                         SEQUENCE LISTING

<110>  Reflection Biotechnologies Limited
 
<120>  CELLULAR MODELS OF AND THERAPIES FOR OCULAR DISEASES

<130>  43219-0003WO1

<140>  PCT/IB2018/055755
<141>  2018-07-31

<150>  US 62/539,473
<151>  2017-07-31

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  1578
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated coding sequence

<400>  1
atggcggggc tctggctggg gctcgtgtgg cagaagctgc tgctgtgggg cgcggcgagt       60

gccctttccc tggccggcgc cagtctggtc ctgagcctgc tgcagagggt ggcgagctac      120

gcgcggaaat ggcagcagat gcggcccatc cccacggtgg cccgcgccta cccactggtg      180

ggccacgcgc tgctgatgaa gccggacggg cgagaatttt ttcagcagat cattgagtac      240

acagaggaat accgccacat gccgctgctg aagctctggg tcgggccagt gcccatggtg      300

gccctttata atgcagaaaa tgtggaggta attttaacta gttcaaagca aattgacaaa      360

tcctctatgt acaagttttt agaaccatgg cttggcctag gacttcttac aagtactgga      420

aacaaatggc gctccaggag aaagatgtta acacccactt tccattttac cattctggaa      480

gatttcttag atatcatgaa tgaacaagca aatatattgg ttaagaaact tgaaaaacac      540

attaaccaag aagcatttaa ctgctttttt tacatcactc tttgtgcctt agatatcatc      600

tgtgaaacag ctatggggaa gaatattggt gctcaaagta atgatgattc cgagtatgtc      660

cgtgcagttt atagaatgag tgagatgata tttcgaagaa taaagatgcc ctggctttgg      720

cttgatctct ggtaccttat gtttaaagaa ggatgggaac acaaaaagag ccttcagatc      780

ctacatactt ttaccaacag tgtcatcgct gaacgggcca atgaaatgaa cgccaatgaa      840

gactgtagag gtgatggcag gggctctgcc ccctccaaaa ataaacgcag ggcctttctt      900

gacttgcttt taagtgtgac tgatgacgaa gggaacaggc taagtcatga agatattcga      960

gaagaagttg acaccttcat gtttgagggg cacgatacaa ctgcagctgc aataaactgg     1020

tccttatacc tgttgggttc taacccagaa gtccagaaaa aagtggatca tgaattggat     1080

gacgtgtttg ggaagtctga ccgtcccgct acagtagaag acctgaagaa acttcggtat     1140

ctggaatgtg ttattaagga gacccttcgc ctttttcctt ctgttccttt atttgcccgt     1200

agtgttagtg aagattgtga agtggcaggt tacagagttc taaaaggcac tgaagccgtc     1260

atcattccct atgcattgca cagagatccg agatacttcc ccaaccccga ggagttccag     1320

cctgagcggt tcttccccga gaatgcacaa gggcgccatc catatgccta cgtgcccttc     1380

tctgctggcc ccaggaactg tataggtcaa aagtttgctg tgatggaaga aaagaccatt     1440

ctttcgtgca tcctgaggca cttttggata gaatccaacc agaaaagaga agagcttggt     1500

ctagaaggac agttgattct tcgtccaagt aatggcatct ggatcaagtt gaagaggaga     1560

aatgcagatg aacgctaa                                                   1578


<210>  2
<211>  1578
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated coding sequence

<400>  2
atggctggac tgtggctggg actggtgtgg cagaaactgc tgctgtgggg ggccgcttcc       60

gcactgtcac tggctggggc ttcactggtg ctgagcctgc tgcagagggt ggcctcctac      120

gccagaaagt ggcagcagat gaggcccatc cctaccgtgg ccagagccta tccactggtg      180

ggacacgcac tgctgatgaa gcctgacggc agagagttct ttcagcagat catcgagtac      240

acagaggagt ataggcacat gccactgctg aagctgtggg tgggacccgt gcctatggtg      300

gccctgtaca acgccgagaa tgtggaagtg atcctgacca gcagcaagca gatcgataag      360

tctagcatgt ataagttcct ggagccttgg ctgggcctgg gcctgctgac ctctacaggc      420

aacaagtgga ggagccggag aaagatgctg accccaacat tccactttac aatcctggag      480

gacttcctgg acatcatgaa cgagcaggcc aatatcctgg tgaagaagct ggagaagcac      540

atcaaccagg aggcctttaa ttgcttcttt tacatcaccc tgtgcgccct ggacatcatc      600

tgtgagacag ctatgggcaa gaacatcggc gcccagtcta atgacgatag cgagtacgtg      660

cgggccgtgt atagaatgag cgagatgatc tttaggcgca tcaagatgcc ctggctgtgg      720

ctggatctgt ggtatctgat gttcaaggag ggctgggagc acaagaagtc cctgcagatc      780

ctgcacacct ttacaaactc tgtgatcgcc gagagagcca atgagatgaa cgccaatgag      840

gactgtaggg gcgatggaag gggcagcgcc ccttccaaga acaagcggag agccttcctg      900

gacctgctgc tgagcgtgac cgacgatgag ggcaatcgcc tgtcccacga ggacatccgg      960

gaggaggtgg atacattcat gtttgaggga cacgacacca cagccgccgc catcaactgg     1020

tccctgtacc tgctgggctc taatccagag gtgcagaaga aggtggatca cgagctggac     1080

gacgtgttcg gcaagtccga caggccagca accgtggagg atctgaagaa gctgagatac     1140

ctggagtgcg tgatcaagga gacactgcgc ctgttcccct ctgtgcctct gtttgcccgg     1200

tccgtgtctg aggactgtga ggtggccggc tatcgcgtgc tgaagggcac cgaggccgtg     1260

atcatccctt acgccctgca ccgggacccc aggtatttcc ctaacccaga ggagtttcag     1320

ccagagagat tctttcccga gaatgcccag ggcaggcacc cttacgccta tgtgccattc     1380

tccgccggac caaggaactg catcggacag aagtttgccg tgatggagga gaaaaccatc     1440

ctgtcttgta tcctgagaca cttctggatc gagagcaatc agaagaggga ggagctgggc     1500

ctggagggac agctgatcct gcggccaagc aacggcatct ggatcaaact gaaaagaagg     1560

aacgctgacg agaggtaa                                                   1578


<210>  3
<211>  1578
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated coding sequence

<400>  3
atggcggggc tctggctggg gctcgtgtgg cagaagctgc tgctgtgggg cgcggcgagt       60

gccctttccc tggccggcgc cagtctggtc ctgagcctgc tgcagagggt ggcgagctac      120

gcgcggaaat ggcagcagat gcggcccatc cccacggtgg cccgcgccta cccactggtg      180

ggccacgcgc tgctgatgaa gccggacggg cgagaatttt ttcagcagat cattgagtac      240

acagaggaat accgccacat gccgctgctg aagctctggg tcgggccagt gcccatggtg      300

gccctttata atgcagaaaa tgtggaggta attttaacta gttcaaagca aattgacaaa      360

tcctctatgt acaagttttt agaaccatgg cttggcctag gacttcttac aagtactgga      420

aacaaatggc gctccaggag aaagatgtta acacccactt tccattttac cattctggaa      480

gatttcttag atatcatgaa tgaacaagca aatatattgg ttaagaaact tgaaaaacac      540

attaaccaag aagcatttaa ctgctttttt tacatcactc tttgtgcctt agatatcatc      600

tgtgaaacag ctatggggaa gaatattggt gctcaaagta atgatgattc cgagtatgtc      660

cgtgcagttt atagaatgag tgagatgata tttcgaagaa taaagatgcc ctggctttgg      720

cttgatctct ggtaccttat gtttaaagaa ggatgggaac acaaaaagag ccttaagatc      780

ctacatactt ttaccaacag tgtcatcgcg gaacgggcca atgaaatgaa cgccaatgaa      840

gactgtagag gtgatggcag gggctctgcc ccctccaaaa ataaacgcag ggcctttctt      900

gacttgcttt taagtgtgac tgatgacgaa gggaacaggc taagtcatga agatattcga      960

gaagaagttg acaccttcat gtttgagggg cacgatacaa ctgcagctgc aataaactgg     1020

tccttatacc tgttgggttc taacccagaa gtccagaaaa aagtggatca tgaattggat     1080

gacgtgtttg ggaagtctga ccgtcccgct acagtagaag acctgaagaa acttcggtat     1140

ctggaatgtg ttattaagga gacccttcgc ctttttcctt ctgttccttt atttgcccgt     1200

agtgttagtg aagattgtga agtggcaggt tacagagttc taaaaggcac tgaagccgtc     1260

atcattccct atgcattgca cagagatccg agatacttcc ccaaccccga ggagttccag     1320

cctgagcggt tcttccccga gaatgcacaa gggcgccatc catatgccta cgtgcccttc     1380

tctgctggcc ccaggaactg tataggtcaa aagtttgctg tgatggaaga aaagaccatt     1440

ctttcgtgca tcctgaggca cttttggata gaatccaacc agaaaagaga agagcttggt     1500

ctagaaggac agttgattct tcgtccaagt aatggcatct ggatcaagtt gaagaggaga     1560

aatgcagatg aacgctaa                                                   1578


<210>  4
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Leu Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Ile Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Gln Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Lys Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Ser Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Arg 
        515                 520                 525 


<210>  5
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Leu Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Ile Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Lys Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Lys Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Ser Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Arg 
        515                 520                 525 


<210>  6
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg Pro Ile Pro 
1               5                   10                  15      


Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu Leu Met Lys 
            20                  25                  30          


Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr Thr Glu Glu 
        35                  40                  45              


Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro Val Pro Met 
    50                  55                  60                  


Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu Thr Ser Ser 
65                  70                  75                  80  


Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu Pro Trp Leu 
                85                  90                  95      


Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg Ser Arg Arg 
            100                 105                 110         


Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu Asp Phe Leu 
        115                 120                 125             


Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys Leu Glu Lys 
    130                 135                 140                 


His Ile Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile Thr Leu Cys 
145                 150                 155                 160 


Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn Ile Gly Ala 
                165                 170                 175     


Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr Arg Met Ser 
            180                 185                 190         


Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp Leu Asp Leu 
        195                 200                 205             


Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys Ser Leu Gln 
    210                 215                 220                 


Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg Ala Asn Glu 
225                 230                 235                 240 


Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly Ser Ala Pro 
                245                 250                 255     


Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu Ser Val Thr 
            260                 265                 270         


Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg Glu Glu Val 
        275                 280                 285             


Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala Ala Ile Asn 
    290                 295                 300                 


Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln Lys Lys Val 
305                 310                 315                 320 


Asp His Glu Leu Asp Asp Val Phe Gly Lys Ser Asp Arg Pro Ala Thr 
                325                 330                 335     


Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val Ile Lys Glu 
            340                 345                 350         


Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg Ser Val Ser 
        355                 360                 365             


Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly Thr Glu Ala 
    370                 375                 380                 


Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr Phe Pro Asn 
385                 390                 395                 400 


Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn Ala Gln Gly 
                405                 410                 415     


Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro Arg Asn Cys 
            420                 425                 430         


Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile Leu Ser Cys 
        435                 440                 445             


Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg Glu Glu Leu 
    450                 455                 460                 


Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Ser Asn Gly Ile Trp Ile 
465                 470                 475                 480 


Lys Leu Lys Arg Arg Asn Ala Asp Glu Arg 
                485                 490 


<210>  7
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Pro Gly Leu Leu Leu Leu Gly Ser Ala Val Leu Leu Ala Phe 
1               5                   10                  15      


Gly Leu Cys Cys Thr Phe Val His Arg Ala Arg Ser Arg Tyr Glu His 
            20                  25                  30          


Ile Pro Gly Pro Pro Arg Pro Ser Phe Leu Leu Gly His Leu Pro Cys 
        35                  40                  45              


Phe Trp Lys Lys Asp Glu Val Gly Gly Arg Val Leu Gln Asp Val Phe 
    50                  55                  60                  


Leu Asp Trp Ala Lys Lys Tyr Gly Pro Val Val Arg Val Asn Val Phe 
65                  70                  75                  80  


His Lys Thr Ser Val Ile Val Thr Ser Pro Glu Ser Val Lys Lys Phe 
                85                  90                  95      


Leu Met Ser Thr Lys Tyr Asn Lys Asp Ser Lys Met Tyr Arg Ala Leu 
            100                 105                 110         


Gln Thr Val Phe Gly Glu Arg Leu Phe Gly Gln Gly Leu Val Ser Glu 
        115                 120                 125             


Cys Asn Tyr Glu Arg Trp His Lys Gln Arg Arg Val Ile Asp Leu Ala 
    130                 135                 140                 


Phe Ser Arg Ser Ser Leu Val Ser Leu Met Glu Thr Phe Asn Glu Lys 
145                 150                 155                 160 


Ala Glu Gln Leu Val Glu Ile Leu Glu Ala Lys Ala Asp Gly Gln Thr 
                165                 170                 175     


Pro Val Ser Met Gln Asp Met Leu Thr Tyr Thr Ala Met Asp Ile Leu 
            180                 185                 190         


Ala Lys Ala Ala Phe Gly Met Glu Thr Ser Met Leu Leu Gly Ala Gln 
        195                 200                 205             


Lys Pro Leu Ser Gln Ala Val Lys Leu Met Leu Glu Gly Ile Thr Ala 
    210                 215                 220                 


Ser Arg Asn Thr Leu Ala Lys Phe Leu Pro Gly Lys Arg Lys Gln Leu 
225                 230                 235                 240 


Arg Glu Val Arg Glu Ser Ile Arg Phe Leu Arg Gln Val Gly Arg Asp 
                245                 250                 255     


Trp Val Gln Arg Arg Arg Glu Ala Leu Lys Arg Gly Glu Glu Val Pro 
            260                 265                 270         


Ala Asp Ile Leu Thr Gln Ile Leu Lys Ala Glu Glu Gly Ala Gln Asp 
        275                 280                 285             


Asp Glu Gly Leu Leu Asp Asn Phe Val Thr Phe Phe Ile Ala Gly His 
    290                 295                 300                 


Glu Thr Ser Ala Asn His Leu Ala Phe Thr Val Met Glu Leu Ser Arg 
305                 310                 315                 320 


Gln Pro Glu Ile Val Ala Arg Leu Gln Ala Glu Val Asp Glu Val Ile 
                325                 330                 335     


