               SEQUENCE LISTING

<110> INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
      UNIVERSITE D'EVRY VAL D'ESSONNE

<120> METHODS AND TOOLS FOR PURIFYING NUCLEIC ACIDS USING POLYMERIZED TUBULIN

<130> PR81310

<150> EP17306008
<151> 2017-07-27

<160> 14

<170> BiSSAP 1.3.6

<210> 1
<211> 250
<212> PRT
<213> Homo sapiens


<400> 1
Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala 
1               5                   10                  15      
Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro 
            20                  25                  30          
Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser 
        35                  40                  45              
Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser 
    50                  55                  60                  
Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg 
65                  70                  75                  80  
Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala 
                85                  90                  95      
Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser 
            100                 105                 110         
Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile 
        115                 120                 125             
Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys 
    130                 135                 140                 
Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr 
145                 150                 155                 160 
Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly 
                165                 170                 175     
Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu 
            180                 185                 190         
Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp 
        195                 200                 205             
Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His 
    210                 215                 220                 
Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
225                 230                 235                 240 
Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
                245                 250 

<210> 2
<211> 358
<212> PRT
<213> Homo sapiens


<400> 2
Gln Asn Lys Ile Leu Glu Gly Leu Glu Lys Leu Arg His Leu Asp Phe 
1               5                   10                  15      
Leu Arg Tyr Pro Val Ala Thr Gln Lys Asp Leu Ala Ser Gly Ala Val 
            20                  25                  30          
Pro Thr Asn Leu Lys Pro Ser Lys Ile Lys Gln Arg Ala Asp Ser Lys 
        35                  40                  45              
Glu Ser Leu Lys Ala Thr Thr Lys Thr Ala Val Ser Lys Leu Ala Lys 
    50                  55                  60                  
Arg Glu Glu Val Val Glu Glu Gly Ala Lys Glu Ala Arg Ser Glu Leu 
65                  70                  75                  80  
Ala Lys Glu Leu Ala Lys Thr Glu Lys Lys Ala Lys Glu Ser Ser Glu 
                85                  90                  95      
Lys Pro Pro Glu Lys Pro Ala Lys Pro Glu Arg Val Lys Thr Glu Ser 
            100                 105                 110         
Ser Glu Ala Leu Lys Ala Glu Lys Arg Lys Leu Ile Lys Asp Lys Val 
        115                 120                 125             
Gly Lys Lys His Leu Lys Glu Lys Ile Ser Lys Leu Glu Glu Lys Lys 
    130                 135                 140                 
Asp Lys Glu Lys Lys Glu Ile Lys Lys Glu Arg Lys Glu Leu Lys Lys 
145                 150                 155                 160 
Asp Glu Gly Arg Lys Glu Glu Lys Lys Asp Ala Lys Lys Glu Glu Lys 
                165                 170                 175     
Arg Lys Asp Thr Lys Pro Glu Leu Lys Lys Ile Ser Lys Pro Asp Leu 
            180                 185                 190         
Lys Pro Phe Thr Pro Glu Val Arg Lys Thr Leu Tyr Lys Ala Lys Val 
        195                 200                 205             
Pro Gly Arg Val Lys Ile Asp Arg Ser Arg Ala Ile Arg Gly Glu Lys 
    210                 215                 220                 
Glu Leu Ser Ser Glu Pro Gln Thr Pro Pro Ala Gln Lys Gly Thr Val 
225                 230                 235                 240 
Pro Leu Pro Thr Ile Ser Gly His Arg Glu Leu Val Leu Ser Ser Pro 
                245                 250                 255     
Glu Asp Leu Thr Gln Asp Phe Glu Glu Met Lys Arg Glu Glu Arg Ala 
            260                 265                 270         
Leu Leu Ala Glu Gln Arg Asp Thr Gly Leu Gly Asp Lys Pro Phe Pro 
        275                 280                 285             
Leu Asp Thr Ala Glu Glu Gly Pro Pro Ser Thr Ala Ile Gln Gly Thr 
    290                 295                 300                 
Pro Pro Ser Val Pro Gly Leu Gly Gln Glu Glu His Val Met Lys Glu 
305                 310                 315                 320 
Lys Glu Leu Val Pro Glu Val Pro Glu Glu Gln Gly Ser Lys Asp Arg 
                325                 330                 335     
Gly Leu Asp Ser Gly Ala Glu Thr Glu Glu Glu Lys Asp Thr Trp Glu 
            340                 345                 350         
Glu Lys Lys Gln Arg Glu 
        355             

