                         SEQUENCE LISTING

<110>  UNIVERSITE CLAUDE BERNARD LYON I
       HOSPICES CIVILS DE LYON

<120>  Protine modifie avec demi-vie amliore

<130>  B374416PCT D37754

<150>  FR1757257
<151>  2017-07-28

<160>  36

<170>  PatentIn version 3.5

<210>  1
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn Gly Arg Ile Ala 
1               5                   10                  15      


Gln Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro Met Ser Ile Asp 
            20                  25                  30          


Lys Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr Thr Glu Ser Gly 
        35                  40                  45              


Arg Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly Trp Ser Pro Glu 
    50                  55                  60                  


Pro Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu Ser Asn Gly Tyr 
65                  70                  75                  80  


Ile Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu Asn Met Arg Tyr 
                85                  90                  95      


Gly Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys Asp Glu Glu Val 
            100                 105                 110         


Val Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro Thr Cys Arg Lys 
        115                 120                 125             


Glu His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn Gly Asn Tyr Ser 
    130                 135                 140                 


Thr Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val Gln Tyr Glu Cys 
145                 150                 155                 160 


Ala Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr Glu Glu Val Glu 
                165                 170                 175     


Cys Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys Thr Lys Leu Lys 
            180                 185                 190         


Cys Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe His Pro Val Lys 
        195                 200                 205             


Gln Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe Cys His Glu Asn 
    210                 215                 220                 


Tyr Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr Asn Phe Gly Trp 
225                 230                 235                 240 


Tyr Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn Arg Cys Pro Pro 
                245                 250                 255     


Pro Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His Ser Thr Thr Tyr 
            260                 265                 270         


Arg His Gly Glu Ile Val His Ile Glu Cys Glu Leu Asn Phe Glu Ile 
        275                 280                 285             


His Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys Trp Thr Glu Pro 
    290                 295                 300                 


Pro Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys Glu Glu Pro Pro 
305                 310                 315                 320 


Phe Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys Ile Tyr Tyr Asn 
                325                 330                 335     


Gly Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr Leu Leu His Gly 
            340                 345                 350         


Ser Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr Leu Pro Pro Glu 
        355                 360                 365             


Cys Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro Val Val Met Asn 
    370                 375                 380                 


Gly Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala Thr Gly Ser Ser 
385                 390                 395                 400 


Val Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg Gly Ser Lys Ile 
                405                 410                 415     


Ser Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro Val Cys Leu Glu 
            420                 425                 430         


Pro Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn Asn Ile Glu Met 
        435                 440                 445             


Lys Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp Leu Ile Asp Phe 
    450                 455                 460                 


Val Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr Pro Leu Ser Glu 
465                 470                 475                 480 


Leu Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr Pro Leu Cys Thr 
                485                 490                 495     


Arg Lys Glu Ser Lys Gly Met Cys Thr Ser Pro Pro Leu Ile Lys His 
            500                 505                 510         


Gly Val Ile Ile Ser Ser Thr Val Asp Thr Tyr Glu Asn Gly Ser Ser 
        515                 520                 525             


Val Glu Tyr Arg Cys Phe Asp His His Phe Leu Glu Gly Ser Arg Glu 
    530                 535                 540                 


Ala Tyr Cys Leu Asp Gly Met Trp Thr Thr Pro Pro Leu Cys Leu Glu 
545                 550                 555                 560 


Pro Cys Thr Leu Ser Phe Thr Glu Met Glu Lys Asn Asn Leu Leu Leu 
                565                 570                 575     


Lys Trp Asp Phe Asp Asn Arg Pro His Ile Leu His Gly Glu Tyr Ile 
            580                 585                 590         


Glu Phe Ile Cys Arg Gly Asp Thr Tyr Pro Ala Glu Leu Tyr Ile Thr 
        595                 600                 605             


Gly Ser Ile Leu Arg Met Gln Cys Asp Arg Gly Gln Leu Lys Tyr Pro 
    610                 615                 620                 


Arg Cys Ile Pro Arg Gln Ser Thr Leu Ser Tyr Gln Glu Pro Leu Arg 
625                 630                 635                 640 


Thr 
    


<210>  2
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  3
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro 
                405     


<210>  4
<211>  2332
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  5
<211>  1759
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ala Leu Lys Gln Phe Arg Leu Pro Leu Glu Glu Thr 
            740                 745                 750         


Glu Leu Glu Lys Arg Ile Ile Val Asp Asp Thr Ser Thr Gln Trp Ser 
        755                 760                 765             


Lys Asn Met Lys His Leu Thr Pro Ser Thr Leu Thr Gln Ile Asp Tyr 
    770                 775                 780                 


Asn Glu Lys Glu Lys Gly Ala Ile Thr Gln Ser Pro Leu Ser Asp Cys 
785                 790                 795                 800 


Leu Thr Arg Ser His Ser Ile Pro Gln Ala Asn Arg Ser Pro Leu Pro 
                805                 810                 815     


Ile Ala Lys Val Ser Ser Phe Pro Ser Ile Arg Pro Ile Tyr Leu Thr 
            820                 825                 830         


Arg Val Leu Phe Gln Asp Asn Ser Ser His Leu Pro Ala Ala Ser Tyr 
        835                 840                 845             


Arg Lys Lys Asp Ser Gly Val Gln Glu Ser Ser His Phe Leu Gln Gly 
    850                 855                 860                 


Ala Lys Lys Asn Asn Leu Ser Leu Ala Ile Leu Thr Leu Glu Met Thr 
865                 870                 875                 880 


Gly Asp Gln Arg Glu Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser 
                885                 890                 895     


Val Thr Tyr Lys Lys Val Glu Asn Thr Val Leu Pro Lys Pro Asp Leu 
            900                 905                 910         


Pro Lys Thr Ser Gly Lys Val Glu Leu Leu Pro Lys Val His Ile Tyr 
        915                 920                 925             


Gln Lys Asp Leu Phe Pro Thr Glu Thr Ser Asn Gly Ser Pro Gly His 
    930                 935                 940                 


Leu Asp Leu Val Glu Gly Ser Leu Leu Gln Gly Thr Glu Gly Ala Ile 
945                 950                 955                 960 


Lys Trp Asn Glu Ala Asn Arg Pro Gly Lys Val Pro Phe Leu Arg Val 
                965                 970                 975     


Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser Lys Leu Leu Asp Pro Leu 
            980                 985                 990         


Ala Trp Asp Asn His Tyr Gly Thr  Gln Ile Pro Lys Glu  Glu Trp Lys 
        995                 1000                 1005             


Ser Gln  Glu Lys Ser Pro Glu  Lys Thr Ala Phe Lys  Lys Lys Asp 
    1010                 1015                 1020             


Thr Ile  Leu Ser Leu Asn Ala  Cys Glu Ser Asn His  Ala Ile Ala 
    1025                 1030                 1035             


Ala Ile  Asn Glu Gly Gln Asn  Lys Pro Glu Ile Glu  Val Thr Trp 
    1040                 1045                 1050             


Ala Lys  Gln Gly Arg Thr Glu  Arg Leu Cys Ser Gln  Asn Pro Pro 
    1055                 1060                 1065             


Val Leu  Lys Arg His Gln Arg  Glu Ile Thr Arg Thr  Thr Leu Gln 
    1070                 1075                 1080             


Ser Asp  Gln Glu Glu Ile Asp  Tyr Asp Asp Thr Ile  Ser Val Glu 
    1085                 1090                 1095             


Met Lys  Lys Glu Asp Phe Asp  Ile Tyr Asp Glu Asp  Glu Asn Gln 
    1100                 1105                 1110             


Ser Pro  Arg Ser Phe Gln Lys  Lys Thr Arg His Tyr  Phe Ile Ala 
    1115                 1120                 1125             


Ala Val  Glu Arg Leu Trp Asp  Tyr Gly Met Ser Ser  Ser Pro His 
    1130                 1135                 1140             


Val Leu  Arg Asn Arg Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys 
    1145                 1150                 1155             


Lys Val  Val Phe Gln Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro 
    1160                 1165                 1170             


Leu Tyr  Arg Gly Glu Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro 
    1175                 1180                 1185             


Tyr Ile  Arg Ala Glu Val Glu  Asp Asn Ile Met Val  Thr Phe Arg 
    1190                 1195                 1200             


Asn Gln  Ala Ser Arg Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser 
    1205                 1210                 1215             


Tyr Glu  Glu Asp Gln Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe 
    1220                 1225                 1230             


Val Lys  Pro Asn Glu Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His 
    1235                 1240                 1245             


His Met  Ala Pro Thr Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Val Asp Leu  Glu Lys Asp Val His  Ser Gly Leu 
    1265                 1270                 1275             


Ile Gly  Pro Leu Leu Val Cys  His Thr Asn Thr Leu  Asn Pro Ala 
    1280                 1285                 1290             


His Gly  Arg Gln Val Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr 
    1295                 1300                 1305             


Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu 
    1310                 1315                 1320             


Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr 
    1325                 1330                 1335             


Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile Asn Gly  Tyr Ile Met 
    1340                 1345                 1350             


Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg 
    1355                 1360                 1365             


Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu Asn Ile  His Ser Ile 
    1370                 1375                 1380             


His Phe  Ser Gly His Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr 
    1385                 1390                 1395             


Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val 
    1400                 1405                 1410             


Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu 
    1415                 1420                 1425             


Ile Gly  Glu His Leu His Ala  Gly Met Ser Thr Leu  Phe Leu Val 
    1430                 1435                 1440             


Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly Met Ala  Ser Gly His 
    1445                 1450                 1455             


Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp 
    1460                 1465                 1470             


Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala 
    1475                 1480                 1485             


Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu 
    1490                 1495                 1500             


Ala Pro  Met Ile Ile His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln 
    1505                 1510                 1515             


Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser 
    1520                 1525                 1530             


Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly 
    1535                 1540                 1545             


Thr Leu  Met Val Phe Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys 
    1550                 1555                 1560             


His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu 
    1565                 1570                 1575             


His Pro  Thr His Tyr Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu 
    1580                 1585                 1590             


Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu 
    1595                 1600                 1605             


Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe 
    1610                 1615                 1620             


Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser Lys Ala  Arg Leu His 
    1625                 1630                 1635             


Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro 
    1640                 1645                 1650             


Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys Thr Met  Lys Val Thr 
    1655                 1660                 1665             


Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr 
    1670                 1675                 1680             


Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln Asp Gly  His Gln Trp 
    1685                 1690                 1695             


Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn 
    1700                 1705                 1710             


Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu 
    1715                 1720                 1725             


Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln Ser Trp  Val His Gln 
    1730                 1735                 1740             


Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys Glu Ala  Gln Asp Leu 
    1745                 1750                 1755             


Tyr 
    


<210>  6
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg Ser Val 
    130                 135                 140                 


Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile Thr Trp 
145                 150                 155                 160 


Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro Phe Asp 
                165                 170                 175     


Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn Asn Leu 
            180                 185                 190         


Thr Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp 
        195                 200                 205             


Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr 
    210                 215                 220                 


Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln 
225                 230                 235                 240 


Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu 
                245                 250                 255     


Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn 
            260                 265                 270         


Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu 
        275                 280                 285             


Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro 
    290                 295                 300                 


Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile 
305                 310                 315                 320 


Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg 
                325                 330                 335     


Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu 
            340                 345                 350         


Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp 
        355                 360                 365             


Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val 
    370                 375                 380                 


Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly 
385                 390                 395                 400 


Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr 
                405                 410                 415     


Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro 
            420                 425                 430         


Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
        435                 440                 445             


<210>  7
<211>  2791
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Val Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu 
            740                 745                 750         


Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys 
        755                 760                 765             


Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser 
    770                 775                 780                 


Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val 
785                 790                 795                 800 


Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro 
                805                 810                 815     


Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Gln Asp Arg 
            820                 825                 830         


Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile 
        835                 840                 845             


Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro 
    850                 855                 860                 


Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro 
865                 870                 875                 880 


Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser 
                885                 890                 895     


Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile 
            900                 905                 910         


Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu 
        915                 920                 925             


Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu 
    930                 935                 940                 


Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val 
945                 950                 955                 960 


Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn 
                965                 970                 975     


Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val 
            980                 985                 990         


Glu Glu Asp Pro Val Asp Phe Gly  Asn Ser Trp Lys Val  Ser Ser Gln 
        995                 1000                 1005             


Cys Ala  Asp Thr Arg Lys Val  Pro Leu Asp Ser Ser  Pro Ala Thr 
    1010                 1015                 1020             


Cys His  Asn Asn Ile Met Lys  Gln Thr Met Val Asp  Ser Ser Cys 
    1025                 1030                 1035             


Arg Ile  Leu Thr Ser Asp Val  Phe Gln Asp Cys Asn  Lys Leu Val 
    1040                 1045                 1050             


Asp Pro  Glu Pro Tyr Leu Asp  Val Cys Ile Tyr Asp  Thr Cys Ser 
    1055                 1060                 1065             


Cys Glu  Ser Ile Gly Asp Cys  Ala Cys Phe Cys Asp  Thr Ile Ala 
    1070                 1075                 1080             


Ala Tyr  Ala His Val Cys Ala  Gln His Gly Lys Val  Val Thr Trp 
    1085                 1090                 1095             


Arg Thr  Ala Thr Leu Cys Pro  Gln Ser Cys Glu Glu  Arg Asn Leu 
    1100                 1105                 1110             


Arg Glu  Asn Gly Tyr Glu Cys  Glu Trp Arg Tyr Asn  Ser Cys Ala 
    1115                 1120                 1125             


Pro Ala  Cys Gln Val Thr Cys  Gln His Pro Glu Pro  Leu Ala Cys 
    1130                 1135                 1140             


Pro Val  Gln Cys Val Glu Gly  Cys His Ala His Cys  Pro Pro Gly 
    1145                 1150                 1155             


Lys Ile  Leu Asp Glu Leu Leu  Gln Thr Cys Val Asp  Pro Glu Asp 
    1160                 1165                 1170             


Cys Pro  Val Cys Glu Val Ala  Gly Arg Arg Phe Ala  Ser Gly Lys 
    1175                 1180                 1185             


Lys Val  Thr Leu Asn Pro Ser  Asp Pro Glu His Cys  Gln Ile Cys 
    1190                 1195                 1200             


His Cys  Asp Val Val Asn Leu  Thr Cys Glu Ala Cys  Gln Glu Pro 
    1205                 1210                 1215             


Gly Gly  Leu Val Val Pro Pro  Thr Asp Ala Pro Val  Ser Pro Thr 
    1220                 1225                 1230             


Thr Leu  Tyr Val Glu Asp Ile  Ser Glu Pro Pro Leu  His Asp Phe 
    1235                 1240                 1245             


Tyr Cys  Ser Arg Leu Leu Asp  Leu Val Phe Leu Leu  Asp Gly Ser 
    1250                 1255                 1260             


Ser Arg  Leu Ser Glu Ala Glu  Phe Glu Val Leu Lys  Ala Phe Val 
    1265                 1270                 1275             


Val Asp  Met Met Glu Arg Leu  Arg Ile Ser Gln Lys  Trp Val Arg 
    1280                 1285                 1290             


Val Ala  Val Val Glu Tyr His  Asp Gly Ser His Ala  Tyr Ile Gly 
    1295                 1300                 1305             


Leu Lys  Asp Arg Lys Arg Pro  Ser Glu Leu Arg Arg  Ile Ala Ser 
    1310                 1315                 1320             


Gln Val  Lys Tyr Ala Gly Ser  Gln Val Ala Ser Thr  Ser Glu Val 
    1325                 1330                 1335             


Leu Lys  Tyr Thr Leu Phe Gln  Ile Phe Ser Lys Ile  Asp Arg Pro 
    1340                 1345                 1350             


Glu Ala  Ser Arg Ile Thr Leu  Leu Leu Met Ala Ser  Gln Glu Pro 
    1355                 1360                 1365             


Gln Arg  Met Ser Arg Asn Phe  Val Arg Tyr Val Gln  Gly Leu Lys 
    1370                 1375                 1380             


Lys Lys  Lys Val Ile Val Ile  Pro Val Gly Ile Gly  Pro His Ala 
    1385                 1390                 1395             


Asn Leu  Lys Gln Ile Arg Leu  Ile Glu Lys Gln Ala  Pro Glu Asn 
    1400                 1405                 1410             


Lys Ala  Phe Val Leu Ser Ser  Val Asp Glu Leu Glu  Gln Gln Arg 
    1415                 1420                 1425             


Asp Glu  Ile Val Ser Tyr Leu  Cys Asp Leu Ala Pro  Glu Ala Pro 
    1430                 1435                 1440             


Pro Pro  Thr Leu Pro Pro Asp  Met Ala Gln Val Thr  Val Gly Pro 
    1445                 1450                 1455             


Gly Leu  Leu Gly Val Ser Thr  Leu Gly Pro Lys Arg  Asn Ser Met 
    1460                 1465                 1470             


Val Leu  Asp Val Ala Phe Val  Leu Glu Gly Ser Asp  Lys Ile Gly 
    1475                 1480                 1485             


Glu Ala  Asp Phe Asn Arg Ser  Lys Glu Phe Met Glu  Glu Val Ile 
    1490                 1495                 1500             


Gln Arg  Met Asp Val Gly Gln  Asp Ser Ile His Val  Thr Val Leu 
    1505                 1510                 1515             


Gln Tyr  Ser Tyr Met Val Thr  Val Glu Tyr Pro Phe  Ser Glu Ala 
    1520                 1525                 1530             


Gln Ser  Lys Gly Asp Ile Leu  Gln Arg Val Arg Glu  Ile Arg Tyr 
    1535                 1540                 1545             


Gln Gly  Gly Asn Arg Thr Asn  Thr Gly Leu Ala Leu  Arg Tyr Leu 
    1550                 1555                 1560             


Ser Asp  His Ser Phe Leu Val  Ser Gln Gly Asp Arg  Glu Gln Ala 
    1565                 1570                 1575             


Pro Asn  Leu Val Tyr Met Val  Thr Gly Asn Pro Ala  Ser Asp Glu 
    1580                 1585                 1590             


Ile Lys  Arg Leu Pro Gly Asp  Ile Gln Val Val Pro  Ile Gly Val 
    1595                 1600                 1605             


Gly Pro  Asn Ala Asn Val Gln  Glu Leu Glu Arg Ile  Gly Trp Pro 
    1610                 1615                 1620             


Asn Ala  Pro Ile Leu Ile Gln  Asp Phe Glu Thr Leu  Pro Arg Glu 
    1625                 1630                 1635             


Ala Pro  Asp Leu Val Leu Gln  Arg Cys Cys Ser Gly  Glu Gly Leu 
    1640                 1645                 1650             


Gln Ile  Pro Thr Leu Ser Pro  Ala Pro Asp Cys Ser  Gln Pro Leu 
    1655                 1660                 1665             


Asp Val  Ile Leu Leu Leu Asp  Gly Ser Ser Ser Phe  Pro Ala Ser 
    1670                 1675                 1680             


Tyr Phe  Asp Glu Met Lys Ser  Phe Ala Lys Ala Phe  Ile Ser Lys 
    1685                 1690                 1695             


Ala Asn  Ile Gly Pro Arg Leu  Thr Gln Val Ser Val  Leu Gln Tyr 
    1700                 1705                 1710             


Gly Ser  Ile Thr Thr Ile Asp  Val Pro Trp Asn Val  Val Pro Glu 
    1715                 1720                 1725             


Lys Ala  His Leu Leu Ser Leu  Val Asp Val Met Gln  Arg Glu Gly 
    1730                 1735                 1740             


Gly Pro  Ser Gln Ile Gly Asp  Ala Leu Gly Phe Ala  Val Arg Tyr 
    1745                 1750                 1755             


Leu Thr  Ser Glu Met His Gly  Ala Arg Pro Gly Ala  Ser Lys Ala 
    1760                 1765                 1770             


Val Val  Ile Leu Val Thr Asp  Val Ser Val Asp Ser  Val Asp Ala 
    1775                 1780                 1785             


Ala Ala  Asp Ala Ala Arg Ser  Asn Arg Val Thr Val  Phe Pro Ile 
    1790                 1795                 1800             


Gly Ile  Gly Asp Arg Tyr Asp  Ala Ala Gln Leu Arg  Ile Leu Ala 
    1805                 1810                 1815             


Gly Pro  Ala Gly Asp Ser Asn  Val Val Lys Leu Gln  Arg Ile Glu 
    1820                 1825                 1830             


Asp Leu  Pro Thr Met Val Thr  Leu Gly Asn Ser Phe  Leu His Lys 
    1835                 1840                 1845             


Leu Cys  Ser Gly Phe Val Arg  Ile Cys Met Asp Glu  Asp Gly Asn 
    1850                 1855                 1860             