Gly Ser Lys Arg Tyr Leu Asp Phe Glu Asp Leu Gly Arg Leu Gln Tyr 
            340                 345                 350         


Leu Ser Gln Val Leu Lys Glu Ser Leu Arg Leu Tyr Pro Pro Ala Trp 
        355                 360                 365             


Gly Thr Phe Arg Leu Leu Glu Glu Glu Thr Leu Ile Asp Gly Val Arg 
    370                 375                 380                 


Val Pro Gly Asn Thr Pro Leu Leu Phe Ser Thr Tyr Val Met Gly Arg 
385                 390                 395                 400 


Met Asp Thr Tyr Phe Glu Asp Pro Leu Thr Phe Asn Pro Asp Arg Phe 
                405                 410                 415     


Gly Pro Gly Ala Pro Lys Pro Arg Phe Thr Tyr Phe Pro Phe Ser Leu 
            420                 425                 430         


Gly His Arg Ser Cys Ile Gly Gln Gln Phe Ala Gln Met Glu Val Lys 
        435                 440                 445             


Val Val Met Ala Lys Leu Leu Gln Arg Leu Glu Phe Arg Leu Val Pro 
    450                 455                 460                 


Gly Gln Arg Phe Gly Leu Gln Glu Gln Ala Thr Leu Lys Pro Leu Asp 
465                 470                 475                 480 


Pro Val Leu Cys Thr Leu Arg Pro Arg Gly Trp Gln Pro Ala Pro Pro 
                485                 490                 495     


Pro Pro Pro Cys 
            500 


<210>  8
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Val Ser Val Leu Ser Pro Ser Arg Leu Leu Gly Asp Val Ser 
1               5                   10                  15      


Gly Ile Leu Gln Ala Ala Ser Leu Leu Ile Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Lys Ala Val Gln Leu Tyr Leu His Arg Gln Trp Leu Leu Lys Ala Leu 
        35                  40                  45              


Gln Gln Phe Pro Cys Pro Pro Ser His Trp Leu Phe Gly His Ile Gln 
    50                  55                  60                  


Glu Leu Gln Gln Asp Gln Glu Leu Gln Arg Ile Gln Lys Trp Val Glu 
65                  70                  75                  80  


Thr Phe Pro Ser Ala Cys Pro His Trp Leu Trp Gly Gly Lys Val Arg 
                85                  90                  95      


Val Gln Leu Tyr Asp Pro Asp Tyr Met Lys Val Ile Leu Gly Arg Ser 
            100                 105                 110         


Asp Pro Lys Ser His Gly Ser Tyr Arg Phe Leu Ala Pro Trp Ile Gly 
        115                 120                 125             


Tyr Gly Leu Leu Leu Leu Asn Gly Gln Thr Trp Phe Gln His Arg Arg 
    130                 135                 140                 


Met Leu Thr Pro Ala Phe His Tyr Asp Ile Leu Lys Pro Tyr Val Gly 
145                 150                 155                 160 


Leu Met Ala Asp Ser Val Arg Val Met Leu Asp Lys Trp Glu Glu Leu 
                165                 170                 175     


Leu Gly Gln Asp Ser Pro Leu Glu Val Phe Gln His Val Ser Leu Met 
            180                 185                 190         


Thr Leu Asp Thr Ile Met Lys Cys Ala Phe Ser His Gln Gly Ser Ile 
        195                 200                 205             


Gln Val Asp Arg Asn Ser Gln Ser Tyr Ile Gln Ala Ile Ser Asp Leu 
    210                 215                 220                 


Asn Asn Leu Val Phe Ser Arg Val Arg Asn Ala Phe His Gln Asn Asp 
225                 230                 235                 240 


Thr Ile Tyr Ser Leu Thr Ser Ala Gly Arg Trp Thr His Arg Ala Cys 
                245                 250                 255     


Gln Leu Ala His Gln His Thr Asp Gln Val Ile Gln Leu Arg Lys Ala 
            260                 265                 270         


Gln Leu Gln Lys Glu Gly Glu Leu Glu Lys Ile Lys Arg Lys Arg His 
        275                 280                 285             


Leu Asp Phe Leu Asp Ile Leu Leu Leu Ala Lys Met Glu Asn Gly Ser 
    290                 295                 300                 


Ile Leu Ser Asp Lys Asp Leu Arg Ala Glu Val Asp Thr Phe Met Phe 
305                 310                 315                 320 


Glu Gly His Asp Thr Thr Ala Ser Gly Ile Ser Trp Ile Leu Tyr Ala 
                325                 330                 335     


Leu Ala Thr His Pro Lys His Gln Glu Arg Cys Arg Glu Glu Ile His 
            340                 345                 350         


Ser Leu Leu Gly Asp Gly Ala Ser Ile Thr Trp Asn His Leu Asp Gln 
        355                 360                 365             


Met Pro Tyr Thr Thr Met Cys Ile Lys Glu Ala Leu Arg Leu Tyr Pro 
    370                 375                 380                 


Pro Val Pro Gly Ile Gly Arg Glu Leu Ser Thr Pro Val Thr Phe Pro 
385                 390                 395                 400 


Asp Gly Arg Ser Leu Pro Lys Gly Ile Met Val Leu Leu Ser Ile Tyr 
                405                 410                 415     


Gly Leu His His Asn Pro Lys Val Trp Pro Asn Pro Glu Val Phe Asp 
            420                 425                 430         


Pro Phe Arg Phe Ala Pro Gly Ser Ala Gln His Ser His Ala Phe Leu 
        435                 440                 445             


Pro Phe Ser Gly Gly Ser Arg Asn Cys Ile Gly Lys Gln Phe Ala Met 
    450                 455                 460                 


Asn Glu Leu Lys Val Ala Thr Ala Leu Thr Leu Leu Arg Phe Glu Leu 
465                 470                 475                 480 


Leu Pro Asp Pro Thr Arg Ile Pro Ile Pro Ile Ala Arg Leu Val Leu 
                485                 490                 495     


Lys Ser Lys Asn Gly Ile His Leu Arg Leu Arg Arg Leu Pro Asn Pro 
            500                 505                 510         


Cys Glu Asp Lys Asp Gln Leu 
        515                 


<210>  9
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Val Ser Val Leu Ser Pro Ser Arg Arg Leu Gly Gly Val Ser 
1               5                   10                  15      


Gly Ile Leu Gln Val Thr Ser Leu Leu Ile Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Lys Ala Ala Gln Leu Tyr Leu His Arg Gln Trp Leu Leu Lys Ala Leu 
        35                  40                  45              


Gln Gln Phe Pro Cys Pro Pro Ser His Trp Leu Phe Gly His Ile Gln 
    50                  55                  60                  


Glu Phe Gln His Asp Gln Glu Leu Gln Arg Ile Gln Glu Arg Val Lys 
65                  70                  75                  80  


Thr Phe Pro Ser Ala Cys Pro Tyr Trp Ile Trp Gly Gly Lys Val Arg 
                85                  90                  95      


Val Gln Leu Tyr Asp Pro Asp Tyr Met Lys Val Ile Leu Gly Arg Ser 
            100                 105                 110         


Asp Pro Lys Ser His Gly Ser Tyr Lys Phe Leu Ala Pro Arg Ile Gly 
        115                 120                 125             


Tyr Gly Leu Leu Leu Leu Asn Gly Gln Thr Trp Phe Gln His Arg Arg 
    130                 135                 140                 


Met Leu Thr Pro Ala Phe His Asn Asp Ile Leu Lys Pro Tyr Val Gly 
145                 150                 155                 160 


Leu Met Ala Asp Ser Val Arg Val Met Leu Asp Lys Trp Glu Glu Leu 
                165                 170                 175     


Leu Gly Gln Asp Ser Pro Leu Glu Val Phe Gln His Val Ser Leu Met 
            180                 185                 190         


Thr Leu Asp Thr Ile Met Lys Ser Ala Phe Ser His Gln Gly Ser Ile 
        195                 200                 205             


Gln Val Asp Arg Asn Ser Gln Ser Tyr Ile Gln Ala Ile Ser Asp Leu 
    210                 215                 220                 


Asn Ser Leu Val Phe Cys Cys Met Arg Asn Ala Phe His Glu Asn Asp 
225                 230                 235                 240 


Thr Ile Tyr Ser Leu Thr Ser Ala Gly Arg Trp Thr His Arg Ala Cys 
                245                 250                 255     


Gln Leu Ala His Gln His Thr Asp Gln Val Ile Gln Leu Arg Lys Ala 
            260                 265                 270         


Gln Leu Gln Lys Glu Gly Glu Leu Glu Lys Ile Lys Arg Lys Arg His 
        275                 280                 285             


Leu Asp Phe Leu Asp Ile Leu Leu Leu Ala Lys Met Glu Asn Gly Ser 
    290                 295                 300                 


Ile Leu Ser Asp Lys Asp Leu Arg Ala Glu Val Asp Thr Phe Met Phe 
305                 310                 315                 320 


Glu Gly His Asp Thr Thr Ala Ser Gly Ile Ser Trp Ile Leu Tyr Ala 
                325                 330                 335     


Leu Ala Thr His Pro Lys His Gln Glu Arg Cys Arg Glu Glu Ile His 
            340                 345                 350         


Gly Leu Leu Gly Asp Gly Ala Ser Ile Thr Trp Asn His Leu Asp Gln 
        355                 360                 365             


Met Pro Tyr Thr Thr Met Cys Ile Lys Glu Ala Leu Arg Leu Tyr Pro 
    370                 375                 380                 


Pro Val Pro Gly Ile Gly Arg Glu Leu Ser Thr Pro Val Thr Phe Pro 
385                 390                 395                 400 


Asp Gly Arg Ser Leu Pro Lys Gly Ile Met Val Leu Leu Ser Ile Tyr 
                405                 410                 415     


Gly Leu His His Asn Pro Lys Val Trp Pro Asn Leu Glu Val Phe Asp 
            420                 425                 430         


Pro Ser Arg Phe Ala Pro Gly Ser Ala Gln His Ser His Ala Phe Leu 
        435                 440                 445             


Pro Phe Ser Gly Gly Ser Arg Asn Cys Ile Gly Lys Gln Phe Ala Met 
    450                 455                 460                 


Asn Gln Leu Lys Val Ala Arg Ala Leu Thr Leu Leu Arg Phe Glu Leu 
465                 470                 475                 480 


Leu Pro Asp Pro Thr Arg Ile Pro Ile Pro Met Ala Arg Leu Val Leu 
                485                 490                 495     


Lys Ser Lys Asn Gly Ile His Leu Arg Leu Arg Arg Leu Pro Asn Pro 
            500                 505                 510         


Cys Glu Asp Lys Asp Gln Leu 
        515                 


<210>  10
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Pro Ser Phe Leu Ser Leu Ser Phe Ser Ser Leu Gly Leu Trp 
1               5                   10                  15      


Ala Ser Gly Leu Ile Leu Val Leu Gly Phe Leu Lys Leu Ile His Leu 
            20                  25                  30          


Leu Leu Arg Arg Gln Thr Leu Ala Lys Ala Met Asp Lys Phe Pro Gly 
        35                  40                  45              


Pro Pro Thr His Trp Leu Phe Gly His Ala Leu Glu Ile Gln Glu Thr 
    50                  55                  60                  


Gly Ser Leu Asp Lys Val Val Ser Trp Ala His Gln Phe Pro Tyr Ala 
65                  70                  75                  80  


His Pro Leu Trp Phe Gly Gln Phe Ile Gly Phe Leu Asn Ile Tyr Glu 
                85                  90                  95      


Pro Asp Tyr Ala Lys Ala Val Tyr Ser Arg Gly Asp Pro Lys Ala Pro 
            100                 105                 110         


Asp Val Tyr Asp Phe Phe Leu Gln Trp Ile Gly Arg Gly Leu Leu Val 
        115                 120                 125             


Leu Glu Gly Pro Lys Trp Leu Gln His Arg Lys Leu Leu Thr Pro Gly 
    130                 135                 140                 


Phe His Tyr Asp Val Leu Lys Pro Tyr Val Ala Val Phe Thr Glu Ser 
145                 150                 155                 160 


Thr Arg Ile Met Leu Asp Lys Trp Glu Glu Lys Ala Arg Glu Gly Lys 
                165                 170                 175     


Ser Phe Asp Ile Phe Cys Asp Val Gly His Met Ala Leu Asn Thr Leu 
            180                 185                 190         


Met Lys Cys Thr Phe Gly Arg Gly Asp Thr Gly Leu Gly His Arg Asp 
        195                 200                 205             


Ser Ser Tyr Tyr Leu Ala Val Ser Asp Leu Thr Leu Leu Met Gln Gln 
    210                 215                 220                 


Arg Leu Val Ser Phe Gln Tyr His Asn Asp Phe Ile Tyr Trp Leu Thr 
225                 230                 235                 240 


Pro His Gly Arg Arg Phe Leu Arg Ala Cys Gln Val Ala His Asp His 
                245                 250                 255     


Thr Asp Gln Val Ile Arg Glu Arg Lys Ala Ala Leu Gln Asp Glu Lys 
            260                 265                 270         


Val Arg Lys Lys Ile Gln Asn Arg Arg His Leu Asp Phe Leu Asp Ile 
        275                 280                 285             


Leu Leu Gly Ala Arg Asp Glu Asp Asp Ile Lys Leu Ser Asp Ala Asp 
    290                 295                 300                 


Leu Arg Ala Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr 
305                 310                 315                 320 


Thr Ser Gly Ile Ser Trp Phe Leu Tyr Cys Met Ala Leu Tyr Pro Glu 
                325                 330                 335     


His Gln His Arg Cys Arg Glu Glu Val Arg Glu Ile Leu Gly Asp Gln 
            340                 345                 350         


Asp Phe Phe Gln Trp Asp Asp Leu Gly Lys Met Thr Tyr Leu Thr Met 
        355                 360                 365             


Cys Ile Lys Glu Ser Phe Arg Leu Tyr Pro Pro Val Pro Gln Val Tyr 
    370                 375                 380                 


Arg Gln Leu Ser Lys Pro Val Thr Phe Val Asp Gly Arg Ser Leu Pro 
385                 390                 395                 400 


Ala Gly Ser Leu Ile Ser Met His Ile Tyr Ala Leu His Arg Asn Ser 
                405                 410                 415     


