-2 (Mba-2)

<400>  25

Leu Lys Cys Phe Gln His Gly Lys Val Val Thr Cys His Arg Asp Met 
1               5                   10                  15      


Lys Phe Cys Tyr His Asn Thr Gly Met Pro Phe Arg Asn Leu Lys Leu 
            20                  25                  30          


Ile Leu Gln Gly Cys Ser Ser Ser Cys Ser Glu Thr Glu Asn Asn Lys 
        35                  40                  45              


Cys Cys Ser Thr Asp Arg Cys Asn Lys 
    50                  55          


<210>  26
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ad-LOX1-A

<400>  26

Ala Thr Gly Val Arg Ala Val Pro Gly Asn Glu Asn Ser Leu Glu Ile 
1               5                   10                  15      


Glu Glu Leu Ala Arg Phe Ala Val Asp Glu His Asn Lys Lys Glu Asn 
            20                  25                  30          


Ala Leu Leu Glu Phe Val Arg Val Val Lys Ala Lys Glu Gln Thr Ala 
        35                  40                  45              


His Leu Asp Pro Leu Met Asp Thr Met Tyr Tyr Leu Thr Leu Glu Ala 
    50                  55                  60                  


Lys Asp Gly Gly Lys Lys Lys Leu Tyr Glu Ala Lys Val Trp Val Lys 
65                  70                  75                  80  


Phe Trp Met Ile Ser Asp Leu Ile Phe Asn Phe Lys Glu Leu Gln Glu 
                85                  90                  95      


Phe Lys Pro Val Gly Asp Ala 
            100             


<210>  27
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ad-LOX1-B

<400>  27

Ala Thr Gly Val Arg Ala Val Pro Gly Asn Glu Asn Ser Leu Glu Ile 
1               5                   10                  15      


Glu Glu Leu Ala Arg Phe Ala Val Asp Glu His Asn Lys Lys Glu Asn 
            20                  25                  30          


Ala Leu Leu Glu Phe Val Arg Val Val Lys Ala Lys Glu Gln Glu Gln 
        35                  40                  45              


Pro Ile Gly Glu His Pro Val Asn Asp Thr Met Tyr Tyr Leu Thr Leu 
    50                  55                  60                  


Glu Ala Lys Asp Gly Gly Lys Lys Lys Leu Tyr Glu Ala Lys Val Trp 
65                  70                  75                  80  


Val Lys Arg Trp Leu Arg Phe Thr Glu Ile Tyr Asn Phe Lys Glu Leu 
                85                  90                  95      


Gln Glu Phe Lys Pro Val Gly Asp Ala 
            100                 105 


<210>  28
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fibronectin domain

<400>  28

Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser 
1               5                   10                  15      


Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly 
            20                  25                  30          


Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser 
        35                  40                  45              


Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr 
    50                  55                  60                  


Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser 
65                  70                  75                  80  


Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile 
                85                  90      


<210>  29
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T7 Gp2 protein

<400>  29

Met Ser Asn Val Asn Thr Gly Ser Leu Ser Val Asp Asn Lys Lys Phe 
1               5                   10                  15      


Trp Ala Thr Val Glu Ser Ser Glu His Ser Phe Glu Val Pro Ile Tyr 
            20                  25                  30          


Ala Glu Thr Leu Asp Glu Ala Leu Glu Leu Ala Glu Trp Gln Tyr Val 
        35                  40                  45              


Pro Ala Gly Phe Glu Val Thr Arg Val Arg Pro Cys Val Ala Pro Lys 
    50                  55                  60                  


<210>  30
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1 A12 (VH)

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Asp Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Phe Gly Pro Gly Tyr Gly Thr Gly Trp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  31
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A07 ShK (VL)

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Val Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg 
    50                  55                  60                  


Cys Thr Ala Phe Gln Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe 
65                  70                  75                  80  


Cys Arg Lys Thr Cys Gly Thr Cys Ser Arg Ser Gly Val Pro Ser Arg 
                85                  90                  95      


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            100                 105                 110         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Ser 
        115                 120                 125             


Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
    130                 135                 140             


<210>  32
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12 ShK (VL)

<400>  32

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser 
    50                  55                  60                  


Arg Cys Thr Ala Phe Gln Cys Lys His Ser Met Lys Tyr Arg Leu Ser 
65                  70                  75                  80  


Phe Cys Arg Lys Thr Cys Gly Thr Cys Ala Asn Ser Gly Val Ser Asp 
                85                  90                  95      


Arg Phe Ser Ala Ala Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Asn 
            100                 105                 110         


Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
        115                 120                 125             


Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val 
    130                 135                 140                 


Leu Gly 
145     


<210>  33
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A-07 Kaliotoxin (VL)

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Val Gly Val Glu Ile Asn Val Lys Cys Ser Gly Ser 
    50                  55                  60                  


Pro Gln Cys Leu Lys Pro Cys Lys Asp Ala Gly Met Arg Phe Gly Lys 
65                  70                  75                  80  


Cys Met Asn Arg Lys Cys His Cys Thr Pro Lys Ser Arg Ser Gly Val 
                85                  90                  95      


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Gly Ala Ser Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
    130                 135                 140                 


Lys Arg 
145     


<210>  34
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12 PcTx1 (VL)

<400>  34

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Glu Asp Cys Ile Pro Lys Trp Lys Gly Cys 
    50                  55                  60                  


Val Asn Arg His Gly Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg 
65                  70                  75                  80  


Arg Arg Ser Phe Glu Val Cys Val Pro Lys Thr Pro Lys Thr Ala Asn 
                85                  90                  95      


Ser Gly Val Ser Asp Arg Phe Ser Ala Ala Lys Ser Gly Thr Ser Ala 
            100                 105                 110         


Ser Leu Ala Ile Asn Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr 
        115                 120                 125             


Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly 
    130                 135                 140                 


Thr Lys Leu Thr Val Leu Gly 
145                 150     


<210>  35
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A07 PcTx1 (VL)

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Val Glu Asp Cys Ile Pro Lys Trp Lys Gly Cys Val 
    50                  55                  60                  


Asn Arg His Gly Asp Cys Cys Glu Gly Leu Glu Cys Trp Lys Arg Arg 
65                  70                  75                  80  


Arg Ser Phe Glu Val Cys Val Pro Lys Thr Pro Lys Thr Ser Arg Ser 
                85                  90                  95      


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            100                 105                 110         


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
        115                 120                 125             


Gln Gln Gly Ala Ser Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val 
    130                 135                 140                 


Glu Ile Lys Arg 
145             


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag protein

<400>  36

Met Arg Gly Ser His His His His His His 
1               5                   10  


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag protein

<400>  37

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag protein

<400>  38

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag protein

<400>  39

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag protein

<400>  40

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag protein

<400>  41

Met Lys Ala Glu Phe Arg Arg Gln Glu Ser Asp Arg 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag protein

<400>  42

Met Arg Asp Ala Leu Asp Arg Leu Asp Arg Leu Ala 
1               5                   10          


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain germline gene segment

<400>  43
ggtacctcgc gaatgcatct ag                                                22


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain germline gene segment

<400>  44
catgcaggcc tctgcagtcg                                                   20


<210>  45
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pml1-5EETa


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  S=C or G

<400>  45
gtgtvnsvns vnstgcccgc gtatcctgat gcgttgc                                37


<210>  46
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pml1-5EETb


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  S=C or G

<400>  46
gtgtggavns vnsvnstgcc cgcgtatcct gatgcgttgc                             40


<210>  47
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  restriction enzyme sequence

<400>  47
cacgtg                                                                   6


<210>  48
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-5EETMfe


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  B=T, G or C

<400>  48
gtcagtccaa ttgnbsnbcc cgcagaagcc gttcggaccg ca                          42


<210>  49
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PST1-5EETa


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  N= A, C, G or T

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  N= A, C, G or T

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  S=C or G

<400>  49
atctatgctg cagnsvnstg cccgcgtatc ctgatgcgtt gc                          42


<210>  50
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-5EETBse


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  B=T, G or C

<400>  50
gtcagagact ccggasnbsn bcccgcagaa gccgttcgga ccgca                       45


<210>  51
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mfelam 1

<400>  51
gtgtggaggt ggcaattggt accagcagct cccagg                                 36


<210>  52
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mfelam 2

<400>  52
gtgtggaggt ggcaattggt accaacagca cccagg                                 36


<210>  53
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mfelam 3

<400>  53
gtgtggaggt ggcaattggt accagcagaa gcca                                   34


<210>  54
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mfekap 1

<400>  54
gtgtggaggt ggcaattggt atcagcagaa accagg                                 36


<210>  55
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mfekap 2

<400>  55
gtgtggaggt ggcaattggt acctgcagaa gccagg                                 36


<210>  56
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mfekap 3

<400>  56
gtgtggaggt ggcaattggt accagcagaa acctgg                                 36


<210>  57
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JLFORQP2

<400>  57
tgagatgagt ttttgttctg cggccgcggg ctgacctag                              39


<210>  58
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JKFOR_Thr2

<400>  58
tgagatgagt ttttgttctg cggccgcggt acgtttgat                              39


<210>  59

<400>  59
000

<210>  60
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bsplam1a

<400>  60
atctatgctg caggaggtgg ctccggagtc tctgaccgat tctctgg                     47


<210>  61
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bsplam1e

<400>  61
atctatgctg caggaggtgg ctccggagtc cctgaccgat tctctgg                     47


<210>  62
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bsplam2

<400>  62
atctatgctg caggaggtgg ctccggatcc aagtctggca acacggg                     47


<210>  63
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bsplam3

<400>  63
atctatgctg caggaggtgg ctccggaatc cctgagcgat tctctgg                     47


<210>  64
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BspKap1a

<400>  64
atctatgctg caggaggtgg ctccggagtc ccatcaaggt tcagtgg                     47


<210>  65
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BspKap1b

<400>  65
atctatgctg caggaggtgg ctccggagtc ccatcaaggt tcagcgg                     47


<210>  66
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BspKap2

<400>  66
atctatgctg caggaggtgg ctccggagtc ccagacaggt tcagtgg                     47


<210>  67
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BspKap3

<400>  67
atctatgctg caggaggtgg ctccggaatc ccagccaggt tcagtgg                     47


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EETI-II loop1

<400>  68

Gly Cys Pro Arg Ile Leu Met Arg Cys 
1               5                   


<210>  69
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL chain

<400>  69
ctctggcggt ggcgctagc                                                    19


<210>  70
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL chain

<400>  70
ggccccattc agatcctctt ctgagatgag                                        30


<210>  71
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_Heavy chain

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Asp Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asp Phe Gly Pro Gly Tyr Gly Thr Gly Trp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  72
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_Light chain

<400>  72

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ala Asn Ser Gly Val Ser Asp Arg Phe Ser Ala Ala Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Asn Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Ala Ala Ala Pro 
    130                 135                 140                 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
                165                 170                 175     


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
            180                 185                 190         


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
        195                 200                 205             


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys 
    210                 215                 220                 


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
225                 230                 235                 240 


Glu Cys Ser 
            


<210>  73
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A05 Heavy chain

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Asp Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asp Phe Gly Pro Gly Tyr Gly Thr Gly Trp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  74
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A05 Light chain

<400>  74

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Asp Lys Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Asn Leu Asn Gly Val Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Ala Ala Ala Pro 
    130                 135                 140                 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
                165                 170                 175     


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
            180                 185                 190         


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
        195                 200                 205             


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys 
    210                 215                 220                 


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
225                 230                 235                 240 


Glu Cys Ser 
            


<210>  75
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M13 leaderseq

<400>  75
aaattattat tcgcaattcc tttggttgtt cct                                    33


<210>  76
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLINK3

<400>  76
ctgaaccgcc tccaccactc ga                                                22


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3 primer

<400>  77
caggaaacag ctatgacc                                                     18


<210>  78
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D1A12-Notl Rev

<400>  78
ttctgcggcc gcggtacgtt tgatatccat t                                      31


<210>  79
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PmI5-3EETa


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  N=A, C, G, or T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  N=A, C, G, or T

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  N=A, C, G, or T

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  S=C or G

<400>  79
gtgtvnsvns vnstgcggtc cgaacggctt ctgc                                   34


<210>  80
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PmI5-3EETb


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  S=C or G

<400>  80
gtgtggavns vnsvnstgcg gtccgaacgg cttc                                   34


<210>  81
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5-3EETMfe


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  B=T, G or C

<400>  81
gtcagtccaa ttgnbsnbgc agccggccag gcagtctga                              39


<210>  82
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PST5-3EETa


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  N=A, C, T or G

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  N=A, C, T or G

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  S=C or G

<400>  82
atctatgctg cagnsvnstg cggtccgaac ggcttctgc                              39


<210>  83
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5-3EETBse


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  B=T, G or C

<400>  83
gtcagagact ccggasnbsn bcccgcagcc ggccaggcag tctga                       45


<210>  84
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_F_10

<400>  84

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Glu Arg Pro Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Ala Asn Asn Trp Tyr Gln Gln Leu Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Gln Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gln Pro 
    130                 


<210>  85
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_B_01

<400>  85

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Gly Gly Arg Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Thr Pro Asn Trp Tyr Gln Gln Leu Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Leu Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Gly Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Gln Val Phe Gly Gly Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro 
    130                 


<210>  86
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_F_02

<400>  86

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Ser Arg Pro Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Ser His Asn Trp Tyr Gln Gln Leu Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn His Arg Val Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135     


