                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique
 
<120>  Methods for purifying proteins having a tubulin carboxypeptidase 
       activity and peptidic based inhibitors thereof

<130>  B2543PC00

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Leu Tyr Ser Val Thr Val Lys Trp Gly Lys Glu Lys Phe Glu 
1               5                   10                  15      


Gly Val Glu Leu Asn Thr Asp Glu Pro Pro Met Val Phe Lys Ala Gln 
            20                  25                  30          


Leu Phe Ala Leu Thr Gly Val Gln Pro Ala Arg Gln Lys Val Met Val 
        35                  40                  45              


Lys Gly Gly Thr Leu Lys Asp Asp Asp Trp Gly Asn Ile Lys Ile Lys 
    50                  55                  60                  


Asn Gly Met Thr Leu Leu Met Met Gly Ser Ala Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Glu Pro Ser Ala Lys Thr Val Phe Val Glu Asp Met Thr Glu Glu Gln 
                85                  90                  95      


Leu Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn 
            100                 105                 110         


Thr Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu 
        115                 120                 125             


Leu Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly 
    130                 135                 140                 


Glu Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe 
145                 150                 155                 160 


Asp Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu 
                165                 170                 175     


Gln Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln 
            180                 185                 190         


Gly Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met 
        195                 200                 205             


Arg Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys 
    210                 215                 220                 


Glu Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys 
225                 230                 235                 240 


Ser Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys 
                245                 250                 255     


Cys Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln 
            260                 265                 270         


Leu Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr 
        275                 280                 285             


Gly Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr 
    290                 295                 300                 


Leu Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu 
305                 310                 315                 320 


Pro Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys 
                325                 330                 335     


Glu Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met 
            340                 345                 350         


Leu Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val 
        355                 360                 365             


Ser Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln 
    370                 375                 380                 


Gln Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys 
385                 390                 395                 400 


Tyr Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly 
                405                 410                 415     


Tyr Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser 
            420                 425                 430         


Ser Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile 
        435                 440                 445             


Lys Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu 
    450                 455                 460                 


Arg Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr 
465                 470                 475                 480 


Gly Pro Arg Arg Val Glu Ile Met Glu Glu Glu Ser Glu Gln 
                485                 490                 


<210>  2
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile 
1               5                   10                  15      


Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe 
            20                  25                  30          


Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn 
        35                  40                  45              


Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys 
    50                  55                  60                  


Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys 
65                  70                  75                  80  


Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro 
                85                  90                  95      


Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu 
            100                 105                 110         


Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr 
        115                 120                 125             


Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg 
    130                 135                 140                 


Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala 
145                 150                 155                 160 


Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val 
                165                 170                 175     


Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile 
            180                 185                 190         


Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu 
        195                 200                 205             


Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe 
    210                 215                 220                 


Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr 
225                 230                 235                 240 


Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala 
                245                 250                 255     


Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu 
            260                 265                 270         


Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys 
        275                 280                 285             


Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile 
    290                 295                 300                 


Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu 
305                 310                 315                 320 


Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
                325                 330                 335     


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            340                 345                 350         


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        355                 360                 365             


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    370                 375                 380                 


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
385                 390                 395                 400 


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                405                 410                 415     


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            420                 425                 430         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        435                 440                 445             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    450                 455                 460                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
465                 470                 475                 480 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                485                 490                 495     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            500                 505                 510         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        515                 520                 525             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    530                 535                 540                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
545                 550                 555                 560 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                565                 570                 575     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            580                 585                 590         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        595                 600                 605             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    610                 615                 620                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
625                 630                 635                 640 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                645                 650                 655     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            660                 665                 670         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        675                 680                 685             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    690                 695                 700                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
705                 710                 715                 720 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                725                 730                 735     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            740                 745                 750         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        755                 760                 765             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    770                 775                 780                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
785                 790                 795                 800 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                805                 810                 815     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            820                 825                 830         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        835                 840                 845             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser 
    850                 855             


<210>  3
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Val Glu Glu Val Ala Ala Ser Gly Ser His Leu Asn Gly 
1               5                   10                  15      


Asp Leu Asp Pro Asp Asp Arg Glu Glu Gly Ala Ala Ser Thr Ala Glu 
            20                  25                  30          


Glu Ala Ala Lys Lys Lys Arg Arg Lys Lys Lys Lys Ser Lys Gly Pro 
        35                  40                  45              


Ser Ala Ala Gly Glu Gln Glu Pro Asp Lys Glu Ser Gly Ala Ser Val 
    50                  55                  60                  


Asp Glu Val Ala Arg Gln Leu Glu Arg Ser Ala Leu Glu Asp Lys Glu 
65                  70                  75                  80  


Arg Asp Glu Asp Asp Glu Asp Gly Asp Gly Asp Gly Asp Gly Ala Thr 
                85                  90                  95      


Gly Lys Lys Lys Lys Lys Lys Lys Lys Lys Arg Gly Pro Lys Val Gln 
            100                 105                 110         


Thr Asp Pro Pro Ser Val Pro Ile Cys Asp Leu Tyr Pro Asn Gly Val 
        115                 120                 125             


Phe Pro Lys Gly Gln Glu Cys Glu Tyr Pro Pro Thr Gln Asp Gly Arg 
    130                 135                 140                 


Thr Ala Ala Trp Arg Thr Thr Ser Glu Glu Lys Lys Ala Leu Asp Gln 
145                 150                 155                 160 


Ala Ser Glu Glu Ile Trp Asn Asp Phe Arg Glu Ala Ala Glu Ala His 
                165                 170                 175     


Arg Gln Val Arg Lys Tyr Val Met Ser Trp Ile Lys Pro Gly Met Thr 
            180                 185                 190         


Met Ile Glu Ile Cys Glu Lys Leu Glu Asp Cys Ser Arg Lys Leu Ile 
        195                 200                 205             


