                         SEQUENCE LISTING

<110>  INTEGRATED BIOTHERAPEUTICS, INC.
 
<120>  IMMUNOGENIC COMPOSITION COMPRISING A FUSION PEPTIDE DERIVED FROM 
       SUPERANTIGEN TOXOIDS

<130>  57783-176965

<150>  US 62/537,706
<151>  2017-07-27

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  195
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  SIMILAR
<222>  (1)..(195)
<223>  TSST-1 L30R / D27A / I46A

<400>  1

Met Ser Thr Asn Asp Asn Ile Lys Asp Leu Leu Asp Trp Tyr Ser Ser 
1               5                   10                  15      


Gly Ser Asp Thr Phe Thr Asn Ser Glu Val Leu Ala Asn Ser Arg Gly 
            20                  25                  30          


Ser Met Arg Ile Lys Asn Thr Asp Gly Ser Ile Ser Leu Ile Ala Phe 
        35                  40                  45              


Pro Ser Pro Tyr Tyr Ser Pro Ala Phe Thr Lys Gly Glu Lys Val Asp 
    50                  55                  60                  


Leu Asn Thr Lys Arg Thr Lys Lys Ser Gln His Thr Ser Glu Gly Thr 
65                  70                  75                  80  


Tyr Ile His Phe Gln Ile Ser Gly Val Thr Asn Thr Glu Lys Leu Pro 
                85                  90                  95      


Thr Pro Ile Glu Leu Pro Leu Lys Val Lys Val His Gly Lys Asp Ser 
            100                 105                 110         


Pro Leu Lys Tyr Trp Pro Lys Phe Asp Lys Lys Gln Leu Ala Ile Ser 
        115                 120                 125             


Thr Leu Asp Phe Glu Ile Arg His Gln Leu Thr Gln Ile His Gly Leu 
    130                 135                 140                 


Tyr Arg Ser Ser Asp Lys Thr Gly Gly Tyr Trp Lys Ile Thr Met Asn 
145                 150                 155                 160 


Asp Gly Ser Thr Tyr Gln Ser Asp Leu Ser Lys Lys Phe Glu Tyr Asn 
                165                 170                 175     


Thr Glu Lys Pro Pro Ile Asn Ile Asp Glu Ile Lys Thr Ile Glu Ala 
            180                 185                 190         


Glu Ile Asn 
        195 


<210>  2
<211>  240
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  SIMILAR
<222>  (1)..(240)
<223>  SEB L45R / Y89A / Y94A

<400>  2

Met Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser 
1               5                   10                  15      


Lys Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn 
            20                  25                  30          


His Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr Phe 
        35                  40                  45              


Asp Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn 
    50                  55                  60                  


Val Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp 
65                  70                  75                  80  


Lys Tyr Val Asp Val Phe Gly Ala Asn Ala Tyr Tyr Gln Cys Ala Phe 
                85                  90                  95      


Ser Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys 
            100                 105                 110         


Thr Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp 
        115                 120                 125             


Lys Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu 
    130                 135                 140                 


Leu Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu 
145                 150                 155                 160 


Leu Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr 
                165                 170                 175     


Glu Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu 
            180                 185                 190         


Asn Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys 
        195                 200                 205             


Phe Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val 
    210                 215                 220                 


Asp Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 240 


<210>  3
<211>  232
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  SIMILAR
<222>  (1)..(232)
<223>  SEA L48R / D70R / Y92A

<400>  3

Glu Lys Ser Glu Glu Ile Asn Glu Lys Asp Leu Arg Lys Lys Ser Glu 
1               5                   10                  15      


Leu Gln Gly Thr Ala Leu Gly Asn Leu Lys Gln Ile Tyr Tyr Tyr Asn 
            20                  25                  30          


Glu Lys Ala Lys Thr Glu Asn Lys Glu Ser His Asp Gln Phe Arg Gln 
        35                  40                  45              


His Thr Ile Leu Phe Lys Gly Phe Phe Thr Asp His Ser Trp Tyr Asn 
    50                  55                  60                  


Asp Leu Leu Val Arg Phe Asp Ser Lys Asp Ile Val Asp Lys Tyr Lys 
65                  70                  75                  80  


Gly Lys Lys Val Asp Leu Tyr Gly Ala Tyr Ala Gly Tyr Gln Cys Ala 
                85                  90                  95      