<210>  87
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_F_05

<400>  87

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Gly Gly Arg Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Thr Gly Asn Trp Tyr Gln Gln Leu Pro Gly Arg 
    50                  55                  60                  


Ser Pro Thr Asn Val Val Tyr Glu Asp Asn Gln Arg Pro Pro Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Gln Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro 
    130                 


<210>  88
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_C_12

<400>  88

Gln Ser Val Leu Thr Gln Leu Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Arg Ala Met Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Thr Gly Asn Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Ile Ile Phe Asp Val Ser Lys Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      


Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
            100                 105                 110         


Tyr Thr Ser Ser Asn Thr Trp Val Phe Gly Gly Gly Thr Gln Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro 
    130             


<210>  89
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_G_05

<400>  89

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Asp Arg Lys Cys Pro Arg Ile Leu Met Arg 
            20                  25                  30          


Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn 
        35                  40                  45              


Gly Phe Cys Gly Thr Thr Asn Trp Tyr Gln Gln Leu Pro Gly Ser Ser 
    50                  55                  60                  


Pro Thr Thr Val Ile Tyr Glu Asn Phe Gln Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu 
                85                  90                  95      


Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Ser Tyr Asp Ser Tyr Asn Gln Val Phe Gly Ser Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro 
    130             


<210>  90
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_C_06

<400>  90

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Arg Arg Gly Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Gly Asp Asn Trp Tyr Gln Gln His Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Pro Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser His Asp Gly Ser Asn Pro Trp Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Leu Gly Gln Pro 
    130                 135 


<210>  91
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_A_03

<400>  91

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Gly Arg Cys Pro Arg Ile Leu Met Arg 
            20                  25                  30          


Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn 
        35                  40                  45              


Gly Phe Cys Gly Ser Ala Asn Trp Tyr Gln Gln Leu Pro Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu 
                85                  90                  95      


Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Ser Tyr Asp Ser Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro 
    130                 


<210>  92
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_D_06

<400>  92

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Arg Gly Gly Cys Pro Arg Ile Leu Met Arg 
            20                  25                  30          


Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn 
        35                  40                  45              


Gly Phe Cys Gly Ser Pro Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Pro Ala Ser Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg 
            100                 105                 110         


Asp Asn Asp Asn Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro 
    130             


<210>  93
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_E_08

<400>  93

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Gly Thr Gly Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Ser Ala Asn Trp Tyr Gln Gln Leu Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Asn Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Asn Asp Gly Thr Asn Gly Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gln Pro 
    130                 


<210>  94
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_A_12

<400>  94

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Pro Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Ala Arg Pro Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Ala Ser Asn Trp Tyr Gln Gln Leu Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ile Asn Arg Gly Val Phe Gly Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro 
    130                 


<210>  95
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_H_03

<400>  95

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Arg Thr Gly Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Ser 
    50                  55                  60                  


Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Pro Ile Asp Ser Ser Ser Asn Ser Ala Pro 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Arg Asn Asn Val Ile Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro 
    130                 


<210>  96
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_E_10

<400>  96

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Thr Arg Gly Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Ser Asn Asn Trp Tyr Gln Gln Leu Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Tyr Gly Ser Ile Asp Ser Ser Ser Asp Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Glu Thr Glu Asp Glu Ala Asp Tyr Phe Cys 
            100                 105                 110         


His Ser Tyr Asp Ser Asp Lys Trp Val Phe Gly Gly Gly Thr Gln Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro 
    130                 


<210>  97
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_E_03

<400>  97

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Gly Met Pro Cys Pro Arg Ile Leu Met 
            20                  25                  30          


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro 
        35                  40                  45              


Asn Gly Phe Cys Gly Ala Thr Asn Trp Tyr Gln Gln Leu Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Pro Lys Val Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135     


<210>  98
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_D_02

<400>  98

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Lys Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Arg Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  99
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_D_09

<400>  99

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Asp Lys Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Asn Leu Asn Gly Val Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  100
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_H_09

<400>  100

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Val Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Gly Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Gly 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  101
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_F_02

<400>  101

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ala Arg Ser Gly Ile Pro Glu Arg Phe Ser Ala Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  102
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_C_07

<400>  102

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Arg Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Phe Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  103
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_B_07

<400>  103

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly His Thr Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  104
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_G_05

<400>  104

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Gly Arg Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  105
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_H_04

<400>  105

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ala Asn Ser Gly Val Ser Asp Arg Phe Ser Ala Ala Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Asn Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  106
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_A_01

<400>  106

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Glu Pro Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ala Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


His Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Ala Trp Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  107
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_H_07

<400>  107

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Arg Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Arg Ala Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  108
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_B_06

<400>  108

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Asp Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Asp Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  109
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_F_09

<400>  109

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Val Ile Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Gly Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  110
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_F_11

<400>  110

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Glu Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Gly Ser Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Asn Leu Asn Gly Pro Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  111
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_C_02

<400>  111

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Val Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ser Ala Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu Arg Gly Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  112
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_D_08

<400>  112

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Pro Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  113
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_E_10

<400>  113

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  114
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_F_05

<400>  114

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ser Asn Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  115
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_G_04

<400>  115

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Met Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Gly His Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  116
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_A_08

<400>  116

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Arg Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Gly Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  117
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_E_06

<400>  117

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Asp Lys Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Leu Thr Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu Asn Gly Val Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  118
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_B_11

<400>  118

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Lys Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Gly Ala Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Ile Asp Ser 
                85                  90                  95      


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Pro Glu Asp 
            100                 105                 110         


Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Arg Trp Val 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
    130                 135                 140     


<210>  119
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_G_09

<400>  119

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Thr Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser 
                85                  90                  95      


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Glu Leu Lys Thr Glu Asp 
            100                 105                 110         


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Gln Gly Trp 
        115                 120                 125             


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140         


<210>  120
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_C_08

<400>  120

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser 
                85                  90                  95      


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Arg Ala Glu Asp 
            100                 105                 110         


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn His Trp Val 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140     


<210>  121
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_E_09

<400>  121

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Pro Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Pro Arg Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser 
                85                  90                  95      


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp 
            100                 105                 110         


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Asn Asn His Trp Val 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140     


<210>  122
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_F_04

<400>  122

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Glu Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Thr 
                85                  90                  95      


Phe Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp 
            100                 105                 110         


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser His His Trp Val 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140     


<210>  123
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_E_05

<400>  123

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Pro Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ala Asp Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Gly 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  124
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_D_07

<400>  124

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Arg Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Thr 
                85                  90                  95      


Phe Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp 
            100                 105                 110         


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn His Trp Val 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140     


<210>  125
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_G_03

<400>  125

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Asn Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Lys Ser Gly 
                85                  90                  95      


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  126
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_A_09

<400>  126

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ala Pro Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ala His Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg 
                85                  90                  95      


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Ile Glu Asp 
            100                 105                 110         


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn His Val Val 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
    130                 135                 140     


<210>  127
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_D_11

<400>  127

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Val Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ile Asp Arg 
                85                  90                  95      


Ser Thr Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp 
            100                 105                 110         


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Leu Asn Trp 
        115                 120                 125             


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140         


<210>  128
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_C_06

<400>  128

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Asn Ala Ala Asp Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Thr Asn Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
                85                  90                  95      


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Asn Trp Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  129
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_F_01

<400>  129

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Leu Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Gly Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Asp Ile Lys Arg Thr 
    130                 135     


<210>  130
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_F_12

<400>  130

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ala Pro Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Ser Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Asp Ile Lys Arg Thr 
    130                 135     


<210>  131
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_E_04

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ala Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Thr Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr 
    130                 135     


<210>  132
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_F_03

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ala Lys Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Ala Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr 
    130                 135     


<210>  133
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_D_03

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Val Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Thr 
    130                 135     


<210>  134
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_D_06

<400>  134

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Thr Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Asp Ile Lys Arg Thr 
    130                 135     


<210>  135
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_C_09

<400>  135

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Ala Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Phe Gly Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Thr 
    130                 135     


<210>  136
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_E_08

<400>  136

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Ser Arg Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Gly Ala Ser Pro Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr 
    130                 135     


<210>  137
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_G_11

<400>  137

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Gly His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Thr 
    130                 135     


<210>  138
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_B_03

<400>  138

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Gly Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Glu Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Gly Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                85                  90                  95      


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Lys Val Asp Asp Tyr Pro Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr 
    130                 135     


<210>  139
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2_H_02

<400>  139

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Glu Ile Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Pro Ser Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Tyr Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser Glu Asp Ala Ala Tyr 
            100                 105                 110         


Tyr Phe Cys Leu Gln His Asp Asn Phe Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr 
    130                 135     


<210>  140
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_C_12

<400>  140

Gly Arg Ala Met 
1               


<210>  141
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_F_02

<400>  141

Gly Ser Arg Pro 
1               


<210>  142
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1_F_10

<400>  142

Gly Glu Arg Pro 
1               


<210>  143
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_F03

<400>  143

His Ala Ala Asn Trp Glu Glu Pro Gly Phe Asp Pro 
1               5                   10          


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_E05

<400>  144

Arg Ser Ser Ala Gly Asp Gly Ala Tyr Phe Asp Tyr 
1               5                   10          


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_E02

<400>  145

Asp Arg Gly Leu Gly Thr Ser Thr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  146
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_D10

<400>  146

Ser Gln Ser Gly Val Gly Gly Thr Gly Phe Asp Pro 
1               5                   10          


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TR_A08

<400>  147

Gln Leu Gly Gly Thr Phe Asp Val 
1               5               


<210>  148
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_E10

<400>  148

Ala Leu Asp Gly Ala Trp Thr Asp Tyr Gly Asp Ser His Glu Ala Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_B08

<400>  149

Ser Phe Asp Tyr Gly Asp Pro Phe Asp Tyr 
1               5                   10  


<210>  150
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_C12

<400>  150

Ser Gly Ala Val Gly Ala Arg Asp Ala Phe Asp Ile 
1               5                   10          


<210>  151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_F01

<400>  151

Asp Arg Ile Gly Glu Gly Ile Pro Met Asp Val 
1               5                   10      


<210>  152
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_A10

<400>  152

Gly Gly Ile Val Gly Ala Thr Asn Asp Ala Phe Asp Ile 
1               5                   10              


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_B02

<400>  153

Ala Gly Ala Gly Glu Gly Gly Met Asp Val 
1               5                   10  


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_H03

<400>  154

Asp Asn Pro Leu Arg Gly Met Asp Val 
1               5                   


<210>  155
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_A07

<400>  155

Glu Ser Gly Gly Thr Asn Gly Trp Asp Ala Phe Asp Met 
1               5                   10              


<210>  156
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_B07

<400>  156

Gly Glu Arg Pro Asp Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_C04

<400>  157

Glu Pro Gly Gly Asp Ser Tyr Phe Asp Tyr 
1               5                   10  


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_D05

<400>  158

Met Arg Gly Tyr Asn Gly Gly Phe Asp Leu 
1               5                   10  


<210>  159
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_D01

<400>  159

Ser Gly Gly Glu Gly Val Arg Ala Tyr Gly Met Asp Val 
1               5                   10              


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_B03

<400>  160

Asp Gly Asn Val Arg Gly Met Asp Val 
1               5                   


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_D03

<400>  161

Gly Gly Ser Asp Tyr Tyr Met Asp Val 
1               5                   


<210>  162
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_H07

<400>  162

Gly Asp Ser Ser Gly Tyr Gly Ser Phe Asp Ile 
1               5                   10      


<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_G09

<400>  163

Ser Gly Gly Leu Gly Asp Ala Phe Asp Ile 
1               5                   10  


<210>  164
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_D07

<400>  164

Val Ser Thr Tyr Ser Gly Ser Gln Pro Phe Asp Tyr 
1               5                   10          


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_Tr_D09

<400>  165

Gly Ala Gly Glu Gly Tyr Phe Asp Tyr 
1               5                   


<210>  166
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Huwen_A07 Fwd

<400>  166
tatgctgcag gggtcgagtg cctggaaatc ttcaaggcct gc                          42


<210>  167
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Huwen_A07 Rev

<400>  167
tgggactccg gagcggctga tctggtactt gcaccaccgg gt                          42


<210>  168
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ProTx-II A07 Rev

<400>  168
tgggactccg gagcggctcc acagcttttt cttgcaccac ag                          42


<210>  169
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ProTx_II A07 Fwd

<400>  169
tatgctgcag gggtctactg ccagaaatgg atgtggacct g                           41


<210>  170
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssm6_A07 Fwd

<400>  170
tatgctgcag gggtcgccga caacaagtgc gagaacagcc tg                          42


<210>  171
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SSm6_A07 Rev

<400>  171
tgggactccg gagcggctgt gcagcaggtc ctggcacttc tt                          42


<210>  172
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssm6_GGS_A07 Fwd

<400>  172
tatgctgcag gggtcggcgg tagcgccgac aacaagtgcg agaacagcct g                51


<210>  173
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssm6_GGs_A07 Rev

<400>  173
gactccggag cggctaccgc cgctgtgcag caggtcctgg cacttcttga a                51


<210>  174
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kalio_A07_Fwd_B

<400>  174
atctatgctg caggggtcgg tgtggaaatt aacgtgaagt gt                          42


<210>  175
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kalio_A07 Rev

<400>  175
tgggactccg gagcggctct tcggcgtgca gtggcattta cg                          42


<210>  176
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Moka-1 A07 Fwd

<400>  176
tatgctgcag gggtcatcaa cgtgaagtgc agcctgcccc ag                          42


<210>  177
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Moka-1 A07 Rev

<400>  177
tgggactccg gagcggctgc tgtagcaccg gcatttcttg tt                          42


<210>  178
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Shk_A07 Fwd

<400>  178
tatgctgcag gggtcagaag ctgcatcgac accatcccca aga                         43