Lys Glu Asn Gly Leu Asn Ala Gly Leu Ala Phe Pro Thr Gly Cys Ser 
    210                 215                 220                 


Leu Asn Asn Cys Ala Ala His Tyr Thr Pro Asn Ala Gly Asp Thr Thr 
225                 230                 235                 240 


Val Leu Gln Tyr Asp Asp Ile Cys Lys Ile Asp Phe Gly Thr His Ile 
                245                 250                 255     


Ser Gly Arg Ile Ile Asp Cys Ala Phe Thr Val Thr Phe Asn Pro Lys 
            260                 265                 270         


Tyr Asp Thr Leu Leu Lys Ala Val Lys Asp Ala Thr Asn Thr Gly Ile 
        275                 280                 285             


Lys Cys Ala Gly Ile Asp Val Arg Leu Cys Asp Val Gly Glu Ala Ile 
    290                 295                 300                 


Gln Glu Val Met Glu Ser Tyr Glu Val Glu Ile Asp Gly Lys Thr Tyr 
305                 310                 315                 320 


Gln Val Lys Pro Ile Arg Asn Leu Asn Gly His Ser Ile Gly Gln Tyr 
                325                 330                 335     


Arg Ile His Ala Gly Lys Thr Val Pro Ile Val Lys Gly Gly Glu Ala 
            340                 345                 350         


Thr Arg Met Glu Glu Gly Glu Val Tyr Ala Ile Glu Thr Phe Gly Ser 
        355                 360                 365             


Thr Gly Lys Gly Val Val His Asp Asp Met Glu Cys Ser His Tyr Met 
    370                 375                 380                 


Lys Asn Phe Asp Val Gly His Val Pro Ile Arg Leu Pro Arg Thr Lys 
385                 390                 395                 400 


His Leu Leu Asn Val Ile Asn Glu Asn Phe Gly Thr Leu Ala Phe Cys 
                405                 410                 415     


Arg Arg Trp Leu Asp Arg Leu Gly Glu Ser Lys Tyr Leu Met Ala Leu 
            420                 425                 430         


Lys Asn Leu Cys Asp Leu Gly Ile Val Asp Pro Tyr Pro Pro Leu Cys 
        435                 440                 445             


Asp Ile Lys Gly Ser Tyr Thr Ala Gln Phe Glu His Thr Ile Leu Leu 
    450                 455                 460                 


Arg Pro Thr Cys Lys Glu Val Val Ser Arg Gly Asp Asp Tyr 
465                 470                 475             


<210>  4
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Pro Lys Val Thr Ser Glu Leu Leu Arg Gln Leu Arg Gln Ala 
1               5                   10                  15      


Met Arg Asn Ser Glu Tyr Val Thr Glu Pro Ile Gln Ala Tyr Ile Ile 
            20                  25                  30          


Pro Ser Gly Asp Ala His Gln Ser Glu Tyr Ile Ala Pro Cys Asp Cys 
        35                  40                  45              


Arg Arg Ala Phe Val Ser Gly Phe Asp Gly Ser Ala Gly Thr Ala Ile 
    50                  55                  60                  


Ile Thr Glu Glu His Ala Ala Met Trp Thr Asp Gly Arg Tyr Phe Leu 
65                  70                  75                  80  


Gln Ala Ala Lys Gln Met Asp Ser Asn Trp Thr Leu Met Lys Met Gly 
                85                  90                  95      


Leu Lys Asp Thr Pro Thr Gln Glu Asp Trp Leu Val Ser Val Leu Pro 
            100                 105                 110         


Glu Gly Ser Arg Val Gly Val Asp Pro Leu Ile Ile Pro Thr Asp Tyr 
        115                 120                 125             


Trp Lys Lys Met Ala Lys Val Leu Arg Ser Ala Gly His His Leu Ile 
    130                 135                 140                 


Pro Val Lys Glu Asn Leu Val Asp Lys Ile Trp Thr Asp Arg Pro Glu 
145                 150                 155                 160 


Arg Pro Cys Lys Pro Leu Leu Thr Leu Gly Leu Asp Tyr Thr Gly Ile 
                165                 170                 175     


Ser Trp Lys Asp Lys Val Ala Asp Leu Arg Leu Lys Met Ala Glu Arg 
            180                 185                 190         


Asn Val Met Trp Phe Val Val Thr Ala Leu Asp Glu Ile Ala Trp Leu 
        195                 200                 205             


Phe Asn Leu Arg Gly Ser Asp Val Glu His Asn Pro Val Phe Phe Ser 
    210                 215                 220                 


Tyr Ala Ile Ile Gly Leu Glu Thr Ile Met Leu Phe Ile Asp Gly Asp 
225                 230                 235                 240 


Arg Ile Asp Ala Pro Ser Val Lys Glu His Leu Leu Leu Asp Leu Gly 
                245                 250                 255     


Leu Glu Ala Glu Tyr Arg Ile Gln Val His Pro Tyr Lys Ser Ile Leu 
            260                 265                 270         


Ser Glu Leu Lys Ala Leu Cys Ala Asp Leu Ser Pro Arg Glu Lys Val 
        275                 280                 285             


Trp Val Ser Asp Lys Ala Ser Tyr Ala Val Ser Glu Thr Ile Pro Lys 
    290                 295                 300                 


Asp His Arg Cys Cys Met Pro Tyr Thr Pro Ile Cys Ile Ala Lys Ala 
305                 310                 315                 320 


Val Lys Asn Ser Ala Glu Ser Glu Gly Met Arg Arg Ala His Ile Lys 
                325                 330                 335     


Asp Ala Val Ala Leu Cys Glu Leu Phe Asn Trp Leu Glu Lys Glu Val 
            340                 345                 350         


Pro Lys Gly Gly Val Thr Glu Ile Ser Ala Ala Asp Lys Ala Glu Glu 
        355                 360                 365             


