                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Modulating Biomarkers To Increase Tumor Immunity And Improve The 
       Efficacy Of Cancer Immunotherapy

<130>  DFS-187.25

<140>  PCT/US2018/042243
<141>  2018-07-16

<150>  US 62/532,594
<151>  2017-07-14

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  2679
<212>  DNA
<213>  Homo sapiens

<400>  1
gcagactcag ttctcattcc caatgggtgt cgggtttcta gagaagccaa tcagcgtcgc       60

cacgactccc gactataaag tccccatccg gactcaagaa gttctcagga ctcagaggct      120

gggatcatgg tagatggaac cctcctttta ctcctctcgg aggccctggc ccttacccag      180

acctgggcgg gctcccactc cttgaagtat ttccacactt ccgtgtcccg gcccggccgc      240

ggggagcccc gcttcatctc tgtgggctac gtggacgaca cccagttcgt gcgcttcgac      300

aacgacgccg cgagtccgag gatggtgccg cgggcgccgt ggatggagca ggaggggtca      360

gagtattggg accgggagac acggagcgcc agggacaccg cacagatttt ccgagtgaat      420

ctgcggacgc tgcgcggcta ctacaatcag agcgaggccg ggtctcacac cctgcagtgg      480

atgcatggct gcgagctggg gcccgacggg cgcttcctcc gcgggtatga acagttcgcc      540

tacgacggca aggattatct caccctgaat gaggacctgc gctcctggac cgcggtggac      600

acggcggctc agatctccga gcaaaagtca aatgatgcct ctgaggcgga gcaccagaga      660

gcctacctgg aagacacatg cgtggagtgg ctccacaaat acctggagaa ggggaaggag      720

acgctgcttc acctggagcc cccaaagaca cacgtgactc accaccccat ctctgaccat      780

gaggccaccc tgaggtgctg ggccctgggc ttctaccctg cggagatcac actgacctgg      840

cagcaggatg gggagggcca tacccaggac acggagctcg tggagaccag gcctgcaggg      900

gatggaacct tccagaagtg ggcagctgtg gtggtgcctt ctggagagga gcagagatac      960

acgtgccatg tgcagcatga ggggctaccc gagcccgtca ccctgagatg gaagccggct     1020

tcccagccca ccatccccat cgtgggcatc attgctggcc tggttctcct tggatctgtg     1080

gtctctggag ctgtggttgc tgctgtgata tggaggaaga agagctcagg tggaaaagga     1140

gggagctact ctaaggctga gtggagcgac agtgcccagg ggtctgagtc tcacagcttg     1200

taaagcctga gacagctgcc ttgtgtgcga ctgagatgca cagctgcctt gtgtgcgact     1260

gagatgcagg atttcctcac gcctccccta tgtgtcttag gggactctgg cttctctttt     1320

tgcaagggcc tctgaatctg tctgtgtccc tgttagcaca atgtgaggag gtagagaaac     1380

agtccacctc tgtgtctacc atgaccccct tcctcacact gacctgtgtt ccttccctgt     1440

tctcttttct attaaaaata agaacctggg cagagtgcgg cagctcatgc ctgtaatccc     1500

agcacttagg gaggccgagg agggcagatc acgaggtcag gagatcgaaa ccatcctggc     1560

taacacggtg aaaccccgtc tctactaaaa aatacaaaaa attagctggg cgcagaggca     1620

cgggcctgta gtcccagcta ctcaggaggc ggaggcagga gaatggcgtc aacccgggag     1680

gcggaggttg cagtgagcca ggattgtgcg actgcactcc agcctgggtg acagggtgaa     1740

acgccatctc aaaaaataaa aattgaaaaa taaaaaaaga acctggatct caatttaatt     1800

tttcatattc ttgcaatgaa atggacttga ggaagctaag atcatagcta gaaatacaga     1860

taattccaca gcacatctct agcaaattta gcctattcct attctctagc ctattcctta     1920

ccacctgtaa tcttgaccat ataccttgga gttgaatatt gttttcatac tgctgtggtt     1980

tgaatgttcc ctccaacact catgttgaga cttaatccct aatgtggcaa tactgaaagg     2040

tggggccttt gagatgtgat tggatcgtaa ggctgtgcct tcattcatgg gttaatggat     2100

taatgggtta tcacaggaat gggactggtg gctttataag aagaggaaaa gagaactgag     2160

ctagcatgcc cagcccacag agagcctcca ctagagtgat gctaagtgga aatgtgaggt     2220

gcagctgcca cagagggccc ccaccaggga aatgtctagt gtctagtgga tccaggccac     2280

aggagagagt gccttgtgga gcgctgggag caggacctga ccaccaccag gaccccagaa     2340

ctgtggagtc agtggcagca tgcagcgccc ccttgggaaa gctttaggca ccagcctgca     2400

acccattcga gcagccacgt aggctgcacc cagcaaagcc acaggcacgg ggctacctga     2460

ggccttgggg gcccaatccc tgctccagtg tgtccgtgag gcagcacacg aagtcaaaag     2520

agattattct cttcccacag ataccttttc tctcccatga ccctttaaca gcatctgctt     2580

cattcccctc accttcccag gctgatctga ggtaaacttt gaagtaaaat aaaagctgtg     2640

tttgagcatc atttgtattt caaaaaaaaa aaaaaaaaa                            2679


<210>  2
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  3
<211>  1317
<212>  DNA
<213>  Mus musculus

<400>  3
attcaggttc ctcacagacc cagggggtga ggatgttgct ttttgcccac ttgcttcagc       60

tgctggtcag cgccacagtc ccgacccaga gtagcccaca ctcgctgcgg tatttcacca      120

ccgccgtgtc ccggcccggc ctcggggagc cccggttcat cattgtcggc tacgtggacg      180

acacgcagtt cgtgcgcttc gacagcgacg cggaaaatcc gaggatggag cctcgggcgc      240

ggtggattga gcaggagggg ccggagtatt gggagcggga gacttggaaa gccagggaca      300

tggggaggaa cttcagagta aacctgagga ccctgctcgg ctactacaat cagagtaacg      360

acgaatctca cacgctgcag tggatgtacg gctgcgacgt ggggcccgat gggcgcctgc      420

tccgcgggta ttgtcaggag gcctacgatg gccaggatta catctccctg aacgaggacc      480

tgcgttcctg gaccgcgaat gacatagcct cacagatctc taagcacaag tcagaggcag      540

tcgatgaggc ccaccaacag agggcatacc tgcaaggtcc ttgcgtggag tggctccata      600

gatacctacg gctgggaaat gagacactgc agcgctcaga ccctccaaag gcacatgtga      660

cccatcaccc tagatctgaa gatgaagtca ccctgaggtg ctgggccctg ggcttctacc      720

ctgctgacat caccctgacc tggcagttga atggggagga gctgacccag gacatggagc      780

ttgtggagac caggcctgca ggggatggaa ccttccagaa gtgggcagct gtcgtggtgc      840

ctcttgggaa ggagcagtat tacacatgcc atgtgtacca tgaggggctg cctgagcccc      900

tcaccctgag atgggagcct cctccatcca ctgtctccaa catggtaatc atagctgttc      960

tggttgtcct tggagctgtg atcatccttg gagctgtggt ggcttttgtg atgaagagga     1020

ggagacacat aggtgtaaaa ggatgctatg ctcatgttct aggcagcaag agcttccaga     1080

cctctgactg gcctcagaag gcatgaaaat ccctgggggg gctggtgaga tggctcagtg     1140

ggtaagagca ctgactgctc ttctgaaggt ccagagttca aatcccagca accacatggt     1200

ggctcacaac catccgtaac gagatctgac tccctcttct ggagtgtctg aagacagcta     1260

caatgtactt acatataata aataaataaa taaataaata aataaataaa taaataa        1317


<210>  4
<211>  357
<212>  PRT
<213>  Mus musculus

<400>  4

Met Leu Leu Phe Ala His Leu Leu Gln Leu Leu Val Ser Ala Thr Val 
1               5                   10                  15      


Pro Thr Gln Ser Ser Pro His Ser Leu Arg Tyr Phe Thr Thr Ala Val 
            20                  25                  30          


Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ile Val Gly Tyr Val 
        35                  40                  45              


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg 
    50                  55                  60                  


Met Glu Pro Arg Ala Arg Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
65                  70                  75                  80  


Glu Arg Glu Thr Trp Lys Ala Arg Asp Met Gly Arg Asn Phe Arg Val 
                85                  90                  95      


Asn Leu Arg Thr Leu Leu Gly Tyr Tyr Asn Gln Ser Asn Asp Glu Ser 
            100                 105                 110         


His Thr Leu Gln Trp Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg 
        115                 120                 125             


Leu Leu Arg Gly Tyr Cys Gln Glu Ala Tyr Asp Gly Gln Asp Tyr Ile 
    130                 135                 140                 


Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Asn Asp Ile Ala Ser 
145                 150                 155                 160 


Gln Ile Ser Lys His Lys Ser Glu Ala Val Asp Glu Ala His Gln Gln 
                165                 170                 175     


Arg Ala Tyr Leu Gln Gly Pro Cys Val Glu Trp Leu His Arg Tyr Leu 
            180                 185                 190         


Arg Leu Gly Asn Glu Thr Leu Gln Arg Ser Asp Pro Pro Lys Ala His 
        195                 200                 205             


Val Thr His His Pro Arg Ser Glu Asp Glu Val Thr Leu Arg Cys Trp 
    210                 215                 220                 


Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn 
225                 230                 235                 240 


Gly Glu Glu Leu Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala 
                245                 250                 255     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly 
            260                 265                 270         


Lys Glu Gln Tyr Tyr Thr Cys His Val Tyr His Glu Gly Leu Pro Glu 
        275                 280                 285             


Pro Leu Thr Leu Arg Trp Glu Pro Pro Pro Ser Thr Val Ser Asn Met 
    290                 295                 300                 


Val Ile Ile Ala Val Leu Val Val Leu Gly Ala Val Ile Ile Leu Gly 
305                 310                 315                 320 


Ala Val Val Ala Phe Val Met Lys Arg Arg Arg His Ile Gly Val Lys 
                325                 330                 335     


Gly Cys Tyr Ala His Val Leu Gly Ser Lys Ser Phe Gln Thr Ser Asp 
            340                 345                 350         


Trp Pro Gln Lys Ala 
        355         


<210>  5
<211>  1289
<212>  DNA
<213>  Mus musculus

<400>  5
acagacccag ggagtgagga tgttgctttt tgcccacttg ctccagctgc tggtcagcgc       60

cacagtcccg acccagagta gctcacactc gctgcggtat ttccacaccg tcgtatcccg      120

gcccggcctc ggagagcccc ggttcatcat tgtcggctac gtggacgaca cgcagttcgt      180

gcgcttcgac agcgactcgg agaatccgag gatggagcct cgggcgcggt ggattgagca      240

ggaggggccg gagtattggg agcgggagac tcggaaagcc agggacatgg ggaggaactt      300

cagagtaaac ctgaggaccc tgctcggcta ctacaatcag agtaaggacg aatctcacac      360

gctgcagtgg atgtacggct gcgacgtggg gcccgatggg cgcctgctcc gcgggtattg      420

tcaggaggcc tatgatggcc aggattacat ctccctgaac gaagacctgc gctcctggac      480

cgcgaccaac ttagcctcgc atatctctaa gtgcaagtca gaggcggtcg atgaggccca      540

ccaacagagg gcatacctgc aaggtccttg cgtggagtgg ctccatacat acctacagct      600

gggaagtgag acactgctgc gctcagaccc tccaaaggca catgtgaccc gtcaccccag      660

acctgaaggt gatgtcaccc tgaggtgctg ggccctgggc ttctatcctg ctgacatcac      720

cctgacctgg cagttgaatg gggaggagct gacccaggac atggagtttg tggagaccag      780

gcctgcaggg gatggaacct tccagaagtg ggcatctgtg gtggtgcctc ttgggaagga      840

gcagaattac acatgccatg tgtaccatga ggggctgcct gagcccctca ccctgagatg      900

ggagcctcct ccatccactg tctccaacat ggtaatcatt gctgttctgg ttgtccttgg      960

agctgtgata gtcattgttg ctgtggtggc ttttgtaatg aagaggagga aaacacaggt     1020

gtaaaaggat gctatgctca tgttctaggc agcaagagct tccagacctc tgactggcct     1080

cagaaggcat gacaatccct gggggcctgg gactggacct gaggcacaag ggagaccggg     1140

gttcaattcc tagcactgac atggcaggtg tctgttacta gtaacaaaca gttcatgtct     1200

catgaatgta gacatgaatg cagctaaagc accaacatac ataatattaa acctttaaaa     1260

aaataaaagg tgtatgagct ggacaaaca                                       1289


<210>  6
<211>  334
<212>  PRT
<213>  Mus musculus

<400>  6

Met Leu Leu Phe Ala His Leu Leu Gln Leu Leu Val Ser Ala Thr Val 
1               5                   10                  15      


Pro Thr Gln Ser Ser Ser His Ser Leu Arg Tyr Phe His Thr Val Val 
            20                  25                  30          


Ser Arg Pro Gly Leu Gly Glu Pro Arg Phe Ile Ile Val Gly Tyr Val 
        35                  40                  45              


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Glu Asn Pro Arg 
    50                  55                  60                  


Met Glu Pro Arg Ala Arg Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
65                  70                  75                  80  


Glu Arg Glu Thr Arg Lys Ala Arg Asp Met Gly Arg Asn Phe Arg Val 
                85                  90                  95      


Asn Leu Arg Thr Leu Leu Gly Tyr Tyr Asn Gln Ser Lys Asp Glu Ser 
            100                 105                 110         


His Thr Leu Gln Trp Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg 
        115                 120                 125             


Leu Leu Arg Gly Tyr Cys Gln Glu Ala Tyr Asp Gly Gln Asp Tyr Ile 
    130                 135                 140                 


Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Thr Asn Leu Ala Ser 
145                 150                 155                 160 


His Ile Ser Lys Cys Lys Ser Glu Ala Val Asp Glu Ala His Gln Gln 
                165                 170                 175     


Arg Ala Tyr Leu Gln Gly Pro Cys Val Glu Trp Leu His Thr Tyr Leu 
            180                 185                 190         


Gln Leu Gly Ser Glu Thr Leu Leu Arg Ser Asp Pro Pro Lys Ala His 
        195                 200                 205             


Val Thr Arg His Pro Arg Pro Glu Gly Asp Val Thr Leu Arg Cys Trp 
    210                 215                 220                 


Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn 
225                 230                 235                 240 


Gly Glu Glu Leu Thr Gln Asp Met Glu Phe Val Glu Thr Arg Pro Ala 
                245                 250                 255     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly 
            260                 265                 270         


Lys Glu Gln Asn Tyr Thr Cys His Val Tyr His Glu Gly Leu Pro Glu 
        275                 280                 285             


Pro Leu Thr Leu Arg Trp Glu Pro Pro Pro Ser Thr Val Ser Asn Met 
    290                 295                 300                 


Val Ile Ile Ala Val Leu Val Val Leu Gly Ala Val Ile Val Ile Val 
305                 310                 315                 320 


Ala Val Val Ala Phe Val Met Lys Arg Arg Lys Thr Gln Val 
                325                 330                 


<210>  7
<211>  3060
<212>  DNA
<213>  Homo sapiens

<400>  7
gccgggtttg ggggttggga cctccggctg caggtccgcc tgggccagac gcgcgagcgc       60

aagcagcggg ttagtggtcg cgcgcccgac ctccgcagtc ccagccgagc cgcgaccctt      120

ccggccgtcc ccaccccacc tcgccgccat gcgcctccgc cgcctagcgc tgttcccggg      180

tgtggcgctg cttcttgccg cggcccgcct cgccgctgcc tccgacgtgc tagaactcac      240

ggacgacaac ttcgagagtc gcatctccga cacgggctct gcgggcctca tgctcgtcga      300

gttcttcgcc ccctggtgtg gacactgcaa gagacttgca cctgagtatg aagctgcagc      360

taccagatta aaaggaatag tcccattagc aaaggttgat tgcactgcca acactaacac      420

ctgtaataaa tatggagtca gtggatatcc aaccctgaag atatttagag atggtgaaga      480

agcaggtgct tatgatggac ctaggactgc tgatggaatt gtcagccact tgaagaagca      540

ggcaggacca gcttcagtgc ctctcaggac tgaggaagaa tttaagaaat tcattagtga      600

taaagatgcc tctatagtag gttttttcga tgattcattc agtgaggctc actccgagtt      660

cctaaaagca gccagcaact tgagggataa ctaccgattt gcacatacga atgttgagtc      720

tctggtgaac gagtatgatg ataatggaga gggtatcatc ttatttcgtc cttcacatct      780

cactaacaag tttgaggaca agactgtggc atatacagag caaaaaatga ccagtggcaa      840

aattaaaaag tttatccagg aaaacatttt tggtatctgc cctcacatga cagaagacaa      900

taaagatttg atacagggca aggacttact tattgcttac tatgatgtgg actatgaaaa      960

gaacgctaaa ggttccaact actggagaaa cagggtaatg atggtggcaa agaaattcct     1020

ggatgctggg cacaaactca actttgctgt agctagccgc aaaaccttta gccatgaact     1080

ttctgatttt ggcttggaga gcactgctgg agagattcct gttgttgcta tcagaactgc     1140

taaaggagag aagtttgtca tgcaggagga gttctcgcgt gatgggaagg ctctggagag     1200

gttcctgcag gattactttg atggcaatct gaagagatac ctgaagtctg aacctatccc     1260

agagagcaat gatgggcctg tgaaggtagt ggtagcagag aattttgatg aaatagtgaa     1320

taatgaaaat aaagatgtgc tgattgaatt ttatgcccct tggtgtggtc actgtaagaa     1380

cctggagccc aagtataaag aacttggcga gaagctcagc aaagacccaa atatcgtcat     1440

agccaagatg gatgccacag ccaatgatgt gccttctcca tatgaagtca gaggttttcc     1500

taccatatac ttctctccag ccaacaagaa gctaaatcca aagaaatatg aaggtggccg     1560

tgaattaagt gattttatta gctatctaca aagagaagct acaaaccccc ctgtaattca     1620

agaagaaaaa cccaagaaga agaagaaggc acaggaggat ctctaaagca gtagccaaac     1680

accactttgt aaaaggactc ttccatcaga gatgggaaaa ccattgggga ggactaggac     1740

ccatatggga attattacct ctcagggccg agaggacaga atggatataa tctgaatcct     1800

gttaaatttt ctctaaactg tttcttagct gcactgttta tggaaatacc aggaccagtt     1860

tatgtttgtg gttttgggaa aaattatttg tgttggggga aatgttgtgg gggtggggtt     1920

gagttggggg tattttctaa ttttttttgt acatttggaa cagtgacaat aaatgagacc     1980

cctttaaact gtcttatttt ccaccagatt gagaaccaga tgttctctac acactatcac     2040

tgttcaatag agctttcttc agtgatggaa atgctctgta atctacactg ttcagtacag     2100

gtagctacgg agcatctgaa atatggctag aaactacatt tttgttttga ttaatttaaa     2160

tagccataca gttgctacca tactggtcac ggcagctgta gactgactgg gtccatagtt     2220

catcacctca aaattctttc aaaatttatt atctctttct ctccttacat gtttatttcc     2280

caggcctacc ctggtgatta gaacagctga agggcctttc ttgttaggct gtccatgccc     2340

taaggatggg ttcctgttta tccttgccac gcagctgagc ttactgcatg tttatatctc     2400

ccaaggactg ttctctgctc agaaatgccc tgtcaagggt gtggcatcac gcagtttcat     2460

ccaagttgtt tcaggaattg ctgacactgc tgggtgcagt tctatcccct aaagcctagg     2520

gtgtggccct ttaacttccc cttcagtaga actgggaaag gcagtaccat tcctagttat     2580

gagtgaagca tccactttct tttgtaacaa tgaggaacag aaaggataag actgaagagt     2640

gatcttttgt ccaactaaac catttatctc cttttgtagg taaattcaaa tcctgcccag     2700

ttatagtttt cagtcactgg agaattccag gtaggagccc tactttaggt gatcctagga     2760

actcctatgt tcagaaaaga attttcttcc tactatataa ttacagtatt tagctgtcaa     2820

ttttaagatg aatttggtag agccttatag taaagtatgt atcttggtca cacacaaagc     2880

ttggaaaaag taaaagatgt ctaaaccata atcttgtaac tcataacatc tgggctgggg     2940

cccggggatc taattgttta gagagcccca aaagtggctc agatgtaaag ccagggttaa     3000

gaaccatctg ccttggaaga tttaagggaa acatataaac ttgtacaaag gacaaaaaaa     3060


<210>  8
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  9
<211>  2658
<212>  DNA
<213>  Mus musculus

<400>  9
cgagcaggcc tagggggttg ggacctcggc agcgggtctg cccgggccag acgcgcgagc       60

gcaggcaagc ggctgcagat tgcgggctct cccatctcat ttctccggtc ccggccctcc      120

gaccgcgacc cgccgccatg cgcttcagct gcctagctct gctcccgggc gtggcgctgc      180

tgctcgcctc ggcccgtctc gccgccgcct ccgatgtgtt ggaactgacg gacgaaaact      240

tcgagagtcg cgtctccgac acgggctcgg cggggctcat gctagtcgag ttcttcgccc      300

cctggtgtgg acattgcaag aggcttgccc ctgagtatga agctgcagca accagattaa      360

aaggaatagt cccattagca aaggtggatt gcactgccaa cacaaacacc tgtaataagt      420

atggggtcag tggctaccca actcttaaga tctttagaga tggtgaagaa gcgggtgctt      480

atgatgggcc taggactgct gatggaattg tcagccactt gaagaaacaa gcaggaccag      540

cttcagttcc tctcaggact gaggaagaat ttaagaagtt cattagtgat aaagatgcct      600

cagtggtggg ttttttcagg gatttattca gtgatgggca ctctgaattc ctaaaagcag      660

ccagcaactt gagagataac taccgatttg cacacaccaa cattgagtct ctggtgaagg      720

agtacgatga taatggagag gggatcacta tattccgtcc attacatctt gctaacaagt      780

ttgaagacaa aactgtggca tatactgaaa agaaaatgac cagtggcaag atcaagaaat      840

ttattcagga tagcattttt ggtctctgtc ctcatatgac ggaagataat aaagatttga      900

tacaaggcaa ggacttactc accgcttact atgatgtgga ctatgaaaag aatgctaaag      960

gttctaacta ctggagaaac agggtcatga tggtggcaaa gaaattcctt gatgctggac     1020

acaaactcaa ctttgctgta gctagccgta aaacctttag ccatgaactg tcagattttg     1080

gcttagaaag cactactgga gaggttcctg ttgtggctat cagaactgct aaaggagaga     1140

agtttgtcat gcaggaggag ttctcgcgag atggcaaggc tcttgaacag ttcctgcaag     1200

aatactttga tggcaacttg aagagatacc tgaagtctga acccatccca gagtccaacg     1260

aagggcctgt caaggttgtg gtagcagaga attttgatga catagtgaat gaagaagata     1320

aggacgtgct gattgaattt tacgcccctt ggtgtggcca ctgtaagaat ctggaaccca     1380

agtataaaga gctgggagaa aaactcagca aagatccaaa tattgtcata gccaagatgg     1440

atgccacagc caatgatgtg ccttctccat atgaagtcaa gggttttcct accatctact     1500

tctcaccagc caacaagaag ctaactccaa agaagtatga aggtggccgt gaattaaatg     1560

attttattag ctatctacaa cgagaagcta caaacccccc tataattcaa gaagaaaaac     1620

ctaagaagaa gaagaaggca caagaggacc tctaaagcaa cagccaaatg caccacttta     1680

taaaaggact cttacaccag agaaggcaaa accagagagg acagaatgga tatactctga     1740

atcctgttaa attttctcta aactgtttct tagctgcact gtttgaaaat acaaggacca     1800

gtttatgttt gtggttttgg gagaaaatta tttgtgttgg gaagaatgtt gtgggggtgg     1860

ggggaattga gttggggggt tattttctaa ttttttttgt acatttggaa cagtgacaat     1920

aaatgtgccc cctttatact gtcgtttttt tcccctcatg ggatggagaa tcagggtctc     1980

taaactgtaa tacagtaata gatagaagtg tttgagctat gctgttcaat gctgtagcta     2040

aaccagatat gttatctcct ataatcgcaa cacttgggag gtgcaggcaa gagatctcaa     2100

gttcaagatc ttccatggct acatagcagg ttttgaggct agcatcttaa acaggtttga     2160

tctttcaaaa acaaagaaaa ccagctatgc tgattcctgt aacttgagac tgaataggtc     2220

cagttaccat ctccaaattg tataatttat tagtttcttt ctgtagctca agctgtcctt     2280

gaacttgtga tggtctccct ccctggccct gagatactga gatgacagtt gtttctagcc     2340

tcattcatgt cctaaaggtg aatgcttact cttgccacac agccaagctt tctgcatgtg     2400

catgcctcct gaggatggtt ctctgcccag aaatgccctg tgtgagtgac agcagtttgg     2460

ggttccatcc aattttagga attattgaaa ctgctgggtg cagctctccc caaatcattg     2520

ggtgtagcca tttacttccc tccagtgaac agggaaacag tatcaatcgc tggcaagaac     2580

aagaacccac agagatgttt tcttttgaat ggattaaagt attgccctcc ttttatagct     2640

aaaaaaaaaa aaaaaaaa                                                   2658


<210>  10
<211>  505
<212>  PRT
<213>  Mus musculus

<400>  10

Met Arg Phe Ser Cys Leu Ala Leu Leu Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Glu Asn Phe Glu Ser Arg Val Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Val Val Gly Phe Phe 
145                 150                 155                 160 


Arg Asp Leu Phe Ser Asp Gly His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Ile Glu Ser Leu 
            180                 185                 190         


Val Lys Glu Tyr Asp Asp Asn Gly Glu Gly Ile Thr Ile Phe Arg Pro 
        195                 200                 205             


Leu His Leu Ala Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Lys Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Asp Ser Ile 
225                 230                 235                 240 


Phe Gly Leu Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Thr Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Thr 
305                 310                 315                 320 


Gly Glu Val Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Gln Phe 
            340                 345                 350         


Leu Gln Glu Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Glu Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Asp Ile Val Asn Glu Glu Asp Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Lys 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Thr Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Asn Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Ile Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  11
<211>  1929
<212>  DNA
<213>  Homo sapiens

<400>  11
gcggcgtccg tccgtactgc agagccgctg ccggagggtc gttttaaagg gcccgcgcgt       60

tgccgccccc tcggcccgcc atgctgctat ccgtgccgct gctgctcggc ctcctcggcc      120

tggccgtcgc cgagcctgcc gtctacttca aggagcagtt tctggacgga gacgggtgga      180

cttcccgctg gatcgaatcc aaacacaagt cagattttgg caaattcgtt ctcagttccg      240

gcaagttcta cggtgacgag gagaaagata aaggtttgca gacaagccag gatgcacgct      300

tttatgctct gtcggccagt ttcgagcctt tcagcaacaa aggccagacg ctggtggtgc      360

agttcacggt gaaacatgag cagaacatcg actgtggggg cggctatgtg aagctgtttc      420

ctaatagttt ggaccagaca gacatgcacg gagactcaga atacaacatc atgtttggtc      480

ccgacatctg tggccctggc accaagaagg ttcatgtcat cttcaactac aagggcaaga      540

acgtgctgat caacaaggac atccgttgca aggatgatga gtttacacac ctgtacacac      600

tgattgtgcg gccagacaac acctatgagg tgaagattga caacagccag gtggagtccg      660

gctccttgga agacgattgg gacttcctgc cacccaagaa gataaaggat cctgatgctt      720

caaaaccgga agactgggat gagcgggcca agatcgatga tcccacagac tccaagcctg      780

aggactggga caagcccgag catatccctg accctgatgc taagaagccc gaggactggg      840

atgaagagat ggacggagag tgggaacccc cagtgattca gaaccctgag tacaagggtg      900

agtggaagcc ccggcagatc gacaacccag attacaaggg cacttggatc cacccagaaa      960

ttgacaaccc cgagtattct cccgatccca gtatctatgc ctatgataac tttggcgtgc     1020

tgggcctgga cctctggcag gtcaagtctg gcaccatctt tgacaacttc ctcatcacca     1080

acgatgaggc atacgctgag gagtttggca acgagacgtg gggcgtaaca aaggcagcag     1140

agaaacaaat gaaggacaaa caggacgagg agcagaggct taaggaggag gaagaagaca     1200

agaaacgcaa agaggaggag gaggcagagg acaaggagga tgatgaggac aaagatgagg     1260

atgaggagga tgaggaggac aaggaggaag atgaggagga agatgtcccc ggccaggcca     1320

aggacgagct gtagagaggc ctgcctccag ggctggactg aggcctgagc gctcctgccg     1380

cagagctggc cgcgccaaat aatgtctctg tgagactcga gaactttcat ttttttccag     1440

gctggttcgg atttggggtg gattttggtt ttgttcccct cctccactct cccccacccc     1500

ctccccgccc tttttttttt ttttttttaa actggtattt tatctttgat tctccttcag     1560

ccctcacccc tggttctcat ctttcttgat caacatcttt tcttgcctct gtccccttct     1620

ctcatctctt agctcccctc caacctgggg ggcagtggtg tggagaagcc acaggcctga     1680

gatttcatct gctctccttc ctggagccca gaggagggca gcagaagggg gtggtgtctc     1740

caacccccca gcactgagga agaacggggc tcttctcatt tcacccctcc ctttctcccc     1800

tgcccccagg actgggccac ttctgggtgg ggcagtgggt cccagattgg ctcacactga     1860

gaatgtaaga actacaaaca aaatttctat taaattaaat tttgtgtctc caaaaaaaaa     1920

aaaaaaaaa                                                             1929


<210>  12
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210>  13
<211>  1943
<212>  DNA
<213>  Mus musculus

