                         SEQUENCE LISTING

<110>  VIB VZW
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
 
<120>  TARGETING SYNAPTOGYRIN-3 IN TAUOPATHY TREATMENT

<130>  PV/SYNG3/596

<150>  EP 17181659.8
<151>  2017-07-17

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Gly Ala Ser Phe Gly Ala Gly Arg Ala Gly Ala Ala Leu Asp 
1               5                   10                  15      


Pro Val Ser Phe Ala Arg Arg Pro Gln Thr Leu Leu Arg Val Ala Ser 
            20                  25                  30          


Trp Val Phe Ser Ile Ala Val Phe Gly Pro Ile Val Asn Glu Gly Tyr 
        35                  40                  45              


Val Asn Thr Asp Ser Gly Pro Glu Leu Arg Cys Val Phe Asn Gly Asn 
    50                  55                  60                  


Ala Gly Ala Cys Arg Phe Gly Val Ala Leu Gly Leu Gly Ala Phe Leu 
65                  70                  75                  80  


Ala Cys Ala Ala Phe Leu Leu Leu Asp Val Arg Phe Gln Gln Ile Ser 
                85                  90                  95      


Ser Val Arg Asp Arg Arg Arg Ala Val Leu Leu Asp Leu Gly Phe Ser 
            100                 105                 110         


Gly Leu Trp Ser Phe Leu Trp Phe Val Gly Phe Cys Phe Leu Thr Asn 
        115                 120                 125             


Gln Trp Gln Arg Thr Ala Pro Gly Pro Ala Thr Thr Gln Ala Gly Asp 
    130                 135                 140                 


Ala Ala Arg Ala Ala Ile Ala Phe Ser Phe Phe Ser Ile Leu Ser Trp 
145                 150                 155                 160 


Val Ala Leu Thr Val Lys Ala Leu Gln Arg Phe Arg Leu Gly Thr Asp 
                165                 170                 175     


Met Ser Leu Phe Ala Thr Glu Gln Leu Ser Thr Gly Ala Ser Gln Ala 
            180                 185                 190         


Tyr Pro Gly Tyr Pro Val Gly Ser Gly Val Glu Gly Thr Glu Thr Tyr 
        195                 200                 205             


Gln Ser Pro Pro Phe Thr Glu Thr Leu Asp Thr Ser Pro Lys Gly Tyr 
    210                 215                 220                 


Gln Val Pro Ala Tyr 
225                 


<210>  2
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gly Ala Ser Phe Gly Ala Gly Arg Ala Gly Ala Ala Leu Asp 
1               5                   10                  15      


Pro Val Ser Phe Ala Arg Arg Pro Gln Thr Leu Leu Arg 
            20                  25                  


<210>  3
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Phe Gln Gln Ile Ser Ser Val Arg Asp Arg Arg Arg Ala 
1               5                   10                  


<210>  4
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Arg Phe Arg Leu Gly Thr Asp Met Ser Leu Phe Ala Thr Glu Gln 
1               5                   10                  15      


Leu Ser Thr Gly Ala Ser Gln Ala Tyr Pro Gly Tyr Pro Val Gly Ser 
            20                  25                  30          


Gly Val Glu Gly Thr Glu Thr Tyr Gln Ser Pro Pro Phe Thr Glu Thr 
        35                  40                  45              


Leu Asp Thr Ser Pro Lys Gly Tyr Gln Val Pro Ala Tyr 
    50                  55                  60      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TATp;protein

<400>  5

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAP protein

<400>  6

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  penetratin protein

<400>  7

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  8
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


<210>  9
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
    130                 135                 140     


<210>  10
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
                165                 170 


<210>  11
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
ggggacacgt ctccacggca tctcagcaat gtctcc                                 36


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
tcccccagcc tagaccacga gaat                                              24


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
caaatgttgc ttgtctggtg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
gtcagtcgag tgcacagttt                                                   20


<210>  15
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  syngr3A shRNA

<400>  15
gttcgtaggc ttctgtttcc tcaccaatc                                         29


<210>  16
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  syngr3B shRNA

<400>  16
gagcctgccg cttcggcgtc gtactaggt                                         29


<210>  17
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scramble shRNA

<400>  17
gcactaccag agctaactca gatagtact                                         29