Phe Arg Arg Gln Gln Ala Asp Phe Val Asp Leu Ser Phe Pro Thr Ile 
    370                 375                 380                 


Ser Ser Thr Gly Pro Asn Gly Ala Ile Ile His Tyr Ala Pro Val Pro 
385                 390                 395                 400 


Glu Thr Asn Arg Thr Leu Ser Leu Asp Glu Val Tyr Leu Ile Asp Ser 
                405                 410                 415     


Gly Ala Gln Tyr Lys Asp Gly Thr Thr Asp Val Thr Arg Thr Met His 
            420                 425                 430         


Phe Gly Thr Pro Thr Ala Tyr Glu Lys Glu Cys Phe Thr Tyr Val Leu 
        435                 440                 445             


Lys Gly His Ile Ala Val Ser Ala Ala Val Phe Pro Thr Gly Thr Lys 
    450                 455                 460                 


Gly His Leu Leu Asp Ser Phe Ala Arg Ser Ala Leu Trp Asp Ser Gly 
465                 470                 475                 480 


Leu Asp Tyr Leu His Gly Thr Gly His Gly Val Gly Ser Phe Leu Asn 
                485                 490                 495     


Val His Glu Gly Pro Cys Gly Ile Ser Tyr Lys Thr Phe Ser Asp Glu 
            500                 505                 510         


Pro Leu Glu Ala Gly Met Ile Val Thr Asp Glu Pro Gly Tyr Tyr Glu 
        515                 520                 525             


Asp Gly Ala Phe Gly Ile Arg Ile Glu Asn Val Val Leu Val Val Pro 
    530                 535                 540                 


Val Lys Thr Lys Tyr Asn Phe Asn Asn Arg Gly Ser Leu Thr Phe Glu 
545                 550                 555                 560 


Pro Leu Thr Leu Val Pro Ile Gln Thr Lys Met Ile Asp Val Asp Ser 
                565                 570                 575     


Leu Thr Asp Lys Glu Cys Asp Trp Leu Asn Asn Tyr His Leu Thr Cys 
            580                 585                 590         


Arg Asp Val Ile Gly Lys Glu Leu Gln Lys Gln Gly Arg Gln Glu Ala 
        595                 600                 605             


Leu Glu Trp Leu Ile Arg Glu Thr Gln Pro Ile Ser Lys Gln His 
    610                 615                 620             


<210>  5
<211>  1249
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Thr Ala Ala Thr Glu Glu Pro Phe Pro Phe His Gly Leu Leu 
1               5                   10                  15      


Pro Lys Lys Glu Thr Gly Ala Ala Ser Phe Leu Cys Arg Tyr Pro Glu 
            20                  25                  30          


Tyr Asp Gly Arg Gly Val Leu Ile Ala Val Leu Asp Thr Gly Val Asp 
        35                  40                  45              


Pro Gly Ala Pro Gly Met Gln Val Thr Thr Asp Gly Lys Pro Lys Ile 
    50                  55                  60                  


Val Asp Ile Ile Asp Thr Thr Gly Ser Gly Asp Val Asn Thr Ala Thr 
65                  70                  75                  80  


Glu Val Glu Pro Lys Asp Gly Glu Ile Val Gly Leu Ser Gly Arg Val 
                85                  90                  95      


Leu Lys Ile Pro Ala Ser Trp Thr Asn Pro Ser Gly Lys Tyr His Ile 
            100                 105                 110         


Gly Ile Lys Asn Gly Tyr Asp Phe Tyr Pro Lys Ala Leu Lys Glu Arg 
        115                 120                 125             


Ile Gln Lys Glu Arg Lys Glu Lys Ile Trp Asp Pro Val His Arg Val 
    130                 135                 140                 


Ala Leu Ala Glu Ala Cys Arg Lys Gln Glu Glu Phe Asp Val Ala Asn 
145                 150                 155                 160 


Asn Gly Ser Ser Gln Ala Asn Lys Leu Ile Lys Glu Glu Leu Gln Ser 
                165                 170                 175     


Gln Val Glu Leu Leu Asn Ser Phe Glu Lys Lys Tyr Ser Asp Pro Gly 
            180                 185                 190         


Pro Val Tyr Asp Cys Leu Val Trp His Asp Gly Glu Val Trp Arg Ala 
        195                 200                 205             


Cys Ile Asp Ser Asn Glu Asp Gly Asp Leu Ser Lys Ser Thr Val Leu 
    210                 215                 220                 


Arg Asn Tyr Lys Glu Ala Gln Glu Tyr Gly Ser Phe Gly Thr Ala Glu 
225                 230                 235                 240 


Met Leu Asn Tyr Ser Val Asn Ile Tyr Asp Asp Gly Asn Leu Leu Ser 
                245                 250                 255     


Ile Val Thr Ser Gly Gly Ala His Gly Thr His Val Ala Ser Ile Ala 
            260                 265                 270         


Ala Gly His Phe Pro Glu Glu Pro Glu Arg Asn Gly Val Ala Pro Gly 
        275                 280                 285             


Ala Gln Ile Leu Ser Ile Lys Ile Gly Asp Thr Arg Leu Ser Thr Met 
    290                 295                 300                 


Glu Thr Gly Thr Gly Leu Ile Arg Ala Met Ile Glu Val Ile Asn His 
305                 310                 315                 320 


Lys Cys Asp Leu Val Asn Tyr Ser Tyr Gly Glu Ala Thr His Trp Pro 
                325                 330                 335     


Asn Ser Gly Arg Ile Cys Glu Val Ile Asn Glu Ala Val Trp Lys His 
            340                 345                 350         


Asn Ile Ile Tyr Val Ser Ser Ala Gly Asn Asn Gly Pro Cys Leu Ser 
        355                 360                 365             