<400>  13
ggctgtgtca ggttcgggtg agaggtaggt gaatataaat tgaagcggcg gtggccgcgt       60

ccgtcaatac cgcagagccg ctgcctgaag atcgtcttaa aaggcctgtg tgccgccgcc      120

ccctcggccc gccatgctcc tttcggtgcc gctcctgctt ggcctcctcg gcctggccgc      180

cgcagaccct gccatctatt tcaaagagca gttcttggac ggagatgcct ggaccaaccg      240

ctgggtcgaa tccaaacata agtccgattt tggcaaattt gtcctcagtt ctggcaaatt      300

ttacggggac ctggagaagg ataaagggct gcagacaagc caagatgccc gattttacgc      360

actgtccgcc aaattcgaac ccttcagcaa taagggccag acactggtgg tacagttcac      420

ggtgaagcat gagcagaata tcgactgtgg gggcggctac gtgaagctgt ttccgagtgg      480

tttggaccag aaggacatgc atggagactc agaatataac atcatgtttg gtccggacat      540

ctgcggtcct ggcaccaaga aggttcatgt catctttaac tacaagggca agaatgtgct      600

gatcaacaag gatatccggt gtaaggatga tgaattcaca cacctataca cactgattgt      660

gcggccagac aacacctatg aggtgaaaat tgacaacagc caggtggagt caggctcctt      720

ggaggatgat tgggactttc tgccacccaa gaagataaag gaccctgatg ctgccaagcc      780

ggaagactgg gatgaacgag ccaagatcga tgaccccaca gattccaagc ctgaggactg      840

ggacaagcca gagcacatcc ctgaccctga tgctaagaag cctgaggact gggatgaaga      900

gatggatgga gagtgggaac caccagtgat tcaaaatcct gaatacaagg gcgagtggaa      960

accacgtcaa attgacaacc cagattacaa gggtacctgg atacacccag aaattgacaa     1020

ccctgaatac tcccccgatg caaatatcta tgcctatgat agttttgctg tactgggcct     1080

agatctctgg caggtcaagt ccgggacaat ctttgacaat ttcctcatca ccaatgatga     1140

ggcctatgca gaggagtttg gcaatgagac gtggggtgtt accaaggctg cagagaagca     1200

gatgaaggac aagcaggatg aggagcagag gcttaaggaa gaagaagagg acaagaagcg     1260

taaagaggaa gaagaagctg aggataaaga ggatgatgat gacagagatg aagatgagga     1320

cgaagaagat gagaaggagg aagatgagga agaatcccct ggccaagcca aggatgagct     1380

gtagaggcca caccacctgc cttcagggct ggactgaggc ctgaacaccc tgccgcagag     1440

ctggctgctc ccaataatgt ctctatgaga ctcaagaact tttcattttt tccaggcagg     1500

ttcagatctg gggtagattc tgattttgtt cccctgcctc ccccattacc cccccccctt     1560

ttttttttta ctggtgtttg tctttaattc tccttcagcc ctcatctggt ttctcatttt     1620

tgaatcaaca tcttttcctt ctgtccctcc ctttctccat cttttggtca ctaccctcca     1680

actctaggaa caggggtgta gaggagaagc cctaggcttg agatttcatc tgctctcctt     1740

cctgcatctc agaggagggc aggagaaggg ggtggtgttt tccctccccc cgcactgagg     1800

aagaatgggg ctcttctcat cccctttctc ccttgccccc aggactgggc cacttgtggg     1860

gcagccagtt ctagcacagc tcacactgag agtgtaagaa ctacaaacaa aatttctatt     1920

aaattaagtt ttgtgtcttc cct                                             1943


<210>  14
<211>  416
<212>  PRT
<213>  Mus musculus

<400>  14

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Ala 
1               5                   10                  15      


Ala Asp Pro Ala Ile Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Ala 
            20                  25                  30          


Trp Thr Asn Arg Trp Val Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Leu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Lys 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Ser Gly Leu Asp Gln Lys Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ala Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Ala Asn 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Ser Phe Ala Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Asp Asp Arg Asp Glu Asp Glu Asp Glu Glu Asp Glu 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Ser Pro Gly Gln Ala Lys Asp Glu Leu 
                405                 410                 415     


<210>  15
<211>  2974
<212>  DNA
<213>  Homo sapiens

<400>  15
gtgtgcgtga tggagaaaat tgggcaccag ggctgctccc gagattctca gatctgattt       60

ccacgcttgc taccaaaata gtctgggcag gccacttttg gaagtaggcg ttatctagtg      120

agcaggcggc cgctttcgat ttcgctttcc cctaaatggc tgagcttctc gccagcgcag      180

gatcagcctg ttcctgggac tttccgagag ccccgccctc gttccctccc ccagccgcca      240

gtaggggagg actcggcggt acccggagct tcaggcccca ccggggcgcg gagagtccca      300

ggcccggccg ggaccgggac ggcgtccgag tgccaatggc tagctctagg tgtcccgctc      360

cccgcgggtg ccgctgcctc cccggagctt ctctcgcatg gctggggaca gtactgctac      420

ttctcgccga ctgggtgctg ctccggaccg cgctgccccg catattctcc ctgctggtgc      480

ccaccgcgct gccactgctc cgggtctggg cggtgggcct gagccgctgg gccgtgctct      540

ggctgggggc ctgcggggtc ctcagggcaa cggttggctc caagagcgaa aacgcaggtg      600

cccagggctg gctggctgct ttgaagccat tagctgcggc actgggcttg gccctgccgg      660

gacttgcctt gttccgagag ctgatctcat ggggagcccc cgggtccgcg gatagcacca      720

ggctactgca ctggggaagt caccctaccg ccttcgttgt cagttatgca gcggcactgc      780

ccgcagcagc cctgtggcac aaactcggga gcctctgggt gcccggcggt cagggcggct      840

ctggaaaccc tgtgcgtcgg cttctaggct gcctgggctc ggagacgcgc cgcctctcgc      900

tgttcctggt cctggtggtc ctctcctctc ttggggagat ggccattcca ttctttacgg      960

gccgcctcac tgactggatt ctacaagatg gctcagccga taccttcact cgaaacttaa     1020

ctctcatgtc cattctcacc atagccagtg cagtgctgga gttcgtgggt gacgggatct     1080

ataacaacac catgggccac gtgcacagcc acttgcaggg agaggtgttt ggggctgtcc     1140

tgcgccagga gacggagttt ttccaacaga accagacagg taacatcatg tctcgggtaa     1200

cagaggacac gtccaccctg agtgattctc tgagtgagaa tctgagctta tttctgtggt     1260

acctggtgcg aggcctatgt ctcttgggga tcatgctctg gggatcagtg tccctcacca     1320

tggtcaccct gatcaccctg cctctgcttt tccttctgcc caagaaggtg ggaaaatggt     1380

accagttgct ggaagtgcag gtgcgggaat ctctggcaaa gtccagccag gtggccattg     1440

aggctctgtc ggccatgcct acagttcgaa gctttgccaa cgaggagggc gaagcccaga     1500

agtttaggga aaagctgcaa gaaataaaga cactcaacca gaaggaggct gtggcctatg     1560

cagtcaactc ctggaccact agtatttcag gtatgctgct gaaagtggga atcctctaca     1620

ttggtgggca gctggtgacc agtggggctg taagcagtgg gaaccttgtc acatttgttc     1680

tctaccagat gcagttcacc caggctgtgg aggtactgct ctccatctac cccagagtac     1740

agaaggctgt gggctcctca gagaaaatat ttgagtacct ggaccgcacc cctcgctgcc     1800

cacccagtgg tctgttgact cccttacact tggagggcct tgtccagttc caagatgtct     1860

cctttgccta cccaaaccgc ccagatgtct tagtgctaca ggggctgaca ttcaccctac     1920

gccctggcga ggtgacggcg ctggtgggac ccaatgggtc tgggaagagc acagtggctg     1980

ccctgctgca gaatctgtac cagcccaccg ggggacagct gctgttggat gggaagcccc     2040

ttccccaata tgagcaccgc tacctgcaca ggcaggtggc tgcagtggga caagagccac     2100

aggtatttgg aagaagtctt caagaaaata ttgcctatgg cctgacccag aagccaacta     2160

tggaggaaat cacagctgct gcagtaaagt ctggggccca tagtttcatc tctggactcc     2220

ctcagggcta tgacacagag gtagacgagg ctgggagcca gctgtcaggg ggtcagcgac     2280

aggcagtggc gttggcccga gcattgatcc ggaaaccgtg tgtacttatc ctggatgatg     2340

ccaccagtgc cctggatgca aacagccagt tacaggtgga gcagctcctg tacgaaagcc     2400

ctgagcggta ctcccgctca gtgcttctca tcacccagca cctcagcctg gtggagcagg     2460

ctgaccacat cctctttctg gaaggaggcg ctatccggga ggggggaacc caccagcagc     2520

tcatggagaa aaaggggtgc tactgggcca tggtgcaggc tcctgcagat gctccagaat     2580

gaaagccttc tcagacctgc gcactccatc tccctccctt ttcttctctc tgtggtggag     2640

aaccacagct gcagagtagg cagctgcctc caggatgagt tacttgaaat ttgccttgag     2700

tgtgttacct cctttccaag ctcctcgtga taatgcagac ttcctggagt acaaacacag     2760

gatttgtaat tccttactgt aacggagttt agagccaggg ctgatgcttt ggtgtggcca     2820

gcactctgaa actgagaaat gttcagaatg tacggaaaga tgatcagcta ttttcaacat     2880

aactgaaggc atatgctggc ccataaacac cctgtaggtt cttgatattt ataataaaat     2940

tggtgttttg taaaaaaaaa aaaaaaaaaa aaaa                                 2974


<210>  16
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Glu Leu Leu Ala Ser Ala Gly Ser Ala Cys Ser Trp Asp Phe 
1               5                   10                  15      


Pro Arg Ala Pro Pro Ser Phe Pro Pro Pro Ala Ala Ser Arg Gly Gly 
            20                  25                  30          


Leu Gly Gly Thr Arg Ser Phe Arg Pro His Arg Gly Ala Glu Ser Pro 
        35                  40                  45              


Arg Pro Gly Arg Asp Arg Asp Gly Val Arg Val Pro Met Ala Ser Ser 
    50                  55                  60                  


Arg Cys Pro Ala Pro Arg Gly Cys Arg Cys Leu Pro Gly Ala Ser Leu 
65                  70                  75                  80  


Ala Trp Leu Gly Thr Val Leu Leu Leu Leu Ala Asp Trp Val Leu Leu 
                85                  90                  95      


Arg Thr Ala Leu Pro Arg Ile Phe Ser Leu Leu Val Pro Thr Ala Leu 
            100                 105                 110         


Pro Leu Leu Arg Val Trp Ala Val Gly Leu Ser Arg Trp Ala Val Leu 
        115                 120                 125             


Trp Leu Gly Ala Cys Gly Val Leu Arg Ala Thr Val Gly Ser Lys Ser 
    130                 135                 140                 


Glu Asn Ala Gly Ala Gln Gly Trp Leu Ala Ala Leu Lys Pro Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Gly Leu Ala Leu Pro Gly Leu Ala Leu Phe Arg Glu Leu 
                165                 170                 175     


Ile Ser Trp Gly Ala Pro Gly Ser Ala Asp Ser Thr Arg Leu Leu His 
            180                 185                 190         


Trp Gly Ser His Pro Thr Ala Phe Val Val Ser Tyr Ala Ala Ala Leu 
        195                 200                 205             


Pro Ala Ala Ala Leu Trp His Lys Leu Gly Ser Leu Trp Val Pro Gly 
    210                 215                 220                 


Gly Gln Gly Gly Ser Gly Asn Pro Val Arg Arg Leu Leu Gly Cys Leu 
225                 230                 235                 240 


Gly Ser Glu Thr Arg Arg Leu Ser Leu Phe Leu Val Leu Val Val Leu 
                245                 250                 255     


Ser Ser Leu Gly Glu Met Ala Ile Pro Phe Phe Thr Gly Arg Leu Thr 
            260                 265                 270         


Asp Trp Ile Leu Gln Asp Gly Ser Ala Asp Thr Phe Thr Arg Asn Leu 
        275                 280                 285             


Thr Leu Met Ser Ile Leu Thr Ile Ala Ser Ala Val Leu Glu Phe Val 
    290                 295                 300                 


Gly Asp Gly Ile Tyr Asn Asn Thr Met Gly His Val His Ser His Leu 
305                 310                 315                 320 


Gln Gly Glu Val Phe Gly Ala Val Leu Arg Gln Glu Thr Glu Phe Phe 
                325                 330                 335     


Gln Gln Asn Gln Thr Gly Asn Ile Met Ser Arg Val Thr Glu Asp Thr 
            340                 345                 350         


Ser Thr Leu Ser Asp Ser Leu Ser Glu Asn Leu Ser Leu Phe Leu Trp 
        355                 360                 365             


Tyr Leu Val Arg Gly Leu Cys Leu Leu Gly Ile Met Leu Trp Gly Ser 
    370                 375                 380                 


Val Ser Leu Thr Met Val Thr Leu Ile Thr Leu Pro Leu Leu Phe Leu 
385                 390                 395                 400 


Leu Pro Lys Lys Val Gly Lys Trp Tyr Gln Leu Leu Glu Val Gln Val 
                405                 410                 415     


Arg Glu Ser Leu Ala Lys Ser Ser Gln Val Ala Ile Glu Ala Leu Ser 
            420                 425                 430         


Ala Met Pro Thr Val Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln 
        435                 440                 445             


Lys Phe Arg Glu Lys Leu Gln Glu Ile Lys Thr Leu Asn Gln Lys Glu 
    450                 455                 460                 


Ala Val Ala Tyr Ala Val Asn Ser Trp Thr Thr Ser Ile Ser Gly Met 
465                 470                 475                 480 


Leu Leu Lys Val Gly Ile Leu Tyr Ile Gly Gly Gln Leu Val Thr Ser 
                485                 490                 495     


Gly Ala Val Ser Ser Gly Asn Leu Val Thr Phe Val Leu Tyr Gln Met 
            500                 505                 510         


Gln Phe Thr Gln Ala Val Glu Val Leu Leu Ser Ile Tyr Pro Arg Val 
        515                 520                 525             


Gln Lys Ala Val Gly Ser Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg 
    530                 535                 540                 


Thr Pro Arg Cys Pro Pro Ser Gly Leu Leu Thr Pro Leu His Leu Glu 
545                 550                 555                 560 


Gly Leu Val Gln Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg Pro 
                565                 570                 575     


Asp Val Leu Val Leu Gln Gly Leu Thr Phe Thr Leu Arg Pro Gly Glu 
            580                 585                 590         


Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala 
        595                 600                 605             


Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu Leu 
    610                 615                 620                 


Asp Gly Lys Pro Leu Pro Gln Tyr Glu His Arg Tyr Leu His Arg Gln 
625                 630                 635                 640 


Val Ala Ala Val Gly Gln Glu Pro Gln Val Phe Gly Arg Ser Leu Gln 
                645                 650                 655     


Glu Asn Ile Ala Tyr Gly Leu Thr Gln Lys Pro Thr Met Glu Glu Ile 
            660                 665                 670         


Thr Ala Ala Ala Val Lys Ser Gly Ala His Ser Phe Ile Ser Gly Leu 
        675                 680                 685             


Pro Gln Gly Tyr Asp Thr Glu Val Asp Glu Ala Gly Ser Gln Leu Ser 
    690                 695                 700                 


Gly Gly Gln Arg Gln Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys 
705                 710                 715                 720 


Pro Cys Val Leu Ile Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Asn 
                725                 730                 735     


Ser Gln Leu Gln Val Glu Gln Leu Leu Tyr Glu Ser Pro Glu Arg Tyr 
            740                 745                 750         


Ser Arg Ser Val Leu Leu Ile Thr Gln His Leu Ser Leu Val Glu Gln 
        755                 760                 765             


Ala Asp His Ile Leu Phe Leu Glu Gly Gly Ala Ile Arg Glu Gly Gly 
    770                 775                 780                 


Thr His Gln Gln Leu Met Glu Lys Lys Gly Cys Tyr Trp Ala Met Val 
785                 790                 795                 800 


Gln Ala Pro Ala Asp Ala Pro Glu 
                805             


<210>  17
<211>  2234
<212>  DNA
<213>  Homo sapiens

<400>  17
gctctggggc cgaagggcgg ggcatcctca tctctaacag gaggcttttc tacttcatga       60

tctccagcct tcctaataaa atcctgaaag ttctggtaga gcaaccacag ggtagtgagt      120

tccagggcag cctatttagg ttcgggattg agacgtcagt gtttcctttc tgctgatgcc      180

ctccaggata atggggagat ggccattcca ttctttacgg gccgcctcac tgactggatt      240

ctacaagatg gctcagccga taccttcact cgaaacttaa ctctcatgtc cattctcacc      300

atagccagtg cagtgctgga gttcgtgggt gacgggatct ataacaacac catgggccac      360

gtgcacagcc acttgcaggg agaggtgttt ggggctgtcc tgcgccagga gacggagttt      420

ttccaacaga accagacagg taacatcatg tctcgggtaa cagaggacac gtccaccctg      480

agtgattctc tgagtgagaa tctgagctta tttctgtggt acctggtgcg aggcctatgt      540

ctcttgggga tcatgctctg gggatcagtg tccctcacca tggtcaccct gatcaccctg      600

cctctgcttt tccttctgcc caagaaggtg ggaaaatggt accagttgct ggaagtgcag      660

gtgcgggaat ctctggcaaa gtccagccag gtggccattg aggctctgtc ggccatgcct      720

acagttcgaa gctttgccaa cgaggagggc gaagcccaga agtttaggga aaagctgcaa      780

gaaataaaga cactcaacca gaaggaggct gtggcctatg cagtcaactc ctggaccact      840

agtatttcag gtatgctgct gaaagtggga atcctctaca ttggtgggca gctggtgacc      900

agtggggctg taagcagtgg gaaccttgtc acatttgttc tctaccagat gcagttcacc      960

caggctgtgg aggtactgct ctccatctac cccagagtac agaaggctgt gggctcctca     1020

gagaaaatat ttgagtacct ggaccgcacc cctcgctgcc cacccagtgg tctgttgact     1080

cccttacact tggagggcct tgtccagttc caagatgtct cctttgccta cccaaaccgc     1140

ccagatgtct tagtgctaca ggggctgaca ttcaccctac gccctggcga ggtgacggcg     1200

ctggtgggac ccaatgggtc tgggaagagc acagtggctg ccctgctgca gaatctgtac     1260

cagcccaccg ggggacagct gctgttggat gggaagcccc ttccccaata tgagcaccgc     1320

tacctgcaca ggcaggtggc tgcagtggga caagagccac aggtatttgg aagaagtctt     1380

caagaaaata ttgcctatgg cctgacccag aagccaacta tggaggaaat cacagctgct     1440

gcagtaaagt ctggggccca tagtttcatc tctggactcc ctcagggcta tgacacagag     1500

gtagacgagg ctgggagcca gctgtcaggg ggtcagcgac aggcagtggc gttggcccga     1560

gcattgatcc ggaaaccgtg tgtacttatc ctggatgatg ccaccagtgc cctggatgca     1620

aacagccagt tacaggtgga gcagctcctg tacgaaagcc ctgagcggta ctcccgctca     1680

gtgcttctca tcacccagca cctcagcctg gtggagcagg ctgaccacat cctctttctg     1740

gaaggaggcg ctatccggga ggggggaacc caccagcagc tcatggagaa aaaggggtgc     1800

tactgggcca tggtgcaggc tcctgcagat gctccagaat gaaagccttc tcagacctgc     1860

gcactccatc tccctccctt ttcttctctc tgtggtggag aaccacagct gcagagtagg     1920

cagctgcctc caggatgagt tacttgaaat ttgccttgag tgtgttacct cctttccaag     1980

ctcctcgtga taatgcagac ttcctggagt acaaacacag gatttgtaat tccttactgt     2040

aacggagttt agagccaggg ctgatgcttt ggtgtggcca gcactctgaa actgagaaat     2100

gttcagaatg tacggaaaga tgatcagcta ttttcaacat aactgaaggc atatgctggc     2160

ccataaacac cctgtaggtt cttgatattt ataataaaat tggtgttttg taaaaaaaaa     2220

aaaaaaaaaa aaaa                                                       2234


<210>  18
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ile Pro Phe Phe Thr Gly Arg Leu Thr Asp Trp Ile Leu Gln 
1               5                   10                  15      


Asp Gly Ser Ala Asp Thr Phe Thr Arg Asn Leu Thr Leu Met Ser Ile 
            20                  25                  30          


Leu Thr Ile Ala Ser Ala Val Leu Glu Phe Val Gly Asp Gly Ile Tyr 
        35                  40                  45              


Asn Asn Thr Met Gly His Val His Ser His Leu Gln Gly Glu Val Phe 
    50                  55                  60                  


Gly Ala Val Leu Arg Gln Glu Thr Glu Phe Phe Gln Gln Asn Gln Thr 
65                  70                  75                  80  


Gly Asn Ile Met Ser Arg Val Thr Glu Asp Thr Ser Thr Leu Ser Asp 
                85                  90                  95      


Ser Leu Ser Glu Asn Leu Ser Leu Phe Leu Trp Tyr Leu Val Arg Gly 
            100                 105                 110         


Leu Cys Leu Leu Gly Ile Met Leu Trp Gly Ser Val Ser Leu Thr Met 
        115                 120                 125             


Val Thr Leu Ile Thr Leu Pro Leu Leu Phe Leu Leu Pro Lys Lys Val 
    130                 135                 140                 


Gly Lys Trp Tyr Gln Leu Leu Glu Val Gln Val Arg Glu Ser Leu Ala 
145                 150                 155                 160 


Lys Ser Ser Gln Val Ala Ile Glu Ala Leu Ser Ala Met Pro Thr Val 
                165                 170                 175     


Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln Lys Phe Arg Glu Lys 
            180                 185                 190         


Leu Gln Glu Ile Lys Thr Leu Asn Gln Lys Glu Ala Val Ala Tyr Ala 
        195                 200                 205             


Val Asn Ser Trp Thr Thr Ser Ile Ser Gly Met Leu Leu Lys Val Gly 
    210                 215                 220                 


Ile Leu Tyr Ile Gly Gly Gln Leu Val Thr Ser Gly Ala Val Ser Ser 
225                 230                 235                 240 


Gly Asn Leu Val Thr Phe Val Leu Tyr Gln Met Gln Phe Thr Gln Ala 
                245                 250                 255     


Val Glu Val Leu Leu Ser Ile Tyr Pro Arg Val Gln Lys Ala Val Gly 
            260                 265                 270         


Ser Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg Thr Pro Arg Cys Pro 
        275                 280                 285             


Pro Ser Gly Leu Leu Thr Pro Leu His Leu Glu Gly Leu Val Gln Phe 
    290                 295                 300                 


Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg Pro Asp Val Leu Val Leu 
305                 310                 315                 320 


Gln Gly Leu Thr Phe Thr Leu Arg Pro Gly Glu Val Thr Ala Leu Val 
                325                 330                 335     


Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala Ala Leu Leu Gln Asn 
            340                 345                 350         


Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu Leu Asp Gly Lys Pro Leu 
        355                 360                 365             


Pro Gln Tyr Glu His Arg Tyr Leu His Arg Gln Val Ala Ala Val Gly 
    370                 375                 380                 


Gln Glu Pro Gln Val Phe Gly Arg Ser Leu Gln Glu Asn Ile Ala Tyr 
385                 390                 395                 400 


Gly Leu Thr Gln Lys Pro Thr Met Glu Glu Ile Thr Ala Ala Ala Val 
                405                 410                 415     


Lys Ser Gly Ala His Ser Phe Ile Ser Gly Leu Pro Gln Gly Tyr Asp 
            420                 425                 430         


Thr Glu Val Asp Glu Ala Gly Ser Gln Leu Ser Gly Gly Gln Arg Gln 
        435                 440                 445             


Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys Pro Cys Val Leu Ile 
    450                 455                 460                 


Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Asn Ser Gln Leu Gln Val 
465                 470                 475                 480 


Glu Gln Leu Leu Tyr Glu Ser Pro Glu Arg Tyr Ser Arg Ser Val Leu 
                485                 490                 495     


Leu Ile Thr Gln His Leu Ser Leu Val Glu Gln Ala Asp His Ile Leu 
            500                 505                 510         


Phe Leu Glu Gly Gly Ala Ile Arg Glu Gly Gly Thr His Gln Gln Leu 
        515                 520                 525             


Met Glu Lys Lys Gly Cys Tyr Trp Ala Met Val Gln Ala Pro Ala Asp 
    530                 535                 540                 


Ala Pro Glu 
545         


<210>  19
<211>  2950
<212>  DNA
<213>  Mus musculus

<400>  19
gaggagaatg agattcatgg agaagaacac gacaggccag ggctgctagg cagaactcca       60

actacagctt cagcggcagc ttccagaaca gcctgagcaa gccagtctca gaaggaggcg      120

tgtctagtga ttcgaggtcg gctttcggtt tcttcttcct ctaaacgcca gcacttctag      180

tcagctccac cagctcgagc gggttcccgg gactttacgc gcacgccctc ggacccgccc      240

ttcttccttc cccacggaga ctcctgtgca gcgcggacgt cgagagtccc aggctaggac      300

cagactctgg acagctcacg ctcgatggct gcgcacgtct ggctggcggc cgccctgctc      360

cttctggtgg actggctgct gctgcggccc atgctcccgg gaatcttctc cctgttggtt      420

cccgaggtgc cgctgctccg ggtctgggtg gtgggcctga gtcgctgggc catcctagga      480

ctaggggtcc gcggggtcct cggggtcacc gcaggagccc atggctggct ggctgctttg      540

cagccgctgg tggccgcact gagtttggcc ctgcctggac ttgccttgtt ccgagagctg      600

gccgcctggg gaacactccg ggagggtgac agcgctggat tactgtactg gaacagtcgt      660

ccagatgcct tcgctatcag ttatgtggca gcattgcccg cagccgccct gtggcacaag      720

ttggggagcc tctgggcgcc cagcggcaac agggacgctg gagacatgct gtgtcggatg      780

ctgggcttcc tgggccctaa gaagagacgt ctctacctgg ttctggttct cttgattctc      840

tcttgccttg gggaaatggc cattcccttc ttcacgggcc gcatcactga ctggattctt      900

caggataaga cagttcctag cttcacccgc aacatatggc tcatgtccat tctcaccata      960

gccagcacag cgctggagtt tgcaagtgat ggaatctaca acatcaccat gggacacatg     1020

cacggccgtg tgcacagaga ggtgtttcgg gccgtccttc gccaggagac agggtttttc     1080

ctgaagaacc cagcaggttc catcacatct cgggtgactg aggacacagc caacgtgtgc     1140

gagtccatta gtggcacgct gagcctgctg ctgtggtacc tggggcgagc cctgtgtctc     1200

ttggtgttca tgttttgggg gtcaccgtac ctcactctgg tcaccctgat caacctgccc     1260

ctgctttttc ttttgcctaa gaagctggga aaagtgcatc agtcactggc agtgaaggtg     1320

caggagtctc tagcaaagtc cacgcaggtg gcccttgagg ccttatcggc gatgcctact     1380

gtgcggagct ttgccaacga ggagggtgag gcccagaagt tcaggcagaa gttggaagaa     1440

atgaagactc taaacaagaa ggaggccttg gcttacgtgg ctgaagtctg gaccacgagt     1500

gtctcgggaa tgctgctgaa ggtgggaatt ctgtacctgg gcgggcagct ggtgatcaga     1560

ggggctgtca gcagcggcaa ccttgtctca ttcgttctct accagcttca gttcacccag     1620

gctgttcagg tcctgctctc cctctacccc tccatgcaga aggctgtggg ctcctcagag     1680

aaaatattcg aatacttgga ccggactcct tgctctccac tcagtggctc gttggcaccc     1740

tcaaacatga aaggccttgt ggagttccaa gatgtctctt ttgcctaccc aaaccagccc     1800

aaagtccagg tgcttcaggg gctgacgttc accctgcatc ctggaacggt gacagcgttg     1860

gtgggaccca atggatcagg gaagagcacc gtggctgccc tgctgcagaa cctgtaccag     1920

cccaccgggg gccagctgct gctggatggc cagtgcctgg tccagtatga tcaccattac     1980

ctgcacactc aggtggccgc agtgggacaa gagccgctgc tatttggaag aagctttcga     2040

gaaaatattg cgtatggcct gaaccggact ccaaccatgg aggaaatcac agctgtggcc     2100

gtggagtctg gagcccacga tttcatctct gggttccctc agggctatga cacagaggta     2160

ggtgagactg ggaaccagct gtcaggaggt cagcgacagg cagtggcctt ggcccgagcc     2220

ttgatccgga agccactcct gcttatcttg gatgatgcca ccagtgccct ggatgctggc     2280

aaccagctac gggtccagcg gctcctgtat gagagcccca agcgggcttc tcggacggtt     2340

cttcttatca cccagcagct cagcctggca gagcaggccc accacatcct ctttctcaga     2400

gaaggctctg tcggcgagca gggcacccac ctgcagctca tgaagagagg agggtgctac     2460

cgggccatgg tagaggctct tgcggctcct gcagactgac aaggcctctg gactgcacac     2520

tgcgtgctgt ccccctcctg tcctctactc tgtgtgacag agaacctggg agcaaagata     2580

ttaccacacc cacggagaca gttgaggagc ggaggtgctt gttacatgag aaaatgtaaa     2640

ctctaggaga tacccggaat ttaccacgaa tgtgtttccc cgacccgctc cctattagac     2700

ggggtttcag gtacctcaca ccaacactga gctgctaaat ctccggtctc caccctcccg     2760

gtgctgagct tgtatcacag catgcacaca caaacctggt ttatgtggcg ttgtgataga     2820

atgagaagaa acgcccaaag tgtacagaga gaaaggacaa gcagcttgca attaaccaaa     2880

ggcataggct ggcatttggg tgttctatgg gtgtttgata tttgtaataa aactggtgtt     2940

ttgtactgtg                                                            2950


<210>  20
<211>  724
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ala Ala His Val Trp Leu Ala Ala Ala Leu Leu Leu Leu Val Asp 
1               5                   10                  15      


