               SEQUENCE LISTING

<110> NBE Therapeutics

<120> multispecific antibody product that binds to different ROR1 epitopes 

<130> ND40645

<160> 98

<170> BiSSAP 1.3.6

<210> 1
<211> 377
<212> PRT
<213> Artificial Sequence


<220> 
<223> >hROR1 extracellular domain amino acid sequence
      [organism=Artificial Sequence]

<400> 1
Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      
Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          
Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              
His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys 
    50                  55                  60                  
Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser 
65                  70                  75                  80  
Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      
Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser 
            100                 105                 110         
Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             
Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 
Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 
Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     
Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         
Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             
Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 
Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 
Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     
Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         
Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             
Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 
Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala 
305                 310                 315                 320 
Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     
Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         
Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             
Glu Lys Asn Lys Met Glu Ile Leu Tyr 
    370                 375         

<210> 2
<211> 443
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324HC amino acid sequence [organism=Artificial Sequence]

<400> 2
Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Asn Gly 
            20                  25                  30          
Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Ile Ile Thr Ser Ser Gly Asp Lys Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  
Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      
Thr Val Ser Ser Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 3
<211> 219
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324LC amino acid sequence [organism=Artificial Sequence]

<400> 3
Glu Leu Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          
Asn Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Arg Ala Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asn Val 
65                  70                  75                  80  
Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Val Ser 
                85                  90                  95      
Gln Ser Tyr Arg Ala Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210> 4
<211> 448
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-301HC amino acid sequence [organism=Artificial Sequence]

<400> 4
Gln Glu Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Thr Tyr 
            20                  25                  30          
His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ser Ile Tyr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asn Thr Thr Gln Asn Thr Val Ser 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp His Pro Ser Tyr Gly Met Asp Leu Trp Gly Pro Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             



<210> 5
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-301LC amino acid sequence [organism=Artificial Sequence]

<400> 5
Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Ser Ile Gly Ser Lys Ala Val 
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              
Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Ala Ser 
    50                  55                  60                  
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Leu Trp Asp Ser Ser Ala Val Ala 
                85                  90                  95      
Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gln Pro Lys 
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             
Ala Pro Thr Glu Cys Ser 
    210                 

<210> 6
<211> 455
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-306HC amino acid sequence [organism=Artificial Sequence]

<400> 6
Gln Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Phe Asp Leu Ser Asn Tyr 
            20                  25                  30          
Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Ile Asp Pro Thr Phe Asp Tyr Thr Tyr Tyr Ala Ser Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Ser Ile Ser Arg Glu Asn Thr Gln Asn Thr Val Ser 
65                  70                  75                  80  
Leu Gln Ile Asn Ser Leu Thr Pro Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Trp Val Tyr Gly Val Asp Asp Tyr Gly Asp Gly Asn Trp Leu 
            100                 105                 110         
Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Ile Ser Ser Ala Ser Thr 
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys 
    450                 455 

<210> 7
<211> 217
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-306LC amino acid sequence [organism=Artificial Sequence]

<400> 7
Gln Phe Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ala 
1               5                   10                  15      
Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          
Ile Asp Trp Tyr Gln Gln Gln Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              
Glu Leu Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  
Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Asp Tyr 
                85                  90                  95      
Ser Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 
Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         
His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             
Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         

<210> 8
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 HC amino acid sequence [organism=Artificial Sequence]

<400> 8
Gln Glu Gln Gln Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Asp Ile Ser Ser Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Gly Ile Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Ser Arg Ser Thr Ile Thr Arg Asn Thr Asn Leu Asn Thr Val Thr Leu 
65                  70                  75                  80  
Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      
Arg Asp His Pro Thr Tyr Gly Met Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 9
<211> 212
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 LC amino acid sequence [organism=Artificial Sequence]

<400> 9
Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ala Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              
Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ala Tyr Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gln Pro Lys Ala Ala 
            100                 105                 110         
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser 
            180                 185                 190         
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             
Thr Glu Cys Ser 
    210         

<210> 10
<211> 446
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-403HC amino acid sequence [organism=Artificial Sequence]