Gly Gly Thr Pro Asn Lys Thr Ala Cys Met Tyr Gly Gly Val Thr Leu 
            100                 105                 110         


His Asp Asn Asn Arg Leu Thr Glu Glu Lys Lys Val Pro Ile Asn Leu 
        115                 120                 125             


Trp Leu Asp Gly Lys Gln Asn Thr Val Pro Leu Glu Thr Val Lys Thr 
    130                 135                 140                 


Asn Lys Lys Asn Val Thr Val Gln Glu Leu Asp Leu Gln Ala Arg Arg 
145                 150                 155                 160 


Tyr Leu Gln Glu Lys Tyr Asn Leu Tyr Asn Ser Asp Val Phe Asp Gly 
                165                 170                 175     


Lys Val Gln Arg Gly Leu Ile Val Phe His Thr Ser Thr Glu Pro Ser 
            180                 185                 190         


Val Asn Tyr Asp Leu Phe Gly Ala Gln Gly Gln Tyr Ser Asn Thr Leu 
        195                 200                 205             


Leu Arg Ile Tyr Arg Asp Asn Lys Thr Ile Asn Ser Glu Asn Met His 
    210                 215                 220                 


Ile Asp Ile Tyr Leu Tyr Thr Ser 
225                 230         


<210>  4
<211>  232
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  SIMILAR
<222>  (1)..(232)
<223>  SEA L48R / D70R / Y92A / H225A

<400>  4

Glu Lys Ser Glu Glu Ile Asn Glu Lys Asp Leu Arg Lys Lys Ser Glu 
1               5                   10                  15      


Leu Gln Gly Thr Ala Leu Gly Asn Leu Lys Gln Ile Tyr Tyr Tyr Asn 
            20                  25                  30          


Glu Lys Ala Lys Thr Glu Asn Lys Glu Ser His Asp Gln Phe Arg Gln 
        35                  40                  45              


His Thr Ile Leu Phe Lys Gly Phe Phe Thr Asp His Ser Trp Tyr Asn 
    50                  55                  60                  


Asp Leu Leu Val Arg Phe Asp Ser Lys Asp Ile Val Asp Lys Tyr Lys 
65                  70                  75                  80  


Gly Lys Lys Val Asp Leu Tyr Gly Ala Tyr Ala Gly Tyr Gln Cys Ala 
                85                  90                  95      


Gly Gly Thr Pro Asn Lys Thr Ala Cys Met Tyr Gly Gly Val Thr Leu 
            100                 105                 110         


His Asp Asn Asn Arg Leu Thr Glu Glu Lys Lys Val Pro Ile Asn Leu 
        115                 120                 125             


Trp Leu Asp Gly Lys Gln Asn Thr Val Pro Leu Glu Thr Val Lys Thr 
    130                 135                 140                 


Asn Lys Lys Asn Val Thr Val Gln Glu Leu Asp Leu Gln Ala Arg Arg 
145                 150                 155                 160 


Tyr Leu Gln Glu Lys Tyr Asn Leu Tyr Asn Ser Asp Val Phe Asp Gly 
                165                 170                 175     


Lys Val Gln Arg Gly Leu Ile Val Phe His Thr Ser Thr Glu Pro Ser 
            180                 185                 190         


Val Asn Tyr Asp Leu Phe Gly Ala Gln Gly Gln Tyr Ser Asn Thr Leu 
        195                 200                 205             


Leu Arg Ile Tyr Arg Asp Asn Lys Thr Ile Asn Ser Glu Asn Met Ala 
    210                 215                 220                 


Ile Asp Ile Tyr Leu Tyr Thr Ser 
225                 230         


<210>  5
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Ser Thr Asn Asp Asn Ile Lys Asp Leu Leu Asp Trp Tyr Ser Ser 
1               5                   10                  15      


Gly Ser Asp Thr Phe Thr Asn Ser Glu Val Leu Ala Asn Ser Arg Gly 
            20                  25                  30          


Ser Met Arg Ile Lys Asn Thr Asp Gly Ser Ile Ser Leu Ile Ala Phe 
        35                  40                  45              


Pro Ser Pro Tyr Tyr Ser Pro Ala Phe Thr Lys Gly Glu Lys Val Asp 
    50                  55                  60                  


Leu Asn Thr Lys Arg Thr Lys Lys Ser Gln His Thr Ser Glu Gly Thr 
65                  70                  75                  80  