Ala Val Trp Pro Asp Pro Glu Val Phe Asp Ser Leu Arg Phe Ser Thr 
            420                 425                 430         


Glu Asn Ala Ser Lys Arg His Pro Phe Ala Phe Met Pro Phe Ser Ala 
        435                 440                 445             


Gly Pro Arg Asn Cys Ile Gly Gln Gln Phe Ala Met Ser Glu Met Lys 
    450                 455                 460                 


Val Val Thr Ala Met Cys Leu Leu Arg Phe Glu Phe Ser Leu Asp Pro 
465                 470                 475                 480 


Ser Arg Leu Pro Ile Lys Met Pro Gln Leu Val Leu Arg Ser Lys Asn 
                485                 490                 495     


Gly Phe His Leu His Leu Lys Pro Leu Gly Pro Gly Ser Gly Lys 
            500                 505                 510     


<210>  11
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Gln Leu Ser Leu Ser Trp Leu Gly Leu Trp Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


His Val Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Arg Arg Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Met Val Asn Pro Thr Glu Glu Gly Met Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Lys Val Trp Met Gly Pro Ile Ser 
                85                  90                  95      


Pro Leu Leu Ser Leu Cys His Pro Asp Ile Ile Arg Ser Val Ile Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Lys Phe Phe Tyr Ser Phe Leu 
        115                 120                 125             


Glu Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Cys Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Ser Lys Arg His His Glu Ile Leu 
225                 230                 235                 240 


Leu His Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala His Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Met Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


His Val Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Thr Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  12
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Gln Leu Ser Leu Ser Ser Leu Gly Leu Trp Pro Met Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Cys Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Ile His Ser Ser Glu Glu Gly Leu Leu Tyr Thr Gln Ser Leu 
65                  70                  75                  80  


Ala Cys Thr Phe Gly Asp Met Cys Cys Trp Trp Val Gly Pro Trp His 
                85                  90                  95      


Ala Ile Val Arg Ile Phe His Pro Thr Tyr Ile Lys Pro Val Leu Phe 
            100                 105                 110         


Ala Pro Ala Ala Ile Val Pro Lys Asp Lys Val Phe Tyr Ser Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Glu Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Thr Lys Arg His Gln Gln Ile Leu 
225                 230                 235                 240 


Leu Tyr Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Ala Val Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Lys 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Gly Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  13
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Leu Leu Ser Leu Ser Trp Leu Gly Leu Arg Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Val Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr His Asn Gly Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Arg Lys Gln Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Leu Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Val Arg Trp Leu Gly Pro Ile Thr 
                85                  90                  95      


Pro Ile Ile Asn Leu Cys His Pro Asp Ile Val Arg Ser Val Ile Asn 
            100                 105                 110         


Thr Ser Asp Ala Ile Thr Asp Lys Asp Ile Val Phe Tyr Lys Thr Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Val Gly Asp Lys Trp 
    130                 135                 140                 


Arg His His Arg Arg Leu Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Ile Lys Ile Phe Ser Lys Ser Ala Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Met Glu Gly Ser Thr Cys Leu Asp Val Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Thr Ala 
    210                 215                 220                 


Ile Met Glu Leu Ser Ala Leu Val Val Lys Arg Asn Asn Gln Phe Phe 
225                 230                 235                 240 


Arg Tyr Lys Asp Phe Leu Tyr Phe Leu Thr Pro Cys Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Thr Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Glu Asp Lys Asn Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Leu Lys Glu Ser Leu Arg Leu His Pro Pro Ile Pro Thr Phe Ala Arg 
385                 390                 395                 400 


Gly Cys Thr Gln Asp Val Val Leu Pro Asp Ser Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Asn Val Cys Asn Ile Asn Ile Phe Ala Ile His His Asn Pro Ser 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ala Gln Lys Arg Ser Pro Met Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Lys Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Ile Leu Pro Asp His Arg 
                485                 490                 495     


Glu Pro Arg Arg Thr Pro Glu Ile Val Leu Arg Ala Glu Asp Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly 
        515                 520 


<210>  14
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Gln Leu Ser Leu Ser Trp Leu Gly Leu Gly Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Val Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Gln Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Met Lys Thr Leu Thr Gln Leu 
65                  70                  75                  80  


Val Thr Thr Tyr Pro Gln Gly Phe Lys Leu Trp Leu Gly Pro Thr Phe 
                85                  90                  95      


Pro Leu Leu Ile Leu Cys His Pro Asp Ile Ile Arg Pro Ile Thr Ser 
            100                 105                 110         


Ala Ser Ala Ala Val Ala Pro Lys Asp Met Ile Phe Tyr Gly Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Lys Ser Val Asn Ile Met His Asp 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Glu Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Phe Val Glu Lys Arg Asn Gln Gln Ile Leu 
225                 230                 235                 240 


Leu His Thr Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys His Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Cys Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Leu Lys 
        275                 280                 285             


Asn Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Gln Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Ile 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Phe Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Val Cys Leu Ile Asn Ile Ile Gly Ile His Tyr Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Gln Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu His Phe Arg Ile Leu Pro Thr His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Ile Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly Ala Asn Ser Gln 
        515                 520                 


<210>  15
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Leu Leu Ser Leu Pro Trp Leu Gly Leu Arg Pro Val Ala Thr 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Val Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr Asn Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Trp Gly His Leu 
    50                  55                  60                  


Gly Leu Ile Thr Pro Thr Glu Glu Gly Leu Lys Asn Ser Thr Gln Met 
65                  70                  75                  80  


Ser Ala Thr Tyr Ser Gln Gly Phe Thr Val Trp Leu Gly Pro Ile Ile 
                85                  90                  95      


Pro Phe Ile Val Leu Cys His Pro Asp Thr Ile Arg Ser Ile Thr Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Asn Leu Phe Ile Arg Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Glu Gly Ile Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Ser Tyr Ile Thr Ile Phe Asn Lys Ser Ala Asn Ile Met Leu Asp 
                165                 170                 175     


Lys Trp Gln His Leu Ala Ser Glu Gly Ser Ser Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Arg Pro Ser Glu Tyr Ile Ala Thr 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Glu Lys Arg Ser Gln His Ile Leu 
225                 230                 235                 240 


Gln His Met Asp Phe Leu Tyr Tyr Leu Ser His Asp Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Arg 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Phe Lys 
        275                 280                 285             


Asp Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Ala Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Asp Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Val Lys Glu Ser Leu Arg Leu His Pro Pro Ala Pro Phe Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Thr Cys Leu Ile Asp Ile Ile Gly Val His His Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ser Lys Gly Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Met Leu Leu His Phe Arg Phe Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Leu Glu Leu Ile Met Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Asn Val Ser Leu Gln 
        515                 520                 


<210>  16
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Pro Ile Thr Asp Arg Leu Leu His Leu Leu Gly Leu Glu Lys 
1               5                   10                  15      


Thr Ala Phe Arg Ile Tyr Ala Val Ser Thr Leu Leu Leu Phe Leu Leu 
            20                  25                  30          


Phe Phe Leu Phe Arg Leu Leu Leu Arg Phe Leu Arg Leu Cys Arg Ser 
        35                  40                  45              


Phe Tyr Ile Thr Cys Arg Arg Leu Arg Cys Phe Pro Gln Pro Pro Arg 
    50                  55                  60                  


Arg Asn Trp Leu Leu Gly His Leu Gly Met Tyr Leu Pro Asn Glu Ala 
65                  70                  75                  80  


Gly Leu Gln Asp Glu Lys Lys Val Leu Asp Asn Met His His Val Leu 
                85                  90                  95      


Leu Val Trp Met Gly Pro Val Leu Pro Leu Leu Val Leu Val His Pro 
            100                 105                 110         


Asp Tyr Ile Lys Pro Leu Leu Gly Ala Ser Ala Ala Ile Ala Pro Lys 
        115                 120                 125             


Asp Asp Leu Phe Tyr Gly Phe Leu Lys Pro Trp Leu Gly Asp Gly Leu 
    130                 135                 140                 


Leu Leu Ser Lys Gly Asp Lys Trp Ser Arg His Arg Arg Leu Leu Thr 
145                 150                 155                 160 


Pro Ala Phe His Phe Asp Ile Leu Lys Pro Tyr Met Lys Ile Phe Asn 
                165                 170                 175     


Gln Ser Ala Asp Ile Met His Ala Lys Trp Arg His Leu Ala Glu Gly 
            180                 185                 190         


Ser Ala Val Ser Leu Asp Met Phe Glu His Ile Ser Leu Met Thr Leu 
        195                 200                 205             


Asp Ser Leu Gln Lys Cys Val Phe Ser Tyr Asn Ser Asn Cys Gln Glu 
    210                 215                 220                 


Lys Met Ser Asp Tyr Ile Ser Ala Ile Ile Glu Leu Ser Ala Leu Ser 
225                 230                 235                 240 


Val Arg Arg Gln Tyr Arg Leu His His Tyr Leu Asp Phe Ile Tyr Tyr 
                245                 250                 255     


Arg Ser Ala Asp Gly Arg Arg Phe Arg Gln Ala Cys Asp Met Val His 
            260                 265                 270         


His Phe Thr Thr Glu Val Ile Gln Glu Arg Arg Arg Ala Leu Arg Gln 
        275                 280                 285             


Gln Gly Ala Glu Ala Trp Leu Lys Ala Lys Gln Gly Lys Thr Leu Asp 
    290                 295                 300                 


Phe Ile Asp Val Leu Leu Leu Ala Arg Asp Glu Asp Gly Lys Glu Leu 
305                 310                 315                 320 


Ser Asp Glu Asp Ile Arg Ala Glu Ala Asp Thr Phe Met Phe Glu Gly 
                325                 330                 335     


His Asp Thr Thr Ser Ser Gly Ile Ser Trp Met Leu Phe Asn Leu Ala 
            340                 345                 350         


Lys Tyr Pro Glu Tyr Gln Glu Lys Cys Arg Glu Glu Ile Gln Glu Val 
        355                 360                 365             


Met Lys Gly Arg Glu Leu Glu Glu Leu Glu Trp Asp Asp Leu Thr Gln 
    370                 375                 380                 


Leu Pro Phe Thr Thr Met Cys Ile Lys Glu Ser Leu Arg Gln Tyr Pro 
385                 390                 395                 400 


Pro Val Thr Leu Val Ser Arg Gln Cys Thr Glu Asp Ile Lys Leu Pro 
                405                 410                 415     


Asp Gly Arg Ile Ile Pro Lys Gly Ile Ile Cys Leu Val Ser Ile Tyr 
            420                 425                 430         


Gly Thr His His Asn Pro Thr Val Trp Pro Asp Ser Lys Val Tyr Asn 
        435                 440                 445             


Pro Tyr Arg Phe Asp Pro Asp Asn Pro Gln Gln Arg Ser Pro Leu Ala 
    450                 455                 460                 


Tyr Val Pro Phe Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Ser Phe 
465                 470                 475                 480 


Ala Met Ala Glu Leu Arg Val Val Val Ala Leu Thr Leu Leu Arg Phe 
                485                 490                 495     


Arg Leu Ser Val Asp Arg Thr Arg Lys Val Arg Arg Lys Pro Glu Leu 
            500                 505                 510         


Ile Leu Arg Thr Glu Asn Gly Leu Trp Leu Lys Val Glu Pro Leu Pro 
        515                 520                 525             


Pro Arg Ala 
    530     


<210>  17
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Phe Ser Trp Leu Glu Thr Arg Trp Ala Arg Pro Phe Tyr Leu 
1               5                   10                  15      


Ala Phe Val Phe Cys Leu Ala Leu Gly Leu Leu Gln Ala Ile Lys Leu 
            20                  25                  30          


Tyr Leu Arg Arg Gln Arg Leu Leu Arg Asp Leu Arg Pro Phe Pro Ala 
        35                  40                  45              


Pro Pro Thr His Trp Phe Leu Gly His Gln Lys Phe Ile Gln Asp Asp 
    50                  55                  60                  


Asn Met Glu Lys Leu Glu Glu Ile Ile Glu Lys Tyr Pro Arg Ala Phe 
65                  70                  75                  80  


Pro Phe Trp Ile Gly Pro Phe Gln Ala Phe Phe Cys Ile Tyr Asp Pro 
                85                  90                  95      


Asp Tyr Ala Lys Thr Leu Leu Ser Arg Thr Asp Pro Lys Ser Gln Tyr 
            100                 105                 110         


Leu Gln Lys Phe Ser Pro Pro Leu Leu Gly Lys Gly Leu Ala Ala Leu 
        115                 120                 125             


Asp Gly Pro Lys Trp Phe Gln His Arg Arg Leu Leu Thr Pro Gly Phe 
    130                 135                 140                 


His Phe Asn Ile Leu Lys Ala Tyr Ile Glu Val Met Ala His Ser Val 
145                 150                 155                 160 


Lys Met Met Leu Asp Lys Trp Glu Lys Ile Cys Ser Thr Gln Asp Thr 
                165                 170                 175     


Ser Val Glu Val Tyr Glu His Ile Asn Ser Met Ser Leu Asp Ile Ile 
            180                 185                 190         


Met Lys Cys Ala Phe Ser Lys Glu Thr Asn Cys Gln Thr Asn Ser Thr 
        195                 200                 205             


His Asp Pro Tyr Ala Lys Ala Ile Phe Glu Leu Ser Lys Ile Ile Phe 
    210                 215                 220                 


His Arg Leu Tyr Ser Leu Leu Tyr His Ser Asp Ile Ile Phe Lys Leu 
225                 230                 235                 240 


Ser Pro Gln Gly Tyr Arg Phe Gln Lys Leu Ser Arg Val Leu Asn Gln 
                245                 250                 255     


Tyr Thr Asp Thr Ile Ile Gln Glu Arg Lys Lys Ser Leu Gln Ala Gly 
            260                 265                 270         


Val Lys Gln Asp Asn Thr Pro Lys Arg Lys Tyr Gln Asp Phe Leu Asp 
        275                 280                 285             


Ile Val Leu Ser Ala Lys Asp Glu Ser Gly Ser Ser Phe Ser Asp Ile 
    290                 295                 300                 


Asp Val His Ser Glu Val Ser Thr Phe Leu Leu Ala Gly His Asp Thr 
305                 310                 315                 320 


Leu Ala Ala Ser Ile Ser Trp Ile Leu Tyr Cys Leu Ala Leu Asn Pro 
                325                 330                 335     