<210> 3
<211> 308
<212> PRT
<213> Homo sapiens


<400> 3
Phe Lys Gln Ala Lys Asp Lys Val Ser Asp Gly Val Thr Lys Ser Pro 
1               5                   10                  15      
Glu Lys Arg Ser Ser Leu Pro Arg Pro Ser Ser Ile Leu Pro Pro Arg 
            20                  25                  30          
Arg Gly Val Ser Gly Asp Arg Asp Glu Asn Ser Phe Ser Leu Asn Ser 
        35                  40                  45              
Ser Ile Ser Ser Ser Ala Arg Arg Thr Thr Arg Ser Glu Pro Ile Arg 
    50                  55                  60                  
Arg Ala Gly Lys Ser Gly Thr Ser Thr Pro Thr Thr Pro Gly Ser Thr 
65                  70                  75                  80  
Ala Ile Thr Pro Gly Thr Pro Pro Ser Tyr Ser Ser Arg Thr Pro Gly 
                85                  90                  95      
Thr Pro Gly Thr Pro Ser Tyr Pro Arg Thr Pro His Thr Pro Gly Thr 
            100                 105                 110         
Pro Lys Ser Ala Ile Leu Val Pro Ser Glu Lys Lys Val Ala Ile Ile 
        115                 120                 125             
Arg Thr Pro Pro Lys Ser Pro Ala Thr Pro Lys Gln Leu Arg Leu Ile 
    130                 135                 140                 
Asn Gln Pro Leu Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser 
145                 150                 155                 160 
Thr Asp Asn Ile Lys Tyr Gln Pro Lys Gly Gly Gln Val Gln Ile Val 
                165                 170                 175     
Thr Lys Lys Ile Asp Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu 
            180                 185                 190         
Lys Asn Ile Arg His Arg Pro Gly Gly Gly Arg Val Lys Ile Glu Ser 
        195                 200                 205             
Val Lys Leu Asp Phe Lys Glu Lys Ala Gln Ala Lys Val Gly Ser Leu 
    210                 215                 220                 
Asp Asn Ala His His Val Pro Gly Gly Gly Asn Val Lys Ile Asp Ser 
225                 230                 235                 240 
Gln Lys Leu Asn Phe Arg Glu His Ala Lys Ala Arg Val Asp His Gly 
                245                 250                 255     
Ala Glu Ile Ile Thr Gln Ser Pro Gly Arg Ser Ser Val Ala Ser Pro 
            260                 265                 270         
Arg Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Leu Leu Glu 
        275                 280                 285             
Ser Pro Gln Leu Ala Thr Leu Ala Glu Asp Val Thr Ala Ala Leu Ala 
    290                 295                 300                 
Lys Gln Gly Leu 
305             

<210> 4
<211> 162
<212> PRT
<213> Homo sapiens


<400> 4
Leu Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys Asn Val Arg Ser Lys 
1               5                   10                  15      
Val Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Arg Ala 
            20                  25                  30          
Lys Val Glu Lys Lys Thr Glu Ala Ala Ala Thr Thr Arg Lys Pro Glu 
        35                  40                  45              
Ser Asn Ala Val Thr Lys Thr Ala Gly Pro Ile Ala Ser Ala Gln Lys 
    50                  55                  60                  
Gln Pro Ala Gly Lys Val Gln Ile Val Ser Lys Lys Val Ser Tyr Ser 
65                  70                  75                  80  
His Ile Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
                85                  90                  95      
Gly Gly Gly Asn Val Gln Ile Gln Asn Lys Lys Val Asp Ile Ser Lys 
            100                 105                 110         
Val Ser Ser Lys Cys Gly Ser Lys Ala Asn Ile Lys His Lys Pro Gly 
        115                 120                 125             
Gly Gly Asp Val Lys Ile Glu Ser Gln Lys Leu Asn Phe Lys Glu Lys 
    130                 135                 140                 
Ala Gln Ala Lys Val Gly Ser Leu Asp Asn Val Gly His Leu Pro Ala 
145                 150                 155                 160 
Gly Gly 
        