Tyr Ile His Phe Gln Ile Ser Gly Val Thr Asn Thr Glu Lys Leu Pro 
                85                  90                  95      


Thr Pro Ile Glu Leu Pro Leu Lys Val Lys Val His Gly Lys Asp Ser 
            100                 105                 110         


Pro Leu Lys Tyr Trp Pro Lys Phe Asp Lys Lys Gln Leu Ala Ile Ser 
        115                 120                 125             


Thr Leu Asp Phe Glu Ile Arg His Gln Leu Thr Gln Ile His Gly Leu 
    130                 135                 140                 


Tyr Arg Ser Ser Asp Lys Thr Gly Gly Tyr Trp Lys Ile Thr Met Asn 
145                 150                 155                 160 


Asp Gly Ser Thr Tyr Gln Ser Asp Leu Ser Lys Lys Phe Glu Tyr Asn 
                165                 170                 175     


Thr Glu Lys Pro Pro Ile Asn Ile Asp Glu Ile Lys Thr Ile Glu Ala 
            180                 185                 190         


Glu Ile Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser 
    210                 215                 220                 


Ser Lys Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp 
225                 230                 235                 240 


Asn His Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr 
                245                 250                 255     


Phe Asp Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp 
            260                 265                 270         


Asn Val Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys 
        275                 280                 285             


Asp Lys Tyr Val Asp Val Phe Gly Ala Asn Ala Tyr Tyr Gln Cys Ala 
    290                 295                 300                 


Phe Ser Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg 
305                 310                 315                 320 


Lys Thr Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu 
                325                 330                 335     


Asp Lys Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn 
            340                 345                 350         


Leu Leu Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln 
        355                 360                 365             


Glu Leu Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu 
    370                 375                 380                 


Tyr Glu Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile 
385                 390                 395                 400 


Glu Asn Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp 
                405                 410                 415     


Lys Phe Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met 
            420                 425                 430         


Val Asp Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Glu Lys Ser Glu Glu Ile Asn Glu Lys Asp Leu Arg Lys Lys Ser Glu 
465                 470                 475                 480 


Leu Gln Gly Thr Ala Leu Gly Asn Leu Lys Gln Ile Tyr Tyr Tyr Asn 
                485                 490                 495     


Glu Lys Ala Lys Thr Glu Asn Lys Glu Ser His Asp Gln Phe Arg Gln 
            500                 505                 510         


His Thr Ile Leu Phe Lys Gly Phe Phe Thr Asp His Ser Trp Tyr Asn 
        515                 520                 525             


Asp Leu Leu Val Arg Phe Asp Ser Lys Asp Ile Val Asp Lys Tyr Lys 
    530                 535                 540                 


Gly Lys Lys Val Asp Leu Tyr Gly Ala Tyr Ala Gly Tyr Gln Cys Ala 
545                 550                 555                 560 


Gly Gly Thr Pro Asn Lys Thr Ala Cys Met Tyr Gly Gly Val Thr Leu 
                565                 570                 575     


His Asp Asn Asn Arg Leu Thr Glu Glu Lys Lys Val Pro Ile Asn Leu 
            580                 585                 590         


Trp Leu Asp Gly Lys Gln Asn Thr Val Pro Leu Glu Thr Val Lys Thr 
        595                 600                 605             


Asn Lys Lys Asn Val Thr Val Gln Glu Leu Asp Leu Gln Ala Arg Arg 
    610                 615                 620                 


Tyr Leu Gln Glu Lys Tyr Asn Leu Tyr Asn Ser Asp Val Phe Asp Gly 
625                 630                 635                 640 


Lys Val Gln Arg Gly Leu Ile Val Phe His Thr Ser Thr Glu Pro Ser 
                645                 650                 655     


Val Asn Tyr Asp Leu Phe Gly Ala Gln Gly Gln Tyr Ser Asn Thr Leu 
            660                 665                 670         


Leu Arg Ile Tyr Arg Asp Asn Lys Thr Ile Asn Ser Glu Asn Met His 
        675                 680                 685             


Ile Asp Ile Tyr Leu Tyr Thr Ser 
    690                 695     


<210>  6
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Ser Thr Asn Asp Asn Ile Lys Asp Leu Leu Asp Trp Tyr Ser Ser 
1               5                   10                  15      