Glu Lys  Arg Pro Gly Asp Val  Trp Thr Leu Pro Asp  Gln Cys His 
    1865                 1870                 1875             


Thr Val  Thr Cys Gln Pro Asp  Gly Gln Thr Leu Leu  Lys Ser His 
    1880                 1885                 1890             


Arg Val  Asn Cys Asp Arg Gly  Leu Arg Pro Ser Cys  Pro Asn Ser 
    1895                 1900                 1905             


Gln Ser  Pro Val Lys Val Glu  Glu Thr Cys Gly Cys  Arg Trp Thr 
    1910                 1915                 1920             


Cys Pro  Cys Val Cys Thr Gly  Ser Ser Thr Arg His  Ile Val Thr 
    1925                 1930                 1935             


Phe Asp  Gly Gln Asn Phe Lys  Leu Thr Gly Ser Cys  Ser Tyr Val 
    1940                 1945                 1950             


Leu Phe  Gln Asn Lys Glu Gln  Asp Leu Glu Val Ile  Leu His Asn 
    1955                 1960                 1965             


Gly Ala  Cys Ser Pro Gly Ala  Arg Gln Gly Cys Met  Lys Ser Ile 
    1970                 1975                 1980             


Glu Val  Lys His Ser Ala Leu  Ser Val Glu Leu His  Ser Asp Met 
    1985                 1990                 1995             


Glu Val  Thr Val Asn Gly Arg  Leu Val Ser Val Pro  Tyr Val Gly 
    2000                 2005                 2010             


Gly Asn  Met Glu Val Asn Val  Tyr Gly Ala Ile Met  His Glu Val 
    2015                 2020                 2025             


Arg Phe  Asn His Leu Gly His  Ile Phe Thr Phe Thr  Pro Gln Asn 
    2030                 2035                 2040             


Asn Glu  Phe Gln Leu Gln Leu  Ser Pro Lys Thr Phe  Ala Ser Lys 
    2045                 2050                 2055             


Thr Tyr  Gly Leu Cys Gly Ile  Cys Asp Glu Asn Gly  Ala Asn Asp 
    2060                 2065                 2070             


Phe Met  Leu Arg Asp Gly Thr  Val Thr Thr Asp Trp  Lys Thr Leu 
    2075                 2080                 2085             


Val Gln  Glu Trp Thr Val Gln  Arg Pro Gly Gln Thr  Cys Gln Pro 
    2090                 2095                 2100             


Ile Leu  Glu Glu Gln Cys Leu  Val Pro Asp Ser Ser  His Cys Gln 
    2105                 2110                 2115             


Val Leu  Leu Leu Pro Leu Phe  Ala Glu Cys His Lys  Val Leu Ala 
    2120                 2125                 2130             


Pro Ala  Thr Phe Tyr Ala Ile  Cys Gln Gln Asp Ser  Cys His Gln 
    2135                 2140                 2145             


Glu Gln  Val Cys Glu Val Ile  Ala Ser Tyr Ala His  Leu Cys Arg 
    2150                 2155                 2160             


Thr Asn  Gly Val Cys Val Asp  Trp Arg Thr Pro Asp  Phe Cys Ala 
    2165                 2170                 2175             


Met Ser  Cys Pro Pro Ser Leu  Val Tyr Asn His Cys  Glu His Gly 
    2180                 2185                 2190             


Cys Pro  Arg His Cys Asp Gly  Asn Val Ser Ser Cys  Gly Asp His 
    2195                 2200                 2205             


Pro Ser  Glu Gly Cys Phe Cys  Pro Pro Asp Lys Val  Met Leu Glu 
    2210                 2215                 2220             


Gly Ser  Cys Val Pro Glu Glu  Ala Cys Thr Gln Cys  Ile Gly Glu 
    2225                 2230                 2235             


Asp Gly  Val Gln His Gln Phe  Leu Glu Ala Trp Val  Pro Asp His 
    2240                 2245                 2250             


Gln Pro  Cys Gln Ile Cys Thr  Cys Leu Ser Gly Arg  Lys Val Asn 
    2255                 2260                 2265             


Cys Thr  Thr Gln Pro Cys Pro  Thr Ala Lys Ala Pro  Thr Cys Gly 
    2270                 2275                 2280             


Leu Cys  Glu Val Ala Arg Leu  Arg Gln Asn Ala Asp  Gln Cys Cys 
    2285                 2290                 2295             


Pro Glu  Tyr Glu Cys Val Cys  Asp Pro Val Ser Cys  Asp Leu Pro 
    2300                 2305                 2310             


Pro Val  Pro His Cys Glu Arg  Gly Leu Gln Pro Thr  Leu Thr Asn 
    2315                 2320                 2325             


Pro Gly  Glu Cys Arg Pro Asn  Phe Thr Cys Ala Cys  Arg Lys Glu 
    2330                 2335                 2340             


Glu Cys  Lys Arg Val Ser Pro  Pro Ser Cys Pro Pro  His Arg Leu 
    2345                 2350                 2355             


Pro Thr  Leu Arg Lys Thr Gln  Cys Cys Asp Glu Tyr  Glu Cys Ala 
    2360                 2365                 2370             


Cys Asn  Cys Val Asn Ser Thr  Val Ser Cys Pro Leu  Gly Tyr Leu 
    2375                 2380                 2385             


Ala Ser  Thr Ala Thr Asn Asp  Cys Gly Cys Thr Thr  Thr Thr Cys 
    2390                 2395                 2400             


Leu Pro  Asp Lys Val Cys Val  His Arg Ser Thr Ile  Tyr Pro Val 
    2405                 2410                 2415             


Gly Gln  Phe Trp Glu Glu Gly  Cys Asp Val Cys Thr  Cys Thr Asp 
    2420                 2425                 2430             


Met Glu  Asp Ala Val Met Gly  Leu Arg Val Ala Gln  Cys Ser Gln 
    2435                 2440                 2445             


Lys Pro  Cys Glu Asp Ser Cys  Arg Ser Gly Phe Thr  Tyr Val Leu 
    2450                 2455                 2460             


His Glu  Gly Glu Cys Cys Gly  Arg Cys Leu Pro Ser  Ala Cys Glu 
    2465                 2470                 2475             


Val Val  Thr Gly Ser Pro Arg  Gly Asp Ser Gln Ser  Ser Trp Lys 
    2480                 2485                 2490             


Ser Val  Gly Ser Gln Trp Ala  Ser Pro Glu Asn Pro  Cys Leu Ile 
    2495                 2500                 2505             


Asn Glu  Cys Val Arg Val Lys  Glu Glu Val Phe Ile  Gln Gln Arg 
    2510                 2515                 2520             


Asn Val  Ser Cys Pro Gln Leu  Glu Val Pro Val Cys  Pro Ser Gly 
    2525                 2530                 2535             


Phe Gln  Leu Ser Cys Lys Thr  Ser Ala Cys Cys Pro  Ser Cys Arg 
    2540                 2545                 2550             


Cys Glu  Arg Met Glu Ala Cys  Met Leu Asn Gly Thr  Val Ile Gly 
    2555                 2560                 2565             


Pro Gly  Lys Thr Val Met Ile  Asp Val Cys Thr Thr  Cys Arg Cys 
    2570                 2575                 2580             


Met Val  Gln Val Gly Val Ile  Ser Gly Phe Lys Leu  Glu Cys Arg 
    2585                 2590                 2595             


Lys Thr  Thr Cys Asn Pro Cys  Pro Leu Gly Tyr Lys  Glu Glu Asn 
    2600                 2605                 2610             


Asn Thr  Gly Glu Cys Cys Gly  Arg Cys Leu Pro Thr  Ala Cys Thr 
    2615                 2620                 2625             


Ile Gln  Leu Arg Gly Gly Gln  Ile Met Thr Leu Lys  Arg Asp Glu 
    2630                 2635                 2640             


Thr Leu  Gln Asp Gly Cys Asp  Thr His Phe Cys Lys  Val Asn Glu 
    2645                 2650                 2655             


Arg Gly  Glu Tyr Phe Trp Glu  Lys Arg Val Thr Gly  Cys Pro Pro 
    2660                 2665                 2670             


Phe Asp  Glu His Lys Cys Leu  Ala Glu Gly Gly Lys  Ile Met Lys 
    2675                 2680                 2685             


Ile Pro  Gly Thr Cys Cys Asp  Thr Cys Glu Glu Pro  Glu Cys Asn 
    2690                 2695                 2700             


Asp Ile  Thr Ala Arg Leu Gln  Tyr Val Lys Val Gly  Ser Cys Lys 
    2705                 2710                 2715             


Ser Glu  Val Glu Val Asp Ile  His Tyr Cys Gln Gly  Lys Cys Ala 
    2720                 2725                 2730             


Ser Lys  Ala Met Tyr Ser Ile  Asp Ile Asn Asp Val  Gln Asp Gln 
    2735                 2740                 2745             


Cys Ser  Cys Cys Ser Pro Thr  Arg Thr Glu Pro Met  Gln Val Ala 
    2750                 2755                 2760             


Leu His  Cys Thr Asn Gly Ser  Val Val Tyr His Glu  Val Leu Asn 
    2765                 2770                 2775             


Ala Met  Glu Cys Lys Cys Ser  Pro Arg Lys Cys Ser  Lys 
    2780                 2785                 2790     


<210>  8
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  8

His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro 
1               5                   10                  15      


Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu 
            20                  25                  30          


Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val 
        35                  40                  45              


Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln 
    50                  55                  60                  


His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro 
65                  70                  75                  80  


Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn 
                85                  90                  95      


Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser 
            100                 105                 110         


Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys 
        115                 120                 125             


Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn 
    130                 135                 140                 


Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp 
145                 150                 155                 160 


Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys 
                165                 170                 175     


Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn 
            180                 185                 190         


Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn 
        195                 200                 205             


Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu 
    210                 215                 220                 


Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr 
225                 230                 235                 240 


Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly 
                245                 250                 255     


Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu 
            260                 265                 270         


Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro 
        275                 280                 285             


Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu 
    290                 295                 300                 


Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met 
305                 310                 315                 320 


Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln 
                325                 330                 335     


Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro 
            340                 345                 350         


Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe 
        355                 360                 365             


His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala 
    370                 375                 380                 


Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val 
385                 390                 395                 400 


Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro 
                405                 410                 415     


Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys 
            420                 425                 430         


<210>  9
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Asn Ser Phe Leu Glu Glu Leu Arg His Ser Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Ile Glu Glu Ile Cys Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln 
            20                  25                  30          


Asn Val Asp Asp Thr Leu Ala Phe Trp Ser Lys His Val Asp Gly Asp 
        35                  40                  45              


Gln Cys Leu Val Leu Pro Leu Glu His Pro Cys Ala Ser Leu Cys Cys 
    50                  55                  60                  


Gly His Gly Thr Cys Ile Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys 
65                  70                  75                  80  


Arg Ser Gly Trp Glu Gly Arg Phe Cys Gln Arg Glu Val Ser Phe Leu 
                85                  90                  95      


Asn Cys Ser Leu Asp Asn Gly Gly Cys Thr His Tyr Cys Leu Glu Glu 
            100                 105                 110         


Val Gly Trp Arg Arg Cys Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp 
        115                 120                 125             


Asp Leu Leu Gln Cys His Pro Ala Val Lys Phe Pro Cys Gly Arg Pro 
    130                 135                 140                 


Trp Lys Arg Met Glu Lys Lys Arg Ser His Leu Lys Arg Asp Thr Glu 
145                 150                 155                 160 


Asp Gln Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Met Thr 
                165                 170                 175     


Arg Arg Gly Asp Ser Pro Trp Gln Val Val Leu Leu Asp Ser Lys Lys 
            180                 185                 190         


Lys Leu Ala Cys Gly Ala Val Leu Ile His Pro Ser Trp Val Leu Thr 
        195                 200                 205             


Ala Ala His Cys Met Asp Glu Ser Lys Lys Leu Leu Val Arg Leu Gly 
    210                 215                 220                 


Glu Tyr Asp Leu Arg Arg Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile 
225                 230                 235                 240 


Lys Glu Val Phe Val His Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn 
                245                 250                 255     


Asp Ile Ala Leu Leu His Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr 
            260                 265                 270         


Ile Val Pro Ile Cys Leu Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu 
        275                 280                 285             


Asn Gln Ala Gly Gln Glu Thr Leu Val Thr Gly Trp Gly Tyr His Ser 
    290                 295                 300                 


Ser Arg Glu Lys Glu Ala Lys Arg Asn Arg Thr Phe Val Leu Asn Phe 
305                 310                 315                 320 


Ile Lys Ile Pro Val Val Pro His Asn Glu Cys Ser Glu Val Met Ser 
                325                 330                 335     


Asn Met Val Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Arg 
            340                 345                 350         


Gln Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser Phe 
        355                 360                 365             


His Gly Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys 
    370                 375                 380                 


Gly Leu Leu His Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu 
385                 390                 395                 400 


Asp Trp Ile His Gly His Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser 
                405                 410                 415     


Trp Ala Pro 
            


<210>  10
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Asn Phe Leu Ser Lys Gln Gln Ala Ser Gln Val Leu Val Arg Lys 
1               5                   10                  15      


Arg Arg Ala Asn Ser Leu Leu Glu Glu Thr Lys Gln Gly Asn Leu Glu 
            20                  25                  30          


Arg Glu Cys Ile Glu Glu Leu Cys Asn Lys Glu Glu Ala Arg Glu Val 
        35                  40                  45              


Phe Glu Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Lys Tyr Leu Val 
    50                  55                  60                  


Cys Leu Arg Ser Phe Gln Thr Gly Leu Phe Thr Ala Ala Arg Gln Ser 
65                  70                  75                  80  


Thr Asn Ala Tyr Pro Asp Leu Arg Ser Cys Val Asn Ala Ile Pro Asp 
                85                  90                  95      


Gln Cys Ser Pro Leu Pro Cys Asn Glu Asp Gly Tyr Met Ser Cys Lys 
            100                 105                 110         


Asp Gly Lys Ala Ser Phe Thr Cys Thr Cys Lys Pro Gly Trp Gln Gly 
        115                 120                 125             


Glu Lys Cys Glu Phe Asp Ile Asn Glu Cys Lys Asp Pro Ser Asn Ile 
    130                 135                 140                 


Asn Gly Gly Cys Ser Gln Ile Cys Asp Asn Thr Pro Gly Ser Tyr His 
145                 150                 155                 160 


Cys Ser Cys Lys Asn Gly Phe Val Met Leu Ser Asn Lys Lys Asp Cys 
                165                 170                 175     


Lys Asp Val Asp Glu Cys Ser Leu Lys Pro Ser Ile Cys Gly Thr Ala 
            180                 185                 190         


Val Cys Lys Asn Ile Pro Gly Asp Phe Glu Cys Glu Cys Pro Glu Gly 
        195                 200                 205             


Tyr Arg Tyr Asn Leu Lys Ser Lys Ser Cys Glu Asp Ile Asp Glu Cys 
    210                 215                 220                 


Ser Glu Asn Met Cys Ala Gln Leu Cys Val Asn Tyr Pro Gly Gly Tyr 
225                 230                 235                 240 


Thr Cys Tyr Cys Asp Gly Lys Lys Gly Phe Lys Leu Ala Gln Asp Gln 
                245                 250                 255     


Lys Ser Cys Glu Val Val Ser Val Cys Leu Pro Leu Asn Leu Asp Thr 
            260                 265                 270         


Lys Tyr Glu Leu Leu Tyr Leu Ala Glu Gln Phe Ala Gly Val Val Leu 
        275                 280                 285             


Tyr Leu Lys Phe Arg Leu Pro Glu Ile Ser Arg Phe Ser Ala Glu Phe 
    290                 295                 300                 


Asp Phe Arg Thr Tyr Asp Ser Glu Gly Val Ile Leu Tyr Ala Glu Ser 
305                 310                 315                 320 


Ile Asp His Ser Ala Trp Leu Leu Ile Ala Leu Arg Gly Gly Lys Ile 
                325                 330                 335     


Glu Val Gln Leu Lys Asn Glu His Thr Ser Lys Ile Thr Thr Gly Gly 
            340                 345                 350         


Asp Val Ile Asn Asn Gly Leu Trp Asn Met Val Ser Val Glu Glu Leu 
        355                 360                 365             


Glu His Ser Ile Ser Ile Lys Ile Ala Lys Glu Ala Val Met Asp Ile 
    370                 375                 380                 


Asn Lys Pro Gly Pro Leu Phe Lys Pro Glu Asn Gly Leu Leu Glu Thr 
385                 390                 395                 400 


Lys Val Tyr Phe Ala Gly Phe Pro Arg Lys Val Glu Ser Glu Leu Ile 
                405                 410                 415     


Lys Pro Ile Asn Pro Arg Leu Asp Gly Cys Ile Arg Ser Trp Asn Leu 
            420                 425                 430         


Met Lys Gln Gly Ala Ser Gly Ile Lys Glu Ile Ile Gln Glu Lys Gln 
        435                 440                 445             


Asn Lys His Cys Leu Val Thr Val Glu Lys Gly Ser Tyr Tyr Pro Gly 
    450                 455                 460                 


Ser Gly Ile Ala Gln Phe His Ile Asp Tyr Asn Asn Val Ser Ser Ala 
465                 470                 475                 480 


Glu Gly Trp His Val Asn Val Thr Leu Asn Ile Arg Pro Ser Thr Gly 
                485                 490                 495     


Thr Gly Val Met Leu Ala Leu Val Ser Gly Asn Asn Thr Val Pro Phe 
            500                 505                 510         


Ala Val Ser Leu Val Asp Ser Thr Ser Glu Lys Ser Gln Asp Ile Leu 
        515                 520                 525             


Leu Ser Val Glu Asn Thr Val Ile Tyr Arg Ile Gln Ala Leu Ser Leu 
    530                 535                 540                 


Cys Ser Asp Gln Gln Ser His Leu Glu Phe Arg Val Asn Arg Asn Asn 
545                 550                 555                 560 


Leu Glu Leu Ser Thr Pro Leu Lys Ile Glu Thr Ile Ser His Glu Asp 
                565                 570                 575     


Leu Gln Arg Gln Leu Ala Val Leu Asp Lys Ala Met Lys Ala Lys Val 
            580                 585                 590         


Ala Thr Tyr Leu Gly Gly Leu Pro Asp Val Pro Phe Ser Ala Thr Pro 
        595                 600                 605             


Val Asn Ala Phe Tyr Asn Gly Cys Met Glu Val Asn Ile Asn Gly Val 
    610                 615                 620                 


Gln Leu Asp Leu Asp Glu Ala Ile Ser Lys His Asn Asp Ile Arg Ala 
625                 630                 635                 640 


His Ser Cys Pro Ser Val Trp Lys Lys Thr Lys Asn Ser 
                645                 650             


<210>  11
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Leu Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln 
1               5                   10                  15      


Arg Arg Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu 
            20                  25                  30          


Arg Glu Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val 
        35                  40                  45              


Phe Glu Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp 
    50                  55                  60                  


Cys Ile Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala 
65                  70                  75                  80  


Thr Cys Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp 
                85                  90                  95      


Arg Lys Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys 
            100                 105                 110         


Leu Cys Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn 
        115                 120                 125             


Glu Cys Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys 
    130                 135                 140                 


Pro Gly Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser 
145                 150                 155                 160 


Asp Gly Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala 
                165                 170                 175     


Cys Gly Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu 
            180                 185                 190         


Cys Asp Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp 
        195                 200                 205             


Val Asp Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser 
    210                 215                 220                 


Pro Gly Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu 
225                 230                 235                 240 


Ser Gln Asp Met Asp Thr Cys Glu Leu Glu Ala Gly Trp Pro Cys Pro 
                245                 250                 255     


Arg His Arg Arg Asp Gly Ser Pro Ala Ala Arg Pro Gly Arg Gly Ala 
            260                 265                 270         


Gln Gly Ser Arg Ser Glu Gly His Ile Pro Asp Arg Arg Gly Pro Arg 
        275                 280                 285             


Pro Trp Gln Asp Ile Leu Pro Cys Val Pro Phe Ser Val Ala Lys Ser 
    290                 295                 300                 


Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro Val Ile 
305                 310                 315                 320 


Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val Ala Glu Phe 
                325                 330                 335     


Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe Ala Gly Gly 
            340                 345                 350         


His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala Gly Arg Leu 
        355                 360                 365             


Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr Ser Ser Gly 
    370                 375                 380                 


Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val Glu Glu Leu 
385                 390                 395                 400 


Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val Met Lys Ile 
                405                 410                 415     


Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu Tyr His Leu 
            420                 425                 430         


Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp Leu Val Gln 
        435                 440                 445             


Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn Trp Leu 
    450                 455                 460                 


Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val Asn Thr Arg 
465                 470                 475                 480 


Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr Pro Gly Ser 
                485                 490                 495     


Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro Leu Asp Val 
            500                 505                 510         


Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His Ile Arg Pro 
        515                 520                 525             


Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro Asp Leu Arg 
    530                 535                 540                 


Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser Thr Lys Lys 
545                 550                 555                 560 


Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr Ala Leu Ala 
                565                 570                 575     


Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val Val Thr Val 
            580                 585                 590         


Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly Thr Arg Gly 
        595                 600                 605             


Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu Ala Val Leu 
    610                 615                 620                 


Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly Gly Leu Pro 
625                 630                 635                 640 


Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr Arg Gly Cys 
                645                 650                 655     


Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp Glu Ala Ala 
            660                 665                 670         


Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro Val Glu Pro 
        675                 680                 685             


Ala Ala Ala 
    690     


<210>  12
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Gly Ser Tyr Leu Leu Glu Glu Leu Phe Glu Gly Asn Leu Glu Lys 
1               5                   10                  15      


Glu Cys Tyr Glu Glu Ile Cys Val Tyr Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Glu Val Val Thr Asp Glu Phe Trp Arg Arg Tyr Lys Gly Gly 
        35                  40                  45              


Ser Pro Cys Ile Ser Gln Pro Cys Leu His Asn Gly Ser Cys Gln Asp 
    50                  55                  60                  


Ser Ile Trp Gly Tyr Thr Cys Thr Cys Ser Pro Gly Tyr Glu Gly Ser 
65                  70                  75                  80  


Asn Cys Glu Leu Ala Lys Asn Glu Cys His Pro Glu Arg Thr Asp Gly 
                85                  90                  95      


Cys Gln His Phe Cys Leu Pro Gly Gln Glu Ser Tyr Thr Cys Ser Cys 
            100                 105                 110         


Ala Gln Gly Tyr Arg Leu Gly Glu Asp His Lys Gln Cys Val Pro His 
        115                 120                 125             


Asp Gln Cys Ala Cys Gly Val Leu Thr Ser Glu Lys Arg Ala Pro Asp 
    130                 135                 140                 


Leu Gln Asp Leu Pro Trp Gln Val Lys Leu Thr Asn Ser Glu Gly Lys 
145                 150                 155                 160 


Asp Phe Cys Gly Gly Val Ile Ile Arg Glu Asn Phe Val Leu Thr Thr 
                165                 170                 175     


Ala Lys Cys Ser Leu Leu His Arg Asn Ile Thr Val Lys Thr Tyr Phe 
            180                 185                 190         


Asn Arg Thr Ser Gln Asp Pro Leu Met Ile Lys Ile Thr His Val His 
        195                 200                 205             


Val His Met Arg Tyr Asp Ala Asp Ala Gly Glu Asn Asp Leu Ser Leu 
    210                 215                 220                 


Leu Glu Leu Glu Trp Pro Ile Gln Cys Pro Gly Ala Gly Leu Pro Val 
225                 230                 235                 240 


Cys Thr Pro Glu Lys Asp Phe Ala Glu His Leu Leu Ile Pro Arg Thr 
                245                 250                 255     


Arg Gly Leu Leu Ser Gly Trp Ala Arg Asn Gly Thr Asp Leu Gly Asn 
            260                 265                 270         


Ser Leu Thr Thr Arg Pro Val Thr Leu Val Glu Gly Glu Glu Cys Gly 
        275                 280                 285             


Gln Val Leu Asn Val Thr Val Thr Thr Arg Thr Tyr Cys Glu Arg Ser 
    290                 295                 300                 


Ser Val Ala Ala Met His Trp Met Asp Gly Ser Val Val Thr Arg Glu 
305                 310                 315                 320 


His Arg Gly Ser Trp Phe Leu Thr Gly Val Leu Gly Ser Gln Pro Val 
                325                 330                 335     


Gly Gly Gln Ala His Met Val Leu Val Thr Lys Val Ser Arg Tyr Ser 
            340                 345                 350         


Leu Trp Phe Lys Gln Ile Met Asn 
        355                 360 


<210>  13
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Asn Thr Phe Leu Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu 
1               5                   10                  15      


Cys Val Glu Glu Thr Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu 
            20                  25                  30          


Ser Ser Thr Ala Thr Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu 
        35                  40                  45              


Thr Ala Arg Thr Pro Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn 
    50                  55                  60                  


Cys Ala Glu Gly Leu Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr 
65                  70                  75                  80  


Arg Ser Gly Ile Glu Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys 
                85                  90                  95      


Pro Glu Ile Asn Ser Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn 
            100                 105                 110         


Phe Cys Arg Asn Pro Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr 
        115                 120                 125             


Thr Asp Pro Thr Val Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly 
    130                 135                 140                 


Gln Asp Gln Val Thr Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser 
145                 150                 155                 160 


Val Asn Leu Ser Pro Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln 
                165                 170                 175     


Gln Tyr Gln Gly Arg Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu 
            180                 185                 190         


Ala Trp Ala Ser Ala Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe 
        195                 200                 205             


Asn Ser Ala Val Gln Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly 
    210                 215                 220                 


Asp Glu Glu Gly Val Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe 
225                 230                 235                 240 


Gly Tyr Cys Asp Leu Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr 
                245                 250                 255     


Gly Asp Gly Leu Asp Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr 
            260                 265                 270         


Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser 
        275                 280                 285             


Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu 
    290                 295                 300                 


Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg 
305                 310                 315                 320 


Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val 
                325                 330                 335     


Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu 
            340                 345                 350         


Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro 
        355                 360                 365             


Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly 
    370                 375                 380                 


Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met 
385                 390                 395                 400 


Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu 
                405                 410                 415     


Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser 
            420                 425                 430         


Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser 
        435                 440                 445             


Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu 
    450                 455                 460                 


Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu 
465                 470                 475                 480 


Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser 
                485                 490                 495     


Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro 
            500                 505                 510         


Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile 
    530                 535                 540                 


Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr 
545                 550                 555                 560 


Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln 
                565                 570                 575     


Phe Gly Glu 
            


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence d'acides amins clivable par le FXa

<400>  14

Arg Leu Val Gly Gly Gln Glu 
1               5           


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence d'acides amins bis clivable par le FXa

<400>  15

Thr Arg Ile Glu Gly Arg Ile Val 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence d'acides amins clivable par le FXIa et le FVIIa-TF

<400>  16

Lys Leu Thr Arg Ala Glu Thr Val 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence d'acides amins bis clivable par le FXIa et le FVIIa-TF

<400>  17

Asp Phe Thr Arg Val Val Gly Gly 
1               5               


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence d'acides amins clivable par le FIIa

<400>  18

Gly Pro Arg Ser Phe Leu 
1               5       


<210>  19
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptidique clivable par le FXa (LXa)

<400>  19

Thr Arg Ile Glu Gly Arg Ile Val Ser Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Ala Ala 
            20                  25                  30          


Ala Met 
        


<210>  20
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptidique clivable par le FIIa (LIIa)

<400>  20

Gly Pro Arg Ser Phe Leu Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Ala Ala Ala Met 
            20                  25                  30          


<210>  21
<211>  1136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protine de fusion FIX-LXa-FXIIIB avec linker peptidique clivable
       comprenant TRIEGRIV, avec propeptide et avec peptide signal

<400>  21

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Thr Arg Ile 
    450                 455                 460                 


Glu Gly Arg Ile Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Ala Ala Ala Met Glu 
                485                 490                 495     


Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn Gly Arg Ile Ala Gln 
            500                 505                 510         


Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro Met Ser Ile Asp Lys 
        515                 520                 525             


Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr Thr Glu Ser Gly Arg 
    530                 535                 540                 


Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly Trp Ser Pro Glu Pro 
545                 550                 555                 560 


Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu Ser Asn Gly Tyr Ile 
                565                 570                 575     


Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu Asn Met His Tyr Gly 
            580                 585                 590         


Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys Asp Glu Glu Val Val 
        595                 600                 605             


Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro Thr Cys Arg Lys Glu 
    610                 615                 620                 


His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn Gly Asn Tyr Ser Thr 
625                 630                 635                 640 


Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val Gln Tyr Glu Cys Ala 
                645                 650                 655     


Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr Glu Glu Val Glu Cys 
            660                 665                 670         


Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys Thr Lys Leu Lys Cys 
        675                 680                 685             


Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe His Pro Val Lys Gln 
    690                 695                 700                 


Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe Cys His Glu Asn Tyr 
705                 710                 715                 720 


Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr Asn Phe Gly Trp Tyr 
                725                 730                 735     


Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn Arg Cys Pro Pro Pro 
            740                 745                 750         


Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His Ser Thr Thr Tyr Arg 
        755                 760                 765             


His Gly Glu Ile Val His Ile Glu Cys Glu Leu Asn Phe Glu Ile His 
    770                 775                 780                 


Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys Trp Thr Glu Pro Pro 
785                 790                 795                 800 


Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys Glu Glu Pro Pro Phe 
                805                 810                 815     


Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys Ile Tyr Tyr Asn Gly 
            820                 825                 830         


Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr Leu Leu His Gly Ser 
        835                 840                 845             


Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr Leu Pro Pro Glu Cys 
    850                 855                 860                 


Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro Val Val Met Asn Gly 
865                 870                 875                 880 


Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala Thr Gly Ser Ser Val 
                885                 890                 895     


Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg Gly Ser Lys Ile Ser 
            900                 905                 910         


Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro Val Cys Leu Glu Pro 
        915                 920                 925             


Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn Asn Ile Glu Met Lys 
    930                 935                 940                 


Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp Leu Ile Asp Phe Val 
945                 950                 955                 960 


Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr Pro Leu Ser Glu Leu 
                965                 970                 975     


Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr Pro Leu Cys Thr Arg 
            980                 985                 990         


Lys Glu Ser Lys Gly Met Cys Thr  Ser Pro Pro Leu Ile  Lys His Gly 
        995                 1000                 1005             


Val Ile  Ile Ser Ser Thr Val  Asp Thr Tyr Glu Asn  Gly Ser Ser 
    1010                 1015                 1020             


Val Glu  Tyr Arg Cys Phe Asp  His His Phe Leu Glu  Gly Ser Arg 
    1025                 1030                 1035             


Glu Ala  Tyr Cys Leu Asp Gly  Met Trp Thr Thr Pro  Pro Leu Cys 
    1040                 1045                 1050             


Leu Glu  Pro Cys Thr Leu Ser  Phe Thr Glu Met Glu  Lys Asn Asn 
    1055                 1060                 1065             


Leu Leu  Leu Lys Trp Asp Phe  Asp Asn Arg Pro His  Ile Leu His 
    1070                 1075                 1080             


Gly Glu  Tyr Ile Glu Phe Ile  Cys Arg Gly Asp Thr  Tyr Pro Ala 
    1085                 1090                 1095             


Glu Leu  Tyr Ile Thr Gly Ser  Ile Leu Arg Met Gln  Cys Asp Arg 
    1100                 1105                 1110             


Gly Gln  Leu Lys Tyr Pro Arg  Cys Ile Pro Arg Gln  Ser Thr Leu 
    1115                 1120                 1125             


Ser Tyr  Gln Glu Pro Leu Arg  Thr 
    1130                 1135     


<210>  22
<211>  1090
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protine de fusion FIX-LXa-FXIIIB avec linker peptidique clivable
       comprenant TRIEGRIV, sans propeptide et sans peptide signal

<400>  22

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Thr 
                405                 410                 415     


Arg Ile Glu Gly Arg Ile Val Ser Ser Gly Gly Ser Gly Gly Ser Gly 
            420                 425                 430         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Ala Ala Ala 
        435                 440                 445             


Met Glu Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn Gly Arg Ile 
    450                 455                 460                 


Ala Gln Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro Met Ser Ile 
465                 470                 475                 480 


Asp Lys Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr Thr Glu Ser 
                485                 490                 495     


Gly Arg Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly Trp Ser Pro 
            500                 505                 510         


Glu Pro Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu Ser Asn Gly 
        515                 520                 525             


Tyr Ile Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu Asn Met His 
    530                 535                 540                 


Tyr Gly Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys Asp Glu Glu 
545                 550                 555                 560 


Val Val Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro Thr Cys Arg 
                565                 570                 575     


Lys Glu His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn Gly Asn Tyr 
            580                 585                 590         


Ser Thr Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val Gln Tyr Glu 
        595                 600                 605             


Cys Ala Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr Glu Glu Val 
    610                 615                 620                 


Glu Cys Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys Thr Lys Leu 
625                 630                 635                 640 


Lys Cys Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe His Pro Val 
                645                 650                 655     


Lys Gln Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe Cys His Glu 
            660                 665                 670         


Asn Tyr Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr Asn Phe Gly 
        675                 680                 685             


Trp Tyr Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn Arg Cys Pro 
    690                 695                 700                 


Pro Pro Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His Ser Thr Thr 
705                 710                 715                 720 


Tyr Arg His Gly Glu Ile Val His Ile Glu Cys Glu Leu Asn Phe Glu 
                725                 730                 735     


Ile His Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys Trp Thr Glu 
            740                 745                 750         


Pro Pro Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys Glu Glu Pro 
        755                 760                 765             


Pro Phe Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys Ile Tyr Tyr 
    770                 775                 780                 


Asn Gly Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr Leu Leu His 
785                 790                 795                 800 


Gly Ser Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr Leu Pro Pro 
                805                 810                 815     


Glu Cys Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro Val Val Met 
            820                 825                 830         


Asn Gly Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala Thr Gly Ser 
        835                 840                 845             


Ser Val Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg Gly Ser Lys 
    850                 855                 860                 


Ile Ser Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro Val Cys Leu 
865                 870                 875                 880 


Glu Pro Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn Asn Ile Glu 
                885                 890                 895     


Met Lys Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp Leu Ile Asp 
            900                 905                 910         


Phe Val Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr Pro Leu Ser 
        915                 920                 925             


Glu Leu Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr Pro Leu Cys 
    930                 935                 940                 


Thr Arg Lys Glu Ser Lys Gly Met Cys Thr Ser Pro Pro Leu Ile Lys 
945                 950                 955                 960 


His Gly Val Ile Ile Ser Ser Thr Val Asp Thr Tyr Glu Asn Gly Ser 
                965                 970                 975     


Ser Val Glu Tyr Arg Cys Phe Asp His His Phe Leu Glu Gly Ser Arg 
            980                 985                 990         


Glu Ala Tyr Cys Leu Asp Gly Met  Trp Thr Thr Pro Pro  Leu Cys Leu 
        995                 1000                 1005             


Glu Pro  Cys Thr Leu Ser Phe  Thr Glu Met Glu Lys  Asn Asn Leu 
    1010                 1015                 1020             


Leu Leu  Lys Trp Asp Phe Asp  Asn Arg Pro His Ile  Leu His Gly 
    1025                 1030                 1035             


Glu Tyr  Ile Glu Phe Ile Cys  Arg Gly Asp Thr Tyr  Pro Ala Glu 
    1040                 1045                 1050             


Leu Tyr  Ile Thr Gly Ser Ile  Leu Arg Met Gln Cys  Asp Arg Gly 
    1055                 1060                 1065             


Gln Leu  Lys Tyr Pro Arg Cys  Ile Pro Arg Gln Ser  Thr Leu Ser 
    1070                 1075                 1080             


Tyr Gln  Glu Pro Leu Arg Thr  
    1085                 1090 


<210>  23
<211>  1134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protine de fusion FIX-LIIa-FXIIIB avec linker peptidique 
       clivable comprenant GPRSFL, avec propeptide et avec peptide 
       signal

<400>  23

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Gly Pro Arg 
    450                 455                 460                 


Ser Phe Leu Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Gly Gly Ser Gly Ser Ala Ala Ala Met Glu Glu Lys 
                485                 490                 495     


Pro Cys Gly Phe Pro His Val Glu Asn Gly Arg Ile Ala Gln Tyr Tyr 
            500                 505                 510         


Tyr Thr Phe Lys Ser Phe Tyr Phe Pro Met Ser Ile Asp Lys Lys Leu 
        515                 520                 525             


Ser Phe Phe Cys Leu Ala Gly Tyr Thr Thr Glu Ser Gly Arg Gln Glu 
    530                 535                 540                 


Glu Gln Thr Thr Cys Thr Thr Glu Gly Trp Ser Pro Glu Pro Arg Cys 
545                 550                 555                 560 


Phe Lys Lys Cys Thr Lys Pro Asp Leu Ser Asn Gly Tyr Ile Ser Asp 
                565                 570                 575     


Val Lys Leu Leu Tyr Lys Ile Gln Glu Asn Met His Tyr Gly Cys Ala 
            580                 585                 590         


Ser Gly Tyr Lys Thr Thr Gly Gly Lys Asp Glu Glu Val Val Gln Cys 
        595                 600                 605             


Leu Ser Asp Gly Trp Ser Ser Gln Pro Thr Cys Arg Lys Glu His Glu 
    610                 615                 620                 


Thr Cys Leu Ala Pro Glu Leu Tyr Asn Gly Asn Tyr Ser Thr Thr Gln 
625                 630                 635                 640 


Lys Thr Phe Lys Val Lys Asp Lys Val Gln Tyr Glu Cys Ala Thr Gly 
                645                 650                 655     


Tyr Tyr Thr Ala Gly Gly Lys Lys Thr Glu Glu Val Glu Cys Leu Thr 
            660                 665                 670         


Tyr Gly Trp Ser Leu Thr Pro Lys Cys Thr Lys Leu Lys Cys Ser Ser 
        675                 680                 685             


Leu Arg Leu Ile Glu Asn Gly Tyr Phe His Pro Val Lys Gln Thr Tyr 
    690                 695                 700                 


Glu Glu Gly Asp Val Val Gln Phe Phe Cys His Glu Asn Tyr Tyr Leu 
705                 710                 715                 720 


Ser Gly Ser Asp Leu Ile Gln Cys Tyr Asn Phe Gly Trp Tyr Pro Glu 
                725                 730                 735     


Ser Pro Val Cys Glu Gly Arg Arg Asn Arg Cys Pro Pro Pro Pro Leu 
            740                 745                 750         


Pro Ile Asn Ser Lys Ile Gln Thr His Ser Thr Thr Tyr Arg His Gly 
        755                 760                 765             


Glu Ile Val His Ile Glu Cys Glu Leu Asn Phe Glu Ile His Gly Ser 
    770                 775                 780                 


Ala Glu Ile Arg Cys Glu Asp Gly Lys Trp Thr Glu Pro Pro Lys Cys 
785                 790                 795                 800 


Ile Glu Gly Gln Glu Lys Val Ala Cys Glu Glu Pro Pro Phe Ile Glu 
                805                 810                 815     


Asn Gly Ala Ala Asn Leu His Ser Lys Ile Tyr Tyr Asn Gly Asp Lys 
            820                 825                 830         


Val Thr Tyr Ala Cys Lys Ser Gly Tyr Leu Leu His Gly Ser Asn Glu 
        835                 840                 845             


Ile Thr Cys Asn Arg Gly Lys Trp Thr Leu Pro Pro Glu Cys Val Glu 
    850                 855                 860                 


Asn Asn Glu Asn Cys Lys His Pro Pro Val Val Met Asn Gly Ala Val 
865                 870                 875                 880 


Ala Asp Gly Ile Leu Ala Ser Tyr Ala Thr Gly Ser Ser Val Glu Tyr 
                885                 890                 895     


Arg Cys Asn Glu Tyr Tyr Leu Leu Arg Gly Ser Lys Ile Ser Arg Cys 
            900                 905                 910         


Glu Gln Gly Lys Trp Ser Ser Pro Pro Val Cys Leu Glu Pro Cys Thr 
        915                 920                 925             


Val Asn Val Asp Tyr Met Asn Arg Asn Asn Ile Glu Met Lys Trp Lys 
    930                 935                 940                 


Tyr Glu Gly Lys Val Leu His Gly Asp Leu Ile Asp Phe Val Cys Lys 
945                 950                 955                 960 


Gln Gly Tyr Asp Leu Ser Pro Leu Thr Pro Leu Ser Glu Leu Ser Val 
                965                 970                 975     


Gln Cys Asn Arg Gly Glu Val Lys Tyr Pro Leu Cys Thr Arg Lys Glu 
            980                 985                 990         


Ser Lys Gly Met Cys Thr Ser Pro  Pro Leu Ile Lys His  Gly Val Ile 
        995                 1000                 1005             


Ile Ser  Ser Thr Val Asp Thr  Tyr Glu Asn Gly Ser  Ser Val Glu 
    1010                 1015                 1020             


Tyr Arg  Cys Phe Asp His His  Phe Leu Glu Gly Ser  Arg Glu Ala 
    1025                 1030                 1035             


Tyr Cys  Leu Asp Gly Met Trp  Thr Thr Pro Pro Leu  Cys Leu Glu 
    1040                 1045                 1050             