<210> 5
<211> 203
<212> PRT
<213> Homo sapiens


<400> 5
Ser Val Met Arg Gln Asp Tyr Arg Ala Trp Lys Val Gln Arg Pro Glu 
1               5                   10                  15      
Pro Ser Cys Arg Pro Arg Ser Glu Tyr Gln Pro Ser Asp Ala Pro Phe 
            20                  25                  30          
Glu Arg Glu Thr Gln Tyr Gln Lys Asp Phe Arg Ala Trp Pro Leu Pro 
        35                  40                  45              
Arg Arg Gly Asp His Pro Trp Ile Pro Lys Pro Val Gln Ile Ser Ala 
    50                  55                  60                  
Ala Ser Gln Ala Ser Ala Pro Ile Leu Gly Ala Pro Lys Arg Arg Pro 
65                  70                  75                  80  
Gln Ser Gln Glu Arg Trp Pro Val Gln Ala Ala Ala Glu Ala Arg Glu 
                85                  90                  95      
Gln Glu Ala Ala Pro Gly Gly Ala Gly Gly Leu Ala Ala Gly Lys Ala 
            100                 105                 110         
Ser Gly Ala Asp Glu Arg Asp Thr Arg Arg Lys Ala Gly Pro Ala Trp 
        115                 120                 125             
Ile Val Arg Arg Ala Glu Gly Leu Gly His Glu Gln Thr Pro Leu Pro 
    130                 135                 140                 
Ala Ala Gln Ala Gln Val Gln Ala Thr Gly Pro Glu Ala Gly Arg Gly 
145                 150                 155                 160 
Arg Ala Ala Ala Asp Ala Leu Asn Arg Gln Ile Arg Glu Glu Val Ala 
                165                 170                 175     
Ser Ala Val Ser Ser Ser Tyr Arg Asn Glu Phe Arg Ala Trp Thr Asp 
            180                 185                 190         
Ile Lys Pro Val Lys Pro Ile Lys Ala Lys Pro 
        195                 200             

<210> 6
<211> 145
<212> PRT
<213> Homo sapiens


<400> 6
Tyr Asp Pro Val Ala Ala Arg Gln Gly Gln Glu Thr Ala Val Ala Pro 
1               5                   10                  15      
Ser Leu Val Ala Pro Ala Leu Asn Lys Pro Lys Lys Pro Leu Thr Ser 
            20                  25                  30          
Ser Ser Ala Ala Pro Gln Arg Pro Ile Ser Thr Gln Arg Thr Ala Ala 
        35                  40                  45              
Ala Pro Lys Ala Gly Pro Gly Val Val Arg Lys Asn Pro Gly Val Gly 
    50                  55                  60                  
Asn Gly Asp Asp Glu Ala Ala Glu Leu Met Gln Gln Val Asn Val Leu 
65                  70                  75                  80  
Lys Leu Thr Val Glu Asp Leu Glu Lys Glu Arg Asp Phe Tyr Phe Gly 
                85                  90                  95      
Lys Leu Arg Asn Ile Glu Leu Ile Cys Gln Glu Asn Glu Gly Glu Asn 
            100                 105                 110         
Asp Pro Val Leu Gln Arg Ile Val Asp Ile Leu Tyr Ala Thr Asp Glu 
        115                 120                 125             
Gly Phe Val Ile Pro Asp Glu Gly Gly Pro Gln Glu Glu Gln Glu Glu 
    130                 135                 140                 
Tyr 
145 

<210> 7
<211> 451
<212> PRT
<213> Homo sapiens


<400> 7
Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      
Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          
Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              
Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  
Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  
Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      
Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         
Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             
Cys Thr Arg Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 
Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 
Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     
Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         
Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             
Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 
Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 
Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     
Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         
Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             
Ala Asp Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 
Cys Asp Pro Gly His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 
Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     
Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         
Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             
Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 
Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 
Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     
Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         
Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             
Glu Glu Tyr 
    450     

<210> 8
<211> 444
<212> PRT
<213> Homo sapiens


<400> 8
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      
Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          
Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser 
        35                  40                  45              
Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  
Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  
Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      
Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         
Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             
Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 
Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 
Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     
Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         
Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             
Asp Ile Cys Phe Arg Thr Leu Arg Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 
Leu Asn His Leu Val Ser Gly Thr Met Glu Cys Val Thr Thr Cys Leu 
225                 230                 235                 240 
Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     
Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         
Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Asp 
        275                 280                 285             
Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 
Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 
Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     
Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         
Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile 
        355                 360                 365             
Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 
Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 
Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     
Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         
Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
        435                 440                 

<210> 9
<211> 150
<212> PRT
<213> Homo sapiens


<400> 9
Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      
Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          
Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              
Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  
Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  
Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      
Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         
Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             
Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 
Ala Asp Gly Lys Thr Lys 
145                 150 

<210> 10
<211> 441
<212> PRT
<213> Homo sapiens


<400> 10
Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      
Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          
Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              
Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  
Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  
Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      
Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         
Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             
Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 
Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 
Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     
Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         
Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             
Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 
Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 
Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     
Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         
Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             
Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 
Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 
Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     
Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         
Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             
Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 
Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 
Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     
Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         
Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     

<210> 11
<211> 32
<212> PRT
<213> Homo sapiens


<400> 11
Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      
Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          



<210> 12
<211> 31
<212> PRT
<213> Homo sapiens


<400> 12
Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      
Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30      

<210> 13
<211> 31
<212> PRT
<213> Homo sapiens


<400> 13
Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      
Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
            20                  25                  30      

<210> 14
<211> 32
<212> PRT
<213> Homo sapiens


<400> 14
Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
1               5                   10                  15      
Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
            20                  25                  30          