<400> 10
Gln Glu Gln Leu Lys Glu Ser Gly Arg Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Gly Trp 
            20                  25                  30          
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Thr Ile Gly Thr Thr Lys Gly Arg Thr Tyr Tyr Ala Ser Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Val Arg Gly Ser Asp Tyr Phe Asp Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Ile Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210> 11
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-403LC amino acid sequence [organism=Artificial Sequence]

<400> 11
Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Ser Ile Gly Ser Lys Ala Val 
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              
Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Leu Trp Asp Ser Ser Ala Gly Ala 
                85                  90                  95      
Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gln Pro Lys 
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             
Ala Pro Thr Glu Cys Ser 
    210                 

<210> 12
<211> 444
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Top43HC amino acid sequence [organism=Artificial Sequence]

<400> 12
Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Trp 
            20                  25                  30          
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Ala Ile Tyr Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Val 
                85                  90                  95      
His Ser Thr Ala Thr Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Ile 
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210> 13
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Top43LC amino acid sequence [organism=Artificial Sequence]

<400> 13
Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ala Val 
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              
Asn Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Leu Trp Asp Ser Ser Ala Gly Ala 
                85                  90                  95      
Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gln Pro Lys 
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             
Ala Pro Thr Glu Cys Ser 
    210                 

<210> 14
<211> 470
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 scFv HC & LC amino acid sequence [organism=Artificial
      Sequence]

<400> 14
Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ala Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              
Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ala Tyr Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gly Gly Gly Ser Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Glu Gln Gln Lys Glu Ser 
        115                 120                 125             
Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr 
    130                 135                 140                 
Ala Ser Gly Phe Asp Ile Ser Ser Tyr Tyr Met Ser Trp Val Arg Gln 
145                 150                 155                 160 
Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly Ala Ile Gly Ile Ser Gly 
                165                 170                 175     
Asn Ala Tyr Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg 
            180                 185                 190         
Asn Thr Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala 
        195                 200                 205             
Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp His Pro Thr Tyr Gly 
    210                 215                 220                 
Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 
Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 
Ser Leu Ser Pro Gly Lys 
465                 470 

<210> 15
<211> 472
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324-scFv HC & LC amino acid sequence [organism=Artificial
      Sequence]

<400> 15
Glu Leu Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          
Asn Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Arg Ala Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asn Val 
65                  70                  75                  80  
Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Val Ser 
                85                  90                  95      
Gln Ser Tyr Arg Ala Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             
Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser Leu 
    130                 135                 140                 
Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Asn Gly Met 
145                 150                 155                 160 
Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile 
                165                 170                 175     
Ile Thr Ser Ser Gly Asp Lys Tyr Tyr Ala Thr Trp Ala Lys Gly Arg 
            180                 185                 190         
Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met Thr 
        195                 200                 205             
Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Thr 
    210                 215                 220                 
Val Ser Ser Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser 
225                 230                 235                 240 
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         

<210> 16
<211> 470
<212> PRT
<213> Artificial Sequence


<220> 
<223> >scFv-402-Fc-KIH-p1 (Knob) [organism=Artificial Sequence]

<400> 16
Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ala Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              
Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ala Tyr Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gly Gly Gly Ser Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Glu Gln Gln Lys Glu Ser 
        115                 120                 125             
Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr 
    130                 135                 140                 
Ala Ser Gly Phe Asp Ile Ser Ser Tyr Tyr Met Ser Trp Val Arg Gln 
145                 150                 155                 160 
Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly Ala Ile Gly Ile Ser Gly 
                165                 170                 175     
Asn Ala Tyr Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg 
            180                 185                 190         
Asn Thr Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala 
        195                 200                 205             
Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp His Pro Thr Tyr Gly 
    210                 215                 220                 
Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 
Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 
Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys 
            420                 425                 430         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 
Ser Leu Ser Pro Gly Lys 
465                 470 