Gly Ser Asp Thr Phe Thr Asn Ser Glu Val Leu Ala Asn Ser Arg Gly 
            20                  25                  30          


Ser Met Arg Ile Lys Asn Thr Asp Gly Ser Ile Ser Leu Ile Ala Phe 
        35                  40                  45              


Pro Ser Pro Tyr Tyr Ser Pro Ala Phe Thr Lys Gly Glu Lys Val Asp 
    50                  55                  60                  


Leu Asn Thr Lys Arg Thr Lys Lys Ser Gln His Thr Ser Glu Gly Thr 
65                  70                  75                  80  


Tyr Ile His Phe Gln Ile Ser Gly Val Thr Asn Thr Glu Lys Leu Pro 
                85                  90                  95      


Thr Pro Ile Glu Leu Pro Leu Lys Val Lys Val His Gly Lys Asp Ser 
            100                 105                 110         


Pro Leu Lys Tyr Trp Pro Lys Phe Asp Lys Lys Gln Leu Ala Ile Ser 
        115                 120                 125             


Thr Leu Asp Phe Glu Ile Arg His Gln Leu Thr Gln Ile His Gly Leu 
    130                 135                 140                 


Tyr Arg Ser Ser Asp Lys Thr Gly Gly Tyr Trp Lys Ile Thr Met Asn 
145                 150                 155                 160 


Asp Gly Ser Thr Tyr Gln Ser Asp Leu Ser Lys Lys Phe Glu Tyr Asn 
                165                 170                 175     


Thr Glu Lys Pro Pro Ile Asn Ile Asp Glu Ile Lys Thr Ile Glu Ala 
            180                 185                 190         


Glu Ile Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser 
    210                 215                 220                 


Ser Lys Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp 
225                 230                 235                 240 


Asn His Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Arg Tyr 
                245                 250                 255     


Phe Asp Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp 
            260                 265                 270         


Asn Val Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys 
        275                 280                 285             


Asp Lys Tyr Val Asp Val Phe Gly Ala Asn Ala Tyr Tyr Gln Cys Ala 
    290                 295                 300                 


Phe Ser Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg 
305                 310                 315                 320 


Lys Thr Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu 
                325                 330                 335     


Asp Lys Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn 
            340                 345                 350         


Leu Leu Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln 
        355                 360                 365             


Glu Leu Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu 
    370                 375                 380                 


Tyr Glu Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile 
385                 390                 395                 400 


Glu Asn Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp 
                405                 410                 415     


Lys Phe Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met 
            420                 425                 430         


Val Asp Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Glu Lys Ser Glu Glu Ile Asn Glu Lys Asp Leu Arg Lys Lys Ser Glu 
465                 470                 475                 480 


Leu Gln Gly Thr Ala Leu Gly Asn Leu Lys Gln Ile Tyr Tyr Tyr Asn 
                485                 490                 495     


Glu Lys Ala Lys Thr Glu Asn Lys Glu Ser His Asp Gln Phe Arg Gln 
            500                 505                 510         


His Thr Ile Leu Phe Lys Gly Phe Phe Thr Asp His Ser Trp Tyr Asn 
        515                 520                 525             


Asp Leu Leu Val Arg Phe Asp Ser Lys Asp Ile Val Asp Lys Tyr Lys 
    530                 535                 540                 


Gly Lys Lys Val Asp Leu Tyr Gly Ala Tyr Ala Gly Tyr Gln Cys Ala 
545                 550                 555                 560 


Gly Gly Thr Pro Asn Lys Thr Ala Cys Met Tyr Gly Gly Val Thr Leu 
                565                 570                 575     


His Asp Asn Asn Arg Leu Thr Glu Glu Lys Lys Val Pro Ile Asn Leu 
            580                 585                 590         


Trp Leu Asp Gly Lys Gln Asn Thr Val Pro Leu Glu Thr Val Lys Thr 
        595                 600                 605             


Asn Lys Lys Asn Val Thr Val Gln Glu Leu Asp Leu Gln Ala Arg Arg 
    610                 615                 620                 


Tyr Leu Gln Glu Lys Tyr Asn Leu Tyr Asn Ser Asp Val Phe Asp Gly 
625                 630                 635                 640 


Lys Val Gln Arg Gly Leu Ile Val Phe His Thr Ser Thr Glu Pro Ser 
                645                 650                 655     