Thr Val Gly Cys Pro Gly Gly Thr Thr Ser Ser Val Ile Gly Val Gly 
    370                 375                 380                 


Ala Tyr Val Ser Pro Asp Met Met Val Ala Glu Tyr Ser Leu Arg Glu 
385                 390                 395                 400 


Lys Leu Pro Ala Asn Gln Tyr Thr Trp Ser Ser Arg Gly Pro Ser Ala 
                405                 410                 415     


Asp Gly Ala Leu Gly Val Ser Ile Ser Ala Pro Gly Gly Ala Ile Ala 
            420                 425                 430         


Ser Val Pro Asn Trp Thr Leu Arg Gly Thr Gln Leu Met Asn Gly Thr 
        435                 440                 445             


Ser Met Ser Ser Pro Asn Ala Cys Gly Gly Ile Ala Leu Ile Leu Ser 
    450                 455                 460                 


Gly Leu Lys Ala Asn Asn Ile Asp Tyr Thr Val His Ser Val Arg Arg 
465                 470                 475                 480 


Ala Leu Glu Asn Thr Ala Val Lys Ala Asp Asn Ile Glu Val Phe Ala 
                485                 490                 495     


Gln Gly His Gly Ile Ile Gln Val Asp Lys Ala Tyr Asp Tyr Leu Val 
            500                 505                 510         


Gln Asn Thr Ser Phe Ala Asn Lys Leu Gly Phe Thr Val Thr Val Gly 
        515                 520                 525             


Asn Asn Arg Gly Ile Tyr Leu Arg Asp Pro Val Gln Val Ala Ala Pro 
    530                 535                 540                 


Ser Asp His Gly Val Gly Ile Glu Pro Val Phe Pro Glu Asn Thr Glu 
545                 550                 555                 560 


Asn Ser Glu Lys Ile Ser Leu Gln Leu His Leu Ala Leu Thr Ser Asn 
                565                 570                 575     


Ser Ser Trp Val Gln Cys Pro Ser His Leu Glu Leu Met Asn Gln Cys 
            580                 585                 590         


Arg His Ile Asn Ile Arg Val Asp Pro Arg Gly Leu Arg Glu Gly Leu 
        595                 600                 605             


His Tyr Thr Glu Val Cys Gly Tyr Asp Ile Ala Ser Pro Asn Ala Gly 
    610                 615                 620                 


Pro Leu Phe Arg Val Pro Ile Thr Ala Val Ile Ala Ala Lys Val Asn 
625                 630                 635                 640 


Glu Ser Ser His Tyr Asp Leu Ala Phe Thr Asp Val His Phe Lys Pro 
                645                 650                 655     


Gly Gln Ile Arg Arg His Phe Ile Glu Val Pro Glu Gly Ala Thr Trp 
            660                 665                 670         


Ala Glu Val Thr Val Cys Ser Cys Ser Ser Glu Val Ser Ala Lys Phe 
        675                 680                 685             


Val Leu His Ala Val Gln Leu Val Lys Gln Arg Ala Tyr Arg Ser His 
    690                 695                 700                 


Glu Phe Tyr Lys Phe Cys Ser Leu Pro Glu Lys Gly Thr Leu Thr Glu 
705                 710                 715                 720 


Ala Phe Pro Val Leu Gly Gly Lys Ala Ile Glu Phe Cys Ile Ala Arg 
                725                 730                 735     


Trp Trp Ala Ser Leu Ser Asp Val Asn Ile Asp Tyr Thr Ile Ser Phe 
            740                 745                 750         


His Gly Ile Val Cys Thr Ala Pro Gln Leu Asn Ile His Ala Ser Glu 
        755                 760                 765             


Gly Ile Asn Arg Phe Asp Val Gln Ser Ser Leu Lys Tyr Glu Asp Leu 
    770                 775                 780                 


Ala Pro Cys Ile Thr Leu Lys Asn Trp Val Gln Thr Leu Arg Pro Val 
785                 790                 795                 800 


Ser Ala Lys Thr Lys Pro Leu Gly Ser Arg Asp Val Leu Pro Asn Asn 
                805                 810                 815     


Arg Gln Leu Tyr Glu Met Val Leu Thr Tyr Asn Phe His Gln Pro Lys 
            820                 825                 830         


Ser Gly Glu Val Thr Pro Ser Cys Pro Leu Leu Cys Glu Leu Leu Tyr 
        835                 840                 845             


Glu Ser Glu Phe Asp Ser Gln Leu Trp Ile Ile Phe Asp Gln Asn Lys 
    850                 855                 860                 


Arg Gln Met Gly Ser Gly Asp Ala Tyr Pro His Gln Tyr Ser Leu Lys 
865                 870                 875                 880 


Leu Glu Lys Gly Asp Tyr Thr Ile Arg Leu Gln Ile Arg His Glu Gln 
                885                 890                 895     


Ile Ser Asp Leu Glu Arg Leu Lys Asp Leu Pro Phe Ile Val Ser His 
            900                 905                 910         


Arg Leu Ser Asn Thr Leu Ser Leu Asp Ile His Glu Asn His Ser Phe 
        915                 920                 925             


Ala Leu Leu Gly Lys Lys Lys Ser Ser Asn Leu Thr Leu Pro Pro Lys 
    930                 935                 940                 


Tyr Asn Gln Pro Phe Phe Val Thr Ser Leu Pro Asp Asp Lys Ile Pro 
945                 950                 955                 960 


Lys Gly Ala Gly Pro Gly Cys Tyr Leu Ala Gly Ser Leu Thr Leu Ser 
                965                 970                 975     


Lys Thr Glu Leu Gly Lys Lys Ala Asp Val Ile Pro Val His Tyr Tyr 
            980                 985                 990         


Leu Ile Pro Pro Pro Thr Lys Thr  Lys Asn Gly Ser Lys  Asp Lys Glu 
        995                 1000                 1005             