<210>  179
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Shk_A07_Rev

<400>  179
tgggactccg gagcggctac aggtgccgca ggtctttcta ca                          42


<210>  180
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PcTx-I A07 Fwd

<400>  180
tatgctgcag gggtcgagga ctgcatcccc aagtggaagg gc                          42


<210>  181
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PcTx-I A07 Rev

<400>  181
tgggactccg gagcggctgg tcttaggggt cttgggcacg ca                          42


<210>  182
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Huwen A12 Rev

<400>  182
gactccggag ttggcgatct ggtacttgca ccaccgggtc tttct                       45


<210>  183
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Huwen_A12 Fwd

<400>  183
tatgctgcag ggagggagtg cctggaaatc ttcaaggcct gc                          42


<210>  184
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ProTx-II A12 fwd

<400>  184
tatgctgcag ggaggtactg ccagaaatgg atgtggacct gc                          42


<210>  185
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ProTx-II A12 Rev

<400>  185
gactccggag ttggcccaca gctttttctt gcaccacagc cg                          42


<210>  186
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssm6a_A12 Fwd

<400>  186
tatgctgcag ggagggccga caacaagtgc gagaacagcc tg                          42


<210>  187
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssm6a_A12 Rev

<400>  187
gactccggag ttggcgtgca gcaggtcctg gcacttcttg aag                         43


<210>  188
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssm6a_GGS_A12 Fwd

<400>  188
tatgctgcag ggaggggcgg tagcgccgac aacaagtgcg agaacagcct g                51


<210>  189
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ssm6a_GGS_A12 Rev

<400>  189
actccggagt tggcaccgcc gctgtgcagc aggtcctggc acttcttgaa g                51


<210>  190
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kalio_A12 Fwd B

<400>  190
atctatgctg cagggagggg tgtggaaatt aacgtgaagt gt                          42


<210>  191
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kalio_A12 Rev

<400>  191
gagactccgg agttggcctt cggcgtgcag tggcatttac g                           41


<210>  192
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Moka1 A12 Fwd

<400>  192
tatgctgcag ggaggatcaa cgtgaagtgc agcctgcccc ag                          42


<210>  193
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Moka1_A12 Rev

<400>  193
gactccggag ttggcgctgt agcaccggca tttcttgttc at                          42


<210>  194
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Shk_A12 Fwd

<400>  194
tatgctgcag ggaggagaag ctgcatcgac accatcccca ag                          42


<210>  195
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Shk_A12 rev

<400>  195
gactccggag ttggcacagg tgccgcaggt ctttctacag aag                         43


<210>  196
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PcTx-1 A12 Fwd

<400>  196
tatgctgcag ggagggagga ctgcatcccc aagtggaagg gc                          42


<210>  197
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PcTX-1 A12 Rev

<400>  197
gactccggag ttggcggtct taggggtctt gggcacgcac ac                          42


<210>  198
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad#LOX1#A

<400>  198
gctacaggcg tgcgggctgt gcccggcaat gagaacagcc tggaaatcga ggaactggcc       60

agattcgccg tggacgagca caacaagaaa gagaacgccc tgctggaatt cgtgcgggtc      120

gtgaaggcca aagagcagtg gagcgaggcc gacaacgact ggcacaccat gtactacctg      180

accctggaag ccaaggacgg cggcaagaag aagctgtacg aggccaaagt gtgggtcaag      240

ctggacctgg aaacctggca gcacttcaac ttcaaagagc tccaggaatt caagcccgtg      300

ggcgacgct                                                              309


<210>  199
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad#LOX1#B

<400>  199
gctacaggcg tgcgggctgt gcccggcaat gagaacagcc tggaaatcga ggaactggcc       60

agattcgccg tggacgagca caacaagaaa gagaacgccc tgctggaatt cgtgcgggtc      120

gtgaaggcca aagagcagga acagcccatc ggcgagcacc ccgtgaacga caccatgtac      180

tacctgaccc tggaagccaa ggacggcggc aagaagaagc tgtacgaggc caaagtgtgg      240

gtcaagcggt ggctgcggtt caccgagatc tacaacttca aagagctcca ggaattcaag      300

cccgtgggcg acgct                                                       315


<210>  200
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad_SUMO_10 A07 Fwd

<400>  200
atctatgctg caggggtcgc tacaggcgtg cgggctgtgc ccggc                       45


<210>  201
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad_SUMO_10_A07 Rev

<400>  201
gggactccgg agcggcttgc gtcgcccacg ggcttgaatt cctgg                       45


<210>  202
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad_SUMO_10 A12 Fwd

<400>  202
atctatgctg cagggagggc tacaggcgtg cgggctgtgc ccggc                       45


<210>  203
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad_SUMO10_A12 Rev

<400>  203
gagactccgg agttggcggc gtcgcccacg ggcttgaatt cctgg                       45


<210>  204
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A07 (Gly4Ser)2

<400>  204
ggggsggggs                                                              10


<210>  205
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A07

<400>  205
ggtggcgcta gcgacataca aatgacccaa tcacctagct ctcttagtgc ctctgttggg       60

gatcgggtca ccatcacttg tagagcgagc cagagtatct catcatactt gaactggtac      120

cagcagaagc cagggaaggc ccccaagctg ttgatttacg cggctggggt ctgcccgcgc      180

atcttgatga ggtgcaaaca agactcagac tgcctggctg gatgtgtttg cggaccaaat      240

ggtttctgcg gaagccgctc aggcgtgcca tcaagattta gtggttcagg aagtggtacg      300

gacttcacgc tgacgatttc atctcttcaa cccgaagatt tcgccacgta ctactgtcaa      360

cagggtgctt ctccacctta tactttcggt cagggtacca aggttgagat taagcgcacc      420

gcggccgcaa tc                                                          432


<210>  206
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A07 Gly4Ser

<400>  206
ggtggcgcta gcgacataca aatgacccaa agtccgagct ccttgagtgc ctccgtaggt       60

gatagggtca ctattacttg cagagcgtct cagtccatct cctcctattt gaattggtac      120

caacagaaac cggggaaagc ccctaagctc ctgatctacg ccgctggggg aggcgggagt      180

ggggggggcg ggtcctgtcc gcgcatcctt atgcggtgta aacaggacag tgattgcctt      240

gctggttgtg tctgcggccc caatggtttt tgcgggggtg gggggggcag cggtgggggc      300

ggttcctccg gggtgccatc tcgctttagc ggttcaggta gtggaacgga ctttacactg      360

acaatatcat ctttgcaacc agaggatttc gccacgtact actgtcagca aggtgcctct      420

ccaccttaca cgtttggaca aggcaccaaa gtagagatta agcggaccgc ggccgcaatc      480


<210>  207
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A07 (Gly4Ser)2

<400>  207
ggtggcgcta gcgacataca aatgacccaa tcacctagct ctcttagtgc ctctgttggg       60

gatcgggtca ccatcacttg tagagcgagc cagagtatct catcatactt gaactggtac      120

cagcagaagc cagggaaggc ccccaagctg ttgatttacg cggctggcgg aggagggtcc      180

tgcccgcgca tcttgatgag gtgcaaacaa gactcagact gcctggctgg atgtgtttgc      240

ggaccaaatg gtttctgcgg aggaggcgga ggttcctcag gcgtgccatc aagatttagt      300

ggttcaggaa gtggtacgga cttcacgctg acgatttcat ctcttcaacc cgaagatttc      360

gccacgtact actgtcaaca gggtgcttct ccaccttata ctttcggtca gggtaccaag      420

gttgagatta agcgcaccgc ggccgcaatc                                       450


<210>  208
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A12

<400>  208
ggtggcgcta gccagagtgt cttgacgcag ccaccttctg tcagcgaggc cccacgccag       60

agggttacca taacatgttc cgggtccagc tctaacatag ggaataacgc ggtaaactgg      120

tatcagcaat tgcccggcaa agcaccgaaa ctcttgatct atgcagcggg gaggtgtcct      180

cgaatactga tgcgatgtaa acaggactcc gattgtcttg cgggatgtgt gtgtggtccg      240

aatgggtttt gcggcgccaa cagcggcgta agtgatcgat tctcagcggc gaaatccggc      300

acatccgcct cactggcgat caacggattg cgaagtgagg acgaagctga ctattattgc      360

gcggcctggg atgattcctt gaacgggtat gtatttggca caggaacgaa gctgactgtg      420

ctgggacaac ccgcggccgc aatc                                             444


<210>  209
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A12 Gly4Ser

<400>  209
ggtggcgcta gccagagcgt actgacgcag ccgccttctg ttagcgaggc tccccgacag       60

cgagtaacga taacgtgcag cggttcaagc agtaatatcg ggaataatgc agtaaattgg      120

tatcagcaac tgcctggaaa agcgcccaag ctgctcatat atgcggccgg gggcgggggt      180

agcggcggag ggggaagctg cccaagaatc ttgatgcggt gtaaacaaga ttcagactgt      240

ttggccggtt gcgtatgcgg tccaaatggg ttctgcggag gtggtggtgg gtccggtgga      300

ggaggtagta gcggggttag tgatcgattc tccgcggcga agtccggcac cagtgcaagt      360

ctcgctataa acgggctcag gtcagaagat gaggcagatt attactgtgc cgcatgggac      420

gacagtttga acggctatgt cttcggaacg gggactaaac ttaccgtact tggacagccc      480

gcggccgcaa tc                                                          492


<210>  210
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A12 (Gly4Ser)2

<400>  210
ggtggcgcta gccagagtgt cttgacgcag ccaccttctg tcagcgaggc cccacgccag       60

agggttacca taacatgttc cgggtccagc tctaacatag ggaataacgc ggtaaactgg      120

tatcagcaat tgcccggcaa agcaccgaaa ctcttgatct atgcagcggg agggggaggc      180

tcttgtcctc gaatactgat gcgatgtaaa caggactccg attgtcttgc gggatgtgtg      240

tgtggtccga atgggttttg cggcggtggg ggcggctcta gcggcgtaag tgatcgattc      300

tcagcggcga aatccggcac atccgcctca ctggcgatca acggattgcg aagtgaggac      360

gaagctgact attattgcgc ggcctgggat gattccttga acgggtatgt atttggcaca      420

ggaacgaagc tgactgtgct gggacaaccc gcggccgcaa tc                         462


<210>  211
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_H01

<400>  211

Cys His Arg Met Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  212
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_F05

<400>  212

Cys Lys Arg Leu Met Ser Gly Ala Gly Arg Cys 
1               5                   10      


<210>  213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_G01

<400>  213

Cys Gln Arg Gln Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_G07

<400>  214

Cys Arg Ala Ser Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  215
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_E07

<400>  215

Cys Pro Lys Arg His Thr Gly Thr Gly Arg Cys 
1               5                   10      


<210>  216
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_E04

<400>  216

Cys Gly His Leu Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  217
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_F02

<400>  217

Cys Gly Arg Ala Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  218
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_H05

<400>  218

Cys Asn Arg Ala Ser Gly Ala Gly Arg Cys 
1               5                   10  


<210>  219
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_H03

<400>  219

Cys Arg Gly Met Thr Gly Val Gly Arg Cys 
1               5                   10  


<210>  220
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_H08

<400>  220

Cys Gln Thr Gly Arg Ser Gly Thr Gly Arg Cys 
1               5                   10      


<210>  221
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_E05

<400>  221

Cys Asp Arg Lys Ala Gly Thr Gly Arg Cys 
1               5                   10  


<210>  222
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_E11

<400>  222

Cys Ala Lys Lys Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  223
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_E12

<400>  223

Cys Ala Lys Arg Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  224
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_H04

<400>  224

Cys Pro Gln Met Thr Gly Thr Gly Arg Cys 
1               5                   10  


<210>  225
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_E01

<400>  225

Cys Asn Leu Thr Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_G10

<400>  226

Cys Glu Lys His Ser Gly Thr Gly Arg Cys 
1               5                   10  


<210>  227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_H02

<400>  227

Cys Ala Lys Arg Thr Gly Thr Gly Arg Cys 
1               5                   10  


<210>  228
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_F06

<400>  228

Cys Pro His Gln Thr Gly Thr Gly Arg Cys 
1               5                   10  


<210>  229
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_F10

<400>  229

Cys Arg Ser Leu Met Ser Gly Thr Gly Arg Cys 
1               5                   10      


<210>  230
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_F12

<400>  230

Cys Lys Ala Gln Ser Gly Ser Gly Arg Cys 
1               5                   10  


<210>  231
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_G06

<400>  231

Cys Asn Lys Ser Gly Gly Thr Gly Arg Cys 
1               5                   10  


<210>  232
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_E02

<400>  232

Cys Arg Lys Lys Ser Gly Ala Asn Arg Cys 
1               5                   10  


<210>  233
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_cMET_G08

<400>  233

Cys Ala Arg Leu Ser Gly Ser Gly Arg Cys 
1               5                   10  


<210>  234
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_F02

<400>  234

Cys Arg Thr Thr Ser Thr Ile Arg Arg Arg Cys 
1               5                   10      


<210>  235
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_G05

<400>  235

Cys Leu Asp Thr Val Asn Leu Arg Arg Arg Cys 
1               5                   10      


<210>  236
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_H03

<400>  236

Cys Asn Gln Thr Met Ser Ile Arg Arg Pro Cys 
1               5                   10      


<210>  237
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_E04

<400>  237

Cys Leu Ala Thr Thr Ser Ile Arg Arg Pro Cys 
1               5                   10      