Val Asn Tyr Asp Leu Phe Gly Ala Gln Gly Gln Tyr Ser Asn Thr Leu 
            660                 665                 670         


Leu Arg Ile Tyr Arg Asp Asn Lys Thr Ile Asn Ser Glu Asn Met Ala 
        675                 680                 685             


Ile Asp Ile Tyr Leu Tyr Thr Ser 
    690                 695     


<210>  7
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atgtcgacga atgacaacat caaagacctg ctggactggt actcctcggg ctcggatacg       60

ttcacgaata gcgaagtgct ggcaaactca cgcggtagca tgcgtatcaa aaataccgat      120

ggtagcatta gcctgatcgc ttttccgtca ccgtattaca gcccggcatt caccaaaggc      180

gaaaaagtgg atctgaatac caaacgcacg aaaaaatcac agcatacctc agaaggtacc      240

tacatccact ttcagatcag cggcgtgacc aacaccgaaa aactgccgac cccgattgaa      300

ctgccgctga aagtgaaagt tcatggcaaa gattcgccgc tgaaatattg gccgaaattt      360

gataaaaaac agctggcaat ttcgaccctg gatttcgaaa ttcgccacca gctgacccag      420

atccatggtc tgtaccgttc aagcgacaaa accggcggtt attggaaaat caccatgaat      480

gatggttcga cgtaccagag cgatctgtcg aaaaaattcg aatacaacac ggaaaaaccg      540

ccgattaata tcgatgaaat caaaaccatc gaagcggaaa tcaatggcgg tggcggctcg      600

ggtggtggcg gtagcggtgg cggcggtagt gaatcgcaac cggatccgaa accggacgaa      660

ctgcacaaat cgtccaaatt taccggtctg atggaaaata tgaaagtgct gtatgatgac      720

aaccatgtgt cggcaattaa cgtgaaaagc atcgatcagt ttcgctattt cgatctgatc      780

tatagcatta aagatacgaa actgggtaat tacgataacg ttcgtgtgga atttaaaaac      840

aaagatctgg cggacaaata taaagacaaa tacgtggacg ttttcggtgc gaatgcgtat      900

taccaatgcg cctttagcaa aaagaccaat gatatcaact cccatcagac cgacaaacgt      960

aaaacctgca tgtacggtgg tgtgaccgaa cataacggta atcagctgga caaatatcgt     1020

agcatcacgg tccgtgtgtt tgaagacggc aaaaacctgc tgtcatttga tgttcagacg     1080

aacaaaaaga aagttacggc tcaagaactg gattacctga cccgccacta tctggtgaaa     1140

aataaaaaac tgtacgaatt taacaatagc ccgtacgaaa ccggctacat caaattcatt     1200

gaaaatgaaa atagcttttg gtacgatatg atgccggcac cgggtgacaa atttgaccaa     1260

agcaaatacc tgatgatgta caacgataac aaaatggtcg attcaaaaga cgtgaaaatc     1320

gaagtctatc tgacgaccaa aaagaaaggt ggcggtggtt ctggtggtgg tggctcgggc     1380

ggcggtggct cggaaaaatc cgaagaaatt aacgaaaaag acctgcgtaa aaaatccgaa     1440

ctgcagggta cggcgctggg taatctgaaa cagatttatt actacaacga aaaagccaaa     1500

accgaaaaca aagaaagcca tgatcagttc cgccagcata cgatcctgtt caaaggcttt     1560

ttcaccgatc attcgtggta taatgacctg ctggtgcgtt tcgatagcaa agacattgtg     1620

gataaatata aaggcaaaaa agtggatctg tatggcgcat acgctggtta tcagtgtgcg     1680

ggcggtacgc cgaataaaac ggcatgcatg tatggtggtg tgacgctgca tgacaataac     1740

cgcctgaccg aagaaaagaa agtgccgatt aatctgtggc tggacggtaa acagaacacc     1800

gtgccgctgg aaacggtgaa aaccaataaa aagaacgtga ccgtgcagga actggacctg     1860

caagcacgcc gttatctgca ggaaaaatat aacctgtata acagcgacgt gttcgatggc     1920

aaagtgcagc gtggtctgat cgtcttccat accagcaccg aaccgagcgt taactatgac     1980

ctgtttggcg cacaaggcca gtactccaat accctgctgc gcatttatcg cgataacaaa     2040

accattaact ccgaaaacat gcacattgac atttacctgt acacctcgta acatcatcac     2100

catcattgat aataa                                                      2115


<210>  8
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
atgtcgacga atgacaacat caaagacctg ctggactggt actcctcggg ctcggatacg       60