<210> 17
<211> 472
<212> PRT
<213> Artificial Sequence


<220> 
<223> >scFv-ERR1-324-Fc-KIH-p2 (Hole) [organism=Artificial Sequence]

<400> 17
Glu Leu Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          
Asn Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Arg Ala Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asn Val 
65                  70                  75                  80  
Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Val Ser 
                85                  90                  95      
Gln Ser Tyr Arg Ala Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             
Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser Leu 
    130                 135                 140                 
Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Asn Gly Met 
145                 150                 155                 160 
Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile 
                165                 170                 175     
Ile Thr Ser Ser Gly Asp Lys Tyr Tyr Ala Thr Trp Ala Lys Gly Arg 
            180                 185                 190         
Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met Thr 
        195                 200                 205             
Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Thr 
    210                 215                 220                 
Val Ser Ser Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser 
225                 230                 235                 240 
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 
Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         

<210> 18
<211> 577
<212> PRT
<213> Artificial Sequence


<220> 
<223> >324-LL-R12 HC amino acid sequence [organism=Artificial Sequence]

<400> 18
Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Asn Gly 
            20                  25                  30          
Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Ile Ile Thr Ser Ser Gly Asp Lys Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  
Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      
Thr Val Ser Ser Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Gln Glu 
        115                 120                 125             
Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser Leu 
    130                 135                 140                 
Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr Tyr Met 
145                 150                 155                 160 
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Thr 
                165                 170                 175     
Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val Asn Gly 
            180                 185                 190         
Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp Leu Gln 
        195                 200                 205             
Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys Ala Arg 
    210                 215                 220                 
Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly Pro Gly 
225                 230                 235                 240 
Thr Leu Val Thr Ile Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                245                 250                 255     
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            260                 265                 270         
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        275                 280                 285             
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    290                 295                 300                 
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
305                 310                 315                 320 
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                325                 330                 335     
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
            340                 345                 350         
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                485                 490                 495     
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     
Lys 
    

<210> 19
<211> 342
<212> PRT
<213> Artificial Sequence


<220> 
<223> >324-LL-R12 LC amino acid sequence [organism=Artificial Sequence]

<400> 19
Glu Leu Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          
Asn Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Arg Ala Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asn Val 
65                  70                  75                  80  
Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Val Ser 
                85                  90                  95      
Gln Ser Tyr Arg Ala Ala Phe Gly Gly Gly Thr Glu Leu Glu Ile Leu 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Glu Leu Val 
        115                 120                 125             
Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys 
    130                 135                 140                 
Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp 
145                 150                 155                 160 
Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln 
                165                 170                 175     
Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         
Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln 
        195                 200                 205             
Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly 
    210                 215                 220                 
Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gln Pro Lys 
225                 230                 235                 240 
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
                245                 250                 255     
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
            260                 265                 270         
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
        275                 280                 285             
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
    290                 295                 300                 
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
305                 310                 315                 320 
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
                325                 330                 335     
Ala Pro Thr Glu Cys Ser 
            340         

<210> 20
<211> 451
<212> PRT
<213> Artificial Sequence


<220> 
<223> >R12 HC amino acid sequence [organism=Artificial Sequence]

<400> 20
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 21
<211> 217
<212> PRT
<213> Artificial Sequence


<220> 
<223> >R12 LC amino acid sequence [organism=Artificial Sequence]

<400> 21
Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser 
1               5                   10                  15      
Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr 
            20                  25                  30          
Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              
Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  
Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr 
                85                  90                  95      
Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 
Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         
His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             
Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         

<210> 22
<211> 448
<212> PRT
<213> Artificial Sequence


<220> 
<223> >2A2 HC amino acid sequence [organism=Artificial Sequence]

<400> 22
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             



<210> 23
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >2A2 LC amino acid sequence [organism=Artificial Sequence]

<400> 23
Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser Thr Thr Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ala Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 24
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Ac10 HC amino acid sequence [organism=Artificial Sequence]

<400> 24
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         
Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 25
<211> 218
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Ac10 LC amino acid sequence [organism=Artificial Sequence]