Lys Asp  Ser Glu Lys Glu Lys  Asp Leu Lys Glu Glu  Phe Thr Glu 
    1010                 1015                 1020             


Ala Leu  Arg Asp Leu Lys Ile  Gln Trp Met Thr Lys  Leu Asp Ser 
    1025                 1030                 1035             


Ser Asp  Ile Tyr Asn Glu Leu  Lys Glu Thr Tyr Pro  Asn Tyr Leu 
    1040                 1045                 1050             


Pro Leu  Tyr Val Ala Arg Leu  His Gln Leu Asp Ala  Glu Lys Glu 
    1055                 1060                 1065             


Arg Met  Lys Arg Leu Asn Glu  Ile Val Asp Ala Ala  Asn Ala Val 
    1070                 1075                 1080             


Ile Ser  His Ile Asp Gln Thr  Ala Leu Ala Val Tyr  Ile Ala Met 
    1085                 1090                 1095             


Lys Thr  Asp Pro Arg Pro Asp  Ala Ala Thr Ile Lys  Asn Asp Met 
    1100                 1105                 1110             


Asp Lys  Gln Lys Ser Thr Leu  Val Asp Ala Leu Cys  Arg Lys Gly 
    1115                 1120                 1125             


Cys Ala  Leu Ala Asp His Leu  Leu His Thr Gln Ala  Gln Asp Gly 
    1130                 1135                 1140             


Ala Ile  Ser Thr Asp Ala Glu  Gly Lys Glu Glu Glu  Gly Glu Ser 
    1145                 1150                 1155             


Pro Leu  Asp Ser Leu Ala Glu  Thr Phe Trp Glu Thr  Thr Lys Trp 
    1160                 1165                 1170             


Thr Asp  Leu Phe Asp Asn Lys  Val Leu Thr Phe Ala  Tyr Lys His 
    1175                 1180                 1185             


Ala Leu  Val Asn Lys Met Tyr  Gly Arg Gly Leu Lys  Phe Ala Thr 
    1190                 1195                 1200             


Lys Leu  Val Glu Glu Lys Pro  Thr Lys Glu Asn Trp  Lys Asn Cys 
    1205                 1210                 1215             


Ile Gln  Leu Met Lys Leu Leu  Gly Trp Thr His Cys  Ala Ser Phe 
    1220                 1225                 1230             


Thr Glu  Asn Trp Leu Pro Ile  Met Tyr Pro Pro Asp  Tyr Cys Val 
    1235                 1240                 1245             


Phe 
    


<210>  6
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Gly Gly Lys Lys Val Ala Gly Gly Gly Ser Ser Gly Ala Thr 
1               5                   10                  15      


Pro Thr Ser Ala Ala Ala Thr Ala Pro Ser Gly Val Arg Arg Leu Glu 
            20                  25                  30          


Thr Ser Glu Gly Thr Ser Ala Gln Arg Asp Glu Glu Pro Glu Glu Glu 
        35                  40                  45              


Gly Glu Glu Asp Leu Arg Asp Gly Gly Val Pro Phe Phe Val Asn Arg 
    50                  55                  60                  


Gly Gly Leu Pro Val Asp Glu Ala Thr Trp Glu Arg Met Trp Lys His 
65                  70                  75                  80  


Val Ala Lys Ile His Pro Asp Gly Glu Lys Val Ala Gln Arg Ile Arg 
                85                  90                  95      


Gly Ala Thr Asp Leu Pro Lys Ile Pro Ile Pro Ser Val Pro Thr Phe 
            100                 105                 110         


Gln Pro Ser Thr Pro Val Pro Glu Arg Leu Glu Ala Val Gln Arg Tyr 
        115                 120                 125             


Ile Arg Glu Leu Gln Tyr Asn His Thr Gly Thr Gln Phe Phe Glu Ile 
    130                 135                 140                 


Lys Lys Ser Arg Pro Leu Thr Gly Leu Met Asp Leu Ala Lys Glu Met 
145                 150                 155                 160 


Thr Lys Glu Ala Leu Pro Ile Lys Cys Leu Glu Ala Val Ile Leu Gly 
                165                 170                 175     


Ile Tyr Leu Thr Asn Ser Met Pro Thr Leu Glu Arg Phe Pro Ile Ser 
            180                 185                 190         


Phe Lys Thr Tyr Phe Ser Gly Asn Tyr Phe Arg His Ile Val Leu Gly 
        195                 200                 205             


Val Asn Phe Ala Gly Arg Tyr Gly Ala Leu Gly Met Ser Arg Arg Glu 
    210                 215                 220                 


Asp Leu Met Tyr Lys Pro Pro Ala Phe Arg Thr Leu Ser Glu Leu Val 
225                 230                 235                 240 


Leu Asp Phe Glu Ala Ala Tyr Gly Arg Cys Trp His Val Leu Lys Lys 
                245                 250                 255     


Val Lys Leu Gly Gln Ser Val Ser His Asp Pro His Ser Val Glu Gln 
            260                 265                 270         


Ile Glu Trp Lys His Ser Val Leu Asp Val Glu Arg Leu Gly Arg Asp 
        275                 280                 285             


Asp Phe Arg Lys Glu Leu Glu Arg His Ala Arg Asp Met Arg Leu Lys 
    290                 295                 300                 


Ile Gly Lys Gly Thr Gly Pro Pro Ser Pro Thr Lys Asp Arg Lys Lys 
305                 310                 315                 320 


Asp Val Ser Ser Pro Gln Arg Ala Gln Ser Ser Pro His Arg Arg Asn 
                325                 330                 335     


Ser Arg Ser Glu Arg Arg Pro Ser Gly Asp Lys Lys Thr Ser Glu Pro 
            340                 345                 350         


Lys Ala Met Pro Asp Leu Asn Gly Tyr Gln Ile Arg Val 
        355                 360                 365 