Pro Cys  Thr Leu Ser Phe Thr  Glu Met Glu Lys Asn  Asn Leu Leu 
    1055                 1060                 1065             


Leu Lys  Trp Asp Phe Asp Asn  Arg Pro His Ile Leu  His Gly Glu 
    1070                 1075                 1080             


Tyr Ile  Glu Phe Ile Cys Arg  Gly Asp Thr Tyr Pro  Ala Glu Leu 
    1085                 1090                 1095             


Tyr Ile  Thr Gly Ser Ile Leu  Arg Met Gln Cys Asp  Arg Gly Gln 
    1100                 1105                 1110             


Leu Lys  Tyr Pro Arg Cys Ile  Pro Arg Gln Ser Thr  Leu Ser Tyr 
    1115                 1120                 1125             


Gln Glu  Pro Leu Arg Thr 
    1130                 


<210>  24
<211>  1088
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protine de fusion FIX-LIIa-FXIIIB avec linker peptidique 
       clivable comprenant GPRSFL, sans propeptide et sans peptide 
       signal

<400>  24

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Gly 
                405                 410                 415     


Pro Arg Ser Phe Leu Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            420                 425                 430         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Ala Ala Ala Met Glu 
        435                 440                 445             


Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn Gly Arg Ile Ala Gln 
    450                 455                 460                 


Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro Met Ser Ile Asp Lys 
465                 470                 475                 480 


Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr Thr Glu Ser Gly Arg 
                485                 490                 495     


Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly Trp Ser Pro Glu Pro 
            500                 505                 510         


Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu Ser Asn Gly Tyr Ile 
        515                 520                 525             


Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu Asn Met His Tyr Gly 
    530                 535                 540                 


Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys Asp Glu Glu Val Val 
545                 550                 555                 560 


Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro Thr Cys Arg Lys Glu 
                565                 570                 575     


His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn Gly Asn Tyr Ser Thr 
            580                 585                 590         


Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val Gln Tyr Glu Cys Ala 
        595                 600                 605             


Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr Glu Glu Val Glu Cys 
    610                 615                 620                 


Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys Thr Lys Leu Lys Cys 
625                 630                 635                 640 


Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe His Pro Val Lys Gln 
                645                 650                 655     


Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe Cys His Glu Asn Tyr 
            660                 665                 670         


Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr Asn Phe Gly Trp Tyr 
        675                 680                 685             


Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn Arg Cys Pro Pro Pro 
    690                 695                 700                 


Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His Ser Thr Thr Tyr Arg 
705                 710                 715                 720 


His Gly Glu Ile Val His Ile Glu Cys Glu Leu Asn Phe Glu Ile His 
                725                 730                 735     


Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys Trp Thr Glu Pro Pro 
            740                 745                 750         


Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys Glu Glu Pro Pro Phe 
        755                 760                 765             


Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys Ile Tyr Tyr Asn Gly 
    770                 775                 780                 


Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr Leu Leu His Gly Ser 
785                 790                 795                 800 


Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr Leu Pro Pro Glu Cys 
                805                 810                 815     


Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro Val Val Met Asn Gly 
            820                 825                 830         


Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala Thr Gly Ser Ser Val 
        835                 840                 845             


Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg Gly Ser Lys Ile Ser 
    850                 855                 860                 


Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro Val Cys Leu Glu Pro 
865                 870                 875                 880 


Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn Asn Ile Glu Met Lys 
                885                 890                 895     


Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp Leu Ile Asp Phe Val 
            900                 905                 910         


Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr Pro Leu Ser Glu Leu 
        915                 920                 925             


Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr Pro Leu Cys Thr Arg 
    930                 935                 940                 


Lys Glu Ser Lys Gly Met Cys Thr Ser Pro Pro Leu Ile Lys His Gly 
945                 950                 955                 960 


Val Ile Ile Ser Ser Thr Val Asp Thr Tyr Glu Asn Gly Ser Ser Val 
                965                 970                 975     


Glu Tyr Arg Cys Phe Asp His His Phe Leu Glu Gly Ser Arg Glu Ala 
            980                 985                 990         


Tyr Cys Leu Asp Gly Met Trp Thr  Thr Pro Pro Leu Cys  Leu Glu Pro 
        995                 1000                 1005             


Cys Thr  Leu Ser Phe Thr Glu  Met Glu Lys Asn Asn  Leu Leu Leu 
    1010                 1015                 1020             


Lys Trp  Asp Phe Asp Asn Arg  Pro His Ile Leu His  Gly Glu Tyr 
    1025                 1030                 1035             


Ile Glu  Phe Ile Cys Arg Gly  Asp Thr Tyr Pro Ala  Glu Leu Tyr 
    1040                 1045                 1050             


Ile Thr  Gly Ser Ile Leu Arg  Met Gln Cys Asp Arg  Gly Gln Leu 
    1055                 1060                 1065             


Lys Tyr  Pro Arg Cys Ile Pro  Arg Gln Ser Thr Leu  Ser Tyr Gln 
    1070                 1075                 1080             


Glu Pro  Leu Arg Thr 
    1085             


                         
<210>  25
<211>  1136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIXE410H-LXa-FXIIIB

<400>  25

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys His Lys Thr Lys Leu Thr Thr Arg Ile 
    450                 455                 460                 


Glu Gly Arg Ile Val Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Ala Ala Ala Met Glu 
                485                 490                 495     


Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn Gly Arg Ile Ala Gln 
            500                 505                 510         


Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro Met Ser Ile Asp Lys 
        515                 520                 525             


Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr Thr Glu Ser Gly Arg 
    530                 535                 540                 


Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly Trp Ser Pro Glu Pro 
545                 550                 555                 560 


Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu Ser Asn Gly Tyr Ile 
                565                 570                 575     


Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu Asn Met His Tyr Gly 
            580                 585                 590         


Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys Asp Glu Glu Val Val 
        595                 600                 605             


Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro Thr Cys Arg Lys Glu 
    610                 615                 620                 


His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn Gly Asn Tyr Ser Thr 
625                 630                 635                 640 


Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val Gln Tyr Glu Cys Ala 
                645                 650                 655     


Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr Glu Glu Val Glu Cys 
            660                 665                 670         


Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys Thr Lys Leu Lys Cys 
        675                 680                 685             


Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe His Pro Val Lys Gln 
    690                 695                 700                 


Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe Cys His Glu Asn Tyr 
705                 710                 715                 720 


Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr Asn Phe Gly Trp Tyr 
                725                 730                 735     


Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn Arg Cys Pro Pro Pro 
            740                 745                 750         


Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His Ser Thr Thr Tyr Arg 
        755                 760                 765             


His Gly Glu Ile Val His Ile Glu Cys Glu Leu Asn Phe Glu Ile His 
    770                 775                 780                 


Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys Trp Thr Glu Pro Pro 
785                 790                 795                 800 


Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys Glu Glu Pro Pro Phe 
                805                 810                 815     


Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys Ile Tyr Tyr Asn Gly 
            820                 825                 830         


Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr Leu Leu His Gly Ser 
        835                 840                 845             


Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr Leu Pro Pro Glu Cys 
    850                 855                 860                 


Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro Val Val Met Asn Gly 
865                 870                 875                 880 


Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala Thr Gly Ser Ser Val 
                885                 890                 895     


Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg Gly Ser Lys Ile Ser 
            900                 905                 910         


Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro Val Cys Leu Glu Pro 
        915                 920                 925             


Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn Asn Ile Glu Met Lys 
    930                 935                 940                 


Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp Leu Ile Asp Phe Val 
945                 950                 955                 960 


Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr Pro Leu Ser Glu Leu 
                965                 970                 975     


Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr Pro Leu Cys Thr Arg 
            980                 985                 990         


Lys Glu Ser Lys Gly Met Cys Thr  Ser Pro Pro Leu Ile  Lys His Gly 
        995                 1000                 1005             


Val Ile  Ile Ser Ser Thr Val  Asp Thr Tyr Glu Asn  Gly Ser Ser 
    1010                 1015                 1020             


Val Glu  Tyr Arg Cys Phe Asp  His His Phe Leu Glu  Gly Ser Arg 
    1025                 1030                 1035             


Glu Ala  Tyr Cys Leu Asp Gly  Met Trp Thr Thr Pro  Pro Leu Cys 
    1040                 1045                 1050             


Leu Glu  Pro Cys Thr Leu Ser  Phe Thr Glu Met Glu  Lys Asn Asn 
    1055                 1060                 1065             


Leu Leu  Leu Lys Trp Asp Phe  Asp Asn Arg Pro His  Ile Leu His 
    1070                 1075                 1080             


Gly Glu  Tyr Ile Glu Phe Ile  Cys Arg Gly Asp Thr  Tyr Pro Ala 
    1085                 1090                 1095             


Glu Leu  Tyr Ile Thr Gly Ser  Ile Leu Arg Met Gln  Cys Asp Arg 
    1100                 1105                 1110             


Gly Gln  Leu Lys Tyr Pro Arg  Cys Ile Pro Arg Gln  Ser Thr Leu 
    1115                 1120                 1125             


Ser Tyr  Gln Glu Pro Leu Arg  Thr 
    1130                 1135     


<210>  26
<211>  1136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIXE410H-LIIA-FXIIIB

<400>  26

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys His Lys Thr Lys Leu Thr Thr Arg Gly 
    450                 455                 460                 


Pro Arg Ser Phe Leu Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Ala Ala Ala Met Glu 
                485                 490                 495     


Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn Gly Arg Ile Ala Gln 
            500                 505                 510         


Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro Met Ser Ile Asp Lys 
        515                 520                 525             


Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr Thr Glu Ser Gly Arg 
    530                 535                 540                 


Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly Trp Ser Pro Glu Pro 
545                 550                 555                 560 


Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu Ser Asn Gly Tyr Ile 
                565                 570                 575     


Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu Asn Met His Tyr Gly 
            580                 585                 590         


Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys Asp Glu Glu Val Val 
        595                 600                 605             


Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro Thr Cys Arg Lys Glu 
    610                 615                 620                 


His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn Gly Asn Tyr Ser Thr 
625                 630                 635                 640 


Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val Gln Tyr Glu Cys Ala 
                645                 650                 655     


Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr Glu Glu Val Glu Cys 
            660                 665                 670         


Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys Thr Lys Leu Lys Cys 
        675                 680                 685             


Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe His Pro Val Lys Gln 
    690                 695                 700                 


Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe Cys His Glu Asn Tyr 
705                 710                 715                 720 


Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr Asn Phe Gly Trp Tyr 
                725                 730                 735     


Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn Arg Cys Pro Pro Pro 
            740                 745                 750         


Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His Ser Thr Thr Tyr Arg 
        755                 760                 765             


His Gly Glu Ile Val His Ile Glu Cys Glu Leu Asn Phe Glu Ile His 
    770                 775                 780                 


Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys Trp Thr Glu Pro Pro 
785                 790                 795                 800 


Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys Glu Glu Pro Pro Phe 
                805                 810                 815     


Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys Ile Tyr Tyr Asn Gly 
            820                 825                 830         


Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr Leu Leu His Gly Ser 
        835                 840                 845             


Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr Leu Pro Pro Glu Cys 
    850                 855                 860                 


Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro Val Val Met Asn Gly 
865                 870                 875                 880 


Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala Thr Gly Ser Ser Val 
                885                 890                 895     


Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg Gly Ser Lys Ile Ser 
            900                 905                 910         


Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro Val Cys Leu Glu Pro 
        915                 920                 925             


Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn Asn Ile Glu Met Lys 
    930                 935                 940                 


Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp Leu Ile Asp Phe Val 
945                 950                 955                 960 


Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr Pro Leu Ser Glu Leu 
                965                 970                 975     


Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr Pro Leu Cys Thr Arg 
            980                 985                 990         


Lys Glu Ser Lys Gly Met Cys Thr  Ser Pro Pro Leu Ile  Lys His Gly 
        995                 1000                 1005             


Val Ile  Ile Ser Ser Thr Val  Asp Thr Tyr Glu Asn  Gly Ser Ser 
    1010                 1015                 1020             


Val Glu  Tyr Arg Cys Phe Asp  His His Phe Leu Glu  Gly Ser Arg 
    1025                 1030                 1035             


Glu Ala  Tyr Cys Leu Asp Gly  Met Trp Thr Thr Pro  Pro Leu Cys 
    1040                 1045                 1050             


Leu Glu  Pro Cys Thr Leu Ser  Phe Thr Glu Met Glu  Lys Asn Asn 
    1055                 1060                 1065             


Leu Leu  Leu Lys Trp Asp Phe  Asp Asn Arg Pro His  Ile Leu His 
    1070                 1075                 1080             


Gly Glu  Tyr Ile Glu Phe Ile  Cys Arg Gly Asp Thr  Tyr Pro Ala 
    1085                 1090                 1095             


Glu Leu  Tyr Ile Thr Gly Ser  Ile Leu Arg Met Gln  Cys Asp Arg 
    1100                 1105                 1110             


Gly Gln  Leu Lys Tyr Pro Arg  Cys Ile Pro Arg Gln  Ser Thr Leu 
    1115                 1120                 1125             


Ser Tyr  Gln Glu Pro Leu Arg  Thr 
    1130                 1135     


<210>  27
<211>  2122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-LXA-FXIIIB

<400>  27

Met Glu Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Arg Arg Arg Arg Glu Ile Thr Arg Thr 
        755                 760                 765             


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
    770                 775                 780                 


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
785                 790                 795                 800 


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
                805                 810                 815     


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
            820                 825                 830         


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
        835                 840                 845             


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
    850                 855                 860                 


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
865                 870                 875                 880 


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
                885                 890                 895     


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
            900                 905                 910         


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
        915                 920                 925             


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
    930                 935                 940                 


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
945                 950                 955                 960 


Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn 
                965                 970                 975     


Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala 
            980                 985                 990         


Leu Phe Phe Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
        995                 1000                 1005             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1010                 1015                 1020             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1025                 1030                 1035             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1040                 1045                 1050             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1055                 1060                 1065             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1070                 1075                 1080             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1085                 1090                 1095             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1100                 1105                 1110             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    1115                 1120                 1125             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    1130                 1135                 1140             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    1145                 1150                 1155             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    1160                 1165                 1170             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    1175                 1180                 1185             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    1190                 1195                 1200             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    1205                 1210                 1215             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    1220                 1225                 1230             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    1235                 1240                 1245             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    1250                 1255                 1260             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    1265                 1270                 1275             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    1280                 1285                 1290             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    1295                 1300                 1305             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    1310                 1315                 1320             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    1325                 1330                 1335             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    1340                 1345                 1350             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    1355                 1360                 1365             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    1370                 1375                 1380             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    1385                 1390                 1395             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    1400                 1405                 1410             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    1415                 1420                 1425             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    1430                 1435                 1440             


Gln Asp  Leu Tyr Thr Arg Ile  Glu Gly Arg Ile Val  Ser Ser Gly 
    1445                 1450                 1455             


Gly Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1460                 1465                 1470             


Gly Ser  Gly Ser Ala Ala Ala  Met Glu Glu Lys Pro  Cys Gly Phe 
    1475                 1480                 1485             


Pro His  Val Glu Asn Gly Arg  Ile Ala Gln Tyr Tyr  Tyr Thr Phe 
    1490                 1495                 1500             


Lys Ser  Phe Tyr Phe Pro Met  Ser Ile Asp Lys Lys  Leu Ser Phe 
    1505                 1510                 1515             


Phe Cys  Leu Ala Gly Tyr Thr  Thr Glu Ser Gly Arg  Gln Glu Glu 
    1520                 1525                 1530             


Gln Thr  Thr Cys Thr Thr Glu  Gly Trp Ser Pro Glu  Pro Arg Cys 
    1535                 1540                 1545             


Phe Lys  Lys Cys Thr Lys Pro  Asp Leu Ser Asn Gly  Tyr Ile Ser 
    1550                 1555                 1560             


Asp Val  Lys Leu Leu Tyr Lys  Ile Gln Glu Asn Met  His Tyr Gly 
    1565                 1570                 1575             


Cys Ala  Ser Gly Tyr Lys Thr  Thr Gly Gly Lys Asp  Glu Glu Val 
    1580                 1585                 1590             


Val Gln  Cys Leu Ser Asp Gly  Trp Ser Ser Gln Pro  Thr Cys Arg 
    1595                 1600                 1605             


Lys Glu  His Glu Thr Cys Leu  Ala Pro Glu Leu Tyr  Asn Gly Asn 
    1610                 1615                 1620             


Tyr Ser  Thr Thr Gln Lys Thr  Phe Lys Val Lys Asp  Lys Val Gln 
    1625                 1630                 1635             


Tyr Glu  Cys Ala Thr Gly Tyr  Tyr Thr Ala Gly Gly  Lys Lys Thr 
    1640                 1645                 1650             


Glu Glu  Val Glu Cys Leu Thr  Tyr Gly Trp Ser Leu  Thr Pro Lys 
    1655                 1660                 1665             


Cys Thr  Lys Leu Lys Cys Ser  Ser Leu Arg Leu Ile  Glu Asn Gly 
    1670                 1675                 1680             


Tyr Phe  His Pro Val Lys Gln  Thr Tyr Glu Glu Gly  Asp Val Val 
    1685                 1690                 1695             


Gln Phe  Phe Cys His Glu Asn  Tyr Tyr Leu Ser Gly  Ser Asp Leu 
    1700                 1705                 1710             


Ile Gln  Cys Tyr Asn Phe Gly  Trp Tyr Pro Glu Ser  Pro Val Cys 
    1715                 1720                 1725             


Glu Gly  Arg Arg Asn Arg Cys  Pro Pro Pro Pro Leu  Pro Ile Asn 
    1730                 1735                 1740             


Ser Lys  Ile Gln Thr His Ser  Thr Thr Tyr Arg His  Gly Glu Ile 
    1745                 1750                 1755             


Val His  Ile Glu Cys Glu Leu  Asn Phe Glu Ile His  Gly Ser Ala 
    1760                 1765                 1770             


Glu Ile  Arg Cys Glu Asp Gly  Lys Trp Thr Glu Pro  Pro Lys Cys 
    1775                 1780                 1785             


Ile Glu  Gly Gln Glu Lys Val  Ala Cys Glu Glu Pro  Pro Phe Ile 
    1790                 1795                 1800             


Glu Asn  Gly Ala Ala Asn Leu  His Ser Lys Ile Tyr  Tyr Asn Gly 
    1805                 1810                 1815             


Asp Lys  Val Thr Tyr Ala Cys  Lys Ser Gly Tyr Leu  Leu His Gly 
    1820                 1825                 1830             


Ser Asn  Glu Ile Thr Cys Asn  Arg Gly Lys Trp Thr  Leu Pro Pro 
    1835                 1840                 1845             


Glu Cys  Val Glu Asn Asn Glu  Asn Cys Lys His Pro  Pro Val Val 
    1850                 1855                 1860             


Met Asn  Gly Ala Val Ala Asp  Gly Ile Leu Ala Ser  Tyr Ala Thr 
    1865                 1870                 1875             


Gly Ser  Ser Val Glu Tyr Arg  Cys Asn Glu Tyr Tyr  Leu Leu Arg 
    1880                 1885                 1890             


Gly Ser  Lys Ile Ser Arg Cys  Glu Gln Gly Lys Trp  Ser Ser Pro 
    1895                 1900                 1905             


Pro Val  Cys Leu Glu Pro Cys  Thr Val Asn Val Asp  Tyr Met Asn 
    1910                 1915                 1920             


Arg Asn  Asn Ile Glu Met Lys  Trp Lys Tyr Glu Gly  Lys Val Leu 
    1925                 1930                 1935             


His Gly  Asp Leu Ile Asp Phe  Val Cys Lys Gln Gly  Tyr Asp Leu 
    1940                 1945                 1950             


Ser Pro  Leu Thr Pro Leu Ser  Glu Leu Ser Val Gln  Cys Asn Arg 
    1955                 1960                 1965             


Gly Glu  Val Lys Tyr Pro Leu  Cys Thr Arg Lys Glu  Ser Lys Gly 
    1970                 1975                 1980             


Met Cys  Thr Ser Pro Pro Leu  Ile Lys His Gly Val  Ile Ile Ser 
    1985                 1990                 1995             


Ser Thr  Val Asp Thr Tyr Glu  Asn Gly Ser Ser Val  Glu Tyr Arg 
    2000                 2005                 2010             


Cys Phe  Asp His His Phe Leu  Glu Gly Ser Arg Glu  Ala Tyr Cys 
    2015                 2020                 2025             


Leu Asp  Gly Met Trp Thr Thr  Pro Pro Leu Cys Leu  Glu Pro Cys 
    2030                 2035                 2040             


Thr Leu  Ser Phe Thr Glu Met  Glu Lys Asn Asn Leu  Leu Leu Lys 
    2045                 2050                 2055             