ttcacgaata gcgaagtgct ggcaaactca cgcggtagca tgcgtatcaa aaataccgat      120

ggtagcatta gcctgatcgc ttttccgtca ccgtattaca gcccggcatt caccaaaggc      180

gaaaaagtgg atctgaatac caaacgcacg aaaaaatcac agcatacctc agaaggtacc      240

tacatccact ttcagatcag cggcgtgacc aacaccgaaa aactgccgac cccgattgaa      300

ctgccgctga aagtgaaagt tcatggcaaa gattcgccgc tgaaatattg gccgaaattt      360

gataaaaaac agctggcaat ttcgaccctg gatttcgaaa ttcgccacca gctgacccag      420

atccatggtc tgtaccgttc aagcgacaaa accggcggtt attggaaaat caccatgaat      480

gatggttcga cgtaccagag cgatctgtcg aaaaaattcg aatacaacac ggaaaaaccg      540

ccgattaata tcgatgaaat caaaaccatc gaagcggaaa tcaatggcgg tggcggctcg      600

ggtggtggcg gtagcggtgg cggcggtagt gaatcgcaac cggatccgaa accggacgaa      660

ctgcacaaat cgtccaaatt taccggtctg atggaaaata tgaaagtgct gtatgatgac      720

aaccatgtgt cggcaattaa cgtgaaaagc atcgatcagt ttcgctattt cgatctgatc      780

tatagcatta aagatacgaa actgggtaat tacgataacg ttcgtgtgga atttaaaaac      840

aaagatctgg cggacaaata taaagacaaa tacgtggacg ttttcggtgc gaatgcgtat      900

taccaatgcg cctttagcaa aaagaccaat gatatcaact cccatcagac cgacaaacgt      960

aaaacctgca tgtacggtgg tgtgaccgaa cataacggta atcagctgga caaatatcgt     1020

agcatcacgg tccgtgtgtt tgaagacggc aaaaacctgc tgtcatttga tgttcagacg     1080

aacaaaaaga aagttacggc tcaagaactg gattacctga cccgccacta tctggtgaaa     1140

aataaaaaac tgtacgaatt taacaatagc ccgtacgaaa ccggctacat caaattcatt     1200

gaaaatgaaa atagcttttg gtacgatatg atgccggcac cgggtgacaa atttgaccaa     1260

agcaaatacc tgatgatgta caacgataac aaaatggtcg attcaaaaga cgtgaaaatc     1320

gaagtctatc tgacgaccaa aaagaaaggt ggcggtggtt ctggtggtgg tggctcgggc     1380

ggcggtggct cggaaaaatc cgaagaaatt aacgaaaaag acctgcgtaa aaaatccgaa     1440

ctgcagggta cggcgctggg taatctgaaa cagatttatt actacaacga aaaagccaaa     1500

accgaaaaca aagaaagcca tgatcagttc cgccagcata cgatcctgtt caaaggcttt     1560

ttcaccgatc attcgtggta taatgacctg ctggtgcgtt tcgatagcaa agacattgtg     1620

gataaatata aaggcaaaaa agtggatctg tatggcgcat acgctggtta tcagtgtgcg     1680

ggcggtacgc cgaataaaac ggcatgcatg tatggtggtg tgacgctgca tgacaataac     1740

cgcctgaccg aagaaaagaa agtgccgatt aatctgtggc tggacggtaa acagaacacc     1800

gtgccgctgg aaacggtgaa aaccaataaa aagaacgtga ccgtgcagga actggacctg     1860

caagcacgcc gttatctgca ggaaaaatat aacctgtata acagcgacgt gttcgatggc     1920

aaagtgcagc gtggtctgat cgtcttccat accagcaccg aaccgagcgt taactatgac     1980

ctgtttggcg cacaaggcca gtactccaat accctgctgc gcatttatcg cgataacaaa     2040

accattaact ccgaaaacat ggccattgac atttacctgt acacctcgta acatcatcac     2100

catcattgat aataa                                                      2115


<210>  9
<211>  195
<212>  PRT
<213>  Staphylococcus aureus

<400>  9

Met Ser Thr Asn Asp Asn Ile Lys Asp Leu Leu Asp Trp Tyr Ser Ser 
1               5                   10                  15      