<210>  7
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Tyr Gln Gly Lys Lys Ser Ile Pro His Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Lys Gly Gly Arg Ile Ile Asn Asp Asp Gln Ser Leu Tyr 
            20                  25                  30          


Ala Asp Val Tyr Leu Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly Arg Met 
    50                  55                  60                  


Val Ile Pro Gly Gly Ile Asp Val Asn Thr Tyr Leu Gln Lys Pro Ser 
65                  70                  75                  80  


Gln Gly Met Thr Ala Ala Asp Asp Phe Phe Gln Gly Thr Arg Ala Ala 
                85                  90                  95      


Leu Val Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
            100                 105                 110         


Gly Ser Ser Leu Leu Thr Ser Phe Glu Lys Trp His Glu Ala Ala Asp 
        115                 120                 125             


Thr Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Ser Trp 
    130                 135                 140                 


Tyr Asp Gly Val Arg Glu Glu Leu Glu Val Leu Val Gln Asp Lys Gly 
145                 150                 155                 160 


Val Asn Ser Phe Gln Val Tyr Met Ala Tyr Lys Asp Val Tyr Gln Met 
                165                 170                 175     


Ser Asp Ser Gln Leu Tyr Glu Ala Phe Thr Phe Leu Lys Gly Leu Gly 
            180                 185                 190         


Ala Val Ile Leu Val His Ala Glu Asn Gly Asp Leu Ile Ala Gln Glu 
        195                 200                 205             


Gln Lys Arg Ile Leu Glu Met Gly Ile Thr Gly Pro Glu Gly His Ala 
    210                 215                 220                 


Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg Ala Ile 
225                 230                 235                 240 


Thr Ile Ala Gly Arg Ile Asn Cys Pro Val Tyr Ile Thr Lys Val Met 
                245                 250                 255     


Ser Lys Ser Ala Ala Asp Ile Ile Ala Leu Ala Arg Lys Lys Gly Pro 
            260                 265                 270         


Leu Val Phe Gly Glu Pro Ile Ala Ala Ser Leu Gly Thr Asp Gly Thr 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Leu Thr Ser Leu 
305                 310                 315                 320 


Leu Ala Cys Gly Asp Leu Gln Val Thr Gly Ser Gly His Cys Pro Tyr 
                325                 330                 335     


Ser Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 
            340                 345                 350         


Glu Gly Val Asn Gly Ile Glu Glu Arg Met Thr Val Val Trp Asp Lys 
        355                 360                 365             


Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Ile Ala Val Gly Ser Asp Ala Asp Val Val Ile Trp Asp Pro Asp Lys 
                405                 410                 415     


Leu Lys Thr Ile Thr Ala Lys Ser His Lys Ser Ala Val Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Met Glu Cys His Gly Ser Pro Leu Val Val Ile Ser 
        435                 440                 445             


Gln Gly Lys Ile Val Phe Glu Asp Gly Asn Ile Asn Val Asn Lys Gly 
    450                 455                 460                 


Met Gly Arg Phe Ile Pro Arg Lys Ala Phe Pro Glu His Leu Tyr Gln 
465                 470                 475                 480 


Arg Val Lys Ile Arg Asn Lys Val Phe Gly Leu Gln Gly Val Ser Arg 
                485                 490                 495     


Gly Met Tyr Asp Gly Pro Val Tyr Glu Val Pro Ala Thr Pro Lys Tyr 
            500                 505                 510         


Ala Thr Pro Ala Pro Ser Ala Lys Ser Ser Pro Ser Lys His Gln Pro 
        515                 520                 525             


Pro Pro Ile Arg Asn Leu His Gln Ser Asn Phe Ser Leu Ser Gly Ala 
    530                 535                 540                 


Gln Ile Asp Asp Asn Asn Pro Arg Arg Thr Gly His Arg Ile Val Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Gly 
                565                 570         


<210>  8
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met 
    50                  55                  60                  


Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp 
65                  70                  75                  80  


Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
            100                 105                 110         


Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp 
        115                 120                 125             


Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp 
    130                 135                 140                 


His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu 
                165                 170                 175     


Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly 
            180                 185                 190         


Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu 
        195                 200                 205             


Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile 
225                 230                 235                 240 


Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met 
                245                 250                 255     


Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr 
            260                 265                 270         


Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu 
305                 310                 315                 320 


Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys 
        355                 360                 365             


Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser 
                405                 410                 415     


Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser 
        435                 440                 445             


Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly 
    450                 455                 460                 


Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr 
            500                 505                 510         


Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala 
    530                 535                 540                 


Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly 
                565                 570         


<210>  9
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Lys Gly Gly Arg Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Asp Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly Lys Met 
    50                  55                  60                  


Val Ile Pro Gly Gly Ile Asp Val His Thr His Phe Gln Met Pro Tyr 
65                  70                  75                  80  


Lys Gly Met Thr Thr Val Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
            100                 105                 110         


Glu Ser Ser Leu Thr Glu Ala Tyr Glu Lys Trp Arg Glu Trp Ala Asp 
        115                 120                 125             


Gly Lys Ser Cys Cys Asp Tyr Ala Leu His Val Asp Ile Thr His Trp 
    130                 135                 140                 


Asn Asp Ser Val Lys Gln Glu Val Gln Asn Leu Ile Lys Asp Lys Gly 
145                 150                 155                 160 


Val Asn Ser Phe Met Val Tyr Met Ala Tyr Lys Asp Leu Tyr Gln Val 
                165                 170                 175     


Ser Asn Thr Glu Leu Tyr Glu Ile Phe Thr Cys Leu Gly Glu Leu Gly 
            180                 185                 190         


Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Gln Glu 
        195                 200                 205             


Gln Thr Arg Met Leu Glu Met Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg Ala Ile 
225                 230                 235                 240 


Thr Ile Ala Ser Gln Thr Asn Cys Pro Leu Tyr Val Thr Lys Val Met 
                245                 250                 255     