Glu His Gln Glu Arg Cys Arg Glu Glu Val Arg Gly Ile Leu Gly Asp 
            340                 345                 350         


Gly Ser Ser Ile Thr Trp Asp Gln Leu Gly Glu Met Ser Tyr Thr Thr 
        355                 360                 365             


Met Cys Ile Lys Glu Thr Cys Arg Leu Ile Pro Ala Val Pro Ser Ile 
    370                 375                 380                 


Ser Arg Asp Leu Ser Lys Pro Leu Thr Phe Pro Asp Gly Cys Thr Leu 
385                 390                 395                 400 


Pro Ala Gly Ile Thr Val Val Leu Ser Ile Trp Gly Leu His His Asn 
                405                 410                 415     


Pro Ala Val Trp Lys Asn Pro Lys Val Phe Asp Pro Leu Arg Phe Ser 
            420                 425                 430         


Gln Glu Asn Ser Asp Gln Arg His Pro Tyr Ala Tyr Leu Pro Phe Ser 
        435                 440                 445             


Ala Gly Ser Arg Asn Cys Ile Gly Gln Glu Phe Ala Met Ile Glu Leu 
    450                 455                 460                 


Lys Val Thr Ile Ala Leu Ile Leu Leu His Phe Arg Val Thr Pro Asp 
465                 470                 475                 480 


Pro Thr Arg Pro Leu Thr Phe Pro Asn His Phe Ile Leu Lys Pro Lys 
                485                 490                 495     


Asn Gly Met Tyr Leu His Leu Lys Lys Leu Ser Glu Cys 
            500                 505                 


<210>  18
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Pro Ser Trp Leu Gln Glu Leu Met Ala His Pro Phe Leu Leu 
1               5                   10                  15      


Leu Ile Leu Leu Cys Met Ser Leu Leu Leu Phe Gln Val Ile Arg Leu 
            20                  25                  30          


Tyr Gln Arg Arg Arg Trp Met Ile Arg Ala Leu His Leu Phe Pro Ala 
        35                  40                  45              


Pro Pro Ala His Trp Phe Tyr Gly His Lys Glu Phe Tyr Pro Val Lys 
    50                  55                  60                  


Glu Phe Glu Val Tyr His Lys Leu Met Glu Lys Tyr Pro Cys Ala Val 
65                  70                  75                  80  


Pro Leu Trp Val Gly Pro Phe Thr Met Phe Phe Ser Val His Asp Pro 
                85                  90                  95      


Asp Tyr Ala Lys Ile Leu Leu Lys Arg Gln Asp Pro Lys Ser Ala Val 
            100                 105                 110         


Ser His Lys Ile Leu Glu Ser Trp Val Gly Arg Gly Leu Val Thr Leu 
        115                 120                 125             


Asp Gly Ser Lys Trp Lys Lys His Arg Gln Ile Val Lys Pro Gly Phe 
    130                 135                 140                 


Asn Ile Ser Ile Leu Lys Ile Phe Ile Thr Met Met Ser Glu Ser Val 
145                 150                 155                 160 


Arg Met Met Leu Asn Lys Trp Glu Glu His Ile Ala Gln Asn Ser Arg 
                165                 170                 175     


Leu Glu Leu Phe Gln His Val Ser Leu Met Thr Leu Asp Ser Ile Met 
            180                 185                 190         


Lys Cys Ala Phe Ser His Gln Gly Ser Ile Gln Leu Asp Ser Thr Leu 
        195                 200                 205             


Asp Ser Tyr Leu Lys Ala Val Phe Asn Leu Ser Lys Ile Ser Asn Gln 
    210                 215                 220                 


Arg Met Asn Asn Phe Leu His His Asn Asp Leu Val Phe Lys Phe Ser 
225                 230                 235                 240 


Ser Gln Gly Gln Ile Phe Ser Lys Phe Asn Gln Glu Leu His Gln Phe 
                245                 250                 255     


Thr Glu Lys Val Ile Gln Asp Arg Lys Glu Ser Leu Lys Asp Lys Leu 
            260                 265                 270         


Lys Gln Asp Thr Thr Gln Lys Arg Arg Trp Asp Phe Leu Asp Ile Leu 
        275                 280                 285             


Leu Ser Ala Lys Ser Glu Asn Thr Lys Asp Phe Ser Glu Ala Asp Leu 
    290                 295                 300                 


Gln Ala Glu Val Lys Thr Phe Met Phe Ala Gly His Asp Thr Thr Ser 
305                 310                 315                 320 


Ser Ala Ile Ser Trp Ile Leu Tyr Cys Leu Ala Lys Tyr Pro Glu His 
                325                 330                 335     


Gln Gln Arg Cys Arg Asp Glu Ile Arg Glu Leu Leu Gly Asp Gly Ser 
            340                 345                 350         


Ser Ile Thr Trp Glu His Leu Ser Gln Met Pro Tyr Thr Thr Met Cys 
        355                 360                 365             


Ile Lys Glu Cys Leu Arg Leu Tyr Ala Pro Val Val Asn Ile Ser Arg 
    370                 375                 380                 


Leu Leu Asp Lys Pro Ile Thr Phe Pro Asp Gly Arg Ser Leu Pro Ala 
385                 390                 395                 400 


Gly Ile Thr Val Phe Ile Asn Ile Trp Ala Leu His His Asn Pro Tyr 
                405                 410                 415     


Phe Trp Glu Asp Pro Gln Val Phe Asn Pro Leu Arg Phe Ser Arg Glu 
            420                 425                 430         


Asn Ser Glu Lys Ile His Pro Tyr Ala Phe Ile Pro Phe Ser Ala Gly 
        435                 440                 445             


Leu Arg Asn Cys Ile Gly Gln His Phe Ala Ile Ile Glu Cys Lys Val 
    450                 455                 460                 


Ala Val Ala Leu Thr Leu Leu Arg Phe Lys Leu Ala Pro Asp His Ser 
465                 470                 475                 480 


Arg Pro Pro Gln Pro Val Arg Gln Val Val Leu Lys Ser Lys Asn Gly 
                485                 490                 495     


Ile His Val Phe Ala Lys Lys Val Cys 
            500                 505 


<210>  19
<211>  525
<212>  PRT
<213>  Pan troglodytes

<400>  19

Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Thr Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Thr Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Ile Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Lys Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Lys Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Lys Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Ser Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Arg 
        515                 520                 525 


<210>  20
<211>  525
<212>  PRT
<213>  Macaca mulatta

<400>  20

Met Ala Gly Ile Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Ser Tyr Val Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Arg Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Val Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Lys Ile Leu His Ala Phe Thr Asn Asn Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Val Asp Glu Asp Cys Arg Gly Asp Gly Arg Asp 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Met Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Arg Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Arg Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Thr Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Pro 
        515                 520                 525 


<210>  21
<211>  539
<212>  PRT
<213>  Canis lupus

<400>  21

Met Leu Lys Val Lys Trp Lys Glu Asn Val Phe Arg Glu Gly Asp Lys 
1               5                   10                  15      


Asp Ser Asn Met Leu Asp Ala Val Gln Leu Pro Ser Ile Lys Val Glu 
            20                  25                  30          


Ser Ala Leu Ser Asp Ala Glu Ala Gly Gly Ser Pro Gly Gly Arg Arg 
        35                  40                  45              


Pro Val Leu Thr Val Glu Arg Gly Arg Leu Ala Gln Gly Ser Met Ser 
    50                  55                  60                  


Ser Leu Leu Lys Asn Pro Lys Asp Thr Thr Arg Asn Ser Leu Lys Ile 
65                  70                  75                  80  


Lys Tyr Phe Leu Pro Glu Phe Phe Gln Gln Val Ile Leu Tyr Ser Glu 
                85                  90                  95      


Glu Ser Arg His Leu Pro Leu Leu Lys Leu Trp Leu Gly Pro Ile Pro 
            100                 105                 110         


Ile Val Ala Ile Tyr Ser Ala Glu Asn Val Glu Val Ile Leu Thr Ser 
        115                 120                 125             


Ser Arg Gln Ile Asp Lys Ser Tyr Val Tyr Lys Phe Leu Glu Pro Trp 
    130                 135                 140                 


Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg Ser Arg 
145                 150                 155                 160 


Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu Asp Phe 
                165                 170                 175     


Leu Asp Val Met Asn Glu His Ala Asn Ile Leu Val Asn Lys Leu Glu 
            180                 185                 190         


Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile Thr Leu 
        195                 200                 205             


Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn Ile Gly 
    210                 215                 220                 


Ala Gln Asn Asn Glu Asp Ser Glu Tyr Val Arg Ala Ile Tyr Arg Met 
225                 230                 235                 240 


Ser Asp Thr Ile His Arg Arg Met Lys Met Pro Trp Leu Trp Leu Asp 
                245                 250                 255     


Phe Leu Phe Leu Met Phe Lys Glu Gly Arg Glu His Lys Arg Asn Leu 
            260                 265                 270         


Glu Ile Leu His Asn Phe Thr Asn Asn Val Ile Thr Glu Arg Ala Ser 
        275                 280                 285             


Glu Leu Lys Arg Asp Glu Glu His Gly Ser Ala Asp Lys Asp Cys Ser 
    290                 295                 300                 


Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu Asn Val 
305                 310                 315                 320 


Thr Asp Asp Glu Gly Asn Lys Leu Arg His Glu Asp Val Arg Glu Glu 
                325                 330                 335     


Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala Ala Ile 
            340                 345                 350         


Asn Trp Ser Leu Tyr Leu Leu Gly Ser Tyr Pro Glu Val Gln Lys Gln 
        355                 360                 365             


Val Asp Ser Glu Leu Glu Asp Val Phe Gly Lys Ser Asp Arg Pro Ala 
    370                 375                 380                 


Thr Leu Glu Asp Leu Lys Lys Leu Lys Tyr Leu Glu Cys Val Ile Lys 
385                 390                 395                 400 


Glu Ser Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg Asn Leu 
                405                 410                 415     


Asn Glu Asp Cys Val Val Ala Gly Tyr Lys Val Val Lys Gly Ser Gln 
            420                 425                 430         


Ala Ile Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr Phe Pro 
        435                 440                 445             


Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn Leu Gln 
    450                 455                 460                 


Gly Arg His Pro Tyr Ala Tyr Ile Pro Phe Ser Ala Gly Pro Arg Asn 
465                 470                 475                 480 


Cys Ile Gly Gln Arg Phe Ala Ile Met Glu Glu Lys Thr Val Leu Ser 
                485                 490                 495     


Cys Val Leu Arg His Phe Trp Val Glu Ser Asn Gln Lys Arg Glu Glu 
            500                 505                 510         


Leu Gly Leu Ala Gly Glu Leu Ile Leu Arg Pro Thr Asn Gly Ile Trp 
        515                 520                 525             


Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Ser 
    530                 535                 


<210>  22
<211>  527
<212>  PRT
<213>  Bos Taurus

<400>  22

Met Leu Ala Pro Trp Leu Leu Ser Val Gly Pro Lys Leu Leu Leu Trp 
1               5                   10                  15      


Ser Gly Leu Cys Ala Val Ser Leu Ala Gly Ala Thr Leu Thr Leu Asn 
            20                  25                  30          


Leu Leu Lys Met Val Ala Ser Tyr Ala Arg Lys Trp Arg Gln Met Arg 
        35                  40                  45              


Pro Val Pro Thr Ile Gly Asp Pro Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Met Met Lys Pro Asp Ala Arg Asp Phe Phe Gln Gln Ile Ile Asp Phe 
65                  70                  75                  80  


Thr Glu Glu Cys Arg His Leu Pro Leu Leu Lys Leu Trp Leu Gly Pro 
                85                  90                  95      


Val Pro Leu Val Ala Leu Tyr Asn Ala Glu Thr Val Glu Val Ile Leu 
            100                 105                 110         


Ser Ser Ser Lys His Ile Glu Lys Ser Tyr Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Val Met Asn Glu Gln Ala Asn Ile Leu Val Thr Lys 
                165                 170                 175     


Leu Glu Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Val 
            180                 185                 190         


Thr Leu Cys Thr Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Arg Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Asp Ser Ile His Gln Arg Met Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Ile Phe Tyr Met Phe Lys Asn Gly Arg Glu His Arg Arg 
                245                 250                 255     


Ser Leu Lys Ile Val His Asp Phe Thr Asn Asn Val Ile Thr Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Lys Arg His Glu Glu Gly Thr Ser Asn Asp Lys Glu 
        275                 280                 285             


Lys Asp Phe Pro Pro Arg Lys Thr Lys Cys Arg Ala Phe Leu Asp Leu 
    290                 295                 300                 


Leu Leu Asn Val Thr Asp Asp Gln Gly Asn Lys Leu Ser His Glu Asp 
305                 310                 315                 320 


Ile Arg Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr 
                325                 330                 335     


Ala Ala Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Trp Tyr Pro Glu 
            340                 345                 350         


Val Gln Gln Arg Val Asp Thr Glu Leu Glu Glu Val Phe Gly Lys Ser 
        355                 360                 365             


Asp Arg Pro Val Thr Leu Glu Asp Leu Lys Lys Leu Lys Tyr Leu Asp 
    370                 375                 380                 


Cys Val Ile Lys Glu Ser Leu Arg Leu Phe Pro Ser Val Pro Phe Phe 
385                 390                 395                 400 


Ala Arg Asn Leu Thr Glu Asp Cys Glu Val Ala Gly His Lys Ile Val 
                405                 410                 415     


Gln Gly Cys Gln Val Ile Ile Val Pro Tyr Ala Leu His Arg Asp Pro 
            420                 425                 430         


Lys Tyr Phe Pro Asp Pro Glu Glu Phe Lys Pro Glu Arg Phe Phe Pro 
        435                 440                 445             


Glu Asn Leu Lys Gly Arg His Thr Tyr Ala Tyr Val Pro Phe Ser Ala 
    450                 455                 460                 


Gly Pro Arg Asn Cys Ile Gly Gln Lys Phe Ala Ile Met Glu Glu Lys 
465                 470                 475                 480 


Thr Ile Leu Ser Cys Ile Leu Arg His Phe Trp Val Glu Ser Asn Gln 
                485                 490                 495     


Lys Arg Glu Glu Leu Gly Leu Ala Gly Glu Leu Ile Leu Arg Pro Ser 
            500                 505                 510         