Trp Leu Leu Leu Arg Pro Met Leu Pro Gly Ile Phe Ser Leu Leu Val 
            20                  25                  30          


Pro Glu Val Pro Leu Leu Arg Val Trp Val Val Gly Leu Ser Arg Trp 
        35                  40                  45              


Ala Ile Leu Gly Leu Gly Val Arg Gly Val Leu Gly Val Thr Ala Gly 
    50                  55                  60                  


Ala His Gly Trp Leu Ala Ala Leu Gln Pro Leu Val Ala Ala Leu Ser 
65                  70                  75                  80  


Leu Ala Leu Pro Gly Leu Ala Leu Phe Arg Glu Leu Ala Ala Trp Gly 
                85                  90                  95      


Thr Leu Arg Glu Gly Asp Ser Ala Gly Leu Leu Tyr Trp Asn Ser Arg 
            100                 105                 110         


Pro Asp Ala Phe Ala Ile Ser Tyr Val Ala Ala Leu Pro Ala Ala Ala 
        115                 120                 125             


Leu Trp His Lys Leu Gly Ser Leu Trp Ala Pro Ser Gly Asn Arg Asp 
    130                 135                 140                 


Ala Gly Asp Met Leu Cys Arg Met Leu Gly Phe Leu Gly Pro Lys Lys 
145                 150                 155                 160 


Arg Arg Leu Tyr Leu Val Leu Val Leu Leu Ile Leu Ser Cys Leu Gly 
                165                 170                 175     


Glu Met Ala Ile Pro Phe Phe Thr Gly Arg Ile Thr Asp Trp Ile Leu 
            180                 185                 190         


Gln Asp Lys Thr Val Pro Ser Phe Thr Arg Asn Ile Trp Leu Met Ser 
        195                 200                 205             


Ile Leu Thr Ile Ala Ser Thr Ala Leu Glu Phe Ala Ser Asp Gly Ile 
    210                 215                 220                 


Tyr Asn Ile Thr Met Gly His Met His Gly Arg Val His Arg Glu Val 
225                 230                 235                 240 


Phe Arg Ala Val Leu Arg Gln Glu Thr Gly Phe Phe Leu Lys Asn Pro 
                245                 250                 255     


Ala Gly Ser Ile Thr Ser Arg Val Thr Glu Asp Thr Ala Asn Val Cys 
            260                 265                 270         


Glu Ser Ile Ser Gly Thr Leu Ser Leu Leu Leu Trp Tyr Leu Gly Arg 
        275                 280                 285             


Ala Leu Cys Leu Leu Val Phe Met Phe Trp Gly Ser Pro Tyr Leu Thr 
    290                 295                 300                 


Leu Val Thr Leu Ile Asn Leu Pro Leu Leu Phe Leu Leu Pro Lys Lys 
305                 310                 315                 320 


Leu Gly Lys Val His Gln Ser Leu Ala Val Lys Val Gln Glu Ser Leu 
                325                 330                 335     


Ala Lys Ser Thr Gln Val Ala Leu Glu Ala Leu Ser Ala Met Pro Thr 
            340                 345                 350         


Val Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln Lys Phe Arg Gln 
        355                 360                 365             


Lys Leu Glu Glu Met Lys Thr Leu Asn Lys Lys Glu Ala Leu Ala Tyr 
    370                 375                 380                 


Val Ala Glu Val Trp Thr Thr Ser Val Ser Gly Met Leu Leu Lys Val 
385                 390                 395                 400 


Gly Ile Leu Tyr Leu Gly Gly Gln Leu Val Ile Arg Gly Ala Val Ser 
                405                 410                 415     


Ser Gly Asn Leu Val Ser Phe Val Leu Tyr Gln Leu Gln Phe Thr Gln 
            420                 425                 430         


Ala Val Gln Val Leu Leu Ser Leu Tyr Pro Ser Met Gln Lys Ala Val 
        435                 440                 445             


Gly Ser Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg Thr Pro Cys Ser 
    450                 455                 460                 


Pro Leu Ser Gly Ser Leu Ala Pro Ser Asn Met Lys Gly Leu Val Glu 
465                 470                 475                 480 


Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Gln Pro Lys Val Gln Val 
                485                 490                 495     


Leu Gln Gly Leu Thr Phe Thr Leu His Pro Gly Thr Val Thr Ala Leu 
            500                 505                 510         


Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala Ala Leu Leu Gln 
        515                 520                 525             


Asn Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu Leu Asp Gly Gln Cys 
    530                 535                 540                 


Leu Val Gln Tyr Asp His His Tyr Leu His Thr Gln Val Ala Ala Val 
545                 550                 555                 560 


Gly Gln Glu Pro Leu Leu Phe Gly Arg Ser Phe Arg Glu Asn Ile Ala 
                565                 570                 575     


Tyr Gly Leu Asn Arg Thr Pro Thr Met Glu Glu Ile Thr Ala Val Ala 
            580                 585                 590         


Val Glu Ser Gly Ala His Asp Phe Ile Ser Gly Phe Pro Gln Gly Tyr 
        595                 600                 605             


Asp Thr Glu Val Gly Glu Thr Gly Asn Gln Leu Ser Gly Gly Gln Arg 
    610                 615                 620                 


Gln Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys Pro Leu Leu Leu 
625                 630                 635                 640 


Ile Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Gly Asn Gln Leu Arg 
                645                 650                 655     


Val Gln Arg Leu Leu Tyr Glu Ser Pro Lys Arg Ala Ser Arg Thr Val 
            660                 665                 670         


Leu Leu Ile Thr Gln Gln Leu Ser Leu Ala Glu Gln Ala His His Ile 
        675                 680                 685             


Leu Phe Leu Arg Glu Gly Ser Val Gly Glu Gln Gly Thr His Leu Gln 
    690                 695                 700                 


Leu Met Lys Arg Gly Gly Cys Tyr Arg Ala Met Val Glu Ala Leu Ala 
705                 710                 715                 720 


Ala Pro Ala Asp 
                


<210>  21
<211>  2866
<212>  DNA
<213>  Mus musculus

<400>  21
gaggagaatg agattcatgg agaagaacac gacaggccag ggctgctagg cagaactcca       60

actacagctt cagcggcagc ttccagaaca gcctgagcaa gccagtctca gaaggaggcg      120

tgtctagtga ttcgaggtcg gctttcggtt tcttcttcct ctaaacgcca gcacttctag      180

tcagctccac cagctcgagc gggttcccgg gactttacgc gcacgccctc ggacccgccc      240

ttcttccttc cccacggaga ctcctgtgca gcgcggacgt cgagagtccc aggctaggac      300

cagactctgg acagctcacg ctcgatggct gcgcacgtct ggctggcggc cgccctgctc      360

cttctggtgg actggctgct gctgcggccc atgctcccgg gaatcttctc cctgttggtt      420

cccgaggtgc cgctgctccg ggtctgggtg gtgggcctga gtcgctgggc catcctagga      480

ctaggggtcc gcggggtcct cggggtcacc gcaggagccc atggctggct ggctgctttg      540

cagccgctgg tggccgcact gagtttggcc ctgcctggac ttgccttgtt ccgagagctg      600

gccgcctggg gaacactccg ggagggtgac agcgctggat tactgtactg gaacagtcgt      660

ccagatgcct tcgctatcag ttatgtggca gcattgcccg cagccgccct gtggcacaag      720

ttggggagcc tctgggcgcc cagcggcaac agggacgctg gagacatgct gtgtcggatg      780

ctgggcttcc tgggccctaa gaagagacgt ctctacctgg ttctggttct cttgattctc      840

tcttgccttg gggaaatggc cattcccttc ttcacgggcc gcatcactga ctggattctt      900

caggataaga cagttcctag cttcacccgc aacatatggc tcatgtccat tctcaccata      960

gccagcacag cgctggagtt tgcaagtgat ggaatctaca acatcaccat gggacacatg     1020

cacggccgtg tgcacagaga ggtgtttcgg gccgtccttc gccaggagac agggtttttc     1080

ctgaagaacc cagcaggttc catcacatct cgggtgactg aggacacagc caacgtgtgc     1140

gagtccatta gtggcacgct gagcctgctg ctgtggtacc tggggcgagc cctgtgtctc     1200

ttggtgttca tgttttgggg gtcaccgtac ctcactctgg tcaccctgat caacctgccc     1260

ctgctttttc ttttgcctaa gaagctggga aaagtgcatc agtcactggc agtgaaggtg     1320

caggagtctc tagcaaagtc cacgcaggtg gcccttgagg ccttatcggc gatgcctact     1380

gtgcggagct ttgccaacga ggagggtgag gcccagaagt tcaggcagaa gttggaagaa     1440

atgaagactc taaacaagaa ggaggccttg gcttacgtgg ctgaagtctg gaccacgagt     1500

gtctcgggaa tgctgctgaa gcttcagttc acccaggctg ttcaggtcct gctctccctc     1560

tacccctcca tgcagaaggc tgtgggctcc tcagagaaaa tattcgaata cttggaccgg     1620

actccttgct ctccactcag tggctcgttg gcaccctcaa acatgaaagg ccttgtggag     1680

ttccaagatg tctcttttgc ctacccaaac cagcccaaag tccaggtgct tcaggggctg     1740

acgttcaccc tgcatcctgg aacggtgaca gcgttggtgg gacccaatgg atcagggaag     1800

agcaccgtgg ctgccctgct gcagaacctg taccagccca ccgggggcca gctgctgctg     1860

gatggccagt gcctggtcca gtatgatcac cattacctgc acactcaggt ggccgcagtg     1920

ggacaagagc cgctgctatt tggaagaagc tttcgagaaa atattgcgta tggcctgaac     1980

cggactccaa ccatggagga aatcacagct gtggccgtgg agtctggagc ccacgatttc     2040

atctctgggt tccctcaggg ctatgacaca gaggtaggtg agactgggaa ccagctgtca     2100

ggaggtcagc gacaggcagt ggccttggcc cgagccttga tccggaagcc actcctgctt     2160

atcttggatg atgccaccag tgccctggat gctggcaacc agctacgggt ccagcggctc     2220

ctgtatgaga gccccaagcg ggcttctcgg acggttcttc ttatcaccca gcagctcagc     2280

ctggcagagc aggcccacca catcctcttt ctcagagaag gctctgtcgg cgagcagggc     2340

acccacctgc agctcatgaa gagaggaggg tgctaccggg ccatggtaga ggctcttgcg     2400

gctcctgcag actgacaagg cctctggact gcacactgcg tgctgtcccc ctcctgtcct     2460

ctactctgtg tgacagagaa cctgggagca aagatattac cacacccacg gagacagttg     2520

aggagcggag gtgcttgtta catgagaaaa tgtaaactct aggagatacc cggaatttac     2580

cacgaatgtg tttccccgac ccgctcccta ttagacgggg tttcaggtac ctcacaccaa     2640

cactgagctg ctaaatctcc ggtctccacc ctcccggtgc tgagcttgta tcacagcatg     2700

cacacacaaa cctggtttat gtggcgttgt gatagaatga gaagaaacgc ccaaagtgta     2760

cagagagaaa ggacaagcag cttgcaatta accaaaggca taggctggca tttgggtgtt     2820

ctatgggtgt ttgatatttg taataaaact ggtgttttgt actgtg                    2866


<210>  22
<211>  696
<212>  PRT
<213>  Mus musculus

<400>  22

Met Ala Ala His Val Trp Leu Ala Ala Ala Leu Leu Leu Leu Val Asp 
1               5                   10                  15      


Trp Leu Leu Leu Arg Pro Met Leu Pro Gly Ile Phe Ser Leu Leu Val 
            20                  25                  30          


Pro Glu Val Pro Leu Leu Arg Val Trp Val Val Gly Leu Ser Arg Trp 
        35                  40                  45              


Ala Ile Leu Gly Leu Gly Val Arg Gly Val Leu Gly Val Thr Ala Gly 
    50                  55                  60                  


Ala His Gly Trp Leu Ala Ala Leu Gln Pro Leu Val Ala Ala Leu Ser 
65                  70                  75                  80  


Leu Ala Leu Pro Gly Leu Ala Leu Phe Arg Glu Leu Ala Ala Trp Gly 
                85                  90                  95      


Thr Leu Arg Glu Gly Asp Ser Ala Gly Leu Leu Tyr Trp Asn Ser Arg 
            100                 105                 110         


Pro Asp Ala Phe Ala Ile Ser Tyr Val Ala Ala Leu Pro Ala Ala Ala 
        115                 120                 125             


Leu Trp His Lys Leu Gly Ser Leu Trp Ala Pro Ser Gly Asn Arg Asp 
    130                 135                 140                 


Ala Gly Asp Met Leu Cys Arg Met Leu Gly Phe Leu Gly Pro Lys Lys 
145                 150                 155                 160 


Arg Arg Leu Tyr Leu Val Leu Val Leu Leu Ile Leu Ser Cys Leu Gly 
                165                 170                 175     


Glu Met Ala Ile Pro Phe Phe Thr Gly Arg Ile Thr Asp Trp Ile Leu 
            180                 185                 190         


Gln Asp Lys Thr Val Pro Ser Phe Thr Arg Asn Ile Trp Leu Met Ser 
        195                 200                 205             


Ile Leu Thr Ile Ala Ser Thr Ala Leu Glu Phe Ala Ser Asp Gly Ile 
    210                 215                 220                 


Tyr Asn Ile Thr Met Gly His Met His Gly Arg Val His Arg Glu Val 
225                 230                 235                 240 


Phe Arg Ala Val Leu Arg Gln Glu Thr Gly Phe Phe Leu Lys Asn Pro 
                245                 250                 255     


Ala Gly Ser Ile Thr Ser Arg Val Thr Glu Asp Thr Ala Asn Val Cys 
            260                 265                 270         


Glu Ser Ile Ser Gly Thr Leu Ser Leu Leu Leu Trp Tyr Leu Gly Arg 
        275                 280                 285             


Ala Leu Cys Leu Leu Val Phe Met Phe Trp Gly Ser Pro Tyr Leu Thr 
    290                 295                 300                 


Leu Val Thr Leu Ile Asn Leu Pro Leu Leu Phe Leu Leu Pro Lys Lys 
305                 310                 315                 320 


Leu Gly Lys Val His Gln Ser Leu Ala Val Lys Val Gln Glu Ser Leu 
                325                 330                 335     


Ala Lys Ser Thr Gln Val Ala Leu Glu Ala Leu Ser Ala Met Pro Thr 
            340                 345                 350         


Val Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln Lys Phe Arg Gln 
        355                 360                 365             


Lys Leu Glu Glu Met Lys Thr Leu Asn Lys Lys Glu Ala Leu Ala Tyr 
    370                 375                 380                 


Val Ala Glu Val Trp Thr Thr Ser Val Ser Gly Met Leu Leu Lys Leu 
385                 390                 395                 400 


Gln Phe Thr Gln Ala Val Gln Val Leu Leu Ser Leu Tyr Pro Ser Met 
                405                 410                 415     


Gln Lys Ala Val Gly Ser Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg 
            420                 425                 430         


Thr Pro Cys Ser Pro Leu Ser Gly Ser Leu Ala Pro Ser Asn Met Lys 
        435                 440                 445             


Gly Leu Val Glu Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Gln Pro 
    450                 455                 460                 


Lys Val Gln Val Leu Gln Gly Leu Thr Phe Thr Leu His Pro Gly Thr 
465                 470                 475                 480 


Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala 
                485                 490                 495     


Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu Leu 
            500                 505                 510         


Asp Gly Gln Cys Leu Val Gln Tyr Asp His His Tyr Leu His Thr Gln 
        515                 520                 525             


Val Ala Ala Val Gly Gln Glu Pro Leu Leu Phe Gly Arg Ser Phe Arg 
    530                 535                 540                 


Glu Asn Ile Ala Tyr Gly Leu Asn Arg Thr Pro Thr Met Glu Glu Ile 
545                 550                 555                 560 


Thr Ala Val Ala Val Glu Ser Gly Ala His Asp Phe Ile Ser Gly Phe 
                565                 570                 575     


Pro Gln Gly Tyr Asp Thr Glu Val Gly Glu Thr Gly Asn Gln Leu Ser 
            580                 585                 590         


Gly Gly Gln Arg Gln Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys 
        595                 600                 605             


Pro Leu Leu Leu Ile Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Gly 
    610                 615                 620                 


Asn Gln Leu Arg Val Gln Arg Leu Leu Tyr Glu Ser Pro Lys Arg Ala 
625                 630                 635                 640 


Ser Arg Thr Val Leu Leu Ile Thr Gln Gln Leu Ser Leu Ala Glu Gln 
                645                 650                 655     


Ala His His Ile Leu Phe Leu Arg Glu Gly Ser Val Gly Glu Gln Gly 
            660                 665                 670         


Thr His Leu Gln Leu Met Lys Arg Gly Gly Cys Tyr Arg Ala Met Val 
        675                 680                 685             


Glu Ala Leu Ala Ala Pro Ala Asp 
    690                 695     


<210>  23
<211>  5679
<212>  DNA
<213>  Homo sapiens

<400>  23
gcccgccctg gccgagcgta gctggcggac cagagccggt agcgaggttg ggagagacgg       60

agcggacctc agcgctgaag cagaagtccc cggagctgcg gtctccccgc cgcggctgag      120

ccatgcggct ccctgacctg agaccctgga cctccctgct gctggtggac gcggctttac      180

tgtggctgct tcagggccct ctggggactt tgcttcctca agggctgcca ggactatggc      240

tggaggggac cctgcggctg ggagggctgt gggggctgct aaagctaaga gggctgctgg      300

gatttgtggg gacactgctg ctcccgctct gtctggccac ccccctgact gtctccctga      360

gagccctggt cgcgggggcc tcacgtgctc ccccagccag agtcgcttca gccccttgga      420

gctggctgct ggtggggtac ggggctgcgg ggctcagctg gtcactgtgg gctgttctga      480

gccctcctgg agcccaggag aaggagcagg accaggtgaa caacaaagtc ttgatgtgga      540

ggctgctgaa gctctccagg ccggacctgc ctctcctcgt tgccgccttc ttcttccttg      600

tccttgctgt tttgggtgag acattaatcc ctcactattc tggtcgtgtg attgacatcc      660

tgggaggtga ttttgacccc catgcctttg ccagtgccat cttcttcatg tgcctcttct      720

cctttggcag ctcactgtct gcaggctgcc gaggaggctg cttcacctac accatgtctc      780

gaatcaactt gcggatccgg gagcagcttt tctcctccct gctgcgccag gacctcggtt      840

tcttccagga gactaagaca ggggagctga actcacggct gagctcggat accaccctga      900

tgagtaactg gcttccttta aatgccaatg tgctcttgcg aagcctggtg aaagtggtgg      960

ggctgtatgg cttcatgctc agcatatcgc ctcgactcac cctcctttct ctgctgcaca     1020

tgcccttcac aatagcagcg gagaaggtgt acaacacccg ccatcaggaa gtgcttcggg     1080

agatccagga tgcagtggcc agggcggggc aggtggtgcg ggaagccgtt ggagggctgc     1140

agaccgttcg cagttttggg gccgaggagc atgaagtctg tcgctataaa gaggcccttg     1200

aacaatgtcg gcagctgtat tggcggagag acctggaacg cgccttgtac ctgctcgtaa     1260

ggagggtgct gcacttgggg gtgcagatgc tgatgctgag ctgtgggctg cagcagatgc     1320

aggatgggga gctcacccag ggcagcctgc tttcctttat gatctaccag gagagcgtgg     1380

ggagctatgt gcagaccctg gtatacatat atggggatat gctcagcaac gtgggagctg     1440

cagagaaggt tttctcctac atggaccgac agccaaatct gccttcacct ggcacgcttg     1500

cccccaccac tctgcagggg gttgtgaaat tccaagacgt ctcctttgca tatcccaatc     1560

gccctgacag gcctgtgctc aaggggctga cgtttaccct acgtcctggt gaggtgacgg     1620

cgctggtggg acccaatggg tctgggaaga gcacagtggc tgccctgctg cagaatctgt     1680

accagcccac agggggacag gtgctgctgg atgaaaagcc catctcacag tatgaacact     1740

gctacctgca cagccaggtg gtttcagttg ggcaggagcc tgtgctgttc tccggttctg     1800

tgaggaacaa cattgcttat gggctgcaga gctgcgaaga tgataaggtg atggcggctg     1860

cccaggctgc ccacgcagat gacttcatcc aggaaatgga gcatggaata tacacagatg     1920

taggggagaa gggaagccag ctggctgcgg gacagaaaca acgtctggcc attgcccggg     1980

cccttgtacg agacccgcgg gtcctcatcc tggatgaggc tactagtgcc ctagatgtgc     2040

agtgcgagca ggccctgcag gactggaatt cccgtgggga tcgcacagtg ctggtgattg     2100

ctcacaggct gcaggcagtt cagcgcgccc accagatcct ggtgctccag gagggcaagc     2160

tgcagaagct tgcccagctc caggagggac aggacctcta ttcccgcctg gttcagcagc     2220

ggctgatgga ctgaggcccc agggatactg ggccctcttc tcaggggcgt ctccaggacc     2280

cagagctgtt cctgctttga gtttccctag agctgtgcgg ccagatagct gttcctgagt     2340

tgcaggcacg atggagattt ggacactgtg tgcttttggt ggggtagaga ggtggggtgg     2400

ggtggggtgg gggctgtctg tgtccaggaa acttaattcc ctggtgacta gagctttgcc     2460

tggtgatgag gagtattttg tggcataata catatatttt aaaatatttt ccttcttaca     2520

tgaactgtat acattcatat agaaaattta gacaatataa aaaagtacaa agaagaaaag     2580

taaaagtacc cattgtttca cttcctggag ataaccatag ttgctatttt gctgcctgtc     2640

ccatcagtcg tttatctgtt gtttgagata gaaattaacc aaaaatgaca taaatattca     2700

tgagattgcc ttcctatatc cttccttgtt cctaccagtg tctgctattt tgaagaagct     2760

agggtctgga gggacagaga acagttccct gattaacagt attaatagcg acattggtaa     2820

cagctaccat ttatagagtt ttaatgggag taggagctat gctaagtgtt tttcatgtat     2880

tatcgttttt aatcattatc cccaacccta tgaggttggt tattatcccc attttacaga     2940

tgaggaaact gaagctcaaa gaggctcaat gactttccca aggtggtcgt agtggtggag     3000

ttggagtttg aacacaggcc tgaccctaga gtccacaccc tgacccaatc aattatattg     3060

catcttgggt ccataaaccc taatccataa tcccatcaag aaaagctctg ctgctcttag     3120

ctctaaataa ttcagaatct attctcttct ctccagtccc gttgttatag tcttcactca     3180

tagacttaag atgatcccat caccagagag gtttctctac cattagcttc cctcttccgg     3240

ccattcttca caaagtcatt tttctaaatt ctgtgtcaca tacgatgatg gcatttctgg     3300

aaattccttc aggtgctctc aagccctgct gcagagatcc ttttcagagc acacactgtt     3360

ccagcccatc tgtctcaccc tctcctgttg tatccagctc cacgacaaac ttctgccttc     3420

cccaacacct ttgtgccttt gcatatggtg ttttcttgcc cattttctgc tcgactcgcc     3480

cctgattttc aagttcaaga cttaactcag ggttcaggtc ttccaggagg ccttacttat     3540

gtcgtcagtc tggggaactc tccatgtgct tctatcactg tgcggttacc tctttcacag     3600

cccttttaaa gttctatctt ccctttccca ccttttttga ccttccacta gaccatgagc     3660

acctgggcgg aaagccatat atcttattaa gctttatatc tgctacctgg ccgagggcct     3720

aattcatagt ggagaataaa tagtcaattg aataaatgaa taaatatctc caccatcgta     3780

ctaatcttaa tcctccctgc ccactcccac cactgaaaat gcaacattgt acacatcact     3840

ggttgttggg agggacttac cttggaaagt tgctattcta ggaaagagaa accttcatat     3900

tcctggaaac agcaggtagt ttccagtgct ggcaatgaat tccccagaac tgctgttttg     3960

gattttttct tgcctggcag ctgttgggag cagggtgcag tgaggatggg gtgagagtgg     4020

gcagtttctt gtgcagattt gcctttcttt catcctgggg ctgacttgca gctccacacc     4080

catccatctc tcaaatttca cagagggtaa aataggcatt tggagagaaa gaactctggc     4140

ctgattcctt tctctcccac aaatgtcctt tattcataaa acaggaataa taattcctgt     4200

atctcccaac tacatggaag ctgcagccct cacagaagaa gatgatctga gaaattcttt     4260

gatttcctca gtacagttat acccatgcat cataatactt taagcctgga aggcatctta     4320

aaaataatgc aacagtcaaa cctaatttta cagagaaact gacatgaaat cacgcagcta     4380

atcatgataa agctgggtgg aaaacttatc ttgatgggca gtacaggaag atgcagtaga     4440

ccttaagatg tcctgaaagt ttcttatctc aggggaaact cccaggtagg ctttatgtca     4500

gggacacaga aaaatgctcc ctgaaagtca aaatattcgg gctagacaga caaattcctg     4560

taagtgtggt ttgtctggga accacagatg tcactaatcc tggtttgctc cagagttctt     4620

tttgttcact cctacccccc atcaccattt gattgatctc cttaccctgt aatttcccct     4680

tcttgtcgct tacctgcagt atctttccca cccaggcatg ccttattctt tctaaaggaa     4740

agtatgaatg gagaggggaa agcttgggaa actgatagat ttccttggat gccaaaacac     4800

ctccatagcc tgtctgcccg gccctatgtg gaaacagcat tgagtttcaa gtcctttatg     4860

cctccaccca gggatagcca cttgtaatcc acatggcaat tgtgaaacaa gcaggaaatg     4920

cgtaattgtc agaattttgt ggggaaagga ctagggaata aggaaaacaa agatcttcct     4980

tgtgttttag agctgtcagc tagaggagca cctgcttgag tctgatgcca tctaatggtc     5040

ccagaagaaa ctgggttttg aacctagagt tccatggact cttaggaatt agactactac     5100

tactactaag cattcactgg tgcttactat gtgctattgc tgtgccaagt atctgaaacc     5160

tgtcttctta ccttattttt caagataatt ctatgtggca ggtattacta tctcaattct     5220

aagagtgaga aaatggagtt ttagaaacat ttactaactt gcctgggtca catagctaag     5280

gaagaggtgg acttgcccag ctttgcataa aactcctcaa aagagttgcc tatactccct     5340

gactccactt atcttcctac tatcctcttt ttaaaatata ttatttattt atttaaataa     5400

gcaatatatg aatgtggttt gaaattcaaa agacacaaag aagtatacag aggaaagcct     5460

cactctcaat ccttctcaag gtttgctaat tcctcttgca taggcaatcc gttcttccag     5520

ctttgtgttt atctttccag agaagtttac tgtgtattaa gcaaatatgt atatctttat     5580

tcttgctcag tattttcgca aacagcagct gtctaagttc actgttctga actttatttt     5640

ttaaattaaa aatatatggc tatgtagtat tctatttta                            5679


<210>  24
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Leu Pro Asp Leu Arg Pro Trp Thr Ser Leu Leu Leu Val Asp 
1               5                   10                  15      


Ala Ala Leu Leu Trp Leu Leu Gln Gly Pro Leu Gly Thr Leu Leu Pro 
            20                  25                  30          


Gln Gly Leu Pro Gly Leu Trp Leu Glu Gly Thr Leu Arg Leu Gly Gly 
        35                  40                  45              


Leu Trp Gly Leu Leu Lys Leu Arg Gly Leu Leu Gly Phe Val Gly Thr 
    50                  55                  60                  


Leu Leu Leu Pro Leu Cys Leu Ala Thr Pro Leu Thr Val Ser Leu Arg 
65                  70                  75                  80  


Ala Leu Val Ala Gly Ala Ser Arg Ala Pro Pro Ala Arg Val Ala Ser 
                85                  90                  95      


Ala Pro Trp Ser Trp Leu Leu Val Gly Tyr Gly Ala Ala Gly Leu Ser 
            100                 105                 110         


Trp Ser Leu Trp Ala Val Leu Ser Pro Pro Gly Ala Gln Glu Lys Glu 
        115                 120                 125             


Gln Asp Gln Val Asn Asn Lys Val Leu Met Trp Arg Leu Leu Lys Leu 
    130                 135                 140                 


Ser Arg Pro Asp Leu Pro Leu Leu Val Ala Ala Phe Phe Phe Leu Val 
145                 150                 155                 160 


Leu Ala Val Leu Gly Glu Thr Leu Ile Pro His Tyr Ser Gly Arg Val 
                165                 170                 175     


Ile Asp Ile Leu Gly Gly Asp Phe Asp Pro His Ala Phe Ala Ser Ala 
            180                 185                 190         


Ile Phe Phe Met Cys Leu Phe Ser Phe Gly Ser Ser Leu Ser Ala Gly 
        195                 200                 205             


Cys Arg Gly Gly Cys Phe Thr Tyr Thr Met Ser Arg Ile Asn Leu Arg 
    210                 215                 220                 


Ile Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Gly Phe 
225                 230                 235                 240 


