                         SEQUENCE LISTING

<110>  IDP DISCOVERY PHARMA, S.L.
 
<120>  Anticancer peptides

<130>  P4098PC00

<150>  EP17382533.2
<151>  2017-08-02

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  1

Arg Lys Arg Arg Asn Asp Leu Arg Ser Arg Phe Leu Ala Leu Arg Asp 
1               5                   10                  15      


Gln 
    


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 11, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 7, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  2

Arg Lys Arg Xaa Asn Asp Leu Arg Ser Arg Xaa Leu Ala Leu Arg Asp 
1               5                   10                  15      


Gln 
    


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 15, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 8, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  3

Arg Lys Arg Arg Asn Asp Leu Xaa Ser Arg Phe Leu Ala Leu Xaa Asp 
1               5                   10                  15      


Gln 
    


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 17, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 10, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  4

Arg Lys Arg Arg Asn Asp Leu Arg Ser Xaa Phe Leu Ala Leu Arg Asp 
1               5                   10                  15      


Xaa 
    


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 13, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 6, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  5

Ala Pro Lys Val Val Xaa Leu Ser Lys Ala Leu Glu Xaa Leu Gln Ala 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 15, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 8, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  6

Ala Pro Lys Val Val Ile Leu Xaa Lys Ala Leu Glu Tyr Leu Xaa Ala 
1               5                   10                  15      


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 15, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 8, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  7

Arg Arg Asn Asp Leu Arg Ser Xaa Phe Leu Ala Leu Arg Asp Xaa Val 
1               5                   10                  15      


Pro 
    


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  8

Arg Arg Arg Arg Arg Arg Arg Ser Lys Ala Pro Lys Val Val Ile Leu 
1               5                   10                  15      


Ser Lys Ala Leu Glu Tyr Leu Gln Ala 
            20                  25  


<210>  9
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  9

Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Ser 
1               5                   10                  15      


Lys Ala Pro Lys Val Val Ile Leu Ser Lys Ala Leu Glu Tyr Leu Gln 
            20                  25                  30          


Ala 
    


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 9, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 1, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  10

Xaa Lys Ala Pro Lys Val Val Xaa Leu Ser Lys Ala Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 9, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 2, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  11

Ser Xaa Ala Pro Lys Val Val Ile Xaa Ser Lys Ala Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 10, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 3, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  12

Ser Lys Xaa Pro Lys Val Val Ile Leu Xaa Lys Ala Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 11, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 4, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  13

Ser Lys Ala Xaa Lys Val Val Ile Leu Ser Xaa Ala Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 12, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 5, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  14

Ser Lys Ala Pro Xaa Val Val Ile Leu Ser Lys Xaa Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 13, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  the amino acid is of formula (III), being R19 a -CH3 radical; the
       alpha carbon of this amino acid being connected to the alpha  
       carbon of amino acid at position 6, by the linker 
       -(CH2)6-CH=CH-(CH2)3-

<400>  15

Ser Lys Ala Pro Lys Xaa Val Ile Leu Ser Lys Ala Xaa Glu Tyr Leu 
1               5                   10                  15      


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  16

Ser Lys Ala Pro Lys Val Val Ile Leu Ser Lys Ala Leu Glu Tyr Leu 
1               5                   10                  15      


Gln Ala 
        


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 15, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 8, by the linker "L" as defined 
       in claim 1

<400>  17

Ser Lys Ala Pro Lys Val Val Xaa Leu Ser Lys Ala Leu Glu Xaa Leu 
1               5                   10                  15      


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 17, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 10, by the linker "L" as defined
       in claim 1

<400>  18

Ser Lys Ala Pro Lys Val Val Ile Leu Xaa Lys Ala Leu Glu Tyr Leu 
1               5                   10                  15      


Xaa 
    


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 8, by the linker "L" as defined 
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 1, by the linker "L" as defined 
       in claim 1

<400>  19

Xaa Lys Ala Pro Lys Val Val Xaa Leu Ser Lys Ala Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 9, by the linker "L" as defined 
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 2, by the linker "L" as defined 
       in claim 1

<400>  20

Ser Xaa Ala Pro Lys Val Val Ile Xaa Ser Lys Ala Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 10, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 3, by the linker "L" as defined 
       in claim 1

<400>  21

Ser Lys Xaa Pro Lys Val Val Ile Leu Xaa Lys Ala Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 11, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 4, by the linker "L" as defined 
       in claim 1

<400>  22

Ser Lys Ala Xaa Lys Val Val Ile Leu Ser Xaa Ala Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 12, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 5, by the linker "L" as defined 
       in claim 1

<400>  23

Ser Lys Ala Pro Xaa Val Val Ile Leu Ser Lys Xaa Leu Glu Tyr Leu 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 13, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 6, by the linker "L" as defined 
       in claim 1

<400>  24

Ser Lys Ala Pro Lys Xaa Val Ile Leu Ser Lys Ala Xaa Glu Tyr Leu 
1               5                   10                  15      


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 11, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 4, by the linker "L" as defined 
       in claim 1

<400>  25

Arg Lys Arg Xaa Asn Asp Leu Arg Ser Arg Xaa Leu Ala Leu Arg Asp 
1               5                   10                  15      


Gln 
    


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 15, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 8, by the linker "L" as defined 
       in claim 1

<400>  26

Arg Lys Arg Arg Asn Asp Leu Xaa Ser Arg Phe Leu Ala Leu Xaa Asp 
1               5                   10                  15      


Gln 
    


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 17, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 10, by the linker "L" as defined
       in claim 1

<400>  27

Arg Lys Arg Arg Asn Asp Leu Arg Ser Xaa Phe Leu Ala Leu Arg Asp 
1               5                   10                  15      


Xaa 
    


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 15, by the linker "L" as defined
       in claim 1

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (III) as defined in claim 1; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 8, by the linker "L" as defined 
       in claim 1

<400>  28

Arg Arg Asn Asp Leu Arg Ser Xaa Phe Leu Ala Leu Arg Asp Xaa Val 
1               5                   10                  15      


Pro 
    


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  29

Arg Arg Arg Arg Arg Arg Arg Arg Lys Arg Arg Asn Asp Leu Arg Ser 
1               5                   10                  15      


Arg Phe Leu Ala Leu Arg Asp Gln 
            20                  