<400> 25
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Val Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      
Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 26
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> >pCEP4-hROR1-F [organism=Artificial Sequence]

<400> 26
atcctgtttc tcgtagctgc tgcaactgga gcacactccg cccggggcgc cgccgcccag     60


<210> 27
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> >pCEP4-hROR1- Avi-tag-R [organism=Artificial Sequence]

<400> 27
ccactcgatc ttctgggcct cgaagatgtc gttcaggccc tccatcttgt tcttctcctt     60


<210> 28
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> >pCEP4-signal-F-KpnI [organism=Artificial Sequence]

<400> 28
gctgggtacc ggcgcgccac catggactgg acttggagaa tcctgtttct cgtagctgct     60


<210> 29
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> >pCEP4-6HIS-R-XhoI [organism=Artificial Sequence]

<400> 29
gccggcctcg agtcagtgat ggtgatggtg gtgctcgtgc cactcgatct tctgggcctc     60


<210> 30
<211> 52
<212> DNA
<213> Artificial Sequence


<220> 
<223> >hROR1-His_R [organism=Artificial Sequence]

<400> 30
cggcctcgag tcagtgatgg tgatggtggt gctccatctt gttcttctcc tt             52


<210> 31
<211> 99
<212> DNA
<213> Artificial Sequence


<220> 
<223> >SP-hROR2_F [organism=Artificial Sequence]

<400> 31
gctgggtacc ggcgcgccac catggactgg acttggagaa tcctgtttct cgtagctgct     60

gcaactggag cacactccga agtggaggtt ctggatccg                            99


<210> 32
<211> 52
<212> DNA
<213> Artificial Sequence


<220> 
<223> >hROR2-His_R [organism=Artificial Sequence]

<400> 32
cggcctcgag tcagtgatgg tgatggtggt gccccatctt gctgctgtct cg             52


<210> 33
<211> 41
<212> DNA
<213> Artificial Sequence


<220> 
<223> >XBR1-402_VH_F [organism=Artificial Sequence]

<400> 33
gaggaggagc tcactctcag gagcagcaga aggagtccgg g                         41


<210> 34
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> >XBR1-402_VH_R [organism=Artificial Sequence]

<400> 34
cgatgggccc ttggtggagg ctgaagagac ggtgacgagg gtccctggcc cccagaggtc     60


<210> 35
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> >XBR1-402_?_F [organism=Artificial Sequence]

<400> 35
gagaagcttg ttgctctgga tctctggtgc ctacgggtcc tatgagctga cacagctgcc     60


<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> >LEAD-B [organism=Artificial Sequence]

<400> 36
ggccatggct ggttgggcag c                                              21


<210> 37
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> >KpnI_AscI-Signal [organism=Artificial Sequence]

<400> 37
ggtaccggcg cgccaccatg gactggactt ggagaatcct gtttctcgta gctgctgcaa     60


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> >CH1-internal_overlap-R [organism=Artificial Sequence]

<400> 38
gccgctggtc agggctcctg                                                20


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> >CH1-internal_overlap-F [organism=Artificial Sequence]

<400> 39
caggagccct gaccagcggc                                                20


<210> 40
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> >HC-CH3-R-XhoI [organism=Artificial Sequence]

<400> 40
ggcctcgagt catttacccg gagacaggga                                     30


<210> 41
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> >ERR1-324 HC-F [organism=Artificial Sequence]

<400> 41
tttctcgtag ctgctgcaac tggagcacac tcccagtcgc tggaggagtc cggg           54


<210> 42
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> >ERR1-TOP43 HC-F [organism=Artificial Sequence]

<400> 42
tttctcgtag ctgctgcaac tggagcacac tcccagtcgt tggaggagtc cggg           54


<210> 43
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> >ERR1-TOP54 HC-F [organism=Artificial Sequence]

<400> 43
tttctcgtag ctgctgcaac tggagcacac tcccagtcgt tggaggagtc cggg           54