Ser Lys Ser Ala Ala Asp Leu Ile Ser Gln Ala Arg Lys Lys Gly Asn 
            260                 265                 270         


Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Ile Asp Gly Thr 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Ile Asn Ser Leu 
305                 310                 315                 320 


Leu Ala Ser Gly Asp Leu Gln Leu Ser Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Ser Thr Ala Gln Lys Ala Ile Gly Lys Asp Asn Phe Thr Ala Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Val Glu Glu Arg Met Ser Val Ile Trp Asp Lys 
        355                 360                 365             


Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Ile Ser Val Gly Ser Asp Ser Asp Leu Val Ile Trp Asp Pro Asp Ala 
                405                 410                 415     


Val Lys Ile Val Ser Ala Lys Asn His Gln Ser Ala Ala Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Met Glu Leu Arg Gly Ala Pro Leu Val Val Ile Cys 
        435                 440                 445             


Gln Gly Lys Ile Met Leu Glu Asp Gly Asn Leu His Val Thr Gln Gly 
    450                 455                 460                 


Ala Gly Arg Phe Ile Pro Cys Ser Pro Phe Ser Asp Tyr Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Arg Lys Met Ala Asp Leu His Ala Val Pro Arg 
                485                 490                 495     


Gly Met Tyr Asp Gly Pro Val Phe Asp Leu Thr Thr Thr Pro Lys Gly 
            500                 505                 510         


Gly Thr Pro Ala Gly Ser Ala Arg Gly Ser Pro Thr Arg Pro Asn Pro 
        515                 520                 525             


Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Thr Gln 
    530                 535                 540                 


Val Asp Glu Gly Val Arg Ser Ala Ser Lys Arg Ile Val Ala Pro Pro 
545                 550                 555                 560 


Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
                565                 570 


<210>  10
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Phe Gln Gly Lys Lys Ser Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Arg Gly Gly Arg Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Val His Val Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Ile Lys Thr Ile Asp Ala His Gly Leu Met 
    50                  55                  60                  


Val Leu Pro Gly Gly Val Asp Val His Thr Arg Leu Gln Met Pro Val 
65                  70                  75                  80  


Leu Gly Met Thr Pro Ala Asp Asp Phe Cys Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Leu Asp His Val Phe Pro Asp Thr 
            100                 105                 110         


Gly Val Ser Leu Leu Ala Ala Tyr Glu Gln Trp Arg Glu Arg Ala Asp 
        115                 120                 125             


Ser Ala Ala Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Arg Trp 
    130                 135                 140                 


His Glu Ser Ile Lys Glu Glu Leu Glu Ala Leu Val Lys Glu Lys Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Phe Met Ala Tyr Lys Asp Arg Cys Gln Cys 
                165                 170                 175     


Ser Asp Ser Gln Met Tyr Glu Ile Phe Ser Ile Ile Arg Asp Leu Gly 
            180                 185                 190         


Ala Leu Ala Gln Val His Ala Glu Asn Gly Asp Ile Val Glu Glu Glu 
        195                 200                 205             


Gln Lys Arg Leu Leu Glu Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser His Pro Glu Glu Val Glu Ala Glu Ala Val Tyr Arg Ala Val 
225                 230                 235                 240 


Thr Ile Ala Lys Gln Ala Asn Cys Pro Leu Tyr Val Thr Lys Val Met 
                245                 250                 255     


Ser Lys Gly Ala Ala Asp Ala Ile Ala Gln Ala Lys Arg Arg Gly Val 
            260                 265                 270         


Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Val Asn Pro Asp Pro Thr Thr Ala Asp His Leu Thr Cys Leu 
305                 310                 315                 320 


Leu Ser Ser Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Thr Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Ala Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Ile Glu Glu Arg Met Ser Met Val Trp Glu Lys 
        355                 360                 365             


Cys Val Ala Ser Gly Lys Met Asp Glu Asn Glu Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Ile Phe Asn Phe Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Val Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asn Pro Lys Ala 
                405                 410                 415     


Thr Lys Ile Ile Ser Ala Lys Thr His Asn Leu Asn Val Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Val Glu Cys Arg Gly Ala Pro Ala Val Val Ile Ser 
        435                 440                 445             


Gln Gly Arg Val Ala Leu Glu Asp Gly Lys Met Phe Val Thr Pro Gly 
    450                 455                 460                 


Ala Gly Arg Phe Val Pro Arg Lys Thr Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Asn Arg Leu Ala Glu Ile His Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val His Glu Val Met Val Pro Ala Lys Pro 
            500                 505                 510         


Gly Ser Gly Ala Pro Ala Arg Ala Ser Cys Pro Gly Lys Ile Ser Val 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ser 
    530                 535                 540                 


Gln Ala Asp Asp His Ile Ala Arg Arg Thr Ala Gln Lys Ile Met Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
                565                 570         


<210>  11
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Ala Asn Ser Ala Ser Val Arg Ile Leu Ile Lys Gly Gly Lys 
1               5                   10                  15      


Val Val Asn Asp Asp Cys Thr His Glu Ala Asp Val Tyr Ile Glu Asn 
            20                  25                  30          


Gly Ile Ile Gln Gln Val Gly Arg Glu Leu Met Ile Pro Gly Gly Ala 
        35                  40                  45              


Lys Val Ile Asp Ala Thr Gly Lys Leu Val Ile Pro Gly Gly Ile Asp 
    50                  55                  60                  


Thr Ser Thr His Phe His Gln Thr Phe Met Asn Ala Thr Cys Val Asp 
65                  70                  75                  80  


Asp Phe Tyr His Gly Thr Lys Ala Ala Leu Val Gly Gly Thr Thr Met 
                85                  90                  95      


Ile Ile Gly His Val Leu Pro Asp Lys Glu Thr Ser Leu Val Asp Ala 
            100                 105                 110         