Trp Asp  Phe Asp Asn Arg Pro  His Ile Leu His Gly  Glu Tyr Ile 
    2060                 2065                 2070             


Glu Phe  Ile Cys Arg Gly Asp  Thr Tyr Pro Ala Glu  Leu Tyr Ile 
    2075                 2080                 2085             


Thr Gly  Ser Ile Leu Arg Met  Gln Cys Asp Arg Gly  Gln Leu Lys 
    2090                 2095                 2100             


Tyr Pro  Arg Cys Ile Pro Arg  Gln Ser Thr Leu Ser  Tyr Gln Glu 
    2105                 2110                 2115             


Pro Leu  Arg Thr 
    2120         


<210>  28
<211>  2122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-LIIA-FXIIIB

<400>  28

Met Glu Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Arg Arg Arg Arg Glu Ile Thr Arg Thr 
        755                 760                 765             


Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
    770                 775                 780                 


Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
785                 790                 795                 800 


Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
                805                 810                 815     


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
            820                 825                 830         


Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
        835                 840                 845             


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
    850                 855                 860                 


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
865                 870                 875                 880 


Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
                885                 890                 895     


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
            900                 905                 910         


Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
        915                 920                 925             


Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
    930                 935                 940                 


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
945                 950                 955                 960 


Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn 
                965                 970                 975     


Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala 
            980                 985                 990         


Leu Phe Phe Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
        995                 1000                 1005             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1010                 1015                 1020             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1025                 1030                 1035             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1040                 1045                 1050             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1055                 1060                 1065             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1070                 1075                 1080             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1085                 1090                 1095             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1100                 1105                 1110             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    1115                 1120                 1125             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    1130                 1135                 1140             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    1145                 1150                 1155             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    1160                 1165                 1170             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    1175                 1180                 1185             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    1190                 1195                 1200             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    1205                 1210                 1215             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    1220                 1225                 1230             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    1235                 1240                 1245             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    1250                 1255                 1260             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    1265                 1270                 1275             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    1280                 1285                 1290             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    1295                 1300                 1305             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    1310                 1315                 1320             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    1325                 1330                 1335             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    1340                 1345                 1350             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    1355                 1360                 1365             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    1370                 1375                 1380             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    1385                 1390                 1395             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    1400                 1405                 1410             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    1415                 1420                 1425             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    1430                 1435                 1440             


Gln Asp  Leu Tyr Thr Arg Gly  Pro Arg Ser Phe Leu  Ser Ser Gly 
    1445                 1450                 1455             


Gly Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1460                 1465                 1470             


Gly Ser  Gly Ser Ala Ala Ala  Met Glu Glu Lys Pro  Cys Gly Phe 
    1475                 1480                 1485             


Pro His  Val Glu Asn Gly Arg  Ile Ala Gln Tyr Tyr  Tyr Thr Phe 
    1490                 1495                 1500             


Lys Ser  Phe Tyr Phe Pro Met  Ser Ile Asp Lys Lys  Leu Ser Phe 
    1505                 1510                 1515             


Phe Cys  Leu Ala Gly Tyr Thr  Thr Glu Ser Gly Arg  Gln Glu Glu 
    1520                 1525                 1530             


Gln Thr  Thr Cys Thr Thr Glu  Gly Trp Ser Pro Glu  Pro Arg Cys 
    1535                 1540                 1545             


Phe Lys  Lys Cys Thr Lys Pro  Asp Leu Ser Asn Gly  Tyr Ile Ser 
    1550                 1555                 1560             


Asp Val  Lys Leu Leu Tyr Lys  Ile Gln Glu Asn Met  His Tyr Gly 
    1565                 1570                 1575             


Cys Ala  Ser Gly Tyr Lys Thr  Thr Gly Gly Lys Asp  Glu Glu Val 
    1580                 1585                 1590             


Val Gln  Cys Leu Ser Asp Gly  Trp Ser Ser Gln Pro  Thr Cys Arg 
    1595                 1600                 1605             


Lys Glu  His Glu Thr Cys Leu  Ala Pro Glu Leu Tyr  Asn Gly Asn 
    1610                 1615                 1620             


Tyr Ser  Thr Thr Gln Lys Thr  Phe Lys Val Lys Asp  Lys Val Gln 
    1625                 1630                 1635             


Tyr Glu  Cys Ala Thr Gly Tyr  Tyr Thr Ala Gly Gly  Lys Lys Thr 
    1640                 1645                 1650             


Glu Glu  Val Glu Cys Leu Thr  Tyr Gly Trp Ser Leu  Thr Pro Lys 
    1655                 1660                 1665             


Cys Thr  Lys Leu Lys Cys Ser  Ser Leu Arg Leu Ile  Glu Asn Gly 
    1670                 1675                 1680             


Tyr Phe  His Pro Val Lys Gln  Thr Tyr Glu Glu Gly  Asp Val Val 
    1685                 1690                 1695             


Gln Phe  Phe Cys His Glu Asn  Tyr Tyr Leu Ser Gly  Ser Asp Leu 
    1700                 1705                 1710             


Ile Gln  Cys Tyr Asn Phe Gly  Trp Tyr Pro Glu Ser  Pro Val Cys 
    1715                 1720                 1725             


Glu Gly  Arg Arg Asn Arg Cys  Pro Pro Pro Pro Leu  Pro Ile Asn 
    1730                 1735                 1740             


Ser Lys  Ile Gln Thr His Ser  Thr Thr Tyr Arg His  Gly Glu Ile 
    1745                 1750                 1755             


Val His  Ile Glu Cys Glu Leu  Asn Phe Glu Ile His  Gly Ser Ala 
    1760                 1765                 1770             


Glu Ile  Arg Cys Glu Asp Gly  Lys Trp Thr Glu Pro  Pro Lys Cys 
    1775                 1780                 1785             


Ile Glu  Gly Gln Glu Lys Val  Ala Cys Glu Glu Pro  Pro Phe Ile 
    1790                 1795                 1800             


Glu Asn  Gly Ala Ala Asn Leu  His Ser Lys Ile Tyr  Tyr Asn Gly 
    1805                 1810                 1815             


Asp Lys  Val Thr Tyr Ala Cys  Lys Ser Gly Tyr Leu  Leu His Gly 
    1820                 1825                 1830             


Ser Asn  Glu Ile Thr Cys Asn  Arg Gly Lys Trp Thr  Leu Pro Pro 
    1835                 1840                 1845             


Glu Cys  Val Glu Asn Asn Glu  Asn Cys Lys His Pro  Pro Val Val 
    1850                 1855                 1860             


Met Asn  Gly Ala Val Ala Asp  Gly Ile Leu Ala Ser  Tyr Ala Thr 
    1865                 1870                 1875             


Gly Ser  Ser Val Glu Tyr Arg  Cys Asn Glu Tyr Tyr  Leu Leu Arg 
    1880                 1885                 1890             


Gly Ser  Lys Ile Ser Arg Cys  Glu Gln Gly Lys Trp  Ser Ser Pro 
    1895                 1900                 1905             


Pro Val  Cys Leu Glu Pro Cys  Thr Val Asn Val Asp  Tyr Met Asn 
    1910                 1915                 1920             


Arg Asn  Asn Ile Glu Met Lys  Trp Lys Tyr Glu Gly  Lys Val Leu 
    1925                 1930                 1935             


His Gly  Asp Leu Ile Asp Phe  Val Cys Lys Gln Gly  Tyr Asp Leu 
    1940                 1945                 1950             


Ser Pro  Leu Thr Pro Leu Ser  Glu Leu Ser Val Gln  Cys Asn Arg 
    1955                 1960                 1965             


Gly Glu  Val Lys Tyr Pro Leu  Cys Thr Arg Lys Glu  Ser Lys Gly 
    1970                 1975                 1980             


Met Cys  Thr Ser Pro Pro Leu  Ile Lys His Gly Val  Ile Ile Ser 
    1985                 1990                 1995             


Ser Thr  Val Asp Thr Tyr Glu  Asn Gly Ser Ser Val  Glu Tyr Arg 
    2000                 2005                 2010             


Cys Phe  Asp His His Phe Leu  Glu Gly Ser Arg Glu  Ala Tyr Cys 
    2015                 2020                 2025             


Leu Asp  Gly Met Trp Thr Thr  Pro Pro Leu Cys Leu  Glu Pro Cys 
    2030                 2035                 2040             


Thr Leu  Ser Phe Thr Glu Met  Glu Lys Asn Asn Leu  Leu Leu Lys 
    2045                 2050                 2055             


Trp Asp  Phe Asp Asn Arg Pro  His Ile Leu His Gly  Glu Tyr Ile 
    2060                 2065                 2070             


Glu Phe  Ile Cys Arg Gly Asp  Thr Tyr Pro Ala Glu  Leu Tyr Ile 
    2075                 2080                 2085             


Thr Gly  Ser Ile Leu Arg Met  Gln Cys Asp Arg Gly  Gln Leu Lys 
    2090                 2095                 2100             


Tyr Pro  Arg Cys Ile Pro Arg  Gln Ser Thr Leu Ser  Tyr Gln Glu 
    2105                 2110                 2115             


Pro Leu  Arg Thr 
    2120         


<210>  29
<211>  2088
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII-FXIIIB sans linker peptidique 
       clivable 

<400>  29

Met Glu Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Glu Glu Lys Pro Cys Gly Phe Pro His 
        755                 760                 765             


Val Glu Asn Gly Arg Ile Ala Gln Tyr Tyr Tyr Thr Phe Lys Ser Phe 
    770                 775                 780                 


Tyr Phe Pro Met Ser Ile Asp Lys Lys Leu Ser Phe Phe Cys Leu Ala 
785                 790                 795                 800 


Gly Tyr Thr Thr Glu Ser Gly Arg Gln Glu Glu Gln Thr Thr Cys Thr 
                805                 810                 815     


Thr Glu Gly Trp Ser Pro Glu Pro Arg Cys Phe Lys Lys Cys Thr Lys 
            820                 825                 830         


Pro Asp Leu Ser Asn Gly Tyr Ile Ser Asp Val Lys Leu Leu Tyr Lys 
        835                 840                 845             


Ile Gln Glu Asn Met His Tyr Gly Cys Ala Ser Gly Tyr Lys Thr Thr 
    850                 855                 860                 


Gly Gly Lys Asp Glu Glu Val Val Gln Cys Leu Ser Asp Gly Trp Ser 
865                 870                 875                 880 


Ser Gln Pro Thr Cys Arg Lys Glu His Glu Thr Cys Leu Ala Pro Glu 
                885                 890                 895     


Leu Tyr Asn Gly Asn Tyr Ser Thr Thr Gln Lys Thr Phe Lys Val Lys 
            900                 905                 910         


Asp Lys Val Gln Tyr Glu Cys Ala Thr Gly Tyr Tyr Thr Ala Gly Gly 
        915                 920                 925             


Lys Lys Thr Glu Glu Val Glu Cys Leu Thr Tyr Gly Trp Ser Leu Thr 
    930                 935                 940                 


Pro Lys Cys Thr Lys Leu Lys Cys Ser Ser Leu Arg Leu Ile Glu Asn 
945                 950                 955                 960 


Gly Tyr Phe His Pro Val Lys Gln Thr Tyr Glu Glu Gly Asp Val Val 
                965                 970                 975     


Gln Phe Phe Cys His Glu Asn Tyr Tyr Leu Ser Gly Ser Asp Leu Ile 
            980                 985                 990         


Gln Cys Tyr Asn Phe Gly Trp Tyr  Pro Glu Ser Pro Val  Cys Glu Gly 
        995                 1000                 1005             


Arg Arg  Asn Arg Cys Pro Pro  Pro Pro Leu Pro Ile  Asn Ser Lys 
    1010                 1015                 1020             


Ile Gln  Thr His Ser Thr Thr  Tyr Arg His Gly Glu  Ile Val His 
    1025                 1030                 1035             


Ile Glu  Cys Glu Leu Asn Phe  Glu Ile His Gly Ser  Ala Glu Ile 
    1040                 1045                 1050             


Arg Cys  Glu Asp Gly Lys Trp  Thr Glu Pro Pro Lys  Cys Ile Glu 
    1055                 1060                 1065             


Gly Gln  Glu Lys Val Ala Cys  Glu Glu Pro Pro Phe  Ile Glu Asn 
    1070                 1075                 1080             


Gly Ala  Ala Asn Leu His Ser  Lys Ile Tyr Tyr Asn  Gly Asp Lys 
    1085                 1090                 1095             


Val Thr  Tyr Ala Cys Lys Ser  Gly Tyr Leu Leu His  Gly Ser Asn 
    1100                 1105                 1110             


Glu Ile  Thr Cys Asn Arg Gly  Lys Trp Thr Leu Pro  Pro Glu Cys 
    1115                 1120                 1125             


Val Glu  Asn Asn Glu Asn Cys  Lys His Pro Pro Val  Val Met Asn 
    1130                 1135                 1140             


Gly Ala  Val Ala Asp Gly Ile  Leu Ala Ser Tyr Ala  Thr Gly Ser 
    1145                 1150                 1155             


Ser Val  Glu Tyr Arg Cys Asn  Glu Tyr Tyr Leu Leu  Arg Gly Ser 
    1160                 1165                 1170             


Lys Ile  Ser Arg Cys Glu Gln  Gly Lys Trp Ser Ser  Pro Pro Val 
    1175                 1180                 1185             


Cys Leu  Glu Pro Cys Thr Val  Asn Val Asp Tyr Met  Asn Arg Asn 
    1190                 1195                 1200             


Asn Ile  Glu Met Lys Trp Lys  Tyr Glu Gly Lys Val  Leu His Gly 
    1205                 1210                 1215             


Asp Leu  Ile Asp Phe Val Cys  Lys Gln Gly Tyr Asp  Leu Ser Pro 
    1220                 1225                 1230             


Leu Thr  Pro Leu Ser Glu Leu  Ser Val Gln Cys Asn  Arg Gly Glu 
    1235                 1240                 1245             


Val Lys  Tyr Pro Leu Cys Thr  Arg Lys Glu Ser Lys  Gly Met Cys 
    1250                 1255                 1260             


Thr Ser  Pro Pro Leu Ile Lys  His Gly Val Ile Ile  Ser Ser Thr 
    1265                 1270                 1275             


Val Asp  Thr Tyr Glu Asn Gly  Ser Ser Val Glu Tyr  Arg Cys Phe 
    1280                 1285                 1290             


Asp His  His Phe Leu Glu Gly  Ser Arg Glu Ala Tyr  Cys Leu Asp 
    1295                 1300                 1305             


Gly Met  Trp Thr Thr Pro Pro  Leu Cys Leu Glu Pro  Cys Thr Leu 
    1310                 1315                 1320             


Ser Phe  Thr Glu Met Glu Lys  Asn Asn Leu Leu Leu  Lys Trp Asp 
    1325                 1330                 1335             


Phe Asp  Asn Arg Pro His Ile  Leu His Gly Glu Tyr  Ile Glu Phe 
    1340                 1345                 1350             


Ile Cys  Arg Gly Asp Thr Tyr  Pro Ala Glu Leu Tyr  Ile Thr Gly 
    1355                 1360                 1365             


Ser Ile  Leu Arg Met Gln Cys  Asp Arg Gly Gln Leu  Lys Tyr Pro 
    1370                 1375                 1380             


Arg Cys  Ile Pro Arg Gln Ser  Thr Leu Ser Tyr Gln  Glu Pro Leu 
    1385                 1390                 1395             


Arg Thr  Arg Arg Arg Arg Glu  Ile Thr Arg Thr Thr  Leu Gln Ser 
    1400                 1405                 1410             


Asp Gln  Glu Glu Ile Asp Tyr  Asp Asp Thr Ile Ser  Val Glu Met 
    1415                 1420                 1425             


Lys Lys  Glu Asp Phe Asp Ile  Tyr Asp Glu Asp Glu  Asn Gln Ser 
    1430                 1435                 1440             


Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His Tyr Phe  Ile Ala Ala 
    1445                 1450                 1455             


Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser Ser Ser  Pro His Val 
    1460                 1465                 1470             


Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val Pro Gln  Phe Lys Lys 
    1475                 1480                 1485             


Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser Phe Thr  Gln Pro Leu 
    1490                 1495                 1500             


Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly Leu Leu  Gly Pro Tyr 
    1505                 1510                 1515             


Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met Val Thr  Phe Arg Asn 
    1520                 1525                 1530             


Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser Ser Leu  Ile Ser Tyr 
    1535                 1540                 1545             


Glu Glu  Asp Gln Arg Gln Gly  Ala Glu Pro Arg Lys  Asn Phe Val 
    1550                 1555                 1560             


Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp Lys Val  Gln His His 
    1565                 1570                 1575             


Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys Lys Ala  Trp Ala Tyr 
    1580                 1585                 1590             


Phe Ser  Asp Val Asp Leu Glu  Lys Asp Val His Ser  Gly Leu Ile 
    1595                 1600                 1605             


Gly Pro  Leu Leu Val Cys His  Thr Asn Thr Leu Asn  Pro Ala His 
    1610                 1615                 1620             


Gly Arg  Gln Val Thr Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile 
    1625                 1630                 1635             


Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg 
    1640                 1645                 1650             


Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe 
    1655                 1660                 1665             


Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp 
    1670                 1675                 1680             


Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp 
    1685                 1690                 1695             


Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn Ile His  Ser Ile His 
    1700                 1705                 1710             


Phe Ser  Gly His Val Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys 
    1715                 1720                 1725             


Met Ala  Leu Tyr Asn Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu 
    1730                 1735                 1740             


Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile 
    1745                 1750                 1755             


Gly Glu  His Leu His Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr 
    1760                 1765                 1770             


Ser Asn  Lys Cys Gln Thr Pro  Leu Gly Met Ala Ser  Gly His Ile 
    1775                 1780                 1785             


Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala 
    1790                 1795                 1800             


Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp 
    1805                 1810                 1815             


Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala 
    1820                 1825                 1830             


Pro Met  Ile Ile His Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys 
    1835                 1840                 1845             


Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu 
    1850                 1855                 1860             


Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr 
    1865                 1870                 1875             


Leu Met  Val Phe Phe Gly Asn  Val Asp Ser Ser Gly  Ile Lys His 
    1880                 1885                 1890             


Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His 
    1895                 1900                 1905             


Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met 
    1910                 1915                 1920             


Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser 
    1925                 1930                 1935             


Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr 
    1940                 1945                 1950             


Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu 
    1955                 1960                 1965             


Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys 
    1970                 1975                 1980             


Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly 
    1985                 1990                 1995             


Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val 
    2000                 2005                 2010             


Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr 
    2015                 2020                 2025             


Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln 
    2030                 2035                 2040             


Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu 
    2045                 2050                 2055             


Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser Trp Val  His Gln Ile 
    2060                 2065                 2070             


Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    2075                 2080                 2085             


<210>  30
<211>  3710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant pour la protine de fusion de 
       squence SEQ ID NO : 21