<210> 44
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> >VH-CH1-R-EheI [organism=Artificial Sequence]

<400> 44
ggagggcgcc agggggaaga ccgatgggcc cttggt                               36


<210> 45
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> >ERR1-TOP43 LC-F [organism=Artificial Sequence]

<400> 45
tttctcgtag ctgctgcaac tggagcacac tcctcctatg agctgacaca gctg           54


<210> 46
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> >ERR1-TOP54 LC-F [organism=Artificial Sequence]

<400> 46
tttctcgtag ctgctgcaac tggagcacac tcctcctatg agctgacaca gctg           54


<210> 47
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> >ERR1-324 KC-F [organism=Artificial Sequence]

<400> 47
tttctcgtag ctgctgcaac tggagcacac tccgagctcg tgctgaccca gact           54


<210> 48
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> >LC-R-XhoI [organism=Artificial Sequence]

<400> 48
ggcctcgagt tatgaacatt ctgtaggggc                                     30


<210> 49
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> >KC-R-XhoI [organism=Artificial Sequence]

<400> 49
ggcctcgagt taacactctc ccctgttgaa                                     30


<210> 50
<211> 99
<212> DNA
<213> Artificial Sequence


<220> 
<223> >SP-hROR1_F [organism=Artificial Sequence]

<400> 50
gctgggtacc ggcgcgccac catggactgg acttggagaa tcctgtttct cgtagctgct     60

gcaactggag cacactccgc ccggggcgcc gccgcccag                            99


<210> 51
<211> 450
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Trastuzumab HC amino acid sequence [organism=Artificial
      Sequence]

<400> 51
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Lys 
    450 

<210> 52
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Trastuzumab LC amino acid sequence [organism=Artificial
      Sequence]

<400> 52
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 53
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Staphylococcus aureus sortase A recognition sequence, with X
      being any amino acid [organism=Artificial Sequence]

<400> 53
Leu Pro Xaa Thr Gly 
1               5   

<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Staphylococcus aureus sortase A recognition sequence, with X
      being any amino acid [organism=Artificial Sequence]

<400> 54
Leu Pro Xaa Ala Gly 
1               5   

<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >recognition sequence for Staphylococcus aureus sortase A or
      engineered sortase A 4S-9 from Staphylococcus aureus, with X
      being any amino acid [organism=Artificial Sequence]

<400> 55
Leu Pro Xaa Ser Gly 
1               5   

<210> 56
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >recognition sequence for engineered sortase A 2A-9 from
      Staphylococcus aureus, with X being any amino acid
      [organism=Artificial Sequence]

<400> 56
Leu Ala Xaa Thr Gly 
1               5   

<210> 57
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Streptococcus pyogenes sortase A recognition sequence, with X
      being any amino acid [organism=Artificial Sequence]

<400> 57
Leu Pro Xaa Thr Ala 
1               5   

<210> 58
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Staphylococcus aureus sortase recognition sequence
      [organism=Artificial Sequence]

<400> 58
Asn Pro Gln Thr Asn 
1               5   

<210> 59
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Linker derived from Staphylococcus aureus sortase A recognition
      sequence, with X being any amino acid and n ? 1 and ? 21
      [organism=Artificial Sequence]

<400> 59
Leu Pro Xaa Thr Gly 
1               5   

<210> 60
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Linker derived from Staphylococcus aureus sortase A recognition
      sequence, with X being any amino acid and n ? 1 and ? 21
      [organism=Artificial Sequence]

<400> 60
Leu Pro Xaa Ala Gly 
1               5   

<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Linker derived from recognition sequence for Staphylococcus
      aureus sortase A or engineered sortase A 4S-9 from Staphylococcus
      aureus, with X being any amino acid and n ? 1 and ? 21
      [organism=Artificial Sequence]