<210>  238
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_E05

<400>  238

Cys Arg Glu Thr Ser Ser Leu Arg Arg Pro Cys 
1               5                   10      


<210>  239
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_F09

<400>  239

Cys Ile Ala Thr Ser His Ile Arg Arg His Cys 
1               5                   10      


<210>  240
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_F11

<400>  240

Cys His Glu Thr Ala Gln Ile Arg Arg Arg Cys 
1               5                   10      


<210>  241
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_H07

<400>  241

Cys Thr Gln Thr Ala Leu Ile Arg Arg Arg Cys 
1               5                   10      


<210>  242
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_H02

<400>  242

Cys Glu Gln Thr Ser Val Ile Arg Arg His Cys 
1               5                   10      


<210>  243
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_F03

<400>  243

Cys Leu Ala Thr Thr Ser Ile Arg Arg His Cys 
1               5                   10      


<210>  244
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12_B-gal_F07

<400>  244

Cys Arg Thr Thr Ala Asn Val Arg Arg His Cys 
1               5                   10      


<210>  245
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A12_ L1 (6)


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (36)..(26)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  B=T, G or C

<400>  245
acaggcagtc tgagtcctgt ttgcasnbsn bsnbsnbsnb snbgcacctc cctgcagcat       60

agatcag                                                                 67


<210>  246
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A12_L1 (8)


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  B=T, G or C

<400>  246
caggcagtct gagtcctgtt tgcasnbsnb snbsnbsnbs nbsnbsnbgc acctccctgc       60

agcatagatc ag                                                           72


<210>  247
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A12_L1 (9)


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  B=T, G or C

<400>  247
caggcagtct gagtcctgtt tgcasnbsnb snbsnbsnbs nbsnbsnbsn bgcacctccc       60

tgcagcatag atcag                                                        75


<210>  248
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A12_L1 (10)


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  B=T, G or C

<400>  248
caggcagtct gagtcctgtt tgcasnbsnb snbsnbsnbs nbsnbsnbsn bsnbgcacct       60

ccctgcagca tagatcag                                                     78


<210>  249
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_B05

<400>  249

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Asn Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Ser 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ala Pro Tyr Ser Ser Gly Trp Ala Asn Val Asp Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  250
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_B07

<400>  250

Gln Val Gln Leu Val Gln Ser Glu Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ile Thr Gly Thr Asn Gly Pro His Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  251
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_B09

<400>  251

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Ser Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Pro Tyr Tyr Asp Ser Ser Ala Asp Leu Asp Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  252
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_B11

<400>  252

Glu Val Gln Leu Val Gln Phe Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Pro Leu Ser Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  253
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_C01

<400>  253

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Tyr Ser Ser Asn 
            20                  25                  30          


Thr Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Val Leu Asp Leu Thr Asn Ser Ala Val Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Thr Ala Met Val Pro Thr Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  254
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_C03

<400>  254

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Val Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Phe Gln Arg Ser Gly Ser Tyr Pro Tyr Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  255
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_C05

<400>  255

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Tyr Ser Ser Asn 
            20                  25                  30          


Thr Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Val Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Pro Tyr Tyr Asp Ser Ser Ala Asp Leu Asp Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  256
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_C06

<400>  256

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ala Leu Arg Asp Ser Ser Gly Tyr Tyr Thr Asp Ala Leu Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  257
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_TFR_C07

<400>  257

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Pro Gly Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Pro Thr Asp 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  258
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EETI-II Cow ULVC-Ab

<400>  258
cagccggcca tggcccaagt gcaacttcgc gaaagcgggc cttccttggt taaaccatcg       60

cagaccctga gtcttacgtg cacggccagc ggtttttccc tgtccgataa agcagtaggg      120

tgggtgcgcc aagcgccggg aaaggcatta gagtggcttg gttccattga tacggggggg      180

aacacaggat acaatcccgg cttgaagtct cgcctttcaa tcaccaaaga caactcaaag      240

tctcaagtct ccctgagcgt ctcatcggtt accaccgagg actcagccac gtactactgc      300

acatccgttc atcaggagac caaaaaatac caatcttgtc cccgcatcct gatgcgttgt      360

aaacaagaca gcgactgcct ggcaggttgt gtatgcggtc ctaatgggtt ttgtggatta      420

accactctgc cagtctcata ttcttacact tataattatg agtggcatgt tgatgtctgg      480

gggcaggggc ttcttgtcac ggtctcgagt ggtggaggcg gttcaggcgg aggtggctct      540

ggcggtggcg ctagccaggc tgttttaaac caacccagct cggttagtgg atcgttgggg      600

cagcgcgtct caatcacttg ttccggctcc tcctcgaatg ttggtaatgg atatgtttcc      660

tggtaccagc ttatccccgg tagcgctcct cgcaccttaa tttatggtga cacgtcccgt      720

gccagcggtg tccctgatcg tttctctggg agccgttccg ggaacaccgc cacacttaca      780

attagtagcc ttcaagctga ggacgaagcg gactattttt gtgcctctgc agaggattca      840

tcctctaacg ctgtgtttgg cagtggcacc acccttactg tgttaggggc ggccgcagat      900


<210>  259
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2979

<400>  259
ctaagctcct gatctatgct gcaggggtct gcccgcgtat cctgatgcgt tgcaaacagg       60

actcagactg cctgg                                                        75


<210>  260
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2980

<400>  260
gaaccttgat gggactccgg agcggctccc gcagaagccg ttcggaccgc atacgcagcc       60

ggccaggcag tctgagtcct g                                                 81


<210>  261
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2983

<400>  261
ctaagctcct gatctatgct gcagggaggt gcccgcgtat cctgatgcgt tgcaaacagg       60

actcagactg cctgg                                                        75


<210>  262
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2984

<400>  262
gaatcggtca gagactccgg agttggcccc gcagaagccg ttcggaccgc atacgcagcc       60

ggccaggcag tctgagtcct g                                                 81


<210>  263
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2985

<400>  263
ttttttccat ggctgaagtc caactg                                            26


<210>  264
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2995

<400>  264
ttttttgcgg ccgcggtacg tttg                                              24


<210>  265
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2999

<400>  265
tgcagcatag atcaggagct tag                                               23


<210>  266
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3000

<400>  266
tccggagtcc catcaaggtt c                                                 21


<210>  267
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3002

<400>  267
ttttttgcgg ccgcaggctg acctag                                            26


<210>  268
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3003

<400>  268
tgcagcatag atcaggagct tag                                               23


<210>  269
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3004

<400>  269
tccggagtct ctgaccgatt c                                                 21


<210>  270
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the parental anti-TACE D1A12 scFv101

<400>  270

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Asp Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asp Phe Gly Pro Gly Tyr Gly Thr Gly Trp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile His Asp Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Phe Ser Ile Pro Leu Thr Phe Gly Gly Gly Thr Lys Met 
225                 230                 235                 240 


Asp Ile Lys Arg Thr 
                245 


<210>  271
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2965


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  S=C or G

<400>  271
gcgtcgggtt ttacctttag cvnsvnstgt ccccggatac ttatgagatg taagcaagat       60

agtgattgcc tcgc                                                         74


<210>  272
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2966


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  B=T, G or C

<400>  272
cggagcctga cgaacccasn bsnbgccaca aaacccgttg ggaccacaga cacatccggc       60

gaggcaatca ctatcttgc                                                    79


<210>  273
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2967


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  S=C or G

<400>  273
gtaaaggcct ggaatgggtc tccvnsvnst gtccccggat acttatgaga tgtaagcaag       60

atagtgattg cctcgc                                                       76


<210>  274
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2968


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  B=T, G or C

<400>  274
gtcgcgagag atggtgaaac gsnbsnbgcc acaaaacccg ttgggaccac agacacatcc       60

ggcgaggcaa tcactatctt gc                                                82


<210>  275
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2969


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  S=C or G

<400>  275
cacggctttt tattactgcg ttgatvnsvn stgtccccgg atacttatga gatgtaagca       60

agatagtgat tgcctcgc                                                     78


<210>  276
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2970


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  B=T, G or C

<400>  276
cagggtgccc ggaccccasn bsnbgccaca aaacccgttg ggaccacaga cacatccggc       60

gaggcaatca ctatcttgc                                                    79


<210>  277
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2971


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  S=C or G

<400>  277
gagacagagt caccatcact tgcvnsvnst gtccccggat acttatgaga tgtaagcaag       60

atagtgattg cctcgc                                                       76


<210>  278
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2972


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  B=T, G or C

<400>  278
cctggcttct gctgatacca snbsnbgcca caaaacccgt tgggaccaca gacacatccg       60

gcgaggcaat cactatcttg c                                                 81


<210>  279
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2973


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  S=C or G

<400>  279
ccctaagctc ctgatccatg atvnsvnstg tccccggata cttatgagat gtaagcaaga       60

tagtgattgc ctcgc                                                        75


<210>  280
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2974


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  S= C or G

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  B=T, G or C

<400>  280
ctgaaccttg atgggacccc snbsnbgcca caaaacccgt tgggaccaca gacacatccg       60

gcgaggcaat cactatcttg c                                                 81


<210>  281
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2975


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  S=C or G

<400>  281
cctgaagatt ttgcaactta ctactgtvns vnstgtcccc ggatacttat gagatgtaag       60

caagatagtg attgcctcgc                                                   80


<210>  282
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2976


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  B=T, G or C

<400>  282
cattttggtc cctccgccga asnbsnbgcc acaaaacccg ttgggaccac agacacatcc       60

ggcgaggcaa tcactatctt gc                                                82


<210>  283
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2977


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  S=C or G

<400>  283
ctaagctcct gatctatgct gcavnsvnst gcccgcgtat cctgatgcgt tgcaaacagg       60

actcagactg cctgg                                                        75


<210>  284
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2978


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  B=T, G or C

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  B=T, G or C

<400>  284
gaaccttgat gggactccgg asnbsnbccc gcagaagccg ttcggaccgc atacgcagcc       60

ggccaggcag tctgagtcct g                                                 81


<210>  285
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2981


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  S=C or G

<400>  285
ctaagctcct gatctatgct gcavnsvnst gcccgcgtat cctgatgcgt tgcaaacagg       60

actcagactg cctgg                                                        75


<210>  286
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2982

<400>  286
gaatcggtca gagactccgg agttggcccc gcagaagccg ttcggaccgc atacgcagcc       60

ggccaggcag tctgagtcct g                                                 81


<210>  287
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2986

<400>  287
gctaaaggta aaacccgacg c                                                 21


<210>  288
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2987

<400>  288
tgggttcgtc aggctccg                                                     18


<210>  289
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2988

<400>  289
ttttttctcg agacggtcac cagg                                              24


<210>  290
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2989

<400>  290
ggagacccat tccaggcctt tac                                               23


<210>  291
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2990

<400>  291
cgtttcacca tctctcgcga c                                                 21


<210>  292
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2991

<400>  292
atcaacgcag taataaaaag ccgtg                                             25


<210>  293
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2992

<400>  293
ttttttgcta gcgacatcca gatgacc                                           27


<210>  294
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2993

<400>  294
gcaagtgatg gtgactctgt ctc                                               23


<210>  295
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2994

<400>  295
tggtatcagc agaagccagg                                                   20


<210>  296
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2996

<400>  296
atcatggatc aggagcttag gg                                                22


<210>  297
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2997

<400>  297
ggggtcccat caaggttcag                                                   20


<210>  298
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2998

<400>  298
acagtagtaa gttgcaaaat cttcagg                                           27


<210>  299
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3001

<400>  299
ttttttgcta gccagtctgt gctgac                                            26


<210>  300
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3005

<400>  300
aaatttactc gagacggtca ccagggtgcc cggacccca                              39


<210>  301
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3012

<400>  301
tggggtccgg gcaccctg                                                     18


<210>  302
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EET 1-5

<400>  302

Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala 
1               5                   10                  15      


Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25      


<210>  303
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EET 2-6

<400>  303

Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn 
1               5                   10                  15      


Gly Phe Cys Gly Ser Gly Ser Asp Gly Gly Val Cys 
            20                  25              


<210>  304
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EET 3-1

<400>  304

Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
1               5                   10                  15      


Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys 
            20                  25                  


<210>  305
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EET 4-2

<400>  305

Cys Val Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly Ser Asp Gly Gly 
1               5                   10                  15      


Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys 
            20                  25                  30      


<210>  306
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EET 5-3

<400>  306

Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly Ser Asp Gly Gly Val Cys 
1               5                   10                  15      


Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly 
            20                  25                  30          


Cys 
    


<210>  307
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EET 6-4

<400>  307

Cys Gly Ser Gly Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg 
1               5                   10                  15      


Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys 
            20                  25                  


<210>  308
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C09 (9820)

<400>  308

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Gly Gly Lys Arg Cys Gly Pro Asn Gly Phe 
            20                  25                  30          


Cys Gly Ser Gly Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg 
        35                  40                  45              


Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Thr Ser Asn Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Gln Asp Asp Ser 
65                  70                  75                  80  


Val Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
                85                  90                  95      


Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Gly Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ser Ser Asp Leu Gly Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
    130                 135                 140 


<210>  309
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E01 (127988)

<400>  309

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
    50                  55                  60                  


Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
65                  70                  75                  80  


Ser Asp Cys Leu Ala Gly Cys Gly Ile His Ser Gly Val Ser Asp Arg 
                85                  90                  95      


Phe Ser Asp Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
            100                 105                 110         


Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
        115                 120                 125             


Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
    130                 135                 140                 