Asn Gly Ile Trp Ile Lys Leu Lys Arg Arg Asn Thr Asp Glu Ser 
        515                 520                 525         


<210>  23
<211>  525
<212>  PRT
<213>  Mus musculus

<400>  23

Met Leu Trp Leu Trp Leu Gly Leu Ser Gly Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Thr Ile Leu Ile Ser 
            20                  25                  30          


Ile Phe Pro Met Leu Val Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Ser Ile Pro Ser Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Tyr Met Lys Pro Asn Asn Ala Glu Phe Phe Gln Gln Leu Ile Tyr Tyr 
65                  70                  75                  80  


Thr Glu Glu Phe Arg His Leu Pro Ile Ile Lys Leu Trp Ile Gly Pro 
                85                  90                  95      


Val Pro Leu Val Ala Leu Tyr Lys Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Phe Leu Tyr Lys Phe Leu Gln 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Ser Lys Trp Arg 
    130                 135                 140                 


Thr Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asn Phe Leu Asp Val Met Asn Glu Gln Ala Asn Ile Leu Val Asn Lys 
                165                 170                 175     


Leu Glu Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asn Asp Ser Glu Tyr Val Arg Thr Val Tyr 
    210                 215                 220                 


Arg Met Ser Asp Met Ile Tyr Arg Arg Met Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Phe Asp Leu Trp Tyr Leu Val Phe Lys Glu Gly Arg Asp His Lys Arg 
                245                 250                 255     


Gly Leu Lys Cys Leu His Thr Phe Thr Asn Asn Val Ile Ala Glu Arg 
            260                 265                 270         


Val Lys Glu Arg Lys Ala Glu Glu Asp Trp Thr Gly Ala Gly Arg Gly 
        275                 280                 285             


Pro Ile Pro Ser Lys Asn Lys Arg Lys Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Glu Glu Gly Asn Arg Leu Ser Gln Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Thr Asn Pro Glu Val Gln 
            340                 345                 350         


Arg Lys Val Asp Gln Glu Leu Asp Glu Val Phe Gly Arg Ser His Arg 
        355                 360                 365             


Pro Val Thr Leu Glu Asp Leu Lys Lys Leu Lys Tyr Leu Asp Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Val Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Leu Ser Glu Asp Cys Glu Val Gly Gly Tyr Lys Val Thr Lys Gly 
                405                 410                 415     


Thr Glu Ala Ile Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asp Pro Glu Glu Phe Arg Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ser Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ala Cys Ile Leu Arg Gln Phe Trp Val Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Ala Gly Asp Leu Ile Leu Arg Pro Asn Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg His Glu Asp Asp Pro 
        515                 520                 525 


<210>  24
<211>  525
<212>  PRT
<213>  Rattus norvegicus

<400>  24

Met Leu Trp Leu Trp Leu Gly Leu Ser Gly Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Val Ser Val Ala Gly Ala Thr Val Leu Leu Asn 
            20                  25                  30          


Ile Leu Gln Met Leu Val Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Ser Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Phe Met Lys Pro Asn Asn Thr Glu Phe Phe Gln Gln Ile Ile Gln Tyr 
65                  70                  75                  80  


Thr Glu Glu Phe Arg His Leu Pro Ile Ile Lys Leu Trp Ile Gly Pro 
                85                  90                  95      


Val Pro Leu Val Ala Leu Tyr Lys Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Phe Met Tyr Lys Phe Leu Gln 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Ser Lys Trp Arg 
    130                 135                 140                 


Ala Arg Arg Lys Met Leu Thr Pro Ser Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Val Met Asn Glu Gln Ala Asn Ile Leu Val Asn Lys 
                165                 170                 175     


Leu Glu Lys His Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Pro Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Gly Asp Ser Glu Tyr Val Arg Thr Val Tyr 
    210                 215                 220                 


Arg Met Ser Asp Met Ile Tyr Arg Arg Met Lys Met Pro Trp Phe Trp 
225                 230                 235                 240 


Phe Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Arg Asp His Lys Lys 
                245                 250                 255     


Gly Leu Lys Ser Leu His Thr Phe Thr Asn Asn Val Ile Ala Glu Arg 
            260                 265                 270         


Val Asn Ala Arg Lys Ala Glu Gln Asp Cys Ile Gly Ala Gly Arg Gly 
        275                 280                 285             


Pro Leu Pro Ser Lys Thr Lys Arg Lys Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Glu Glu Gly Asn Lys Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Arg Lys Val Asp Lys Glu Leu Asp Asp Val Phe Gly Arg Ser His Arg 
        355                 360                 365             


Pro Val Thr Leu Glu Asp Leu Lys Lys Leu Lys Tyr Leu Asp Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Val Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Leu Ser Glu Asp Cys Glu Val Ala Gly Tyr Lys Ile Ser Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asp Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ser Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ala Cys Ile Leu Arg Glu Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Ala Gly Asp Leu Ile Leu Arg Pro Asn Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg His Glu Asp Asp Pro 
        515                 520                 525 


<210>  25
<211>  530
<212>  PRT
<213>  Gallus gallus

<400>  25

Met Ala Met Glu Ile Thr Leu Gly Ser Met Glu Gly Thr Gln Leu Leu 
1               5                   10                  15      


Pro Trp Val Ala Gly Ala Ile Thr Leu Leu Leu Thr Val Val Thr Val 
            20                  25                  30          


His Phe Leu Pro Ser Leu Leu Asn Tyr Trp Trp Trp Trp Trp Val Met 
        35                  40                  45              


Lys Pro Ile Pro Gly Ile Arg Pro Cys Tyr Pro Phe Val Gly Asn Ala 
    50                  55                  60                  


Leu Leu Leu Glu Arg Asn Gly Glu Gly Phe Phe Lys Gln Leu Gln Gln 
65                  70                  75                  80  


Tyr Ala Asp Glu Phe Arg Lys Met Pro Met Phe Lys Leu Trp Leu Gly 
                85                  90                  95      


Pro Leu Pro Val Thr Val Leu Phe His Pro Asp Ser Val Glu Val Ile 
            100                 105                 110         


Leu Ser Ser Ser Lys His Ile Lys Lys Ser Phe Leu Tyr Thr Phe Leu 
        115                 120                 125             


His Pro Trp Leu Gly Thr Gly Leu Leu Thr Ser Thr Gly Asp Lys Trp 
    130                 135                 140                 


Arg Ser Arg Arg Lys Met Ile Thr Pro Thr Phe His Phe Ala Ile Leu 
145                 150                 155                 160 


Asn Asp Phe Leu Glu Val Met Asn Glu Gln Gly Gly Val Leu Leu Glu 
                165                 170                 175     


Lys Leu Glu Lys His Val Asp Lys Glu Pro Phe Asn Ile Phe Thr Asp 
            180                 185                 190         


Ile Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys 
        195                 200                 205             


Asn Leu Gly Ala Gln Asp Asn Lys Asp Ser Glu Tyr Val Arg Ala Val 
    210                 215                 220                 


Tyr Arg Met Ser Asp Leu Ile Gln Gln Arg Gln Lys Ser Pro Trp Leu 
225                 230                 235                 240 


Trp His Asp Leu Met Tyr Leu Leu Phe Lys Glu Gly Arg Glu His Glu 
                245                 250                 255     


Arg Asn Leu Lys Ile Leu His Gly Phe Thr Asp Thr Val Ile Ala Glu 
            260                 265                 270         


Lys Val Ala Glu Leu Glu Asn Thr Lys Leu Thr Lys His Asp Thr Asp 
        275                 280                 285             


Val Asn Thr Glu Glu Glu Ser Gly Ser Lys Lys Arg Glu Ala Phe Leu 
    290                 295                 300                 


Asp Met Leu Leu Asn Ala Thr Asp Asp Glu Gly Lys Lys Leu Ser Tyr 
305                 310                 315                 320 


Lys Asp Ile Arg Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp 
                325                 330                 335     


Thr Thr Ala Ala Ala Met Asn Trp Val Leu Tyr Leu Leu Gly His His 
            340                 345                 350         


Pro Glu Ala Gln Lys Lys Val His Gln Glu Leu Asp Glu Val Phe Gly 
        355                 360                 365             


Asn Thr Glu Arg Pro Val Thr Val Asp Asp Leu Lys Lys Leu Arg Tyr 
    370                 375                 380                 


Leu Glu Cys Val Val Lys Glu Ala Leu Arg Leu Phe Pro Ser Val Pro 
385                 390                 395                 400 


Met Phe Ala Arg Ser Leu Gln Glu Asp Cys Tyr Ile Ser Gly Tyr Lys 
                405                 410                 415     


Leu Pro Lys Gly Thr Asn Val Leu Val Leu Thr Tyr Val Leu His Arg 
            420                 425                 430         


Asp Pro Glu Ile Phe Pro Glu Pro Asp Glu Phe Arg Pro Glu Arg Phe 
        435                 440                 445             


Phe Pro Glu Asn Ser Lys Gly Arg His Pro Tyr Ala Tyr Val Pro Phe 
    450                 455                 460                 


Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Arg Phe Ala Gln Met Glu 
465                 470                 475                 480 


Glu Lys Thr Leu Leu Ala Leu Ile Leu Arg Arg Phe Trp Val Asp Cys 
                485                 490                 495     


Ser Gln Lys Pro Glu Glu Leu Gly Leu Ser Gly Glu Leu Ile Leu Arg 
            500                 505                 510         


Pro Asn Asn Gly Ile Trp Val Gln Leu Lys Arg Arg Pro Lys Thr Val 
        515                 520                 525             


Thr Glu 
    530 


<210>  26
<211>  523
<212>  PRT
<213>  Xenopus tropicalis

<400>  26

Met Glu Leu Gly Gly Glu Val His Leu Leu Val Trp Val Ala Ala Ala 
1               5                   10                  15      


Val Val Leu Leu Thr Leu Leu Ala Leu Ser Ile Leu Pro Ala Leu Gln 
            20                  25                  30          


Asp Tyr Val Arg Lys Arg Arg Ile Leu Lys Pro Ile Pro Gly Pro Gly 
        35                  40                  45              


Pro Asn Tyr Pro Leu Ile Gly Asp Ala Leu Phe Leu Lys Asn Asn Gly 
    50                  55                  60                  


Gly Asp Phe Phe Leu Gln Ile Cys Glu Tyr Thr Glu Ser Tyr Arg Leu 
65                  70                  75                  80  


Gln Pro Leu Leu Lys Val Trp Ile Gly Thr Ile Pro Phe Ile Val Val 
                85                  90                  95      


Tyr His Ala Asp Thr Val Glu Pro Val Leu Ser Ser Ser Lys His Met 
            100                 105                 110         


Asp Lys Ala Phe Leu Tyr Lys Phe Leu His Pro Trp Leu Gly Lys Gly 
        115                 120                 125             


Leu Leu Thr Ser Thr Gly Glu Lys Trp Arg Ser Arg Arg Lys Met Ile 
    130                 135                 140                 


Thr Pro Thr Phe His Phe Ala Ile Leu Ser Glu Phe Leu Glu Val Met 
145                 150                 155                 160 


Asn Glu Gln Ser Lys Ile Leu Val Glu Lys Leu Gln Thr His Val Asp 
                165                 170                 175     


Gly Glu Ser Phe Asp Cys Phe Met Asp Val Thr Leu Cys Ala Leu Asp 
            180                 185                 190         


Ile Ile Ser Glu Thr Ala Met Gly Arg Lys Ile Gln Ala Gln Ser Asn 
        195                 200                 205             


Arg Asp Ser Glu Tyr Val Gln Ala Ile Tyr Lys Met Ser Asp Ile Ile 
    210                 215                 220                 


Gln Arg Arg Gln Lys Met Pro Trp Leu Trp Leu Asp Phe Leu Tyr Ala 
225                 230                 235                 240 


His Leu Arg Asp Gly Lys Glu His Asp Lys Asn Leu Lys Ile Leu His 
                245                 250                 255     


Ser Phe Thr Asp Lys Ala Ile Leu Glu Arg Ala Glu Glu Leu Lys Lys 
            260                 265                 270         


Met Gly Glu Gln Lys Lys Glu His Cys Asp Ser Asp Pro Glu Ser Asp 
        275                 280                 285             


Lys Pro Lys Lys Arg Ser Ala Phe Leu Asp Met Leu Leu Met Ala Thr 
    290                 295                 300                 


Asp Asp Ala Gly Asn Lys Met Ser Tyr Met Asp Ile Arg Glu Glu Val 
305                 310                 315                 320 


Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala Ala Leu Asn 
                325                 330                 335     


Trp Ser Leu Phe Leu Leu Gly Ser His Pro Glu Ala Gln Arg Gln Val 
            340                 345                 350         


His Lys Glu Leu Asp Glu Val Phe Gly Lys Ser Asp Arg Pro Val Thr 
        355                 360                 365             


Met Asp Asp Leu Lys Lys Leu Arg Tyr Leu Glu Ala Val Ile Lys Glu 
    370                 375                 380                 


Ser Leu Arg Ile Tyr Pro Ser Val Pro Leu Phe Gly Arg Thr Val Thr 
385                 390                 395                 400 


Glu Asp Cys Ser Ile Arg Gly Phe His Val Pro Lys Gly Val Asn Val 
                405                 410                 415     


Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Glu Tyr Phe Pro Glu 
            420                 425                 430         


Pro Glu Glu Phe Arg Pro Glu Arg Phe Phe Pro Glu Asn Ala Ser Gly 
        435                 440                 445             


Arg Asn Pro Tyr Ala Tyr Ile Pro Phe Ser Ala Gly Leu Arg Asn Cys 
    450                 455                 460                 


Ile Gly Gln Arg Phe Ala Leu Met Glu Glu Lys Val Val Leu Ser Ser 
465                 470                 475                 480 


Ile Leu Arg Asn Tyr Trp Val Glu Ala Ser Gln Lys Arg Glu Glu Leu 
                485                 490                 495     


Cys Leu Leu Gly Glu Leu Ile Leu Arg Pro Gln Asp Gly Met Trp Ile 
            500                 505                 510         


Lys Leu Lys Asn Arg Glu Thr Ala Pro Thr Ala 
        515                 520             


<210>  27
<211>  469
<212>  PRT
<213>  Equus caballus

<400>  27

Met Phe Val Leu Ile Glu Phe Lys Ile Lys Tyr Ser Leu Ser Asp Phe 
1               5                   10                  15      