<400> 61
Leu Pro Xaa Ser Gly 
1               5   

<210> 62
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Linker derived from recognition sequence for engineered sortase
      A 2A-9 from Staphylococcus aureus, with X being any amino acid
      and n ? 1 and ? 21 [organism=Artificial Sequence]

<400> 62
Leu Ala Xaa Thr Gly 
1               5   

<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Linker derived from Streptococcus pyogenes sortase A recognition
      sequence, with X being any amino acid and n ? 1 and ? 21
      [organism=Artificial Sequence]

<400> 63
Leu Pro Xaa Thr Leu Pro Xaa Thr 
1               5               

<210> 64
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Linker derived from Staphylococcus aureus sortase recognition
      sequence, with n ? 1 and ? 21 [organism=Artificial Sequence]

<400> 64
Asn Pro Gln Thr Gly 
1               5   

<210> 65
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> >signal sequence [organism=Artificial Sequence]

<400> 65
Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys 
            

<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> >strepII-tag [organism=Artificial Sequence]

<400> 66
Trp Ser His Pro Gln Phe Glu Lys 
1               5               

<210> 67
<211> 712
<212> PRT
<213> Artificial Sequence


<220> 
<223> >scFv-Ig_324_4-2 HC sequence [organism=Artificial Sequence]

<400> 67
Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu Ser 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Asn Gly 
            20                  25                  30          
Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Ile Ile Thr Ser Ser Gly Asp Lys Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  
Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      
Thr Val Ser Ser Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser 
            100                 105                 110         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Thr Pro Ser Pro Val 
    130                 135                 140                 
Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln 
145                 150                 155                 160 
Ser Val Tyr Gly Asn Asn Glu Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     
Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Ile Leu Thr Ser Gly 
            180                 185                 190         
Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
        195                 200                 205             
Thr Ile Ser Asn Val Gln Arg Glu Asp Ala Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 
Gly Gly Tyr Val Ser Gln Ser Tyr Arg Ala Ala Phe Gly Gly Gly Thr 
225                 230                 235                 240 
Glu Leu Glu Ile Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     
Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Glu Gln Gln Lys Glu Ser 
            260                 265                 270         
Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr 
        275                 280                 285             
Ala Ser Gly Phe Asp Ile Ser Ser Tyr Tyr Met Ser Trp Val Arg Gln 
    290                 295                 300                 
Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly Ala Ile Gly Ile Ser Gly 
305                 310                 315                 320 
Asn Ala Tyr Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg 
                325                 330                 335     
Asn Thr Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala 
            340                 345                 350         
Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp His Pro Thr Tyr Gly 
        355                 360                 365             
Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    370                 375                 380                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
385                 390                 395                 400 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                405                 410                 415     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            420                 425                 430         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        435                 440                 445             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    450                 455                 460                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
465                 470                 475                 480 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                485                 490                 495     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            500                 505                 510         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        515                 520                 525             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    530                 535                 540                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
545                 550                 555                 560 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                565                 570                 575     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            580                 585                 590         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        595                 600                 605             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    610                 615                 620                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
625                 630                 635                 640 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                645                 650                 655     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            660                 665                 670         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        675                 680                 685             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    690                 695                 700                 
Ser Leu Ser Leu Ser Pro Gly Arg 
705                 710         

<210> 68
<211> 212
<212> PRT
<213> Artificial Sequence


<220> 
<223> >scFv-Ig_324_4-2 LC sequence [organism=Artificial Sequence]

<400> 68
Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Glu Gly Asn Asn Ile Gly Ser Lys Ala Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Gly Leu Leu Ile Tyr 
        35                  40                  45              
Asp Asp Asp Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ala Tyr Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Gln Pro Lys Ala Ala 
            100                 105                 110         
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser 
            180                 185                 190         
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             
Thr Glu Cys Ser 
    210         

<210> 69
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324 VL CDR1 [organism=Artificial Sequence]

<400> 69
Gln Ala Ser Gln Ser Val Tyr Gly Asn Asn Glu Leu Ala 
1               5                   10              