Gly Gln Pro 
145         


<210>  310
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E08 (121047)

<400>  310

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
    50                  55                  60                  


Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
65                  70                  75                  80  


Ser Asp Cys Leu Ala Gly Cys Gly Ile Gln Ser Gly Ile Pro Glu Arg 
                85                  90                  95      


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
            100                 105                 110         


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
        115                 120                 125             


Asn Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
    130                 135                 140                 


Gly Gln Pro 
145         


<210>  311
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E05 (118631)

<400>  311

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
    50                  55                  60                  


Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
65                  70                  75                  80  


Ser Asp Cys Leu Ala Gly Cys Gly Ala Gln Ser Gly Ile Pro Glu Arg 
                85                  90                  95      


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
            100                 105                 110         


Leu Gln Ser Glu Asp Glu Ala His Tyr Tyr Cys Ala Ala Trp Asp Asp 
        115                 120                 125             


Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
    130                 135                 140                 


Gly Gln Pro 
145         


<210>  312
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F01 (101798)

<400>  312

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Asp Ala Ala Gly Glu Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly Ser 
    50                  55                  60                  


Asp Gly Gly Val Cys Pro Arg Ile Asn Met Arg Cys Lys Gln Asp Ser 
65                  70                  75                  80  


Asp Cys Leu Ala Gly Cys Gly Arg Asp Ser Gly Val Pro Ser Arg Phe 
                85                  90                  95      


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
            100                 105                 110         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
        115                 120                 125             


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
    130                 135                 140             


<210>  313
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E03 (82495)

<400>  313

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
    50                  55                  60                  


Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
65                  70                  75                  80  


Ser Asp Cys Leu Ala Gly Cys Gly Arg Asn Ser Gly Ile Pro Glu Arg 
                85                  90                  95      


Phe Ser Gly Ser Lys Ser Gly His Thr Ala Thr Leu Thr Ile Ser Arg 
            100                 105                 110         


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
        115                 120                 125             


Ser Ser Asp His Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
    130                 135                 140                 


Gly Gln Pro 
145         


<210>  314
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F07 (72824)

<400>  314

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
    50                  55                  60                  


Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
65                  70                  75                  80  


Ser Asp Cys Leu Ala Gly Cys Gly Gly Gln Ser Gly Val Pro Asp Arg 
                85                  90                  95      


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Arg 
            100                 105                 110         


Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
        115                 120                 125             


Ser Leu Asn Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
    130                 135                 140                 


Gly Gln Pro 
145         


<210>  315
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E09 (70274)

<400>  315

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
    50                  55                  60                  


Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
65                  70                  75                  80  


Ser Asp Cys Leu Ala Gly Cys Gly Thr Gln Ser Gly Ile Pro Glu Arg 
                85                  90                  95      


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
            100                 105                 110         


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
        115                 120                 125             


Ser Leu Arg Ala Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
    130                 135                 140                 


Gly Gln Pro 
145         


<210>  316
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F03 (67972)

<400>  316

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Arg Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
    50                  55                  60                  


Gly Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
65                  70                  75                  80  


Ser Asp Cys Leu Ala Gly Cys Gly Ala His Ser Gly Ile Pro Glu Arg 
                85                  90                  95      


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
            100                 105                 110         


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
        115                 120                 125             


Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
    130                 135                 140                 


Gly Gln Pro 
145         


<210>  317
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G11 (27650)

<400>  317

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Gly Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly 
    50                  55                  60                  


Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
65                  70                  75                  80  


Ser Asp Cys Leu Ala Gly Cys Gly Gln Ser Ser Gly Val Ser Asp Arg 
                85                  90                  95      


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Asp Ile Thr Gly 
            100                 105                 110         


Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn 
        115                 120                 125             


Ser Leu Ser Val Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
    130                 135                 140                 


Gly Gln Pro 
145         


<210>  318
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3006

<400>  318
ttttttgcgg ccgcggtacg tttgatatcc attttggtcc ctccgccgaa                  50


<210>  319
<211>  219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of IGLV1-36


<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (166)..(166)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  N=A, C, G or T

<400>  319
gctagccagt ctgtgctgac tcagccaccc tcggtgtctg aagcccccag gcagagggtc       60

accatcacgt gtvnsvnsvn stgcccgcgt atcctgatgc gttgcaaaca ggactcagac      120

tgcctggccg gctgcgtatg cggtccgaac ggcttctgcg ggvnsvncaa ttggtaccag      180

cagctcccag gaaccgtcct aggtcagccc gcggccgca                             219


<210>  320
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of IGLV1-36


<220>
<221>  MISC_FEATURE
<222>  (25)..(27)
<223>  Xaa = any amino acide except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa = any amino acide except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa = one of the 12 amino acids encoded by codon VNC where N=A,C,
       G or T and V= A, C or G.

<400>  320

Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro 
1               5                   10                  15      


Arg Gln Arg Val Thr Ile Thr Cys Xaa Xaa Xaa Cys Pro Arg Ile Leu 
            20                  25                  30          


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
        35                  40                  45              


Pro Asn Gly Phe Cys Gly Xaa Xaa Asn Trp Tyr Gln Gln Leu Pro Gly 
    50                  55                  60                  


Thr Val Leu Gly Gln Pro Ala Ala Ala 
65                  70              


<210>  321
<211>  215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of IGKV1D-39


<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (166)..(166)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (169)..(169)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (170)..(170)
<223>  N=A, C, G or T

<400>  321
gctagcgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga       60

gtcaccatca cgtgtvnsvn svnstgcccg cgtatcctga tgcgttgcaa acaggactca      120

gactgcctgg ccggctgcgt atgcggtccg aacggcttct gcgggvnsvn caattggtat      180

cagcagaaac caggatcaaa cgtaccgcgg ccgca                                 215


<210>  322
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of IGKV1D-39


<220>
<221>  MISC_FEATURE
<222>  (26)..(28)
<223>  Xaa = any amino acide except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa = any amino acide except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa = one of the 12 amino acids encoded by codon VNC where N=A,C,
       G or T and V= A, C or G.

<400>  322

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Xaa Xaa Xaa Cys Pro Arg Ile 
            20                  25                  30          


Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys 
        35                  40                  45              


Gly Pro Asn Gly Phe Cys Gly Xaa Xaa Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Ile Lys Arg Thr Ala Ala Ala 
65                  70      


<210>  323
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of IGLV1-36


<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (166)..(166)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (251)..(251)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (252)..(252)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (253)..(253)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (254)..(254)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (255)..(255)
<223>  S=C or G

<400>  323
gctagccagt ctgtgctgac tcagccaccc tcggtgtctg aagcccccag gcagagggtc       60

accatcacgt gttctggaag cagctccaac atcggaaata atgctgtaaa ctggtaccag      120

cagctcccag ggaaagcccc taagctcctg atctatgctg cagnsvnstg cccgcgtatc      180

ctgatgcgtt gcaaacagga ctcagactgc ctggccggct gcgtatgcgg tccgaacggc      240

ttctgcgggv nsvnstccgg agtctctgac cgattctctg gctccaccgt cctaggtcag      300

cccgcggccg ca                                                          312


<210>  324
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of IGLV1-36


<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa = any aminno acid selected from Val, Ala, As or Gly

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa = any aminno acid except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (84)..(85)
<223>  Xaa = any aminno acid except for Cys, Tyr, Trp or Phe

<400>  324

Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro 
1               5                   10                  15      


Arg Gln Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly 
            20                  25                  30          


Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ala Ala Xaa Xaa Cys Pro Arg Ile Leu Met Arg Cys 
    50                  55                  60                  


Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly 
65                  70                  75                  80  


Phe Cys Gly Xaa Xaa Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Thr 
                85                  90                  95      


Val Leu Gly Gln Pro Ala Ala Ala 
            100                 


<210>  325
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of IGKV1D-39


<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (162)..(162)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (247)..(247)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (248)..(248)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (249)..(249)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (251)..(251)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (252)..(252)
<223>  S=C or G

<400>  325
gctagcgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga       60

gtcaccatca cgtgccgggc aagtcagagc attagcagct atttaaattg gtatcagcag      120

aaaccaggga aagcccctaa gctcctgatc tatgctgcag nsvnstgccc gcgtatcctg      180

atgcgttgca aacaggactc agactgcctg gccggctgcg tatgcggtcc gaacggcttc      240

tgcgggvnsv nstccggagt cccatcaagg ttcagtggca gtatcaaacg taccgcggcc      300

gca                                                                    303


<210>  326
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of IGKV1D-39


<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa = any amino acid selected from Val, Ala, Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa = any amino acid except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (83)..(84)
<223>  Xaa = any amino acid except for Cys, Tyr, Trp or Phe

<400>  326

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Xaa Xaa Cys Pro Arg Ile Leu Met Arg Cys Lys 
    50                  55                  60                  


Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe 
65                  70                  75                  80  


Cys Gly Xaa Xaa Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Ile Lys 
                85                  90                  95      


Arg Thr Ala Ala Ala 
            100     


<210>  327
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VH CDR1

<400>  327

Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
1               5                   10                  15      


Arg Gln Ala Pro Gly Lys Gly 
            20              


<210>  328
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into  VH CDR1


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa = randomising residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  Xaa = randomising residue

<400>  328

Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Gly 
    


<210>  329
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VH CDR2

<400>  329

Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly 
1               5                   10                  15      


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            20                  25                  30          


Asp Asn Thr 
        35  


<210>  330
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VH CDR2


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa = randomising residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  Xaa = randomising residue

<400>  330

Pro Gly Lys Gly Leu Glu Trp Val Ser Xaa Xaa Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn 
        35                  40                  45              


Thr 
    


<210>  331
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VH CDR3

<400>  331

Asp Thr Ala Phe Tyr Tyr Cys Val Asp Phe Gly Pro Gly Tyr Gly Thr 
1               5                   10                  15      


Gly Trp Phe Asp Tyr Trp Gly Pro Gly Thr Leu Val Thr Val 
            20                  25                  30  


<210>  332
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into  VH CDR3


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa = randomising residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  Xaa = randomising residue

<400>  332

Asp Thr Ala Phe Tyr Tyr Cys Val Asp Xaa Xaa Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Xaa Xaa Trp Gly Pro Gly Thr Leu Val Thr 
        35                  40                  45              


Val 
    


<210>  333
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VL CDR1

<400>  333

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
1               5                   10                  15      


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            20                  25                  


<210>  334
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VL CDR1


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa = randomising residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  Xaa = randomising residue

<400>  334

Val Gly Asp Arg Val Thr Ile Thr Cys Xaa Xaa Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala 
    


<210>  335
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VL CDR2

<400>  335

Lys Ala Pro Lys Leu Leu Ile His Asp Ala Ser Ser Leu Gln Ser Gly 
1               5                   10                  15      


Val Pro Ser Arg Phe Ser Gly Ser 
            20                  


<210>  336
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VL CDR2


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa = randomising residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  Xaa = randomising residue

<400>  336

Lys Ala Pro Lys Leu Leu Ile His Asp Xaa Xaa Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Xaa Xaa Gly Val Pro Ser Arg Phe Ser Gly 
        35                  40                  45              


Ser 
    


<210>  337
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VL CDR3

<400>  337

Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Ile Pro 
1               5                   10                  15      


Leu Thr Phe Gly Gly Gly Thr Lys Met Asp Ile 
            20                  25          


<210>  338
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VL CDR3


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa = randomising residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  Xaa = randomising residue

<400>  338

Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Xaa Xaa Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Xaa Xaa Phe Gly Gly Gly Thr Lys Met Asp 
        35                  40                  45              


Ile 
    


<210>  339
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VL CDR2

<400>  339

Ala Pro Lys Leu Leu Ile Tyr Ala Ala Gly Val Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Ser Arg Ser Gly Val Pro Ser Arg Phe Ser 
        35                  40                  45              


<210>  340
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion of EETI-II donor knottin into VL CDR2


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa = randomising residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(40)
<223>  Xaa = randomising residue

<400>  340

Ala Pro Lys Leu Leu Ile Tyr Ala Ala Xaa Xaa Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Xaa Xaa Ser Gly Val Pro Ser Arg Phe Ser 
        35                  40                  45              


<210>  341
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  knottin construct EET 5-3

<400>  341
tgcggtccga acggcttctg cggaagcggc agcgatggcg gtgtgtgccc gcgtatcctg       60

atgcgttgca aacaggactc agactgcctg gccggctgc                              99


<210>  342
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  knottin construct EET 5-3

<400>  342

Cys Gly Pro Asn Gly Phe Cys Gly Ser Gly Ser Asp Gly Gly Val Cys 
1               5                   10                  15      


Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly 
            20                  25                  30          


Cys 
    


<210>  343
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V lambda recipient domain at CDR1 before insertion of the knottin

<400>  343

Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
1               5                   10                  15      


Ala Val Asn Trp Tyr Gln Gln Leu Pro 
            20                  25  


<210>  344
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V lambda recipient domain at CDR1 after insertion of the 5-3 
       EETI-II donor


<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa represents the amino acids encoded by the codon VNC (encoding
       12 amino acids) or VNS encoding 16 amino acids in total. (V=A, C 
       or G and S=C or G)

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa can be any naturally occurring amino acid

<400>  344

Arg Val Thr Ile Thr Cys Xaa Xaa Xaa Cys Gly Pro Asn Gly Phe Cys 
1               5                   10                  15      


Gly Ser Gly Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys 
            20                  25                  30          


Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Xaa Xaa Asn Trp Tyr Gln 
        35                  40                  45              


Gln Leu Pro 
    50      


<210>  345
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V lambda recipient domain at CDR1after insertion of the 5-3 
       EETI-II donor.