Gly Ser Asp Thr Phe Thr Asn Ser Glu Val Leu Asp Asn Ser Leu Gly 
            20                  25                  30          


Ser Met Arg Ile Lys Asn Thr Asp Gly Ser Ile Ser Leu Ile Ile Phe 
        35                  40                  45              


Pro Ser Pro Tyr Tyr Ser Pro Ala Phe Thr Lys Gly Glu Lys Val Asp 
    50                  55                  60                  


Leu Asn Thr Lys Arg Thr Lys Lys Ser Gln His Thr Ser Glu Gly Thr 
65                  70                  75                  80  


Tyr Ile His Phe Gln Ile Ser Gly Val Thr Asn Thr Glu Lys Leu Pro 
                85                  90                  95      


Thr Pro Ile Glu Leu Pro Leu Lys Val Lys Val His Gly Lys Asp Ser 
            100                 105                 110         


Pro Leu Lys Tyr Trp Pro Lys Phe Asp Lys Lys Gln Leu Ala Ile Ser 
        115                 120                 125             


Thr Leu Asp Phe Glu Ile Arg His Gln Leu Thr Gln Ile His Gly Leu 
    130                 135                 140                 


Tyr Arg Ser Ser Asp Lys Thr Gly Gly Tyr Trp Lys Ile Thr Met Asn 
145                 150                 155                 160 


Asp Gly Ser Thr Tyr Gln Ser Asp Leu Ser Lys Lys Phe Glu Tyr Asn 
                165                 170                 175     


Thr Glu Lys Pro Pro Ile Asn Ile Asp Glu Ile Lys Thr Ile Glu Ala 
            180                 185                 190         


Glu Ile Asn 
        195 


<210>  10
<211>  240
<212>  PRT
<213>  Staphylococcus aureus

<400>  10

Met Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser 
1               5                   10                  15      


Lys Phe Thr Gly Leu Met Glu Asn Met Lys Val Leu Tyr Asp Asp Asn 
            20                  25                  30          


His Val Ser Ala Ile Asn Val Lys Ser Ile Asp Gln Phe Leu Tyr Phe 
        35                  40                  45              


Asp Leu Ile Tyr Ser Ile Lys Asp Thr Lys Leu Gly Asn Tyr Asp Asn 
    50                  55                  60                  


Val Arg Val Glu Phe Lys Asn Lys Asp Leu Ala Asp Lys Tyr Lys Asp 
65                  70                  75                  80  


Lys Tyr Val Asp Val Phe Gly Ala Asn Tyr Tyr Tyr Gln Cys Tyr Phe 
                85                  90                  95      


Ser Lys Lys Thr Asn Asp Ile Asn Ser His Gln Thr Asp Lys Arg Lys 
            100                 105                 110         


Thr Cys Met Tyr Gly Gly Val Thr Glu His Asn Gly Asn Gln Leu Asp 
        115                 120                 125             


Lys Tyr Arg Ser Ile Thr Val Arg Val Phe Glu Asp Gly Lys Asn Leu 
    130                 135                 140                 


Leu Ser Phe Asp Val Gln Thr Asn Lys Lys Lys Val Thr Ala Gln Glu 
145                 150                 155                 160 


Leu Asp Tyr Leu Thr Arg His Tyr Leu Val Lys Asn Lys Lys Leu Tyr 
                165                 170                 175     


Glu Phe Asn Asn Ser Pro Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Glu 
            180                 185                 190         


Asn Glu Asn Ser Phe Trp Tyr Asp Met Met Pro Ala Pro Gly Asp Lys 
        195                 200                 205             


Phe Asp Gln Ser Lys Tyr Leu Met Met Tyr Asn Asp Asn Lys Met Val 
    210                 215                 220                 


Asp Ser Lys Asp Val Lys Ile Glu Val Tyr Leu Thr Thr Lys Lys Lys 
225                 230                 235                 240 


<210>  11
<211>  232
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  SIMILAR
<222>  (1)..(232)
<223>  SEA H225A

<400>  11

Glu Lys Ser Glu Glu Ile Asn Glu Lys Asp Leu Arg Lys Lys Ser Glu 
1               5                   10                  15      