Phe Gln Gln Leu Ile Tyr Tyr Thr Glu Glu Asn Arg His Leu Pro Leu 
            20                  25                  30          


Leu Lys Leu Trp Leu Gly Pro Val Pro Val Val Ile Phe Tyr Asn Ala 
        35                  40                  45              


Glu Asn Val Glu Val Ile Leu Thr Ser Ser Arg Gln Ile Asp Lys Ser 
    50                  55                  60                  


Tyr Met Tyr Lys Phe Leu Lys Pro Trp Leu Gly Leu Gly Leu Leu Thr 
65                  70                  75                  80  


Ser Thr Gly Asn Lys Trp Arg Ser Arg Arg Lys Met Leu Thr Pro Thr 
                85                  90                  95      


Phe His Phe Thr Asn Leu Glu Asp Phe Leu Asp Val Met Asn Glu Gln 
            100                 105                 110         


Ala Asn Ile Leu Val Asn Lys Leu Glu Lys His Val Asn Gln Glu Ala 
        115                 120                 125             


Phe Asn Cys Phe Leu Tyr Ile Thr Leu Cys Ala Leu Asp Ile Ile Cys 
    130                 135                 140                 


Glu Thr Ala Met Gly Lys Asn Ile Gly Ala Gln Arg Asn Asn Asp Ser 
145                 150                 155                 160 


Glu Tyr Val Arg Ala Val Tyr Arg Met Ser Asp Met Ile His Arg Arg 
                165                 170                 175     


Met Lys Met Pro Trp Leu Trp Leu Asp Ile Phe Phe Leu Met Phe Lys 
            180                 185                 190         


Glu Gly Arg Glu His Arg Arg Leu Leu Lys Ile Leu His Asn Phe Thr 
        195                 200                 205             


Asn Asn Val Ile Val Glu Arg Ala Ser Glu Met Lys Lys Asp Glu Glu 
    210                 215                 220                 


Arg Ser Arg Ser Asp Asp Gly Gly Ser Ala Pro Ser Lys Asn Lys Arg 
225                 230                 235                 240 


Arg Ala Phe Leu Asp Leu Leu Leu Asn Val Thr Asp Asp Glu Gly Asn 
                245                 250                 255     


Lys Leu Ser His Glu Asp Ile Arg Gln Glu Val Asp Thr Phe Met Phe 
            260                 265                 270         


Glu Gly His Asp Thr Thr Ala Ala Ala Ile Asn Trp Ser Leu Tyr Leu 
        275                 280                 285             


Leu Gly Cys Tyr Pro Glu Val Gln Lys Lys Val Asp Ser Glu Leu Glu 
    290                 295                 300                 


Glu Val Phe Gly Lys Ser Asp Arg Pro Ala Thr Leu Glu Asp Leu Lys 
305                 310                 315                 320 


Lys Leu Lys Tyr Leu Glu Cys Val Met Lys Glu Thr Leu Arg Leu Phe 
                325                 330                 335     


Pro Ser Val Pro Leu Phe Ala Arg Asn Leu Asn Glu Asp Cys Glu Val 
            340                 345                 350         


Ala Gly Tyr Lys Ile Val Lys Gly Ser Gln Ala Ile Ile Val Ser Tyr 
        355                 360                 365             


Ala Leu His Arg Asp Ser Arg Tyr Phe Pro Asn Pro Glu Glu Phe Lys 
    370                 375                 380                 


Pro Glu Arg Phe Phe Pro Glu Asn Ser Gln Gly Arg His Pro Tyr Ala 
385                 390                 395                 400 


Tyr Val Pro Phe Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Lys Phe 
                405                 410                 415     


Ala Val Met Glu Glu Lys Ile Ile Leu Ser Cys Ile Leu Arg His Phe 
            420                 425                 430         


Trp Val Glu Ser Asn Gln Lys Arg Glu Glu Leu Gly Leu Ala Gly Glu 
        435                 440                 445             


Leu Ile Leu Arg Pro Ser Asn Gly Ile Trp Ile Lys Leu Lys Arg Arg 
    450                 455                 460                 


Asn Thr Glu Glu Ser 
465                 


<210>  28
<211>  524
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  28

Met Trp Leu Trp Leu Gly Leu Val Gly Gln Lys Leu Leu Phe Trp Gly 
1               5                   10                  15      


Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Ser Leu Phe Leu Asn Leu 
            20                  25                  30          


Leu Gln Met Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg Pro 
        35                  40                  45              


Ile Pro Thr Ile Gly Arg Pro Tyr Pro Leu Val Gly His Ala Leu Tyr 
    50                  55                  60                  


Met Lys Pro Ser Gly Lys Glu Phe Phe Gln Gln Leu Ile Gln Tyr Thr 
65                  70                  75                  80  


Glu Glu Tyr Arg His Leu Pro Leu Leu Lys Leu Trp Leu Gly Pro Leu 
                85                  90                  95      


Pro Ile Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu Asn 
            100                 105                 110         


Ser Ser Lys Gln Ile Asn Lys Ser Ser Met Tyr Gln Phe Leu Glu Pro 
        115                 120                 125             


Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Tyr Lys Trp Arg Ser 
    130                 135                 140                 


Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu Asp 
145                 150                 155                 160 


Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val His Lys Leu 
                165                 170                 175     


Glu Lys His Val Asp Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile Thr 
            180                 185                 190         


Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn Ile 
        195                 200                 205             


Gly Ala Gln Ser Asn Glu Asp Ser Glu Tyr Val Arg Ala Val Tyr Arg 
    210                 215                 220                 


Met Ser Asp Val Ile Phe Arg Arg Met Lys Met Pro Trp Leu Trp Leu 
225                 230                 235                 240 


Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Arg Cys 
                245                 250                 255     


Leu Lys Ile Leu His Arg Phe Thr Asn Asn Val Ile Ala Glu Arg Val 
            260                 265                 270         


Ser Glu Met Lys Thr Asp Glu Glu His Arg Asp Ala Asp Ser Asn Cys 
        275                 280                 285             


Ala Pro Ser Thr Met Lys Arg Lys Ala Phe Leu Asp Leu Leu Leu Thr 
    290                 295                 300                 


Val Thr Asp Glu Glu Gly Asn Lys Leu Ser His Glu Asp Ile Arg Glu 
305                 310                 315                 320 


Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala Ala 
                325                 330                 335     


Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser His Pro Glu Val Gln Arg 
            340                 345                 350         


Lys Val Asp Asp Glu Leu Asp Glu Val Phe Gly Lys Ser Asp Arg Pro 
        355                 360                 365             


Ala Thr Ser Glu Asp Leu Lys Lys Leu Lys Tyr Leu Glu Cys Val Ile 
    370                 375                 380                 


Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg Ser 
385                 390                 395                 400 


Leu Ser Asp Asp Cys Glu Val Ala Gly Phe Arg Val Val Lys Gly Thr 
                405                 410                 415     


Gln Ala Val Ile Val Pro Tyr Ala Leu His Arg Asp Pro Lys Tyr Phe 
            420                 425                 430         


Pro Asn Pro Glu Glu Phe Arg Pro Glu Arg Phe Phe Pro Glu Asn Ala 
        435                 440                 445             


Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro Arg 
    450                 455                 460                 


Asn Cys Ile Gly Gln Lys Phe Ala Ile Met Glu Glu Lys Thr Ile Leu 
465                 470                 475                 480 


Ser Cys Ile Leu Arg Lys Leu Trp Val Glu Ser Asn Gln Lys Met Glu 
                485                 490                 495     


Glu Leu Gly Leu Ala Gly Glu Leu Ile Leu Arg Pro Thr Asn Gly Ile 
            500                 505                 510         


Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Lys Ala 
        515                 520                 


<210>  29
<211>  535
<212>  PRT
<213>  Drosophila melanogaster

<400>  29

Met Ser Ser Lys Val Ile Thr Ser Leu Met Ala Glu Ser Ile Leu Leu 
1               5                   10                  15      


Ser Lys Val Gly Gln Val Ile Ser Gly Tyr Ser Pro Ile Thr Val Phe 
            20                  25                  30          


Leu Leu Gly Ser Ile Leu Ile Phe Leu Val Val Tyr Asn Lys Arg Arg 
        35                  40                  45              


Ser Arg Leu Val Lys Tyr Ile Glu Lys Ile Pro Gly Pro Ala Ala Met 
    50                  55                  60                  


Pro Phe Leu Gly Asn Ala Ile Glu Met Asn Val Asp His Asp Glu Leu 
65                  70                  75                  80  


Phe Asn Arg Val Ile Gly Met Gln Lys Leu Trp Gly Thr Arg Ile Gly 
                85                  90                  95      


Ile Asn Arg Val Trp Gln Gly Thr Ala Pro Arg Val Leu Leu Phe Glu 
            100                 105                 110         


Pro Glu Thr Val Glu Pro Ile Leu Asn Ser Gln Lys Phe Val Asn Lys 
        115                 120                 125             


Ser His Asp Tyr Asp Tyr Leu His Pro Trp Leu Gly Glu Gly Leu Leu 
    130                 135                 140                 


Thr Ser Thr Asp Arg Lys Trp His Ser Arg Arg Lys Ile Leu Thr Pro 
145                 150                 155                 160 


Ala Phe His Phe Lys Ile Leu Asp Asp Phe Ile Asp Val Phe Asn Glu 
                165                 170                 175     


Gln Ser Ala Val Leu Ala Arg Lys Leu Ala Val Glu Val Gly Ser Glu 
            180                 185                 190         


Ala Phe Asn Leu Phe Pro Tyr Val Thr Leu Cys Thr Leu Asp Ile Val 
        195                 200                 205             


Cys Glu Thr Ala Met Gly Arg Arg Ile Tyr Ala Gln Ser Asn Ser Glu 
    210                 215                 220                 


Ser Glu Tyr Val Lys Ala Val Tyr Gly Ile Gly Ser Ile Val Gln Ser 
225                 230                 235                 240 


Arg Gln Ala Lys Ile Trp Leu Gln Ser Asp Phe Ile Phe Ser Leu Thr 
                245                 250                 255     


Ala Glu Tyr Lys Leu His Gln Ser Tyr Ile Asn Thr Leu His Gly Phe 
            260                 265                 270         


Ser Asn Met Val Ile Arg Glu Arg Lys Ala Glu Leu Ala Ile Leu Gln 
        275                 280                 285             


Glu Asn Asn Asn Asn Asn Asn Asn Asn Ala Pro Asp Ala Tyr Asp Asp 
    290                 295                 300                 


Val Gly Lys Lys Lys Arg Leu Ala Phe Leu Asp Leu Leu Ile Asp Ala 
305                 310                 315                 320 


Ser Lys Glu Gly Thr Val Leu Ser Asn Glu Asp Ile Arg Glu Glu Val 
                325                 330                 335     


Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ser Ala Ala Ile Ser 
            340                 345                 350         


Trp Thr Leu Phe Leu Leu Gly Cys His Pro Glu Tyr Gln Glu Arg Val 
        355                 360                 365             


Val Glu Glu Leu Asp Ser Ile Phe Gly Asp Asp Lys Glu Thr Pro Ala 
    370                 375                 380                 


Thr Met Lys Asn Leu Met Asp Met Arg Tyr Leu Glu Cys Cys Ile Lys 
385                 390                 395                 400 


Asp Ser Leu Arg Leu Phe Pro Ser Val Pro Met Met Ala Arg Met Val 
                405                 410                 415     


Gly Glu Asp Val Asn Ile Gly Gly Lys Ile Val Pro Ala Gly Thr Gln 
            420                 425                 430         


Ala Ile Ile Met Thr Tyr Ala Leu His Arg Asn Pro Arg Val Phe Pro 
        435                 440                 445             


Lys Pro Glu Gln Phe Asn Pro Asp Asn Phe Leu Pro Glu Asn Cys Ala 
    450                 455                 460                 


Gly Arg His Pro Phe Ala Tyr Ile Pro Phe Ser Ala Gly Pro Arg Asn 
465                 470                 475                 480 


Cys Ile Gly Gln Lys Phe Ala Ile Leu Glu Glu Lys Ala Val Ile Ser 
                485                 490                 495     


Thr Val Leu Arg Lys Tyr Lys Ile Glu Ala Val Asp Arg Arg Glu Asp 
            500                 505                 510         


Leu Thr Leu Leu Gly Glu Leu Ile Leu Arg Pro Lys Asp Gly Leu Arg 
        515                 520                 525             


Val Lys Ile Thr Pro Arg Asp 
    530                 535 


<210>  30
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Phe Xaa Xaa Gly Xaa Xaa Xaa Cys Xaa Gly 
1               5                   10  


<210>  31
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetically generated consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Glu Xaa Xaa Arg 
1               


<210>  32
<211>  1715
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated promoter sequence

<400>  32
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      540

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      600

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      660

agtcgctgcg ttgccttcgc cccgtgcccc gctccgcgcc gcctcgcgcc gcccgccccg      720

gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg      780

ctgtaattag cgcttggttt aatgacggct cgtttctttt ctgtggctgc gtgaaagcct      840

taaagggctc cgggagggcc ctttgtgcgg gggggagcgg ctcggggggt gcgtgcgtgt      900

gtgtgtgcgt ggggagcgcc gcgtgcggcc cgcgctgccc ggcggctgtg agcgctgcgg      960

gcgcggcgcg gggctttgtg cgctccgcgt gtgcgcgagg ggagcgcggc cgggggcggt     1020

gccccgcggt gcgggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg     1080

gggggtgagc agggggtgtg ggcgcggcgg tcgggctgta acccccccct gcacccccct     1140

ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtgcggg gcgtggcgcg     1200

gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg ggcggggccg     1260

cctcgggccg gggagggctc gggggagggg cgcggcggcc ccggagcgcc ggcggctgtc     1320

gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg gcgcagggac     1380

ttcctttgtc ccaaatctgg cggagccgaa atctgggagg cgccgccgca ccccctctag     1440

cgggcgcggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga gggccttcgt     1500

gcgtcgccgc gccgccgtcc ccttctccat ctccagcctc ggggctgccg cagggggacg     1560

gctgccttcg ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg accggcggct     1620

ctagagcctc tgctaaccat gttcatgcct tcttcttttt cctacagctc ctgggcaacg     1680

tgctggttat tgtgctgtct catcattttg gcaaa                                1715


<210>  33
<211>  589
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  33
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  34
<211>  225
<212>  DNA
<213>  Bos Taurus