<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  Xaa = any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa represents the amino acids encoded by the codon VNC (encoding
       12 amino acids) or VNS encoding 16 amino acids in total. (V=A, C 
       or G and S=C or G)

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa represents the amino acids encoded by the codon VNC (encoding
       12 amino acids) or VNS encoding 16 amino acids in total. (V=A, C 
       or G and S=C or G)

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa = any naturally occurring amino acid

<400>  345

Arg Val Thr Ile Thr Cys Gly Xaa Xaa Xaa Cys Gly Pro Asn Gly Phe 
1               5                   10                  15      


Cys Gly Ser Gly Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg 
            20                  25                  30          


Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Xaa Xaa Asn Trp Tyr 
        35                  40                  45              


Gln Gln Leu Pro 
    50          


<210>  346
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V lambda recipient domain at CDR2 before donor insertion

<400>  346

Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp 
1               5                   10                  15      


Arg Phe Ser 
            


<210>  347
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V lambda recipient domain at CDR2 after insertion of the EETI-II 
       donor


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa means any amino acid from Val, Ala, Asp, Gly or Glu

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  Xaa can be any naturally occurring amino acid

<400>  347

Lys Leu Leu Ile Tyr Ala Ala Glx Xaa Cys Gly Pro Asn Gly Phe Cys 
1               5                   10                  15      


Gly Ser Gly Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys 
            20                  25                  30          


Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Gly Xaa Xaa Ser Gly Val 
        35                  40                  45              


Ser Asp Arg Phe Ser 
    50              


<210>  348
<211>  218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of the construct arising from insertion of the 5-3 
       EETI-II knottin donor into either CDR1


<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (181)..(181)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (182)..(182)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (183)..(183)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (184)..(184)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (185)..(185)
<223>  N=A, C, G or T

<400>  348
gctagccagt ctgtgctgac tcagccaccc tcggtgtctg aagcccccag gcagagggtc       60

accatcacgt gtvnsvnsvn stgcggtccg aacggcttct gcggaagcgg cagcgatggc      120

ggtgtgtgcc cgcgtatcct gatgcgttgc aaacaggact cagactgcct ggccggctgc      180

vnsvncaatt ggtaccagca gctcccagga gcggccgc                              218


<210>  349
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of the construct arising from insertion of the 5-3 
       EETI-II knottin donor into either CDR1


<220>
<221>  MISC_FEATURE
<222>  (25)..(27)
<223>  Xaa = any amino acid except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa = any amino acid except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Xaa = one of the 12 amino acids encoded by codon VNC (where V=A, 
       C or G and N=A, C, G or T)

<400>  349

Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro 
1               5                   10                  15      


Arg Gln Arg Val Thr Ile Thr Cys Xaa Xaa Xaa Cys Gly Pro Asn Gly 
            20                  25                  30          


Phe Cys Gly Ser Gly Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met 
        35                  40                  45              


Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Xaa Xaa Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Leu Pro Gly 
65                  70  


<210>  350
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of the construct arising from insertion of the 5-3 
       EETI-II knottin donor into either CDR2 of IGLV1-36


<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (166)..(166)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (271)..(271)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (272)..(272)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (273)..(273)
<223>  S=C or G

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  V=A, C or G

<220>
<221>  misc_feature
<222>  (275)..(275)
<223>  N=A, C, G or T

<220>
<221>  misc_feature
<222>  (276)..(276)
<223>  S=C or G

<400>  350
gctagccagt ctgtgctgac tcagccaccc tcggtgtctg aagcccccag gcagagggtc       60

accatcacgt gttctggaag cagctccaac atcggaaata atgctgtaaa ctggtaccag      120

cagctcccag ggaaagcccc taagctcctg atctatgctg cagnsvnstg cggtccgaac      180

ggcttctgcg gaagcggcag cgatggcggt gtgtgcccgc gtatcctgat gcgttgcaaa      240

caggactcag actgcctggc cggctgcggg vnsvnstccg gagtctctga ccgattctct      300

ggctccaccg tcctaggtca gcccgcggcc gc                                    332


<210>  351
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of the construct arising from insertion of the 5-3 
       EETI-II knottin donor into CDR2 of IGLV1-36


<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Glx = any amino acid selected from Val, Ala, Asp, Gly or Glu

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa = any amino acid except for Cys, Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (91)..(92)
<223>  Xaa = any amino acid except for Cys, Tyr, Trp or Phe

<400>  351

Ala Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro 
1               5                   10                  15      


Arg Gln Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly 
            20                  25                  30          


Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ala Ala Glx Xaa Cys Gly Pro Asn Gly Phe Cys Gly 
    50                  55                  60                  


Ser Gly Ser Asp Gly Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys 
65                  70                  75                  80  


Gln Asp Ser Asp Cys Leu Ala Gly Cys Gly Xaa Xaa Ser Gly Val Ser 
                85                  90                  95      


Asp Arg Phe Ser Gly Ser Thr Val Leu Gly Gln Pro 
            100                 105             


<210>  352
<211>  593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of synthetic single chain Fv genes used in KnotBody 
       construction

<400>  352
gccatggctg aagtccaact ggtcgaaagc ggtggtggtc tggtgcgtcc gggcggctcc       60

ctgcgtctgt cgtgtgcggc gtcgggtttt acctttagct cttatgcgat gagctgggtt      120

cgtcaggctc cgggtaaagg cctggaatgg gtctccgcaa ttagtggttc cggcggttcg      180

acgtattacg ctgatagcgt gaaaggccgt ttcaccatct ctcgcgacaa cacgaaaaat      240

agtctgtacc tgcaaatgac ctctctgcgc gcagatgaca cggcttttta ttactgcgtt      300

gatttcggtc cgggctatgg taccggctgg tttgactact ggggtccggg caccctggtg      360

accgtctcga gtggtggagg cggttcaggc ggaggtggct ctggcggtgg cgctagccag      420

tctgtgctga ctcagccacc ctcggtgtct gaagccccca ggcagagggt caccatcacg      480

tgttctggaa gcagctccaa catcggaaat aatgctgtaa actggtacca gcagctccca      540

gggaaagccc ctaagctcct gatctatgct gcaggtgtgc tgggtgcggc cgc             593


<210>  353
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of synthetic single chain Fv genes used in KnotBody 
       construction

<400>  353

Ala Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn 
65                  70                  75                  80  


Ser Leu Tyr Leu Gln Met Thr Ser Leu Arg Ala Asp Asp Thr Ala Phe 
                85                  90                  95      


Tyr Tyr Cys Val Asp Phe Gly Pro Gly Tyr Gly Thr Gly Trp Phe Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gln Ser Val Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr 
                165                 170                 175     


Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Gly 
            180                 185                 190         


Ala Ala 
        


<210>  354
<211>  590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of synthetic single chain Fv genes used in KnotBody 
       construction

<400>  354
gccatggctg aagtccaact ggtcgaaagc ggtggtggtc tggtgcgtcc gggcggctcc       60

ctgcgtctgt cgtgtgcggc gtcgggtttt acctttagct cttatgcgat gagctgggtt      120

cgtcaggctc cgggtaaagg cctggaatgg gtctccgcaa ttagtggttc cggcggttcg      180

acgtattacg ctgatagcgt gaaaggccgt ttcaccatct ctcgcgacaa cacgaaaaat      240

agtctgtacc tgcaaatgac ctctctgcgc gcagatgaca cggcttttta ttactgcgtt      300

gatttcggtc cgggctatgg taccggctgg tttgactact ggggtccggg caccctggtg      360

accgtctcga gtggtggagg cggttcaggc ggaggtggct ctggcggtgg cgctagcgac      420

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      480

acgtgccggg caagtcagag cattagcagc tatttaaatt ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ctatgctgca ggtgtgctgg gtgcggccgc                 590


<210>  355
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of synthetic single chain Fv genes used in KnotBody 
       construction

<400>  355

Ala Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn 
65                  70                  75                  80  


Ser Leu Tyr Leu Gln Met Thr Ser Leu Arg Ala Asp Asp Thr Ala Phe 
                85                  90                  95      


Tyr Tyr Cys Val Asp Phe Gly Pro Gly Tyr Gly Thr Gly Trp Phe Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Gly Val 
            180                 185                 190         


Leu Gly Ala Ala 
        195     


<210>  356
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of knottin donor EETI-II

<400>  356
ggctgcccgc gtatcctgat gcgttgcaaa caggactcag actgcctggc cggctgcgta       60

tgcggtccga acggcttctg cggg                                              84


<210>  357
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of knottin donor EETI-II

<400>  357

Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu 
1               5                   10                  15      


Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
            20                  25              


<210>  358
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a representation of the insertion of EETI-II donor into CDR1 or 
       CDR2 of the lambda germline gene IGLV1-36

<400>  358

Arg Gln Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly 
1               5                   10                  15      


Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro 
            20                  25          


<210>  359
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a representation of the insertion of EETI-II donor into CDR1 or 
       CDR2 of the lambda germline gene IGLV1-36


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  x is a randomising residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is a randomising residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is a randomising residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa represents the amino acids encoded by the codon VNC (encoding
       12 amino acids) or VNS encoding 16 amino acids in total. (V=A, C 
       or G, N=A, C, G or T and S=C or G)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is a randomising residue

<400>  359

Arg Gln Arg Val Thr Ile Thr Cys Xaa Xaa Xaa Cys Pro Arg Ile Leu 
1               5                   10                  15      


Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly 
            20                  25                  30          


Pro Asn Gly Phe Cys Gly Xaa Xaa Asn Trp Tyr Gln Gln Leu Pro 
        35                  40                  45          


<210>  360
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  shows a representation of the insertion of EETI-II donor into 
       CDR1 or CDR2 of the lambda germline gene IGLV1-36


<220>
<221>  MISC_FEATURE
<222>  (10)..(12)
<223>  Xaa is a randomising residue

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa represents the amino acids encoded by the codon VNC (encoding
       12 amino acids) or VNS encoding 16 amino acids in total.

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa is a randomising residue

<400>  360

Arg Gln Arg Val Thr Ile Thr Cys Gly Xaa Xaa Xaa Cys Pro Arg Ile 
1               5                   10                  15      


Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys 
            20                  25                  30          


Gly Pro Asn Gly Phe Cys Gly Xaa Xaa Asn Trp Tyr Gln Gln Leu Pro 
        35                  40                  45              


<210>  361
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a representation of the insertion of EETI-II donor into CDR1 or 
       CDR2 of the lambda germline gene IGLV1-36

<400>  361

Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly 
1               5                   10                  15      


Val Ser Asp Arg Phe Ser 
            20          


<210>  362
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a representation of the insertion of EETI-II donor into CDR1 or 
       CDR2 of the lambda germline gene IGLV1-36


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Glx means any amino acid from Val, Ala, Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is a randomising residue

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is a randomising residue

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa is a randomising residue

<400>  362

Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Glx Xaa Cys Pro Arg Ile 
1               5                   10                  15      


Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Cys Val Cys 
            20                  25                  30          


Gly Pro Asn Gly Phe Cys Gly Xaa Xaa Ser Gly Val Ser Asp Arg Phe 
        35                  40                  45              


Ser 
    


<210>  363
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  363

Arg Gly Asp Leu Xaa Xaa Leu 
1               5           


<210>  364
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPTx-1_4M

<400>  364

Asp Cys Leu Gly Ala Phe Arg Lys Cys Ile Pro Asp Asn Asp Lys Cys 
1               5                   10                  15      


Cys Arg Pro Asn Leu Val Cys Ser Arg Leu His Arg Trp Cys Lys Tyr 
            20                  25                  30          


Val Phe 
        


<210>  365
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HwTx-IV 3M

<400>  365

Gly Cys Leu Gly Ile Phe Lys Ala Cys Asn Pro Ser Asn Asp Gln Cys 
1               5                   10                  15      


Cys Lys Ser Ser Lys Leu Val Cys Ser Arg Lys Thr Arg Trp Cys Lys 
            20                  25                  30          


Trp Gln Ile 
        35  


<210>  366
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProTx-III

<400>  366

Asp Cys Leu Lys Phe Gly Trp Lys Cys Asn Pro Arg Asn Asp Lys Cys 
1               5                   10                  15      


Cys Ser Gly Leu Lys Cys Gly Ser Asn His Asn Trp Cys Lys Leu His 
            20                  25                  30          


Ile 
    


<210>  367
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProTx-III 2M

<400>  367

Gly Cys Leu Lys Phe Gly Trp Lys Cys Asn Pro Arg Asn Asp Lys Cys 
1               5                   10                  15      


Cys Ser Gly Leu Lys Cys Gly Ser Asn His Asn Trp Cys Lys Trp His 
            20                  25                  30          


Ile 
    


<210>  368
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A12 ProTx-III Gly

<400>  368
ggtggcgcta gccagagtgt acttacccag cctccctcag tgtcagaggc acctagacag       60

agagtgacga ttacctgctc tgggagtagc agtaacatcg gtaacaacgc cgtcaattgg      120

taccagcaac tcccagggaa ggcccctaag cttctcattt acgcagcggg aagggactgc      180

ctcaagttcg ggtggaaatg caacccaaga aacgataaat gctgctcagg actcaagtgc      240

ggcagcaacc acaactggtg caaactccac atcggcgcaa acagtggcgt cagtgaccgc      300

ttttccgccg ccaagtctgg tacgtcagcg tctctggcaa ttaacggcct gagatcagaa      360

gacgaggcag attactactg tgccgcatgg gacgacagtc tgaatggtta cgtgtttggt      420

actggtacca agcttacggt cctcggtcaa cccgcggccg caatc                      465


<210>  369
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A12 ProTx-III 2M Gly