Phe Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp 
                245                 250                 255     


Thr Thr Leu Met Ser Asn Trp Leu Pro Leu Asn Ala Asn Val Leu Leu 
            260                 265                 270         


Arg Ser Leu Val Lys Val Val Gly Leu Tyr Gly Phe Met Leu Ser Ile 
        275                 280                 285             


Ser Pro Arg Leu Thr Leu Leu Ser Leu Leu His Met Pro Phe Thr Ile 
    290                 295                 300                 


Ala Ala Glu Lys Val Tyr Asn Thr Arg His Gln Glu Val Leu Arg Glu 
305                 310                 315                 320 


Ile Gln Asp Ala Val Ala Arg Ala Gly Gln Val Val Arg Glu Ala Val 
                325                 330                 335     


Gly Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu His Glu Val 
            340                 345                 350         


Cys Arg Tyr Lys Glu Ala Leu Glu Gln Cys Arg Gln Leu Tyr Trp Arg 
        355                 360                 365             


Arg Asp Leu Glu Arg Ala Leu Tyr Leu Leu Val Arg Arg Val Leu His 
    370                 375                 380                 


Leu Gly Val Gln Met Leu Met Leu Ser Cys Gly Leu Gln Gln Met Gln 
385                 390                 395                 400 


Asp Gly Glu Leu Thr Gln Gly Ser Leu Leu Ser Phe Met Ile Tyr Gln 
                405                 410                 415     


Glu Ser Val Gly Ser Tyr Val Gln Thr Leu Val Tyr Ile Tyr Gly Asp 
            420                 425                 430         


Met Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Met Asp 
        435                 440                 445             


Arg Gln Pro Asn Leu Pro Ser Pro Gly Thr Leu Ala Pro Thr Thr Leu 
    450                 455                 460                 


Gln Gly Val Val Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg 
465                 470                 475                 480 


Pro Asp Arg Pro Val Leu Lys Gly Leu Thr Phe Thr Leu Arg Pro Gly 
                485                 490                 495     


Glu Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val 
            500                 505                 510         


Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Val Leu 
        515                 520                 525             


Leu Asp Glu Lys Pro Ile Ser Gln Tyr Glu His Cys Tyr Leu His Ser 
    530                 535                 540                 


Gln Val Val Ser Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val 
545                 550                 555                 560 


Arg Asn Asn Ile Ala Tyr Gly Leu Gln Ser Cys Glu Asp Asp Lys Val 
                565                 570                 575     


Met Ala Ala Ala Gln Ala Ala His Ala Asp Asp Phe Ile Gln Glu Met 
            580                 585                 590         


Glu His Gly Ile Tyr Thr Asp Val Gly Glu Lys Gly Ser Gln Leu Ala 
        595                 600                 605             


Ala Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asp 
    610                 615                 620                 


Pro Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Val Gln 
625                 630                 635                 640 


Cys Glu Gln Ala Leu Gln Asp Trp Asn Ser Arg Gly Asp Arg Thr Val 
                645                 650                 655     


Leu Val Ile Ala His Arg Leu Gln Ala Val Gln Arg Ala His Gln Ile 
            660                 665                 670         


Leu Val Leu Gln Glu Gly Lys Leu Gln Lys Leu Ala Gln Leu Gln Glu 
        675                 680                 685             


Gly Gln Asp Leu Tyr Ser Arg Leu Val Gln Gln Arg Leu Met Asp 
    690                 695                 700             


<210>  25
<211>  5732
<212>  DNA
<213>  Homo sapiens

<400>  25
agaatgaagg ccttggctgg ggaagcgaaa gcgaaagctg cccgagccct gacgcccgcc       60

ctggccgagc gtagctggcg gaccagagcc ggtagcgagg ttgggagaga cggagcggac      120

ctcagcgctg aagcagaagt ccccggagct gcggtctccc cgccgcggct gagccatgcg      180

gctccctgac ctgagaccct ggacctccct gctgctggtg gacgcggctt tactgtggct      240

gcttcagggc cctctgggga ctttgcttcc tcaagggctg ccaggactat ggctggaggg      300

gaccctgcgg ctgggagggc tgtgggggct gctaaagcta agagggctgc tgggatttgt      360

ggggacactg ctgctcccgc tctgtctggc cacccccctg actgtctccc tgagagccct      420

ggtcgcgggg gcctcacgtg ctcccccagc cagagtcgct tcagcccctt ggagctggct      480

gctggtgggg tacggggctg cggggctcag ctggtcactg tgggctgttc tgagccctcc      540

tggagcccag gagaaggagc aggaccaggt gaacaacaaa gtcttgatgt ggaggctgct      600

gaagctctcc aggccggacc tgcctctcct cgttgccgcc ttcttcttcc ttgtccttgc      660

tgttttgggt gagacattaa tccctcacta ttctggtcgt gtgattgaca tcctgggagg      720

tgattttgac ccccatgcct ttgccagtgc catcttcttc atgtgcctct tctcctttgg      780

cagctcactg tctgcaggct gccgaggagg ctgcttcacc tacaccatgt ctcgaatcaa      840

cttgcggatc cgggagcagc ttttctcctc cctgctgcgc caggacctcg gtttcttcca      900

ggagactaag acaggggagc tgaactcacg gctgagctcg gataccaccc tgatgagtaa      960

ctggcttcct ttaaatgcca atgtgctctt gcgaagcctg gtgaaagtgg tggggctgta     1020

tggcttcatg ctcagcatat cgcctcgact caccctcctt tctctgctgc acatgccctt     1080

cacaatagca gcggagaagg tgtacaacac ccgccatcag gaagtgcttc gggagatcca     1140

ggatgcagtg gccagggcgg ggcaggtggt gcgggaagcc gttggagggc tgcagaccgt     1200

tcgcagtttt ggggccgagg agcatgaagt ctgtcgctat aaagaggccc ttgaacaatg     1260

tcggcagctg tattggcgga gagacctgga acgcgccttg tacctgctcg taaggagggt     1320

gctgcacttg ggggtgcaga tgctgatgct gagctgtggg ctgcagcaga tgcaggatgg     1380

ggagctcacc cagggcagcc tgctttcctt tatgatctac caggagagcg tggggagcta     1440

tgtgcagacc ctggtataca tatatgggga tatgctcagc aacgtgggag ctgcagagaa     1500

ggttttctcc tacatggacc gacagccaaa tctgccttca cctggcacgc ttgcccccac     1560

cactctgcag ggggttgtga aattccaaga cgtctccttt gcatatccca atcgccctga     1620

caggcctgtg ctcaaggggc tgacgtttac cctacgtcct ggtgaggtga cggcgctggt     1680

gggacccaat gggtctggga agagcacagt ggctgccctg ctgcagaatc tgtaccagcc     1740

cacaggggga caggtgctgc tggatgaaaa gcccatctca cagtatgaac actgctacct     1800

gcacagccag gtggtttcag ttgggcagga gcctgtgctg ttctccggtt ctgtgaggaa     1860

caacattgct tatgggctgc agagctgcga agatgataag gtgatggcgg ctgcccaggc     1920

tgcccacgca gatgacttca tccaggaaat ggagcatgga atatacacag atgtagggga     1980

gaagggaagc cagctggctg cgggacagaa acaacgtctg gccattgccc gggcccttgt     2040

acgagacccg cgggtcctca tcctggatga ggctactagt gccctagatg tgcagtgcga     2100

gcaggccctg caggactgga attcccgtgg ggatcgcaca gtgctggtga ttgctcacag     2160

gctgcagaca gttcagcgcg cccaccagat cctggtgctc caggagggca agctgcagaa     2220

gcttgcccag ctctaggagg gacaggacct ctattcccgc ctggtgcagc agcggctgat     2280

ggactgaggc cccagggata ctgggccctc ttctcagggg cgtctccagg acccagagct     2340

gttcctgctt tgagtttccc tagagctgtg cggccagata gctgttcctg agttgcaggc     2400

acgatggaga tttggacact gtgtgctttt ggtggggtag agaggtgggg tggggtgggg     2460

tgggggctgt ctgtgtccag gaaacttaat tccctggtga ctagagcttt gcctggtgat     2520

gaggagtatt ttgtggcata atacatatat tttaaaatat tttccttctt acatgaactg     2580

tatacattca tatagaaaat ttagacaata taaaaaagta caaagaagaa aagtaaaagt     2640

acccattgtt tcacttcctg gagataacca tagttgctat tttgctgcct gtcccatcag     2700

tcgtttatct gttgtttgag atagaaatta accaaaaatg acataaatat tcatgagatt     2760

gccttcctat atccttcctt gttcctacca gtgtctgcta ttttgaagaa gctagggtct     2820

ggagggacag agaacagttc cctgattaac agtattaata gcgacattgg taacagctac     2880

catttataga gttttaatgg gagtaggagc tatgctaagt gtttttcatg tattatcgtt     2940

tttaatcatt atccccaacc ctatgaggtt ggttattatc cccattttac agatgaggaa     3000

actgaagctc aaagaggctc aatgactttc ccaaggtggt cgtagtggtg gagttggagt     3060

ttgaacacag gcctgaccct agagtccaca ccctgaccca atcaattata ttgcatcttg     3120

ggtccataaa ccctaatcca taatcccatc aagaaaagct ctgctgctct tagctctaaa     3180

taattcagaa tctattctct tctctccagt cccgttgtta tagtcttcac tcatagactt     3240

aagatgatcc catcaccaga gaggtttctc taccattagc ttccctcttc cggccattct     3300

tcacaaagtc atttttctaa attctgtgtc acatacgatg atggcatttc tggaaattcc     3360

ttcaggtgct ctcaagccct gctgcagaga tccttttcag agcacacact gttccagccc     3420

atctgtctca ccctctcctg ttgtatccag ctccacgaca aacttctgcc ttccccaaca     3480

cctttgtgcc tttgcatatg gtgttttctt gcccattttc tgctcgactc gcccctgatt     3540

ttcaagttca agacttaact cagggttcag gtcttccagg aggccttact tatgtcgtca     3600

gtctggggaa ctctccatgt gcttctatca ctgtgcggtt acctctttca cagccctttt     3660

aaagttctat cttccctttc ccaccttttt tgaccttcca ctagaccatg agcacctggg     3720

cggaaagcca tatatcttat taagctttat atctgctacc tggccgaggg cctaattcat     3780

agtggagaat aaatagtcaa ttgaataaat gaataaatat ctccaccatc gtactaatct     3840

taatcctccc tgcccactcc caccactgaa aatgcaacat tgtacacatc actggttgtt     3900

gggagggact taccttggaa agttgctatt ctaggaaaga gaaaccttca tattcctgga     3960

aacagcaggt agtttccagt gctggcaatg aattccccag aactgctgtt ttggattttt     4020

tcttgcctgg cagctgttgg gagcagggtg cagtgaggat ggggtgagag tgggcagttt     4080

cttgtgcaga tttgcctttc tttcatcctg gggctgactt gcagctccac acccatccat     4140

ctctcaaatt tcacagaggg taaaataggc atttggagag aaagaactct ggcctgattc     4200

ctttctctcc cacaaatgtc ctttattcat aaaacaggaa taataattcc tgtatctccc     4260

aactacatgg aagctgcagc cctcacagaa gaagatgatc tgagaaattc tttgatttcc     4320

tcagtacagt tatacccatg catcataata ctttaagcct ggaaggcatc ttaaaaataa     4380

tgcaacagtc aaacctaatt ttacagagaa actgacatga aatcacgcag ctaatcatga     4440

taaagctggg tggaaaactt atcttgatgg gcagtacagg aagatgcagt agaccttaag     4500

atgtcctgaa agtttcttat ctcaggggaa actcccaggt aggctttatg tcagggacac     4560

agaaaaatgc tccctgaaag tcaaaatatt cgggctagac agacaaattc ctgtaagtgt     4620

ggtttgtctg ggaaccacag atgtcactaa tcctggtttg ctccagagtt ctttttgttc     4680

actcctaccc cccatcacca tttgattgat ctccttaccc tgtaatttcc ccttcttgtc     4740

gcttacctgc agtatctttc ccacccaggc atgccttatt ctttctaaag gaaagtatga     4800

atggagaggg gaaagcttgg gaaactgata gatttccttg gatgccaaaa cacctccata     4860

gcctgtctgc ccggccctat gtggaaacag cattgagttt caagtccttt atgcctccac     4920

ccagggatag ccacttgtaa tccacatggc aattgtgaaa caagcaggaa atgcgtaatt     4980

gtcagaattt tgtggggaaa ggactaggga ataaggaaaa caaagatctt ccttgtgttt     5040

tagagctgtc agctagagga gcacctgctt gagtctgatg ccatctaatg gtcccagaag     5100

aaactgggtt ttgaacctag agttccatgg actcttagga attagactac tactactact     5160

aagcattcac tggtgcttac tatgtgctat tgctgtgcca agtatctgaa acctgtcttc     5220

ttaccttatt tttcaagata attctatgtg gcaggtatta ctatctcaat tctaagagtg     5280

agaaaatgga gttttagaaa catttactaa cttgcctggg tcacatagct aaggaagagg     5340

tggacttgcc cagctttgca taaaactcct caaaagagtt gcctatactc cctgactcca     5400

cttatcttcc tactatcctc tttttaaaat atattattta tttatttaaa taagcaatat     5460

atgaatgtgg tttgaaattc aaaagacaca aagaagtata cagaggaaag cctcactctc     5520

aatccttctc aaggtttgct aattcctctt gcataggcaa tccgttcttc cagctttgtg     5580

tttatctttc cagagaagtt tactgtgtat taagcaaata tgtatatctt tattcttgct     5640

cagtattttc gcaaacagca gctgtctaag ttcactgttc tgaactttat tttttaaatt     5700

aaaaatatat ggctatgtag tattctattt ta                                   5732


<210>  26
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Leu Pro Asp Leu Arg Pro Trp Thr Ser Leu Leu Leu Val Asp 
1               5                   10                  15      


Ala Ala Leu Leu Trp Leu Leu Gln Gly Pro Leu Gly Thr Leu Leu Pro 
            20                  25                  30          


Gln Gly Leu Pro Gly Leu Trp Leu Glu Gly Thr Leu Arg Leu Gly Gly 
        35                  40                  45              


Leu Trp Gly Leu Leu Lys Leu Arg Gly Leu Leu Gly Phe Val Gly Thr 
    50                  55                  60                  


Leu Leu Leu Pro Leu Cys Leu Ala Thr Pro Leu Thr Val Ser Leu Arg 
65                  70                  75                  80  


Ala Leu Val Ala Gly Ala Ser Arg Ala Pro Pro Ala Arg Val Ala Ser 
                85                  90                  95      


Ala Pro Trp Ser Trp Leu Leu Val Gly Tyr Gly Ala Ala Gly Leu Ser 
            100                 105                 110         


Trp Ser Leu Trp Ala Val Leu Ser Pro Pro Gly Ala Gln Glu Lys Glu 
        115                 120                 125             


Gln Asp Gln Val Asn Asn Lys Val Leu Met Trp Arg Leu Leu Lys Leu 
    130                 135                 140                 


Ser Arg Pro Asp Leu Pro Leu Leu Val Ala Ala Phe Phe Phe Leu Val 
145                 150                 155                 160 


Leu Ala Val Leu Gly Glu Thr Leu Ile Pro His Tyr Ser Gly Arg Val 
                165                 170                 175     


Ile Asp Ile Leu Gly Gly Asp Phe Asp Pro His Ala Phe Ala Ser Ala 
            180                 185                 190         


Ile Phe Phe Met Cys Leu Phe Ser Phe Gly Ser Ser Leu Ser Ala Gly 
        195                 200                 205             


Cys Arg Gly Gly Cys Phe Thr Tyr Thr Met Ser Arg Ile Asn Leu Arg 
    210                 215                 220                 


Ile Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Gly Phe 
225                 230                 235                 240 


Phe Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp 
                245                 250                 255     


Thr Thr Leu Met Ser Asn Trp Leu Pro Leu Asn Ala Asn Val Leu Leu 
            260                 265                 270         


Arg Ser Leu Val Lys Val Val Gly Leu Tyr Gly Phe Met Leu Ser Ile 
        275                 280                 285             


Ser Pro Arg Leu Thr Leu Leu Ser Leu Leu His Met Pro Phe Thr Ile 
    290                 295                 300                 


Ala Ala Glu Lys Val Tyr Asn Thr Arg His Gln Glu Val Leu Arg Glu 
305                 310                 315                 320 


Ile Gln Asp Ala Val Ala Arg Ala Gly Gln Val Val Arg Glu Ala Val 
                325                 330                 335     


Gly Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu His Glu Val 
            340                 345                 350         


Cys Arg Tyr Lys Glu Ala Leu Glu Gln Cys Arg Gln Leu Tyr Trp Arg 
        355                 360                 365             


Arg Asp Leu Glu Arg Ala Leu Tyr Leu Leu Val Arg Arg Val Leu His 
    370                 375                 380                 


Leu Gly Val Gln Met Leu Met Leu Ser Cys Gly Leu Gln Gln Met Gln 
385                 390                 395                 400 


Asp Gly Glu Leu Thr Gln Gly Ser Leu Leu Ser Phe Met Ile Tyr Gln 
                405                 410                 415     


Glu Ser Val Gly Ser Tyr Val Gln Thr Leu Val Tyr Ile Tyr Gly Asp 
            420                 425                 430         


Met Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Met Asp 
        435                 440                 445             


Arg Gln Pro Asn Leu Pro Ser Pro Gly Thr Leu Ala Pro Thr Thr Leu 
    450                 455                 460                 


Gln Gly Val Val Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg 
465                 470                 475                 480 


Pro Asp Arg Pro Val Leu Lys Gly Leu Thr Phe Thr Leu Arg Pro Gly 
                485                 490                 495     


Glu Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val 
            500                 505                 510         


Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Val Leu 
        515                 520                 525             


Leu Asp Glu Lys Pro Ile Ser Gln Tyr Glu His Cys Tyr Leu His Ser 
    530                 535                 540                 


Gln Val Val Ser Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val 
545                 550                 555                 560 


Arg Asn Asn Ile Ala Tyr Gly Leu Gln Ser Cys Glu Asp Asp Lys Val 
                565                 570                 575     


Met Ala Ala Ala Gln Ala Ala His Ala Asp Asp Phe Ile Gln Glu Met 
            580                 585                 590         


Glu His Gly Ile Tyr Thr Asp Val Gly Glu Lys Gly Ser Gln Leu Ala 
        595                 600                 605             


Ala Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asp 
    610                 615                 620                 


Pro Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Val Gln 
625                 630                 635                 640 


Cys Glu Gln Ala Leu Gln Asp Trp Asn Ser Arg Gly Asp Arg Thr Val 
                645                 650                 655     


Leu Val Ile Ala His Arg Leu Gln Thr Val Gln Arg Ala His Gln Ile 
            660                 665                 670         


Leu Val Leu Gln Glu Gly Lys Leu Gln Lys Leu Ala Gln Leu 
        675                 680                 685     


<210>  27
<211>  2540
<212>  DNA
<213>  Homo sapiens

<400>  27
gcccgccctg gccgagcgta gctggcggac cagagccggt agcgaggttg ggagagacgg       60

agcggacctc agcgctgaag cagaagtccc cggagctgcg gtctccccgc cgcggctgag      120

ccatgcggct ccctgacctg agaccctgga cctccctgct gctggtggac gcggctttac      180

tgtggctgct tcagggccct ctggggactt tgcttcctca agggctgcca ggactatggc      240

tggaggggac cctgcggctg ggagggctgt gggggctgct aaagctaaga gggctgctgg      300

gatttgtggg gacactgctg ctcccgctct gtctggccac ccccctgact gtctccctga      360

gagccctggt cgcgggggcc tcacgtgctc ccccagccag agtcgcttca gccccttgga      420

gctggctgct ggtggggtac ggggctgcgg ggctcagctg gtcactgtgg gctgttctga      480

gccctcctgg agcccaggag aaggagcagg accaggtgaa caacaaagtc ttgatgtgga      540

ggctgctgaa gctctccagg ccggacctgc ctctcctcgt tgccgccttc ttcttccttg      600

tccttgctgt tttgggtgag acattaatcc ctcactattc tggtcgtgtg attgacatcc      660

tgggaggtga ttttgacccc catgcctttg ccagtgccat cttcttcatg tgcctcttct      720

cctttggcag ctcactgtct gcaggctgcc gaggaggctg cttcacctac accatgtctc      780

gaatcaactt gcggatccgg gagcagcttt tctcctccct gctgcgccag gacctcggtt      840

tcttccagga gactaagaca ggggagctga actcacggct gagctcggat accaccctga      900

tgagtaactg gcttccttta aatgccaatg tgctcttgcg aagcctggtg aaagtggtgg      960

ggctgtatgg cttcatgctc agcatatcgc ctcgactcac cctcctttct ctgctgcaca     1020

tgcccttcac aatagcagcg gagaaggtgt acaacacccg ccatcaggaa gtgcttcggg     1080

agatccagga tgcagtggcc agggcggggc aggtggtgcg ggaagccgtt ggagggctgc     1140

agaccgttcg cagttttggg gccgaggagc atgaagtctg tcgctataaa gaggcccttg     1200

aacaatgtcg gcagctgtat tggcggagag acctggaacg cgccttgtac ctgctcgtaa     1260

ggagggtgct gcacttgggg gtgcagatgc tgatgctgag ctgtgggctg cagcagatgc     1320

aggatgggga gctcacccag ggcagcctgc tttcctttat gatctaccag gagagcgtgg     1380

ggagctatgt gcagaccctg gtatacatat atggggatat gctcagcaac gtgggagctg     1440

cagagaaggt tttctcctac atggaccgac agccaaatct gccttcacct ggcacgcttg     1500

cccccaccac tctgcagggg gttgtgaaat tccaagacgt ctcctttgca tatcccaatc     1560

gccctgacag gcctgtgctc aaggggctga cgtttaccct acgtcctggt gaggtgacgg     1620

cgctggtggg acccaatggg tctgggaaga gcacagtggc tgccctgctg cagaatctgt     1680

accagcccac agggggacag gtgctgctgg atgaaaagcc catctcacag tatgaacact     1740

gctacctgca cagccaggtg gtttcagttg ggcaggagcc tgtgctgttc tccggttctg     1800

tgaggaacaa cattgcttat gggctgcaga gctgcgaaga tgataaggtg atggcggctg     1860

cccaggctgc ccacgcagat gacttcatcc aggaaatgga gcatggaata tacacagatg     1920

taggggagaa gggaagccag ctggctgcgg gacagaaaca acgtctggcc attgcccggg     1980

cccttgtacg agacccgcgg gtcctcatcc tggatgaggc tactagtgcc ctagatgtgc     2040

agtgcgagca ggccaaaacc ctttggaagt tcatgatatt ttgaatttca atggatattt     2100

cctgggaata atgagttcaa atgaacgaat atgtggaaca aagcatcacc aacatttatt     2160

ttttcaggat gaggtgatgg acaaaaccat cacagggaaa ttgaggcaaa tagtacatgt     2220

aaaacaatac ttcgggtgag tccacctatc ccaaagtcgt atcaaagaag tggctgcaga     2280

ttggagccca aagcctttgg ttcctcagtt tccaaatgga ttctcactag gtgggatcat     2340

gagtttgctt tggacacccc aaattctaac tatttctttt gtttcttaca tcctttccct     2400

cttccccagc cccttcccct catgttacac ctcttgctgg tttgagacgt caatcaccac     2460

tgagaaagaa ttaaaccagt attttgagct ggcaaaattc ttagcctagt acaattcctt     2520

caattaaact gtagctcaac                                                 2540


<210>  28
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Leu Pro Asp Leu Arg Pro Trp Thr Ser Leu Leu Leu Val Asp 
1               5                   10                  15      


Ala Ala Leu Leu Trp Leu Leu Gln Gly Pro Leu Gly Thr Leu Leu Pro 
            20                  25                  30          


Gln Gly Leu Pro Gly Leu Trp Leu Glu Gly Thr Leu Arg Leu Gly Gly 
        35                  40                  45              


Leu Trp Gly Leu Leu Lys Leu Arg Gly Leu Leu Gly Phe Val Gly Thr 
    50                  55                  60                  


Leu Leu Leu Pro Leu Cys Leu Ala Thr Pro Leu Thr Val Ser Leu Arg 
65                  70                  75                  80  


Ala Leu Val Ala Gly Ala Ser Arg Ala Pro Pro Ala Arg Val Ala Ser 
                85                  90                  95      


Ala Pro Trp Ser Trp Leu Leu Val Gly Tyr Gly Ala Ala Gly Leu Ser 
            100                 105                 110         


Trp Ser Leu Trp Ala Val Leu Ser Pro Pro Gly Ala Gln Glu Lys Glu 
        115                 120                 125             


Gln Asp Gln Val Asn Asn Lys Val Leu Met Trp Arg Leu Leu Lys Leu 
    130                 135                 140                 


Ser Arg Pro Asp Leu Pro Leu Leu Val Ala Ala Phe Phe Phe Leu Val 
145                 150                 155                 160 


Leu Ala Val Leu Gly Glu Thr Leu Ile Pro His Tyr Ser Gly Arg Val 
                165                 170                 175     


Ile Asp Ile Leu Gly Gly Asp Phe Asp Pro His Ala Phe Ala Ser Ala 
            180                 185                 190         


Ile Phe Phe Met Cys Leu Phe Ser Phe Gly Ser Ser Leu Ser Ala Gly 
        195                 200                 205             


Cys Arg Gly Gly Cys Phe Thr Tyr Thr Met Ser Arg Ile Asn Leu Arg 
    210                 215                 220                 


Ile Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Gly Phe 
225                 230                 235                 240 


Phe Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp 
                245                 250                 255     


Thr Thr Leu Met Ser Asn Trp Leu Pro Leu Asn Ala Asn Val Leu Leu 
            260                 265                 270         


Arg Ser Leu Val Lys Val Val Gly Leu Tyr Gly Phe Met Leu Ser Ile 
        275                 280                 285             


Ser Pro Arg Leu Thr Leu Leu Ser Leu Leu His Met Pro Phe Thr Ile 
    290                 295                 300                 


Ala Ala Glu Lys Val Tyr Asn Thr Arg His Gln Glu Val Leu Arg Glu 
305                 310                 315                 320 


Ile Gln Asp Ala Val Ala Arg Ala Gly Gln Val Val Arg Glu Ala Val 
                325                 330                 335     


Gly Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu His Glu Val 
            340                 345                 350         


Cys Arg Tyr Lys Glu Ala Leu Glu Gln Cys Arg Gln Leu Tyr Trp Arg 
        355                 360                 365             


Arg Asp Leu Glu Arg Ala Leu Tyr Leu Leu Val Arg Arg Val Leu His 
    370                 375                 380                 


Leu Gly Val Gln Met Leu Met Leu Ser Cys Gly Leu Gln Gln Met Gln 
385                 390                 395                 400 


Asp Gly Glu Leu Thr Gln Gly Ser Leu Leu Ser Phe Met Ile Tyr Gln 
                405                 410                 415     


Glu Ser Val Gly Ser Tyr Val Gln Thr Leu Val Tyr Ile Tyr Gly Asp 
            420                 425                 430         


Met Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Met Asp 
        435                 440                 445             


Arg Gln Pro Asn Leu Pro Ser Pro Gly Thr Leu Ala Pro Thr Thr Leu 
    450                 455                 460                 


Gln Gly Val Val Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg 
465                 470                 475                 480 


Pro Asp Arg Pro Val Leu Lys Gly Leu Thr Phe Thr Leu Arg Pro Gly 
                485                 490                 495     


Glu Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val 
            500                 505                 510         


Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Val Leu 
        515                 520                 525             


Leu Asp Glu Lys Pro Ile Ser Gln Tyr Glu His Cys Tyr Leu His Ser 
    530                 535                 540                 


Gln Val Val Ser Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val 
545                 550                 555                 560 


Arg Asn Asn Ile Ala Tyr Gly Leu Gln Ser Cys Glu Asp Asp Lys Val 
                565                 570                 575     


Met Ala Ala Ala Gln Ala Ala His Ala Asp Asp Phe Ile Gln Glu Met 
            580                 585                 590         


Glu His Gly Ile Tyr Thr Asp Val Gly Glu Lys Gly Ser Gln Leu Ala 
        595                 600                 605             


Ala Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asp 
    610                 615                 620                 


Pro Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Val Gln 
625                 630                 635                 640 


Cys Glu Gln Ala Lys Thr Leu Trp Lys Phe Met Ile Phe 
                645                 650             


