                         SEQUENCE LISTING

<110>  CELGENE CORPORATION
 
<120>  METHOD OF PREPARING OLIGONUCLEOTIDE COMPOUNDS

<130>  14247-109-228

<140>  PCT/US2018/043867
<141>  2018-07-26

<150>  US 62/538,504
<151>  2017-07-28

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1281
<212>  DNA
<213>  Homo sapiens

<220>
<223>  human SMAD family member 7 (SMAD7)

<400>  1
atgttcagga ccaaacgatc tgcgctcgtc cggcgtctct ggaggagccg tgcgcccggc       60

ggcgaggacg aggaggaggg cgcaggggga ggtggaggag gaggcgagct gcggggagaa      120

ggggcgacgg acagccgagc gcatggggcc ggtggcggcg gcccgggcag ggctggatgc      180

tgcctgggca aggcggtgcg aggtgccaaa ggtcaccacc atccccaccc gccagccgcg      240

ggcgccggcg cggccggggg cgccgaggcg gatctgaagg cgctcacgca ctcggtgctc      300

aagaaactga aggagcggca gctggagctg ctgctccagg ccgtggagtc ccgcggcggg      360

acgcgcaccg cgtgcctcct gctgcccggc cgcctggact gcaggctggg cccgggggcg      420

cccgccggcg cgcagcctgc gcagccgccc tcgtcctact cgctccccct cctgctgtgc      480

aaagtgttca ggtggccgga tctcaggcat tcctcggaag tcaagaggct gtgttgctgt      540

gaatcttacg ggaagatcaa ccccgagctg gtgtgctgca acccccatca ccttagccga      600

ctctgcgaac tagagtctcc cccccctcct tactccagat acccgatgga ttttctcaaa      660

ccaactgcag actgtccaga tgctgtgcct tcctccgctg aaacaggggg aacgaattat      720

ctggcccctg gggggctttc agattcccaa cttcttctgg agcctgggga tcggtcacac      780

tggtgcgtgg tggcatactg ggaggagaag acgagagtgg ggaggctcta ctgtgtccag      840

gagccctctc tggatatctt ctatgatcta cctcagggga atggcttttg cctcggacag      900

ctcaattcgg acaacaagag tcagctggtg cagaaggtgc ggagcaaaat cggctgcggc      960

atccagctga cgcgggaggt ggatggtgtg tgggtgtaca accgcagcag ttaccccatc     1020

ttcatcaagt ccgccacact ggacaacccg gactccagga cgctgttggt acacaaggtg     1080

ttccccggtt tctccatcaa ggctttcgac tacgagaagg cgtacagcct gcagcggccc     1140

aatgaccacg agtttatgca gcagccgtgg acgggcttta ccgtgcagat cagctttgtg     1200

aagggctggg gccagtgcta cacccgccag ttcatcagca gctgcccgtg ctggctagag     1260

gtcatcttca acagccggta g                                               1281


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n represents a nucleotide comprising a nitrogenous base 
selected from the group consisting of cytosine, 
5-methylcytosine and 2'-O-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n represents a nucleotide comprising a nitrogenous base 
selected from the group consisting of guanine, 
5-methylguanine, or 2'-O-methylguanine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n represents a nucleotide comprising a nitrogenous base 
selected from the group consisting of cytosine, 
5-methylcytosine and 2'-O-methylcytosine

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n represents a nucleotide comprising a nitrogenous base 
selected from the group consisting of guanine, 
5-methylguanine, or 2'-O-methylguanine

<400>  2
gtnncccctt ctcccnncag c                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  represents 5-methyl-2'-deoxycytidine (5-Me-dC)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  represents 5-methyl-2'-deoxycytidine (5-Me-dC)

<400>  3
gtngcccctt ctcccngcag c                                                 21


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide

<400>  4
gtcgcccctt ctccccgcag                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  represents 5-methyl-2'-deoxycytidine (5-Me-dC)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  represents 5-methyl-2'-deoxycytidine (5-Me-dC)

<400>  5
gtngcccctt ctcccngcag                                                   20


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide

<400>  6
gtttggtcct gaacatgc                                                     18


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide

<400>  7
gtttggtcct gaacat                                                       16


<210>  8
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide

<400>  8
gtttggtcct gaacatg                                                      17


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide

<400>  9
agcaccgagt gcgtgagc                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide

<400>  10
cgaacatgac ctccgcac                                                     18


<210>  11
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide

<400>  11
gatcgtttgg tcctgaa                                                      17


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-SMAD7 oligonucleotide or a chemically modified anti-SMAD7 
       oligonucleotide

<400>  12
atcgtttggt cctgaac                                                      17