Leu Gln Gly Thr Ala Leu Gly Asn Leu Lys Gln Ile Tyr Tyr Tyr Asn 
            20                  25                  30          


Glu Lys Ala Lys Thr Glu Asn Lys Glu Ser His Asp Gln Phe Leu Gln 
        35                  40                  45              


His Thr Ile Leu Phe Lys Gly Phe Phe Thr Asp His Ser Trp Tyr Asn 
    50                  55                  60                  


Asp Leu Leu Val Asp Phe Asp Ser Lys Asp Ile Val Asp Lys Tyr Lys 
65                  70                  75                  80  


Gly Lys Lys Val Asp Leu Tyr Gly Ala Tyr Tyr Gly Tyr Gln Cys Ala 
                85                  90                  95      


Gly Gly Thr Pro Asn Lys Thr Ala Cys Met Tyr Gly Gly Val Thr Leu 
            100                 105                 110         


His Asp Asn Asn Arg Leu Thr Glu Glu Lys Lys Val Pro Ile Asn Leu 
        115                 120                 125             


Trp Leu Asp Gly Lys Gln Asn Thr Val Pro Leu Glu Thr Val Lys Thr 
    130                 135                 140                 


Asn Lys Lys Asn Val Thr Val Gln Glu Leu Asp Leu Gln Ala Arg Arg 
145                 150                 155                 160 


Tyr Leu Gln Glu Lys Tyr Asn Leu Tyr Asn Ser Asp Val Phe Asp Gly 
                165                 170                 175     


Lys Val Gln Arg Gly Leu Ile Val Phe His Thr Ser Thr Glu Pro Ser 
            180                 185                 190         


Val Asn Tyr Asp Leu Phe Gly Ala Gln Gly Gln Tyr Ser Asn Thr Leu 
        195                 200                 205             


Leu Arg Ile Tyr Arg Asp Asn Lys Thr Ile Asn Ser Glu Asn Met Ala 
    210                 215                 220                 


Ile Asp Ile Tyr Leu Tyr Thr Ser 
225                 230         


<210>  12
<211>  232
<212>  PRT
<213>  Staphylococcus aureus

<400>  12

Glu Lys Ser Glu Glu Ile Asn Glu Lys Asp Leu Arg Lys Lys Ser Glu 
1               5                   10                  15      


Leu Gln Gly Thr Ala Leu Gly Asn Leu Lys Gln Ile Tyr Tyr Tyr Asn 
            20                  25                  30          


Glu Lys Ala Lys Thr Glu Asn Lys Glu Ser His Asp Gln Phe Leu Gln 
        35                  40                  45              


His Thr Ile Leu Phe Lys Gly Phe Phe Thr Asp His Ser Trp Tyr Asn 
    50                  55                  60                  


Asp Leu Leu Val Asp Phe Asp Ser Lys Asp Ile Val Asp Lys Tyr Lys 
65                  70                  75                  80  


Gly Lys Lys Val Asp Leu Tyr Gly Ala Tyr Tyr Gly Tyr Gln Cys Ala 
                85                  90                  95      


Gly Gly Thr Pro Asn Lys Thr Ala Cys Met Tyr Gly Gly Val Thr Leu 
            100                 105                 110         


His Asp Asn Asn Arg Leu Thr Glu Glu Lys Lys Val Pro Ile Asn Leu 
        115                 120                 125             


Trp Leu Asp Gly Lys Gln Asn Thr Val Pro Leu Glu Thr Val Lys Thr 
    130                 135                 140                 


Asn Lys Lys Asn Val Thr Val Gln Glu Leu Asp Leu Gln Ala Arg Arg 
145                 150                 155                 160 


Tyr Leu Gln Glu Lys Tyr Asn Leu Tyr Asn Ser Asp Val Phe Asp Gly 
                165                 170                 175     


Lys Val Gln Arg Gly Leu Ile Val Phe His Thr Ser Thr Glu Pro Ser 
            180                 185                 190         


Val Asn Tyr Asp Leu Phe Gly Ala Gln Gly Gln Tyr Ser Asn Thr Leu 
        195                 200                 205             


Leu Arg Ile Tyr Arg Asp Asn Lys Thr Ile Asn Ser Glu Asn Met His 
    210                 215                 220                 


Ile Asp Ile Tyr Leu Tyr Thr Ser 
225                 230         