<400>  369
ggtggcgcta gccagagtgt acttacccag cctccctcag tgtcagaggc acctagacag       60

agagtgacga ttacctgctc tgggagtagc agtaacatcg gtaacaacgc cgtcaattgg      120

taccagcaac tcccagggaa ggcccctaag cttctcattt acgcagcggg aaggggatgc      180

ctcaagttcg ggtggaaatg caacccaaga aacgataaat gctgctcagg actcaagtgc      240

ggcagcaacc acaactggtg caaatggcac atcggcgcaa acagtggcgt cagtgaccgc      300

ttttccgccg ccaagtctgg tacgtcagcg tctctggcaa ttaacggcct gagatcagaa      360

gacgaggcag attactactg tgccgcatgg gacgacagtc tgaatggtta cgtgtttggt      420

actggtacca agcttacggt cctcggtcaa cccgcggccg caatc                      465


<210>  370
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A12 HwTx-IV 3M Gly

<400>  370
ggtggcgcta gccagagtgt cttgacgcag ccaccttctg tcagcgaggc cccacgccag       60

agggttacca taacatgttc cgggtccagc tctaacatag ggaataacgc ggtaaactgg      120

tatcagcaat tgcccggcaa agcaccgaaa ctcttgatct atgcagcggg gaggggatgc      180

ctgggaatct tcaaggcctg caaccccagc aacgaccagt gctgcaagag cagcaagctc      240

gtgtgcagca gaaagacccg gtggtgcaag tggcagatcg gcgccaacag cggcgtaagt      300

gatcgattct cagcggcgaa atccggcaca tccgcctcac tggcgatcaa cggattgcga      360

agtgaggacg aagctgacta ttattgcgcg gcctgggatg attccttgaa cgggtatgta      420

tttggcacag gaacgaagct gactgtgctg ggacaacccg cggccgcaat c               471


<210>  371
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A12 GPTx-1 4M Gly

<400>  371
ggtggcgcta gccagagtgt acttacccag cctccctcag tgtcagaggc acctagacag       60

agagtgacga ttacctgctc tgggagtagc agtaacatcg gtaacaacgc cgtcaattgg      120

taccagcaac tcccagggaa ggcccctaag cttctcattt acgcagcggg aagggattgt      180

ctcggcgcct tcagaaagtg tatacccgac aacgacaaat gttgtcgccc taacttggtc      240

tgctccagac tgcaccggtg gtgtaagtac gtgtttggtg caaacagtgg cgtcagtgac      300

cgcttttccg ccgccaagtc tggtacgtca gcgtctctgg caattaacgg cctgagatca      360

gaagacgagg cagattacta ctgtgccgca tgggacgaca gtctgaatgg ttacgtgttt      420

ggtactggta ccaagcttac ggtcctcggt caacccgcgg ccgcaatc                   468


<210>  372
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A07 VL

<400>  372

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Val Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp 
    50                  55                  60                  


Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
65                  70                  75                  80  


Ser Arg Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Gly Ala Ser Pro Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg 
    130                 135 


<210>  373
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12 VL

<400>  373

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Cys Pro Arg Ile Leu Met Arg Cys Lys Gln 
    50                  55                  60                  


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
65                  70                  75                  80  


Gly Ala Asn Ser Gly Val Ser Asp Arg Phe Ser Ala Ala Lys Ser Gly 
                85                  90                  95      


Thr Ser Ala Ser Leu Ala Ile Asn Gly Leu Arg Ser Glu Asp Glu Ala 
            100                 105                 110         


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe 
        115                 120                 125             


Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
    130                 135             


<210>  374
<211>  9771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha subunit of human Nav1.7 polypeptide

<400>  374
cggggctgct acctccacgg gcgcgccctg gcaggagggg cgcagtctgc ttgcaggcgg       60