<210> 70
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324 VL CDR2 [organism=Artificial Sequence]

<400> 70
Arg Ala Ser Ile Leu Thr Ser 
1               5           

<210> 71
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324 VL CDR3 [organism=Artificial Sequence]

<400> 71
Leu Gly Gly Tyr Val Ser Gln Ser Tyr Arg Ala Ala 
1               5                   10          

<210> 72
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324 VH CDR1 [organism=Artificial Sequence]

<400> 72
Arg Asn Gly Met Thr 
1               5   

<210> 73
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324 VH CDR2 [organism=Artificial Sequence]

<400> 73
Ile Ile Thr Ser Ser Gly Asp Lys Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      



<210> 74
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >ERR1-324 VH CDR3 [organism=Artificial Sequence]

<400> 74
Gly Thr Val Ser Ser Asp Ile 
1               5           

<210> 75
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >2A2 VH CDR1

<400> 75
Gly Tyr Thr Phe Ser Asp Tyr Glu Met His 
1               5                   10  

<210> 76
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> >2A2 VH CDR2

<400> 76
Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> >2A2 VH CDR3

<400> 77
Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr 
1               5                   

<210> 78
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >2A2 VL CDR1

<400> 78
Lys Ala Ser Gln Asn Val Asp Ala Ala Val Ala 
1               5                   10      

<210> 79
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >2A2 VL CDR2

<400> 79
Ser Ala Ser Asn Arg Tyr Thr 
1               5           

<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> >2A2 VL CDR3

<400> 80
Gln Gln Tyr Asp Ile Tyr Pro Tyr Thr 
1               5                   

<210> 81
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 VH CDR1

<400> 81
Ser Tyr Tyr Met Ser 
1               5   

<210> 82
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 VH CDR2

<400> 82
Ala Ile Gly Ile Ser Gly Asn Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      



<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 VH CDR3

<400> 83
Asp His Pro Thr Tyr Gly Met Asp Leu 
1               5                   

<210> 84
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 VL CDR1

<400> 84
Glu Gly Asn Asn Ile Gly Ser Lys Ala Val His 
1               5                   10      

<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 VL CDR2

<400> 85
Asp Asp Asp Glu Arg Pro Ser 
1               5           

<210> 86
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> >XBR1-402 VL CDR3

<400> 86
Gln Val Trp Asp Ser Ser Ala Tyr Val 
1               5                   

<210> 87
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >R12 VH CDR1

<400> 87
Ala Tyr Tyr Met Ser 
1               5   

<210> 88
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> >R12 VH CDR2

<400> 88
Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val Asn 
1               5                   10                  15      
Gly 
    

<210> 89
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >R12 VH CDR3

<400> 89
Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile 
1               5                   10          

<210> 90
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >R12 VL CDR1

<400> 90
Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp 
1               5                   10          

<210> 91
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >R12 VL CDR2

<400> 91
Gly Ser Tyr Thr Lys Arg Pro 
1               5           

<210> 92
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> >R12 VL CDR3

<400> 92
Gly Ala Asp Tyr Ile Gly Gly Tyr Val 
1               5                   

<210> 93
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> >TOP43 VH CDR1

<400> 93
Ser Tyr Trp Met Ser 
1               5   

<210> 94
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> >TOP43 VH CDR2

<400> 94
Ala Ile Tyr Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      



<210> 95
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> >TOP43 VH CDR3

<400> 95
Asp Val His Ser Thr Ala Thr Asp Leu 
1               5                   

<210> 96
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >TOP43 VL CDR1

<400> 96
Gly Gly Asn Asn Ile Gly Ser Lys Ala Val Asn 
1               5                   10      

<210> 97
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> >TOP43 VL CDR2

<400> 97
Asn Asp Asp Glu Arg Pro Ser 
1               5           

<210> 98
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >TOP43 VL CDR3

<400> 98
Gln Leu Trp Asp Ser Ser Ala Gly Ala Tyr Val 
1               5                   10      