<400>  30
atgcagcgcg tgaacatgat catggccgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtccgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat      120

gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat      180

gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactgtggg      240

aacatcacag attttggctc catgccctaa agagaaattg gctttcagat tatttggatt      300

aaaaacaaag actttcttaa gagatgtaaa attttcatga tgttttcttt tttgctaaaa      360

ctaaagaatt attcttttac atttcagtgt ttctggacca cgagaacgcc aacaagatcc      420

tgaaccggcc caagcggtac aactccggca agctggaaga gttcgtgcag ggcaacctgg      480

aacgcgagtg catggaagag aagtgcagct tcgaagaggc cagagaggtg ttcgagaaca      540

ccgagcggac caccgagttc tggaagcagt acgtggacgg cgaccagtgc gagtccaacc      600

cctgcctgaa cggcggctcc tgcaaggacg acatcaactc ctacgagtgc tggtgcccct      660

tcggcttcga gggcaagaac tgcgagctgg acgtgacctg caacatcaag aacggcagat      720

gcgagcagtt ctgcaagaac tccgccgaca acaaggtggt ctgctcctgc accgagggct      780

accggctggc cgagaaccag aagtcctgcg agcccgccgt gcccttccca tgcggcagag      840

tgtccgtgtc ccagacctcc aagctgacca gagccgagac agtgttcccc gacgtggact      900

acgtgaactc caccgaggcc gagacaatcc tggacaacat cacccagtcc acccagagct      960

tcaacgactt caccagagtg gtcggaggcg aggacgccaa gcctggacag ttcccatggc     1020

aagtcgtgct gaacggcaag gtggacgcct tctgcggcgg ctccatcgtg aacgagaagt     1080

ggatcgtgac cgccgctcac tgcgtggaaa caggcgtgaa gatcaccgtg gtggccggcg     1140

agcacaacat cgaggaaacc gagcacaccg agcagaaacg gaacgtgatc agaatcatcc     1200

cccaccacaa ctacaacgcc gccatcaaca agtacaacca cgatatcgcc ctgctggaac     1260

tggacgagcc cctggtgctg aattcctacg tgacccccat ctgtatcgcc gacaaagagt     1320

acaccaacat ctttctgaag ttcggctccg gctacgtgtc cggctggggc agagtgttcc     1380

acaagggcag atccgctctg gtgctgcagt acctgcgggt gcccctggtg gacagagcca     1440

cctgtctgcg gtccaccaag ttcaccatct acaacaacat gttctgcgcc ggcttccacg     1500

agggcggcag agactcttgc cagggcgact ctgggggacc ccatgtgacc gaggtggaag     1560

gcacctcctt tctgaccggc atcatcagct ggggcgagga atgcgccatg aaggggaagt     1620

acggcatcta caccaaggtg tccagatacg tgaactggat caaagaaaag accaagctga     1680

caacgcgtat cgagggacgc atcgtcagca gcggaggaag cggaggaagc ggaggaagcg     1740

gaggaagcgg aggaagcgga ggaagcggaa gcgcggccgc catggaagag aaaccctgtg     1800

gttttcctca tgtggaaaat ggaagaattg cccaatatta ctatactttt aaaagctttt     1860

actttccaat gagcatagac aaaaaattgt catttttctg cttggctggt tataccactg     1920

aaagtggaag acaagaagag caaaccacgt gtaccaccga gggatggtcc cccgagcctc     1980

ggtgcttcaa gaagtgcacc aagcccgacc tgtccaatgg ctacatctcc gacgtgaagc     2040

tgctgtacaa gatccaagaa aacatgcact acggctgcgc ctccggctac aagaccaccg     2100

gcggaaagga cgaagaggtg gtgcagtgcc tgtccgacgg ctggtcctct cagcctacct     2160

gccggaaaga gcacgagact tgcctggccc ccgagctgta caacggcaac tactccacca     2220

cccagaaaac cttcaaagtg aaggacaagg tgcagtacga gtgtgccacc gggtactaca     2280

cagctggcgg caagaaaact gaagaggtgg aatgcctgac ctatggctgg tccctgaccc     2340

ccaagtgtac caagctgaag tgctcctccc tgcggctgat cgagaacggc tacttccacc     2400

ccgtgaagca gacctacgaa gagggcgacg tggtgcagtt cttctgccac gagaactact     2460

acctgtccgg ctccgacctg atccagtgct acaacttcgg ctggtatccc gagtcccccg     2520

tgtgcgaggg cagacggaac aggtgccccc ctccacccct gcccatcaac tccaagatcc     2580

agacccacag caccacctac cggcacggcg agatcgtgca catcgagtgc gagctgaact     2640

tcgagatcca cggctccgcc gagatcagat gcgaggacgg caagtggaca gagcccccca     2700

agtgcatcga gggccaagaa aaggtggcct gcgaggaacc ccccttcatc gaaaacggcg     2760

ctgccaacct gcacagcaag atctactaca acggcgacaa ggtgacctac gcctgcaagt     2820

ccggctatct gctgcacggc agcaacgaga tcacctgtaa ccggggaaag tggaccctgc     2880

cccctgagtg cgtggaaaac aacgagaact gcaagcaccc ccccgtggtg atgaatggcg     2940

ccgtggccga tggcatcctg gcctcttacg ccaccggctc ctccgtggaa taccggtgca     3000

acgagtacta cctgctgcgg ggctccaaga tctcccgctg cgagcagggc aagtggtcta     3060

gcccccctgt gtgcctggaa ccctgcaccg tgaacgtgga ctatatgaac cggaacaata     3120

tcgagatgaa gtggaagtat gagggcaagg tgctgcatgg cgacctgatc gacttcgtgt     3180

gcaagcaggg ctacgacctg tcccccctga cccctctgtc cgagctgtcc gtgcagtgca     3240

accggggcga agtgaagtac cccctgtgca cccggaaaga atccaagggc atgtgcacct     3300

ccccacccct gatcaagcac ggcgtgatca tcagcagcac cgtggacacc tacgagaatg     3360

gcagctctgt ggaatatcgc tgcttcgacc accactttct ggaaggctcc agagaggcct     3420

actgcctgga cggaatgtgg accacccctc ctctgtgtct ggaaccttgt accctgtcct     3480

tcaccgagat ggaaaagaac aacctgctgc tgaagtggga cttcgacaac cggccccaca     3540

tcctgcacgg cgagtacatc gagttcatct gcagaggcga cacctacccc gctgagctgt     3600

acatcaccgg ctccatcctg cggatgcagt gcgacagagg ccagctgaag taccctagat     3660

gcatcccccg gcagagcacc ctgagctacc aagaacccct gcggacctga                3710


<210>  31
<211>  3710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant pour la protine de fusion de 
       squence SEQ ID NO : 23

<400>  31
atgcagcgcg tgaacatgat catggccgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtccgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat      120

gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat      180

gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactgtggg      240

aacatcacag attttggctc catgccctaa agagaaattg gctttcagat tatttggatt      300

aaaaacaaag actttcttaa gagatgtaaa attttcatga tgttttcttt tttgctaaaa      360

ctaaagaatt attcttttac atttcagtgt ttctggacca cgagaacgcc aacaagatcc      420

tgaaccggcc caagcggtac aactccggca agctggaaga gttcgtgcag ggcaacctgg      480

aacgcgagtg catggaagag aagtgcagct tcgaagaggc cagagaggtg ttcgagaaca      540

ccgagcggac caccgagttc tggaagcagt acgtggacgg cgaccagtgc gagtccaacc      600

cctgcctgaa cggcggctcc tgcaaggacg acatcaactc ctacgagtgc tggtgcccct      660

tcggcttcga gggcaagaac tgcgagctgg acgtgacctg caacatcaag aacggcagat      720

gcgagcagtt ctgcaagaac tccgccgaca acaaggtggt ctgctcctgc accgagggct      780

accggctggc cgagaaccag aagtcctgcg agcccgccgt gcccttccca tgcggcagag      840

tgtccgtgtc ccagacctcc aagctgacca gagccgagac agtgttcccc gacgtggact      900

acgtgaactc caccgaggcc gagacaatcc tggacaacat cacccagtcc acccagagct      960

tcaacgactt caccagagtg gtcggaggcg aggacgccaa gcctggacag ttcccatggc     1020

aagtcgtgct gaacggcaag gtggacgcct tctgcggcgg ctccatcgtg aacgagaagt     1080

ggatcgtgac cgccgctcac tgcgtggaaa caggcgtgaa gatcaccgtg gtggccggcg     1140

agcacaacat cgaggaaacc gagcacaccg agcagaaacg gaacgtgatc agaatcatcc     1200

cccaccacaa ctacaacgcc gccatcaaca agtacaacca cgatatcgcc ctgctggaac     1260

tggacgagcc cctggtgctg aattcctacg tgacccccat ctgtatcgcc gacaaagagt     1320

acaccaacat ctttctgaag ttcggctccg gctacgtgtc cggctggggc agagtgttcc     1380

acaagggcag atccgctctg gtgctgcagt acctgcgggt gcccctggtg gacagagcca     1440

cctgtctgcg gtccaccaag ttcaccatct acaacaacat gttctgcgcc ggcttccacg     1500

agggcggcag agactcttgc cagggcgact ctgggggacc ccatgtgacc gaggtggaag     1560

gcacctcctt tctgaccggc atcatcagct ggggcgagga atgcgccatg aaggggaagt     1620

acggcatcta caccaaggtg tccagatacg tgaactggat caaagaaaag accaagctga     1680

caacgcgtgg accacgcagc ttcctcagct ctggcggcag cggaggatct ggcggatcag     1740

gcggatctgg tggaagcggc ggctctggat ctgcggccgc catggaagag aaaccctgtg     1800

gttttcctca tgtggaaaat ggaagaattg cccaatatta ctatactttt aaaagctttt     1860

actttccaat gagcatagac aaaaaattgt catttttctg cttggctggt tataccactg     1920

aaagtggaag acaagaagag caaaccacgt gtaccaccga gggatggtcc cccgagcctc     1980

ggtgcttcaa gaagtgcacc aagcccgacc tgtccaatgg ctacatctcc gacgtgaagc     2040

tgctgtacaa gatccaagaa aacatgcact acggctgcgc ctccggctac aagaccaccg     2100

gcggaaagga cgaagaggtg gtgcagtgcc tgtccgacgg ctggtcctct cagcctacct     2160

gccggaaaga gcacgagact tgcctggccc ccgagctgta caacggcaac tactccacca     2220

cccagaaaac cttcaaagtg aaggacaagg tgcagtacga gtgtgccacc gggtactaca     2280

cagctggcgg caagaaaact gaagaggtgg aatgcctgac ctatggctgg tccctgaccc     2340

ccaagtgtac caagctgaag tgctcctccc tgcggctgat cgagaacggc tacttccacc     2400

ccgtgaagca gacctacgaa gagggcgacg tggtgcagtt cttctgccac gagaactact     2460

acctgtccgg ctccgacctg atccagtgct acaacttcgg ctggtatccc gagtcccccg     2520

tgtgcgaggg cagacggaac aggtgccccc ctccacccct gcccatcaac tccaagatcc     2580

agacccacag caccacctac cggcacggcg agatcgtgca catcgagtgc gagctgaact     2640

tcgagatcca cggctccgcc gagatcagat gcgaggacgg caagtggaca gagcccccca     2700

agtgcatcga gggccaagaa aaggtggcct gcgaggaacc ccccttcatc gaaaacggcg     2760

ctgccaacct gcacagcaag atctactaca acggcgacaa ggtgacctac gcctgcaagt     2820

ccggctatct gctgcacggc agcaacgaga tcacctgtaa ccggggaaag tggaccctgc     2880

cccctgagtg cgtggaaaac aacgagaact gcaagcaccc ccccgtggtg atgaatggcg     2940

ccgtggccga tggcatcctg gcctcttacg ccaccggctc ctccgtggaa taccggtgca     3000

acgagtacta cctgctgcgg ggctccaaga tctcccgctg cgagcagggc aagtggtcta     3060

gcccccctgt gtgcctggaa ccctgcaccg tgaacgtgga ctatatgaac cggaacaata     3120

tcgagatgaa gtggaagtat gagggcaagg tgctgcatgg cgacctgatc gacttcgtgt     3180

gcaagcaggg ctacgacctg tcccccctga cccctctgtc cgagctgtcc gtgcagtgca     3240

accggggcga agtgaagtac cccctgtgca cccggaaaga atccaagggc atgtgcacct     3300

ccccacccct gatcaagcac ggcgtgatca tcagcagcac cgtggacacc tacgagaatg     3360

gcagctctgt ggaatatcgc tgcttcgacc accactttct ggaaggctcc agagaggcct     3420

actgcctgga cggaatgtgg accacccctc ctctgtgtct ggaaccttgt accctgtcct     3480

tcaccgagat ggaaaagaac aacctgctgc tgaagtggga cttcgacaac cggccccaca     3540

tcctgcacgg cgagtacatc gagttcatct gcagaggcga cacctacccc gctgagctgt     3600

acatcaccgg ctccatcctg cggatgcagt gcgacagagg ccagctgaag taccctagat     3660

gcatcccccg gcagagcacc ctgagctacc aagaacccct gcggacctga                3710


<210>  32
<211>  3710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence codant la protine de fusion FIXE410H-LXA-FXIIIB

<400>  32
atgcagcgcg tgaacatgat catggccgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtccgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat      120

gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat      180

gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactgtggg      240

aacatcacag attttggctc catgccctaa agagaaattg gctttcagat tatttggatt      300

aaaaacaaag actttcttaa gagatgtaaa attttcatga tgttttcttt tttgctaaaa      360

ctaaagaatt attcttttac atttcagtgt ttctggacca cgagaacgcc aacaagatcc      420

tgaaccggcc caagcggtac aactccggca agctggaaga gttcgtgcag ggcaacctgg      480

aacgcgagtg catggaagag aagtgcagct tcgaagaggc cagagaggtg ttcgagaaca      540

ccgagcggac caccgagttc tggaagcagt acgtggacgg cgaccagtgc gagtccaacc      600

cctgcctgaa cggcggctcc tgcaaggacg acatcaactc ctacgagtgc tggtgcccct      660

tcggcttcga gggcaagaac tgcgagctgg acgtgacctg caacatcaag aacggcagat      720

gcgagcagtt ctgcaagaac tccgccgaca acaaggtggt ctgctcctgc accgagggct      780

accggctggc cgagaaccag aagtcctgcg agcccgccgt gcccttccca tgcggcagag      840

tgtccgtgtc ccagacctcc aagctgacca gagccgagac agtgttcccc gacgtggact      900

acgtgaactc caccgaggcc gagacaatcc tggacaacat cacccagtcc acccagagct      960

tcaacgactt caccagagtg gtcggaggcg aggacgccaa gcctggacag ttcccatggc     1020

aagtcgtgct gaacggcaag gtggacgcct tctgcggcgg ctccatcgtg aacgagaagt     1080

ggatcgtgac cgccgctcac tgcgtggaaa caggcgtgaa gatcaccgtg gtggccggcg     1140

agcacaacat cgaggaaacc gagcacaccg agcagaaacg gaacgtgatc agaatcatcc     1200

cccaccacaa ctacaacgcc gccatcaaca agtacaacca cgatatcgcc ctgctggaac     1260

tggacgagcc cctggtgctg aattcctacg tgacccccat ctgtatcgcc gacaaagagt     1320

acaccaacat ctttctgaag ttcggctccg gctacgtgtc cggctggggc agagtgttcc     1380

acaagggcag atccgctctg gtgctgcagt acctgcgggt gcccctggtg gacagagcca     1440

cctgtctgcg gtccaccaag ttcaccatct acaacaacat gttctgcgcc ggcttccacg     1500

agggcggcag agactcttgc cagggcgact ctgggggacc ccatgtgacc gaggtggaag     1560

gcacctcctt tctgaccggc atcatcagct ggggcgagga atgcgccatg aaggggaagt     1620

acggcatcta caccaaggtg tccagatacg tgaactggat caaacataag accaagctga     1680

caacgcgtat cgagggacgc atcgtcagca gcggaggaag cggaggaagc ggaggaagcg     1740

gaggaagcgg aggaagcgga ggaagcggaa gcgcggccgc catggaagag aaaccctgtg     1800

gttttcctca tgtggaaaat ggaagaattg cccaatatta ctatactttt aaaagctttt     1860

actttccaat gagcatagac aaaaaattgt catttttctg cttggctggt tataccactg     1920

aaagtggaag acaagaagag caaaccacgt gtaccaccga gggatggtcc cccgagcctc     1980

ggtgcttcaa gaagtgcacc aagcccgacc tgtccaatgg ctacatctcc gacgtgaagc     2040

tgctgtacaa gatccaagaa aacatgcact acggctgcgc ctccggctac aagaccaccg     2100

gcggaaagga cgaagaggtg gtgcagtgcc tgtccgacgg ctggtcctct cagcctacct     2160

gccggaaaga gcacgagact tgcctggccc ccgagctgta caacggcaac tactccacca     2220

cccagaaaac cttcaaagtg aaggacaagg tgcagtacga gtgtgccacc gggtactaca     2280

cagctggcgg caagaaaact gaagaggtgg aatgcctgac ctatggctgg tccctgaccc     2340

ccaagtgtac caagctgaag tgctcctccc tgcggctgat cgagaacggc tacttccacc     2400

ccgtgaagca gacctacgaa gagggcgacg tggtgcagtt cttctgccac gagaactact     2460

acctgtccgg ctccgacctg atccagtgct acaacttcgg ctggtatccc gagtcccccg     2520

tgtgcgaggg cagacggaac aggtgccccc ctccacccct gcccatcaac tccaagatcc     2580

agacccacag caccacctac cggcacggcg agatcgtgca catcgagtgc gagctgaact     2640

tcgagatcca cggctccgcc gagatcagat gcgaggacgg caagtggaca gagcccccca     2700

agtgcatcga gggccaagaa aaggtggcct gcgaggaacc ccccttcatc gaaaacggcg     2760

ctgccaacct gcacagcaag atctactaca acggcgacaa ggtgacctac gcctgcaagt     2820

ccggctatct gctgcacggc agcaacgaga tcacctgtaa ccggggaaag tggaccctgc     2880

cccctgagtg cgtggaaaac aacgagaact gcaagcaccc ccccgtggtg atgaatggcg     2940

ccgtggccga tggcatcctg gcctcttacg ccaccggctc ctccgtggaa taccggtgca     3000

acgagtacta cctgctgcgg ggctccaaga tctcccgctg cgagcagggc aagtggtcta     3060

gcccccctgt gtgcctggaa ccctgcaccg tgaacgtgga ctatatgaac cggaacaata     3120

tcgagatgaa gtggaagtat gagggcaagg tgctgcatgg cgacctgatc gacttcgtgt     3180

gcaagcaggg ctacgacctg tcccccctga cccctctgtc cgagctgtcc gtgcagtgca     3240

accggggcga agtgaagtac cccctgtgca cccggaaaga atccaagggc atgtgcacct     3300

ccccacccct gatcaagcac ggcgtgatca tcagcagcac cgtggacacc tacgagaatg     3360

gcagctctgt ggaatatcgc tgcttcgacc accactttct ggaaggctcc agagaggcct     3420

actgcctgga cggaatgtgg accacccctc ctctgtgtct ggaaccttgt accctgtcct     3480

tcaccgagat ggaaaagaac aacctgctgc tgaagtggga cttcgacaac cggccccaca     3540

tcctgcacgg cgagtacatc gagttcatct gcagaggcga cacctacccc gctgagctgt     3600

acatcaccgg ctccatcctg cggatgcagt gcgacagagg ccagctgaag taccctagat     3660

gcatcccccg gcagagcacc ctgagctacc aagaacccct gcggacctga                3710


<210>  33
<211>  3710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence codant la protine de fusion FIXE410H-LIIA-FXIIIB