<210>  29
<211>  2490
<212>  DNA
<213>  Mus musculus

<400>  29
accgcgacca cggcagtgaa gtgaaagcga aagccgcggg acccaggcgc gctccccgcg       60

agggcgtcgc tgcgcaccca ggagatccag tttgagaaga agcagattcc agaagctctc      120

ctgagctgcc gctccgcagc cgcagaaccc accatggcgc tgtcctacct gaggccctgg      180

gtctctctgc tgctggcgga catggcttta cttgggttgc tacaaggatc tctgggaaat      240

ctgcttcccc aggggctgcc aggactctgg atagagggca ccctgcgact tggagtgctg      300

tggggactgc taaaagtggg agagctgctg ggacttgtgg ggacccttct gcccttgctc      360

tgccttgcca ctcccctgtt tttctcgcta agagctctgg tgggaggcac cgcgagcacc      420

tcagtagtcc gagtggcttc tgcctcttgg ggctggctgc tggctggcta tggggctgtt      480

gcgctgagct gggccgtgtg ggctgtgctg agcccggctg gagtccagga gaaggaacca      540

ggccaggaga acagaacact gatgaagcgg ttgctgaagc tgtccaggcc ggacctgcct      600

ttcctcatag ctgccttctt cttccttgtg gtggctgtgt ggggggagac attaatccct      660

cgctattcgg gtcgtgtaat tgacatcctg ggaggtgatt tcgaccccga cgcctttgca      720

agcgccatct ttttcatgtg cctgttctct gttgggagct ccttctctgc aggctgtaga      780

ggaggctcct tcctcttcac catgtccagg atcaacctgc ggatacgaga gcagcttttc      840

tcatctttgt tgcgccaaga ccttggattc ttccaggaga ccaagacagg ggagctgaac      900

tcgaggctga gctctgacac ctctctgatg agccgctggc tccctttcaa tgccaatatc      960

ctgctgcgga gcctggtgaa ggtggtgggg ctctacttct tcatgctcca ggtatcgccc     1020

cgactcacct tcctctccct gctggacctg cccctcacga tagcagctga gaaggtgtac     1080

aacccccgcc atcaggcggt gctaaaggag atccaggatg cagtggccaa ggcggggcag     1140

gtggtgcgcg aggcggtagg agggctgcag actgtgcgaa gctttggggc cgaggagcag     1200

gaagtcagcc actacaagga ggccctggag cgatgtagac agctgtggtg gcgccgagac     1260

ctggaaaaag acgtgtatct agtcatacgg agggtgatgg ccttgggcat gcaggtgctg     1320

attctgaact gcggcgtgca gcagattctg gctggagagg tcacccgggg tggcctgctc     1380

tccttcctgc tgtaccagga ggaagtggga caatatgtcc ggaacctggt ttacatgtac     1440

ggggatatgc tgagcaacgt gggcgctgct gaaaaggtgt tttcctacct ggaccgaaag     1500

ccgaatctgc cccagcctgg gatcctggcc cctccctggc tggaggggcg cgtggaattc     1560

caagacgtct ccttttcgta tcccaggcgc cccgagaagc ctgtgctcca gggtctgacg     1620

ttcaccctgc atcctggaac ggtgacagcg ttggtgggac ccaatggatc agggaagagc     1680

accgtggccg ccctgctgca gaacctgtac cagcccactg ggggccagct gctgctggat     1740

ggcgagcccc tgaccgagta tgatcaccac tacctgcacc gccaggtggt tctggtgggg     1800

caggagcctg tgctgttctc gggttctgtc aaggacaata ttgcctatgg cctgagggac     1860

tgtgaggacg ctcaagtgat ggcagctgcc caggcggcct gtgcagacga cttcataggg     1920

gaaatgacta atggaataaa cacagaaatc ggggaaaaag ggggccagtt agctgtggga     1980

cagaagcaac gtctggccat tgcccgggcc cttgtgcgga acccacgggt cctcatcctg     2040

gatgaggcta ccagcgccct ggacgcccag tgtgaacagg ccctacagaa ctggagatcg     2100

cagggggaca ggacgatgct ggtgattgcc cacaggctgc acacggttca gaatgctgac     2160

caagttctgg tgctcaagca gggacgtctg gtggagcatg accagctcag ggacggccag     2220

gatgtctacg cccacctggt acagcagcgg ctggaggcat gaggcctcca gaccctgagc     2280

ccctctcagg actgtggcca ggatcagacc cacagggacc gtgccggagg aggctagggt     2340

caggataaag attgggaccg ttttggactt tgtgtgtttt tgtggccttg atgggtgagg     2400

gttgggggag tgggtggttt gtggttctag aaacattatt tttttgctga atataaaaat     2460

aataaatata tataaaatgc ttttccttaa                                      2490


<210>  30
<211>  702
<212>  PRT
<213>  Mus musculus

<400>  30

Met Ala Leu Ser Tyr Leu Arg Pro Trp Val Ser Leu Leu Leu Ala Asp 
1               5                   10                  15      


Met Ala Leu Leu Gly Leu Leu Gln Gly Ser Leu Gly Asn Leu Leu Pro 
            20                  25                  30          


Gln Gly Leu Pro Gly Leu Trp Ile Glu Gly Thr Leu Arg Leu Gly Val 
        35                  40                  45              


Leu Trp Gly Leu Leu Lys Val Gly Glu Leu Leu Gly Leu Val Gly Thr 
    50                  55                  60                  


Leu Leu Pro Leu Leu Cys Leu Ala Thr Pro Leu Phe Phe Ser Leu Arg 
65                  70                  75                  80  


Ala Leu Val Gly Gly Thr Ala Ser Thr Ser Val Val Arg Val Ala Ser 
                85                  90                  95      


Ala Ser Trp Gly Trp Leu Leu Ala Gly Tyr Gly Ala Val Ala Leu Ser 
            100                 105                 110         


Trp Ala Val Trp Ala Val Leu Ser Pro Ala Gly Val Gln Glu Lys Glu 
        115                 120                 125             


Pro Gly Gln Glu Asn Arg Thr Leu Met Lys Arg Leu Leu Lys Leu Ser 
    130                 135                 140                 


Arg Pro Asp Leu Pro Phe Leu Ile Ala Ala Phe Phe Phe Leu Val Val 
145                 150                 155                 160 


Ala Val Trp Gly Glu Thr Leu Ile Pro Arg Tyr Ser Gly Arg Val Ile 
                165                 170                 175     


Asp Ile Leu Gly Gly Asp Phe Asp Pro Asp Ala Phe Ala Ser Ala Ile 
            180                 185                 190         


Phe Phe Met Cys Leu Phe Ser Val Gly Ser Ser Phe Ser Ala Gly Cys 
        195                 200                 205             


Arg Gly Gly Ser Phe Leu Phe Thr Met Ser Arg Ile Asn Leu Arg Ile 
    210                 215                 220                 


Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Gly Phe Phe 
225                 230                 235                 240 


Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp Thr 
                245                 250                 255     


Ser Leu Met Ser Arg Trp Leu Pro Phe Asn Ala Asn Ile Leu Leu Arg 
            260                 265                 270         


Ser Leu Val Lys Val Val Gly Leu Tyr Phe Phe Met Leu Gln Val Ser 
        275                 280                 285             


Pro Arg Leu Thr Phe Leu Ser Leu Leu Asp Leu Pro Leu Thr Ile Ala 
    290                 295                 300                 


Ala Glu Lys Val Tyr Asn Pro Arg His Gln Ala Val Leu Lys Glu Ile 
305                 310                 315                 320 


Gln Asp Ala Val Ala Lys Ala Gly Gln Val Val Arg Glu Ala Val Gly 
                325                 330                 335     


Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu Gln Glu Val Ser 
            340                 345                 350         


His Tyr Lys Glu Ala Leu Glu Arg Cys Arg Gln Leu Trp Trp Arg Arg 
        355                 360                 365             


Asp Leu Glu Lys Asp Val Tyr Leu Val Ile Arg Arg Val Met Ala Leu 
    370                 375                 380                 


Gly Met Gln Val Leu Ile Leu Asn Cys Gly Val Gln Gln Ile Leu Ala 
385                 390                 395                 400 


Gly Glu Val Thr Arg Gly Gly Leu Leu Ser Phe Leu Leu Tyr Gln Glu 
                405                 410                 415     


Glu Val Gly Gln Tyr Val Arg Asn Leu Val Tyr Met Tyr Gly Asp Met 
            420                 425                 430         


Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Leu Asp Arg 
        435                 440                 445             


Lys Pro Asn Leu Pro Gln Pro Gly Ile Leu Ala Pro Pro Trp Leu Glu 
    450                 455                 460                 


Gly Arg Val Glu Phe Gln Asp Val Ser Phe Ser Tyr Pro Arg Arg Pro 
465                 470                 475                 480 


Glu Lys Pro Val Leu Gln Gly Leu Thr Phe Thr Leu His Pro Gly Thr 
                485                 490                 495     


Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala 
            500                 505                 510         


Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu Leu 
        515                 520                 525             


Asp Gly Glu Pro Leu Thr Glu Tyr Asp His His Tyr Leu His Arg Gln 
    530                 535                 540                 


Val Val Leu Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val Lys 
545                 550                 555                 560 


Asp Asn Ile Ala Tyr Gly Leu Arg Asp Cys Glu Asp Ala Gln Val Met 
                565                 570                 575     


Ala Ala Ala Gln Ala Ala Cys Ala Asp Asp Phe Ile Gly Glu Met Thr 
            580                 585                 590         


Asn Gly Ile Asn Thr Glu Ile Gly Glu Lys Gly Gly Gln Leu Ala Val 
        595                 600                 605             


Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asn Pro 
    610                 615                 620                 


Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Ala Gln Cys 
625                 630                 635                 640 


Glu Gln Ala Leu Gln Asn Trp Arg Ser Gln Gly Asp Arg Thr Met Leu 
                645                 650                 655     


Val Ile Ala His Arg Leu His Thr Val Gln Asn Ala Asp Gln Val Leu 
            660                 665                 670         


Val Leu Lys Gln Gly Arg Leu Val Glu His Asp Gln Leu Arg Asp Gly 
        675                 680                 685             


Gln Asp Val Tyr Ala His Leu Val Gln Gln Arg Leu Glu Ala 
    690                 695                 700         


<210>  31
<211>  3779
<212>  DNA
<213>  Homo sapiens

<400>  31
ggggacgcgg cacagatagg gggaagccgg agtaatggtt ttcgggcaag tggatgttgg       60

agagcacaca caggagttgg ggggcggggg agggcctggg gttggggagg gctcgaactc      120

ggggctgctg ggtagtccag gagggcgcgg taaggctggg gtgtcctggt gagaactgga      180

gaggatctac ccgggtccct gcctggccag tggggaaaca ccggtccccc aggcaccttc      240

acctaaccag agcggggatt tccaccgccc ctcatgccgc cctttggagg aaagtgaaag      300

tgaaaggagg aagaggaggc ttcatggctg aggaggtcgc agcgccatga agtccctgtc      360

tctgctcctc gctgtggctt tgggcctggc gaccgccgtc tcagcaggac ccgcggtgat      420

cgagtgttgg ttcgtggagg atgcgagcgg aaagggcctg gccaagagac ccggtgcact      480

gctgttgcgc cagggaccgg gggaaccgcc gccccggccg gacctcgacc ctgagctcta      540

tctcagtgta cacgaccccg cgggcgccct ccaggctgcc ttcaggcggt atccccgggg      600

cgcccccgca ccacactgcg agatgagccg cttcgtgcct ctccccgcct ctgcgaaatg      660

ggccagcggc ctgacccccg cgcagaactg cccgcgggcc ctggatgggg cttggctgat      720

ggtcagcata tccagcccag tcctcagcct ctccagcctc ttgcgaccac agccagagcc      780

tcagcaggag cctgttctca tcaccatggc aacagtggta ctgactgtcc tcacccacac      840

ccctgcccct cgagtgagac tgggacaaga tgctctgctg gacttgagct ttgcctacat      900

gccccccacc tccgaggccg cctcatctct ggctccgggt ccccctccct ttgggctaga      960

gtggcgacgc cagcacctgg gtaagggaca tctgctcctg gctgcaactc ctgggctgaa     1020

tggccagatg ccagcagccc aagaaggggc cgtggcattt gctgcttggg atgatgatga     1080

gccatggggc ccatggaccg gaaatgggac cttctggctg cctacagttc aaccctttca     1140

ggagggcacc tatctggcca ccatacacct gccatacctg caaggacagg tcaccctgga     1200

gcttgctgtg tacaaacccc ccaaagtgtc cctgatgcca gcaacccttg cacgggccgc     1260

cccaggggag gcacccccgg aattgctctg ccttgtgtcc cacttctacc cttctggggg     1320

cctggaggtg gagtgggaac tccggggtgg cccagggggc cgctctcaga aggccgaggg     1380

gcagaggtgg ctctcggccc tgcgccacca ttccgatggc tctgtcagcc tctctgggca     1440

cttgcagccg cccccagtca ccactgagca gcatggggca cgctatgcct gtcgaattca     1500

ccatcccagc ctgcctgcct cggggcgcag cgctgaggtc accctggagg tagcaggtct     1560

ttcagggccc tcccttgagg acagcgtagg ccttttcctg tctgcctttc ttctgcttgg     1620

gctcttcaag gcactgggct gggctgctgt ctacctgtcc acctgcaagg attcaaagaa     1680

gaaagcagag tgagggcact cactgccatc ctgtggaagc caccatcatc tctggcccaa     1740

gcttctgtag tagctcccta aaataatacc ctatcatctg ctcctaatcc ctccaatctc     1800

tctccactga gtggctggaa tgcttttttt tttttctttc acttatataa gggataattt     1860

ttcttttttt tttttttttg agacggagtc tcactcttcc gcccaggctg cagtgcagtg     1920

gcatgatctt ggcttactgc aacctccgcc tcctgggttc aagcaattct gtggcttcag     1980

cctccggagt agctgggatt acaggcacat gccaccacac ccagtgaatt tttgtatttt     2040

tagtagagac ggggtttcac catgttggcc aggctggtct tgaattcctg acctcaggtg     2100

atctgcccac ctcagcctcc caaagtgctg ggattacagg cgtgagccac cacaccaggc     2160

ccgagaaatg cttttttaaa aaacacacat cttatggcat tcaccttctt ggagctctag     2220

gacagtggtt ctcaaaattt ttttctctca ggacctctta aaaatcatca aggaccccaa     2280

aaagcttttg ggtatgtggg ttatagctat caatatttat ggtactagaa cttaaaagtg     2340

agaaaaattt aaaacacgag aatacatagg cacacattct attcatcgtg ggaaccatgg     2400

tgtcaataca tatcatgtag cttctgaaaa actccactgt acacttatag aatgaagaag     2460

gcaaaaaact tttttttttt tttttttgag acggagtctc gctctgtcgc ccaggctgga     2520

gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc tcgggttcac gccattctcc     2580

tgcctcagcc tcccaagtag ctcggactac aggcgtcctc caccatgcct ggctaatatt     2640

ttgtattttt tagtagagac ggggtttcac cgtgttagcc aggatggtct cgatctccta     2700

acctggtgat ccgcccgcct cggcctccca aagtattggg attacccgcg tgagccaccg     2760

cgcccggctg caaataatct ttcttttttt ctgagacaga gtctcgctct gttgcccagg     2820

ctggagtgca gtggcacgat ctcggctcac ggcacgctcc gcctcccggg ttcacgccat     2880

tctcctgcct cagcttcccg agtagctggg actacagggg cccgccacca cgcccggcta     2940

actttttgtg tttttagtag agacggggtt tcaccgtgtt agccaggatg gtctcgatct     3000

cctgaccttg tgatctgccc gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc     3060

accgcgcccg gcggcgaaac acgatattgt actaacatct taattttgtt ataaaatctc     3120

acaaaccccc tgacatagtc tcagagatct gtagggccga ggttacattt ggagaacccg     3180

tactctaggg ccaaatccat tcttcttgcc ctggctcact tgtccccccc accgccccgc     3240

gctggagcca ctgcctagtt cttcagccct agatggtgct cgccagacct cctctcaatg     3300

ctcatcacac acagggctat tcctttcctc caatgaacca aacgcctccc gcccacctcc     3360

aggtcccagt cctctgttcc ctttgcctgg tccacccttg ccctccctgg gtcgcagacg     3420

aggtcggcct cgtcattccc cgcagaccgc cgcgcgtccc tcttgtgcgg ttcaccacag     3480

ttgtatttaa gtgatcgtgt gagtcgtcgt taaatgcctg tctccccgcg gatcatgggc     3540

tcctcgagga cagggactgg cctgtctgtc cactgctgta accccgcgcc ggcataggga     3600

cctaaggccc actggagggc gctcatcaag tagctgctgg atgttgacga aggaagcggc     3660

ggcgcagctc agggatctcc gagtcaggac ggtcggccag acccacgggg taacgggtct     3720

aatcgtgtag gaataaagct gtattccagt gcttccaaaa aaaaaaaaaa aaaaaaaaa      3779


<210>  32
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Asp Pro Ala Gly Ala Leu Gln Ala Ala Phe Arg 
65                  70                  75                  80  


Arg Tyr Pro Arg Gly Ala Pro Ala Pro His Cys Glu Met Ser Arg Phe 
                85                  90                  95      


Val Pro Leu Pro Ala Ser Ala Lys Trp Ala Ser Gly Leu Thr Pro Ala 
            100                 105                 110         


Gln Asn Cys Pro Arg Ala Leu Asp Gly Ala Trp Leu Met Val Ser Ile 
        115                 120                 125             


Ser Ser Pro Val Leu Ser Leu Ser Ser Leu Leu Arg Pro Gln Pro Glu 
    130                 135                 140                 


Pro Gln Gln Glu Pro Val Leu Ile Thr Met Ala Thr Val Val Leu Thr 
145                 150                 155                 160 


Val Leu Thr His Thr Pro Ala Pro Arg Val Arg Leu Gly Gln Asp Ala 
                165                 170                 175     


Leu Leu Asp Leu Ser Phe Ala Tyr Met Pro Pro Thr Ser Glu Ala Ala 
            180                 185                 190         


Ser Ser Leu Ala Pro Gly Pro Pro Pro Phe Gly Leu Glu Trp Arg Arg 
        195                 200                 205             


Gln His Leu Gly Lys Gly His Leu Leu Leu Ala Ala Thr Pro Gly Leu 
    210                 215                 220                 


Asn Gly Gln Met Pro Ala Ala Gln Glu Gly Ala Val Ala Phe Ala Ala 
225                 230                 235                 240 


Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn Gly Thr Phe 
                245                 250                 255     


Trp Leu Pro Thr Val Gln Pro Phe Gln Glu Gly Thr Tyr Leu Ala Thr 
            260                 265                 270         


Ile His Leu Pro Tyr Leu Gln Gly Gln Val Thr Leu Glu Leu Ala Val 
        275                 280                 285             


Tyr Lys Pro Pro Lys Val Ser Leu Met Pro Ala Thr Leu Ala Arg Ala 
    290                 295                 300                 


Ala Pro Gly Glu Ala Pro Pro Glu Leu Leu Cys Leu Val Ser His Phe 
305                 310                 315                 320 


Tyr Pro Ser Gly Gly Leu Glu Val Glu Trp Glu Leu Arg Gly Gly Pro 
                325                 330                 335     


Gly Gly Arg Ser Gln Lys Ala Glu Gly Gln Arg Trp Leu Ser Ala Leu 
            340                 345                 350         


Arg His His Ser Asp Gly Ser Val Ser Leu Ser Gly His Leu Gln Pro 
        355                 360                 365             


Pro Pro Val Thr Thr Glu Gln His Gly Ala Arg Tyr Ala Cys Arg Ile 
    370                 375                 380                 


His His Pro Ser Leu Pro Ala Ser Gly Arg Ser Ala Glu Val Thr Leu 
385                 390                 395                 400 


Glu Val Ala Gly Leu Ser Gly Pro Ser Leu Glu Asp Ser Val Gly Leu 
                405                 410                 415     


Phe Leu Ser Ala Phe Leu Leu Leu Gly Leu Phe Lys Ala Leu Gly Trp 
            420                 425                 430         


Ala Ala Val Tyr Leu Ser Thr Cys Lys Asp Ser Lys Lys Lys Ala Glu 
        435                 440                 445             


<210>  33
<211>  2003
<212>  DNA
<213>  Homo sapiens

<400>  33
ggggacgcgg cacagatagg gggaagccgg agtaatggtt ttcgggcaag tggatgttgg       60

agagcacaca caggagttgg ggggcggggg agggcctggg gttggggagg gctcgaactc      120

ggggctgctg ggtagtccag gagggcgcgg taaggctggg gtgtcctggt gagaactgga      180

gaggatctac ccgggtccct gcctggccag tggggaaaca ccggtccccc aggcaccttc      240

acctaaccag agcggggatt tccaccgccc ctcatgccgc cctttggagg aaagtgaaag      300

tgaaaggagg aagaggaggc ttcatggctg aggaggtcgc agcgccatga agtccctgtc      360

tctgctcctc gctgtggctt tgggcctggc gaccgccgtc tcagcaggac ccgcggtgat      420

cgagtgttgg ttcgtggagg atgcgagcgg aaagggcctg gccaagagac ccggtgcact      480

gctgttgcgc cagggaccgg gggaaccgcc gccccggccg gacctcgacc ctgagctcta      540

tctcagtgta cacgaccccg cgggcgccct ccaggctgcc ttcaggcggt atccccgggg      600

cgcccccgca ccacactgcg agatgagccg cttcgtgcct ctccccgcct ctgcgaaatg      660

ggccagcggc ctgacccccg cgcagaactg cccgcgggcc ctggatgggg cttggctgat      720

ggtcagcata tccagcccag tcctcagcct ctccagcctc ttgcgaccac agccagagcc      780

tcagcaggag cctgttctca tcaccatggc aacagtggta ctgactgtcc tcacccacac      840

ccctgcccct cgagtgagac tgggacaaga tgctctgctg gacttgagct ttgcctacat      900

gccccccacc tccgaggccg cctcatctct ggctccgggt ccccctccct ttgggctaga      960

gtggcgacgc cagcacctgg gtaagggaca tctgctcctg gctgcaactc ctgggctgaa     1020

tggccagatg ccagcagccc aagaaggggc cgtggcattt gctgcttggg atgatgatga     1080

gccatggggc ccatggaccg gaaatgggac cttctggctg cctacagttc aaccctttca     1140

ggagggcacc tatctggcca ccatacacct gccatacctg caaggacagg tcaccctgga     1200

gcttgctgtg tacaaacccc ccaaagtgtc cctgatgcca gcaacccttg cacgggccgc     1260

cccaggggag gcacccccgg aattgctctg ccttgtgtcc cacttctacc cttctggggg     1320

cctggaggtg gagtgggaac tccggggtgg cccagggggc cgctctcaga aggccgaggg     1380

gcagaggtgg ctctcggccc tgcgccacca ttccgatggc tctgtcagcc tctctgggca     1440

cttgcagccg cccccagtca ccactgagca gcatggggca cgctatgcct gtcgaattca     1500

ccatcccagc ctgcctgcct cggggcgcag cgctgaggtc accctggagg tagcaggtct     1560

ttcagggccc tcccttgagg acagcgtagg ccttttcctg tctgcctttc ttctgcttgg     1620

gctcttcaag gcactgggct gggctgctgt ctacctgtcc acctgcaagg attcaaagaa     1680

ggtacagtgc tccacctctc tgtatctttc ccttgtcact ttatctcctc atcctatctc     1740

aaaacccatg gagggaggct gctggtgtgg taggcagaac ctaggcttgg aattcacact     1800

gatctgggtt aaaacctggc actatatcct aactgtagga ctctttgagc atgctactta     1860

atctatatgt ttccttgggt gtagggattt taaaaagtta cttaggcagt gctgtccaat     1920

agaaagataa tgcaagccac atatgtaaat ttaaatactc tagtactcac attaaaaaaa     1980

taagcagaaa caggtaaaat taa                                             2003


<210>  34
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Asp Pro Ala Gly Ala Leu Gln Ala Ala Phe Arg 
65                  70                  75                  80  


Arg Tyr Pro Arg Gly Ala Pro Ala Pro His Cys Glu Met Ser Arg Phe 
                85                  90                  95      


Val Pro Leu Pro Ala Ser Ala Lys Trp Ala Ser Gly Leu Thr Pro Ala 
            100                 105                 110         


Gln Asn Cys Pro Arg Ala Leu Asp Gly Ala Trp Leu Met Val Ser Ile 
        115                 120                 125             


Ser Ser Pro Val Leu Ser Leu Ser Ser Leu Leu Arg Pro Gln Pro Glu 
    130                 135                 140                 


Pro Gln Gln Glu Pro Val Leu Ile Thr Met Ala Thr Val Val Leu Thr 
145                 150                 155                 160 


Val Leu Thr His Thr Pro Ala Pro Arg Val Arg Leu Gly Gln Asp Ala 
                165                 170                 175     


Leu Leu Asp Leu Ser Phe Ala Tyr Met Pro Pro Thr Ser Glu Ala Ala 
            180                 185                 190         


Ser Ser Leu Ala Pro Gly Pro Pro Pro Phe Gly Leu Glu Trp Arg Arg 
        195                 200                 205             


Gln His Leu Gly Lys Gly His Leu Leu Leu Ala Ala Thr Pro Gly Leu 
    210                 215                 220                 


Asn Gly Gln Met Pro Ala Ala Gln Glu Gly Ala Val Ala Phe Ala Ala 
225                 230                 235                 240 


Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn Gly Thr Phe 
                245                 250                 255     


Trp Leu Pro Thr Val Gln Pro Phe Gln Glu Gly Thr Tyr Leu Ala Thr 
            260                 265                 270         


Ile His Leu Pro Tyr Leu Gln Gly Gln Val Thr Leu Glu Leu Ala Val 
        275                 280                 285             


Tyr Lys Pro Pro Lys Val Ser Leu Met Pro Ala Thr Leu Ala Arg Ala 
    290                 295                 300                 


Ala Pro Gly Glu Ala Pro Pro Glu Leu Leu Cys Leu Val Ser His Phe 
305                 310                 315                 320 


Tyr Pro Ser Gly Gly Leu Glu Val Glu Trp Glu Leu Arg Gly Gly Pro 
                325                 330                 335     


Gly Gly Arg Ser Gln Lys Ala Glu Gly Gln Arg Trp Leu Ser Ala Leu 
            340                 345                 350         


Arg His His Ser Asp Gly Ser Val Ser Leu Ser Gly His Leu Gln Pro 
        355                 360                 365             


Pro Pro Val Thr Thr Glu Gln His Gly Ala Arg Tyr Ala Cys Arg Ile 
    370                 375                 380                 


His His Pro Ser Leu Pro Ala Ser Gly Arg Ser Ala Glu Val Thr Leu 
385                 390                 395                 400 


Glu Val Ala Gly Leu Ser Gly Pro Ser Leu Glu Asp Ser Val Gly Leu 
                405                 410                 415     


Phe Leu Ser Ala Phe Leu Leu Leu Gly Leu Phe Lys Ala Leu Gly Trp 
            420                 425                 430         


Ala Ala Val Tyr Leu Ser Thr Cys Lys Asp Ser Lys Lys Val Gln Cys 
        435                 440                 445             


Ser Thr Ser Leu Tyr Leu Ser Leu Val Thr Leu Ser Pro His Pro Ile 
    450                 455                 460                 


Ser Lys Pro Met Glu Gly Gly Cys Trp Cys Gly Arg Gln Asn Leu Gly 
465                 470                 475                 480 


Leu Glu Phe Thr Leu Ile Trp Val Lys Thr Trp His Tyr Ile Leu Thr 
                485                 490                 495     


Val Gly Leu Phe Glu His Ala Thr 
            500                 


<210>  35
<211>  3518
<212>  DNA
<213>  Homo sapiens

<400>  35
ggggacgcgg cacagatagg gggaagccgg agtaatggtt ttcgggcaag tggatgttgg       60

agagcacaca caggagttgg ggggcggggg agggcctggg gttggggagg gctcgaactc      120

ggggctgctg ggtagtccag gagggcgcgg taaggctggg gtgtcctggt gagaactgga      180

gaggatctac ccgggtccct gcctggccag tggggaaaca ccggtccccc aggcaccttc      240

acctaaccag agcggggatt tccaccgccc ctcatgccgc cctttggagg aaagtgaaag      300

tgaaaggagg aagaggaggc ttcatggctg aggaggtcgc agcgccatga agtccctgtc      360

tctgctcctc gctgtggctt tgggcctggc gaccgccgtc tcagcaggac ccgcggtgat      420

cgagtgttgg ttcgtggagg atgcgagcgg aaagggcctg gccaagagac ccggtgcact      480

gctgttgcgc cagggaccgg gggaaccgcc gccccggccg gacctcgacc ctgagctcta      540

tctcagtgta cacgtggtac tgactgtcct cacccacacc cctgcccctc gagtgagact      600

gggacaagat gctctgctgg acttgagctt tgcctacatg ccccccacct ccgaggccgc      660

ctcatctctg gctccgggtc cccctccctt tgggctagag tggcgacgcc agcacctggg      720

taagggacat ctgctcctgg ctgcaactcc tgggctgaat ggccagatgc cagcagccca      780

agaaggggcc gtggcatttg ctgcttggga tgatgatgag ccatggggcc catggaccgg      840

aaatgggacc ttctggctgc ctacagttca accctttcag gagggcacct atctggccac      900

catacacctg ccatacctgc aaggacaggt caccctggag cttgctgtgt acaaaccccc      960

caaagtgtcc ctgatgccag caacccttgc acgggccgcc ccaggggagg cacccccgga     1020

attgctctgc cttgtgtccc acttctaccc ttctgggggc ctggaggtgg agtgggaact     1080

ccggggtggc ccagggggcc gctctcagaa ggccgagggg cagaggtggc tctcggccct     1140

gcgccaccat tccgatggct ctgtcagcct ctctgggcac ttgcagccgc ccccagtcac     1200

cactgagcag catggggcac gctatgcctg tcgaattcac catcccagcc tgcctgcctc     1260

ggggcgcagc gctgaggtca ccctggaggt agcaggtctt tcagggccct cccttgagga     1320

cagcgtaggc cttttcctgt ctgcctttct tctgcttggg ctcttcaagg cactgggctg     1380

ggctgctgtc tacctgtcca cctgcaagga ttcaaagaag aaagcagagt gagggcactc     1440

actgccatcc tgtggaagcc accatcatct ctggcccaag cttctgtagt agctccctaa     1500

aataataccc tatcatctgc tcctaatccc tccaatctct ctccactgag tggctggaat     1560

gctttttttt ttttctttca cttatataag ggataatttt tctttttttt ttttttttga     1620

gacggagtct cactcttccg cccaggctgc agtgcagtgg catgatcttg gcttactgca     1680

acctccgcct cctgggttca agcaattctg tggcttcagc ctccggagta gctgggatta     1740

caggcacatg ccaccacacc cagtgaattt ttgtattttt agtagagacg gggtttcacc     1800

atgttggcca ggctggtctt gaattcctga cctcaggtga tctgcccacc tcagcctccc     1860

aaagtgctgg gattacaggc gtgagccacc acaccaggcc cgagaaatgc ttttttaaaa     1920

aacacacatc ttatggcatt caccttcttg gagctctagg acagtggttc tcaaaatttt     1980

tttctctcag gacctcttaa aaatcatcaa ggaccccaaa aagcttttgg gtatgtgggt     2040

tatagctatc aatatttatg gtactagaac ttaaaagtga gaaaaattta aaacacgaga     2100

atacataggc acacattcta ttcatcgtgg gaaccatggt gtcaatacat atcatgtagc     2160

ttctgaaaaa ctccactgta cacttataga atgaagaagg caaaaaactt tttttttttt     2220

ttttttgaga cggagtctcg ctctgtcgcc caggctggag tgcagtggcg cgatctcggc     2280

tcactgcaag ctccgcctct cgggttcacg ccattctcct gcctcagcct cccaagtagc     2340

tcggactaca ggcgtcctcc accatgcctg gctaatattt tgtatttttt agtagagacg     2400

gggtttcacc gtgttagcca ggatggtctc gatctcctaa cctggtgatc cgcccgcctc     2460

ggcctcccaa agtattggga ttacccgcgt gagccaccgc gcccggctgc aaataatctt     2520

tctttttttc tgagacagag tctcgctctg ttgcccaggc tggagtgcag tggcacgatc     2580

tcggctcacg gcacgctccg cctcccgggt tcacgccatt ctcctgcctc agcttcccga     2640

gtagctggga ctacaggggc ccgccaccac gcccggctaa ctttttgtgt ttttagtaga     2700

gacggggttt caccgtgtta gccaggatgg tctcgatctc ctgaccttgt gatctgcccg     2760

cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgcgcccgg cggcgaaaca     2820

cgatattgta ctaacatctt aattttgtta taaaatctca caaaccccct gacatagtct     2880

cagagatctg tagggccgag gttacatttg gagaacccgt actctagggc caaatccatt     2940

cttcttgccc tggctcactt gtccccccca ccgccccgcg ctggagccac tgcctagttc     3000

ttcagcccta gatggtgctc gccagacctc ctctcaatgc tcatcacaca cagggctatt     3060

cctttcctcc aatgaaccaa acgcctcccg cccacctcca ggtcccagtc ctctgttccc     3120

tttgcctggt ccacccttgc cctccctggg tcgcagacga ggtcggcctc gtcattcccc     3180

gcagaccgcc gcgcgtccct cttgtgcggt tcaccacagt tgtatttaag tgatcgtgtg     3240

agtcgtcgtt aaatgcctgt ctccccgcgg atcatgggct cctcgaggac agggactggc     3300

ctgtctgtcc actgctgtaa ccccgcgccg gcatagggac ctaaggccca ctggagggcg     3360

ctcatcaagt agctgctgga tgttgacgaa ggaagcggcg gcgcagctca gggatctccg     3420

agtcaggacg gtcggccaga cccacggggt aacgggtcta atcgtgtagg aataaagctg     3480

tattccagtg cttccaaaaa aaaaaaaaaa aaaaaaaa                             3518


<210>  36
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Val Val Leu Thr Val Leu Thr His Thr Pro Ala 
65                  70                  75                  80  