<400>  34
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210>  35
<211>  235
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated promoter sequence

<400>  35
gattggctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt       60

ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg tggcgcgggg taaactggga      120

aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac cgtatataag      180

tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa cacag           235


<210>  36
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated signal sequence

<400>  36
gatccaataa aagatcttta ttttcattag atctgtgtgt tggttttttg tgtg             54


<210>  37
<211>  6
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated signal sequence

<400>  37
gccacc                                                                   6


<210>  38
<211>  5
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated signal sequence

<400>  38
ccacc                                                                    5


<210>  39
<211>  120
<212>  DNA
<213>  Simian virus 40

<400>  39
ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat       60

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat      120


<210>  40
<211>  576
<212>  DNA
<213>  Cytomegalovirus

<400>  40
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa       60

cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata      120

atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag      180

tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc      240

cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta      300

tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg      360

cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      420

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      480

aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag      540

gtctatataa gcagagctgg tttagtgaac cgtcag                                576


<210>  41
<211>  1184
<212>  DNA
<213>  Homo sapiens

<400>  41
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtga                      1184


<210>  42
<211>  141
<212>  DNA
<213>  Adeno-associated virus

<400>  42
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  43
<211>  141
<212>  DNA
<213>  Adeno-associated virus

<400>  43
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  44
<211>  117
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated mutant adeno-associated virus 2 inverted 
       terminal repeat sequence

<400>  44
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtgg         117


<210>  45
<211>  141
<212>  DNA
<213>  Adeno-associated virus

<400>  45
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  46
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  46
caaacagaag catgtgatta tcattcaaag cgaacgggcc aatgaaatga acgccaatga       60


<210>  47
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  47
caaacagaag catgtgatta tcattcaaat catacaggtc atcgctgaac gggccaatga       60

aatgaacgcc aatga                                                        75


<210>  48
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  48
ugauuaucau ucaaagcgaa                                                   20


<210>  49
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  49
gauuaucauu caaagcgaac                                                   20


<210>  50
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  50
gauaaucaca ugcuucuguu                                                   20


<210>  51
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  51
uucauuggcg uucauuucau                                                   20


<210>  52
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  52
cacaugcuuc uguuuggacu                                                   20


<210>  53
<211>  16
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  53
guuuuagagc uaugcu                                                       16


<210>  54
<211>  67
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  54
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  55
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  55
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt tt                                                82


<210>  56
<211>  200
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  56
agaaaaataa atgaaagaaa ctagcatatt ttataagaaa atgtgttaac tagggtgcat       60

ccaagtccaa acagaagcat gtgattatca ttcaaatcat acaggtcatc gctgaacggg      120

ccaatgaaat gaacgccaat gaagactgta gaggtgatgg caggggctct gccccctcca      180

aaaataaacg cagggccttt                                                  200


<210>  57
<211>  200
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated oligonucleotide

<400>  57
aaaggccctg cgtttatttt tggagggggc agagcccctg ccatcacctc tacagtcttc       60

attggcgttc atttcattgg cccgttcagc gatgacctgt atgatttgaa tgataatcac      120

atgcttctgt ttggacttgg atgcacccta gttaacacat tttcttataa aatatgctag      180

tttctttcat ttatttttct                                                  200


<210>  58
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  58

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  59
<211>  1
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated spacer sequence

<400>  59

g                                                                        1   


<210>  60
<211>  4799
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated expression construct

<400>  60
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccaat tcagtcgata actataacgg tcctaaggta      180

gcgatttaaa tacgcgctct cttaaggtag ccccgggacg cgtcaattga gatctcgaca      240

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatgggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc      660

ccccctcccc acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg      720

gggcgggggg ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg      780

gcgaggcgga gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt      840

atggcgaggc ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc      900

gctgcgttgc cttcgccccg tgccccgctc cgcgccgcct cgcgccgccc gccccggctc      960

tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt     1020

aattagcgct tggtttaatg acggctcgtt tcttttctgt ggctgcgtga aagccttaaa     1080

gggctccggg agggcccttt gtgcgggggg gagcggctcg gggggtgcgt gcgtgtgtgt     1140

gtgcgtgggg agcgccgcgt gcggcccgcg ctgcccggcg gctgtgagcg ctgcgggcgc     1200

ggcgcggggc tttgtgcgct ccgcgtgtgc gcgaggggag cgcggccggg ggcggtgccc     1260

cgcggtgcgg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg     1320

gtgagcaggg ggtgtgggcg cggcggtcgg gctgtaaccc ccccctgcac ccccctcccc     1380

gagttgctga gcacggcccg gcttcgggtg cggggctccg tgcggggcgt ggcgcggggc     1440

tcgccgtgcc gggcgggggg tggcggcagg tgggggtgcc gggcggggcg gggccgcctc     1500

gggccgggga gggctcgggg gaggggcgcg gcggccccgg agcgccggcg gctgtcgagg     1560

cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc agggacttcc     1620

tttgtcccaa atctggcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg     1680

cgcgggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt     1740

cgccgcgccg ccgtcccctt ctccatctcc agcctcgggg ctgccgcagg gggacggctg     1800

ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag     1860

agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct     1920

ggttattgtg ctgtctcatc attttggcaa agaattctaa tacgactcac tatagggaga     1980

cccaagctgg ctagagccac catggctgga ctgtggctgg gactggtgtg gcagaaactg     2040

ctgctgtggg gggccgcttc cgcactgtca ctggctgggg cttcactggt gctgagcctg     2100

ctgcagaggg tggcctccta cgccagaaag tggcagcaga tgaggcccat ccctaccgtg     2160

gccagagcct atccactggt gggacacgca ctgctgatga agcctgacgg cagagagttc     2220

tttcagcaga tcatcgagta cacagaggag tataggcaca tgccactgct gaagctgtgg     2280

gtgggacccg tgcctatggt ggccctgtac aacgccgaga atgtggaagt gatcctgacc     2340

agcagcaagc agatcgataa gtctagcatg tataagttcc tggagccttg gctgggcctg     2400

ggcctgctga cctctacagg caacaagtgg aggagccgga gaaagatgct gaccccaaca     2460

ttccacttta caatcctgga ggacttcctg gacatcatga acgagcaggc caatatcctg     2520

gtgaagaagc tggagaagca catcaaccag gaggccttta attgcttctt ttacatcacc     2580

ctgtgcgccc tggacatcat ctgtgagaca gctatgggca agaacatcgg cgcccagtct     2640

aatgacgata gcgagtacgt gcgggccgtg tatagaatga gcgagatgat ctttaggcgc     2700

atcaagatgc cctggctgtg gctggatctg tggtatctga tgttcaagga gggctgggag     2760

cacaagaagt ccctgcagat cctgcacacc tttacaaact ctgtgatcgc cgagagagcc     2820

aatgagatga acgccaatga ggactgtagg ggcgatggaa ggggcagcgc cccttccaag     2880

aacaagcgga gagccttcct ggacctgctg ctgagcgtga ccgacgatga gggcaatcgc     2940

ctgtcccacg aggacatccg ggaggaggtg gatacattca tgtttgaggg acacgacacc     3000

acagccgccg ccatcaactg gtccctgtac ctgctgggct ctaatccaga ggtgcagaag     3060

aaggtggatc acgagctgga cgacgtgttc ggcaagtccg acaggccagc aaccgtggag     3120

gatctgaaga agctgagata cctggagtgc gtgatcaagg agacactgcg cctgttcccc     3180

tctgtgcctc tgtttgcccg gtccgtgtct gaggactgtg aggtggccgg ctatcgcgtg     3240

ctgaagggca ccgaggccgt gatcatccct tacgccctgc accgggaccc caggtatttc     3300

cctaacccag aggagtttca gccagagaga ttctttcccg agaatgccca gggcaggcac     3360

ccttacgcct atgtgccatt ctccgccgga ccaaggaact gcatcggaca gaagtttgcc     3420

gtgatggagg agaaaaccat cctgtcttgt atcctgagac acttctggat cgagagcaat     3480

cagaagaggg aggagctggg cctggaggga cagctgatcc tgcggccaag caacggcatc     3540

tggatcaaac tgaaaagaag gaacgctgac gagaggtaaa agcttggtac cgatatcgcg     3600

gccgccctag ggagctcctc gaggcggccc gctcgagtct agagggccct tcgaaggtaa     3660

gcctatccct aaccctctcc tcggtctcga ttctacgcgt accggtcatc atcaccatca     3720

ccattgagtt tcgataatca acctctggat tacaaaattt gtgaaagatt gactggtatt     3780

cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat     3840

gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct     3900

ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct     3960

gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc     4020

gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg     4080

acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc     4140

tttccttggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac     4200

gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg     4260

cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc     4320

ccgcatcgaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     4380

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     4440

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     4500

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     4560

ggtgggctct atggcttctg aggcggaaag aaccagatcc tctcttaagg tagcatcgag     4620

atttaaatta gggataacag ggtaatggcg cgggccgcag gaacccctag tgatggagtt     4680

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     4740

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct gcctgcagg      4799


<210>  61
<211>  4539
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated expression construct

<400>  61
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcctaa ggcaattgag atctcgacat tgattattga      180

ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc      240

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      300

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      360

aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      420

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      480

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      540

ccatgggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      720

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      780

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg ctgcgttgcc      840

ttcgccccgt gccccgctcc gcgccgcctc gcgccgcccg ccccggctct gactgaccgc      900

gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta attagcgctt      960

ggtttaatga cggctcgttt cttttctgtg gctgcgtgaa agccttaaag ggctccggga     1020

gggccctttg tgcggggggg agcggctcgg ggggtgcgtg cgtgtgtgtg tgcgtgggga     1080

gcgccgcgtg cggcccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg gcgcggggct     1140

ttgtgcgctc cgcgtgtgcg cgaggggagc gcggccgggg gcggtgcccc gcggtgcggg     1200

ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg cgtggggggg tgagcagggg     1260

gtgtgggcgc ggcggtcggg ctgtaacccc cccctgcacc cccctccccg agttgctgag     1320

cacggcccgg cttcgggtgc ggggctccgt gcggggcgtg gcgcggggct cgccgtgccg     1380

ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg ggccgcctcg ggccggggag     1440

ggctcggggg aggggcgcgg cggccccgga gcgccggcgg ctgtcgaggc gcggcgagcc     1500

gcagccattg ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa     1560

tctggcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcgggcgaag     1620

cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc     1680

cgtccccttc tccatctcca gcctcggggc tgccgcaggg ggacggctgc cttcgggggg     1740

gacggggcag ggcggggttc ggcttctggc gtgtgaccgg cggctctaga gcctctgcta     1800

accatgttca tgccttcttc tttttcctac agctcctggg caacgtgctg gttattgtgc     1860

tgtctcatca ttttggcaaa gaattctaat acgactcact atagggagac ccaagctggc     1920

tagccaaagc ttccaccatg gcggggctct ggctggggct cgtgtggcag aagctgctgc     1980

tgtggggcgc ggcgagtgcc ctttccctgg ccggcgccag tctggtcctg agcctgctgc     2040

agagggtggc gagctacgcg cggaaatggc agcagatgcg gcccatcccc acggtggccc     2100

gcgcctaccc actggtgggc cacgcgctgc tgatgaagcc ggacgggcga gaattttttc     2160

agcagatcat tgagtacaca gaggaatacc gccacatgcc gctgctgaag ctctgggtcg     2220

ggccagtgcc catggtggcc ctttataatg cagaaaatgt ggaggtaatt ttaactagtt     2280

caaagcaaat tgacaaatcc tctatgtaca agtttttaga accatggctt ggcctaggac     2340

ttcttacaag tactggaaac aaatggcgct ccaggagaaa gatgttaaca cccactttcc     2400

attttaccat tctggaagat ttcttagata tcatgaatga acaagcaaat atattggtta     2460

agaaacttga aaaacacatt aaccaagaag catttaactg ctttttttac atcactcttt     2520

gtgccttaga tatcatctgt gaaacagcta tggggaagaa tattggtgct caaagtaatg     2580

atgattccga gtatgtccgt gcagtttata gaatgagtga gatgatattt cgaagaataa     2640

agatgccctg gctttggctt gatctctggt accttatgtt taaagaagga tgggaacaca     2700

aaaagagcct tcagatccta catactttta ccaacagtgt catcgctgaa cgggccaatg     2760

aaatgaacgc caatgaagac tgtagaggtg atggcagggg ctctgccccc tccaaaaata     2820

aacgcagggc ctttcttgac ttgcttttaa gtgtgactga tgacgaaggg aacaggctaa     2880

gtcatgaaga tattcgagaa gaagttgaca ccttcatgtt tgaggggcac gatacaactg     2940

cagctgcaat aaactggtcc ttatacctgt tgggttctaa cccagaagtc cagaaaaaag     3000

tggatcatga attggatgac gtgtttggga agtctgaccg tcccgctaca gtagaagacc     3060

tgaagaaact tcggtatctg gaatgtgtta ttaaggagac ccttcgcctt tttccttctg     3120

ttcctttatt tgcccgtagt gttagtgaag attgtgaagt ggcaggttac agagttctaa     3180

aaggcactga agccgtcatc attccctatg cattgcacag agatccgaga tacttcccca     3240

accccgagga gttccagcct gagcggttct tccccgagaa tgcacaaggg cgccatccat     3300

atgcctacgt gcccttctct gctggcccca ggaactgtat aggtcaaaag tttgctgtga     3360

tggaagaaaa gaccattctt tcgtgcatcc tgaggcactt ttggatagaa tccaaccaga     3420

aaagagaaga gcttggtcta gaaggacagt tgattcttcg tccaagtaat ggcatctgga     3480

tcaagttgaa gaggagaaat gcagatgaac gctaagcggc cgcaactcga gactctagag     3540

gttaatcgat aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa     3600

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat     3660

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta     3720

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc     3780

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt     3840

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     3900

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc     3960

ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc     4020

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct     4080

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca     4140

tcgaaacccg ctgactagac gactgtgcct tctagttgcc agccatctgt tgtttgcccc     4200

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     4260

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     4320

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     4380

tctatggccg cgggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4440

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     4500

cggcctcagt gagcgagcga gcgcgcagct gcctgcagg                            4539


<210>  62
<211>  4539
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated expression construct