<400>  33
atgcagcgcg tgaacatgat catggccgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtccgccga gtgtacaggt ttgtttcctt ttttaaaata cattgagtat      120

gcttgccttt tagatataga aatatctgat gctgtcttct tcactaaatt ttgattacat      180

gatttgacag caatattgaa gagtctaaca gccagcacgc aggttggtaa gtactgtggg      240

aacatcacag attttggctc catgccctaa agagaaattg gctttcagat tatttggatt      300

aaaaacaaag actttcttaa gagatgtaaa attttcatga tgttttcttt tttgctaaaa      360

ctaaagaatt attcttttac atttcagtgt ttctggacca cgagaacgcc aacaagatcc      420

tgaaccggcc caagcggtac aactccggca agctggaaga gttcgtgcag ggcaacctgg      480

aacgcgagtg catggaagag aagtgcagct tcgaagaggc cagagaggtg ttcgagaaca      540

ccgagcggac caccgagttc tggaagcagt acgtggacgg cgaccagtgc gagtccaacc      600

cctgcctgaa cggcggctcc tgcaaggacg acatcaactc ctacgagtgc tggtgcccct      660

tcggcttcga gggcaagaac tgcgagctgg acgtgacctg caacatcaag aacggcagat      720

gcgagcagtt ctgcaagaac tccgccgaca acaaggtggt ctgctcctgc accgagggct      780

accggctggc cgagaaccag aagtcctgcg agcccgccgt gcccttccca tgcggcagag      840

tgtccgtgtc ccagacctcc aagctgacca gagccgagac agtgttcccc gacgtggact      900

acgtgaactc caccgaggcc gagacaatcc tggacaacat cacccagtcc acccagagct      960

tcaacgactt caccagagtg gtcggaggcg aggacgccaa gcctggacag ttcccatggc     1020

aagtcgtgct gaacggcaag gtggacgcct tctgcggcgg ctccatcgtg aacgagaagt     1080

ggatcgtgac cgccgctcac tgcgtggaaa caggcgtgaa gatcaccgtg gtggccggcg     1140

agcacaacat cgaggaaacc gagcacaccg agcagaaacg gaacgtgatc agaatcatcc     1200

cccaccacaa ctacaacgcc gccatcaaca agtacaacca cgatatcgcc ctgctggaac     1260

tggacgagcc cctggtgctg aattcctacg tgacccccat ctgtatcgcc gacaaagagt     1320

acaccaacat ctttctgaag ttcggctccg gctacgtgtc cggctggggc agagtgttcc     1380

acaagggcag atccgctctg gtgctgcagt acctgcgggt gcccctggtg gacagagcca     1440

cctgtctgcg gtccaccaag ttcaccatct acaacaacat gttctgcgcc ggcttccacg     1500

agggcggcag agactcttgc cagggcgact ctgggggacc ccatgtgacc gaggtggaag     1560

gcacctcctt tctgaccggc atcatcagct ggggcgagga atgcgccatg aaggggaagt     1620

acggcatcta caccaaggtg tccagatacg tgaactggat caaacataag accaagctga     1680

caacgcgtgg accacgcagc ttcctcagct ctggcggcag cggaggatct ggcggatcag     1740

gcggatctgg tggaagcggc ggctctggat ctgcggccgc catggaagag aaaccctgtg     1800

gttttcctca tgtggaaaat ggaagaattg cccaatatta ctatactttt aaaagctttt     1860

actttccaat gagcatagac aaaaaattgt catttttctg cttggctggt tataccactg     1920

aaagtggaag acaagaagag caaaccacgt gtaccaccga gggatggtcc cccgagcctc     1980

ggtgcttcaa gaagtgcacc aagcccgacc tgtccaatgg ctacatctcc gacgtgaagc     2040

tgctgtacaa gatccaagaa aacatgcact acggctgcgc ctccggctac aagaccaccg     2100

gcggaaagga cgaagaggtg gtgcagtgcc tgtccgacgg ctggtcctct cagcctacct     2160

gccggaaaga gcacgagact tgcctggccc ccgagctgta caacggcaac tactccacca     2220

cccagaaaac cttcaaagtg aaggacaagg tgcagtacga gtgtgccacc gggtactaca     2280

cagctggcgg caagaaaact gaagaggtgg aatgcctgac ctatggctgg tccctgaccc     2340

ccaagtgtac caagctgaag tgctcctccc tgcggctgat cgagaacggc tacttccacc     2400

ccgtgaagca gacctacgaa gagggcgacg tggtgcagtt cttctgccac gagaactact     2460

acctgtccgg ctccgacctg atccagtgct acaacttcgg ctggtatccc gagtcccccg     2520

tgtgcgaggg cagacggaac aggtgccccc ctccacccct gcccatcaac tccaagatcc     2580

agacccacag caccacctac cggcacggcg agatcgtgca catcgagtgc gagctgaact     2640

tcgagatcca cggctccgcc gagatcagat gcgaggacgg caagtggaca gagcccccca     2700

agtgcatcga gggccaagaa aaggtggcct gcgaggaacc ccccttcatc gaaaacggcg     2760

ctgccaacct gcacagcaag atctactaca acggcgacaa ggtgacctac gcctgcaagt     2820

ccggctatct gctgcacggc agcaacgaga tcacctgtaa ccggggaaag tggaccctgc     2880

cccctgagtg cgtggaaaac aacgagaact gcaagcaccc ccccgtggtg atgaatggcg     2940

ccgtggccga tggcatcctg gcctcttacg ccaccggctc ctccgtggaa taccggtgca     3000

acgagtacta cctgctgcgg ggctccaaga tctcccgctg cgagcagggc aagtggtcta     3060

gcccccctgt gtgcctggaa ccctgcaccg tgaacgtgga ctatatgaac cggaacaata     3120

tcgagatgaa gtggaagtat gagggcaagg tgctgcatgg cgacctgatc gacttcgtgt     3180

gcaagcaggg ctacgacctg tcccccctga cccctctgtc cgagctgtcc gtgcagtgca     3240

accggggcga agtgaagtac cccctgtgca cccggaaaga atccaagggc atgtgcacct     3300

ccccacccct gatcaagcac ggcgtgatca tcagcagcac cgtggacacc tacgagaatg     3360

gcagctctgt ggaatatcgc tgcttcgacc accactttct ggaaggctcc agagaggcct     3420

actgcctgga cggaatgtgg accacccctc ctctgtgtct ggaaccttgt accctgtcct     3480

tcaccgagat ggaaaagaac aacctgctgc tgaagtggga cttcgacaac cggccccaca     3540

tcctgcacgg cgagtacatc gagttcatct gcagaggcga cacctacccc gctgagctgt     3600

acatcaccgg ctccatcctg cggatgcagt gcgacagagg ccagctgaag taccctagat     3660

gcatcccccg gcagagcacc ctgagctacc aagaacccct gcggacctga                3710


<210>  34
<211>  6993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence codant la protine de fusion FVIII-LXA-FXIIIB

<400>  34
atggaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aaggtttgtt tatgcatcct tttttaaaat acattgagta      180

tgcttgcctt ttagatatag aaatatctga tgctgtcttc ttcactaaat tttgattaca      240

tgatttgaca gcaatattga agagtctaac agccagcacg caggttggta agtactgtgg      300

gaacatcaca gattttggct ccatgcccta aagagaaatt ggctttcaga ttatttggat      360

taaaaacaaa gactttctta agagatgtaa aattttcatg atgttttctt ttttgctaaa      420

actaaagaat taacgcgtat tcttttacat ttcagatttc ctcctagagt gccaaaatct      480

tttccattca acacctcagt cgtgtacaaa aagactctgt ttgtagaatt cacggatcac      540

cttttcaaca tcgctaagcc aaggccaccc tggatgggtc tgctaggtcc taccatccag      600

gctgaggttt atgatacagt ggtcattaca cttaagaaca tggcttccca tcctgtcagt      660

cttcatgctg ttggtgtatc ctactggaaa gcttctgagg gagctgaata tgatgatcag      720

accagtcaaa gggagaaaga agatgataaa gtcttccctg gtggaagcca tacatatgtc      780

tggcaggtcc tgaaagagaa tggtccaatg gcctctgacc cactgtgcct tacctactca      840

tatctttctc atgtggacct ggtaaaagac ttgaattcag gcctcattgg agccctacta      900

gtatgtagag aagggagtct ggccaaggaa aagacacaga ccttgcacaa atttatacta      960

ctttttgctg tatttgatga agggaaaagt tggcactcag aaacaaagaa ctccttgatg     1020

caggataggg atgctgcatc tgctcgggcc tggcctaaaa tgcacacagt caatggttat     1080

gtaaacaggt ctctgccagg tctgattgga tgccacagga aatcagtcta ttggcatgtg     1140

attggaatgg gcaccactcc tgaagtgcac tcaatattcc tcgaaggtca cacatttctt     1200

gtgaggaacc atcgccaggc gtccttggaa atctcgccaa taactttcct tactgctcaa     1260

acactcttga tggaccttgg acagtttcta ctgttttgtc atatctcttc ccaccaacat     1320

gatggcatgg aagcttatgt caaagtagac agctgtccag aggaacccca actacgaatg     1380

aaaaataatg aagaagcgga agactatgat gatgatctta ctgattctga aatggatgtg     1440

gtcaggtttg atgatgacaa ctctccttcc tttatccaaa ttcgctcagt tgccaagaag     1500

catcctaaaa cttgggtaca ttacattgct gctgaagagg aggactggga ctatgctccc     1560

ttagtcctcg cccccgatga cagaagttat aaaagtcaat atttgaacaa tggccctcag     1620

cggattggta ggaagtacaa aaaagtccga tttatggcat acacagatga aacctttaag     1680

actcgtgaag ctattcagca tgaatcagga atcttgggac ctttacttta tggggaagtt     1740

ggagacacac tgttgattat atttaagaat caagcaagca gaccatataa catctaccct     1800

cacggaatca ctgatgtccg tcctttgtat tcaaggagat taccaaaagg tgtaaaacat     1860

ttgaaggatt ttccaattct gccaggagaa atattcaaat ataaatggac agtgactgta     1920

gaagatgggc caactaaatc agatcctcgg tgcctgaccc gctattactc tagtttcgtt     1980

aatatggaga gagatctagc ttcaggactc attggccctc tcctcatctg ctacaaagaa     2040

tctgtagatc aaagaggaaa ccagataatg tcagacaaga ggaatgtcat cctgttttct     2100

gtatttgatg agaaccgaag ctggtacctc acagagaata tacaacgctt tctccccaat     2160

ccagctggag tgcagcttga ggatccagag ttccaagcct ccaacatcat gcacagcatc     2220

aatggctatg tttttgatag tttgcagttg tcagtttgtt tgcatgaggt ggcatactgg     2280

tacattctaa gcattggagc acagactgac ttcctttctg tcttcttctc tggatatacc     2340

ttcaaacaca aaatggtcta tgaagacaca ctcaccctat tcccattctc aggagaaact     2400

gtcttcatgt cgatggaaaa cccaggtttg tttatgcatc cttttttaaa atacattgag     2460

tatgcttgcc ttttagatat agaaatatct gatgctgtct tcttcactaa attttgatta     2520

catgatttga cagcaatatt gaagagtcta acagccagca cgcaggttgg taagtactgt     2580

gggaacatca cagattttgg ctccatgccc taaagagaaa ttggctttca gattatttgg     2640

attaaaaaca aagactttct taagagatgt aaaattttca tgatgttttc ttttttgcta     2700

aaactaaaga attaacgcgt attcttttac atttcaggtc tatggattct ggggtgccac     2760

aactcagact ttcggaacag aggcatgacc gccttactga aggtttctag ttgtgacaag     2820

aacactggtg attattacga ggacagttat gaagatattt cagcatactt gctgagtaaa     2880

aacaatgcca ttgaaccaag aagacgtcga cgagaaataa ctcgtactac tcttcagtca     2940

gatcaagagg aaattgacta tgatgatacc atatcagttg aaatgaagaa ggaagatttt     3000

gacatttatg atgaggatga aaatcagagc ccccgcagct ttcaaaagaa aacacgacac     3060

tattttattg ctgcagtgga gaggctctgg gattatggga tgagtagctc cccacatgtt     3120

ctaagaaaca gggctcagag tggcagtgtc cctcagttca agaaagttgt tttccaggaa     3180

tttactgatg gctcctttac tcagccctta taccgtggag aactaaatga acatttggga     3240

ctcctggggc catatataag agcagaagtt gaagataata tcatggtaac tttcagaaat     3300

caggcctctc gtccctattc cttctattct agccttattt cttatgagga agatcagagg     3360

caaggagcag aacctagaaa aaactttgtc aagcctaatg aaaccaaaac ttacttttgg     3420

aaagtgcaac atcatatggc acccactaaa gatgagtttg actgcaaagc ctgggcttat     3480

ttctctgatg ttgacctgga aaaagatgtg cactcaggcc tgattggacc ccttctggtc     3540

tgccacacta acacactgaa ccctgctcat gggagacaag tgacagtaca ggaatttgct     3600

ctgtttttca ccatctttga tgagaccaaa agctggtact tcactgaaaa tatggaaaga     3660

aactgcaggg ctccctgcaa tatccagatg gaagatccca cttttaaaga gaattatcgc     3720

ttccatgcaa tcaatggcta cataatggat acactacctg gcttagtaat ggctcaggat     3780

caaaggattc gatggtatct gctcagcatg ggcagcaatg aaaacatcca ttctattcat     3840

ttcagtggac atgtgttcac tgtacgaaaa aaagaggagt ataaaatggc actgtacaat     3900

ctctatccag gtgtttttga gacagtggaa atgttaccat ccaaagctgg aatttggcgg     3960

gtggaatgcc ttattggcga gcatctacat gctgggatga gcacactttt tctggtgtac     4020

agcaataagt gtcagactcc cctgggaatg gcttctggac acattagaga ttttcagatt     4080

acagcttcag gacaatatgg acagtgggcc ccaaagctgg ccagacttca ttattccgga     4140

tcaatcaatg cctggagcac caaggagccc ttttcttgga tcaaggtgga tctgttggca     4200

ccaatgatta ttcacggcat caagacccag ggtgcccgtc agaagttctc cagcctctac     4260

atctctcagt ttatcatcat gtatagtctt gatgggaaga agtggcagac ttatcgagga     4320

aattccactg gaaccttaat ggtcttcttt ggcaatgtgg attcatctgg gataaaacac     4380

aatattttta accctccaat tattgctcga tacatccgtt tgcacccaac tcattatagc     4440

attcgcagca ctcttcgcat ggagttgatg ggctgtgatt taaatagttg cagcatgcca     4500

ttgggaatgg agagtaaagc aatatcagat gcacagatta ctgcttcatc ctactttacc     4560

aatatgtttg ccacctggtc tccttcaaaa gctcgacttc acctccaagg gaggagtaat     4620

gcctggagac ctcaggtgaa taatccaaaa gagtggctgc aagtggactt ccagaagaca     4680

atgaaagtca caggagtaac tactcaggga gtaaaatctc tgcttaccag catgtatgtg     4740

aaggagttcc tcatctccag cagtcaagat ggccatcagt ggactctctt ttttcagaat     4800

ggcaaagtaa aggtttttca gggaaatcaa gactccttca cacctgtggt gaactctcta     4860

gacccaccgt tactgactcg ctaccttcga attcaccccc agagttgggt gcaccagatt     4920

gccctgagga tggaggttct gggctgcgag gcacaggacc tctacacgcg tatcgaggga     4980

cgcatcgtca gcagcggagg aagcggagga agcggaggaa gcggaggaag cggaggaagc     5040

ggaggaagcg gaagcgcggc cgccatggaa gagaaaccct gtggttttcc tcatgtggaa     5100

aatggaagaa ttgcccaata ttactatact tttaaaagct tttactttcc aatgagcata     5160

gacaaaaaat tgtcattttt ctgcttggct ggttatacca ctgaaagtgg aagacaagaa     5220

gagcaaacca cgtgtaccac cgagggatgg tcccccgagc ctcggtgctt caagaagtgc     5280

accaagcccg acctgtccaa tggctacatc tccgacgtga agctgctgta caagatccaa     5340

gaaaacatgc actacggctg cgcctccggc tacaagacca ccggcggaaa ggacgaagag     5400

gtggtgcagt gcctgtccga cggctggtcc tctcagccta cctgccggaa agagcacgag     5460

acttgcctgg cccccgagct gtacaacggc aactactcca ccacccagaa aaccttcaaa     5520

gtgaaggaca aggtgcagta cgagtgtgcc accgggtact acacagctgg cggcaagaaa     5580

actgaagagg tggaatgcct gacctatggc tggtccctga cccccaagtg taccaagctg     5640

aagtgctcct ccctgcggct gatcgagaac ggctacttcc accccgtgaa gcagacctac     5700

gaagagggcg acgtggtgca gttcttctgc cacgagaact actacctgtc cggctccgac     5760

ctgatccagt gctacaactt cggctggtat cccgagtccc ccgtgtgcga gggcagacgg     5820

aacaggtgcc cccctccacc cctgcccatc aactccaaga tccagaccca cagcaccacc     5880

taccggcacg gcgagatcgt gcacatcgag tgcgagctga acttcgagat ccacggctcc     5940

gccgagatca gatgcgagga cggcaagtgg acagagcccc ccaagtgcat cgagggccaa     6000

gaaaaggtgg cctgcgagga accccccttc atcgaaaacg gcgctgccaa cctgcacagc     6060

aagatctact acaacggcga caaggtgacc tacgcctgca agtccggcta tctgctgcac     6120

ggcagcaacg agatcacctg taaccgggga aagtggaccc tgccccctga gtgcgtggaa     6180

aacaacgaga actgcaagca cccccccgtg gtgatgaatg gcgccgtggc cgatggcatc     6240

ctggcctctt acgccaccgg ctcctccgtg gaataccggt gcaacgagta ctacctgctg     6300

cggggctcca agatctcccg ctgcgagcag ggcaagtggt ctagcccccc tgtgtgcctg     6360

gaaccctgca ccgtgaacgt ggactatatg aaccggaaca atatcgagat gaagtggaag     6420

tatgagggca aggtgctgca tggcgacctg atcgacttcg tgtgcaagca gggctacgac     6480

ctgtcccccc tgacccctct gtccgagctg tccgtgcagt gcaaccgggg cgaagtgaag     6540

taccccctgt gcacccggaa agaatccaag ggcatgtgca cctccccacc cctgatcaag     6600

cacggcgtga tcatcagcag caccgtggac acctacgaga atggcagctc tgtggaatat     6660

cgctgcttcg accaccactt tctggaaggc tccagagagg cctactgcct ggacggaatg     6720

tggaccaccc ctcctctgtg tctggaacct tgtaccctgt ccttcaccga gatggaaaag     6780

aacaacctgc tgctgaagtg ggacttcgac aaccggcccc acatcctgca cggcgagtac     6840

atcgagttca tctgcagagg cgacacctac cccgctgagc tgtacatcac cggctccatc     6900

ctgcggatgc agtgcgacag aggccagctg aagtacccta gatgcatccc ccggcagagc     6960

accctgagct accaagaacc cctgcggacc tga                                  6993


<210>  35
<211>  6993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence codant la protine de fusion FVIII-LIIA-FXIIIB

<400>  35
atggaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aaggtttgtt tatgcatcct tttttaaaat acattgagta      180