Pro Arg Val Arg Leu Gly Gln Asp Ala Leu Leu Asp Leu Ser Phe Ala 
                85                  90                  95      


Tyr Met Pro Pro Thr Ser Glu Ala Ala Ser Ser Leu Ala Pro Gly Pro 
            100                 105                 110         


Pro Pro Phe Gly Leu Glu Trp Arg Arg Gln His Leu Gly Lys Gly His 
        115                 120                 125             


Leu Leu Leu Ala Ala Thr Pro Gly Leu Asn Gly Gln Met Pro Ala Ala 
    130                 135                 140                 


Gln Glu Gly Ala Val Ala Phe Ala Ala Trp Asp Asp Asp Glu Pro Trp 
145                 150                 155                 160 


Gly Pro Trp Thr Gly Asn Gly Thr Phe Trp Leu Pro Thr Val Gln Pro 
                165                 170                 175     


Phe Gln Glu Gly Thr Tyr Leu Ala Thr Ile His Leu Pro Tyr Leu Gln 
            180                 185                 190         


Gly Gln Val Thr Leu Glu Leu Ala Val Tyr Lys Pro Pro Lys Val Ser 
        195                 200                 205             


Leu Met Pro Ala Thr Leu Ala Arg Ala Ala Pro Gly Glu Ala Pro Pro 
    210                 215                 220                 


Glu Leu Leu Cys Leu Val Ser His Phe Tyr Pro Ser Gly Gly Leu Glu 
225                 230                 235                 240 


Val Glu Trp Glu Leu Arg Gly Gly Pro Gly Gly Arg Ser Gln Lys Ala 
                245                 250                 255     


Glu Gly Gln Arg Trp Leu Ser Ala Leu Arg His His Ser Asp Gly Ser 
            260                 265                 270         


Val Ser Leu Ser Gly His Leu Gln Pro Pro Pro Val Thr Thr Glu Gln 
        275                 280                 285             


His Gly Ala Arg Tyr Ala Cys Arg Ile His His Pro Ser Leu Pro Ala 
    290                 295                 300                 


Ser Gly Arg Ser Ala Glu Val Thr Leu Glu Val Ala Gly Leu Ser Gly 
305                 310                 315                 320 


Pro Ser Leu Glu Asp Ser Val Gly Leu Phe Leu Ser Ala Phe Leu Leu 
                325                 330                 335     


Leu Gly Leu Phe Lys Ala Leu Gly Trp Ala Ala Val Tyr Leu Ser Thr 
            340                 345                 350         


Cys Lys Asp Ser Lys Lys Lys Ala Glu 
        355                 360     


<210>  37
<211>  2750
<212>  DNA
<213>  Mus musculus

<400>  37
caagggggtg ggtgcagggc gaggagtggc tggagagcta cagacagggt ttcggcaact       60

ctgtttggcc cctgtgggcg gcgttcctcc aacgcgcagt cacgccctca cctgaccaga      120

tcggggaatt tccagttcct caccccagcc ttagaaggaa aatgaaagtg aaaggggaag      180

aaaagacttg gtaggagaga tcgtagcacc atgaagcctc tgctcctgct cgtcgctgtg      240

gcactgggcc tagcgaccgt cgtctccgtc gtctcggctg gaccagaggc gatcgagtgc      300

tggttcgtgg aggatgcagg tgggggtggc ctgtctaaga aacctgccac actgctactg      360

cgccatggac ccaggggacc gccgccccgg ccagatcttg acccaaagct atacttcaag      420

gtggatgacc cggcgggaat gctcctggcc gccttcaggc ggtaccccgc aggcgcctcc      480

gccccacact gcgagatgag ccgcttcatc ccgttccctg cctcggcgaa gtgggctaga      540

agtctgagtc cggagcagaa ctgcccgcgg gccctggacg gggattggct gctggtcagc      600

gtatccagca ctctcttcag cctctccagc ctgctgcgac cacagccgga gcctctgcgg      660

gagcctgtcg tcatcaccat ggcaacagtg gtgctgaccg tcctcaccca taaccctgcc      720

cctcgagtcc agctgggaaa ggatgcagtg ctggacctgc gcttcgccta cgcaccctcc      780

gccctggaag gttctccctc tctggacgca ggccctcctc cctttgggct ggagtggcga      840

cgccagcaca ggggaaaggg tcacctgctg ttggctgcca cccccgggct ggccgggaga      900

atgccaccag cccaggaaaa ggctacggca tttgcagctt gggatgacga tgagccctgg      960

ggcccgtgga ctgggaatgg gaccttctgg cttccagccg tgaagccttc tcaggagggt     1020

gtctacctgg ctacggtaca cctgccctac ctgcaaggac aggtctccct ggagctgact     1080

gtgcacaagg cccccagagt gtctctaaca ccagcacccg ttgtgtgggc tgccccagga     1140

gaggcacccc cagaactgct ctgtcttgca tcccacttct tccctgcgga gggtctggag     1200

gtcaagtggg agctcagagg cggcccagga ggaagttcta gaaaggttga ggggaagacg     1260

tggctctcca ccatccgcca ccattccgat ggctctgtca gccagtctgg gcacctgcag     1320

ctacctccag tcactgccaa gcagcatgga gttcactatg tctgtcgggt gtaccactct     1380

agcctgccag catcggggcg cagtgctgac gtcaccctgg aggtggcagg cttctcaggg     1440

ccctccatcg aggacggcat cggcctgttc ctgtctgctt ttctcctcct cggactcctc     1500

aaggtgctag gctggctggt agctgcctac tggaccattc ctgaagtctc aaaggagaag     1560

gccacagctg ccagcctgac cattcccagg aactcaaaga agtcacagta aagaagttct     1620

cgtctgtgga agccaccctc atctctggcc cagatgactc cagtagcccc tgccccagaa     1680

caacagcctt cttctcttct tctccctcca ttgaatagct cggatttttt tttttaaggt     1740

ttttttgttt gtttcaatct ttcttgtttt gttcttgttt ttagacaagg tctctctatg     1800

tagccttggc tggctgtcct gaaccctcac caagccaacc aggctggcct cgaagtccca     1860

gagatccacc tgtccctctg cctcggagtg acaaacggca ctggacacca tgcctagagg     1920

tctttttttt ttttggtttt tggagacagg atttctctgt atagtcccgg ctgtcctgga     1980

actcactctg tagaccaggc tggcctcgaa ctcagaaatc cgcctgcctc tgcctcccag     2040

gtgctgggat taaaggcgtg cgccaccacc gctggactcg aactaaactt ttaagatgag     2100

aaaaaagcga gacttagcgc cacactcatt tgatgcccac agtcgggagg cagaggcagt     2160

ggatctctga catttccatg ccagcctgat ctacaaatag ggagtttcag gtcagtcggg     2220

gttacttggc ggggctttgt tgagagaact aaatataaga acacacatgc gtagagtccc     2280

agggttgaga agaaccagtg tatgcgccag agaggcgggt tcataacctg tggctcacaa     2340

ccccctttaa gtccatcgga aataccagac attaggattc acaacagtag taaaggcagt     2400

tacgaagtag caaagaaaat aattttacaa cttgaactgc gttaatgtta agaaggttga     2460

gaaccactgg ccaggggatt aggacgaaag gtcttcatag catcttaaga ttctagagac     2520

ctcagggaca gcccacagca gtagtctaga gacggaaagg tccatgtgtc tccctcgcgg     2580

actaaagcct acctctccag ctctccattc ctaccacagc ttttcttttg cctggtccac     2640

ctttaccatc tccgggcctg gtgggtctcg gccctttacg aatgtccccg tgtggttcgt     2700

cctctcctgt tcgccggtcc tcgtgagcta ataaagtctt tccgagtttc                2750


<210>  38
<211>  466
<212>  PRT
<213>  Mus musculus

<400>  38

Met Lys Pro Leu Leu Leu Leu Val Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Val Val Ser Val Val Ser Ala Gly Pro Glu Ala Ile Glu Cys Trp Phe 
            20                  25                  30          


Val Glu Asp Ala Gly Gly Gly Gly Leu Ser Lys Lys Pro Ala Thr Leu 
        35                  40                  45              


Leu Leu Arg His Gly Pro Arg Gly Pro Pro Pro Arg Pro Asp Leu Asp 
    50                  55                  60                  


Pro Lys Leu Tyr Phe Lys Val Asp Asp Pro Ala Gly Met Leu Leu Ala 
65                  70                  75                  80  


Ala Phe Arg Arg Tyr Pro Ala Gly Ala Ser Ala Pro His Cys Glu Met 
                85                  90                  95      


Ser Arg Phe Ile Pro Phe Pro Ala Ser Ala Lys Trp Ala Arg Ser Leu 
            100                 105                 110         


Ser Pro Glu Gln Asn Cys Pro Arg Ala Leu Asp Gly Asp Trp Leu Leu 
        115                 120                 125             


Val Ser Val Ser Ser Thr Leu Phe Ser Leu Ser Ser Leu Leu Arg Pro 
    130                 135                 140                 


Gln Pro Glu Pro Leu Arg Glu Pro Val Val Ile Thr Met Ala Thr Val 
145                 150                 155                 160 


Val Leu Thr Val Leu Thr His Asn Pro Ala Pro Arg Val Gln Leu Gly 
                165                 170                 175     


Lys Asp Ala Val Leu Asp Leu Arg Phe Ala Tyr Ala Pro Ser Ala Leu 
            180                 185                 190         


Glu Gly Ser Pro Ser Leu Asp Ala Gly Pro Pro Pro Phe Gly Leu Glu 
        195                 200                 205             


Trp Arg Arg Gln His Arg Gly Lys Gly His Leu Leu Leu Ala Ala Thr 
    210                 215                 220                 


Pro Gly Leu Ala Gly Arg Met Pro Pro Ala Gln Glu Lys Ala Thr Ala 
225                 230                 235                 240 


Phe Ala Ala Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn 
                245                 250                 255     


Gly Thr Phe Trp Leu Pro Ala Val Lys Pro Ser Gln Glu Gly Val Tyr 
            260                 265                 270         


Leu Ala Thr Val His Leu Pro Tyr Leu Gln Gly Gln Val Ser Leu Glu 
        275                 280                 285             


Leu Thr Val His Lys Ala Pro Arg Val Ser Leu Thr Pro Ala Pro Val 
    290                 295                 300                 


Val Trp Ala Ala Pro Gly Glu Ala Pro Pro Glu Leu Leu Cys Leu Ala 
305                 310                 315                 320 


Ser His Phe Phe Pro Ala Glu Gly Leu Glu Val Lys Trp Glu Leu Arg 
                325                 330                 335     


Gly Gly Pro Gly Gly Ser Ser Arg Lys Val Glu Gly Lys Thr Trp Leu 
            340                 345                 350         


Ser Thr Ile Arg His His Ser Asp Gly Ser Val Ser Gln Ser Gly His 
        355                 360                 365             


Leu Gln Leu Pro Pro Val Thr Ala Lys Gln His Gly Val His Tyr Val 
    370                 375                 380                 


Cys Arg Val Tyr His Ser Ser Leu Pro Ala Ser Gly Arg Ser Ala Asp 
385                 390                 395                 400 


Val Thr Leu Glu Val Ala Gly Phe Ser Gly Pro Ser Ile Glu Asp Gly 
                405                 410                 415     


Ile Gly Leu Phe Leu Ser Ala Phe Leu Leu Leu Gly Leu Leu Lys Val 
            420                 425                 430         


Leu Gly Trp Leu Val Ala Ala Tyr Trp Thr Ile Pro Glu Val Ser Lys 
        435                 440                 445             


Glu Lys Ala Thr Ala Ala Ser Leu Thr Ile Pro Arg Asn Ser Lys Lys 
    450                 455                 460                 


Ser Gln 
465     


<210>  39
<211>  2747
<212>  DNA
<213>  Mus musculus

<400>  39
caagggggtg ggtgcagggc gaggagtggc tggagagcta cagacagggt ttcggcaact       60

ctgtttggcc cctgtgggcg gcgttcctcc aacgcgcagt cacgccctca cctgaccaga      120

tcggggaatt tccagttcct caccccagcc ttagaaggaa aatgaaagtg aaaggggaag      180

aaaagacttg gtaggagaga tcgtagcacc atgaagcctc tgctcctgct cgtcgctgtg      240

gcactgggcc tagcgaccgt cgtctccgtc gtctcggctg gaccagaggc gatcgagtgc      300

tggttcgtgg aggatgcagg tgggggtggc ctgtctaaga aacctgccac actgctactg      360

cgccatggac ccaggggacc gccgccccgg ccagatcttg acccaaagct atacttcaag      420

gtggatgacc cggcgggaat gctcctggcc gccttcaggc ggtaccccgc aggcgcctcc      480

gccccacact gcgagatgag ccgcttcatc ccgttccctg cctcggcgaa gtgggctaga      540

agtctgagtc cggagcagaa ctgcccgcgg gccctggacg gggattggct gctggtcagc      600

gtatccagca ctctcttcag cctctccagc ctgctgcgac cacagccgga gcctctgcgg      660

gagcctgtcg tcatcaccat ggcaacagtg gtgctgaccg tcctcaccca taaccctgcc      720

cctcgagtcc agctgggaaa ggatgcagtg ctggacctgc gcttcgccta cgcaccctcc      780

gccctggaag gttctccctc tctggacgca ggccctcctc cctttgggct ggagtggcga      840

cgccagcaca ggggaaaggg tcacctgctg ttggctgcca cccccgggct ggccgggaga      900

atgccaccag cccaggaaaa ggctacggca tttgcagctt gggatgacga tgagccctgg      960

ggcccgtgga ctgggaatgg gaccttctgg cttccagccg tgaagccttc tcaggagggt     1020

gtctacctgg ctacggtaca cctgccctac ctgcaaggac aggtctccct ggagctgact     1080

gtgcacaagg cccccagagt gtctctaaca ccagcacccg ttgtgtgggc tgccccagga     1140

gaggcacccc cagaactgct ctgtcttgca tcccacttct tccctgcgga gggtctggag     1200

gtcaagtggg agctcagagg cggcccagga ggaagttcta gaaaggttga ggggaagacg     1260

tggctctcca ccatccgcca ccattccgat ggctctgtca gccagtctgg gcacctgcag     1320

ctacctccag tcactgccaa gcagcatgga gttcactatg tctgtcgggt gtaccactct     1380

agcctgccag catcggggcg cagtgctgac gtcaccctgg aggtggcagg cttctcaggg     1440

ccctccatcg aggacggcat cggcctgttc ctgtctgctt ttctcctcct cggactcctc     1500

aaggtgctag gctggctggc tgcctactgg accattcctg aagtctcaaa ggagaaggcc     1560

acagctgcca gcctgaccat tcccaggaac tcaaagaagt cacagtaaag aagttctcgt     1620

ctgtggaagc caccctcatc tctggcccag atgactccag tagcccctgc cccagaacaa     1680

cagccttctt ctcttcttct ccctccattg aatagctcgg attttttttt ttaaggtttt     1740

tttgtttgtt tcaatctttc ttgttttgtt cttgttttta gacaaggtct ctctatgtag     1800

ccttggctgg ctgtcctgaa ccctcaccaa gccaaccagg ctggcctcga agtcccagag     1860

atccacctgt ccctctgcct cggagtgaca aacggcactg gacaccatgc ctagaggtct     1920

tttttttttt tggtttttgg agacaggatt tctctgtata gtcccggctg tcctggaact     1980

cactctgtag accaggctgg cctcgaactc agaaatccgc ctgcctctgc ctcccaggtg     2040

ctgggattaa aggcgtgcgc caccaccgct ggactcgaac taaactttta agatgagaaa     2100

aaagcgagac ttagcgccac actcatttga tgcccacagt cgggaggcag aggcagtgga     2160

tctctgacat ttccatgcca gcctgatcta caaataggga gtttcaggtc agtcggggtt     2220

acttggcggg gctttgttga gagaactaaa tataagaaca cacatgcgta gagtcccagg     2280

gttgagaaga accagtgtat gcgccagaga ggcgggttca taacctgtgg ctcacaaccc     2340

cctttaagtc catcggaaat accagacatt aggattcaca acagtagtaa aggcagttac     2400

gaagtagcaa agaaaataat tttacaactt gaactgcgtt aatgttaaga aggttgagaa     2460

ccactggcca ggggattagg acgaaaggtc ttcatagcat cttaagattc tagagacctc     2520

agggacagcc cacagcagta gtctagagac ggaaaggtcc atgtgtctcc ctcgcggact     2580

aaagcctacc tctccagctc tccattccta ccacagcttt tcttttgcct ggtccacctt     2640

taccatctcc gggcctggtg ggtctcggcc ctttacgaat gtccccgtgt ggttcgtcct     2700

ctcctgttcg ccggtcctcg tgagctaata aagtctttcc gagtttc                   2747


<210>  40
<211>  465
<212>  PRT
<213>  Mus musculus

<400>  40

Met Lys Pro Leu Leu Leu Leu Val Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Val Val Ser Val Val Ser Ala Gly Pro Glu Ala Ile Glu Cys Trp Phe 
            20                  25                  30          


Val Glu Asp Ala Gly Gly Gly Gly Leu Ser Lys Lys Pro Ala Thr Leu 
        35                  40                  45              


Leu Leu Arg His Gly Pro Arg Gly Pro Pro Pro Arg Pro Asp Leu Asp 
    50                  55                  60                  


Pro Lys Leu Tyr Phe Lys Val Asp Asp Pro Ala Gly Met Leu Leu Ala 
65                  70                  75                  80  


Ala Phe Arg Arg Tyr Pro Ala Gly Ala Ser Ala Pro His Cys Glu Met 
                85                  90                  95      


Ser Arg Phe Ile Pro Phe Pro Ala Ser Ala Lys Trp Ala Arg Ser Leu 
            100                 105                 110         


Ser Pro Glu Gln Asn Cys Pro Arg Ala Leu Asp Gly Asp Trp Leu Leu 
        115                 120                 125             


Val Ser Val Ser Ser Thr Leu Phe Ser Leu Ser Ser Leu Leu Arg Pro 
    130                 135                 140                 


Gln Pro Glu Pro Leu Arg Glu Pro Val Val Ile Thr Met Ala Thr Val 
145                 150                 155                 160 


Val Leu Thr Val Leu Thr His Asn Pro Ala Pro Arg Val Gln Leu Gly 
                165                 170                 175     


Lys Asp Ala Val Leu Asp Leu Arg Phe Ala Tyr Ala Pro Ser Ala Leu 
            180                 185                 190         


Glu Gly Ser Pro Ser Leu Asp Ala Gly Pro Pro Pro Phe Gly Leu Glu 
        195                 200                 205             


Trp Arg Arg Gln His Arg Gly Lys Gly His Leu Leu Leu Ala Ala Thr 
    210                 215                 220                 


Pro Gly Leu Ala Gly Arg Met Pro Pro Ala Gln Glu Lys Ala Thr Ala 
225                 230                 235                 240 


Phe Ala Ala Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn 
                245                 250                 255     


Gly Thr Phe Trp Leu Pro Ala Val Lys Pro Ser Gln Glu Gly Val Tyr 
            260                 265                 270         


Leu Ala Thr Val His Leu Pro Tyr Leu Gln Gly Gln Val Ser Leu Glu 
        275                 280                 285             


Leu Thr Val His Lys Ala Pro Arg Val Ser Leu Thr Pro Ala Pro Val 
    290                 295                 300                 


Val Trp Ala Ala Pro Gly Glu Ala Pro Pro Glu Leu Leu Cys Leu Ala 
305                 310                 315                 320 


Ser His Phe Phe Pro Ala Glu Gly Leu Glu Val Lys Trp Glu Leu Arg 
                325                 330                 335     


Gly Gly Pro Gly Gly Ser Ser Arg Lys Val Glu Gly Lys Thr Trp Leu 
            340                 345                 350         


Ser Thr Ile Arg His His Ser Asp Gly Ser Val Ser Gln Ser Gly His 
        355                 360                 365             


Leu Gln Leu Pro Pro Val Thr Ala Lys Gln His Gly Val His Tyr Val 
    370                 375                 380                 


Cys Arg Val Tyr His Ser Ser Leu Pro Ala Ser Gly Arg Ser Ala Asp 
385                 390                 395                 400 


Val Thr Leu Glu Val Ala Gly Phe Ser Gly Pro Ser Ile Glu Asp Gly 
                405                 410                 415     


Ile Gly Leu Phe Leu Ser Ala Phe Leu Leu Leu Gly Leu Leu Lys Val 
            420                 425                 430         


Leu Gly Trp Leu Ala Ala Tyr Trp Thr Ile Pro Glu Val Ser Lys Glu 
        435                 440                 445             


Lys Ala Thr Ala Ala Ser Leu Thr Ile Pro Arg Asn Ser Lys Lys Ser 
    450                 455                 460                 


Gln 
465 


<210>  41
<211>  5593
<212>  DNA
<213>  Homo sapiens

<400>  41
acggatccgc gttcagaaag gcgtgcactt cctacgcctg atcccccgca tcgcaacctc       60

gcagcttccc cggcgtgcag cgctcattta ccaattccct tcctgggagt tgcggcttcc      120

ctcgctcggc cccactcccg tttacccttt ccccagctcc cgccttagcc aggggcttcc      180

ccgcctgccg ctagggctcg ggccgaagcg ccgctcagcg ccagcctgcc gctccccggg      240

ctccactttc actttcggtc ctgggggagc taggccggcg gcagtggtgg tggcggcggc      300

gcaagggtga gggcggcccc agaaccccag gtaggtagag caagaagatg gtgtttctgc      360

ccctcaaatg gtcccttgca accatgtcat ttctactttc ctcactgttg gctctcttaa      420

ctgtgtccac tccttcatgg tgtcagagca ctgaagcatc tccaaaacgt agtgatggga      480

caccatttcc ttggaataaa atacgacttc ctgagtacgt catcccagtt cattatgatc      540

tcttgatcca tgcaaacctt accacgctga ccttctgggg aaccacgaaa gtagaaatca      600

cagccagtca gcccaccagc accatcatcc tgcatagtca ccacctgcag atatctaggg      660

ccaccctcag gaagggagct ggagagaggc tatcggaaga acccctgcag gtcctggaac      720

acccccgtca ggagcaaatt gcactgctgg ctcccgagcc cctccttgtc gggctcccgt      780

acacagttgt cattcactat gctggcaatc tttcggagac tttccacgga ttttacaaaa      840

gcacctacag aaccaaggaa ggggaactga ggatactagc atcaacacaa tttgaaccca      900

ctgcagctag aatggccttt ccctgctttg atgaacctgc cttcaaagca agtttctcaa      960

tcaaaattag aagagagcca aggcacctag ccatctccaa tatgccattg gtgaaatctg     1020

tgactgttgc tgaaggactc atagaagacc attttgatgt cactgtgaag atgagcacct     1080

atctggtggc cttcatcatt tcagattttg agtctgtcag caagataacc aagagtggag     1140

tcaaggtttc tgtttatgct gtgccagaca agataaatca agcagattat gcactggatg     1200

ctgcggtgac tcttctagaa ttttatgagg attatttcag cataccgtat cccctaccca     1260

aacaagatct tgctgctatt cccgactttc agtctggtgc tatggaaaac tggggactga     1320

caacatatag agaatctgct ctgttgtttg atgcagaaaa gtcttctgca tcaagtaagc     1380

ttggcatcac aatgactgtg gcccatgaac tggctcacca gtggtttggg aacctggtca     1440

ctatggaatg gtggaatgat ctttggctaa atgaaggatt tgccaaattt atggagtttg     1500

tgtctgtcag tgtgacccat cctgaactga aagttggaga ttatttcttt ggcaaatgtt     1560

ttgacgcaat ggaggtagat gctttaaatt cctcacaccc tgtgtctaca cctgtggaaa     1620

atcctgctca gatccgggag atgtttgatg atgtttctta tgataaggga gcttgtattc     1680

tgaatatgct aagggagtat cttagtgctg acgcatttaa aagtggtatt gtacagtatc     1740

tccagaagca tagctataaa aatacaaaaa acgaggacct gtgggatagt atggcaagta     1800

tttgccctac agatggtgta aaagggatgg atggcttttg ctctagaagt caacattcat     1860

cttcatcctc acattggcat caggaagggg tggatgtgaa aaccatgatg aacacttgga     1920

cactgcagaa gggttttccc ctaataacca tcacagtgag ggggaggaat gtacacatga     1980

agcaagagca ctacatgaag ggctctgacg gcgccccgga cactgggtac ctgtggcatg     2040

ttccattgac attcatcacc agcaaatccg acatggtcca tcgatttttg ctaaaaacaa     2100

aaacagatgt gctcatcctc ccagaagagg tggaatggat caaatttaat gtgggcatga     2160

atggctatta cattgtgcat tacgaggatg atggatggga ctctttgact ggccttttaa     2220

aaggaacaca cacagcagtc agcagtaatg atcgggcgag tctcattaac aatgcatttc     2280

agctcgtcag cattgggaag ctgtccattg aaaaggcctt ggatttatcc ctgtacttga     2340

aacatgaaac tgaaattatg cccgtgtttc aaggtttgaa tgagctgatt cctatgtata     2400

agttaatgga gaaaagagat atgaatgaag tggaaactca attcaaggcc ttcctcatca     2460

ggctgctaag ggacctcatt gataagcaga catggacaga cgagggctca gtctcagagc     2520

gaatgctgcg gagtcaacta ctactcctcg cctgtgtgca caactatcag ccgtgcgtac     2580

agagggcaga aggctatttc agaaagtgga aggaatccaa tggaaacttg agcctgcctg     2640

tcgacgtgac cttggcagtg tttgctgtgg gggcccagag cacagaaggc tgggattttc     2700

tttatagtaa atatcagttt tctttgtcca gtactgagaa aagccaaatt gaatttgccc     2760

tctgcagaac ccaaaataag gaaaagcttc aatggctact agatgaaagc tttaagggag     2820

ataaaataaa aactcaggag tttccacaaa ttcttacact cattggcagg aacccagtag     2880

gatacccact ggcctggcaa tttctgagga aaaactggaa caaacttgta caaaagtttg     2940

aacttggctc atcttccata gcccacatgg taatgggtac aacaaatcaa ttctccacaa     3000

gaacacggct tgaagaggta aaaggattct tcagctcttt gaaagaaaat ggttctcagc     3060

tccgttgtgt ccaacagaca attgaaacca ttgaagaaaa catcggttgg atggataaga     3120

attttgataa aatcagagtg tggctgcaaa gtgaaaagct tgaacatgat cctgaagctg     3180

acgcaacagg atgaaaatcc atcagaatct cagactacag cactaaatat gctttgatgc     3240

tacatcaaac ggaatggaag catagctgac ttcgctaaag ttacttcatc tccatctagc     3300

aaatgaggca ctgttctcaa ccaaaggaga tggggatctg gtttagggca atccctttat     3360

aatttgatgt gctgtggtct ccttggtaat gtataatttg gtattgcaca ggtgattagt     3420

caaggaagtc tggaaaagct ttggtcccac agccttgcct cacagcatgt aaataattaa     3480

aacaatattg atgctgaggt tcttctactg ctagtatgaa agtgacaaat ttttactggt     3540

gtgaattggg aagaaaacaa tgctattcca tgacgtttgt aaaatgtttg taaaagctca     3600

aacatgacga ttccataaaa taaacttgag gttaaataat gggtagtaaa ttatagaatg     3660

tataagaaaa aatataaagg agaaaatcaa ttatcaggaa agctaaagaa cttttcaaat     3720

ctagtaattt gaatatagac acaatgcact ttattgcact ttcaattctt ataaagcaac     3780

aataatatta aggtccttga ctatgtgtac aatgttttca catatatagt ttcatttaat     3840

catttcaaag ttaatctctg ccatctcgct aaatcatcag tctcggctct tctgaaatag     3900

aaggtgcctg atcttcctaa taattctgcc tattttcatt tgctttaaac aggcgcccta     3960

ttttctttct agttgtggct gcgcaaaaac atttatctcc caaataagat gtgctgctta     4020

ccgaggtatc acggggtggg gctccagctt gggtcgttga agctggggtt tgggaaacca     4080

cttcagagat ggcagcagca agtttagcat cttcaaattt cttttattga aaaaaatttt     4140

attagtaaca tgttgtatat aaaattatga gcacaatgcc atcacttaac tataactctt     4200

aaagatagct taatgactgt ttattctctt gaccaaatag actcataata acatataatt     4260

ttaaaagaaa tttaaattct ttcttctcta ttgtattatt ttatacaatt tgctatttct     4320

atttccttct catattgatt attctaaata ctatgcaata atataactta gagttccacg     4380

gtttgtttac acatttcctg ttgtacattt aggttattca aagttttcag ctcttttaaa     4440

attgctctga ataagttcta gtgagtgagt tatggtgctg gctatatttt gctaaactgc     4500

cctctcaaat gttgctagga attcatactg cgaaaagcaa tgaataagca tgcctgtttt     4560

cccatggcct tgcttgccag aatttgactt ttattatgat aatcagtgta aaatgatata     4620

ctactattgc ttgtatattg tggtatacgg tgtcaggttt cagggttttt tttcaacgtt     4680

aaatattcta gaaactttct gaaataattt ctgtttaaaa atattgaata tttgcttcat     4740

ttcaaatact cccttttgac aaaaaaactt aggtataact gttgatgaaa aaccagaaaa     4800

aagtccagaa ctctttggtg actccaacta tggatagctt attttgaaaa aggagaattg     4860

caaattttac caaaagatgg agaaaagcac attaaaaaga taccaacatt cagaaattca     4920

tttcagcatg ttattattgg aaattattta aactaattta gataactata agatacttat     4980

tgtccattta taccctgtaa agccgtttta gaatgtaata ttttaggtaa tccaaaatgt     5040

actaaattaa attcattttt agttatgaga aatctttgct tatatgacaa atgaaaagaa     5100

taacaagttg tcaaatgaaa agaatgacat tgaaacattt gtattgtctc ttcttaaact     5160

atcttattga cttattattt aagcctttta atactaagta tgaaacaacc tatggtctgg     5220

aaatttgtat cgcaaagcta tatgtgcata tgttatttaa ttcatctaat gctacacaaa     5280

agcataaaat aatgattttt cactctcttt aaaaatacta aatcatttat gtccatttct     5340

caattttttc attgatctat gctttgagtt tgctttctca acattattgt attttccact     5400

tattattact gtataacata tgctagtgtt tagttggatt aatcttacct aaaagtactg     5460

aaaaatgctt tttagtactt tttcatattt tatacattta ttttccgaat gtatcattga     5520

ataattttat tgagttataa aagtatctta ttgctattta ataaaaaatt aacacataaa     5580

atgaaaaaaa aaa                                                        5593


<210>  42
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Val Phe Leu Pro Leu Lys Trp Ser Leu Ala Thr Met Ser Phe Leu 
1               5                   10                  15      


Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr Pro Ser Trp Cys 
            20                  25                  30          


Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly Thr Pro Phe Pro 
        35                  40                  45              


Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro Val His Tyr Asp 
    50                  55                  60                  


Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe Trp Gly Thr Thr 
65                  70                  75                  80  


Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr Ile Ile Leu His 
                85                  90                  95      


Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg Lys Gly Ala Gly 
            100                 105                 110         


Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu His Pro Arg Gln 
        115                 120                 125             


Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Leu Val Gly Leu Pro 
    130                 135                 140                 


Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser Glu Thr Phe His 
145                 150                 155                 160 


Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly Glu Leu Arg Ile 
                165                 170                 175     


Leu Ala Ser Thr Gln Phe Glu Pro Thr Ala Ala Arg Met Ala Phe Pro 
            180                 185                 190         


Cys Phe Asp Glu Pro Ala Phe Lys Ala Ser Phe Ser Ile Lys Ile Arg 
        195                 200                 205             


Arg Glu Pro Arg His Leu Ala Ile Ser Asn Met Pro Leu Val Lys Ser 
    210                 215                 220                 


Val Thr Val Ala Glu Gly Leu Ile Glu Asp His Phe Asp Val Thr Val 
225                 230                 235                 240 


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Ile Ser Asp Phe Glu Ser 
                245                 250                 255     


Val Ser Lys Ile Thr Lys Ser Gly Val Lys Val Ser Val Tyr Ala Val 
            260                 265                 270         


Pro Asp Lys Ile Asn Gln Ala Asp Tyr Ala Leu Asp Ala Ala Val Thr 
        275                 280                 285             


Leu Leu Glu Phe Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr Pro Leu Pro 
    290                 295                 300                 


Lys Gln Asp Leu Ala Ala Ile Pro Asp Phe Gln Ser Gly Ala Met Glu 
305                 310                 315                 320 


Asn Trp Gly Leu Thr Thr Tyr Arg Glu Ser Ala Leu Leu Phe Asp Ala 
                325                 330                 335     


Glu Lys Ser Ser Ala Ser Ser Lys Leu Gly Ile Thr Met Thr Val Ala 
            340                 345                 350         


His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp 
        355                 360                 365             


Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Lys Phe Met Glu Phe 
    370                 375                 380                 


Val Ser Val Ser Val Thr His Pro Glu Leu Lys Val Gly Asp Tyr Phe 
385                 390                 395                 400 


Phe Gly Lys Cys Phe Asp Ala Met Glu Val Asp Ala Leu Asn Ser Ser 
                405                 410                 415     


His Pro Val Ser Thr Pro Val Glu Asn Pro Ala Gln Ile Arg Glu Met 
            420                 425                 430         


Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala Cys Ile Leu Asn Met Leu 
        435                 440                 445             


Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys Ser Gly Ile Val Gln Tyr 
    450                 455                 460                 


Leu Gln Lys His Ser Tyr Lys Asn Thr Lys Asn Glu Asp Leu Trp Asp 
465                 470                 475                 480 


Ser Met Ala Ser Ile Cys Pro Thr Asp Gly Val Lys Gly Met Asp Gly 
                485                 490                 495     


Phe Cys Ser Arg Ser Gln His Ser Ser Ser Ser Ser His Trp His Gln 
            500                 505                 510         


Glu Gly Val Asp Val Lys Thr Met Met Asn Thr Trp Thr Leu Gln Lys 
        515                 520                 525             


Gly Phe Pro Leu Ile Thr Ile Thr Val Arg Gly Arg Asn Val His Met 
    530                 535                 540                 


Lys Gln Glu His Tyr Met Lys Gly Ser Asp Gly Ala Pro Asp Thr Gly 
545                 550                 555                 560 


Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys Ser Asp Met 
                565                 570                 575     


Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu Ile Leu Pro 
            580                 585                 590         


Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn Gly Tyr Tyr 
        595                 600                 605             


Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr Gly Leu Leu 
    610                 615                 620                 


Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala Ser Leu Ile 
625                 630                 635                 640 


Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser Ile Glu Lys 
                645                 650                 655     


Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu Ile Met Pro 
            660                 665                 670         


Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys Leu Met Glu 
        675                 680                 685             


Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala Phe Leu Ile 
    690                 695                 700                 


Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr Asp Glu Gly 
705                 710                 715                 720 


Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu Leu Leu Leu Ala Cys 
                725                 730                 735     


Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly Tyr Phe Arg 
            740                 745                 750         


Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val Asp Val Thr 
        755                 760                 765             


Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly Trp Asp Phe 
    770                 775                 780                 


Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu Lys Ser Gln 
785                 790                 795                 800 


Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys Leu Gln Trp 
                805                 810                 815     


Leu Leu Asp Glu Ser Phe Lys Gly Asp Lys Ile Lys Thr Gln Glu Phe 
            820                 825                 830         


Pro Gln Ile Leu Thr Leu Ile Gly Arg Asn Pro Val Gly Tyr Pro Leu 
        835                 840                 845             


Ala Trp Gln Phe Leu Arg Lys Asn Trp Asn Lys Leu Val Gln Lys Phe 
    850                 855                 860                 


Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly Thr Thr Asn 
865                 870                 875                 880 


Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Val Lys Gly Phe Phe Ser 
                885                 890                 895     


Ser Leu Lys Glu Asn Gly Ser Gln Leu Arg Cys Val Gln Gln Thr Ile 
            900                 905                 910         


Glu Thr Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys 
        915                 920                 925             


Ile Arg Val Trp Leu Gln Ser Glu Lys Leu Glu His Asp Pro Glu Ala 
    930                 935                 940                 


Asp Ala Thr Gly 
945             


<210>  43
<211>  5589
<212>  DNA
<213>  Homo sapiens

<400>  43
acggatccgc gttcagaaag gcgtgcactt cctacgcctg atcccccgca tcgcaacctc       60

gcagcttccc cggcgtgcag cgctcattta ccaattccct tcctgggagt tgcggcttcc      120

ctcgctcggc cccactcccg tttacccttt ccccagctcc cgccttagcc aggggcttcc      180

ccgcctgccg ctagggctcg ggccgaagcg ccgctcagcg ccagcctgcc gctccccggg      240

ctccactttc actttcggtc ctgggggagc taggccggcg gcagtggtgg tggcggcggc      300

gcaagggtga gggcggcccc agaaccccag gtagagcaag aagatggtgt ttctgcccct      360

caaatggtcc cttgcaacca tgtcatttct actttcctca ctgttggctc tcttaactgt      420

gtccactcct tcatggtgtc agagcactga agcatctcca aaacgtagtg atgggacacc      480

atttccttgg aataaaatac gacttcctga gtacgtcatc ccagttcatt atgatctctt      540

gatccatgca aaccttacca cgctgacctt ctggggaacc acgaaagtag aaatcacagc      600

cagtcagccc accagcacca tcatcctgca tagtcaccac ctgcagatat ctagggccac      660

cctcaggaag ggagctggag agaggctatc ggaagaaccc ctgcaggtcc tggaacaccc      720

ccgtcaggag caaattgcac tgctggctcc cgagcccctc cttgtcgggc tcccgtacac      780

agttgtcatt cactatgctg gcaatctttc ggagactttc cacggatttt acaaaagcac      840

ctacagaacc aaggaagggg aactgaggat actagcatca acacaatttg aacccactgc      900

agctagaatg gcctttccct gctttgatga acctgccttc aaagcaagtt tctcaatcaa      960

aattagaaga gagccaaggc acctagccat ctccaatatg ccattggtga aatctgtgac     1020

tgttgctgaa ggactcatag aagaccattt tgatgtcact gtgaagatga gcacctatct     1080

ggtggccttc atcatttcag attttgagtc tgtcagcaag ataaccaaga gtggagtcaa     1140

ggtttctgtt tatgctgtgc cagacaagat aaatcaagca gattatgcac tggatgctgc     1200

ggtgactctt ctagaatttt atgaggatta tttcagcata ccgtatcccc tacccaaaca     1260

agatcttgct gctattcccg actttcagtc tggtgctatg gaaaactggg gactgacaac     1320

atatagagaa tctgctctgt tgtttgatgc agaaaagtct tctgcatcaa gtaagcttgg     1380

catcacaatg actgtggccc atgaactggc tcaccagtgg tttgggaacc tggtcactat     1440

ggaatggtgg aatgatcttt ggctaaatga aggatttgcc aaatttatgg agtttgtgtc     1500

tgtcagtgtg acccatcctg aactgaaagt tggagattat ttctttggca aatgttttga     1560

cgcaatggag gtagatgctt taaattcctc acaccctgtg tctacacctg tggaaaatcc     1620

tgctcagatc cgggagatgt ttgatgatgt ttcttatgat aagggagctt gtattctgaa     1680

tatgctaagg gagtatctta gtgctgacgc atttaaaagt ggtattgtac agtatctcca     1740

gaagcatagc tataaaaata caaaaaacga ggacctgtgg gatagtatgg caagtatttg     1800

ccctacagat ggtgtaaaag ggatggatgg cttttgctct agaagtcaac attcatcttc     1860

atcctcacat tggcatcagg aaggggtgga tgtgaaaacc atgatgaaca cttggacact     1920

gcagaagggt tttcccctaa taaccatcac agtgaggggg aggaatgtac acatgaagca     1980

agagcactac atgaagggct ctgacggcgc cccggacact gggtacctgt ggcatgttcc     2040

attgacattc atcaccagca aatccgacat ggtccatcga tttttgctaa aaacaaaaac     2100

agatgtgctc atcctcccag aagaggtgga atggatcaaa tttaatgtgg gcatgaatgg     2160

ctattacatt gtgcattacg aggatgatgg atgggactct ttgactggcc ttttaaaagg     2220

aacacacaca gcagtcagca gtaatgatcg ggcgagtctc attaacaatg catttcagct     2280

cgtcagcatt gggaagctgt ccattgaaaa ggccttggat ttatccctgt acttgaaaca     2340

tgaaactgaa attatgcccg tgtttcaagg tttgaatgag ctgattccta tgtataagtt     2400

aatggagaaa agagatatga atgaagtgga aactcaattc aaggccttcc tcatcaggct     2460

gctaagggac ctcattgata agcagacatg gacagacgag ggctcagtct cagagcgaat     2520

gctgcggagt caactactac tcctcgcctg tgtgcacaac tatcagccgt gcgtacagag     2580

ggcagaaggc tatttcagaa agtggaagga atccaatgga aacttgagcc tgcctgtcga     2640

cgtgaccttg gcagtgtttg ctgtgggggc ccagagcaca gaaggctggg attttcttta     2700

tagtaaatat cagttttctt tgtccagtac tgagaaaagc caaattgaat ttgccctctg     2760

cagaacccaa aataaggaaa agcttcaatg gctactagat gaaagcttta agggagataa     2820

aataaaaact caggagtttc cacaaattct tacactcatt ggcaggaacc cagtaggata     2880

cccactggcc tggcaatttc tgaggaaaaa ctggaacaaa cttgtacaaa agtttgaact     2940

tggctcatct tccatagccc acatggtaat gggtacaaca aatcaattct ccacaagaac     3000

acggcttgaa gaggtaaaag gattcttcag ctctttgaaa gaaaatggtt ctcagctccg     3060

ttgtgtccaa cagacaattg aaaccattga agaaaacatc ggttggatgg ataagaattt     3120

tgataaaatc agagtgtggc tgcaaagtga aaagcttgaa catgatcctg aagctgacgc     3180

aacaggatga aaatccatca gaatctcaga ctacagcact aaatatgctt tgatgctaca     3240

tcaaacggaa tggaagcata gctgacttcg ctaaagttac ttcatctcca tctagcaaat     3300

gaggcactgt tctcaaccaa aggagatggg gatctggttt agggcaatcc ctttataatt     3360

tgatgtgctg tggtctcctt ggtaatgtat aatttggtat tgcacaggtg attagtcaag     3420

gaagtctgga aaagctttgg tcccacagcc ttgcctcaca gcatgtaaat aattaaaaca     3480

atattgatgc tgaggttctt ctactgctag tatgaaagtg acaaattttt actggtgtga     3540

attgggaaga aaacaatgct attccatgac gtttgtaaaa tgtttgtaaa agctcaaaca     3600

tgacgattcc ataaaataaa cttgaggtta aataatgggt agtaaattat agaatgtata     3660

agaaaaaata taaaggagaa aatcaattat caggaaagct aaagaacttt tcaaatctag     3720

taatttgaat atagacacaa tgcactttat tgcactttca attcttataa agcaacaata     3780

atattaaggt ccttgactat gtgtacaatg ttttcacata tatagtttca tttaatcatt     3840

tcaaagttaa tctctgccat ctcgctaaat catcagtctc ggctcttctg aaatagaagg     3900

tgcctgatct tcctaataat tctgcctatt ttcatttgct ttaaacaggc gccctatttt     3960

ctttctagtt gtggctgcgc aaaaacattt atctcccaaa taagatgtgc tgcttaccga     4020

ggtatcacgg ggtggggctc cagcttgggt cgttgaagct ggggtttggg aaaccacttc     4080

agagatggca gcagcaagtt tagcatcttc aaatttcttt tattgaaaaa aattttatta     4140

gtaacatgtt gtatataaaa ttatgagcac aatgccatca cttaactata actcttaaag     4200

atagcttaat gactgtttat tctcttgacc aaatagactc ataataacat ataattttaa     4260

aagaaattta aattctttct tctctattgt attattttat acaatttgct atttctattt     4320

ccttctcata ttgattattc taaatactat gcaataatat aacttagagt tccacggttt     4380

gtttacacat ttcctgttgt acatttaggt tattcaaagt tttcagctct tttaaaattg     4440

ctctgaataa gttctagtga gtgagttatg gtgctggcta tattttgcta aactgccctc     4500

tcaaatgttg ctaggaattc atactgcgaa aagcaatgaa taagcatgcc tgttttccca     4560

tggccttgct tgccagaatt tgacttttat tatgataatc agtgtaaaat gatatactac     4620

tattgcttgt atattgtggt atacggtgtc aggtttcagg gttttttttc aacgttaaat     4680

attctagaaa ctttctgaaa taatttctgt ttaaaaatat tgaatatttg cttcatttca     4740

aatactccct tttgacaaaa aaacttaggt ataactgttg atgaaaaacc agaaaaaagt     4800

ccagaactct ttggtgactc caactatgga tagcttattt tgaaaaagga gaattgcaaa     4860

ttttaccaaa agatggagaa aagcacatta aaaagatacc aacattcaga aattcatttc     4920

agcatgttat tattggaaat tatttaaact aatttagata actataagat acttattgtc     4980

catttatacc ctgtaaagcc gttttagaat gtaatatttt aggtaatcca aaatgtacta     5040

aattaaattc atttttagtt atgagaaatc tttgcttata tgacaaatga aaagaataac     5100

aagttgtcaa atgaaaagaa tgacattgaa acatttgtat tgtctcttct taaactatct     5160

tattgactta ttatttaagc cttttaatac taagtatgaa acaacctatg gtctggaaat     5220

ttgtatcgca aagctatatg tgcatatgtt atttaattca tctaatgcta cacaaaagca     5280

taaaataatg atttttcact ctctttaaaa atactaaatc atttatgtcc atttctcaat     5340

tttttcattg atctatgctt tgagtttgct ttctcaacat tattgtattt tccacttatt     5400

attactgtat aacatatgct agtgtttagt tggattaatc ttacctaaaa gtactgaaaa     5460

atgcttttta gtactttttc atattttata catttatttt ccgaatgtat cattgaataa     5520

ttttattgag ttataaaagt atcttattgc tatttaataa aaaattaaca cataaaatga     5580

aaaaaaaaa                                                             5589


<210>  44
<211>  5110
<212>  DNA
<213>  Homo sapiens

<400>  44
acggatccgc gttcagaaag gcgtgcactt cctacgcctg atcccccgca tcgcaacctc       60

gcagcttccc cggcgtgcag cgctcattta ccaattccct tcctgggagt tgcggcttcc      120

ctcgctcggc cccactcccg tttacccttt ccccagctcc cgccttagcc aggggcttcc      180

ccgcctgccg ctagggctcg ggccgaagcg ccgctcagcg ccagcctgcc gctccccggg      240

ctccactttc actttcggtc ctgggggagc taggccggcg gcagtggtgg tggcggcggc      300

gcaagggtga gggcggcccc agaaccccag gtaggtagag caagaagatg gtgtttctgc      360

ccctcaaatg gtcccttgca accatgtcat ttctactttc ctcactgttg gctctcttaa      420

ctgtgtccac tccttcatgg tgtcagagca ctgaagcatc tccaaaacgt agtgatggga      480

caccatttcc ttggaataaa atacgacttc ctgagtacgt catcccagtt cattatgatc      540

tcttgatcca tgcaaacctt accacgctga ccttctgggg aaccacgaaa gtagaaatca      600

cagccagtca gcccaccagc accatcatcc tgcatagtca ccacctgcag atatctaggg      660

ccaccctcag gaagggagct ggagagaggc tatcggaaga acccctgcag gtcctggaac      720

acccccgtca ggagcaaatt gcactgctgg ctcccgagcc cctccttgtc gggctcccgt      780

acacagttgt cattcactat gctggcaatc tttcggagac tttccacgga ttttacaaaa      840

gcacctacag aaccaaggaa ggggaactga ggatactagc atcaacacaa tttgaaccca      900

ctgcagctag aatggccttt ccctgctttg atgaacctgc cttcaaagca agtttctcaa      960

tcaaaattag aagagagcca aggcacctag ccatctccaa tatgccattg gtgaaatctg     1020

tgactgttgc tgaaggactc atagaagacc attttgatgt cactgtgaag atgagcacct     1080

atctggtggc cttcatcatt tcagattttg agtctgtcag caagataacc aagagtggag     1140

tcaaggtttc tgtttatgct gtgccagaca agataaatca agcagattat gcactggatg     1200

ctgcggtgac tcttctagaa ttttatgagg attatttcag cataccgtat cccctaccca     1260

aacaagatct tgctgctatt cccgactttc agtctggtgc tatggaaaac tggggactga     1320

caacatatag agaatctgct ctgttgtttg atgcagaaaa gtcttctgca tcaagtaagc     1380

ttggcatcac aatgactgtg gcccatgaac tggctcacca gtggtttggg aacctggtca     1440

ctatggaatg gtggaatgat ctttggctaa atgaaggatt tgccaaattt atggagtttg     1500

tgtctgtcag tgtgacccat cctgaactga aagttggaga ttatttcttt ggcaaatgtt     1560

ttgacgcaat ggaggtagat gctttaaatt cctcacaccc tgtgtctaca cctgtggaaa     1620

atcctgctca gatccgggag atgtttgatg atgtttctta tgataaggga gcttgtattc     1680

tgaatatgct aagggagtat cttagtgctg acgcatttaa aagtggtatt gtacagtatc     1740

tccagaagca tagctataaa aatacaaaaa acgaggacct gtgggatagt atggcaagta     1800

tttgccctac agatggtgta aaagggatgg atggcttttg ctctagaagt caacattcat     1860

cttcatcctc acattggcat caggaagggg tggatgtgaa aaccatgatg aacacttgga     1920

cactgcagaa gggttttccc ctaataacca tcacagtgag ggggaggaat gtacacatga     1980

agcaagagca ctacatgaag ggctctgacg gcgccccgga cactgggtac ctgtggcatg     2040

ttccattgac attcatcacc agcaaatccg acatggtcca tcgatttttg ctaaaaacaa     2100

aaacagatgt gctcatcctc ccagaagagg tggaatggat caaatttaat gtgggcatga     2160

atggctatta cattgtgcat tacgaggatg atggatggga ctctttgact ggccttttaa     2220

aaggaacaca cacagcagtc agcagtaatg atcgggcgag tctcattaac aatgcatttc     2280

agctcgtcag cattgggaag ctgtccattg aaaaggcctt ggatttatcc ctgtacttga     2340

aacatgaaac tgaaattatg cccgtgtttc aaggtttgaa tgagctgatt cctatgtata     2400

agttaatgga gaaaagagat atgaatgaag tggaaactca attcaaggcc ttcctcatca     2460

ggctgctaag ggacctcatt gataagcaga catggacaga cgagggctca gtctcagagc     2520

gaatgctgcg gagtcaacta ctactcctcg cctgtgtgca caactatcag ccgtgcgtac     2580

agagggcaga aggctatttc agaaagtgga aggaatccaa tggaaacttg agcctgcctg     2640

tcgacgtgac cttggcagtg tttgctgtgg gggcccagag cacagaaggc tgggattttc     2700

tttatagtaa atatcagttt tctttgtcca gtactgagaa aagccaaatt gaatttgccc     2760

tctgcagaac ccaaaataag gaaaagcttc aatggctact agatgaaagc tttaagggag     2820

ataaaataaa aactcaggag tttccacaaa ttcttacact cattggcagg aacccagtag     2880

gatacccact ggcctggcaa tttctgagga aaaactggaa caaacttgta caaaagtttg     2940

aacttggctc atcttccata gcccacatgg taatgggtac aacaaatcaa ttctccacaa     3000

gaacacggct tgaagaggta aaaggattct tcagctcttt gaaagaaaat ggttctcagc     3060

tccgttgtgt ccaacagaca attgaaacca ttgaagaaaa catcggttgg atggataaga     3120

attttgataa aatcagagtg tggctgcaaa gtgaaaagct tgaacgtatg taaaaattcc     3180

tcccttgcca ggttcctgtt atctctaatc accaacattt tgttgagtgt attttcaaac     3240

tagagatggc tgttttggct ccaactggag atactttttt cccttcaact cattttttga     3300

ctatccctgt gaaaagaata gctgttagtt tttcatgaat gggctatcgc taccatgtgt     3360

tttgttcatc acaggtgttg ccctgcaacg taaacccaag tgttgggttc cctgccacag     3420

aagaataaag taccttattc ttctcatttt atagtttatg cttaagcacc cgtgtccaaa     3480

accctgtacc ccatgtttat cattcataaa ctgtttcatc agtctcctcg aaagactctg     3540

aatagtcgac tactgaacaa tgaacacctg gatctgagac taagccggac gatgactggg     3600

ttaaagctct cccggctcac ccctccagac ccgctgccca tccctcttcc ttgctccatg     3660

cccaggggct gacttgtaaa ggccaagtca tcaagctttc ttgccctttg gatgttggtc     3720

agtggggagc cggagagctg gagctggggt cggaggaggt agtaggtgga ggtgttcttc     3780

cctgattccc ttgcgggatg cctcgggctg gcctcccctg agggtcttag ctccgagagg     3840

ggaccctctt ttccacacag ccttctccac ctctggattt tggtaactgc tccctcctca     3900

tcccttcagg attagtggcc tcagtgggag tctggctttt actagtcctg gcggacttgt     3960

ggtttctaca taatgtgctc gcacttttgc aaaaaatctt tttatagaac cctcctcaga     4020

taattctgag tgagtgtcat ctatttccct gactggtaca gtatctcttc tgaaaaagca     4080

gagtgcattc aagtctgtag gaaaaccctt ttcttaggga ggtgattttt tttctctctc     4140

tgcttcttat ttggcctact ttacaatttc taactaacta gttattggca tttactgaca     4200

gtaaattatt gcagtcacca ataaatgata gtacattgtg aaacaaaata tttgctcata     4260

ttagcaaata ggacattctt tggctttgaa gtctttcttt cttttgtgaa gacttcacac     4320

acggttgctt cagcacacag ttgctgctca ggttttatgt atagatgata ataatagaaa     4380

gcacagttta ctaacatggt aaaccaacgg agttcaagtc aagtcagtta ataccctaag     4440

aattagattt tatttcttat tctgaaaact tgctacacag ggacttatct aacccatagt     4500

gtgctctgtt gctgacttga ttcaagttgc agcgtgtttt gcgctgactc taaggtgcgg     4560

aaatcctcac acctggcaaa ggagaattca aactgaactt tttgaatata aggcaaaaac     4620

ttcaagataa gggaatatga ttgatgattg gtacgaaaaa tgtcaaaatg tgttccccta     4680

atacacgaca aaatagagtg acttctggac ataaatctgc catttattaa accattcact     4740

acaacaaata aataggtata aaagtggaat tggaattttt atacttattt gttgtagtga     4800

atggtttaat aaaaatagaa atcactggta atttccaccc caaactaaac tatttccctt     4860

cttttaaaaa aatacacaac caagatttta atgtaaaata ttttgcttta attgtatttt     4920

atgccttgat taatgaaaca tggaaatatt gattttcagt tttggtcacc tgaggaacct     4980

atctttgttt gcttttggaa aagcccattt tctaaacaga tacaatattg ccacaacaat     5040

gtgcagaaac ctttttgata ataaaaaatt gttctttgcc tctaaaaaaa aaaaaaaaaa     5100

aaaaaaaaaa                                                            5110


<210>  45
<211>  941
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Val Phe Leu Pro Leu Lys Trp Ser Leu Ala Thr Met Ser Phe Leu 
1               5                   10                  15      


Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr Pro Ser Trp Cys 
            20                  25                  30          


Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly Thr Pro Phe Pro 
        35                  40                  45              


Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro Val His Tyr Asp 
    50                  55                  60                  


Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe Trp Gly Thr Thr 
65                  70                  75                  80  


Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr Ile Ile Leu His 
                85                  90                  95      


Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg Lys Gly Ala Gly 
            100                 105                 110         


Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu His Pro Arg Gln 
        115                 120                 125             


Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Leu Val Gly Leu Pro 
    130                 135                 140                 


Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser Glu Thr Phe His 
145                 150                 155                 160 


Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly Glu Leu Arg Ile 
                165                 170                 175     


Leu Ala Ser Thr Gln Phe Glu Pro Thr Ala Ala Arg Met Ala Phe Pro 
            180                 185                 190         


Cys Phe Asp Glu Pro Ala Phe Lys Ala Ser Phe Ser Ile Lys Ile Arg 
        195                 200                 205             


Arg Glu Pro Arg His Leu Ala Ile Ser Asn Met Pro Leu Val Lys Ser 
    210                 215                 220                 


Val Thr Val Ala Glu Gly Leu Ile Glu Asp His Phe Asp Val Thr Val 
225                 230                 235                 240 


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Ile Ser Asp Phe Glu Ser 
                245                 250                 255     


Val Ser Lys Ile Thr Lys Ser Gly Val Lys Val Ser Val Tyr Ala Val 
            260                 265                 270         


Pro Asp Lys Ile Asn Gln Ala Asp Tyr Ala Leu Asp Ala Ala Val Thr 
        275                 280                 285             


Leu Leu Glu Phe Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr Pro Leu Pro 
    290                 295                 300                 


Lys Gln Asp Leu Ala Ala Ile Pro Asp Phe Gln Ser Gly Ala Met Glu 
305                 310                 315                 320 


Asn Trp Gly Leu Thr Thr Tyr Arg Glu Ser Ala Leu Leu Phe Asp Ala 
                325                 330                 335     


Glu Lys Ser Ser Ala Ser Ser Lys Leu Gly Ile Thr Met Thr Val Ala 
            340                 345                 350         


His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp 
        355                 360                 365             


Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Lys Phe Met Glu Phe 
    370                 375                 380                 


Val Ser Val Ser Val Thr His Pro Glu Leu Lys Val Gly Asp Tyr Phe 
385                 390                 395                 400 


Phe Gly Lys Cys Phe Asp Ala Met Glu Val Asp Ala Leu Asn Ser Ser 
                405                 410                 415     


His Pro Val Ser Thr Pro Val Glu Asn Pro Ala Gln Ile Arg Glu Met 
            420                 425                 430         


Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala Cys Ile Leu Asn Met Leu 
        435                 440                 445             


Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys Ser Gly Ile Val Gln Tyr 
    450                 455                 460                 


Leu Gln Lys His Ser Tyr Lys Asn Thr Lys Asn Glu Asp Leu Trp Asp 
465                 470                 475                 480 


Ser Met Ala Ser Ile Cys Pro Thr Asp Gly Val Lys Gly Met Asp Gly 
                485                 490                 495     


Phe Cys Ser Arg Ser Gln His Ser Ser Ser Ser Ser His Trp His Gln 
            500                 505                 510         


Glu Gly Val Asp Val Lys Thr Met Met Asn Thr Trp Thr Leu Gln Lys 
        515                 520                 525             


Gly Phe Pro Leu Ile Thr Ile Thr Val Arg Gly Arg Asn Val His Met 
    530                 535                 540                 


Lys Gln Glu His Tyr Met Lys Gly Ser Asp Gly Ala Pro Asp Thr Gly 
545                 550                 555                 560 


Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys Ser Asp Met 
                565                 570                 575     


Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu Ile Leu Pro 
            580                 585                 590         


Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn Gly Tyr Tyr 
        595                 600                 605             


Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr Gly Leu Leu 
    610                 615                 620                 


Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala Ser Leu Ile 
625                 630                 635                 640 


Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser Ile Glu Lys 
                645                 650                 655     


Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu Ile Met Pro 
            660                 665                 670         


Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys Leu Met Glu 
        675                 680                 685             


Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala Phe Leu Ile 
    690                 695                 700                 


Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr Asp Glu Gly 
705                 710                 715                 720 


Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu Leu Leu Leu Ala Cys 
                725                 730                 735     


Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly Tyr Phe Arg 
            740                 745                 750         


Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val Asp Val Thr 
        755                 760                 765             


Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly Trp Asp Phe 
    770                 775                 780                 


Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu Lys Ser Gln 
785                 790                 795                 800 


Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys Leu Gln Trp 
                805                 810                 815     


Leu Leu Asp Glu Ser Phe Lys Gly Asp Lys Ile Lys Thr Gln Glu Phe 
            820                 825                 830         


Pro Gln Ile Leu Thr Leu Ile Gly Arg Asn Pro Val Gly Tyr Pro Leu 
        835                 840                 845             


Ala Trp Gln Phe Leu Arg Lys Asn Trp Asn Lys Leu Val Gln Lys Phe 
    850                 855                 860                 


Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly Thr Thr Asn 
865                 870                 875                 880 


Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Val Lys Gly Phe Phe Ser 
                885                 890                 895     


Ser Leu Lys Glu Asn Gly Ser Gln Leu Arg Cys Val Gln Gln Thr Ile 
            900                 905                 910         


Glu Thr Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys 
        915                 920                 925             


Ile Arg Val Trp Leu Gln Ser Glu Lys Leu Glu Arg Met 
    930                 935                 940     


<210>  46
<211>  4868
<212>  DNA
<213>  Homo sapiens

<400>  46
ccttcccttc tgctgggcct caggtgagac tgcagctcca gtcatcatct tgattgcagc       60

ccacagaaac taccaaccca cagaaactgt aggtagagca agaagatggt gtttctgccc      120

ctcaaatggt cccttgcaac catgtcattt ctactttcct cactgttggc tctcttaact      180

gtgtccactc cttcatggtg tcagagcact gaagcatctc caaaacgtag tgatgggaca      240

ccatttcctt ggaataaaat acgacttcct gagtacgtca tcccagttca ttatgatctc      300

ttgatccatg caaaccttac cacgctgacc ttctggggaa ccacgaaagt agaaatcaca      360

gccagtcagc ccaccagcac catcatcctg catagtcacc acctgcagat atctagggcc      420

accctcagga agggagctgg agagaggcta tcggaagaac ccctgcaggt cctggaacac      480

ccccgtcagg agcaaattgc actgctggct cccgagcccc tccttgtcgg gctcccgtac      540

acagttgtca ttcactatgc tggcaatctt tcggagactt tccacggatt ttacaaaagc      600

acctacagaa ccaaggaagg ggaactgagg atactagcat caacacaatt tgaacccact      660

gcagctagaa tggcctttcc ctgctttgat gaacctgcct tcaaagcaag tttctcaatc      720

aaaattagaa gagagccaag gcacctagcc atctccaata tgccattggt gaaatctgtg      780

actgttgctg aaggactcat agaagaccat tttgatgtca ctgtgaagat gagcacctat      840

ctggtggcct tcatcatttc agattttgag tctgtcagca agataaccaa gagtggagtc      900

aaggtttctg tttatgctgt gccagacaag ataaatcaag cagattatgc actggatgct      960

gcggtgactc ttctagaatt ttatgaggat tatttcagca taccgtatcc cctacccaaa     1020

caagatcttg ctgctattcc cgactttcag tctggtgcta tggaaaactg gggactgaca     1080

acatatagag aatctgctct gttgtttgat gcagaaaagt cttctgcatc aagtaagctt     1140

ggcatcacaa tgactgtggc ccatgaactg gctcaccagt ggtttgggaa cctggtcact     1200

atggaatggt ggaatgatct ttggctaaat gaaggatttg ccaaatttat ggagtttgtg     1260

tctgtcagtg tgacccatcc tgaactgaaa gttggagatt atttctttgg caaatgtttt     1320

gacgcaatgg aggtagatgc tttaaattcc tcacaccctg tgtctacacc tgtggaaaat     1380

cctgctcaga tccgggagat gtttgatgat gtttcttatg ataagggagc ttgtattctg     1440

aatatgctaa gggagtatct tagtgctgac gcatttaaaa gtggtattgt acagtatctc     1500

cagaagcata gctataaaaa tacaaaaaac gaggacctgt gggatagtat ggcaagtatt     1560

tgccctacag atggtgtaaa agggatggat ggcttttgct ctagaagtca acattcatct     1620

tcatcctcac attggcatca ggaaggggtg gatgtgaaaa ccatgatgaa cacttggaca     1680

ctgcagaagg gttttcccct aataaccatc acagtgaggg ggaggaatgt acacatgaag     1740

caagagcact acatgaaggg ctctgacggc gccccggaca ctgggtacct gtggcatgtt     1800

ccattgacat tcatcaccag caaatccgac atggtccatc gatttttgct aaaaacaaaa     1860

acagatgtgc tcatcctccc agaagaggtg gaatggatca aatttaatgt gggcatgaat     1920

ggctattaca ttgtgcatta cgaggatgat ggatgggact ctttgactgg ccttttaaaa     1980

ggaacacaca cagcagtcag cagtaatgat cgggcgagtc tcattaacaa tgcatttcag     2040

ctcgtcagca ttgggaagct gtccattgaa aaggccttgg atttatccct gtacttgaaa     2100

catgaaactg aaattatgcc cgtgtttcaa ggtttgaatg agctgattcc tatgtataag     2160

ttaatggaga aaagagatat gaatgaagtg gaaactcaat tcaaggcctt cctcatcagg     2220

ctgctaaggg acctcattga taagcagaca tggacagacg agggctcagt ctcagagcga     2280

atgctgcgga gtcaactact actcctcgcc tgtgtgcaca actatcagcc gtgcgtacag     2340

agggcagaag gctatttcag aaagtggaag gaatccaatg gaaacttgag cctgcctgtc     2400

gacgtgacct tggcagtgtt tgctgtgggg gcccagagca cagaaggctg ggattttctt     2460

tatagtaaat atcagttttc tttgtccagt actgagaaaa gccaaattga atttgccctc     2520

tgcagaaccc aaaataagga aaagcttcaa tggctactag atgaaagctt taagggagat     2580

aaaataaaaa ctcaggagtt tccacaaatt cttacactca ttggcaggaa cccagtagga     2640

tacccactgg cctggcaatt tctgaggaaa aactggaaca aacttgtaca aaagtttgaa     2700

cttggctcat cttccatagc ccacatggta atgggtacaa caaatcaatt ctccacaaga     2760

acacggcttg aagaggtaaa aggattcttc agctctttga aagaaaatgg ttctcagctc     2820

cgttgtgtcc aacagacaat tgaaaccatt gaagaaaaca tcggttggat ggataagaat     2880

tttgataaaa tcagagtgtg gctgcaaagt gaaaagcttg aacgtatgta aaaattcctc     2940

ccttgccagg ttcctgttat ctctaatcac caacattttg ttgagtgtat tttcaaacta     3000

gagatggctg ttttggctcc aactggagat acttttttcc cttcaactca ttttttgact     3060

atccctgtga aaagaatagc tgttagtttt tcatgaatgg gctatcgcta ccatgtgttt     3120

tgttcatcac aggtgttgcc ctgcaacgta aacccaagtg ttgggttccc tgccacagaa     3180

gaataaagta ccttattctt ctcattttat agtttatgct taagcacccg tgtccaaaac     3240

cctgtacccc atgtttatca ttcataaact gtttcatcag tctcctcgaa agactctgaa     3300

tagtcgacta ctgaacaatg aacacctgga tctgagacta agccggacga tgactgggtt     3360

aaagctctcc cggctcaccc ctccagaccc gctgcccatc cctcttcctt gctccatgcc     3420

caggggctga cttgtaaagg ccaagtcatc aagctttctt gccctttgga tgttggtcag     3480

tggggagccg gagagctgga gctggggtcg gaggaggtag taggtggagg tgttcttccc     3540

tgattccctt gcgggatgcc tcgggctggc ctcccctgag ggtcttagct ccgagagggg     3600

accctctttt ccacacagcc ttctccacct ctggattttg gtaactgctc cctcctcatc     3660

ccttcaggat tagtggcctc agtgggagtc tggcttttac tagtcctggc ggacttgtgg     3720

tttctacata atgtgctcgc acttttgcaa aaaatctttt tatagaaccc tcctcagata     3780

attctgagtg agtgtcatct atttccctga ctggtacagt atctcttctg aaaaagcaga     3840

gtgcattcaa gtctgtagga aaaccctttt cttagggagg tgattttttt tctctctctg     3900

cttcttattt ggcctacttt acaatttcta actaactagt tattggcatt tactgacagt     3960

aaattattgc agtcaccaat aaatgatagt acattgtgaa acaaaatatt tgctcatatt     4020

agcaaatagg acattctttg gctttgaagt ctttctttct tttgtgaaga cttcacacac     4080

ggttgcttca gcacacagtt gctgctcagg ttttatgtat agatgataat aatagaaagc     4140

acagtttact aacatggtaa accaacggag ttcaagtcaa gtcagttaat accctaagaa     4200

ttagatttta tttcttattc tgaaaacttg ctacacaggg acttatctaa cccatagtgt     4260

gctctgttgc tgacttgatt caagttgcag cgtgttttgc gctgactcta aggtgcggaa     4320

atcctcacac ctggcaaagg agaattcaaa ctgaactttt tgaatataag gcaaaaactt     4380

caagataagg gaatatgatt gatgattggt acgaaaaatg tcaaaatgtg ttcccctaat     4440

acacgacaaa atagagtgac ttctggacat aaatctgcca tttattaaac cattcactac     4500

aacaaataaa taggtataaa agtggaattg gaatttttat acttatttgt tgtagtgaat     4560

ggtttaataa aaatagaaat cactggtaat ttccacccca aactaaacta tttcccttct     4620

tttaaaaaaa tacacaacca agattttaat gtaaaatatt ttgctttaat tgtattttat     4680

gccttgatta atgaaacatg gaaatattga ttttcagttt tggtcacctg aggaacctat     4740

ctttgtttgc ttttggaaaa gcccattttc taaacagata caatattgcc acaacaatgt     4800

gcagaaacct ttttgataat aaaaaattgt tctttgcctc taaaaaaaaa aaaaaaaaaa     4860

aaaaaaaa                                                              4868


<210>  47
<211>  4014
<212>  DNA
<213>  Mus musculus

<400>  47
cagactggcg gctgtgatga aggtaatttg agcaagaaga tagtgtctct gctcctcaaa       60

tagccacttg caagcatgcc ctctcttctt cccctagtat tgacattttt atctgtgtca      120

tctccttctt ggtgtcagaa cagtgatata gaatctctaa aagctagtaa tggagactca      180

ttcccttgga ataatatgcg acttcctgag tatatgaccc cgattcatta tgatctcatg      240

atccatgcaa acctcagcac tctgactttc tggggaaaaa cagaagtaga aatcatagct      300

agccggccca ccagcaccat tattatgcat agtcaccacc tgcaaatatc taaggccacc      360

ctcagaagag gagctggaga gatgctgtct gaagaaccac tgaaggtcct ggaatatcct      420

gctcatgagc aagttgcact gctggctgcc cagccgcttc ttgctgggtc cctgtacaca      480

gttatcatcg actatgctgc caacctgtct gagagtttcc atggattcta taagagcacc      540

tacagaacac aggaaggtga aatgagaata cttgcagcaa cacagtttga acccacagct      600

gctagaatgg cttttccctg ctttgatgaa cctgccctca aggcaagttt ttccatcaag      660

ataaagaggg atccaaggca cctggccatc tccaacatgc ccctggtgaa atctgtgaat      720

gttgctgaag gactcataga agaccatttt gacatcactg tgaagatgag tacctaccta      780

gtggccttca tcatttctga ttttaagtct gtgagcaaga tgactaagag tggagtcaag      840

gtttctgtgt atgctgtgcc agacaagata aatcaagccg attatgctct ggatgctgca      900

gtgactcttc tagagtttta tgaggattat ttcaacattc catatccttt acccaagcaa      960

gatcttgctg caatcccaga ctttcagtct ggtgctatgg aaaactgggg actgaccaca     1020

tacagagagt cctctctgtt atacgataaa gaaaagtctt ctgcatctag taagcttggc     1080

atcacaatga ttgtgtccca tgaactggct caccagtggt tcgggaacct ggtcaccatg     1140

gaatggtgga atgacctttg gctcaatgaa ggatttgcca aatttatgga gtttgtgtct     1200

gtcactgtga cccatcctga actaaaagtt gaagactatt tctttggcaa gtgttttaat     1260

gcaatggaag ttgatgcatt aaactcctct caccctgtat ccacacctgt ggagaatcct     1320

gcgcagattc gggagatgtt tgatgatgtt tcttatgaaa agggagcttg tattctgaat     1380

atgctaagag attatctgag tgcagataca tttaaaagag gaattgtaca gtatctccaa     1440

aagtatagtt ataaaaacac aaaaaacgag gacctgtgga atagcatgat gcatatttgc     1500

cctacagatg gcacacaaac aatggatggc ttctgctcta gaagccaaca ctcatcatca     1560

acctcacact ggcgtcagga ggttgtagat gtaaagacca tgatgaacac atggacactg     1620

cagaagggct ttcctctgat aaccatcact gtgagtgggc ggaatgtgca catgaagcaa     1680

gaacactaca tgaagggttc agaacgcttc ccagagactg ggtatttgtg gcatgttcca     1740

ctgacattca ttaccagcaa atcagactca gtccagagat ttttgctgaa gacaaagaca     1800

gatgtgctca tcctcccaga agcagtgcag tggatcaaat ttaacgtggg aatgaatggc     1860

tattacattg tgcattacgc ggatgatgga tgggcttctc tgagtggcct tttaaaagaa     1920

gcgcacacaa caatcagcag taatgatcgg gcaagtctca tcaacaatgc atttcagctg     1980

gtcagcattg aaaagttatc aatagaaaaa gccctggatt taaccctgta cttgaaaaat     2040

gaaactgaaa ttatgcccat attccaagct ttgaatgaac tcatacctat gtataagtta     2100

atggagaaaa gagatatgat tgaggtggaa actcaattta aggacttcct tctcaagttg     2160

ctgaaggacc ttattgataa gcagacttgg acagatgaag gctctgtctc agagaggatg     2220

ctcaggagcc agctcctcct cctcgcatgt gtgcgcaatt atcagccctg tgtgcagagg     2280

gcagagcgct atttcagaga gtggaagtca tctaatggaa acatgagcat ccctattgat     2340

gtgaccttgg ctgtgtttgc tgtcggggcc caaaacacag aaggctggga ttttctttat     2400

agtaaatatc agtcttcttt gtctagtact gagaaaagcc aaattgaatt ttccctctgt     2460

acaagcaaag atccagaaaa acttcagtgg cttctagatc aaagttttaa gggagagata     2520

ataaaaactc aggaatttcc acatattctc acactcattg gcagaaaccc agtgggttat     2580

ccattggcct ggaagtttct gagggaaaat tggaataagc ttgtacagaa atttgaactt     2640

ggctcatcgt ccatagctca catggtaatg ggaacaacag accagttttc caccagagca     2700

cgtcttgaag aggtaaaagg attcttcagt tccttgaaag aaaacggttc tcagctccgt     2760

tgtgttcaac aaaccattga gaccattgaa gaaaacatac gatggatgga taagaatttt     2820

gataaaataa gactgtggct gcaaaaagaa aagccagagt tgctgtgaca atatgtttct     2880

tgccaagttc cagaatttat gatgagcaaa attttgttca atttgagtat ttttaaacta     2940

aagatagttg ttttggctac tactgaagat attttcttat ttcatttcac ttgattatgt     3000

ctgagaaaag cttcaatgac tgtgattgac aggtttaaac ccaagtgccc agctccttgc     3060

cacagaaaaa cccagggggc ttcttctcag tttatacttc agcttctgtg tcggccattc     3120

atcagtattt ttgtaagact gaatagtgag gcataactgt gcagtgaatg cttggctcct     3180

tagccatgct gggaagtggc tgtgcagcag ccctcctgtt gacctctctg gctctacagt     3240

cctgcagtct ctcttcctgg gttcacttat gggtgctgcc ttgcaggatc cacttaatca     3300

gacacttttg ccctctggat tttgttaata gtgtttggta gttgttatcc atgagggatt     3360

gcatagaggt gtttattttc ttgtacttgc ctctggctgg ctttcaacca ccgtaagtct     3420

tactcctaag aggtggcctt tccccccccc ccccccccgc actctgataa ctacttcctt     3480

ttcatccttt ggggcatggg gcaacagtgg aaacctgctg ataccagtca tggtagtact     3540

tgtcattttc actgaaccta cgtgcacatt tgtttttaaa aatattgtat atctataacc     3600

ctcgttggat aagtcaaata tgagagccac ttactttctt tggaaggtta tttttaaaaa     3660

tgcagagtgc attcagatct gtatcagaaa tatctcgttt taagatatac ttgtgagtca     3720

ctgatccctt aagtagggag tagggttgta aattcctaaa taactcataa tagcacttac     3780

tgaaaataaa tcattgagga ctcactaaca aaggacaata ttaataatat gtttatatta     3840

gtataaggaa agattcttta aatcttaaaa agattttttt gatgtatggc ataaatgata     3900

ggaaaaatat caacatatgg tgctgtaata tactatgaaa taaagcgatt ttaggggttc     3960

aattatattt tcactggcct accaaaatac ttgagattaa atgaggaaag attt           4014


<210>  48
<211>  930
<212>  PRT
<213>  Mus musculus

<400>  48

Met Pro Ser Leu Leu Pro Leu Val Leu Thr Phe Leu Ser Val Ser Ser 
1               5                   10                  15      


Pro Ser Trp Cys Gln Asn Ser Asp Ile Glu Ser Leu Lys Ala Ser Asn 
            20                  25                  30          


Gly Asp Ser Phe Pro Trp Asn Asn Met Arg Leu Pro Glu Tyr Met Thr 
        35                  40                  45              


Pro Ile His Tyr Asp Leu Met Ile His Ala Asn Leu Ser Thr Leu Thr 
    50                  55                  60                  


Phe Trp Gly Lys Thr Glu Val Glu Ile Ile Ala Ser Arg Pro Thr Ser 
65                  70                  75                  80  


Thr Ile Ile Met His Ser His His Leu Gln Ile Ser Lys Ala Thr Leu 
                85                  90                  95      


Arg Arg Gly Ala Gly Glu Met Leu Ser Glu Glu Pro Leu Lys Val Leu 
            100                 105                 110         


Glu Tyr Pro Ala His Glu Gln Val Ala Leu Leu Ala Ala Gln Pro Leu 
        115                 120                 125             


Leu Ala Gly Ser Leu Tyr Thr Val Ile Ile Asp Tyr Ala Ala Asn Leu 
    130                 135                 140                 


Ser Glu Ser Phe His Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Gln Glu 
145                 150                 155                 160 


Gly Glu Met Arg Ile Leu Ala Ala Thr Gln Phe Glu Pro Thr Ala Ala 
                165                 170                 175     


Arg Met Ala Phe Pro Cys Phe Asp Glu Pro Ala Leu Lys Ala Ser Phe 
            180                 185                 190         


Ser Ile Lys Ile Lys Arg Asp Pro Arg His Leu Ala Ile Ser Asn Met 
        195                 200                 205             


Pro Leu Val Lys Ser Val Asn Val Ala Glu Gly Leu Ile Glu Asp His 
    210                 215                 220                 


Phe Asp Ile Thr Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Ile 
225                 230                 235                 240 


Ser Asp Phe Lys Ser Val Ser Lys Met Thr Lys Ser Gly Val Lys Val 
                245                 250                 255     


Ser Val Tyr Ala Val Pro Asp Lys Ile Asn Gln Ala Asp Tyr Ala Leu 
            260                 265                 270         


Asp Ala Ala Val Thr Leu Leu Glu Phe Tyr Glu Asp Tyr Phe Asn Ile 
        275                 280                 285             


Pro Tyr Pro Leu Pro Lys Gln Asp Leu Ala Ala Ile Pro Asp Phe Gln 
    290                 295                 300                 


Ser Gly Ala Met Glu Asn Trp Gly Leu Thr Thr Tyr Arg Glu Ser Ser 
305                 310                 315                 320 


Leu Leu Tyr Asp Lys Glu Lys Ser Ser Ala Ser Ser Lys Leu Gly Ile 
                325                 330                 335     


Thr Met Ile Val Ser His Glu Leu Ala His Gln Trp Phe Gly Asn Leu 
            340                 345                 350         


Val Thr Met Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala 
        355                 360                 365             


Lys Phe Met Glu Phe Val Ser Val Thr Val Thr His Pro Glu Leu Lys 
    370                 375                 380                 


Val Glu Asp Tyr Phe Phe Gly Lys Cys Phe Asn Ala Met Glu Val Asp 
385                 390                 395                 400 


Ala Leu Asn Ser Ser His Pro Val Ser Thr Pro Val Glu Asn Pro Ala 
                405                 410                 415     


Gln Ile Arg Glu Met Phe Asp Asp Val Ser Tyr Glu Lys Gly Ala Cys 
            420                 425                 430         


Ile Leu Asn Met Leu Arg Asp Tyr Leu Ser Ala Asp Thr Phe Lys Arg 
        435                 440                 445             


Gly Ile Val Gln Tyr Leu Gln Lys Tyr Ser Tyr Lys Asn Thr Lys Asn 
    450                 455                 460                 


Glu Asp Leu Trp Asn Ser Met Met His Ile Cys Pro Thr Asp Gly Thr 
465                 470                 475                 480 


Gln Thr Met Asp Gly Phe Cys Ser Arg Ser Gln His Ser Ser Ser Thr 
                485                 490                 495     


Ser His Trp Arg Gln Glu Val Val Asp Val Lys Thr Met Met Asn Thr 
            500                 505                 510         


Trp Thr Leu Gln Lys Gly Phe Pro Leu Ile Thr Ile Thr Val Ser Gly 
        515                 520                 525             


Arg Asn Val His Met Lys Gln Glu His Tyr Met Lys Gly Ser Glu Arg 
    530                 535                 540                 


Phe Pro Glu Thr Gly Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr 
545                 550                 555                 560 


Ser Lys Ser Asp Ser Val Gln Arg Phe Leu Leu Lys Thr Lys Thr Asp 
                565                 570                 575     


Val Leu Ile Leu Pro Glu Ala Val Gln Trp Ile Lys Phe Asn Val Gly 
            580                 585                 590         


Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp Gly Trp Ala Ser 
        595                 600                 605             


Leu Ser Gly Leu Leu Lys Glu Ala His Thr Thr Ile Ser Ser Asn Asp 
    610                 615                 620                 


Arg Ala Ser Leu Ile Asn Asn Ala Phe Gln Leu Val Ser Ile Glu Lys 
625                 630                 635                 640 


Leu Ser Ile Glu Lys Ala Leu Asp Leu Thr Leu Tyr Leu Lys Asn Glu 
                645                 650                 655     


Thr Glu Ile Met Pro Ile Phe Gln Ala Leu Asn Glu Leu Ile Pro Met 
            660                 665                 670         


Tyr Lys Leu Met Glu Lys Arg Asp Met Ile Glu Val Glu Thr Gln Phe 
        675                 680                 685             


Lys Asp Phe Leu Leu Lys Leu Leu Lys Asp Leu Ile Asp Lys Gln Thr 
    690                 695                 700                 


Trp Thr Asp Glu Gly Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu 
705                 710                 715                 720 


Leu Leu Leu Ala Cys Val Arg Asn Tyr Gln Pro Cys Val Gln Arg Ala 
                725                 730                 735     


Glu Arg Tyr Phe Arg Glu Trp Lys Ser Ser Asn Gly Asn Met Ser Ile 
            740                 745                 750         


Pro Ile Asp Val Thr Leu Ala Val Phe Ala Val Gly Ala Gln Asn Thr 
        755                 760                 765             


Glu Gly Trp Asp Phe Leu Tyr Ser Lys Tyr Gln Ser Ser Leu Ser Ser 
    770                 775                 780                 


Thr Glu Lys Ser Gln Ile Glu Phe Ser Leu Cys Thr Ser Lys Asp Pro 
785                 790                 795                 800 


Glu Lys Leu Gln Trp Leu Leu Asp Gln Ser Phe Lys Gly Glu Ile Ile 
                805                 810                 815     


Lys Thr Gln Glu Phe Pro His Ile Leu Thr Leu Ile Gly Arg Asn Pro 
            820                 825                 830         


Val Gly Tyr Pro Leu Ala Trp Lys Phe Leu Arg Glu Asn Trp Asn Lys 
        835                 840                 845             


Leu Val Gln Lys Phe Glu Leu Gly Ser Ser Ser Ile Ala His Met Val 
    850                 855                 860                 


Met Gly Thr Thr Asp Gln Phe Ser Thr Arg Ala Arg Leu Glu Glu Val 
865                 870                 875                 880 


Lys Gly Phe Phe Ser Ser Leu Lys Glu Asn Gly Ser Gln Leu Arg Cys 
                885                 890                 895     


Val Gln Gln Thr Ile Glu Thr Ile Glu Glu Asn Ile Arg Trp Met Asp 
            900                 905                 910         


Lys Asn Phe Asp Lys Ile Arg Leu Trp Leu Gln Lys Glu Lys Pro Glu 
        915                 920                 925             


Leu Leu 
    930 


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  49
gcctgctgtc acttgctacg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  50
aatcaaccag agaatttccg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  51
ggtccagctc ccgttctaca                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  52
gtatggcagc aacgtcacga                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  53
tatagagctg aaaaaccgca                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  54
ccacattacg gacgatgcaa                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  55
tcttacgagg aggagaaagg                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  56
gcaagtgtag tttcccacca                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  57
gcgaggtatt cggctccgcg                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  58
gctttcacgg aggttcgacg                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  59
atgttgcagt tcggctcgat                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  60
acgtgtaagg cgaacgcctt                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  61
attgttcgac cgtctacggg                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  62
tagccgacaa tgatgaaccg                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  63
aggcctcctg acaatacccg                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  64
ggaacttcag agtaaacctg                                                   20


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: OVA epitope peptide sequence"

<400>  65

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5