<400>  62
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcctaa ggcaattgag atctcgacat tgattattga      180

ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc      240

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      300

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      360

aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      420

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      480

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      540

ccatgggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      720

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      780

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg ctgcgttgcc      840

ttcgccccgt gccccgctcc gcgccgcctc gcgccgcccg ccccggctct gactgaccgc      900

gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta attagcgctt      960

ggtttaatga cggctcgttt cttttctgtg gctgcgtgaa agccttaaag ggctccggga     1020

gggccctttg tgcggggggg agcggctcgg ggggtgcgtg cgtgtgtgtg tgcgtgggga     1080

gcgccgcgtg cggcccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg gcgcggggct     1140

ttgtgcgctc cgcgtgtgcg cgaggggagc gcggccgggg gcggtgcccc gcggtgcggg     1200

ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg cgtggggggg tgagcagggg     1260

gtgtgggcgc ggcggtcggg ctgtaacccc cccctgcacc cccctccccg agttgctgag     1320

cacggcccgg cttcgggtgc ggggctccgt gcggggcgtg gcgcggggct cgccgtgccg     1380

ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg ggccgcctcg ggccggggag     1440

ggctcggggg aggggcgcgg cggccccgga gcgccggcgg ctgtcgaggc gcggcgagcc     1500

gcagccattg ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa     1560

tctggcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcgggcgaag     1620

cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc     1680

cgtccccttc tccatctcca gcctcggggc tgccgcaggg ggacggctgc cttcgggggg     1740

gacggggcag ggcggggttc ggcttctggc gtgtgaccgg cggctctaga gcctctgcta     1800

accatgttca tgccttcttc tttttcctac agctcctggg caacgtgctg gttattgtgc     1860

tgtctcatca ttttggcaaa gaattctaat acgactcact atagggagac ccaagctggc     1920

tagccaaagc ttccaccatg gcggggctct ggctggggct cgtgtggcag aagctgctgc     1980

tgtggggcgc ggcgagtgcc ctttccctgg ccggcgccag tctggtcctg agcctgctgc     2040

agagggtggc gagctacgcg cggaaatggc agcagatgcg gcccatcccc acggtggccc     2100

gcgcctaccc actggtgggc cacgcgctgc tgatgaagcc ggacgggcga gaattttttc     2160

agcagatcat tgagtacaca gaggaatacc gccacatgcc gctgctgaag ctctgggtcg     2220

ggccagtgcc catggtggcc ctttataatg cagaaaatgt ggaggtaatt ttaactagtt     2280

caaagcaaat tgacaaatcc tctatgtaca agtttttaga accatggctt ggcctaggac     2340

ttcttacaag tactggaaac aaatggcgct ccaggagaaa gatgttaaca cccactttcc     2400

attttaccat tctggaagat ttcttagata tcatgaatga acaagcaaat atattggtta     2460

agaaacttga aaaacacatt aaccaagaag catttaactg ctttttttac atcactcttt     2520

gtgccttaga tatcatctgt gaaacagcta tggggaagaa tattggtgct caaagtaatg     2580

atgattccga gtatgtccgt gcagtttata gaatgagtga gatgatattt cgaagaataa     2640

agatgccctg gctttggctt gatctctggt accttatgtt taaagaagga tgggaacaca     2700

aaaagagcct taagatccta catactttta ccaacagtgt catcgcggaa cgggccaatg     2760

aaatgaacgc caatgaagac tgtagaggtg atggcagggg ctctgccccc tccaaaaata     2820

aacgcagggc ctttcttgac ttgcttttaa gtgtgactga tgacgaaggg aacaggctaa     2880

gtcatgaaga tattcgagaa gaagttgaca ccttcatgtt tgaggggcac gatacaactg     2940

cagctgcaat aaactggtcc ttatacctgt tgggttctaa cccagaagtc cagaaaaaag     3000

tggatcatga attggatgac gtgtttggga agtctgaccg tcccgctaca gtagaagacc     3060

tgaagaaact tcggtatctg gaatgtgtta ttaaggagac ccttcgcctt tttccttctg     3120

ttcctttatt tgcccgtagt gttagtgaag attgtgaagt ggcaggttac agagttctaa     3180

aaggcactga agccgtcatc attccctatg cattgcacag agatccgaga tacttcccca     3240

accccgagga gttccagcct gagcggttct tccccgagaa tgcacaaggg cgccatccat     3300

atgcctacgt gcccttctct gctggcccca ggaactgtat aggtcaaaag tttgctgtga     3360

tggaagaaaa gaccattctt tcgtgcatcc tgaggcactt ttggatagaa tccaaccaga     3420

aaagagaaga gcttggtcta gaaggacagt tgattcttcg tccaagtaat ggcatctgga     3480

tcaagttgaa gaggagaaat gcagatgaac gctaagcggc cgcaactcga gactctagag     3540

gttaatcgat aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa     3600

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat     3660

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta     3720

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc     3780

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt     3840

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     3900

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc     3960

ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc     4020

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct     4080

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca     4140

tcgaaacccg ctgactagac gactgtgcct tctagttgcc agccatctgt tgtttgcccc     4200

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     4260

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     4320

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     4380

tctatggccg cgggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4440

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     4500

cggcctcagt gagcgagcga gcgcgcagct gcctgcagg                            4539


<210>  63
<211>  4539
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated expression construct

<400>  63
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggcctaa ggcaattgag atctcgacat tgattattga      180

ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc      240

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      300

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      360

aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      420

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      480

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      540

ccatgggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      720

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      780

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg ctgcgttgcc      840

ttcgccccgt gccccgctcc gcgccgcctc gcgccgcccg ccccggctct gactgaccgc      900

gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta attagcgctt      960

ggtttaatga cggctcgttt cttttctgtg gctgcgtgaa agccttaaag ggctccggga     1020

gggccctttg tgcggggggg agcggctcgg ggggtgcgtg cgtgtgtgtg tgcgtgggga     1080

gcgccgcgtg cggcccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg gcgcggggct     1140

ttgtgcgctc cgcgtgtgcg cgaggggagc gcggccgggg gcggtgcccc gcggtgcggg     1200

ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg cgtggggggg tgagcagggg     1260

gtgtgggcgc ggcggtcggg ctgtaacccc cccctgcacc cccctccccg agttgctgag     1320

cacggcccgg cttcgggtgc ggggctccgt gcggggcgtg gcgcggggct cgccgtgccg     1380

ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg ggccgcctcg ggccggggag     1440

ggctcggggg aggggcgcgg cggccccgga gcgccggcgg ctgtcgaggc gcggcgagcc     1500

gcagccattg ccttttatgg taatcgtgcg agagggcgca gggacttcct ttgtcccaaa     1560

tctggcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcgggcgaag     1620

cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc     1680

cgtccccttc tccatctcca gcctcggggc tgccgcaggg ggacggctgc cttcgggggg     1740

gacggggcag ggcggggttc ggcttctggc gtgtgaccgg cggctctaga gcctctgcta     1800

accatgttca tgccttcttc tttttcctac agctcctggg caacgtgctg gttattgtgc     1860

tgtctcatca ttttggcaaa gaattctaat acgactcact atagggagac ccaagctggc     1920

tagccaaagc ttccaccatg gctggactgt ggctgggact ggtgtggcag aaactgctgc     1980

tgtggggggc cgcttccgca ctgtcactgg ctggggcttc actggtgctg agcctgctgc     2040

agagggtggc ctcctacgcc agaaagtggc agcagatgag gcccatccct accgtggcca     2100

gagcctatcc actggtggga cacgcactgc tgatgaagcc tgacggcaga gagttctttc     2160

agcagatcat cgagtacaca gaggagtata ggcacatgcc actgctgaag ctgtgggtgg     2220

gacccgtgcc tatggtggcc ctgtacaacg ccgagaatgt ggaagtgatc ctgaccagca     2280

gcaagcagat cgataagtct agcatgtata agttcctgga gccttggctg ggcctgggcc     2340

tgctgacctc tacaggcaac aagtggagga gccggagaaa gatgctgacc ccaacattcc     2400

actttacaat cctggaggac ttcctggaca tcatgaacga gcaggccaat atcctggtga     2460

agaagctgga gaagcacatc aaccaggagg cctttaattg cttcttttac atcaccctgt     2520

gcgccctgga catcatctgt gagacagcta tgggcaagaa catcggcgcc cagtctaatg     2580

acgatagcga gtacgtgcgg gccgtgtata gaatgagcga gatgatcttt aggcgcatca     2640

agatgccctg gctgtggctg gatctgtggt atctgatgtt caaggagggc tgggagcaca     2700

agaagtccct gcagatcctg cacaccttta caaactctgt gatcgccgag agagccaatg     2760

agatgaacgc caatgaggac tgtaggggcg atggaagggg cagcgcccct tccaagaaca     2820

agcggagagc cttcctggac ctgctgctga gcgtgaccga cgatgagggc aatcgcctgt     2880

cccacgagga catccgggag gaggtggata cattcatgtt tgagggacac gacaccacag     2940

ccgccgccat caactggtcc ctgtacctgc tgggctctaa tccagaggtg cagaagaagg     3000

tggatcacga gctggacgac gtgttcggca agtccgacag gccagcaacc gtggaggatc     3060

tgaagaagct gagatacctg gagtgcgtga tcaaggagac actgcgcctg ttcccctctg     3120

tgcctctgtt tgcccggtcc gtgtctgagg actgtgaggt ggccggctat cgcgtgctga     3180

agggcaccga ggccgtgatc atcccttacg ccctgcaccg ggaccccagg tatttcccta     3240

acccagagga gtttcagcca gagagattct ttcccgagaa tgcccagggc aggcaccctt     3300

acgcctatgt gccattctcc gccggaccaa ggaactgcat cggacagaag tttgccgtga     3360

tggaggagaa aaccatcctg tcttgtatcc tgagacactt ctggatcgag agcaatcaga     3420

agagggagga gctgggcctg gagggacagc tgatcctgcg gccaagcaac ggcatctgga     3480

tcaaactgaa aagaaggaac gctgacgaga ggtaagcggc cgcaactcga gactctagag     3540

gttaatcgat aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa     3600

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat     3660

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta     3720

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc     3780

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt     3840

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     3900

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc     3960

ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc     4020

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct     4080

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca     4140

tcgaaacccg ctgactagac gactgtgcct tctagttgcc agccatctgt tgtttgcccc     4200

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     4260

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     4320

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     4380

tctatggccg cgggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4440

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     4500

cggcctcagt gagcgagcga gcgcgcagct gcctgcagg                            4539


<210>  64
<211>  2403
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetically generated expression construct

<400>  64
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggacg      120

cgtaggcctg attggctccg gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc      180

cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt ggcgcggggt      240

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      300

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      360

acaggtgtcg tgacgcgacc aggtatgcat ctgcagctct aaggtaaata taaaattttt      420

aagtgtataa tgtgttaaac tactgattct aattgtttct ctcttttaga ttccaacctt      480

tggaactgac tgcagggatc caagctttct agagccacca tggctggact gtggctggga      540

ctggtgtggc agaaactgct gctgtggggg gccgcttccg cactgtcact ggctggggct      600

tcactggtgc tgagcctgct gcagagggtg gcctcctacg ccagaaagtg gcagcagatg      660

aggcccatcc ctaccgtggc cagagcctat ccactggtgg gacacgcact gctgatgaag      720

cctgacggca gagagttctt tcagcagatc atcgagtaca cagaggagta taggcacatg      780

ccactgctga agctgtgggt gggacccgtg cctatggtgg ccctgtacaa cgccgagaat      840

gtggaagtga tcctgaccag cagcaagcag atcgataagt ctagcatgta taagttcctg      900

gagccttggc tgggcctggg cctgctgacc tctacaggca acaagtggag gagccggaga      960

aagatgctga ccccaacatt ccactttaca atcctggagg acttcctgga catcatgaac     1020

gagcaggcca atatcctggt gaagaagctg gagaagcaca tcaaccagga ggcctttaat     1080

tgcttctttt acatcaccct gtgcgccctg gacatcatct gtgagacagc tatgggcaag     1140

aacatcggcg cccagtctaa tgacgatagc gagtacgtgc gggccgtgta tagaatgagc     1200

gagatgatct ttaggcgcat caagatgccc tggctgtggc tggatctgtg gtatctgatg     1260

ttcaaggagg gctgggagca caagaagtcc ctgcagatcc tgcacacctt tacaaactct     1320

gtgatcgccg agagagccaa tgagatgaac gccaatgagg actgtagggg cgatggaagg     1380

ggcagcgccc cttccaagaa caagcggaga gccttcctgg acctgctgct gagcgtgacc     1440

gacgatgagg gcaatcgcct gtcccacgag gacatccggg aggaggtgga tacattcatg     1500

tttgagggac acgacaccac agccgccgcc atcaactggt ccctgtacct gctgggctct     1560

aatccagagg tgcagaagaa ggtggatcac gagctggacg acgtgttcgg caagtccgac     1620

aggccagcaa ccgtggagga tctgaagaag ctgagatacc tggagtgcgt gatcaaggag     1680

acactgcgcc tgttcccctc tgtgcctctg tttgcccggt ccgtgtctga ggactgtgag     1740

gtggccggct atcgcgtgct gaagggcacc gaggccgtga tcatccctta cgccctgcac     1800

cgggacccca ggtatttccc taacccagag gagtttcagc cagagagatt ctttcccgag     1860

aatgcccagg gcaggcaccc ttacgcctat gtgccattct ccgccggacc aaggaactgc     1920

atcggacaga agtttgccgt gatggaggag aaaaccatcc tgtcttgtat cctgagacac     1980

ttctggatcg agagcaatca gaagagggag gagctgggcc tggagggaca gctgatcctg     2040

cggccaagca acggcatctg gatcaaactg aaaagaagga acgctgacga gaggtaaaag     2100

cttgaattcc tcgaggatcc aataaaagat ctttattttc attagatctg tgtgttggtt     2160

ttttgtgtgt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     2220

ctggaaggtg ccactcccag tttaaactta attaagggcc gcaggaaccc ctagtgatgg     2280

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     2340

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc     2400

agg                                                                   2403