tgcttgcctt ttagatatag aaatatctga tgctgtcttc ttcactaaat tttgattaca      240

tgatttgaca gcaatattga agagtctaac agccagcacg caggttggta agtactgtgg      300

gaacatcaca gattttggct ccatgcccta aagagaaatt ggctttcaga ttatttggat      360

taaaaacaaa gactttctta agagatgtaa aattttcatg atgttttctt ttttgctaaa      420

actaaagaat taacgcgtat tcttttacat ttcagatttc ctcctagagt gccaaaatct      480

tttccattca acacctcagt cgtgtacaaa aagactctgt ttgtagaatt cacggatcac      540

cttttcaaca tcgctaagcc aaggccaccc tggatgggtc tgctaggtcc taccatccag      600

gctgaggttt atgatacagt ggtcattaca cttaagaaca tggcttccca tcctgtcagt      660

cttcatgctg ttggtgtatc ctactggaaa gcttctgagg gagctgaata tgatgatcag      720

accagtcaaa gggagaaaga agatgataaa gtcttccctg gtggaagcca tacatatgtc      780

tggcaggtcc tgaaagagaa tggtccaatg gcctctgacc cactgtgcct tacctactca      840

tatctttctc atgtggacct ggtaaaagac ttgaattcag gcctcattgg agccctacta      900

gtatgtagag aagggagtct ggccaaggaa aagacacaga ccttgcacaa atttatacta      960

ctttttgctg tatttgatga agggaaaagt tggcactcag aaacaaagaa ctccttgatg     1020

caggataggg atgctgcatc tgctcgggcc tggcctaaaa tgcacacagt caatggttat     1080

gtaaacaggt ctctgccagg tctgattgga tgccacagga aatcagtcta ttggcatgtg     1140

attggaatgg gcaccactcc tgaagtgcac tcaatattcc tcgaaggtca cacatttctt     1200

gtgaggaacc atcgccaggc gtccttggaa atctcgccaa taactttcct tactgctcaa     1260

acactcttga tggaccttgg acagtttcta ctgttttgtc atatctcttc ccaccaacat     1320

gatggcatgg aagcttatgt caaagtagac agctgtccag aggaacccca actacgaatg     1380

aaaaataatg aagaagcgga agactatgat gatgatctta ctgattctga aatggatgtg     1440

gtcaggtttg atgatgacaa ctctccttcc tttatccaaa ttcgctcagt tgccaagaag     1500

catcctaaaa cttgggtaca ttacattgct gctgaagagg aggactggga ctatgctccc     1560

ttagtcctcg cccccgatga cagaagttat aaaagtcaat atttgaacaa tggccctcag     1620

cggattggta ggaagtacaa aaaagtccga tttatggcat acacagatga aacctttaag     1680

actcgtgaag ctattcagca tgaatcagga atcttgggac ctttacttta tggggaagtt     1740

ggagacacac tgttgattat atttaagaat caagcaagca gaccatataa catctaccct     1800

cacggaatca ctgatgtccg tcctttgtat tcaaggagat taccaaaagg tgtaaaacat     1860

ttgaaggatt ttccaattct gccaggagaa atattcaaat ataaatggac agtgactgta     1920

gaagatgggc caactaaatc agatcctcgg tgcctgaccc gctattactc tagtttcgtt     1980

aatatggaga gagatctagc ttcaggactc attggccctc tcctcatctg ctacaaagaa     2040

tctgtagatc aaagaggaaa ccagataatg tcagacaaga ggaatgtcat cctgttttct     2100

gtatttgatg agaaccgaag ctggtacctc acagagaata tacaacgctt tctccccaat     2160

ccagctggag tgcagcttga ggatccagag ttccaagcct ccaacatcat gcacagcatc     2220

aatggctatg tttttgatag tttgcagttg tcagtttgtt tgcatgaggt ggcatactgg     2280

tacattctaa gcattggagc acagactgac ttcctttctg tcttcttctc tggatatacc     2340

ttcaaacaca aaatggtcta tgaagacaca ctcaccctat tcccattctc aggagaaact     2400

gtcttcatgt cgatggaaaa cccaggtttg tttatgcatc cttttttaaa atacattgag     2460

tatgcttgcc ttttagatat agaaatatct gatgctgtct tcttcactaa attttgatta     2520

catgatttga cagcaatatt gaagagtcta acagccagca cgcaggttgg taagtactgt     2580

gggaacatca cagattttgg ctccatgccc taaagagaaa ttggctttca gattatttgg     2640

attaaaaaca aagactttct taagagatgt aaaattttca tgatgttttc ttttttgcta     2700

aaactaaaga attaacgcgt attcttttac atttcaggtc tatggattct ggggtgccac     2760

aactcagact ttcggaacag aggcatgacc gccttactga aggtttctag ttgtgacaag     2820

aacactggtg attattacga ggacagttat gaagatattt cagcatactt gctgagtaaa     2880

aacaatgcca ttgaaccaag aagacgtcga cgagaaataa ctcgtactac tcttcagtca     2940

gatcaagagg aaattgacta tgatgatacc atatcagttg aaatgaagaa ggaagatttt     3000

gacatttatg atgaggatga aaatcagagc ccccgcagct ttcaaaagaa aacacgacac     3060

tattttattg ctgcagtgga gaggctctgg gattatggga tgagtagctc cccacatgtt     3120

ctaagaaaca gggctcagag tggcagtgtc cctcagttca agaaagttgt tttccaggaa     3180

tttactgatg gctcctttac tcagccctta taccgtggag aactaaatga acatttggga     3240

ctcctggggc catatataag agcagaagtt gaagataata tcatggtaac tttcagaaat     3300

caggcctctc gtccctattc cttctattct agccttattt cttatgagga agatcagagg     3360

caaggagcag aacctagaaa aaactttgtc aagcctaatg aaaccaaaac ttacttttgg     3420

aaagtgcaac atcatatggc acccactaaa gatgagtttg actgcaaagc ctgggcttat     3480

ttctctgatg ttgacctgga aaaagatgtg cactcaggcc tgattggacc ccttctggtc     3540

tgccacacta acacactgaa ccctgctcat gggagacaag tgacagtaca ggaatttgct     3600

ctgtttttca ccatctttga tgagaccaaa agctggtact tcactgaaaa tatggaaaga     3660

aactgcaggg ctccctgcaa tatccagatg gaagatccca cttttaaaga gaattatcgc     3720

ttccatgcaa tcaatggcta cataatggat acactacctg gcttagtaat ggctcaggat     3780

caaaggattc gatggtatct gctcagcatg ggcagcaatg aaaacatcca ttctattcat     3840

ttcagtggac atgtgttcac tgtacgaaaa aaagaggagt ataaaatggc actgtacaat     3900

ctctatccag gtgtttttga gacagtggaa atgttaccat ccaaagctgg aatttggcgg     3960

gtggaatgcc ttattggcga gcatctacat gctgggatga gcacactttt tctggtgtac     4020

agcaataagt gtcagactcc cctgggaatg gcttctggac acattagaga ttttcagatt     4080

acagcttcag gacaatatgg acagtgggcc ccaaagctgg ccagacttca ttattccgga     4140

tcaatcaatg cctggagcac caaggagccc ttttcttgga tcaaggtgga tctgttggca     4200

ccaatgatta ttcacggcat caagacccag ggtgcccgtc agaagttctc cagcctctac     4260

atctctcagt ttatcatcat gtatagtctt gatgggaaga agtggcagac ttatcgagga     4320

aattccactg gaaccttaat ggtcttcttt ggcaatgtgg attcatctgg gataaaacac     4380

aatattttta accctccaat tattgctcga tacatccgtt tgcacccaac tcattatagc     4440

attcgcagca ctcttcgcat ggagttgatg ggctgtgatt taaatagttg cagcatgcca     4500

ttgggaatgg agagtaaagc aatatcagat gcacagatta ctgcttcatc ctactttacc     4560

aatatgtttg ccacctggtc tccttcaaaa gctcgacttc acctccaagg gaggagtaat     4620

gcctggagac ctcaggtgaa taatccaaaa gagtggctgc aagtggactt ccagaagaca     4680

atgaaagtca caggagtaac tactcaggga gtaaaatctc tgcttaccag catgtatgtg     4740

aaggagttcc tcatctccag cagtcaagat ggccatcagt ggactctctt ttttcagaat     4800

ggcaaagtaa aggtttttca gggaaatcaa gactccttca cacctgtggt gaactctcta     4860

gacccaccgt tactgactcg ctaccttcga attcaccccc agagttgggt gcaccagatt     4920

gccctgagga tggaggttct gggctgcgag gcacaggacc tctacacgcg tggaccacgc     4980

agcttcctca gctctggcgg cagcggagga tctggcggat caggcggatc tggtggaagc     5040

ggcggctctg gatctgcggc cgccatggaa gagaaaccct gtggttttcc tcatgtggaa     5100

aatggaagaa ttgcccaata ttactatact tttaaaagct tttactttcc aatgagcata     5160

gacaaaaaat tgtcattttt ctgcttggct ggttatacca ctgaaagtgg aagacaagaa     5220

gagcaaacca cgtgtaccac cgagggatgg tcccccgagc ctcggtgctt caagaagtgc     5280

accaagcccg acctgtccaa tggctacatc tccgacgtga agctgctgta caagatccaa     5340

gaaaacatgc actacggctg cgcctccggc tacaagacca ccggcggaaa ggacgaagag     5400

gtggtgcagt gcctgtccga cggctggtcc tctcagccta cctgccggaa agagcacgag     5460

acttgcctgg cccccgagct gtacaacggc aactactcca ccacccagaa aaccttcaaa     5520

gtgaaggaca aggtgcagta cgagtgtgcc accgggtact acacagctgg cggcaagaaa     5580

actgaagagg tggaatgcct gacctatggc tggtccctga cccccaagtg taccaagctg     5640

aagtgctcct ccctgcggct gatcgagaac ggctacttcc accccgtgaa gcagacctac     5700

gaagagggcg acgtggtgca gttcttctgc cacgagaact actacctgtc cggctccgac     5760

ctgatccagt gctacaactt cggctggtat cccgagtccc ccgtgtgcga gggcagacgg     5820

aacaggtgcc cccctccacc cctgcccatc aactccaaga tccagaccca cagcaccacc     5880

taccggcacg gcgagatcgt gcacatcgag tgcgagctga acttcgagat ccacggctcc     5940

gccgagatca gatgcgagga cggcaagtgg acagagcccc ccaagtgcat cgagggccaa     6000

gaaaaggtgg cctgcgagga accccccttc atcgaaaacg gcgctgccaa cctgcacagc     6060

aagatctact acaacggcga caaggtgacc tacgcctgca agtccggcta tctgctgcac     6120

ggcagcaacg agatcacctg taaccgggga aagtggaccc tgccccctga gtgcgtggaa     6180

aacaacgaga actgcaagca cccccccgtg gtgatgaatg gcgccgtggc cgatggcatc     6240

ctggcctctt acgccaccgg ctcctccgtg gaataccggt gcaacgagta ctacctgctg     6300

cggggctcca agatctcccg ctgcgagcag ggcaagtggt ctagcccccc tgtgtgcctg     6360

gaaccctgca ccgtgaacgt ggactatatg aaccggaaca atatcgagat gaagtggaag     6420

tatgagggca aggtgctgca tggcgacctg atcgacttcg tgtgcaagca gggctacgac     6480

ctgtcccccc tgacccctct gtccgagctg tccgtgcagt gcaaccgggg cgaagtgaag     6540

taccccctgt gcacccggaa agaatccaag ggcatgtgca cctccccacc cctgatcaag     6600

cacggcgtga tcatcagcag caccgtggac acctacgaga atggcagctc tgtggaatat     6660

cgctgcttcg accaccactt tctggaaggc tccagagagg cctactgcct ggacggaatg     6720

tggaccaccc ctcctctgtg tctggaacct tgtaccctgt ccttcaccga gatggaaaag     6780

aacaacctgc tgctgaagtg ggacttcgac aaccggcccc acatcctgca cggcgagtac     6840

atcgagttca tctgcagagg cgacacctac cccgctgagc tgtacatcac cggctccatc     6900

ctgcggatgc agtgcgacag aggccagctg aagtacccta gatgcatccc ccggcagagc     6960

accctgagct accaagaacc cctgcggacc tga                                  6993


<210>  36
<211>  6891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence nuclotidique codant pour la protine de fusion de 
       squence SEQ ID NO : 29

<400>  36
atggaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aaggtttgtt tatgcatcct tttttaaaat acattgagta      180

tgcttgcctt ttagatatag aaatatctga tgctgtcttc ttcactaaat tttgattaca      240

tgatttgaca gcaatattga agagtctaac agccagcacg caggttggta agtactgtgg      300

gaacatcaca gattttggct ccatgcccta aagagaaatt ggctttcaga ttatttggat      360

taaaaacaaa gactttctta agagatgtaa aattttcatg atgttttctt ttttgctaaa      420

actaaagaat taacgcgtat tcttttacat ttcagatttc ctcctagagt gccaaaatct      480

tttccattca acacctcagt cgtgtacaaa aagactctgt ttgtagaatt cacggatcac      540

cttttcaaca tcgctaagcc aaggccaccc tggatgggtc tgctaggtcc taccatccag      600

gctgaggttt atgatacagt ggtcattaca cttaagaaca tggcttccca tcctgtcagt      660

cttcatgctg ttggtgtatc ctactggaaa gcttctgagg gagctgaata tgatgatcag      720

accagtcaaa gggagaaaga agatgataaa gtcttccctg gtggaagcca tacatatgtc      780

tggcaggtcc tgaaagagaa tggtccaatg gcctctgacc cactgtgcct tacctactca      840

tatctttctc atgtggacct ggtaaaagac ttgaattcag gcctcattgg agccctacta      900

gtatgtagag aagggagtct ggccaaggaa aagacacaga ccttgcacaa atttatacta      960

ctttttgctg tatttgatga agggaaaagt tggcactcag aaacaaagaa ctccttgatg     1020

caggataggg atgctgcatc tgctcgggcc tggcctaaaa tgcacacagt caatggttat     1080

gtaaacaggt ctctgccagg tctgattgga tgccacagga aatcagtcta ttggcatgtg     1140

attggaatgg gcaccactcc tgaagtgcac tcaatattcc tcgaaggtca cacatttctt     1200

gtgaggaacc atcgccaggc gtccttggaa atctcgccaa taactttcct tactgctcaa     1260

acactcttga tggaccttgg acagtttcta ctgttttgtc atatctcttc ccaccaacat     1320

gatggcatgg aagcttatgt caaagtagac agctgtccag aggaacccca actacgaatg     1380

aaaaataatg aagaagcgga agactatgat gatgatctta ctgattctga aatggatgtg     1440

gtcaggtttg atgatgacaa ctctccttcc tttatccaaa ttcgctcagt tgccaagaag     1500

catcctaaaa cttgggtaca ttacattgct gctgaagagg aggactggga ctatgctccc     1560

ttagtcctcg cccccgatga cagaagttat aaaagtcaat atttgaacaa tggccctcag     1620

cggattggta ggaagtacaa aaaagtccga tttatggcat acacagatga aacctttaag     1680

actcgtgaag ctattcagca tgaatcagga atcttgggac ctttacttta tggggaagtt     1740

ggagacacac tgttgattat atttaagaat caagcaagca gaccatataa catctaccct     1800

cacggaatca ctgatgtccg tcctttgtat tcaaggagat taccaaaagg tgtaaaacat     1860

ttgaaggatt ttccaattct gccaggagaa atattcaaat ataaatggac agtgactgta     1920

gaagatgggc caactaaatc agatcctcgg tgcctgaccc gctattactc tagtttcgtt     1980

aatatggaga gagatctagc ttcaggactc attggccctc tcctcatctg ctacaaagaa     2040

tctgtagatc aaagaggaaa ccagataatg tcagacaaga ggaatgtcat cctgttttct     2100

gtatttgatg agaaccgaag ctggtacctc acagagaata tacaacgctt tctccccaat     2160

ccagctggag tgcagcttga ggatccagag ttccaagcct ccaacatcat gcacagcatc     2220

aatggctatg tttttgatag tttgcagttg tcagtttgtt tgcatgaggt ggcatactgg     2280

tacattctaa gcattggagc acagactgac ttcctttctg tcttcttctc tggatatacc     2340

ttcaaacaca aaatggtcta tgaagacaca ctcaccctat tcccattctc aggagaaact     2400

gtcttcatgt cgatggaaaa cccaggtttg tttatgcatc cttttttaaa atacattgag     2460

tatgcttgcc ttttagatat agaaatatct gatgctgtct tcttcactaa attttgatta     2520

catgatttga cagcaatatt gaagagtcta acagccagca cgcaggttgg taagtactgt     2580

gggaacatca cagattttgg ctccatgccc taaagagaaa ttggctttca gattatttgg     2640

attaaaaaca aagactttct taagagatgt aaaattttca tgatgttttc ttttttgcta     2700

aaactaaaga attaacgcgt attcttttac atttcaggtc tatggattct ggggtgccac     2760

aactcagact ttcggaacag aggcatgacc gccttactga aggtttctag ttgtgacaag     2820

aacactggtg attattacga ggacagttat gaagatattt cagcatactt gctgagtaaa     2880

aacaatgcca ttgaaccaag agaagagaaa ccctgtggtt ttcctcatgt ggaaaatgga     2940

agaattgccc aatattacta tacttttaaa agcttttact ttccaatgag catagacaaa     3000

aaattgtcat ttttctgctt ggctggttat accactgaaa gtggaagaca agaagagcaa     3060

accacgtgta ccaccgaggg atggtccccc gagcctcggt gcttcaagaa gtgcaccaag     3120

cccgacctgt ccaatggcta catctccgac gtgaagctgc tgtacaagat ccaagaaaac     3180

atgcactacg gctgcgcctc cggctacaag accaccggcg gaaaggacga agaggtggtg     3240

cagtgcctgt ccgacggctg gtcctctcag cctacctgcc ggaaagagca cgagacttgc     3300

ctggcccccg agctgtacaa cggcaactac tccaccaccc agaaaacctt caaagtgaag     3360

gacaaggtgc agtacgagtg tgccaccggg tactacacag ctggcggcaa gaaaactgaa     3420

gaggtggaat gcctgaccta tggctggtcc ctgaccccca agtgtaccaa gctgaagtgc     3480

tcctccctgc ggctgatcga gaacggctac ttccaccccg tgaagcagac ctacgaagag     3540

ggcgacgtgg tgcagttctt ctgccacgag aactactacc tgtccggctc cgacctgatc     3600

cagtgctaca acttcggctg gtatcccgag tcccccgtgt gcgagggcag acggaacagg     3660

tgcccccctc cacccctgcc catcaactcc aagatccaga cccacagcac cacctaccgg     3720

cacggcgaga tcgtgcacat cgagtgcgag ctgaacttcg agatccacgg ctccgccgag     3780

atcagatgcg aggacggcaa gtggacagag ccccccaagt gcatcgaggg ccaagaaaag     3840

gtggcctgcg aggaaccccc cttcatcgaa aacggcgctg ccaacctgca cagcaagatc     3900

tactacaacg gcgacaaggt gacctacgcc tgcaagtccg gctatctgct gcacggcagc     3960

aacgagatca cctgtaaccg gggaaagtgg accctgcccc ctgagtgcgt ggaaaacaac     4020

gagaactgca agcacccccc cgtggtgatg aatggcgccg tggccgatgg catcctggcc     4080

tcttacgcca ccggctcctc cgtggaatac cggtgcaacg agtactacct gctgcggggc     4140

tccaagatct cccgctgcga gcagggcaag tggtctagcc cccctgtgtg cctggaaccc     4200

tgcaccgtga acgtggacta tatgaaccgg aacaatatcg agatgaagtg gaagtatgag     4260

ggcaaggtgc tgcatggcga cctgatcgac ttcgtgtgca agcagggcta cgacctgtcc     4320

cccctgaccc ctctgtccga gctgtccgtg cagtgcaacc ggggcgaagt gaagtacccc     4380

ctgtgcaccc ggaaagaatc caagggcatg tgcacctccc cacccctgat caagcacggc     4440

gtgatcatca gcagcaccgt ggacacctac gagaatggca gctctgtgga atatcgctgc     4500

ttcgaccacc actttctgga aggctccaga gaggcctact gcctggacgg aatgtggacc     4560

acccctcctc tgtgtctgga accttgtacc ctgtccttca ccgagatgga aaagaacaac     4620

ctgctgctga agtgggactt cgacaaccgg ccccacatcc tgcacggcga gtacatcgag     4680

ttcatctgca gaggcgacac ctaccccgct gagctgtaca tcaccggctc catcctgcgg     4740

atgcagtgcg acagaggcca gctgaagtac cctagatgca tcccccggca gagcaccctg     4800

agctaccaag aacccctgcg gaccagacgt cgacgagaaa taactcgtac tactcttcag     4860

tcagatcaag aggaaattga ctatgatgat accatatcag ttgaaatgaa gaaggaagat     4920

tttgacattt atgatgagga tgaaaatcag agcccccgca gctttcaaaa gaaaacacga     4980

cactatttta ttgctgcagt ggagaggctc tgggattatg ggatgagtag ctccccacat     5040

gttctaagaa acagggctca gagtggcagt gtccctcagt tcaagaaagt tgttttccag     5100

gaatttactg atggctcctt tactcagccc ttataccgtg gagaactaaa tgaacatttg     5160

ggactcctgg ggccatatat aagagcagaa gttgaagata atatcatggt aactttcaga     5220

aatcaggcct ctcgtcccta ttccttctat tctagcctta tttcttatga ggaagatcag     5280

aggcaaggag cagaacctag aaaaaacttt gtcaagccta atgaaaccaa aacttacttt     5340

tggaaagtgc aacatcatat ggcacccact aaagatgagt ttgactgcaa agcctgggct     5400

tatttctctg atgttgacct ggaaaaagat gtgcactcag gcctgattgg accccttctg     5460

gtctgccaca ctaacacact gaaccctgct catgggagac aagtgacagt acaggaattt     5520

gctctgtttt tcaccatctt tgatgagacc aaaagctggt acttcactga aaatatggaa     5580

agaaactgca gggctccctg caatatccag atggaagatc ccacttttaa agagaattat     5640

cgcttccatg caatcaatgg ctacataatg gatacactac ctggcttagt aatggctcag     5700

gatcaaagga ttcgatggta tctgctcagc atgggcagca atgaaaacat ccattctatt     5760

catttcagtg gacatgtgtt cactgtacga aaaaaagagg agtataaaat ggcactgtac     5820

aatctctatc caggtgtttt tgagacagtg gaaatgttac catccaaagc tggaatttgg     5880

cgggtggaat gccttattgg cgagcatcta catgctggga tgagcacact ttttctggtg     5940

tacagcaata agtgtcagac tcccctggga atggcttctg gacacattag agattttcag     6000

attacagctt caggacaata tggacagtgg gccccaaagc tggccagact tcattattcc     6060

ggatcaatca atgcctggag caccaaggag cccttttctt ggatcaaggt ggatctgttg     6120

gcaccaatga ttattcacgg catcaagacc cagggtgccc gtcagaagtt ctccagcctc     6180

tacatctctc agtttatcat catgtatagt cttgatggga agaagtggca gacttatcga     6240

ggaaattcca ctggaacctt aatggtcttc tttggcaatg tggattcatc tgggataaaa     6300

cacaatattt ttaaccctcc aattattgct cgatacatcc gtttgcaccc aactcattat     6360

agcattcgca gcactcttcg catggagttg atgggctgtg atttaaatag ttgcagcatg     6420

ccattgggaa tggagagtaa agcaatatca gatgcacaga ttactgcttc atcctacttt     6480

accaatatgt ttgccacctg gtctccttca aaagctcgac ttcacctcca agggaggagt     6540

aatgcctgga gacctcaggt gaataatcca aaagagtggc tgcaagtgga cttccagaag     6600

acaatgaaag tcacaggagt aactactcag ggagtaaaat ctctgcttac cagcatgtat     6660

gtgaaggagt tcctcatctc cagcagtcaa gatggccatc agtggactct cttttttcag     6720

aatggcaaag taaaggtttt tcagggaaat caagactcct tcacacctgt ggtgaactct     6780

ctagacccac cgttactgac tcgctacctt cgaattcacc cccagagttg ggtgcaccag     6840

attgccctga ggatggaggt tctgggctgc gaggcacagg acctctactg a              6891