tcgccagcgc tccagcggcg gctgtcggct ttccaattcc gccagctcgg ctgaggctgg      120

gctagcctgg gtgccagtgg ctgctagcgg caggcgtccc ctgagcaaca ggagcccaga      180

gaaaaagaag cagccctgag agagcgccgg ggaaggagag gcccgcgccc tctcctggag      240

ccagattctg caggtgcact gggtggggat gatcggcggg ctaggttgca agcctcttat      300

gtgaggagct gaagaggaat taaaatatac aggatgaaaa gatggcaatg ttgcctcccc      360

caggacctca gagctttgtc catttcacaa aacagtctct tgccctcatt gaacaacgca      420

ttgctgaaag aaaatcaaag gaacccaaag aagaaaagaa agatgatgat gaagaagccc      480

caaagccaag cagtgacttg gaagctggca aacagctgcc cttcatctat ggggacattc      540

ctcccggcat ggtgtcagag cccctggagg acttggaccc ctactatgca gacaaaaaga      600

ctttcatagt attgaacaaa gggaaaacaa tcttccgttt caatgccaca cctgctttat      660

atatgctttc tcctttcagt cctctaagaa gaatatctat taagatttta gtacactcct      720

tattcagcat gctcatcatg tgcactattc tgacaaactg catatttatg accatgaata      780

acccaccgga ctggaccaaa aatgtcgagt acacttttac tggaatatat acttttgaat      840

cacttgtaaa aatccttgca agaggcttct gtgtaggaga attcactttt cttcgtgacc      900

cgtggaactg gctggatttt gtcgtcattg tttttgcgta tttaacagaa tttgtaaacc      960

taggcaatgt ttcagctctt cgaactttca gagtattgag agctttgaaa actatttctg     1020

taatcccagg cctgaagaca attgtagggg ctttgatcca gtcagtgaag aagctttctg     1080

atgtcatgat cctgactgtg ttctgtctga gtgtgtttgc actaattgga ctacagctgt     1140

tcatgggaaa cctgaagcat aaatgttttc gaaattcact tgaaaataat gaaacattag     1200

aaagcataat gaatacccta gagagtgaag aagactttag aaaatatttt tattacttgg     1260

aaggatccaa agatgctctc ctttgtggtt tcagcacaga ttcaggtcag tgtccagagg     1320

ggtacacctg tgtgaaaatt ggcagaaacc ctgattatgg ctacacgagc tttgacactt     1380

tcagctgggc cttcttagcc ttgtttaggc taatgaccca agattactgg gaaaaccttt     1440

accaacagac gctgcgtgct gctggcaaaa cctacatgat cttctttgtc gtagtgattt     1500

tcctgggctc cttttatcta ataaacttga tcctggctgt ggttgccatg gcatatgaag     1560

aacagaacca ggcaaacatt gaagaagcta aacagaaaga attagaattt caacagatgt     1620

tagaccgtct taaaaaagag caagaagaag ctgaggcaat tgcagcggca gcggctgaat     1680

atacaagtat taggagaagc agaattatgg gcctctcaga gagttcttct gaaacatcca     1740

aactgagctc taaaagtgct aaagaaagaa gaaacagaag aaagaaaaag aatcaaaaga     1800

agctctccag tggagaggaa aagggagatg ctgagaaatt gtcgaaatca gaatcagagg     1860

acagcatcag aagaaaaagt ttccaccttg gtgtcgaagg gcataggcga gcacatgaaa     1920

agaggttgtc tacccccaat cagtcaccac tcagcattcg tggctccttg ttttctgcaa     1980

ggcgaagcag cagaacaagt ctttttagtt tcaaaggcag aggaagagat ataggatctg     2040

agactgaatt tgccgatgat gagcacagca tttttggaga caatgagagc agaaggggct     2100

cactgtttgt gccccacaga ccccaggagc gacgcagcag taacatcagc caagccagta     2160

ggtccccacc aatgctgccg gtgaacggga aaatgcacag tgctgtggac tgcaacggtg     2220

tggtctccct ggttgatgga cgctcagccc tcatgctccc caatggacag cttctgccag     2280

agggcacgac caatcaaata cacaagaaaa ggcgttgtag ttcctatctc ctttcagagg     2340

atatgctgaa tgatcccaac ctcagacaga gagcaatgag tagagcaagc atattaacaa     2400

acactgtgga agaacttgaa gagtccagac aaaaatgtcc accttggtgg tacagatttg     2460

cacacaaatt cttgatctgg aattgctctc catattggat aaaattcaaa aagtgtatct     2520

attttattgt aatggatcct tttgtagatc ttgcaattac catttgcata gttttaaaca     2580

cattatttat ggctatggaa caccacccaa tgactgagga attcaaaaat gtacttgcta     2640

taggaaattt ggtctttact ggaatctttg cagctgaaat ggtattaaaa ctgattgcca     2700

tggatccata tgagtatttc caagtaggct ggaatatttt tgacagcctt attgtgactt     2760

taagtttagt ggagctcttt ctagcagatg tggaaggatt gtcagttctg cgatcattca     2820

gactgctccg agtcttcaag ttggcaaaat cctggccaac attgaacatg ctgattaaga     2880

tcattggtaa ctcagtaggg gctctaggta acctcacctt agtgttggcc atcatcgtct     2940

tcatttttgc tgtggtcggc atgcagctct ttggtaagag ctacaaagaa tgtgtctgca     3000

agatcaatga tgactgtacg ctcccacggt ggcacatgaa cgacttcttc cactccttcc     3060

tgattgtgtt ccgcgtgctg tgtggagagt ggatagagac catgtgggac tgtatggagg     3120

tcgctggtca agctatgtgc cttattgttt acatgatggt catggtcatt ggaaacctgg     3180

tggtcctaaa cctatttctg gccttattat tgagctcatt tagttcagac aatcttacag     3240

caattgaaga agaccctgat gcaaacaacc tccagattgc agtgactaga attaaaaagg     3300

gaataaatta tgtgaaacaa accttacgtg aatttattct aaaagcattt tccaaaaagc     3360

caaagatttc cagggagata agacaagcag aagatctgaa tactaagaag gaaaactata     3420

tttctaacca tacacttgct gaaatgagca aaggtcacaa tttcctcaag gaaaaagata     3480

aaatcagtgg ttttggaagc agcgtggaca aacacttgat ggaagacagt gatggtcaat     3540

catttattca caatcccagc ctcacagtga cagtgccaat tgcacctggg gaatccgatt     3600

tggaaaatat gaatgctgag gaacttagca gtgattcgga tagtgaatac agcaaagtga     3660

gattaaaccg gtcaagctcc tcagagtgca gcacagttga taaccctttg cctggagaag     3720

gagaagaagc agaggctgaa cctatgaatt ccgatgagcc agaggcctgt ttcacagatg     3780

gttgtgtacg gaggttctca tgctgccaag ttaacataga gtcagggaaa ggaaaaatct     3840

ggtggaacat caggaaaacc tgctacaaga ttgttgaaca cagttggttt gaaagcttca     3900

ttgtcctcat gatcctgctc agcagtggtg ccctggcttt tgaagatatt tatattgaaa     3960

ggaaaaagac cattaagatt atcctggagt atgcagacaa gatcttcact tacatcttca     4020

ttctggaaat gcttctaaaa tggatagcat atggttataa aacatatttc accaatgcct     4080

ggtgttggct ggatttccta attgttgatg tttctttggt tactttagtg gcaaacactc     4140

ttggctactc agatcttggc cccattaaat cccttcggac actgagagct ttaagacctc     4200

taagagcctt atctagattt gaaggaatga gggtcgttgt gaatgcactc ataggagcaa     4260

ttccttccat catgaatgtg ctacttgtgt gtcttatatt ctggctgata ttcagcatca     4320

tgggagtaaa tttgtttgct ggcaagttct atgagtgtat taacaccaca gatgggtcac     4380

ggtttcctgc aagtcaagtt ccaaatcgtt ccgaatgttt tgcccttatg aatgttagtc     4440

aaaatgtgcg atggaaaaac ctgaaagtga actttgataa tgtcggactt ggttacctat     4500

ctctgcttca agttgcaact tttaagggat ggacgattat tatgtatgca gcagtggatt     4560

ctgttaatgt agacaagcag cccaaatatg aatatagcct ctacatgtat atttattttg     4620

tcgtctttat catctttggg tcattcttca ctttgaactt gttcattggt gtcatcatag     4680

ataatttcaa ccaacagaaa aagaagcttg gaggtcaaga catctttatg acagaagaac     4740

agaagaaata ctataatgca atgaaaaagc tggggtccaa gaagccacaa aagccaattc     4800

ctcgaccagg gaacaaaatc caaggatgta tatttgacct agtgacaaat caagcctttg     4860

atattagtat catggttctt atctgtctca acatggtaac catgatggta gaaaaggagg     4920

gtcaaagtca acatatgact gaagttttat attggataaa tgtggttttt ataatccttt     4980

tcactggaga atgtgtgcta aaactgatct ccctcagaca ctactacttc actgtaggat     5040

ggaatatttt tgattttgtg gttgtgatta tctccattgt aggtatgttt ctagctgatt     5100

tgattgaaac gtattttgtg tcccctaccc tgttccgagt gatccgtctt gccaggattg     5160

gccgaatcct acgtctagtc aaaggagcaa aggggatccg cacgctgctc tttgctttga     5220

tgatgtccct tcctgcgttg tttaacatcg gcctcctgct cttcctggtc atgttcatct     5280

acgccatctt tggaatgtcc aactttgcct atgttaaaaa ggaagatgga attaatgaca     5340

tgttcaattt tgagaccttt ggcaacagta tgatttgcct gttccaaatt acaacctctg     5400

ctggctggga tggattgcta gcacctattc ttaacagtaa gccacccgac tgtgacccaa     5460

aaaaagttca tcctggaagt tcagttgaag gagactgtgg taacccatct gttggaatat     5520

tctactttgt tagttatatc atcatatcct tcctggttgt ggtgaacatg tacattgcag     5580

tcatactgga gaattttagt gttgccactg aagaaagtac tgaacctctg agtgaggatg     5640

actttgagat gttctatgag gtttgggaga agtttgatcc cgatgcgacc cagtttatag     5700

agttctctaa actctctgat tttgcagctg ccctggatcc tcctcttctc atagcaaaac     5760

ccaacaaagt ccagctcatt gccatggatc tgcccatggt tagtggtgac cggatccatt     5820

gtcttgacat cttatttgct tttacaaagc gtgttttggg tgagagtggg gagatggatt     5880

ctcttcgttc acagatggaa gaaaggttca tgtctgcaaa tccttccaaa gtgtcctatg     5940

aacccatcac aaccacacta aaacggaaac aagaggatgt gtctgctact gtcattcagc     6000

gtgcttatag acgttaccgc ttaaggcaaa atgtcaaaaa tatatcaagt atatacataa     6060

aagatggaga cagagatgat gatttactca ataaaaaaga tatggctttt gataatgtta     6120

atgagaactc aagtccagaa aaaacagatg ccacttcatc caccacctct ccaccttcat     6180

atgatagtgt aacaaagcca gacaaagaga aatatgaaca agacagaaca gaaaaggaag     6240

acaaagggaa agacagcaag gaaagcaaaa aatagagctt catttttgat atattgttta     6300

cagcctgtga aagtgattta tttgtgttaa taaaactctt ttgaggaagt ctatgccaaa     6360

atccttttta tcaaaatatt ctcgaaggca gtgcagtcac taactctgat ttcctaagaa     6420

aggtgggcag cattagcaga tggttatttt tgcactgatg attctttaag aatcgtaaga     6480

gaactctgta ggaattattg attatagcat acaaaagtga ttcagttttt tggtttttaa     6540

taaatcagaa gaccatgtag aaaactttta catctgcctt gtcatctttt cacaggattg     6600

taattagtct tgtttcccat gtaaataaac aacacacgca tacagaaaaa tctattattt     6660

atctattatt tggaaatcaa caaaagtatt tgccttggct ttgcaatgaa atgcttgata     6720

gaagtaatgg acattagtta tgaatgttta gttaaaatgc attattaggg agcttgactt     6780

tttatcaatg tacagaggtt attctatatt ttgaggtgct taaatttatt ctacattgca     6840

tcagaaccaa tttatatgtg cctataaaat gccatgggat taaaaatata tgtaggctat     6900

tcatttctac aaatgttttt cattcatctt gactcacatg ccaacaagga taagacttac     6960

ctttagagta ttgtgtttca tagcctttct tctttcatat ccctttttgt tcatagaata     7020

accacagaac ttgaaaaatt attctaagta catattacac tcctcaaaaa aaacaaagat     7080

aactgagaaa aaagttattg acagaagttc tatttgctat tatttacata gcctaacatt     7140

tgactgtgct gcccaaaata ctgataatag tctcttaaac tcttttgtca aattttcctg     7200

ctttcttatg cagtattgtt tagtcatcct ttcgctgtaa gcaaagttga tgaaatcctt     7260

cctgatatgc agttagttgt ttgaccacgg tacatacttg agcagataat aacttgggca     7320

cagtatttat tgcatcactt gtatacaatc ccgtgtttgg caagctttca aatcatgtaa     7380

tatgacagac tttacacaga tatgtgttta gtatgaataa aaaagcattg aaatagggat     7440

tcttgccaac ttgctctctt gccaccaact tactttccta aattatggaa gtaatctttt     7500

ttggatatac ttcaatgtat acaatgagga agatgtcacc ttctccttaa aattctatga     7560

tgtgaaatat attttgcctc aatcaacaca gtaccatggg cttctaattt atcaagcaca     7620

tattcatttt gcattagctg tagacatcta gttttttgaa aacacctatt aatagtaatt     7680

tgaaaagaaa taaccataat gctttttttc gtgagtttat ttcaggaata tgagatcttt     7740

cttctataaa gttattcatg cacaggcaaa aattgagcta cacaggtaga atgtagtttt     7800

acttagaaga tttttgtggg aggttttgaa gcaaatatat aaaacaactt tcactaattt     7860

gctttccata tttaaaaaat aataaattac atttatataa taaatgttta aagcacatat     7920

tttttgttgt tctggcaatt taaaaagaaa gaggatttaa acgtacctat agaaacaaag     7980

atttatggtt aaagaatgag atcagaagtc tagaatgttt ttaaattgtg atatatttta     8040

caacatccgt tattactttg agacatttgt cctaatctac gtataaaact caatctaggg     8100

ctaaagattc tttataccat cttaggttca ttcatcttag gctatttgaa ccacttttta     8160

atttaatatg aaagacacca tgcagtgttt tccgagacta catagatcat tttatcacat     8220

acctaccaag cctgttggaa ataggttttg ataatttaag tagggaccta tacaaaatat     8280

attacattta tcagattttt aaatacattc aattaagaat ttaacatcac cttaaatttg     8340

aattcaatct accgttattt caaactcaca aatataactg cattatgaat acttacataa     8400

tgtagtaaga caagatgttt gacaggttcg tgtgtaattt tctattaatg tttttacatt     8460

gccttgtttt tatgtaaaat aaaaaatatg ggcaactggt ttgttaacaa cacaatttct     8520

tcttagcatt tcaaaaatat atataaagtt gttctttttc ctatttcatg aactatgttt     8580

ttttttaaaa taacatggtt aagttttata tatatttacg tttgtttcag gaatgtctac     8640

ttgtgacttt ttatcaatta aaaataatat ttggaagaaa gagcttatta agtataagct     8700

tgaagtaaaa ttagacctct ctttccatgt agattactgt ttgtactgat ggtttcaccc     8760

ttcagaaggc actgtcatat taatatttaa attttataat cgctgaactt attacaccca     8820

acaatacaga aaggcagtta cactgaagaa cttaacttag aataaaatgg aagcaaacag     8880

gttttctaaa aactttttta agtgaccagg tctcgctctg tcacccaggc tagagtgcaa     8940

tggcatgatc atagctctct gcagcctcaa ctctgggctc aagcaaccct cctgcctcag     9000

cctcccaagt agctaagact acaggtacat gccaccatgc ctggctaata tttaaatttt     9060

tgtagataag gggtcttgct atgttgccca ggctagtctc aaactcctgg cttcaagtgt     9120

tcctactgtc atgacctgcc aacatgctgg ggttacaggc atgagccacc atgccccaaa     9180

caggtttgaa cacaaatctt tcggatgaaa attagagaac ctaattttag ctttttgata     9240

gttacctagt ttgcaaaaga tttgggtgac ttgtgagctg tttttaaatg ctgattgttg     9300

aacatcacaa cccaaaatac ttagcatgat tttatagagt tttgatagct ttattaaaaa     9360

gagtgaaaat aaaatgcata tgtaaataaa gcagttctaa atagctattt cagagaaatg     9420

ttaatagaag tgctgaaaga agggccaact aaattaggat ggccagggaa ttggcctggg     9480

tttaggacct atgtatgaag gccaccaatt ttttaaaaat atctgtggtt tattatgtta     9540

ttatcttctt gaggaaaaca atcaagaatt gcttcatgaa aataaataaa tagccatgaa     9600

tatcataaag ctgtttacat aggattcttt acaaatttca tagatctatg aatgctcaaa     9660

atgtttgagt ttgccataaa ttatattgta gttatattgt agttatactt gagactgaca     9720

cattgtaata taatctaaga ataaaagtta tacaaaataa aaaaaaaaaa a              9771


<210>  375
<211>  1988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha subunit of human Nav1.7 amino acid sequence

<400>  375

Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Thr Arg Ile Lys Lys Gly Ile Asn  Tyr Val Lys Gln Thr  Leu Arg Glu 
        995                 1000                 1005             


Phe Ile  Leu Lys Ala Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu 
    1010                 1015                 1020             


Ile Arg  Gln Ala Glu Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile 
    1025                 1030                 1035             


Ser Asn  His Thr Leu Ala Glu  Met Ser Lys Gly His  Asn Phe Leu 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly Ser Ser  Val Asp Lys 
    1055                 1060                 1065             


His Leu  Met Glu Asp Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Ala Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Tyr Ser  Lys Val Arg Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Trp Arg Phe Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser 
    1355                 1360                 1365             


Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val Val Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1505                 1510                 1515             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Gly Gln Ser  Gln His Met Thr Glu  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1925                 1930                 1935             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


<210>  376
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7 DII S3-S4

<400>  376

Glu Leu Phe Leu Ala Asp Val Glu Gly Leu 
1               5                   10  


<210>  377
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.1 DII S3-S4

<400>  377

Glu Leu Gly Leu Ala Asn Val Glu Gly Leu 
1               5                   10  


<210>  378
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.2 DII S3-S4

<400>  378

Glu Leu Gly Leu Ala Asn Val Glu Gly Leu 
1               5                   10  


<210>  379
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.3 DII S3-S4

<400>  379

Glu Leu Gly Leu Ser Asn Val Glu Gly Leu 
1               5                   10  


<210>  380
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.6 DII S3-S4

<400>  380

Glu Leu Ser Leu Ala Asp Val Glu Gly Leu 
1               5                   10  


<210>  381
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.7 DII S1-S2

<400>  381

Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val 
1               5                   10          


<210>  382
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.1 DII S1-S2

<400>  382

Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val 
1               5                   10          


<210>  383
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.2 DII S1-S2

<400>  383

Glu His Tyr Pro Met Thr Glu Gln Phe Ser Ser Val 
1               5                   10          


<210>  384
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.3 DII S1-S2

<400>  384

Glu His Tyr Pro Met Thr Glu Gln Phe Ser Ser Val 
1               5                   10          


<210>  385
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nav1.6 DII S1-S2

<400>  385

Glu His His Pro Met Thr Pro Gln Phe Glu His Val 
1               5                   10          


<210>  386
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A07 ProTx-III 2M Gly

<400>  386

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Gly Val Gly Cys Leu Lys Phe Gly Trp Lys Cys Asn Pro 
    50                  55                  60                  


Arg Asn Asp Lys Cys Cys Ser Gly Leu Lys Cys Gly Ser Asn His Asn 
65                  70                  75                  80  


Trp Cys Lys Trp His Ile Gly Ser Arg Ser Gly Val Pro Ser Arg Phe 
                85                  90                  95      


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
            100                 105                 110         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Ser Pro 
        115                 120                 125             


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    130                 135                 140     


<210>  387
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KB_A12 ProTx-III 2M 2Gly

<400>  387

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Gly Arg Gly Cys Leu Lys Phe Gly Trp Lys Cys Asn 
    50                  55                  60                  


Pro Arg Asn Asp Lys Cys Cys Ser Gly Leu Lys Cys Gly Ser Asn His 
65                  70                  75                  80  


Asn Trp Cys Lys Trp His Ile Gly Gly Ala Asn Ser Gly Val Ser Asp 
                85                  90                  95      


Arg Phe Ser Ala Ala Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Asn 
            100                 105                 110         


Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
        115                 120                 125             


Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val 
    130                 135                 140                 


Leu Gly 
145     


<210>  388
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A07 ProTx-III 2M Gly

<400>  388
ggtggcgcta gcgacataca aatgacccaa tcacctagct ctcttagtgc ctctgttggg       60

gatcgggtca ccatcacttg tagagcgagc cagagtatct catcatactt gaactggtac      120

cagcagaagc cagggaaggc ccccaagctg ttgatttacg cggctggggt cggatgcctc      180

aagttcgggt ggaaatgcaa cccaagaaac gataaatgct gctcaggact caagtgcggc      240

agcaaccaca actggtgcaa atggcacatc ggcagccgct caggcgtgcc atcaagattt      300

agtggttcag gaagtggtac ggacttcacg ctgacgattt catctcttca acccgaagat      360

ttcgccacgt actactgtca acagggtgct tctccacctt atactttcgg tcagggtacc      420

aaggttgaga ttaagcgcac cgcggccgca atc                                   453


<210>  389
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KB_A12 ProTx-III 2M 2Gly

<400>  389
ggtggcgcta gccagagtgt acttacccag cctccctcag tgtcagaggc acctagacag       60

agagtgacga ttacctgctc tgggagtagc agtaacatcg gtaacaacgc cgtcaattgg      120

taccagcaac tcccagggaa ggcccctaag cttctcattt acgcagcggg aaggggatgc      180

ctcaagttcg ggtggaaatg caacccaaga aacgataaat gctgctcagg actcaagtgc      240

ggcagcaacc acaactggtg caaatggcac atcggcggcg caaacagtgg cgtcagtgac      300

cgcttttccg ccgccaagtc tggtacgtca gcgtctctgg caattaacgg cctgagatca      360

gaagacgagg cagattacta ctgtgccgca tgggacgaca gtctgaatgg ttacgtgttt      420

ggtactggta ccaagcttac ggtcctcggt caacccgcgg ccgcaatc                   468