Tyr Glu Lys Cys Arg Gly Leu Ala Asp Pro Lys Val Cys Cys Asp Tyr 
        115                 120                 125             


Ala Leu His Val Gly Ile Thr Trp Trp Ala Pro Lys Val Lys Ala Glu 
    130                 135                 140                 


Met Glu Thr Leu Val Arg Glu Lys Gly Val Asn Ser Phe Gln Met Phe 
145                 150                 155                 160 


Met Thr Tyr Lys Asp Leu Tyr Met Leu Arg Asp Ser Glu Leu Tyr Gln 
                165                 170                 175     


Val Leu His Ala Cys Lys Asp Ile Gly Ala Ile Ala Arg Val His Ala 
            180                 185                 190         


Glu Asn Gly Glu Leu Val Ala Glu Gly Ala Lys Glu Ala Leu Asp Leu 
        195                 200                 205             


Gly Ile Thr Gly Pro Glu Gly Ile Glu Ile Ser Arg Pro Glu Glu Leu 
    210                 215                 220                 


Glu Ala Glu Ala Thr His Arg Val Ile Thr Ile Ala Asn Arg Thr His 
225                 230                 235                 240 


Cys Pro Ile Tyr Leu Val Asn Val Ser Ser Ile Ser Ala Gly Asp Val 
                245                 250                 255     


Ile Ala Ala Ala Lys Met Gln Gly Lys Val Val Leu Ala Glu Thr Thr 
            260                 265                 270         


Thr Ala His Ala Thr Leu Thr Gly Leu His Tyr Tyr His Gln Asp Trp 
        275                 280                 285             


Ser His Ala Ala Ala Tyr Val Thr Val Pro Pro Leu Arg Leu Asp Thr 
    290                 295                 300                 


Asn Thr Ser Thr Tyr Leu Met Ser Leu Leu Ala Asn Asp Thr Leu Asn 
305                 310                 315                 320 


Ile Val Ala Ser Asp His Arg Pro Phe Thr Thr Lys Gln Lys Ala Met 
                325                 330                 335     


Gly Lys Glu Asp Phe Thr Lys Ile Pro His Gly Val Ser Gly Val Gln 
            340                 345                 350         


Asp Arg Met Ser Val Ile Trp Glu Arg Gly Val Val Gly Gly Lys Met 
        355                 360                 365             


Asp Glu Asn Arg Phe Val Ala Val Thr Ser Ser Asn Ala Ala Lys Leu 
    370                 375                 380                 


Leu Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ile Pro Gly Ala Asp Ala 
385                 390                 395                 400 


Asp Val Val Val Trp Asp Pro Glu Ala Thr Lys Thr Ile Ser Ala Ser 
                405                 410                 415     


Thr Gln Val Gln Gly Gly Asp Phe Asn Leu Tyr Glu Asn Met Arg Cys 
            420                 425                 430         


His Gly Val Pro Leu Val Thr Ile Ser Arg Gly Arg Val Val Tyr Glu 
        435                 440                 445             


Asn Gly Val Phe Met Cys Ala Glu Gly Thr Gly Lys Phe Cys Pro Leu 
    450                 455                 460                 


Arg Ser Phe Pro Asp Thr Val Tyr Lys Lys Leu Val Gln Arg Glu Lys 
465                 470                 475                 480 


Thr Leu Lys Val Arg Gly Val Asp Arg Thr Pro Tyr Leu Gly Asp Val 
                485                 490                 495     


Ala Val Val Val His Pro Gly Lys Lys Glu Met Gly Thr Pro Leu Ala 
            500                 505                 510         


Asp Thr Pro Thr Arg Pro Val Thr Arg His Gly Gly Met Arg Asp Leu 
        515                 520                 525             


His Glu Ser Ser Phe Ser Leu Ser Gly Ser Gln Ile Asp Asp His Val 
    530                 535                 540                 


Pro Lys Arg Ala Ser Ala Arg Ile Leu Ala Pro Pro Gly Gly Arg Ser 
545                 550                 555                 560 


Ser Gly Ile Trp 
                


<210>  12
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha 1A (Q71U36)

<400>  12

Tyr Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu 
1               5                   10                  15      


Gly Glu Glu Tyr 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha 1B (P68363)

<400>  13

Tyr Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu 
1               5                   10                  15      


Gly Glu Glu Tyr 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha 1C (Q9BQE3)

<400>  14

Lys Asp Tyr Glu Glu Val Gly Ala Asp Ser Ala Asp Gly Glu Asp Glu 
1               5                   10                  15      


Gly Glu Glu Tyr 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha 3C (Q13748)

<400>  15

Asp Tyr Glu Glu Val Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu 
1               5                   10                  15      


Gly Glu Glu Tyr 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha 3E (Q6PEY2)

<400>  16

Asp Cys Glu Glu Val Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu 
1               5                   10                  15      


Gly Glu Ala Tyr 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha 4A (P68366)

<400>  17

Glu Lys Asp Tyr Glu Glu Val Gly Ile Asp Ser Tyr Glu Asp Glu Asp 
1               5                   10                  15      


Glu Gly Glu Glu 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Alpha 8 (Q9NY65)

<400>  18

Lys Asp Tyr Glu Glu Val Gly Thr Asp Ser Phe Glu Glu Glu Asn Glu 
1               5                   10                  15      


Gly Glu Glu Phe 
            20  


<210>  19
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptidic based inhibitor

<400>  19

Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu Gly Glu Glu Tyr 
1               5                   10                  15  


<210>  20
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptidic moiety


<220>
<221>  peptidic
<222>  (1)..(16)
<223>  X1, X2, X5, X7, X9 and X13  = G, A or V

       X3, X6, X8, X10, X11, X12, X14 and X15 = E or D

       X4=S, T, N or Q

X16 = Y or F

<400>  20

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


